Milton To, P. Yeung, Michael Fox, M. Hammond, F. Cattaruzza, A. Nazeer, C. Koski, Lucas Y Liu, S. Khorsand, Deena A Rennerfeldt, K. Morrissey, Z. Lange, M. Dong, Sharon Lam, M. Derynck, B. Irving, V. Schellenberger
{"title":"摘要:AMX-818是一种新的前药HER2-XPAT T细胞接触剂(TCE),具有有效的T细胞激活,蛋白水解裂解和在异种移植肿瘤中的有效性,并且在NHP(非人灵长类动物)中具有广泛的安全边际。","authors":"Milton To, P. Yeung, Michael Fox, M. Hammond, F. Cattaruzza, A. Nazeer, C. Koski, Lucas Y Liu, S. Khorsand, Deena A Rennerfeldt, K. Morrissey, Z. Lange, M. Dong, Sharon Lam, M. Derynck, B. Irving, V. Schellenberger","doi":"10.1158/1535-7163.targ-21-p193","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"45 1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Abstract P193: AMX-818, a novel prodrug HER2-XPAT T-cell engager (TCE) with potent T cell activation, proteolytic cleavage and efficacy in xenograft tumors, and wide safety margins in NHP (Non Human Primate)\",\"authors\":\"Milton To, P. Yeung, Michael Fox, M. Hammond, F. Cattaruzza, A. Nazeer, C. Koski, Lucas Y Liu, S. Khorsand, Deena A Rennerfeldt, K. Morrissey, Z. Lange, M. Dong, Sharon Lam, M. Derynck, B. Irving, V. Schellenberger\",\"doi\":\"10.1158/1535-7163.targ-21-p193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":20348,\"journal\":{\"name\":\"Poster Presentations - Proffered Abstracts\",\"volume\":\"45 1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Poster Presentations - Proffered Abstracts\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/1535-7163.targ-21-p193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Poster Presentations - Proffered Abstracts","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/1535-7163.targ-21-p193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Abstract P193: AMX-818, a novel prodrug HER2-XPAT T-cell engager (TCE) with potent T cell activation, proteolytic cleavage and efficacy in xenograft tumors, and wide safety margins in NHP (Non Human Primate)