Physiology & Behavior最新文献

{"title":"The role of the hypothalamus in the development of cancer cachexia.","authors":"Dimitrios Stagikas, Yannis Vasileios Simos, Lampros Lakkas, Panagiotis Filis, Dimitrios Peschos, Konstantinos Ioannis Tsamis","doi":"10.1016/j.physbeh.2025.114909","DOIUrl":"https://doi.org/10.1016/j.physbeh.2025.114909","url":null,"abstract":"<p><p>Cachexia is a complex multiorgan syndrome associated with various chronic diseases, characterized by anorexia and increased tissue wasting in the context of chronic inflammation. A specific form of this syndrome, known as cancer cachexia (CC), occurs alongside different types of tumors. The pathogenesis of CC is multifactorial. Inflammatory mediators and hormones released by both tumor and host cells have a relevant role in driving the peripheral catabolic process through several direct mechanisms. Accumulating evidence indicates that the central nervous system (CNS) plays an integral role in the pathogenesis of CC. The hypothalamus has emerged as a critical brain region that senses and amplifies peripheral stimuli, generating inappropriate neuronal signaling and leading to the dysregulation of energy homeostasis under cachexia conditions. Circulating cytokines may act in concert with hormones and neurotransmitters and perturb critical hypothalamic neurocircuits shifting their activity towards the anorexigenic pathway and increase of energy expenditure. This review discusses the mechanisms mediating the hypothalamic homeostatic imbalance in the context of anorexia and cachexia associated with cancer.</p>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":" ","pages":"114909"},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of infra-red thermography to study emotions of wild crested macaques (Macaca nigra) in their natural habitat.","authors":"Juliette M Berthier, Brandon C Wheeler, Indira N Qomariah, Dyah Perwitasari-Farajallah, Nicholas E Newton-Fisher","doi":"10.1016/j.physbeh.2025.114904","DOIUrl":"https://doi.org/10.1016/j.physbeh.2025.114904","url":null,"abstract":"<p><p>Infra-red thermography (IRT) has been validated across a range of taxa as a non-invasive method to quantify physiological changes (variation in skin temperature) that serve as a proxy for emotional arousal in humans and other animals. While its effectiveness has been demonstrated in captivity, its application in wild animals under natural conditions remains underexplored. This study validates IRT in wild crested macaques (Macaca nigra), observed in their natural habitat, to assess its potential for studying short-term emotions as proximate mechanisms of behavior of wild animals. Seventy-five playback experiments and predator model presentations were conducted on 14 adult females, exposing them to stimuli including affiliative grunts, contact calls, aggressive screams, alarm calls, and python models. The objectives were to: (1) evaluate whether environmental and physical factors, such as atmospheric conditions and camera-subject distance, impact thermal measurements; (2) determine whether facial skin temperature variations reliably indicate emotional arousal and valence in response to ecologically relevant stimuli; and (3) explore correlations between temperature changes and behavioral indicators of arousal, such as physical activity and self-directed behaviors. Results showed that: (1) environmental and physical factors did not significantly affect thermal measurements when following our protocol; (2) facial skin temperature changes reliably reflected the intensity of emotional arousal elicited by different stimuli; and (3) temperature variation was associated with behavioral indicators of arousal and anxiety. These findings establish IRT as a reliable tool for investigating emotion-driven skin temperature changes in wild primates, providing valuable insights into the role of short-term emotions in shaping behavior.</p>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":" ","pages":"114904"},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ' The Role of Ultrasonic Vocalizations in Rat Laryngological Investigations' [Physiology & Behavior volume 294 (2025) Start page 1 -End page 10 /Article Number 114887].","authors":"Adrianna C Shembel, Aaron M Johnson, Michelle R Ciucci, Charlie Lenell Lunaris, Robert A Morrison, Denis Michael Rudisch","doi":"10.1016/j.physbeh.2025.114907","DOIUrl":"https://doi.org/10.1016/j.physbeh.2025.114907","url":null,"abstract":"","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":" ","pages":"114907"},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary protein restriction in rats leads to a rapid within-session preference for protein","authors":"Giulia Chiacchierini ,&nbsp;Fabien Naneix ,&nbsp;John Apergis-Schoute ,&nbsp;James E McCutcheon","doi":"10.1016/j.physbeh.2025.114882","DOIUrl":"10.1016/j.physbeh.2025.114882","url":null,"abstract":"<div><div>Evolution has provided species with adaptive behavioural mechanisms that guarantee tight dietary protein regulation. However, an unsolved question is whether the well-established preference for protein-containing food manifested during states of protein restriction is innate or learned. Here, we tackled this problem by maintaining male rats on either a low-protein diet (4 % protein, protein-restricted) or a control diet (22 % protein, non-restricted) for 9–12 days, and then offered them two novel foods, a protein-containing solution (4 % casein) and a carbohydrate-containing solution (4 % maltodextrin) during a daily 60-minute free-choice test, repeated for 5 consecutive days. We assessed both the total and cumulative intake of each solution throughout each test, as well as the microstructure of licking behaviour as an index of the solutions’ palatability. In a second experiment, we exposed a different cohort of rats, before any behavioural test, to the same protein source (i.e., casein) that they would encounter during the free-choice tests, to assess whether familiarity with casein would drive subsequent casein intake even in non-restricted rats. We found that dietary protein restriction leads to a rapid preference (within 5 min of first exposure) for a casein-rich solution, and this preference is persistent over subsequent exposures. Increased palatability of protein during initial exposure correlated with protein preference in the restricted rats. Moreover, familiarity with casein did not lead to protein preference in non-restricted rats. This study demonstrates that, when in need of protein, protein preference is a rapid adaptation that requires minimal experience of protein.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114882"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of urinary chemosignals on mice behavior in the tube test","authors":"Kseniya Avimova,&nbsp;Dmitry Sandakov","doi":"10.1016/j.physbeh.2025.114903","DOIUrl":"10.1016/j.physbeh.2025.114903","url":null,"abstract":"<div><div>Many animal species form dominance hierarchies, and one of the ways of maintaining them is individual recognition. Mice recognize each other and individual social status via olfactory urinary signaling. We tested if familiarity with urine scent alters mice behavior when competing in the Tube test.</div><div>Subordinate mice, who were familiar with the scent of a dominant individual applied on their opponents, lose more than subordinates not familiar with the scent of the same dominant applied on their opponents. Moreover, these familiar with dominant's odor mice withdrew more often than the unfamiliar with dominant's odor mice.</div><div>The results obtained show that 1) mice use individual recognition during the competition in the Tube test, 2) like in other species, social hierarchy in mice can be maintained with the withdrawal of subordinates.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114903"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary exercise is a moderately effective mitigator of chronic social isolation stress in two female rodent models","authors":"Michael R. Jarcho ,&nbsp;Asavari Gowda ,&nbsp;Annamaria Walden ,&nbsp;Yessenia Chavez ,&nbsp;Alex Amidei ,&nbsp;Marigny C. Normann ,&nbsp;Oreoluwa I. Akinbo-Jacobs ,&nbsp;Dmitry Kovalev ,&nbsp;Jessica Linley ,&nbsp;Linnea Endsley ,&nbsp;Teva Crandall ,&nbsp;Angela J. Grippo","doi":"10.1016/j.physbeh.2025.114902","DOIUrl":"10.1016/j.physbeh.2025.114902","url":null,"abstract":"<div><div>Depression is a common mood disorders, particularly among women, and often with social stress precursors. Exercise, in addition to the known physical benefits, can have psychological benefits, potentially alleviating certain symptoms of stressors. This study investigated the impact of chronic social isolation stress in two female rodent models – mice and prairie voles. To assess the mitigating impact of exercise, paired and isolated animals were either provided 24-hour access to running wheels in their cages or remained sedentary. In mice, only animals that remained paired and had access to exercise wheels retained adaptive levels of active behaviors in the forced-swim test. However, either remaining paired or having access to a running wheel prevented increased corticosterone levels in mice. By contrast, in voles, either being paired or having access to a running wheel promoted adaptive levels of active behaviors in the forced-swim test. Similar to mice, either being paired or having access to a running wheel also prevented increased corticosterone levels in prairie voles. Body weight and adrenal:body mass ratios were not affected by either isolation or exercise in either species. Together these findings highlight the important differences between female rodents of different species in responses to chronic social stress. They also allude to differences between female and male rodent models. Lastly, these results indicate that for female rodents, exercise can provide certain mitigating effects against chronic social stress consequences.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114902"},"PeriodicalIF":2.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal stress and fluoxetine exposure in BTBR and B6 mice differentially affects autism-like behaviors in adult male and female offspring","authors":"Anna L. Arzuaga ,&nbsp;Pamela Teneqexhi ,&nbsp;Katelyn Amodeo ,&nbsp;John R. Larson ,&nbsp;Michael E. Ragozzino","doi":"10.1016/j.physbeh.2025.114891","DOIUrl":"10.1016/j.physbeh.2025.114891","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is characterized by significant heterogeneity in the variety and severity of symptoms. Prenatal stress and/or exposure to antidepressants may be major contributors to ASD heterogeneity. To date, the effects of prenatal stress or selective serotonin reuptake inhibitor exposure have been primarily examined in common laboratory rat and mouse strains as opposed to in rodent models of autism. The present experiments determined in the BTBR mouse model of autism whether restraint stress (30 min session every 2 days during G4 - G18) and/or exposure to the SSRI, fluoxetine (3 mg/kg during G8 - G18) affects repetitive motor behaviors, anxiety and/or behavioral flexibility in offspring at adulthood. Male and female BTBR mice exhibited elevated grooming behavior compared to that of C57BL/6 J (B6) mice. The prenatal manipulations did not affect grooming in male BTBR mice, but the combination increased rearing and jumping. Prenatal stress, fluoxetine and the combination significantly reduced self-grooming, while concomitantly increasing locomotion in female BTBR mice. These prenatal manipulations also increased rearing and jumping behavior in female BTBR mice. In B6 mice, the prenatal stress conditions increased grooming behavior. In addition, male BTBR mice exposed to prenatal stress and fluoxetine along with female BTBR mice prenatally exposed to fluoxetine were impaired on reversal learning. The prenatal manipulations had no effect on anxiety in either mouse strain. The pattern of results suggest that prenatal exposure to stress and/or a SSRI have long-term effects on autism-like behaviors and may contribute to the heterogeneity and co-morbidity observed in autism.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114891"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dopaminergic and opioidergic interactions in the nucleus accumbens in the suppression of pain affect: Exploring their impact on formalin-induced pain in rats","authors":"Hedie Abolghasemi ,&nbsp;Pariya Shahani ,&nbsp;Roghayeh Mozafari ,&nbsp;Nooshin Barikrow ,&nbsp;Batool Ghorbani Yekta ,&nbsp;Abbas Haghparast","doi":"10.1016/j.physbeh.2025.114894","DOIUrl":"10.1016/j.physbeh.2025.114894","url":null,"abstract":"<div><div>Recent studies suggest that the nucleus accumbens (NAc) may influence the brain's response to pain signals, indicating a role beyond motivation and reward. The study delved into how the D1-like dopamine receptors (D1Rs) and μ-opioid receptors (MOR) interact in the NAc region in the context of formalin-induced pain. Rats received intra-accumbal various doses of morphine as an MOR agonist (5, 10, 25, and 50 mmol/0.5μl) and different doses of SKF38393 as a selective D1Rs agonist (1.5, 3, 6, and 12 mmol/0.5μl) in separate experimental groups, respectively. In the second stage, animals received different doses of SCH23390 as a selective D1Rs antagonist (1.5, 3, 6, and 12 mmol) before an effective dose of SKF38393 (6 mmol) and morphine (10 mmol). The rats were then given naloxone as an MOR antagonist (1.5, 5, and 15 mmol) before being given an effective dose of SKF38393 (6 mmol). In the formalin test, 50 µl formalin (2.5 %) was subcutaneously injected into the rat's hind paw to induce pain behavioral responses. The main findings indicated that the opioidergic and dopaminergic systems in the NAc region interact to create analgesic effects. The injection of morphine and SKF38393 into the NAc resulted in pain-relieving impacts. However, SCH23390 decreased the antinociceptive impacts of SKF38393 and morphine. Similarly, naloxone reduced the analgesic effects of SKF38393. The interactions between D1Rs and MOR can lead to synergistic effects. Therefore, using D1Rs agonists along with morphine can enhance the antinociceptive effect of morphine while reducing its side effects.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114894"},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"URB597 modulates neuroplasticity, neuroinflammatory, and Nrf2/HO-1 signaling pathways in the hippocampus and prefrontal cortex of male and female rats in a stress-induced model of depression","authors":"Milica Jankovic,&nbsp;Natasa Spasojevic,&nbsp;Harisa Ferizovic,&nbsp;Bojana Stefanovic,&nbsp;Kristina Virijevic,&nbsp;Sladjana Dronjak","doi":"10.1016/j.physbeh.2025.114893","DOIUrl":"10.1016/j.physbeh.2025.114893","url":null,"abstract":"<div><div>Major depressive disorder is often associated with cognitive impairments, and neuroinflammation is considered a key contributor to the onset of depression. Pharmacological inhibition of fatty acid amide hydrolase (FAAH), which augments endocannabinoid signaling, has emerged as a promising approach to treating depression. The main purpose of this study is to asses the influence of FAAH inhibitor URB597 on inflammatory response and oxidative stress in chronic unpredictable stress (CUS)-induced depressive female and male rats and to explore the underlying molecular mechanisms. Chronically stressed animals showed long-term memory deficits, while URB597 improved memory only in stressed males. URB597 treatment enhanced levels of brain-derived neurotrophic factor (BDNF) in the hippocampus and mPFC of stressed female and male rats and increased phosphorylated calcium/calmodulin-dependent protein kinase II (pCaMKII) levels in the hippocampus and mPFC of CUS males. Additionally, increased phosphorylation of JAK2 and STAT3 in the hippocampus and mPFC of CUS male and female rats, was reduced following URB597 treatment. URB597 decreased the CUS-enhanced iNOS protein expression in the hippocampus and mPFC of both sexes. Furthermore, URB597 normalized CUS-induced reductions in Nrf2 and HO-1 levels in the mPFC of both sexes, with no changes in the hippocampus. Our findings suggest that URB597 may inhibit the CUS-induced neuroinflammatory response by suppressing the pro-inflammatory mediators and the activation of the JAK2/STAT3 signaling in the hippocampus and mPFC of both sexes. URB597 treatment contributed to synaptic plasticity in a sex-specific manner by upregulating brain CaMKII signaling in males. URB597 also exerts neuroprotective effects through region-specific antioxidant properties. These results have implications for sex-specific treatment strategies in stress-related neuropsychiatric disorders.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114893"},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forced wheel running pre-conditioning diminishes reward learning induced by methamphetamine: Involvement of orexin 1 receptor in the hippocampus","authors":"Mansoureh Ahmadpour ,&nbsp;Shaghayegh Modaberi ,&nbsp;Abbas Haghparast ,&nbsp;Rana Fayazmilani","doi":"10.1016/j.physbeh.2025.114892","DOIUrl":"10.1016/j.physbeh.2025.114892","url":null,"abstract":"<div><div>Methamphetamine (METH) is a highly addictive drug that leads to neurobehavioral changes related to the brain's reward circuit. Orexin and orexinergic receptors, found in crucial brain areas involved in reward processing, may play a significant role in reward mechanisms and addiction. Studies have shown that physical exercise can be an effective non-pharmacological approach to controlling drug use but limited research explores its role as pre-conditioning to prevent dependency on narcotics. In this study, 48 male Wistar rats were assigned into six groups: exercise training+saline (EX-SA), exercise training+METH 1mg/kg (EX-METH1), exercise training + METH 2 mg/kg (EX-METH2), control+saline (CON), control+METH 1 mg/kg (CON-METH1), control+METH 2 mg/kg (CON-METH2). The pre-conditioning groups underwent forced wheel-running training (five days a week, at 65 % Vmax) for eight weeks. Following pre-conditioning with exercise training, the METH groups received intraperitoneal (IP) METH injections using the conditioned place preference (CPP) model. After the post-test, the animals were dissected, and hippocampal tissue was collected to measure orexin receptor1 (OXR1) expression levels. The results showed that long-term, moderate-intensity forced exercise pre-conditioning prevented METH-induced CPP. However, CPP was observed only in the EX-METH2 group, receiving a double dose of the drug. Molecular analysis also revealed a significant increase in OXR1 expression in the hippocampus following METH injections, while physical exercise caused suppression in OXR1 increment. Seemingly, prior exercise influences this pathway and effectively prevents conditioning to METH, probably through OXR1, indicating an adaptation in the mesolimbic reward pathway that helps protect against METH addiction.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114892"},"PeriodicalIF":2.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}