Physiology & Behavior最新文献_第10页

Heart and shoal: Social cues and oxytocin receptors impact stress recovery in the zebrafish 心与鱼群：社会线索和催产素受体影响斑马鱼的应激恢复。

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-06-11 DOI: 10.1016/j.physbeh.2024.114613

Leah C. Wilson, Anna Riordan, April Nussbaum, Jacob Krawitz

{"title":"Heart and shoal: Social cues and oxytocin receptors impact stress recovery in the zebrafish","authors":"Leah C. Wilson, Anna Riordan, April Nussbaum, Jacob Krawitz","doi":"10.1016/j.physbeh.2024.114613","DOIUrl":"10.1016/j.physbeh.2024.114613","url":null,"abstract":"<div><p>In many species, social interactions decrease behavioral, hormonal, and neural responses to environmental stressors. While “social buffering” and its mechanisms have received considerable attention in mammals, we know less about the phenomenon in fish. The nonapeptide oxytocin regulates social behavior across vertebrates and plays an important role in social buffering in mammals. We investigated social buffering in the zebrafish by evaluating how the social environment and oxytocin receptors impact recovery from an acute stressor. Male and female fish were briefly exposed to alarm substance and recovered either in isolation or within view of a stimulus shoal. Alarm substance did not increase social approach, but social stimuli improved behavioral stress recovery. Oxytocin receptor antagonism decreased social approach during stress recovery and impaired stress recovery exclusively in individuals with access to visual social stimuli. Our findings contribute to the growing body of evidence that social stimuli buffer stress responses in fish and suggest that oxytocin receptors may play a role in socially-buffered stress recovery across taxa.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the impact of exercise type combined with caloric restriction on quality of life–The PRONAF study 调查运动类型结合热量限制对生活质量的影响--PRONAF 研究。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2024-06-10 DOI: 10.1016/j.physbeh.2024.114614

Domingo Jesús Ramos-Campo, Miguel Ángel Rojo-Tirado, Pedro J. Benito-Peinado

{"title":"Investigating the impact of exercise type combined with caloric restriction on quality of life–The PRONAF study","authors":"Domingo Jesús Ramos-Campo, Miguel Ángel Rojo-Tirado, Pedro J. Benito-Peinado","doi":"10.1016/j.physbeh.2024.114614","DOIUrl":"10.1016/j.physbeh.2024.114614","url":null,"abstract":"<div><p>The aim of this study was to analyze the impact of endurance training (E), strength training (S), or combined training (SE), along with caloric restriction diet, compared to only diet and physical activity recommendations (C, control), on the quality of life in individuals with obesity. One hundred and twenty obese participants (61 males), aged 18–50 years, were randomly assigned to the different experimental groups, with ninety-six completing the study. The intervention period spanned 22 weeks (3 times per week). All subjects followed a hypocaloric diet, and quality of life was assessed using the SF36 questionnaire before and after the training program. A significant improvement was observed in emotional role following the S (Baseline: 85.06 ± 30.32; Post: 96.00 ± 11.06; <em>p</em> = 0.030) and SE (Baseline: 76.67 ± 35.18; Post: 91.30 ± 22.96; <em>p</em> = 0.010) programs, but not after E (Baseline: 83.33 ± 29.40; Post: 78.26 ± 35.69; <em>p</em> = 0.318) and C (Baseline: 77.01 ± 34.62; Post: 79.37 ± 37.23; <em>p</em> = 0.516). No significant main effect was observed in any other outcome measured. Overall, all groups demonstrated improvements in quality-of-life outcomes. In conclusion, any physical exercise intervention combined with caloric restriction, physical activity recommendations, and nutritional habits resulted in an enhancement of quality of life.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0031938424001598/pdfft?md5=a3e4164f09ea6da470d87d93d74c3e8c&pid=1-s2.0-S0031938424001598-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifetime stressor exposure is associated with greater rewarding effects of stress-related eating 终生暴露于压力源与压力相关的进食会产生更大的奖励效应。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2024-06-10 DOI: 10.1016/j.physbeh.2024.114610

{"title":"Lifetime stressor exposure is associated with greater rewarding effects of stress-related eating","authors":"","doi":"10.1016/j.physbeh.2024.114610","DOIUrl":"10.1016/j.physbeh.2024.114610","url":null,"abstract":"<div><p>Acute stressors tend to shift preferences toward comfort foods, yet they do not ubiquitously increase the amount of food consumed. Moreover, although many individuals eat more under stress, others eat less or show no change. Although the precise mechanisms explaining this variability in stress-related eating are unknown, they may be driven by individual differences in the rewarding effects of comfort eating, which are enhanced by greater lifetime stressor exposure. To investigate this possibility, we examined whether differences in lifetime stressor exposure predicted reductions in negative affect following snacking (i.e., negative reinforcement) and if this effect was specific to stress-related snacking or snacking in general. Participants were 26 women (23 % non-White) between 20 and 45 years old (<em>M</em> = 31), with a mean body mass index of 26, who completed three laboratory visits. Participants completed an assessment of lifetime stressor exposure (i.e., STRAIN) on the first visit and, on two subsequent laboratory visits in counterbalanced order, were given snacks after an acute social stress task (i.e., TSST) or rest period. Greater lifetime stressor exposure was related to greater post-ingestive decreases in negative affect following the acute social stressor but not following the rest period. If stress-related eating is more comforting for women with greater lifetime stressors and contributes to a stronger stress-eating association, then this may inform obesity-related clinical treatments that target behaviors and cognitions related to reward-based learning.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin Kisspeptin、孕酮和 GnRH 受体参与了 kisspeptin 诱导的脊柱前凸行为。

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-06-06 DOI: 10.1016/j.physbeh.2024.114609

Oscar González-Flores , Raymundo Domínguez-Ordóñez , Raul Jacobo Delgado-Macuil , José Luis Tlachi-López , Ailyn Luna-Hernández , Omar Montes-Narváez , James G. Pfaus , Marcos García-Juárez

{"title":"Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin","authors":"Oscar González-Flores , Raymundo Domínguez-Ordóñez , Raul Jacobo Delgado-Macuil , José Luis Tlachi-López , Ailyn Luna-Hernández , Omar Montes-Narváez , James G. Pfaus , Marcos García-Juárez","doi":"10.1016/j.physbeh.2024.114609","DOIUrl":"10.1016/j.physbeh.2024.114609","url":null,"abstract":"<div><p>The neuropeptide kisspeptin (Kiss) is crucial in regulating the hypothalamic-pituitary-gonadal axis. It is produced by two main groups of neurons in the hypothalamus: the rostral periventricular region around the third ventricle and the arcuate nucleus. Kiss is the peptide product of the KiSS-1 gene and serves as the endogenous agonist for the GPR54 receptor. The Kiss/GPR54 system functions as a critical regulator of the reproductive system. Thus, we examined the effect of intracerebroventricular administration of 3 μg of Kiss to the right lateral ventricle of ovariectomized rats primed with a dose of 5 μg subcutaneous (sc) of estradiol benzoate (EB). Kiss treatment increased the lordosis quotient at all times tested. However, the lordosis reflex score was comparatively lower yet still significant compared to the control group. To investigate receptor specificity and downstream mechanisms on lordosis, we infused 10 μg of GPR54 receptor antagonist, Kiss-234, 5 μg of the progestin receptor antagonist, RU486, or 3 μg of antide, a gonadotropin-releasing hormone-1 (GnRH-1) receptor antagonist, to the right lateral ventricle 30 min before an infusion of 3 μg of Kiss. Results demonstrated a significant reduction in the facilitation of lordosis behavior by Kiss at 60 and 120 min when Kiss-234, RU486, or antide were administered. These findings suggest that Kiss stimulates lordosis expression by activating GPR54 receptors on GnRH neurons and that Kiss/GPR54 system is an essential intermediary by which progesterone activates GnRH.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of professional experience on clinical judgment and muscular response in various neuromuscular tests 专业经验对各种神经肌肉测试中临床判断和肌肉反应的影响。

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-06-06 DOI: 10.1016/j.physbeh.2024.114602

Jorge Rey-Mota , Guillermo Escribano-Colmena , Jesús Fernández-Lucas , Jose A. Parraca , Vicente Javier Clemente-Suárez

{"title":"Impact of professional experience on clinical judgment and muscular response in various neuromuscular tests","authors":"Jorge Rey-Mota , Guillermo Escribano-Colmena , Jesús Fernández-Lucas , Jose A. Parraca , Vicente Javier Clemente-Suárez","doi":"10.1016/j.physbeh.2024.114602","DOIUrl":"10.1016/j.physbeh.2024.114602","url":null,"abstract":"<div><p>Muscle testing is an integral component in assessing musculoskeletal function and tailoring rehabilitation efforts. This study aimed i. to identify an objective evaluation system sensitive to analyze changes in different muscular conditions in different neuromuscular tests across a spectrum of professional experience levels; and ii. to analyze differences in objective parameters and clinical judgment between participants of different levels of expertise in different muscular conditions in different neuromuscular tests. Participants included 60 subjects with Level I to III expertise who performed blinded neuromuscular tests on the middle deltoid and rectus femoris muscles of 40 volunteer subjects. The methodology centered on standardizing test protocols to minimize variability, employing EMG to quantify muscle activity, thermography to capture thermographic muscular response, and digital dynamometry to measure muscular resistance. The findings revealed that while traditional methods like thermography and electromyography provide valuable insights, digital dynamometry stands out for its sensitivity in detecting muscle condition changes in neuromuscular test. Moreover, the data underscored the pivotal role of advanced training and expertise in enhancing the precision and accuracy of neuromuscular diagnostics, since there were significant differences in objective parameters and clinical judgment between participants of different levels of expertise in the different muscular conditions in Middle deltoid and Rectus femoris neuromuscular tests analyzed, presenting higher expertise participant clinical judgment like objective validated instrument.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0031938424001471/pdfft?md5=ec67e6f064ff4af650f417d4aa033599&pid=1-s2.0-S0031938424001471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracerebroventricular prokineticin 2 infusion may play a role on the hypothalamus-pituitary-thyroid axis and energy metabolism 脑室内注射促肾上腺皮质激素 2 可能会对下丘脑-垂体-甲状腺轴和能量代谢产生影响。

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-06-03 DOI: 10.1016/j.physbeh.2024.114601

Umit Yilmaz , Kevser Tanbek

{"title":"Intracerebroventricular prokineticin 2 infusion may play a role on the hypothalamus-pituitary-thyroid axis and energy metabolism","authors":"Umit Yilmaz , Kevser Tanbek","doi":"10.1016/j.physbeh.2024.114601","DOIUrl":"10.1016/j.physbeh.2024.114601","url":null,"abstract":"<div><h3>Aim</h3><p>The hypothesis of this study is to determine the effects of intracerebroventricular (icv) prokineticin 2 infusion on food consumption and body weight and to elucidate whether it has effects on energy expenditure via the hypothalamus-pituitary-thyroid (HPT) axis in adipose tissue.</p></div><div><h3>Material and Methods</h3><p>A total of 40 rats were used in the study and 4 groups were established: Control, Sham, Prokineticin 1.5 and Prokineticin 4.5 (<em>n</em>=10). Except for the Control group, rats were treated intracerebroventricularly via osmotic minipumps, the Sham group was infused with aCSF (vehicle), and the Prokineticin 1.5 and Prokineticin 4.5 groups were infused with 1.5 nMol and 4.5 nMol prokineticin 2, respectively. Food and water consumption and body weight were monitored during 7-day infusion in all groups. At the end of the infusion, the rats were decapitated and serum TSH, fT4 and fT3 levels were determined by ELISA. In addition, PGC-1α and UCP1 gene expression levels in white adipose tissue (WAT) and brown adipose tissue (BAT), TRH from rat hypothalamic tissue were determined by real-time PCR.</p></div><div><h3>Results</h3><p>Icv prokineticin 2 (4.5 nMol) infusion had no effect on water consumption but reduced daily food consumption and body weight (<em>p</em><0.05). Icv prokineticin 2 (4.5 nMol) infusion significantly increased serum TSH, fT4 and fT3 levels when compared to Control and Sham groups (<em>p</em><0.05). Also, icv prokineticin 2 (4.5 nMol) infusion increased the expression of TRH in the hypothalamus tissue and expression of PGC-1α UCP1 in the WAT and BAT (<em>p</em><0.05).</p></div><div><h3>Conclusion</h3><p>Icv prokineticin 2 (4.5 nMol) infusion may suppress food consumption via its receptors in the hypothalamus and reduce body weight by stimulating energy expenditure and thermogenesis in adipose tissue through the HPT axis.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models 研究内分泌干扰物对雌性大鼠模型中 AVP 和 OT 介导的行为和生殖过程的影响

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-06-02 DOI: 10.1016/j.physbeh.2024.114597

Krisztián Sepp , Anna László , Márta Gálfi , Marianna Radács , Miklós Mózes , Péter Hausinger , Regina Pálföldi , Médea Veszelka , Zsuzsanna Valkusz , Zsolt Molnár

{"title":"Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models","authors":"Krisztián Sepp , Anna László , Márta Gálfi , Marianna Radács , Miklós Mózes , Péter Hausinger , Regina Pálföldi , Médea Veszelka , Zsuzsanna Valkusz , Zsolt Molnár","doi":"10.1016/j.physbeh.2024.114597","DOIUrl":"10.1016/j.physbeh.2024.114597","url":null,"abstract":"<div><p>Environmental exposures may have endocrine disruptor (ED) effects, e.g., a role for halogenated hydrocarbon chlorobenzenes in increasing vasopressin (AVP), oxytocin (OT) secretion and, in association, anxiety and aggression in male rats has been shown. Our aim is to investigate whether 1,2,4-trichlorobenzenehexachlorobenzene= 1:1 (mClB) treatment of female rats also shows ED effects and reproductive biology differences, and whether AVP may have a mediator role in this? Female Wistar rats were treated (0.1; 1.0; 10.0 μg/bwkg/day) with mClB (by gastrictube) and then 30; 60; 90 days after treatment anxiety (open field test) and aggressive (resident intruder test) behaviors AVP, OT concentrations from blood plasma samples were detected by radioimmunoassay on 30; 60; 90 days. Treated female rats were mated with untreated males. Mating success, number of newborn and maternal aggression on the neonates were monitored. Results showed that AVP, OT levels; and anxiety, aggressive behaviors; and mothers' aggression towards their offspring increased significantly in relation to the duration and the dose of mClB treatment. But mating propensity and number of offspring decreased. Patterns of AVP, OT release and anxiety, aggression behaviors, and reproductive-related behaviors were correlated. Consistent with the literature, our studies confirmed the role of AVP and OT in different behavioral effects.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0031938424001422/pdfft?md5=8b676f5fec23eaadcb3dcfd2484df763&pid=1-s2.0-S0031938424001422-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141228913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High frequency heart rate variability is associated with sensitivity to affective touch 高频心率变异性与对情感接触的敏感性有关

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-06-01 DOI: 10.1016/j.physbeh.2024.114600

Ralph Pawling , Francis. McGlone , Susannah C. Walker

{"title":"High frequency heart rate variability is associated with sensitivity to affective touch","authors":"Ralph Pawling , Francis. McGlone , Susannah C. Walker","doi":"10.1016/j.physbeh.2024.114600","DOIUrl":"10.1016/j.physbeh.2024.114600","url":null,"abstract":"<div><p>C-tactile afferents (CTs) are a class of unmyelinated, mechanosensitive nerve fibre that respond optimally to skin temperature, slow moving touch typical of a caress. They are hypothesised to signal the rewarding value of affiliative tactile interactions. While CT firing frequency is positively correlated with subjective ratings of touch pleasantness, trait differences in sensitivity to the specific hedonic value of CT targeted touch have been reported.</p><p>Inter-individual differences in vagally mediated, high frequency heart rate variability (HF-HRV) have been linked to variation in visual social cognition. Thus, the aim of the present study was to examine the relationship between resting state HF-HRV and sensitivity to socially relevant CT targeted touch.</p><p>58 healthy participants first had a 5-minute electrocardiogram. They then rated the pleasantness of 5 randomly presented velocities of robotically delivered touch. Three velocities fell within (1, 3, 10 cm/s) and two outside (0.3, 30 cm/s) the CT optimal range. Each velocity was delivered twice.</p><p>On a group level, affective touch ratings were described by a negative quadratic function, with CT optimal velocities rated as more pleasant than slower and faster speeds. Simple regression analysis confirmed participants’ HF-HRV was significantly predicted by the quadratic curve fit of their touch ratings, with higher HF-HRV associated with a better quadratic fit.</p><p>These findings indicate that, in line with previous observations that higher HF-HRV is associated with enhanced sensitivity to visual social cues, trait differences in autonomic control could account for previously reported individual differences in CT sensitivity.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0031938424001458/pdfft?md5=98c7700e7940636adeee98ec7b2c1b7f&pid=1-s2.0-S0031938424001458-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin attenuates cocaine-associated place preference via the dorsal hippocampus in male and female rats 催产素可通过雄性和雌性大鼠的海马背侧减轻可卡因相关的场所偏好。

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-05-31 DOI: 10.1016/j.physbeh.2024.114599

Paige C. Bensing, Chase Moye, Kah-Chung Leong

{"title":"Oxytocin attenuates cocaine-associated place preference via the dorsal hippocampus in male and female rats","authors":"Paige C. Bensing, Chase Moye, Kah-Chung Leong","doi":"10.1016/j.physbeh.2024.114599","DOIUrl":"10.1016/j.physbeh.2024.114599","url":null,"abstract":"<div><p>Cocaine addiction is the third largest cause of overdose-related deaths in the United States. Research investigating therapeutic targets for cocaine reward processes is key to combating this issue. The neuropeptide oxytocin (OXT) has been shown to reduce cocaine reward processes, though specific mechanisms are not understood. This study examines the effect of intra-dorsal hippocampal (DH) OXT on the expression of cocaine context associations using a conditioned place preference (CPP) paradigm. In this paradigm, one of two visually distinct chambers is paired with a drug. With repeated pairings, control animals display preference for the drug-associated context by spending more time in that context at test. In the present study, four conditioning days took place where male and female rats were injected with either cocaine or saline and placed into the corresponding chamber. On test day, rats received infusions of OXT or saline (VEH) into the DH and were allowed access to both chambers. The results show that while VEH-infused rats displayed cocaine CPP, OXT-infused rats did not prefer the cocaine-paired chamber. These findings implicate the DH as necessary in the mechanism by which OXT acts to block the expression of cocaine-context associations, providing insight into how OXT may exert its therapeutic effect in cocaine reward processes.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring honey bee feeding rhythms with the BeeBox, a platform for nectar foraging insects 利用蜜蜂箱测量蜜蜂的觅食节奏，蜜蜂箱是一个觅食花蜜的昆虫平台。

IF 2.9 3区医学

Physiology & Behavior Pub Date : 2024-05-29 DOI: 10.1016/j.physbeh.2024.114598

Michel B.C. Sokolowski , Guillaume Bottet , Matthieu Dacher

引用次数: 0