Physiological research最新文献

{"title":"Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance.","authors":"Z Holubová, D Kala, V Čapek, N Profantová, B Splítková, J Šanda, Yeva Prysiazhniuk, K Jiránková, M Kudr, P Kršek, M Kynčl, J Otáhal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to quantitatively characterize MRI signal-intensity (SI) abnormalities in focal cortical dysplasia (FCD) and to compare expert visual lesion delineation with objective SI metrics across conventional structural MRI sequences and quantitative T1 mapping (qT1). Thirteen pediatric patients with histologically confirmed FCD type I or II underwent presurgical MRI including 3D T1-weighted, T2-weighted, FLAIR, and qT1 sequences. Two expert-defined lesion masks were generated: a conservative feature-focused mask (L1) and a broader contextual mask reflecting overall radiological judgement (L2). Signal-intensity values were extracted from lesions, perilesional zones, and contralateral homologous regions, and spatial correspondence with the resection cavity was evaluated using the Dice score. L2 delineations were substantially larger and showed markedly higher overlap with resected tissue than L1, suggesting that expert contextual assessment captures clinically relevant but quantitatively subtle abnormalities. In contrast, L1 showed stronger and more consistent SI abnormalities, particularly on T2-weighted and FLAIR images, indicating that expert visual judgement and quantitative SI metrics do not fully converge. Perilesional tissue closely resembled healthy brain, with only minimal SI gradients beyond the lesion border. Quantitative T1 mapping provided limited additional value over conventional T1-weighted imaging for the detection of white-matter abnormalities. These findings indicate that expert assessment and quantitative MRI capture complementary but non-identical aspects of FCD pathology, and suggest that future automated detection models should combine quantitative features with multiple layers of radiological expertise. Key words Focal cortical dysplasia \" Signal intensity \" Structural MRI \" Pediatric \" Quantitative T1.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"597-612"},"PeriodicalIF":2.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Injection of miR-1/133 Antagonist Notably Accelerated the Healing Process of Exercise-Induced Skeletal Muscle Injury.","authors":"X Liu, M Yuan, N Zhang, J Xing","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Exercise-induced muscle damage (EIMD) significantly impacts daily work and life. The rapid promotion of repair for EIMD is worthy of attention. This study aimed to investigate the effect and mechanism of microRNAs in treating EIMD. By establishing an acute skeletal muscle injury model, we determined the key time point for skeletal muscle injury repair and the time-specific changes in MRTF-A/Pax7/SRF and muscle regeneration factors during the repair process. MicroRNAs antagonists were injected to verify the targeting relationship between miR-1/133a and MRTF-A/Pax7/SRF. A single bout of acute eccentric exercise caused significant damage to the morphological ultrastructure of rat gastrocnemius muscles, with the most severe injuries occurring 72 h after exercise. At this particular time point, it was identified as crucial for damage repair. Both miR-1-3p and miR-133a-3p collectively targeted and suppressed the protein translation of MRTF-A, Pax7, and SRF. Furthermore, both miR-1-3p and miR-133a-3p antagonists targeted the MRTF-A/Pax7 axis as well as the MRTF-A/SRF axis. MiR-1-3p antagonists primarily promote muscle proliferation and differentiation, while miR-133a-3p antagonists mainly promote differentiation while inhibiting atrophy. Combined injection effectively promote both muscle proliferation and differentiation while inhibiting atrophy, thereby facilitating damage repair in skeletal muscle fiber structure. Key words Exercise \" Muscle damage \" Skeletal muscle regeneration \" MRTF-A \" Pax7 \" SRF.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"569-584"},"PeriodicalIF":2.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Duration of High-Fat Feeding on the NAD+/Sirtuins/PGC1alpha Axis in Relation to Oxidative Stress in Rat Skeletal Muscle.","authors":"X Liu, Y Zheng, X Zhang, W Feng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study examined the effects of varying durations of high-fat diet (HFD) exposure on oxidative stress and the NAD+/Sirtuins/PGC1alpha signaling pathway in rat skeletal muscle. Thirty-two male Sprague-Dawley rats were randomly assigned to either a control group or HFD groups with exposure periods of 4, 8, or 12 weeks. Outcome measures included body weight, inflammatory markers (IL-6, TNF-alpha, MCP-1), oxidative stress parameters (MDA, SOD, GSH), apoptotic activity, and protein expression levels of key components within the signaling pathway. The results demonstrated that body weight and systemic inflammation progressively increased with the duration of HFD intake. Markers of oxidative stress became significantly elevated by week 8 and further deteriorated by week 12, characterized by increased malondialdehyde (MDA) levels, diminished antioxidant capacity (reduced SOD and GSH), and enhanced apoptosis. A reduction in Sirt3 expression and increased acetylation of PGC1alpha were detected at 8 weeks, while by 12 weeks, dysregulation extended across the entire NAD+/Sirt1/PGC1alpha pathway. These alterations were associated with exacerbated oxidative damage. The findings suggest that the duration of HFD exposure plays a critical role in the development of skeletal muscle oxidative stress through progressive and time-dependent impairment of the NAD+/Sirtuins/PGC1alpha pathway. Key words High-fat diet \" Skeletal muscle \" Oxidative stress \" Obesity \" NAD+ \" PGC1-alpha.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"557-567"},"PeriodicalIF":2.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Assisted Cerium-Doped Zeolite Nanocomplex Attenuates Adenomyosis via Wnt/beta-Catenin Pathway Inhibition and IGFBP5 Downregulation in SFRP4+ NKT Cells.","authors":"X Li, J Hu, C Feng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adenomyosis is a chronic gynecological disorder characterized by ectopic endometrial tissue within the myometrium, leading to pelvic pain, menorrhagia, and infertility. Increasing evidence implicates dysregulated Wnt/beta-catenin signaling and aberrant activation of SFRP4+ natural killer T (NKT) cells in disease progression. This study reports the ultrasound-assisted synthesis of a cerium-doped zeolite nanocomplex (Ce-ZNC) and evaluates its therapeutic efficacy in experimental models of adenomyosis. Ce-ZNC was synthesized via an ultrasound-assisted doping approach and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and polydispersity index (PDI) analysis. In vitro studies were conducted on human peripheral blood mononuclear cell (PBMC)-derived SFRP4+ NKT cells. In vivo efficacy was evaluated in a murine adenomyosis model. IGFBP5 expression and Wnt/beta catenin signaling components were analyzed by RT-qPCR and Western blotting. Histological and cytokine analyses were performed to assess fibrosis and inflammation. Ce-ZNC exhibited spherical morphology with nanoscale dimensions and good colloidal stability. Treatment resulted in a dose-dependent suppression of IGFBP5 expression and inhibition of Wnt/beta-catenin signaling. In vivo administration significantly reduced uterine fibrosis, glandular invasion, and inflammatory cytokine levels. These findings suggest that Ce-ZNC exerts immunomodulatory and anti-fibrotic effects in adenomyosis. While promising, further studies are required to elucidate biodistribution, long-term safety, and translational potential in human models. Key words Adenomyosis \" Cerium-doped zeolite \" Nanomedicine \" Wnt/beta-catenin pathway \" IGFBP5 \" SFRP4+ NKT cells \" Inflammation \" Fibrosis \" Ultrasound-assisted synthesis.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"499-506"},"PeriodicalIF":2.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin.","authors":"S Yan, X Xiang, W Hua","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study assessed the impact of gallic acid plus vitamin C on systemic oxidant stress, inflammation, hepatic and renal histology of rats with type 2 diabetes mellitus. Twenty five albino male rats were allotted into five categories of five rats each and treated hereafter as: control and diabetic group (fed rat diets and water), vitamin C (diabetic treated rats administered vitamin C, 50 mg/kg), gallic acid (diabetic treated rats administered gallic acid at 20 mg/kg), gallic acid plus vitamin C (diabetic treated rats administered 20 mg/kg gallic acid and 50 mg/kg vitamin C). The study duration was forty two days. The diabetic group had significant raise (P<0.05) of fasting glucose, glycated hemoglobin, insulin resistance scores, oxidative stress and inflammatory markers (in the liver, kidney and serum), alteration of relative liver and kidney weights, liver and kidney function indices, significant decrease (P<0.05) in total hemoglobin, serum insulin, insulin sensitivity and pancreatic beta cell function scores, body weights and pathological changes in their liver and kidney histology. These changes were ameliorated following supplementation of the diabetic group with gallic acid, vitamin C and gallic acid plus vitamin C combined treatment. Intervention with vitamin C was more efficacious than gallic acid. However, combined treatment of gallic acid plus vitamin C was more efficacious than the single treatments in modulating systemic and local oxidative stress, inflammation and in restoring the altered liver and kidney histology of the diabetic rats. Key words Antioxidants \" Type 2 diabetes mellitus \" Diabetic liver disease \" Diabetic kidney complication \" Natural products.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"471-483"},"PeriodicalIF":2.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Senescence and Osteoporosis-Associated microRNAs in Human Bone and Their Correlations With Clinical Parameters of Osteoporotic Patients.","authors":"K Vrablikova, P Hoza, H Parova, M Rybar, J Kaur, S Khosla, D Monroe, P Sauer Mykiskova, V Palicka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteoporosis is an age-related disease associated with impaired bone remodeling and cellular senescence. MicroRNAs (miRNAs) play an important regulatory role in these processes. This study aimed to identify senescence-associated miRNAs in human osteoporotic bone tissue and to assess their relationship with clinical parameters. A total of 46 patients undergoing total hip arthroplasty were included in this single-center cross-sectional study, representing a relatively large and unique cohort of human bone tissue samples: 21 with osteoporotic proximal femur fracture and 25 with elective arthroplasty for osteoarthritis as controls. Total RNA was isolated from femoral neck biopsies, and the relative expression of 11 selected miRNAs was quantified by qRT-PCR and expressed using 2^-DeltaDeltaCt method. Data were analyzed using t-tests, correlation analysis, and generalized linear models (GLM). MiR-106a-5p was significantly upregulated in osteoporotic patients, whereas miR-34a-5p, miR-218-5p, and miR-155-5p were significantly downregulated. After adjustment for clinical variables, miR-106a-5p remained independently positively associated with osteoporosis, while miR-34a-5p and miR-218-5p showed independent negative associations. MiR-92a-3p and miR-181a-5p became significantly associated with osteoporosis only after adjustment. Network analysis linked the dysregulated miRNAs to genes involved in DNA damage response and cell-cycle control. Osteoporosis is associated with a specific senescence-related miRNA signature in human bone tissue. Integration of molecular and clinical data improved the interpretation of miRNA-disease associations and supports the potential of selected miRNAs as biomarkers of bone aging and osteoporosis. Key words Cellular senescence \" Bone metabolism \" Osteoporosis \" Bone biopsies \" miRNA.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"521-532"},"PeriodicalIF":2.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.","authors":"J Zhiang, Q Song","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this research was to examine the effects of an 8-week sprint interval training (SIT) intervention alongside caffeine (CAF) supplementation on the physiological adaptations related to the health of obese men. Thirty obese men volunteered to take part in this research and were randomly assigned to three distinct groups: Caffeine plus SIT (CAF+SIT, 6 mg·kg-1 body mass, n=10), Placebo plus SIT (PL+SIT, 6 mg·kg-1 body mass in cellulose, n=10), and Control (CON, n=10). The participants in the caffeine and placebo groups ingested their supplements three times weekly, one hour prior to each SIT session over a period of eight weeks. Lower body strength, and cardiorespiratory fitness as well as body fat were assessed at baseline and following the intervention. Additionally, blood samples for evaluating fasting glucose and lipid profiles were collected 48 h before and after the SIT intervention. Both the CAF+SIT and PL+SIT groups demonstrated notable changes (p<0.05) in the assessed variables after the 8-week intervention period. Furthermore, the CAF+SIT group exhibited significantly greater adaptive responses (p<0.05) compared to the PL+SIT group in terms of fat mass reduction (Standardized mean difference [SMD]=-0.58), strength improvement (SMD=0.36), and cardiorespiratory fitness enhancement (SMD=0.41), as well as modifications in fasting glucose (SMD=-0.57), HDL (SMD=0.18), LDL (SMD=-0.80), cholesterol (SMD=-0.53), triglyceride (SMD=-0.48) and non-HDL (SMD=-1.14) following the intervention. The administration of CAF prior to SIT led to more significant decreases in fat mass and enhancements in strength and cardiorespiratory fitness. Additionally, it resulted in more notable alterations in fasting glucose and lipid profiles among obese men, thereby elucidating the beneficial effects of CAF when combined with SIT to enhance men's health. Key words Interval intervention \" Supplementation \" Obesity \" Health.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"533-544"},"PeriodicalIF":2.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothalamic Inflammation as a Critical Link Between Metabolic Dysfunction and Impaired Endometrial Receptivity in Obese Polycystic Ovary Syndrome.","authors":"C Sun, Y Han, Z Pan, J Li, X Cheng, M Sun, Y Wang, H Kuang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Obese polycystic ovary syndrome (PCOS) involves insulin resistance (IR) and impaired endometrial receptivity, potentially driven by hypothalamic inflammation. We investigated if inhibiting the hypothalamic Toll-like receptor 4 (TLR4)/IkappaB kinase beta (IKKbeta) pathway could ameliorate IR and improve endometrial receptivity in an obese PCOS rat model. An obese PCOS rat model was established using letrozole and high-fat diet. Rats were divided into control, PCOS, and three intervention groups: PCOS + intracerebroventricular (i.c.v.) TAK242 (central TLR4 inhibitor), PCOS + intraperitoneal (i.p.) TAK242 (systemic inhibitor), and PCOS + Metformin. We assessed hypothalamic inflammation (TLR4/IKKbeta pathway), metabolic parameters (body weight, OGTT, ITT, HOMA-IR), systemic inflammation, and reproductive phenotypes. Endometrial receptivity was evaluated at pregnancy day 6 by uterine morphology, histology, pinopode development (SEM), and receptivity markers (BMP2, VEGF, IGFBP-1). The obese PCOS model successfully induced hypothalamic inflammation (activated TLR4/IKKbeta pathway), systemic inflammation, profound IR, and impaired endometrial receptivity (poor decidualization, sparse pinopodes, suppressed receptivity markers). Central (i.c.v.) TAK242 administration was most effective, significantly suppressing the hypothalamic TLR4/IKKbeta pathway, attenuating weight gain, normalizing insulin sensitivity, and, critically, restoring endometrial receptivity. Metformin also improved IR and receptivity, but was less potent at inhibiting the hypothalamic TLR4/IKKbeta pathway. Systemic (i.p.) TAK242 showed the least efficacy, particularly on metabolic and endometrial outcomes. Hypothalamic inflammation (TLR4/IKKbeta pathway) appears to be a critical mechanism linking IR and impaired endometrial receptivity in obese PCOS. Targeted central inhibition was more effective than systemic inhibition, suggesting this pathway is a novel therapeutic target. Key words Polycystic ovary syndrome (PCOS) \" Hypothalamic inflammation \" Insulin resistance \" Endometrial receptivity \" TLR4/IKKbeta pathway.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"485-497"},"PeriodicalIF":2.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects and Mechanisms of Action of Acupuncture on Bone and Lipid Metabolism in a Rat Model of Postmenopausal Osteoporosis.","authors":"S-N Zhang, C-C Zhang, L-H Jiang, G Ouyang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigated the effects of acupuncture on bone and lipid metabolism in a rat model of postmenopausal osteoporosis (PMOP). Thirty-two female Sprague-Dawley rats were randomly assigned to four groups: blank control, sham-operated, model (ovariectomy), and acupuncture treatment (ovariectomy plus acupuncture). Following treatment, bone mineral density (BMD), bone tissue morphological changes with quantitative histomorphometry, serum bone metabolism markers, estradiol (E2) levels at multiple time points, body mass index (BMI), blood lipid indicators, inflammatory factors, and gut microbiota composition were measured in each group. Acupuncture increased femoral BMD after adjusting for femoral shaft thickness (P<0.05) and improved trabecular bone structure, with significant rises in trabecular number, thickness, and bone volume fraction (P<0.05). Serum osteoprotegerin levels increased and osteoclast markers decreased. Serial E2 measurements showed progressive restoration from week 4. Acupuncture reduced BMI (P<0.05), with BMI changes negatively correlating with BMD improvements (r=-0.68, P<0.01). Lipid metabolism and inflammatory markers were significantly improved (P<0.05). Gut microbiota analysis indicated increased abundance of Lactobacillus and Bifidobacterium and decreased pathogenic bacteria (P<0.05). Liquid chromatography-mass spectrometry suggested acupuncture may promote osteogenic differentiation via upregulation of the cAMP-PKA-CREB pathway. Overall, acupuncture effectively enhances bone and lipid metabolism in PMOP rats through hormonal regulation, metabolic modulation, and gut microbiota optimization. Key words Acupuncture \" Postmenopausal osteoporosis \" Bone metabolism \" Lipid metabolism \" Estradiol \" Gut microbiota \" cAMP-PKA-CREB pathway.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"507-519"},"PeriodicalIF":2.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipocytokine Profiles in Type 2 Diabetes Mellitus and Autoimmune Thyroid Disease: Associations With Metabolic and Hormonal Parameters.","authors":"I Jochmanová, Z Schröner, Š Sotak, Marek Felšöci, D Petrášová, M Mitníková, I Bertková, H Wagnerová, I Lazúrová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) and autoimmune thyroid disease (AITD) are complex disorders involving metabolic, immune, and hormonal dysregulation. Adipocytokines from adipose tissue influence metabolism, inflammation, and immune regulation. We investigated adiponectin, resistin, and visfatin in relation to thyroid, glucose, and metabolic parameters in adults with T2DM, AITD, both conditions, and healthy controls. A total of 385 adults were recruited. Clinical, anthropometric, and laboratory parameters were assessed, including glycemia, glycated hemoglobin (HbA1c), free thyroxine (fT4), thyroid-stimulating hormone (TSH), thyroid antibodies, and serum levels of adiponectin, resistin, and visfatin. Correlation and regression analyses were performed, including models adjusted for age, sex, and BMI. Adiponectin was higher in AITD than T2DM (p=0.012), resistin was higher in T2DM&AITD than controls (p=0.004), and visfatin was lower in T2DM than other groups (p<0.001). In T2DM&AITD, adiponectin correlated positively with age and fT4 and negatively with BMI (p=0.028, p=0.034). Resistin correlated inversely with TSH in AITD (p=0.033). Visfatin correlated inversely with thyroid volume in T2DM (p=0.003) and with waist circumference in AITD and T2DM&AITD (p=0.007, p=0.020). After adjustment, resistin remained higher in T2DM&AITD vs. controls (p=0.013) and visfatin and adiponectin remained lower in T2DM vs. controls (p=0.049 and p=0.045, respectively). This study highlights distinct adipocytokine profiles in individuals with metabolic and autoimmune thyroid conditions. Adiponectin, resistin, and visfatin may be potential biomarkers for disease severity and metabolic dysfunction. Further research is needed to elucidate the mechanistic pathways linking adipocytokines to the pathophysiology of T2DM and AITD. Key words Type 2 diabetes mellitus \" Autoimmune thyroid disease \" Adipocytokines \" Metabolic dysfunction.</p>","PeriodicalId":20235,"journal":{"name":"Physiological research","volume":"75 3","pages":"443-456"},"PeriodicalIF":2.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}