Physiology & Behavior最新文献_第2页

Prenatal, but not neonatal, paracetamol exposure disrupts neuroendocrine regulation of stress and emotional behavior in adult male rats 产前，但不是新生儿，扑热息痛暴露破坏神经内分泌调节应激和情绪行为的成年雄性大鼠。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.physbeh.2026.115261

Arlet de Jesús Guzmán-Montemayor , Joshua Julian Sierra-Debernardi , Miriam Barradas-Moctezuma , Aleph A. Corona-Morales , Rebeca Toledo-Cárdenas , María Elena Hernández-Aguilar , Jorge Manzo , Deissy Herrera-Covarrubias , Genaro A. Coria-Avila

{"title":"Prenatal, but not neonatal, paracetamol exposure disrupts neuroendocrine regulation of stress and emotional behavior in adult male rats","authors":"Arlet de Jesús Guzmán-Montemayor , Joshua Julian Sierra-Debernardi , Miriam Barradas-Moctezuma , Aleph A. Corona-Morales , Rebeca Toledo-Cárdenas , María Elena Hernández-Aguilar , Jorge Manzo , Deissy Herrera-Covarrubias , Genaro A. Coria-Avila","doi":"10.1016/j.physbeh.2026.115261","DOIUrl":"10.1016/j.physbeh.2026.115261","url":null,"abstract":"<div><div>Paracetamol is a widely used analgesic and antipyretic, commonly administered during pregnancy and early postnatal life. Its mechanism of action involves inhibiting cyclooxygenase-2/3 (COX-2/3) enzymes, which play a critical role in normal brain development during the perinatal period. In this study, we investigated anxiety-like behavior, depression-like behavior, and corticosterone levels in adult male rats following either prenatal or neonatal paracetamol exposure. Pregnant dams received subcutaneous injections of paracetamol (60 mg/kg) or saline every 12 h from gestational day (GD) 16 to 20, while neonatal pups received the same treatment from postnatal day (PD) 1 to 5. At PD70, a subset of males was allowed to gain sexual experience, while others remained sexually naïve. Behavioral assessments were conducted on PD94 and PD95 using the elevated plus maze and the forced swim test, respectively. On PD107, males were exposed to bedding from estrous females as a social stimulus, and serum corticosterone levels were measured. Prenatal paracetamol exposure resulted in significantly reduced anxiety-like behavior and serum corticosterone, along with increased depression-like behavior in adulthood. In contrast, neonatal exposure produced no significant behavioral or hormonal alterations. These findings reveal differential sensitivity to paracetamol during distinct developmental windows, with prenatal exposure leading to long-lasting disruptions in emotional regulation and neuroendocrine stress responses. These effects may be mediated by COX inhibition or interference with neural circuits involved in stress regulation and motivational processing.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115261"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of food addiction on the treatment of eating disorders and obesity: A systematic review 食物成瘾对饮食失调和肥胖治疗的影响：一项系统综述。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.physbeh.2026.115248

Anna Laura Amato , Paola Gualtieri , Michela Cirillo , Giada La Placa , Giulia Frank , Rossella Cianci , Laura Di Renzo

{"title":"The impact of food addiction on the treatment of eating disorders and obesity: A systematic review","authors":"Anna Laura Amato , Paola Gualtieri , Michela Cirillo , Giada La Placa , Giulia Frank , Rossella Cianci , Laura Di Renzo","doi":"10.1016/j.physbeh.2026.115248","DOIUrl":"10.1016/j.physbeh.2026.115248","url":null,"abstract":"<div><div>Food addiction (FA) is a complex clinical condition that refers to addiction to highly palatable foods, represented by compulsive eating behavior and an incapacity to control food consumption, similar to other forms of addiction. This review examines the literature on FA and its impact on eating disorders and obesity. Using databases, such as PubMed, Cochrane Library and Google Scholar, recent studies were analyzed to show how FA may reduce treatment effectiveness, increase symptom severity, promote resistance to nutritional or pharmacological interventions, and elevate the risk of relapse.</div><div>The search strategy used the keywords 'food addiction', 'obesity', 'eating disorders', 'psychotherapy', and 'dietary therapy', limiting the reference period to studies published in the last five years. In reviewing the available articles, several nuances emerged that are fundamental to understanding FA, including neurobiological mechanisms, psychiatric comorbidities, environmental determinants, alterations in the gut microbiota, and the pervasive influence of ultra-processed foods. Taken together, the data indicate that FA not only intensifies symptom manifestation but also contributes to worse outcomes, with reduced compliance to standard treatments and an increased likelihood of relapse. These observations underscore the importance of recognizing FA as a critical component in clinical practice; neglecting its role and symptoms may compromise therapeutic efficacy. Further research is needed to establish integrative treatment models that include FA as a fundamental component of clinical patient care.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115248"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute aerobic exercise improves inhibitory control in individuals with test anxiety: evidence from event-related potentials 急性有氧运动改善考试焦虑个体的抑制控制：来自事件相关电位的证据。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.physbeh.2026.115250

Lingfeng Wu , Renlai Zhou

{"title":"Acute aerobic exercise improves inhibitory control in individuals with test anxiety: evidence from event-related potentials","authors":"Lingfeng Wu , Renlai Zhou","doi":"10.1016/j.physbeh.2026.115250","DOIUrl":"10.1016/j.physbeh.2026.115250","url":null,"abstract":"<div><div>It remains unclear whether acute aerobic exercise can effectively mitigate the inhibitory control deficits caused by test anxiety. This study investigated the effects of 30 min of moderate-intensity acute aerobic exercise on inhibitory control and related neural activities in individuals with high test anxiety. Forty participants were randomly assigned to an aerobic exercise group or a seated-reading control group, completing pre- and post-intervention assessments spaced one week apart. Statistical analyses using a series of repeated-measures ANOVAs revealed that, compared to the control group, the exercise group showed a significant reduction in self-reported test anxiety. Behaviorally, exercise led to significantly faster reaction times across both congruent and incongruent trials, coupled with a specific reduction in the Flanker conflict effect (RT difference between conditions), indicating enhanced interference control. Electrophysiologically, analysis of event-related potentials demonstrated that acute exercise modulated key cognitive components: N2 amplitude was significantly reduced and P3 amplitude was significantly enhanced in both task conditions following exercise, with no comparable changes in the control group. These findings suggest that acute aerobic exercise can enhance inhibitory control and alleviate test anxiety in university students.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115250"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mice from lines selectively bred for innately high activity levels have altered behavioral and energetic responses to repeated sleep deprivation 来自选择性培育的天生高活动水平系的小鼠对反复睡眠剥夺的行为和能量反应发生了改变。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.1016/j.physbeh.2026.115247

Chenkun Jiang, William Lampman, Juliana Base, Lucas Pineiro, Kai Chen, Edmundo Salvatier-Alvarez, Aubrey Qian, Zaina Barakat, Anthony Hernandez, Jordan Peters, Theodore Garland Jr

{"title":"Mice from lines selectively bred for innately high activity levels have altered behavioral and energetic responses to repeated sleep deprivation","authors":"Chenkun Jiang, William Lampman, Juliana Base, Lucas Pineiro, Kai Chen, Edmundo Salvatier-Alvarez, Aubrey Qian, Zaina Barakat, Anthony Hernandez, Jordan Peters, Theodore Garland Jr","doi":"10.1016/j.physbeh.2026.115247","DOIUrl":"10.1016/j.physbeh.2026.115247","url":null,"abstract":"<div><div>Sleep deprivation negatively impacts both physical and psychological health in both humans and animal models. Exercise, on the other hand, can have beneficial effects on various aspects of physical and mental health. However, little is known about the ways in which sleep deprivation and exercise may interact, especially for exceptionally high levels of exercise. We studied High Runner (HR) mice from a long-term artificial selection experiment to investigate how genetically high exercise level could impact the response to sleep deprivation. A total of 192 adult mice from four replicate HR and four non-selected Control lines (balanced for sex) completed six days of baseline wheel access, followed by three days with or without 6 h/day of total sleep deprivation (TSD) via gentle handling. As expected, HR mice ran farther and faster compared to Controls during days 1–6. TSD reduced the running distance and duration in mice from Control lines, while HR increased running speed and maintained distance (treatment × linetype interaction). TSD-induced changes in body mass differed between linetypes (treatment × linetype interaction): Controls tended to gain mass, whereas HRs lost mass. During the three days prior to TSD, HR mice consistently exhibited more active and fewer maintenance behaviors than Controls. TSD increased resting and decreased wheel activity in Controls but not HRs (treatment × linetype effects significant for both categories). These results demonstrate that genetically based high voluntary activity levels are associated with altered responses to TSD.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115247"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No effect of menopausal status on energy cost and substrate oxidation during walking in women with similar body composition and movement behaviors 在身体成分和运动行为相似的女性中，绝经状态对行走时的能量消耗和底物氧化没有影响。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.1016/j.physbeh.2026.115262

Camille Marcantei , Lore Metz , Ines Ramos , Bruno Pereira , Frederic Dutheil , Sarah De Saint Vincent , Martine Duclos , Laurie Isacco

{"title":"No effect of menopausal status on energy cost and substrate oxidation during walking in women with similar body composition and movement behaviors","authors":"Camille Marcantei , Lore Metz , Ines Ramos , Bruno Pereira , Frederic Dutheil , Sarah De Saint Vincent , Martine Duclos , Laurie Isacco","doi":"10.1016/j.physbeh.2026.115262","DOIUrl":"10.1016/j.physbeh.2026.115262","url":null,"abstract":"<div><div>The purpose of the study was to compare the energy metabolism responses at different walking speeds among pre, <em>peri</em> and postmenopausal women, with consideration for individual’s body composition characteristics and movement behaviors. Twenty-one premenopausal women (38.9 ± 5.0 years), twenty-two perimenopausal women (49.5 ± 3.8 years) and twenty-one postmenopausal women (55.4 ± 4.1 years) were included in the data analysis. Body composition (fat mass (FM) and fat-free mass (FFM)) was assessed by dual-energy X-ray absorptiometry and movement behaviors by accelerometry. Fasting blood samples were collected to determine pituitary and ovarian hormones concentrations. Energy cost of walking (gross and net C<sub>w</sub>), expressed both in absolute terms and relative to FFM, as well as substrate oxidation rates, was measured by indirect calorimetry during five 5-minute treadmill walking bouts at 2, 3, 4, 5, and 6 km.h<sup>-1</sup>, each separated by 3 min of seated rest. Results indicate that there were no significant differences in body composition, movement behaviors, and in C<sub>w</sub> and substrate oxidation rates during walking among the three groups. Negative correlations were found between moderate-to-vigorous physical activity and both gross and net C<sub>w</sub> relative to FFM at 5 km·h⁻¹ and 6 km·h⁻¹ (from <em>p</em> = 0.04 to <em>p</em> = 0.007). No correlations were found between estradiol concentration and C<sub>w</sub> or substrate oxidation rates, at any walking speed. Women experiencing the menopausal transition do not exhibit differences in energy metabolism during walking compared with pre and postmenopausal women when they have a similar body composition and movement behaviors.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115262"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosterone effects on aggression in a passerine species, the common waxbill Estrilda astrild 皮质酮对一种雀形目动物——普通蜡喙的攻击行为的影响。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1016/j.physbeh.2026.115264

Sandra Trigo , Beatriz C. Saldanha , Pedro Oliveira , Paulo A. Silva , Marta C. Soares

{"title":"Corticosterone effects on aggression in a passerine species, the common waxbill Estrilda astrild","authors":"Sandra Trigo , Beatriz C. Saldanha , Pedro Oliveira , Paulo A. Silva , Marta C. Soares","doi":"10.1016/j.physbeh.2026.115264","DOIUrl":"10.1016/j.physbeh.2026.115264","url":null,"abstract":"<div><div>Glucocorticoids mediate behavioral and physiological responses to environmental stressors, supporting individuals’ survival and fitness. Corticosterone, as the primary avian glucocorticoid, modulates these physiological responses. We focus on the common waxbill <em>Estrilda astrild</em>, a highly social and gregarious passerine that feeds and flocks together year-round, providing an excellent model to explore the impact of glucocorticoids on social behavior, especially in aggression. To investigate this, we conducted a correlational study in captive birds, examining baseline corticosterone plasma levels and three behavioral assays: 1) the tonic immobility test, a standard indicator of fear; 2) the mirror test, an assay to assess the reactive-proactive personality axis; and 3) food competition tests, which evaluate social behavior and aggression. Subsequently, we experimentally manipulated the common waxbill corticosterone levels by using exogenous high and low dosages of corticosterone to induce a short-term glucocorticoid challenge and evaluate its effects on behavior. Our results revealed that birds with higher baseline corticosterone plasma levels were less aggressive, but an acute increase in corticosterone levels increased aggression. Furthermore, corticosterone receptor antagonist reduced activity but did not affect feeding. These results suggest that corticosterone can influence aggression and activity in common waxbills, leading to a role in regulating social behavior in both sexes of this gregarious passerine species.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115264"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of social dominance on perineuronal nets in medial prefrontal cortex and basolateral amygdala 社会优势对内侧前额叶皮层和杏仁核基底外侧神经网络的影响。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-01-31 DOI: 10.1016/j.physbeh.2026.115246

Anna F. Radford, Conner J. Whitten, Ashley N. Wells, Mackenzie K. Hooker, Matthew A. Cooper

{"title":"Effects of social dominance on perineuronal nets in medial prefrontal cortex and basolateral amygdala","authors":"Anna F. Radford, Conner J. Whitten, Ashley N. Wells, Mackenzie K. Hooker, Matthew A. Cooper","doi":"10.1016/j.physbeh.2026.115246","DOIUrl":"10.1016/j.physbeh.2026.115246","url":null,"abstract":"<div><div>The development of dominance relationships generates experience-dependent plasticity in cortical circuits controlling social behavior and responses to stress. Perineuronal nets (PNN) are specialized extracellular structures that surround cortical neurons and contribute to experience-dependent neural plasticity. Using a Syrian hamster model, we investigated whether the development of dominance relationships altered the expression of PNNs in the infralimbic (IL) and prelimbic (PL) regions of the ventral medial prefrontal cortex, as well as the basolateral amygdala (BLA). We also tested whether PNN expression predicted agonistic behavior during the early or late phases of dominance interactions. Male and female hamsters were paired with same-sex partners and exposed to daily dominance interactions for two weeks. In Study 1, brains from male hamsters were collected for PNN staining 60 mins or 1–3 days following the final dominance interaction. We found that dominant males had more IL neurons surrounded by PNNs compared to subordinate males, and all hamsters showed greater PNN expression in caudal, compared to rostral, regions of the IL and PL. In Study 2, we included both males and females and collected brains 60 mins after the final dominance interaction. In Study 2, we found that subordinate females had more PL neurons surrounded by PNNs compared to dominants and social exposure controls. The rate of attacks during the late phase of dominance interactions predicted the number of PNN+ cells in the PL in dominant males, which is consistent with neural plasticity in PL neurons leading to elevated aggression in dominant males. Overall, the neural plasticity in the PL and IL induced by the formation of dominance relationships may contribute to sex differences in responses to social challenges.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115246"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.physbeh.2026.115260

Emmanouil Diakos , Georgios Theodorou , Nafsika Karakatsouli

{"title":"Learning-related performance of European seabass (Dicentrarchus labrax) and expression of c-fos and egr-1 immediate-early genes in the brain","authors":"Emmanouil Diakos , Georgios Theodorou , Nafsika Karakatsouli","doi":"10.1016/j.physbeh.2026.115260","DOIUrl":"10.1016/j.physbeh.2026.115260","url":null,"abstract":"<div><div>Fish learning abilities play a key role in optimizing husbandry and feeding strategies. This study examines spatial learning and associated neuronal gene expression in European seabass (<em>Dicentrarchus labrax</em>), a species widely farmed in the Mediterranean. Individuals were classified as learners (L), non-learners (NL), or non-attempters (NA) based on performance in a spatial task over 3- and 8-day learning periods. Approximately 10–16% of fish successfully learned the task, showing improved trial times and increased expression of immediate early genes (IEGs) <em>egr-1</em> and <em>c-fos</em> in the telencephalon and inferior lobe of the hypothalamus, regions linked to learning, memory, and reward processing. UL fish displayed partial neural activation but inconsistent behavioral success, likely influenced by motivation or stress, while NL fish showed behavioral apathy and lower gene expression. Prolonged training led to habituation and neural desensitization, whereas the shorter, 3-day learning better captured learning-related gene expression changes. These findings indicate that IEG expression is a reliable marker of learning-related brain activity but may also reflect stress responses. Thus, recognizing individual variability in cognitive performance and well-managed learning protocols can improve fish welfare and feeding efficiency in aquaculture.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115260"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apelin-13 induces lordosis behavior in estradiol-primed ovariectomized rats via the activation of multiple protein kinases in the ventromedial hypothalamus Apelin-13通过激活下丘脑腹内侧多种蛋白激酶诱导雌二醇诱导的去卵巢大鼠前凸行为。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-05-01 Epub Date: 2026-02-03 DOI: 10.1016/j.physbeh.2026.115249

Ailyn Luna-Hernández , Raymundo Domínguez-Ordóñez , Marcos García-Juárez , José Luis Encarnación Sánchez , José Luis Tlachi-López , James G. Pfaus , Oscar González-Flores

{"title":"Apelin-13 induces lordosis behavior in estradiol-primed ovariectomized rats via the activation of multiple protein kinases in the ventromedial hypothalamus","authors":"Ailyn Luna-Hernández , Raymundo Domínguez-Ordóñez , Marcos García-Juárez , José Luis Encarnación Sánchez , José Luis Tlachi-López , James G. Pfaus , Oscar González-Flores","doi":"10.1016/j.physbeh.2026.115249","DOIUrl":"10.1016/j.physbeh.2026.115249","url":null,"abstract":"<div><div>The present study aimed to determine whether apelin-13 facilitates lordosis behavior through the activation of specific hypothalamic kinases and to identify which signaling pathways mediate this response. Because lordosis is a well-established neuroendocrine indicator of female sexual receptivity, it served as an appropriate behavioral model to detect peptide-induced facilitation. Thus, we examined the role of protein kinase A (PKA), protein kinase C (PKC), mitogen activated protein kinase (MAPK), or Src kinase (Src), in the facilitation of lordosis behavior following bilateral intrahypothalamic injection of 0.75 μg of apelin-13 to ovariectomized-estradiol benzoate (OVX-EB) primed rats. Apelin-13 consistently induced lordosis at 30, 120, and 240 minutes post-infusion. To explore the role of these kinases, various inhibitors or their vehicles were administered bilaterally into the ventromedial hypothalamus (VMH) of OVX-EB-primed rats 30 min before the infusion of apelin-13. The inhibitors used were Rp-cAMPS for PKA, bisindolilmaleimide (BIS) for PKC, PD98059 for MAPK, and PP2 for Src. The VMH injection of Rp-cAMPS failed to reverse the facilitation of lordosis at the different times tested, while BIS or PP2 decreased the lordosis quotient (LQ) significantly only at 240 min without any statistical effect on the lordosis score (LS). However, PD98059 significantly reduced both the LQ and LS at 120 and 240 min. These data indicate that apelin-13 exerts its facilitatory effects on lordosis through MAPK, PKC, and/or Src, but not PKA pathways.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"308 ","pages":"Article 115249"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of fascin loss on animal behavior using a knockout mouse model 用敲除小鼠模型研究筋膜蛋白缺失对动物行为的影响。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.physbeh.2026.115243

Sarah Farooq , Angela Inglis , Falah Almohanna , Jennifer Thiam , Samiyah Al-Khaldi , Rayanah Barnawi , Hazem Ghebeh , Monther Al-Alwan

{"title":"Effect of fascin loss on animal behavior using a knockout mouse model","authors":"Sarah Farooq , Angela Inglis , Falah Almohanna , Jennifer Thiam , Samiyah Al-Khaldi , Rayanah Barnawi , Hazem Ghebeh , Monther Al-Alwan","doi":"10.1016/j.physbeh.2026.115243","DOIUrl":"10.1016/j.physbeh.2026.115243","url":null,"abstract":"<div><div>Fascin 1 is an actin-bundling protein with limited expression in normal tissues, such as the brain and spleen. Fascin knockout mice exhibit enlarged lateral ventricles and impaired neuronal extension in the posterior region of the anterior commissure. Despite these observations, the effect of fascin loss on animal behavior and cognitive function has not been previously assessed. In the present study, fascin knockout (fascin<sup>−/−</sup>) and wild-type (fascin<sup>+/+</sup>) female mice were compared on a number of standard behavioral tests, including open-field, object recognition, elevated plus maze, light–dark transition, sociability, and Morris water maze tests. Fascin<sup>-/-</sup> mice exhibited reduced locomotor activity during the open-field test and spent more time in the dark zone during the light–dark transition tests. Furthermore, fascin<sup>-/-</sup> mice showed comparable social interactions and exhibited altered early exploratory behavior during Morris water maze tests. This study concluded that whole-body fascin loss modestly affects animal behavior, particularly locomotor and exploratory activities. The whole-body knockout experimental findings highlight the regulatory role of fascin on these behavioral domains and emphasize the importance of considering these effects in future studies using this animal model.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"307 ","pages":"Article 115243"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0