Physiological research最新文献

{"title":"Treadmill Exercise in Rats Attenuates Chronic Unpredictable Stress-Induced Depressive-like Behavior Associated with Melatonin-SIRT1/Nrf2 Signaling in the Prefrontal Cortex.","authors":"Ji-Ping He, Xiao-Yun Su, Jie Men, Jian-Mei Cui, Li-Na Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To explore the ameliorating effect of treadmill exercise on depression-like behavior in rats with chronic unpredictable stress (CUS). Thirty-six Sprague-Dawley rats were divided into three groups (n=12 per group): a control group, a CUS group and a CUS+exercise (CUS+EX) group. The CUS and CUS+EX groups received a 4-week CUS treatment, and the CUS+EX group began a 4-week moderate-intensity treadmill exercise at the second week of CUS treatment. Following the CUS treatment and treadmill exercise, the depressive-like behavior of rats was assessed using the open field test (OFT) and tail suspension test (TST). Plasma melatonin levels were measured using an enzyme-linked immunosorbent assay, and the superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in the prefrontal cortex (PFC) were detected using commercial kits. Compared with the control group, the CUS group showed shortened latency to first immobility and prolonged total immobility time in the TST, and decreased time spent in the center and reduced crossing and vertical activities in the OFT. Additionally, the SOD activity and the protein expressions of sirtuin 1 (SIRT1) and nuclear factor E2 associated factor 2 (Nrf2) in the PFC decreased, whereas the MDA level increased in the CUS group. Four weeks of concurrent treadmill exercise attenuated the effects of CUS: compared with the CUS group, the CUS+EX group exhibited reduced depressive-like behaviors, prevention of the CUS-induced decline in PFC SOD activity and SIRT1/Nrf2 protein expression and attenuation of the CUS-induced increase in PFC MDA levels. Treadmill exercise concurrently increased plasma melatonin levels and activated the SIRT1/Nrf2 antioxidant pathway in the PFC, which may contribute to the observed improvement in depressive-like behavior.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 4","pages":"803-812"},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Tissue Response to Pulsed-Field Ablation for Atrial Fibrillation: Insights from Biomarker Kinetics.","authors":"Karol Zdravecký, Jaroslav Zembjak, Jan Farkaš, Silvia Mišíková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pulsed-field ablation (PFA) has become an important non-thermal modality for pulmonary vein isolation in atrial fibrillation (AF), characterized by myocardial selectivity and reduced collateral tissue injury. However, the physiological biomarker response to PFA remains incompletely defined. This study assessed serial changes in myocardial (troponin T, creatine kinase - CK and its isoenzyme - CK-MB) and renal (urea, creatinine) biomarkers in patients undergoing PFA at a single center and compared these findings with current clinical evidence. The study cohort consisted of 52 patients undergoing PFA (73 % men, 27 % women), with 52 % presenting paroxysmal AF and 48 % persistent AF. The mean left atrial diameter was 45 ± 7 mm and the average left ventricular ejection fraction was 55 ± 7 % The mean ablation burden was 67 ± 23 applications per procedure. Biomarkers were measured before and after ablation. Repeated-measures ANOVA demonstrated significant time effects for all myocardial biomarkers (p < 0.001) and significant interactions with ablation burden. Troponin-T increased from near-zero baseline values to markedly elevated levels immediately and 24-hours after the procedure, while CK and CK-MB rose several-fold with only partial decline after the procedure. In contrast, urea and creatinine remained stable, indicating preserved renal function without acute kidney injury. The number of PFA applications correlated positively with late CK and CK-MB values, suggesting that myocardial biomarker load scales with procedural intensity. These findings align with current literature showing extensive myocardial biorelease after PFA but favorable extracardiac safety. By concurrently analyzing myocardial and renal markers, this study demonstrates that substantial biochemical myocardial injury induced by PFA does not translate into measurable renal dysfunction. Overall, PFA appears physiologically consistent with a profile of robust but targeted myocardial injury and preserved renal safety.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 4","pages":"667-677"},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripubertal Exposure to Silver Nanoparticles (AgNPs) Triggers Follicle Activation, Probably Leading to \"Burnout\" by Stimulating the PI3K/AKT/mTOR/AMPK Signaling Pathway.","authors":"Saber Nehdi, Waleed Aldahmash, Abeer Alhazmi, Anouar Feriani, Maroua Jalouli, Awadh Alhelaisi, Jilani Purusottapatnam Shaik, Saleh Alwasel, Abdel Halim Harrath","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite the widespread use of silver nanoparticles (AgNPs) in consumer, industrial, and biomedical products, their potential effects on female reproductive health, particularly during critical developmental periods, remain insufficiently understood. The present study was therefore designed to investigate in vivo the dose-dependent effects of AgNP exposure on ovarian function and reproductive health in pubertal female rats. Pubertal Wistar albino female rats were divided into control and two AgNP groups (0.05 and 0.50 mg/kg/day). After one month of therapy, the females in the different groups were euthanized, and ovarian samples were collected. The results indicated that administration of AgNPs significantly increases the number of primordial follicles and significantly increases the number of growing follicles. Western blot analysis revealed that aromatase (Cyp19) and proliferating cell nuclear antigen (PCNA) were upregulated in both treatment groups. Similarly, the number of mRNA transcripts associated with folliculogenesis and steroidogenesis increased significantly in the high-dose treatment group. In addition, the level of growth differentiation factor 9 (GDF9) mRNA increased significantly in a dose-dependent manner. However, the levels of anti-Müllerian hormone (Amh) mRNA were considerably higher in the low-dose group and lower in the high-dose group, demonstrating that the detailed regulation of this gene is affected by AgNP dose. Analysis of the phosphatidylinositol 3-kinase signaling pathway revealed that compared to a 0.05 mg/kg, a AgNP exposure at 0.5 mg/kg significantly enhanced the PI3K/AKT/mTOR pathway and impacted Ampk signaling in a distinct manner. These findings suggest that AgNPs increase follicular development and deplete the follicular reserve, resulting in a phenomenon known as \"burnout\".</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 4","pages":"745-758"},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Defect of iNKT Cells Mediates Mitochondrial Dysfunction Through IL-6/STAT3 Signaling to Induce Atrial Inflammation and Fibrosis to Aggravate Postoperative Atrial Fibrillation.","authors":"Xiao Tian, Guangshu Tian, Zhishuo Liu, Lihua Lv, Lin Xia, Lihua Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Atrial inflammation and fibrosis are the pathogenesis of postoperative atrial fibrillation (POAF). It has been reported that invariant natural killer T (iNKT) cells can coordinate tissue inflammation, but whether it can regulate POAF is still unknown. A sterile pericarditis (SP) model was constructed on C57BL/6J mice and Jalpha18-/- mice to simulate POAF. Intraperitoneal injection of anti-interleukin (IL) -6 neutralizing antibody (anti-IL-6) was used for intervention, and atrial fibrillation (AF) was induced by transesophageal sinus atrial node pulse pacing. The levels of iNKT cells and IL-6/signal transducer and activator of transcription 3 (STAT3) signaling pathway were detected by flow cytometry and western blot. HE stain, Masson stain, and immunohistochemistry were used to evaluate the process of inflammation and fibrosis in atrial tissue. The calcium homeostasis and function of atrial mitochondria were evaluated by biochemical detection and fluorescent staining. The expression of iNKT cells was up-regulated in SP mice. The defect of iNKT cells increased the AF induction rate and duration of SP mice, enhanced AF susceptibility, aggravated atrial electrical remodeling, promoted inflammatory cell infiltration and fibrosis, and increased inflammatory factors and fibrotic proteins. Compared with SP mice, iNKT cell defects also aggravated endoplasmic reticulum-mitochondrial calcium coupling disorder, mitochondrial calcium homeostasis imbalance, reduced mitochondrial DNA (mtDNA), adenosine triphosphate (ATP) content, and mitochondrial complex enzyme activity, and increased IL-6 and STAT3 phosphorylation levels. Anti-IL-6 significantly inhibited IL-6/STAT3 signaling pathway, reduced AF induction rate and duration, and improved atrial mitochondrial calcium homeostasis, mitochondrial dysfunction, inflammation, and fibrosis. The deficiency of iNKT cells aggravated atrial tissue mitochondrial dysfunction, inflammation, and fibrosis in POAF mice via activating IL-6/STAT3 axis, and aggravated AF susceptibility.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 4","pages":"679-697"},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Peptides in Probiotic Fermented Foods: Structure-Activity Relationships and Cardiometabolic Protective Effects.","authors":"Cheng Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bioactive peptides generated during probiotic fermentation have emerged as a complex class of food-derived molecules with multifaceted physiological effects relevant to cardiometabolic health. Recent advances in peptidomics, structural analysis, and mechanistic evaluation have revealed that fermentation with lactic acid bacteria, Bacillus species, or mixed cultures produces highly diverse peptide profiles whose activities depend on sequence motifs, hydrophobicity, charge distribution, and resistance to gastrointestinal degradation. These peptides modulate key pathways involved in vascular regulation, glucose metabolism, lipid handling, and inflammatory signaling. Evidence from cellular and animal models consistently demonstrates that selected short sequences inhibit angiotensin converting enzyme, enhance incretin bioactivity through dipeptidyl peptidase IV inhibition, reduce oxidative stress via direct radical scavenging and Nrf2 activation, attenuate inflammatory cascades by neutralizing endotoxin or interfering with immune receptor interactions, and influence lipid metabolism by interacting with bile acids or receptor-regulated transcription factors. Human trials, although heterogeneous in design and outcomes, suggest modest improvements in blood pressure, glucose tolerance, and lipid measures in specific populations, with notable geographical and genetic variability. Controversy remains regarding effect size, reproducibility, and translation of in vitro potency to physiological relevance due to variability in peptide abundance, digestion stability, and differences in habitual diet. Despite such limitations, emerging strategies in controlled fermentation, peptide enrichment, in silico prediction, and combined functional formulations indicate strong potential for targeted development of peptide-rich foods that support cardiometabolic resilience. Continued integration of structural analysis, mechanistic validation, and rigorously designed clinical studies will be essential to clarify their role within food-based preventive strategies.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 4","pages":"625-644"},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Exhaustion, p38 MAPK/Rac1 GTPase/MLKL Signaling, and Ca2+ Influx Mediate Solasodine-Triggered Eryptosis.","authors":"Iman A Alajeyan, Jawaher Alsughayyir, Mohammad A Alfhili","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Solasodine (SOL) is a steroidal glycoalkaloid that shows a wide range of biological effects, most notably anticancer activities. Eryptosis is the programmed cell death of erythrocytes that leads to anemia. Specifically, chemotherapy-induced anemia can be precipitated in part by eryptosis triggered by anticancer agents. We hypothesize that the cytotoxic effects of SOL observed in cancer cells are nonspecific and extend to human erythrocytes. Eryptosis following SOL exposure was detected by fluorescence-assorted cell sorting analysis in erythrocytes from healthy volunteers. Phosphatidylserine (PS) translocation and cellular volume were measured using annexin-V-FITC and forward scatter (FSC), respectively. Fluo-4/AM was used to detect cytoplasmic Ca2+ and H2DCFDA was employed to probe oxidative stress. Hemolysis was also assessed by hemoglobin leakage. In addition, different incubation media and inhibitors were tested for their potential influence on SOL activity. Exposure to SOL led to modest but significant hemolysis and was paralleled by significant PS translocation, elevated FSC, and echinocyte morphology. Energy restitution through ATP, guanosine, and adenine significantly reversed PS translocation as did the removal of extracellular Ca2+ and the dissipation of the cell membrane K+ gradient. Co-treatment of erythrocytes with SOL and SB203580, NSC 23766, necrosulfonamide, caffeine, and melatonin significantly inhibited SOL-induced PS translocation. In conclusion, SOL is a novel pro-eryptotic compound whose activity is mediated through energy exhaustion, Ca2+ influx, and cytosolic KCl depletion, and requires p38 MAPK/Rac1 GTPase/MLKL signaling. Metabolic substrates, cation channel modulators, and targeted inhibition provide protective adjuncts to improve the therapeutic index of SOL as it advances toward translational applications.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 4","pages":"723-732"},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nootkatone Attenuates Oxidative Stress, Focal Adhesion Abundance, and Profibrotic Gene Expression in Human Keloid Fibroblasts.","authors":"W Wang, Y Li, M Liu, C Wang, H Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Keloids are driven by persistent fibroblast activation characterized by excessive matrix deposition, abnormal motility, and oxidative/inflammatory signaling. Nootkatone, a natural sesquiterpenoid present in grapefruit, has reported antioxidant and anti-inflammatory activities, but its effects on human keloid fibroblasts (HKFs) remain unclear. SV40-immortalized HKFs and non-keloid HSFs were exposed to nootkatone. Dose-response analysis showed that HKFs were more sensitive to nootkatone than HSFs; therefore, 20 and 40 microg/ml nootkatone (hereafter termed NKT20 and NKT40, respectively) were selected for subsequent HKF-focused assays, including wound closure, Transwell invasion, immunofluorescence analyses of F-actin organization, alpha-SMA, vinculin-positive focal adhesions, and intracellular reactive oxygen species (ROS), as well as RT-qPCR assays for extracellular matrix- and inflammation-related genes. HKFs were more sensitive to nootkatone than HSFs in the viability assay. Nootkatone reduced scratch-wound closure and Transwell invasion, decreased phalloidin signal, cell aspect ratio, alpha-SMA intensity, vinculin-positive focal adhesion counts, and intracellular ROS. NKT20 reduced the mRNA expression of COL1A1, COL3A1, and FN1, whereas NKT20 and NKT40 reduced IL8 and HMGB1. Nootkatone attenuated multiple profibrotic features in an SV40-immortalized HKF model, including motility-associated readouts, cytoskeletal organization, focal adhesion abundance, oxidative stress, and extracellular matrix/ inflammatory gene expression. These findings support further mechanistic evaluation of nootkatone in primary, non-immortalized, multi-donor keloid fibroblast models. Key words Nootkatone \" Keloid fibroblast \" Oxidative stress \" Focal adhesion \" alpha-SMA \" Extracellular matrix.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":" ","pages":"None"},"PeriodicalIF":2.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum 25(OH)D Concentrations and Glucose-Lipid Metabolism in Women With Gestational Diabetes Mellitus: Analysis of A NHANES 2007-2018.","authors":"F Zhang, L Wang, Z-Y Dong, S-H Lv, X-J Zheng, L-M Chen, X-F Yuan, H-J Shi","doi":"10.33549/physiolres.935791","DOIUrl":"10.33549/physiolres.935791","url":null,"abstract":"<p><p>Vitamin D is implicated in multiple metabolic processes, however, the dose-dependent relationship between serum 25-hydro-xyvitamin D [25(OH)D] concentrations and glucose-lipid metabolism remains unclear among women with a history of gestational diabetes mellitus (GDM). This study aimed to assess both linear and non-linear relationships between serum 25(OH)D levels and indicators of insulin resistance and lipid metabolism in this high-risk group. Data from 1,876 women with prior GDM were obtained from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). Weighted linear regression models were applied to assess associations between serum 25(OH)D and metabolic markers, while restricted cubic spline models were used to examine non-linear relationships. Analyses were adjusted for age, ethnicity, body mass index (BMI), education, and lifestyle factors. Following multivariate adjustment, each 10 nmol/l increase in serum 25(OH)D was associated with a decrease in HOMA-IR by 0.017 units (95 % CI: -0.026, -0.007), an increase in HDL-C by 0.127 mg/dl (95 % CI: 0.102, 0.153), and a reduction in total cholesterol of 0.007 mmol/l (95 % CI: -0.009, -0.004). Restricted cubic spline analysis demonstrated a U-shaped relationship between 25(OH)D and LDL-C (p for non-linearity<0.001), with inflection point at ~50 nmol/l. The inverse association between 25(OH)D and HOMA-IR was significant in non-Hispanic white individuals (beta=-0.020, p=0.008) but not in non-Hispanic Black individuals (beta=0.009, p=0.584). The positive association between 25(OH)D and HDL-C was strongest in women with normal BMI (beta=0.114). Among women with a history of GDM, serum 25(OH)D levels were inversely associated with insulin resistance and positively associated with HDL-C. A non-linear, U-shaped relationship was observed with LDL-C. These associations varied by race/ethnicity and BMI, the potential relevance of vitamin D status in in the long-term metabolic management of individuals following GDM. Key words 25-hydroxyvitamin D \" Dose-response relationship \" Gestational diabetes mellitus \" Insulin resistance \" Lipid metabolism.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"457-470"},"PeriodicalIF":2.8,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Age and Grip Strength, Phase Angle, and Impedance Rate Measured by Bioelectrical Impedance Analysis in Japanese Individuals Aged 15-18 Years.","authors":"K Oshita, Y Ishihara, T Horai, T Uno, S Murai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although muscle mass increases during puberty, it plateaus in girls and slowly increases in boys after around 15 years of age. This study investigated the relationship between phase angle and impedance ratio as indicators of muscle quality and age in Japanese individuals aged 15-18 years and examined their relationship with grip strength. Participants included 838 high school, college, or university students (534 boys, 304 girls). Body composition, phase angle, and impedance ratio were measured using a multi-frequency bioelectrical impedance analyzer. Phase angle was calculated from the resistance and reactance to a 50-kHz alternating current, while impedance ratio was calculated from the impedance to 5- and 250-kHz currents. Grip strength was measured using a Smedley dynamometer. Significant effects of age were observed for body size, fat-free mass, grip strength, phase angle, and impedance ratio in the boys. Compared to 16-year-olds, 17-year-olds showed a significantly higher phase angle and significantly lower impedance ratio in whole body, upper limb, and lower limb. In contrast, no significant main effects of age were observed for any of these measures in the girls. Phase angle and impedance ratio were significantly correlated with grip strength at each age in both sexes. These results suggest that phase angle and impedance ratio can be used to assess muscle strength at any age during late adolescence. However, age-specific values may be preferable for boys in late adolescence when using the reference or percentile values for phase angle and impedance ratio. Key words Muscle quality \" Muscle mass \" Muscle strength \" Puberty \" Adolescence.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"545-555"},"PeriodicalIF":2.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Rosuvastatin on Formalin-Induced Nociceptive Behavior in an Experimental Rat Model of Metabolic Syndrome.","authors":"M García-Paz, J López-Canales, M Toledo-Blas, A Franco-Vadillo, H Flores-Herrera, O López-Canales, M Paredes-Carbajal, J Lozano-Cuenca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to determine the effect of rosuvastatin (10 mg/kg/day, p.o.) on the flinching nociceptive behavior produced by subcutaneous injection of 0.5 % formalin in the dorsum of the right hind paw from Wistar rats submitted to a 16-week treatment, including a standard rat chow diet (STD-diet) or a high fat-diet (HF-diet). At three days post-treatment, the formalin-induced nociceptive response was assessed for 1 h. Compared to the STD-diet, the HF-diet significantly increased the number of flinches in the second phase of the formalin test, as well as inducing higher body weight and levels of glucose, total cholesterol, triglycerides, insulin and blood pressure. Rosuvastatin significantly decreased the formalin-induced nociceptive behavior after both diets and significantly reduced those metabolic parameters in rats with a HF- but not STD-diet. Key words High-fat diet \" Nociception \" Metabolic syndrome \" Formalin test.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"585-595"},"PeriodicalIF":2.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}