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Poster Presentations - Proffered Abstracts最新文献

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Abstract P210: MDM2 gene amplification as a predictive biomarker for the MDM2 inhibitor milademetan P210: MDM2基因扩增作为MDM2抑制剂米拉德美坦的预测性生物标志物
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p210
V. Tirunagaru, M. Gounder, Prasanna Kumar, D. Hong, R. Doebele
{"title":"Abstract P210: MDM2 gene amplification as a predictive biomarker for the MDM2 inhibitor milademetan","authors":"V. Tirunagaru, M. Gounder, Prasanna Kumar, D. Hong, R. Doebele","doi":"10.1158/1535-7163.targ-21-p210","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p210","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74573215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P241: A highly potent HPK1 inhibitor augments immune cell activation and anti-tumor immunity in a syngeneic tumor mouse model P241:一种高效的HPK1抑制剂在同基因肿瘤小鼠模型中增强免疫细胞激活和抗肿瘤免疫
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p241
Hao Liu, Lei Wu, Song Feng, Wei Huang, Huijuan Li, Jing Lin, Yangyang Liu, L. Mei, B. Ren, Julie Xie, L. Yao, W. Zhong
{"title":"Abstract P241: A highly potent HPK1 inhibitor augments immune cell activation and anti-tumor immunity in a syngeneic tumor mouse model","authors":"Hao Liu, Lei Wu, Song Feng, Wei Huang, Huijuan Li, Jing Lin, Yangyang Liu, L. Mei, B. Ren, Julie Xie, L. Yao, W. Zhong","doi":"10.1158/1535-7163.targ-21-p241","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p241","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89424444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P139: An estrogen receptor beta agonist liquiritigenin potentiates inhibition of hormone-dependent breast-cancer growth by cholesterol biosynthesis inhibitor RO 48-8071 摘要:雌激素受体激动剂利尿原素增强了胆固醇生物合成抑制剂RO 48-8071对激素依赖性乳腺癌生长的抑制作用
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p139
Yayun Liang, S. Hyder
{"title":"Abstract P139: An estrogen receptor beta agonist liquiritigenin potentiates inhibition of hormone-dependent breast-cancer growth by cholesterol biosynthesis inhibitor RO 48-8071","authors":"Yayun Liang, S. Hyder","doi":"10.1158/1535-7163.targ-21-p139","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p139","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87364634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P121: Dual RAF/MEK inhibitor VS-6766 for treatment of solid tumors with diverse MAPK pathway alterations P121:双RAF/MEK抑制剂VS-6766治疗多种MAPK通路改变的实体肿瘤
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p121
S. Coma, S. Chowdhury, M. Musteanu, M. Barbacid, J. Pachter
{"title":"Abstract P121: Dual RAF/MEK inhibitor VS-6766 for treatment of solid tumors with diverse MAPK pathway alterations","authors":"S. Coma, S. Chowdhury, M. Musteanu, M. Barbacid, J. Pachter","doi":"10.1158/1535-7163.targ-21-p121","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p121","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90235739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P083: Metastatic NSCLC -Re-challenging with first generation TKI after a drug free holiday after resistance to 3rd generation TKI P083:转移性NSCLC -在对第三代TKI耐药后无药期后再次挑战第一代TKI
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p083
Surya Acharya
{"title":"Abstract P083: Metastatic NSCLC -Re-challenging with first generation TKI after a drug free holiday after resistance to 3rd generation TKI","authors":"Surya Acharya","doi":"10.1158/1535-7163.targ-21-p083","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p083","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82290387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P190: Safety and efficacy of neoadjuvant intravesical oncolytic MV-NIS in patients with urothelial carcinoma P190:新辅助膀胱内溶瘤MV-NIS治疗尿路上皮癌的安全性和有效性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p190
T. Miest, B. Leibovich, S. Bardot, P. Young, S. Boorjian, M. Gonzalgo, L. Herrera-Hernandez, M. Tollefson, J. Karnes, Paige E Nichols, Tessa Kroeninger, R. Graham, C. Lahana, M. Reckner, Alysha N. Newsom, N. Packiriswamy, Janice Anoka, K. Peng, E. Wiegert, A. Bexon, Shruthi Naik
{"title":"Abstract P190: Safety and efficacy of neoadjuvant intravesical oncolytic MV-NIS in patients with urothelial carcinoma","authors":"T. Miest, B. Leibovich, S. Bardot, P. Young, S. Boorjian, M. Gonzalgo, L. Herrera-Hernandez, M. Tollefson, J. Karnes, Paige E Nichols, Tessa Kroeninger, R. Graham, C. Lahana, M. Reckner, Alysha N. Newsom, N. Packiriswamy, Janice Anoka, K. Peng, E. Wiegert, A. Bexon, Shruthi Naik","doi":"10.1158/1535-7163.targ-21-p190","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p190","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86132738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P095: Isogenic CRISPR anchor screens identified actionable nodes to CHK1/2 inhibitor prexasertib in TP53 mutant cancer P095:等基因CRISPR锚定筛选在TP53突变型癌症中鉴定出CHK1/2抑制剂prexasertib的可操作节点
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p095
T. Teng, Stephen Paik, Shan-Chuan Zhao, Ashley H Choi, S. Lombardo, Shangtao Liu, Samuel R Meier, Yi Yu, Jannik N. Anderson, A. Huang, Fang Li, Xuewen Pan
{"title":"Abstract P095: Isogenic CRISPR anchor screens identified actionable nodes to CHK1/2 inhibitor prexasertib in TP53 mutant cancer","authors":"T. Teng, Stephen Paik, Shan-Chuan Zhao, Ashley H Choi, S. Lombardo, Shangtao Liu, Samuel R Meier, Yi Yu, Jannik N. Anderson, A. Huang, Fang Li, Xuewen Pan","doi":"10.1158/1535-7163.targ-21-p095","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p095","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78586176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P186: Preclinical evaluation of the proteasome inhibitor ixazomib (MLN2238) on nasopharyngeal cacinoma (NPC) P186:蛋白酶体抑制剂ixazomib (MLN2238)治疗鼻咽癌(NPC)的临床前评价
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p186
K. Li, V. Lee, G. Tsao
{"title":"Abstract P186: Preclinical evaluation of the proteasome inhibitor ixazomib (MLN2238) on nasopharyngeal cacinoma (NPC)","authors":"K. Li, V. Lee, G. Tsao","doi":"10.1158/1535-7163.targ-21-p186","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p186","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85470167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P176: Discovery and development of novel covalent inhibitors of the YAP-TEAD transcription activity P176: YAP-TEAD转录活性的新型共价抑制剂的发现和开发
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p176
Shi Guo, Cindy Huang, C. Begley, Michael J. Bishop, Ping Cao
{"title":"Abstract P176: Discovery and development of novel covalent inhibitors of the YAP-TEAD transcription activity","authors":"Shi Guo, Cindy Huang, C. Begley, Michael J. Bishop, Ping Cao","doi":"10.1158/1535-7163.targ-21-p176","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p176","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83275758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P098: A chemoproteomic platform for identifying small-molecule modulators of protein-protein interactions, discovering new cancer targets, and revealing previously unknown targets for well-known drugs P098:一个化学蛋白质组学平台，用于鉴定蛋白质相互作用的小分子调节剂，发现新的癌症靶点，揭示已知药物的未知靶点
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p098
Cindy Huang, Vivian Zhang, Ning Deng, Irene Yuan, L. Pullan, C. Begley, P. Cao
{"title":"Abstract P098: A chemoproteomic platform for identifying small-molecule modulators of protein-protein interactions, discovering new cancer targets, and revealing previously unknown targets for well-known drugs","authors":"Cindy Huang, Vivian Zhang, Ning Deng, Irene Yuan, L. Pullan, C. Begley, P. Cao","doi":"10.1158/1535-7163.targ-21-p098","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p098","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88686027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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