Physiology & Behavior最新文献

{"title":"Nicotine dependence comorbid with depressive symptoms may limit immediate cognitive improvement following exercise","authors":"Teri Kim ,&nbsp;Jinwoo Han ,&nbsp;Sechang Kwon","doi":"10.1016/j.physbeh.2025.114809","DOIUrl":"10.1016/j.physbeh.2025.114809","url":null,"abstract":"<div><div>This study investigated how acute bouts of aerobic exercise versus yoga affect inhibitory control differently in smokers with nicotine dependence depending on the presence of depressive symptoms. Thirty adult smokers were equally divided into a depressed smoker group and a non-depressed smoker group based on their Beck Depression Inventory scores. Each participant underwent baseline measurements, a 30 min aerobic exercise session, and a 30 min yoga session on different days. Brainwaves were recorded at baseline and after exercise during the Go/No-Go task. Performance accuracy, response time, and event-related potential (ERP) N2 and P3 amplitudes and latencies were analyzed. The major findings showed that the non-depressed smoker group exhibited higher accuracy than the depressed smoker group after yoga, and the non-depressed smoker group's response time improved after aerobic exercise compared with baseline. The ERP analyses revealed that the depressed smoker group exhibited smaller N2 and P3 amplitudes and shorter P3 latencies than the non-depressed smoker group. The behavioral and electrophysiological data highlight a possible cognitive deficit among smokers with depressive symptoms due to comorbid depression and addiction. Aerobic exercise elicited a larger P3 amplitude than yoga, suggesting the importance of physical intensity in promoting the active engagement of neural networks associated with inhibitory control processes. These findings suggest that expecting cognitive enhancement through acute exercise in smokers with comorbid depression may be more challenging than that in general smokers.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114809"},"PeriodicalIF":2.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of CTRP14/C1QL1 in motor coordination and learning across the lifespan","authors":"Fangluo Chen ,&nbsp;Muzna Saqib ,&nbsp;Chantelle E. Terrillion ,&nbsp;Chloe Miranda ,&nbsp;Dylan C. Sarver ,&nbsp;Joseph Scafidi ,&nbsp;G.William Wong","doi":"10.1016/j.physbeh.2025.114799","DOIUrl":"10.1016/j.physbeh.2025.114799","url":null,"abstract":"<div><div>C1q/TNF-related protein 14 (CTRP14), also known as C1q-like 1 (C1QL1), is a synaptic protein predominantly expressed in the brain. It plays a critical role in the formation and maintenance of the climbing fiber-Purkinje cell synapses, ensuring that only one single winning climbing fiber from the inferior olivary neuron synapses with the proximal dendrites of Purkinje cells during the early postnatal period. Loss of CTRP14/C1QL1 results in incomplete elimination of supernumerary climbing fibers, leading to multiple persistent climbing fibers synapsing with the Purkinje cells. While this deficit impairs oculomotor learning in adult mice, the impact of CTRP14 deficiency on motor function throughout adulthood has not been examined. Here, we conduct behavioral tests on a constitutive <em>Ctrp14</em> knockout (KO) mouse model to determine whether CTRP14 is required for motor learning and function in mice across the lifespan. We show that CTRP14 deficiency does not affect grip strength, nor sprint and endurance running, in young and old mice of either sex. We performed accelerated rotarod tests on mice at 6, 12, and 18 months old to assess motor coordination and learning. No significant differences were observed between WT and <em>Ctrp14</em>-KO mice of either sex across the lifespan. Lastly, we performed complex running wheel tests to detect latent motor deficits and found that aged <em>Ctrp14</em>-KO mice have intact motor skills. Despite some limitations of the study, our data suggest that CTRP14 is dispensable for gross motor skills, coordination, and learning throughout adulthood based on the specific tests performed.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114799"},"PeriodicalIF":2.4,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating how eating behavior shapes mental health: A cross-sectional study","authors":"Öykü Peren Türk ,&nbsp;Özgür Tosun ,&nbsp;Selçuk Dağdelen ,&nbsp;Zehra Buyuktuncer","doi":"10.1016/j.physbeh.2024.114798","DOIUrl":"10.1016/j.physbeh.2024.114798","url":null,"abstract":"<div><div>This study aimed to examine the relationship between eating behavior, nutritional status and mental health. It is a cross-sectional study conducted on a sample of 360 healthy individuals aged 19–64 years. The General Health Questionnaire (GHQ-12) was used to evaluate mental health and the Three-Factor Eating Scale (TFEQ-R21) was used to assess eating behavior. The Healthy Eating Index-2015 (HEI-2015) score was calculated from participants' 24 h food recalls as an indicator of diet quality. The mean age of the participants was 26.0 ± 8.40 years, and 50.6 % were female. Multivariate logistic regression model was performed. A statistically significant relationship was found between the participants' GHQ-12 score and both their emotional eating and uncontrolled eating scores (<em>p</em> &lt; 0.001 for each). It was determined that individuals who had high levels of emotional eating and uncontrolled eating behaviors, along with higher dietary protein and lipid intake, and lower intake of long-chain fatty acids, were at a higher risk of mental health deterioration, according to the established model (R2 = 0.214). Dietary energy and nutrient intakes such as niacin, vitamin B12, folic acid, phosphorus, iron, sodium and carotene, as well as diet quality and BMI were not associated with mental health according to the model in this study. Eating behavior is associated with mental well-being, and nutritional status may be one of the underlying factors contributing to this association.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114798"},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of high-intensity interval training on insulin resistance, oxidative stress, and muscle function in a PCOS rat model","authors":"Seda Koçak ,&nbsp;Hasan Çalışkan ,&nbsp;Göktuğ Ömercioğlu ,&nbsp;Fırat Akat ,&nbsp;Deniz Billur ,&nbsp;İrem İnanç ,&nbsp;Hakan Fıçıcılar ,&nbsp;Metin Baştuğ","doi":"10.1016/j.physbeh.2024.114794","DOIUrl":"10.1016/j.physbeh.2024.114794","url":null,"abstract":"<div><div>Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders . This study aimed to investigate the effects of high-intensity interval training (HIIT) on insulin resistance, oxidative stress, soleus muscle function, and myokine levels in a PCOS rat model. Female rats were assigned to four groups: Control, PCOS, PCOS+Exercise, and Exercise (<em>n</em>=15 each). PCOS was induced by subcutaneous administration of dehydroepiandrosterone (DHEA) for 3 weeks, and exercise groups underwent HIIT for 12 weeks. Insulin resistance (HOMA-IR), serum oxidative stress markers, hormone levels (FSH, LH), soleus myokine expression, and muscle function were analyzed. Results showed that the PCOS group exhibited increased blood pressure and insulin resistance compared to controls, with a significant reduction in FSH and LH levels in the PCOS+Exercise group. Exercise improved insulin sensitivity and reduced insulin resistance in the PCOS+Exercise group. Serum oxidative stress markers did not differ significantly between groups. Soleus muscle IL-6 levels were significantly reduced in the PCOS+Exercise group. Histological analysis revealed a larger cross-sectional area of the soleus muscle in the PCOS+Exercise group compared to the PCOS group, suggesting improved muscle morphology. Furthermore, exercise improved the functional capacity of soleus muscles, as evidenced by weightlifting performance. These findings indicate that HIIT has beneficial effects on insulin resistance, reproductive hormone levels in PCOS. Exercise also shows potential in slowing oocyte loss and improving follicle health, highlighting its role as a therapeutic intervention for reproductive health in PCOS. This study suggests that HIIT could be a beneficial approach for managing PCOS, and further research is needed to better understand its underlying mechanisms and potential long-term benefits.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114794"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and loneliness in a volunteer sample of adults at a suicide prevention and fund-raising walk: A feasibility study","authors":"Carol A. Janney ,&nbsp;Jonathon Im ,&nbsp;Sabrina Ma ,&nbsp;Kathy Dollard","doi":"10.1016/j.physbeh.2024.114797","DOIUrl":"10.1016/j.physbeh.2024.114797","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness is recognized as a distinct psychological experience separate from depression. This feasibility study explored the prevalence and association of depression and loneliness among adults at a suicide prevention walk, a potentially high risk and vulnerable population for depression, loneliness and suicide.</div></div><div><h3>Methods</h3><div>Adults completed anonymous loneliness, depression, and physical activity surveys. Based on Patient Health Questionnaire-2 (PHQ-2), adults were classified as screening positive (3 to 6) or negative (0 to 2) for depression. T-tests determined if the revised UCLA Loneliness Score (ULS) differed by depression screening status.</div></div><div><h3>Results</h3><div>Of the 133 survey participants, 13% screened positive for depression. Positive screens were highest for males, aged 18–35, living alone with a less active lifestyle. Participants averaged 36.8 ± 10.4 on the ULS; 11 %(n = 13) and 5%(n=6) were classified as experiencing moderate and very high levels of loneliness, respectively. Loneliness was significantly greater for those who screened positive for depression (49±9) compared to those who screened negative (35 ± 9)(<em>p</em> &lt; 0.001). ULS and PHQ-2 were positively correlated (r=0.70, <em>p</em> &lt; 0.01). Active participants reported less loneliness than less active participants(<em>p</em> &lt; 0.01).</div></div><div><h3>Limitations</h3><div>The findings may be biased due to the volunteer sample composed primarily of female Caucasians.</div></div><div><h3>Conclusion</h3><div>In a sample that may be at higher risk for depression due to suicide attempts or being suicide loss survivors, 13 % screened positive for depression. Loneliness scores were not elevated in this population compared to national estimates. Suicide awareness events may be an efficient and cost-effective public health measure for the screening and appropriate follow-up of physical activity, depression and loneliness.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114797"},"PeriodicalIF":2.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary behaviors negatively related to depressive symptoms in college students: The roles of type and duration of sedentary behaviors","authors":"Zehan Xia ,&nbsp;Teck Cheng Tan ,&nbsp;Yiting Liu ,&nbsp;Jiaxin Zheng ,&nbsp;Zhongbin Li ,&nbsp;Qian Gu ,&nbsp;Tao Huang","doi":"10.1016/j.physbeh.2024.114796","DOIUrl":"10.1016/j.physbeh.2024.114796","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine the associations of different types and duration with sedentary behaviors and depressive symptoms among college students.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at a university in Shanghai, China, utilizing convenience sampling to recruit 3,190 participants (mean age 20.06 ± 1.23 years). Sedentary behaviors were self-reported using a structured questionnaire detailing the average daily time spent in different types of sedentary behaviors. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CESD-10). Linear regression models were conducted to analyze the associations between sedentary behaviors and depressive symptoms with adjustment for relevant covariates.</div></div><div><h3>Results</h3><div>Recreational screen-based sedentary behaviors were significantly associated with higher depressive symptom scores on both weekdays (B = 0.523, 95 % CI= 0.409 to 0.637, <em>p</em> &lt; 0.001) and weekends (B = 0.313, 95 % CI= 0.221 to 0.406, <em>p</em> &lt; 0.001). Study-related sedentary behaviors showed no significant association on weekdays (<em>p</em> &gt; 0.05), but were significantly associated with depressive symptoms on weekends (B = 0.084, 95 % CI= 0.017 to 0.151, <em>p</em> &lt; 0.05). Other types of sedentary behaviors (e.g., commuting and eating) also showed a positive association with depression scores on both weekdays and weekends (<em>p</em> &lt; 0.05). Longer durations of recreational screen-based and study-related sedentary behaviors were associated with higher depressive symptom scores (both <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The study suggests that the associations between sedentary behaviors and depressive symptoms vary by the type and context of sedentary behavior. Additionally, the duration of each sedentary behavior bout is a significant influencing factor.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114796"},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived fatigue does not alter effort-based decision making but does undermine confidence in the ability to perform physical actions","authors":"Aaron Greenhouse-Tucknott ,&nbsp;James G. Wrightson ,&nbsp;Sam Berens ,&nbsp;Jeanne Dekerle ,&nbsp;Neil A. Harrison","doi":"10.1016/j.physbeh.2024.114792","DOIUrl":"10.1016/j.physbeh.2024.114792","url":null,"abstract":"<div><div>Fatigue may affect the decision to deploy effort (cost) for a given rewarded outcome (benefit). However, it remains unclear whether these fatigue-associated changes can be attributed to simply feeling fatigued. To investigate this question, twenty-two healthy males made a series of choices between two rewarded options: a fixed, no effort option, where no physical effort was required to obtain a set, low reward vs. a variable, effortful option, in which both the physical effort requirements (i.e. different durations of a sustained contraction performed in the lower limbs) and rewards (i.e. greater monetary incentives) was varied. Effort-based choices were made under two conditions: (1) a rested (control) state, (2) a pre-induced state of perceived fatigue, evoked through physical exertion in the upper-limbs, thus controlling for the physical manifestation of fatigue (i.e. decline in muscular force production in the lower limbs) on the decision process. Though prior physical exertion increased the perception of fatigue, participants choices did not significantly differ between control and fatigue conditions. Across both conditions, participants demonstrated an anticipated aversion to effort, with greater effort requirements reducing the decision to engage in actions associated with higher rewards. However, in the fatigue state only, decision time was prolonged and self-reported confidence in individuals’ ability to perform high effort actions was reduced. The findings suggest that a perceived state of fatigue does not necessarily alter cost/benefit comparisons within effort-based decisions, but may introduce greater uncertainty within choice and reduce self-confidence. These findings evidence altered evaluative processes during decision making under conditions of fatigue.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114792"},"PeriodicalIF":2.4,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enriched environment prevents hypernociception and depression-like behavior in a psychiatric disorder and neuropathic pain comorbidity experimental condition","authors":"Priscila Medeiros ,&nbsp;Ana Carolina Medeiros ,&nbsp;Renato Leonardo de Freitas ,&nbsp;Glauce Regina Pigatto ,&nbsp;Alline Cristina de Campos ,&nbsp;Alexandre Kanashiro ,&nbsp;Norberto Cysne Coimbra","doi":"10.1016/j.physbeh.2024.114795","DOIUrl":"10.1016/j.physbeh.2024.114795","url":null,"abstract":"<div><div>Pain is a multifactorial debilitating condition associated with some psychiatric comorbidities such as generalized anxiety and depression. Concerning pharmacological treatment, which is often inefficient or associated with intense side effects, the physical and social context may be fundamental for patient's health improvement. In this sense, we sought to assess the impact of an enriched environment (EE) on neuropathic pain (NP) and depression comorbid. For this purpose, mice exposed to EE or non-enriched conditions for three weeks were submitted to either a chronic constriction injury (CCI) of the ischiadicus nervus or a sham procedure. After three weeks of EE or non-enriched exposition, allodynia (recorded by von Frey and acetone tests), hyperalgesia (recorded by hot plate test), despair behavioral response (recorded by tail suspension test), and apathy (recorded by sucrose spray test) were evaluated. Mice submitted to CCI procedure showed increased rates of hyperalgesia and allodynia, as well as depression-like behaviors compared to the sham procedure-submitted mice. Exposure to EE significantly increased pain thresholds and significantly diminished depression-related behaviors. These findings suggest that the sensory, physical, and social context can be an extra tool for controlling not only sensory-discriminative pain but also emotional pain-related psychiatric comorbidities, such as depression.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114795"},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists significantly impair taste function","authors":"Rafa Khan,&nbsp;Richard L. Doty","doi":"10.1016/j.physbeh.2024.114793","DOIUrl":"10.1016/j.physbeh.2024.114793","url":null,"abstract":"<div><div>Over 10% of the US population are prescribed glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to combat obesity. Although they decrease cravings for foods, their influence on chemosensory function is unknown. We employed state-of-the-art quantitative taste and smell tests to address this issue. The 53-item Waterless Empirical Taste Test (WETT®) and the 40-item University of Pennsylvania Smell Identification Test (UPSIT®) were completed by 46 persons taking GLP-1 RAs and 46 controls matched on age, sex, smoking behavior, and COVID-19 infection histories. Data were analyzed using analyses of variance. The WETT® scores were significantly diminished in the GLP-1 RA group relative to controls [total means (95% CIs) = 28.61 (25.66,31.56) and 40.63 (38.35,42.91), <em>p</em> &lt; 0.001, η² = 0.37]. Eighty five percent of the GLP-1 subjects scored worse than their individually matched controls. All 5 WETT® subtest scores were similarly affected (ps &lt; 0.001). Smell function, although slightly decreased on average, was not significantly impacted (<em>p</em> = 0.076). Women outperformed men on all tests. Remarkably, UPSIT® and WETT® scores were higher, i.e., better, in those reporting nausea, diarrhoea, and other GLP-1-related side effects. This study demonstrates, for the first time, that GLP-1 RAs alter the function of a major sensory system, significantly depressing the perception of all five basic taste qualities. The physiologic basis of this effect is unknown but may involve GLP-1 receptors in the brainstem and afferent taste pathways, as well as vagus nerve-related processes.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114793"},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pubertal stress accelerates copulation in adult male rats: Mitigating effects of a high-calorie diet in adulthood","authors":"Deissy Herrera-Covarrubias ,&nbsp;Antares Basulto-Natividad ,&nbsp;María Elena Hernández-Aguilar ,&nbsp;Gonzalo E. Aranda-Abreu ,&nbsp;Jorge Manzo ,&nbsp;Rebeca Toledo-Cárdenas ,&nbsp;Fausto Rojas-Durán ,&nbsp;Genaro A. Coria-Avila","doi":"10.1016/j.physbeh.2024.114791","DOIUrl":"10.1016/j.physbeh.2024.114791","url":null,"abstract":"<div><div>The pubertal phase involves significant brain reorganization, where external stressors and diet can profoundly influence long-term behavioral outcomes. In this study, we investigated the interaction between acute pubertal stress (via immune challenge) and a hypercaloric diet in adulthood on the copulatory sexual behavior of male Wistar rats. At postnatal day (PND) 35, pubertal males received a single injection of lipopolysaccharide (LPS, 1.5 mg/kg i.p.) or saline. All subjects were fed standard rat chow until postnatal week 14, during which copulatory sexual behavior was assessed from weeks 11 to 14. Then, from weeks 15 to 18, half of the animals in each group were switched to a hypercaloric cafeteria-type diet and the other half continued on standard chow, with sexual behavior of all males re-assessed during weeks 19 to 22 and under standard diet. Our results indicated that treatment with LPS during puberty accelerated copulation in adulthood, characterized by fewer mounts and intromissions per series, shorter latency to ejaculation and higher intromission ratio. Cafeteria diet alone increased mount and intromission frequency, but had no effect on ejaculations. Only intromission were affected by an interaction of treatment and diet. These findings show that LPS-induced immune stress during puberty acts as an early-life stressor with enduring consequences on copulatory timing in males, while a subchronic hypercaloric diet in adulthood may mitigate some of these effects.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114791"},"PeriodicalIF":2.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}