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Poster Presentations - Proffered Abstracts最新文献

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Abstract P133: NF-κB and NRF2 pathways dysregulation is associated with improved outcomes in HPV-associated head and neck cancer P133: NF-κB和NRF2通路失调与hpv相关头颈癌预后改善相关
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p133
Aditi Kothari, T. Schrank, W. Yarbrough, N. Isaeva
{"title":"Abstract P133: NF-κB and NRF2 pathways dysregulation is associated with improved outcomes in HPV-associated head and neck cancer","authors":"Aditi Kothari, T. Schrank, W. Yarbrough, N. Isaeva","doi":"10.1158/1535-7163.targ-21-p133","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p133","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84795394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P238: Derazantinib, an inhibitor of fibroblast growth factor receptors 1-3, synergises with paclitaxel in pre-clinical gastric tumor models P238:成纤维细胞生长因子受体1-3抑制剂Derazantinib在临床前胃肿瘤模型中与紫杉醇协同作用
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p238
P. Mcsheehy, M. El Shemerly, F. Bachmann, L. Kellenberger, H. Lane
{"title":"Abstract P238: Derazantinib, an inhibitor of fibroblast growth factor receptors 1-3, synergises with paclitaxel in pre-clinical gastric tumor models","authors":"P. Mcsheehy, M. El Shemerly, F. Bachmann, L. Kellenberger, H. Lane","doi":"10.1158/1535-7163.targ-21-p238","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p238","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78207880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P103: The introduction of a single strain of Bacillus into a germ-free environment did not impact the anti-PD-1 efficacy in a MC38 syngeneic model 摘要P103:在MC38同源模型中，将一株芽孢杆菌引入无菌环境对其抗pd -1的作用没有影响
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p103
Tao Yang, B. Chen, Rongfei Lu, X. An, M. Zang, Jingjun Li, Sheng Guo, W. Qian, J. Fei, Tongyang Hao, Edward Xu, H. Li
{"title":"Abstract P103: The introduction of a single strain of Bacillus into a germ-free environment did not impact the anti-PD-1 efficacy in a MC38 syngeneic model","authors":"Tao Yang, B. Chen, Rongfei Lu, X. An, M. Zang, Jingjun Li, Sheng Guo, W. Qian, J. Fei, Tongyang Hao, Edward Xu, H. Li","doi":"10.1158/1535-7163.targ-21-p103","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p103","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78215275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P104: Therapeutic targeting of TREM1 with PY159 promotes myeloid cell reprogramming and unleashes anti-tumor immunity P104: PY159靶向tre1治疗可促进髓细胞重编程，释放抗肿瘤免疫
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p104
E. Mayes, V. Juric, M. Binnewies, P. Canaday, Tian Lee, S. Dash, Joshua L. Pollack, J. Rudolph, V. Huang, X. Du, N. Jahchan, Asa J. Ramoth, S. Mankikar, M. Norng, C. Santamaria, K. Baker, L. Liang
{"title":"Abstract P104: Therapeutic targeting of TREM1 with PY159 promotes myeloid cell reprogramming and unleashes anti-tumor immunity","authors":"E. Mayes, V. Juric, M. Binnewies, P. Canaday, Tian Lee, S. Dash, Joshua L. Pollack, J. Rudolph, V. Huang, X. Du, N. Jahchan, Asa J. Ramoth, S. Mankikar, M. Norng, C. Santamaria, K. Baker, L. Liang","doi":"10.1158/1535-7163.targ-21-p104","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p104","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75962343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract P237: PRT2527 is a potent and selective CDK9 inhibitor that demonstrates anti-cancer activity in preclinical models of hematological malignancies and solid tumors with MYC amplification P237: PRT2527是一种有效的选择性CDK9抑制剂，在血液恶性肿瘤和MYC扩增实体瘤的临床前模型中显示出抗癌活性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p237
Yang W. Zhang, Liang Lu, Min Wang, D. Rominger, S. Ruepp, Kirsten Gallagher, W. Gowen-MacDonald, C. Dai, M. Cowart, A. Combs, Bruce R Ruggeri, P. Scherle, K. Vaddi
{"title":"Abstract P237: PRT2527 is a potent and selective CDK9 inhibitor that demonstrates anti-cancer activity in preclinical models of hematological malignancies and solid tumors with MYC amplification","authors":"Yang W. Zhang, Liang Lu, Min Wang, D. Rominger, S. Ruepp, Kirsten Gallagher, W. Gowen-MacDonald, C. Dai, M. Cowart, A. Combs, Bruce R Ruggeri, P. Scherle, K. Vaddi","doi":"10.1158/1535-7163.targ-21-p237","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p237","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"540 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75755764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract P048: A phase 2 study of VS-6766 (dual RAF/MEK inhibitor) RAMP 202, as a single agent and in combination with defactinib (FAK inhibitor) in recurrent KRAS-mutant (KRAS-MT) non-small cell lung cancer (NSCLC) P048: VS-6766(双RAF/MEK抑制剂)RAMP 202作为单药和与defactinib (FAK抑制剂)联合治疗复发性KRAS-MT非小细胞肺癌(NSCLC)的2期研究
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p048
D. Camidge, J. Pachter, A. Koustenis, Gloria Patrick, D. Spigel
{"title":"Abstract P048: A phase 2 study of VS-6766 (dual RAF/MEK inhibitor) RAMP 202, as a single agent and in combination with defactinib (FAK inhibitor) in recurrent KRAS-mutant (KRAS-MT) non-small cell lung cancer (NSCLC)","authors":"D. Camidge, J. Pachter, A. Koustenis, Gloria Patrick, D. Spigel","doi":"10.1158/1535-7163.targ-21-p048","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p048","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72977076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P004: Orthotopic patient-derived xenografts are effective precision oncology models in predicting therapeutic response and acquired drug resistance 摘要P004:原位患者来源的异种移植物是预测治疗反应和获得性耐药的有效精确肿瘤模型
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p004
J. Nakashima, Jantzen Sperry
{"title":"Abstract P004: Orthotopic patient-derived xenografts are effective precision oncology models in predicting therapeutic response and acquired drug resistance","authors":"J. Nakashima, Jantzen Sperry","doi":"10.1158/1535-7163.targ-21-p004","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p004","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73248811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P177: NPEPPS regulates cisplatin-resistance and can be targeted to overcome treatment resistance in patient-derived bladder cancer tumoroids 摘要P177: NPEPPS调节顺铂耐药，可靶向克服患者源性膀胱癌类肿瘤的治疗耐药
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p177
M. Scholtes, M. Akbarzadeh, D. Theodorescu, J. Costello, T. Mahmoudi, T. Zuiverloon
{"title":"Abstract P177: NPEPPS regulates cisplatin-resistance and can be targeted to overcome treatment resistance in patient-derived bladder cancer tumoroids","authors":"M. Scholtes, M. Akbarzadeh, D. Theodorescu, J. Costello, T. Mahmoudi, T. Zuiverloon","doi":"10.1158/1535-7163.targ-21-p177","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p177","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74488508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P030: Chemoprevention by the mutant p53 reactivator SLMP53-2 on ultraviolet radiation-induced skin cancer P030:突变型p53再激活物SLMP53-2对紫外线诱发皮肤癌的化学预防作用
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p030
Joana B Loureiro, R. Ribeiro, N. Nazareth, Tiago Ferreira, Adelina Quaresma, Valentina Barcherini, L. Marabini, P. A. Oliveira, Maria M. M. Santos, L. Saraíva
{"title":"Abstract P030: Chemoprevention by the mutant p53 reactivator SLMP53-2 on ultraviolet radiation-induced skin cancer","authors":"Joana B Loureiro, R. Ribeiro, N. Nazareth, Tiago Ferreira, Adelina Quaresma, Valentina Barcherini, L. Marabini, P. A. Oliveira, Maria M. M. Santos, L. Saraíva","doi":"10.1158/1535-7163.targ-21-p030","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p030","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73715622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P001: The anti-angiogenic antibody BD0801 demonstrates better anti-tumor activity than bevacizumab and synergize with chemotherapies in multiple tumor models 摘要P001:抗血管生成抗体BD0801在多种肿瘤模型中表现出比贝伐单抗更好的抗肿瘤活性，并与化疗药物协同作用
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p001
Liting Xue, Jia-ming Tang, Yuyin Ding, Lei Song, Shansen Xu, Yue Huang, Yan Wu, W. Song, R. Tang, Wen-qing Yang
{"title":"Abstract P001: The anti-angiogenic antibody BD0801 demonstrates better anti-tumor activity than bevacizumab and synergize with chemotherapies in multiple tumor models","authors":"Liting Xue, Jia-ming Tang, Yuyin Ding, Lei Song, Shansen Xu, Yue Huang, Yan Wu, W. Song, R. Tang, Wen-qing Yang","doi":"10.1158/1535-7163.targ-21-p001","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p001","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73807997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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