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Poster Presentations - Proffered Abstracts最新文献

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Abstract P176: Discovery and development of novel covalent inhibitors of the YAP-TEAD transcription activity P176: YAP-TEAD转录活性的新型共价抑制剂的发现和开发
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p176
Shi Guo, Cindy Huang, C. Begley, Michael J. Bishop, Ping Cao
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引用次数: 0
Abstract P127: Mitochondrial matrix protease ClpP agonists suppress breast cancer stem cell function by downregulating multiple stem cell regulatory mechanisms P127:线粒体基质蛋白酶ClpP激动剂通过下调多种干细胞调控机制抑制乳腺癌干细胞功能
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p127
Y. Greer, L. Hernandez, D. Voeller, R. Chari, Binwu Tang, C. Annunziata, Samuel F Gilbert, L. Wakefield, E. Iwanowicz, L. Graves, S. Lipkowitz
{"title":"Abstract P127: Mitochondrial matrix protease ClpP agonists suppress breast cancer stem cell function by downregulating multiple stem cell regulatory mechanisms","authors":"Y. Greer, L. Hernandez, D. Voeller, R. Chari, Binwu Tang, C. Annunziata, Samuel F Gilbert, L. Wakefield, E. Iwanowicz, L. Graves, S. Lipkowitz","doi":"10.1158/1535-7163.targ-21-p127","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p127","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76793741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P226: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF mutation positive solid tumors P226:一项首次人体(FIH) 1/1b期研究的设计和基本原理，该研究评估了KIN-2787(一种强效、高选择性的泛raf抑制剂)在BRAF突变阳性实体瘤成年患者中的作用
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p226
M. McKean, S. Kato, A. Spira, Yan Xing, Hao Xie, E. Buchbinder, Ken Kobayashi, Richard Williams
{"title":"Abstract P226: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF mutation positive solid tumors","authors":"M. McKean, S. Kato, A. Spira, Yan Xing, Hao Xie, E. Buchbinder, Ken Kobayashi, Richard Williams","doi":"10.1158/1535-7163.targ-21-p226","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p226","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"90 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85930037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P209: Collaborative crosstalk between two apoptosis pathways drives synergy of dual inhibition of BCL-2/MDM2 in preclinical models of neuroblastoma 摘要P209:在神经母细胞瘤临床前模型中，两种凋亡途径之间的协同串扰驱动BCL-2/MDM2双重抑制的协同作用
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p209
Douglas D Fang, Q. Tang, Qixin Wang, Y. Kong, Na Li, F. Zhou, R. Tao, Dajun Yang, Y. Zhai
{"title":"Abstract P209: Collaborative crosstalk between two apoptosis pathways drives synergy of dual inhibition of BCL-2/MDM2 in preclinical models of neuroblastoma","authors":"Douglas D Fang, Q. Tang, Qixin Wang, Y. Kong, Na Li, F. Zhou, R. Tao, Dajun Yang, Y. Zhai","doi":"10.1158/1535-7163.targ-21-p209","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p209","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88692060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P230: A phase 1/2 study of BLU-945, a highly potent and selective inhibitor of epidermal growth factor receptor (EGFR) resistance mutations, in patients with EGFR-mutant non-small cell lung cancer (NSCLC) P230:一项针对表皮生长因子受体(EGFR)耐药突变的高效选择性抑制剂BLU-945在EGFR突变的非小细胞肺癌(NSCLC)患者中的1/2期研究
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p230
D. Spigel, K. Goto, D. Camidge, Y. Elamin, A. D. de Langen, N. Leighl, A. Minchom, Z. Piotrowska, D. Planchard, K. Reckamp, F. Albayya, Jennifer Green, Sean H. J. Kim, M. Louie-Gao, R. Sawtell, A. Zalutskaya, Byoung Chul Co
{"title":"Abstract P230: A phase 1/2 study of BLU-945, a highly potent and selective inhibitor of epidermal growth factor receptor (EGFR) resistance mutations, in patients with EGFR-mutant non-small cell lung cancer (NSCLC)","authors":"D. Spigel, K. Goto, D. Camidge, Y. Elamin, A. D. de Langen, N. Leighl, A. Minchom, Z. Piotrowska, D. Planchard, K. Reckamp, F. Albayya, Jennifer Green, Sean H. J. Kim, M. Louie-Gao, R. Sawtell, A. Zalutskaya, Byoung Chul Co","doi":"10.1158/1535-7163.targ-21-p230","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p230","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85232415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Abstract P045: LUMINOS-103: A basket trial evaluating the safety and efficacy of PVSRIPO and PVSRIPO in combination with anti-PD-1/L1 checkpoint inhibitors in patients with advanced solid tumors 摘要:LUMINOS-103:一项评估PVSRIPO和PVSRIPO联合抗pd -1/L1检查点抑制剂治疗晚期实体瘤患者安全性和有效性的篮子试验
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p045
B. Inman, M. Milowsky, R. Pruthi, M. Posner, Melissa J. Polasek, S. Morris, L. Mixson, K. Orr, Elizabeth M. H. Woodson, A. Kelly, W. Nichols, A. Balar
{"title":"Abstract P045: LUMINOS-103: A basket trial evaluating the safety and efficacy of PVSRIPO and PVSRIPO in combination with anti-PD-1/L1 checkpoint inhibitors in patients with advanced solid tumors","authors":"B. Inman, M. Milowsky, R. Pruthi, M. Posner, Melissa J. Polasek, S. Morris, L. Mixson, K. Orr, Elizabeth M. H. Woodson, A. Kelly, W. Nichols, A. Balar","doi":"10.1158/1535-7163.targ-21-p045","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p045","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87373838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P233: TAS0953/HM06 is effective in preclinical models of diverse tumor types driven by RET alterations P233: TAS0953/HM06在RET改变驱动的多种肿瘤类型的临床前模型中有效
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p233
I. Odintsov, R. Kurth, Kota Ishizawa, L. Delasos, A. Lui, I. Khodos, Connor J. Hagen, Q. Chang, M. Mattar, M. Vojnic, S. Kunte, A. Bonifacio, C. Giuliano, E. de Stanchina, Emily Cheng, E. Lovati, M. Ladanyi, R. Somwar
{"title":"Abstract P233: TAS0953/HM06 is effective in preclinical models of diverse tumor types driven by RET alterations","authors":"I. Odintsov, R. Kurth, Kota Ishizawa, L. Delasos, A. Lui, I. Khodos, Connor J. Hagen, Q. Chang, M. Mattar, M. Vojnic, S. Kunte, A. Bonifacio, C. Giuliano, E. de Stanchina, Emily Cheng, E. Lovati, M. Ladanyi, R. Somwar","doi":"10.1158/1535-7163.targ-21-p233","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p233","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82727489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Abstract P115: Novel patient avatar platform for oncology drug testing using 3D ex vivo models derived from fresh patient tumor tissues P115:利用新鲜患者肿瘤组织的3D离体模型进行肿瘤药物测试的新型患者化身平台
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p115
N. Beztsinna, F. Grillet, Niels Meesters, D. van der Meer, L. Daszkiewicz, K. Yan, E. Spanjaard, W. Vader, L. Price
{"title":"Abstract P115: Novel patient avatar platform for oncology drug testing using 3D ex vivo models derived from fresh patient tumor tissues","authors":"N. Beztsinna, F. Grillet, Niels Meesters, D. van der Meer, L. Daszkiewicz, K. Yan, E. Spanjaard, W. Vader, L. Price","doi":"10.1158/1535-7163.targ-21-p115","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p115","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87798536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P033: CC-95775, a reversible, oral bromodomain and extra-terminal (BET) inhibitor in patients with advanced solid tumors (STs): Results of a phase 1 study P033: CC-95775，一种用于晚期实体瘤(STs)患者的可逆口服溴域和外端(BET)抑制剂:1期研究结果
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p033
T. Lesimple, M. D. de Miguel, Cristophe Le Tourneau, M. Ponz-Sarvisé, M. Sablin, D. Benito, B. Hanna, Henry Chang, Xin Wei, Marta Ocejo Garcia, P. Lardelli, Tania Sánchez, J. Palau, Z. Nikolova, E. Calvo
{"title":"Abstract P033: CC-95775, a reversible, oral bromodomain and extra-terminal (BET) inhibitor in patients with advanced solid tumors (STs): Results of a phase 1 study","authors":"T. Lesimple, M. D. de Miguel, Cristophe Le Tourneau, M. Ponz-Sarvisé, M. Sablin, D. Benito, B. Hanna, Henry Chang, Xin Wei, Marta Ocejo Garcia, P. Lardelli, Tania Sánchez, J. Palau, Z. Nikolova, E. Calvo","doi":"10.1158/1535-7163.targ-21-p033","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p033","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"23 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91447518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P021: Genomic biomarkers for response to 9-ING-41, a small molecule selective glycogen synthase kinase-3 (GSK-3) inhibitor, in pancreas cancer: Preliminary results P021: 9-ING-41(一种小分子选择性糖原合成酶激酶3 (GSK-3)抑制剂)在胰腺癌中应答的基因组生物标志物:初步结果
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p021
Brittany A. Borden, A. D. De Souza, D. Mahalingam, S. Powell, P. Munster, K. Huntington, A. Mazar, Ludmila Calvacante, F. Giles, W. El-Deiry, H. Safran, B. Carneiro
{"title":"Abstract P021: Genomic biomarkers for response to 9-ING-41, a small molecule selective glycogen synthase kinase-3 (GSK-3) inhibitor, in pancreas cancer: Preliminary results","authors":"Brittany A. Borden, A. D. De Souza, D. Mahalingam, S. Powell, P. Munster, K. Huntington, A. Mazar, Ludmila Calvacante, F. Giles, W. El-Deiry, H. Safran, B. Carneiro","doi":"10.1158/1535-7163.targ-21-p021","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p021","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90953355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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