Physiology & Behavior最新文献

{"title":"Differences in memory performance: The effects of sex and reproductive experience on object recognition memory in high- and low-yawning Sprague‒Dawley rats","authors":"Lilia Díaz ,&nbsp;Carmen Cortes ,&nbsp;Araceli Ugarte ,&nbsp;Angélica Trujillo ,&nbsp;Jose R Eguibar","doi":"10.1016/j.physbeh.2024.114713","DOIUrl":"10.1016/j.physbeh.2024.114713","url":null,"abstract":"<div><div>The novel object recognition (NOR) test is an efficient way to measure nonspatial memory in rodents. The NOR performance of female and male rats is sexually dimorphic because memory performance is better in the former than in the latter. In females, maternal experience enhances spatial memory. We used the NOR test to evaluate short- and long-term recognition memory in both sexes in the high- and low-yawning sublines of rats (HY and LY, respectively), which were generated via a strict inbreeding process from the Sprague‒Dawley (SD) strain for more than ninety generations. Additionally, we evaluated the effect of maternal experience using nulliparous, primiparous, biparous, and multiparous HY, LY and SD dams. Our results revealed that LY rats presented less thigmotaxis, with lower central square crosses and more vertical exploration in the open-field arena, suggesting that they experienced anxiety. Additionally, LY males performed significantly better than LY females in short- and long-term NOR memory, and LY males performed significantly better than SD rats did. Among females, two maternal experiences negatively affected short-term memory in the LY and HY sublines with respect to primiparous dams, and HY dams had better memory performance in the NOR test than did SD dams. Our findings suggest that the yawning sublines are suitable for studying the neurobiological basis of different memory processes under different endocrine conditions in highly inbred groups of rats.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity alters circadian and behavioral responses to constant light in male mice","authors":"Meredith E. Burns ,&nbsp;Fernanda Medeiros Contini ,&nbsp;Julie M. Michaud ,&nbsp;Caitlin T. Waring ,&nbsp;John C. Price ,&nbsp;Alexander T. McFarland ,&nbsp;Samantha G. Burke ,&nbsp;Cloey A. Murphy ,&nbsp;Grace E. Guindon ,&nbsp;Merideth K. Krevosky ,&nbsp;Joseph A. Seggio","doi":"10.1016/j.physbeh.2024.114711","DOIUrl":"10.1016/j.physbeh.2024.114711","url":null,"abstract":"<div><div>Exposure to artificial light during the night is known to promote disruption to the biological clock, which can lead to impaired mood and metabolism. Metabolic hormone secretion is modulated by the circadian pacemaker and recent research has shown that hormones such as insulin and leptin can also directly affect behavioral outcomes and the circadian clock. In turn, obesity itself is known to modulate the circadian rhythm and alter emotionality. This study investigated the behavioral and metabolic effects of constant light exposure in two models of obesity – a leptin null mutant (OB) and diet-induced obesity via high-fat diet. For both experiments, mice were placed into either a standard Light:Dark cycle (LD) or constant light (LL) and their circadian locomotor rhythms were continuously monitored. After 10 weeks of exposure to their respective lighting conditions, all mice were subjected to an open field assay to assess their explorative behaviors. Their metabolic hormone levels and inflammation levels were also measured. Behaviorally, exposure to constant light led to increased period lengthening and open field activity in the lean mice compared to both obesity models. Metabolically, LL led to increased cytokine levels and poorer metabolic outcomes in both lean and obese mice, sometimes exacerbating the metabolic issues in the obese mice, independent of weight gain. This study illustrates that LL can produce altered behavioral and physiological outcomes, even in lean mice. These results also indicate that obesity induced by different reasons can lead to shortened circadian rhythmicity and exploratory activity when exposed to chronic light.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detrimental effect of prenatal progesterone exposure on anxiety and depressive-like responses in adult male and female rat offspring: Role of plasma, hippocampal corticosterone and hippocampal progesterone receptors","authors":"Zlatina Nenchovska ,&nbsp;Milena Atanasova ,&nbsp;Tsveta Stoynova ,&nbsp;Gergana Toteva ,&nbsp;Jana Tchekalarova","doi":"10.1016/j.physbeh.2024.114712","DOIUrl":"10.1016/j.physbeh.2024.114712","url":null,"abstract":"<div><div>In clinical practice, the use of exogenous progesterone (Pro) is often required in assisted reproduction programs due to reduced levels of the hormone and the risk of miscarriage. Exposure to the hormone reduces anxiety in rodents, but the long-term effects of prenatal exposure in adult offspring are unknown. Therefore, the present study was designed to investigate the effect of prenatal Pro treatment on anxiety- and depression-like behavior and the effect on plasma, hippocampal corticosterone (CORT) and hippocampal progesterone receptor (PR) in young adult male and female rat offspring. The behavioral responses of offspring of both sexes were tested in the open field, and the elevated plus maze tests, and for depressive-like behavior in the sucrose preference test, the forced swimming test and the splash test. CORT levels and PR expression were measured by ELISA. The results indicate that prenatal Pro exposure at low and high doses (10 and 50 mg kg^-1, s.c. during G0-G10) induces anxiogenic and depressive-like effects compared to vehicle-treated controls, which are associated with high plasma and hippocampal CORT levels and upregulated hippocampal PR in male and female adult offspring. Our results demonstrate that prenatal Pro exposure has detrimental effects on the emotional status of male and female adult offspring, which may be associated with long-term changes in hormonal homeostasis.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mounting exhibited between cows is not associated with sexual motivation","authors":"Satoru Suzuki ,&nbsp;Hideki Ogasawara ,&nbsp;Reina Fujimoto ,&nbsp;Yasushi Kiyokawa ,&nbsp;Yukari Takeuchi","doi":"10.1016/j.physbeh.2024.114710","DOIUrl":"10.1016/j.physbeh.2024.114710","url":null,"abstract":"<div><div>Females of various species exhibit mounting behavior toward other mature females, i.e., female–female (f–f) mounting. Cows exhibit f–f mounting, which is commonly considered a sexual behavior based on a few similarities with male sexual mounting. Here, we hypothesized that the degree of f–f mounting exhibited by cows in estrus would increase when they are sexually motivated by sexually relevant stimuli. To test this hypothesis, two groups of four cows each were prepared. First, estrus was induced in one of the cows in each group by injecting estradiol in the presence of a non-sexually active male steer as a stimulus animal (<em>steer</em>-stimulus condition), and all f–f mounts were recorded. Estrus induction was repeated until induced in all cows. We then changed the stimulus animal from the steer to a sexually active bull (<em>bull</em>-stimulus condition), and the estrus induction procedures were repeated as before. We confirmed that estrus was induced successfully in cows injected with estradiol and that they were sexually motivated by switching the stimulus animal from steer to bull, as they spent relatively more time with the stimulus animal in the <em>bull</em>-stimulus than in the <em>steer</em>-stimulus condition and when not in estrus. However, f–f mounting frequency in the <em>bull</em>-stimulus condition showed no significant difference to that in the <em>steer</em>-stimulus condition. We observed that six of the eight subjects exhibited f–f mounting when not in estrus, which accounted for 44.6 % of f–f mounting we observed (n = 668). These findings suggest that f–f mounting in cows is not associated with sexual motivation.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the moderating effects of anger expression style on the association between facets of trait anger and cardiovascular responses to acute psychological stress","authors":"Adam O'Riordan ,&nbsp;Aisling M. Costello","doi":"10.1016/j.physbeh.2024.114709","DOIUrl":"10.1016/j.physbeh.2024.114709","url":null,"abstract":"<div><h3>Objective</h3><div>The current study aims to (1) examine the association between measures of trait anger (i.e., anger temperament and anger reaction) and cardiovascular reactivity to acute psychological stress, and (2) to identify if anger expression styles moderate the association between trait anger and cardiovascular reactivity.</div></div><div><h3>Methods</h3><div>A sample of 669 participants completed a standardized cardiovascular reactivity protocol consisting of resting baseline and stressor phase (mental arithmetic and Stroop), with systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) monitored throughout. Participants also completed measures of trait anger including anger temperament and anger reaction, as well as measures assessing anger expression styles including anger-in, anger-out and anger control.</div></div><div><h3>Results</h3><div>Anger temperament was significantly associated with blunted cardiovascular reactivity, as well as increased levels of subjective stress. Moreover, the association between anger temperament and cardiovascular reactivity was significantly moderated by anger-in, with associations observed only amongst those who reported an increased tendency to suppress their anger. The association between anger reaction and cardiovascular reactivity was moderated by both anger-out and anger control.</div></div><div><h3>Conclusion</h3><div>While blunted cardiovascular responses may be a mechanism linking facets of trait anger to adverse health outcomes, the current findings accentuate the importance of considering expression styles when examining the association between anger experience and cardiovascular reactivity.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological costs of warning: Defensive hissing increases metabolic rate and evaporative water loss in a venomous snake","authors":"Nicolas Van Zele ,&nbsp;Thomas Nicot ,&nbsp;Thierry Lengagne ,&nbsp;Rémi Ksas ,&nbsp;Olivier Lourdais","doi":"10.1016/j.physbeh.2024.114708","DOIUrl":"10.1016/j.physbeh.2024.114708","url":null,"abstract":"<div><div>To minimize predation risk and the cost of confronting predators, prey have developed a range of defensive strategies and warning signals. Although advantageous, defensive warnings may also induce physiological and energy costs to the emitter. Ventilatory sounds (hissing) are the most distributed warning sound in vertebrates. Because they involve the respiratory apparatus, defensive hissing may substantially increase evaporative water loss. Herein, we examined the determinants of hissing as well as its physiological costs in a medium-sized venomous snake, the long-nosed viper (<em>Vipera ammodytes</em>). We first used a neutral arena and applied standardized stimulation to measure the occurrence and acoustic characteristics of warning hissing. Then, we used open-flow respirometry to quantify changes in respiratory gas exchanges (oxygen consumption and evaporative water loss) during defensive responses. We demonstrated that males are more likely to engage in sound warnings when stimulated. Expirations generated the strongest signals compared to inspiration but did not differ between sexes. We found that defensive hissing dramatically increased average metabolic rate and evaporative water loss during the 10-minute stimulation period, and this effect was more pronounced in males. Metabolic rates and evaporative water loss were closely related to the duration of hissing. Overall, our results indicate that respiratory-based warning sounds induce significant physiological costs and may alter water balance. The higher responsiveness in males than females likely reflects sexually selective pressure (higher mobility for mate acquisition) and enhanced risk exposure.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of food stimuli presentation on restrained eater's food choice: An ERP study","authors":"Yong Liu ,&nbsp;Xuemeng Zhang ,&nbsp;Yazhi Pang ,&nbsp;Jia Zhao ,&nbsp;Jinfeng Han ,&nbsp;Yuanluo Jing ,&nbsp;Hong Chen","doi":"10.1016/j.physbeh.2024.114704","DOIUrl":"10.1016/j.physbeh.2024.114704","url":null,"abstract":"<div><div>Restrained eaters are individuals who consciously follow a limited food intake diet to lose or maintain body weight. With the rising numbers of obesity cases, retrained eating has became more prevalent as more people adopt it to cope with obesity. The dual conflict theory states that restrained eaters often encounter conflicting choices of food pleasure and weight management. The present study investigated the difference in food choice regarding different presentations of the weight management goal. The study hypothesized difference in successful and unsuccessful restrained eaters’ food choice when presented with the conflicting food/weight maintenance stimuli. A total of 49 college students participated in the study and the N2, P3 and LPP event-related potentials (ERPs) were investigated during a food choice task. Results showed that the reaction time in unsuccessful restrained eaters (UREs) were greater than successful restrained eaters (SREs). The ERP results showed that SREs exhibited smaller N2 and greater P3 amplitudes than UREs, however, we did not find a difference in LPP amplitudes between the two groups. The findings suggest that the UREs demonstrated greater sensitivity and smaller inhibition to food cues, while we do not have supports for a difference in motivational and emotional salience. This is the first study that investigated the food choice of SREs and UREs when faced with different presentations of conflicting goals, which enriches the theoretical model and provides neural correlates evidence for future studies.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-induced overeating behaviors explained from a (transitory) relief-learning perspective","authors":"Silvia Papalini","doi":"10.1016/j.physbeh.2024.114707","DOIUrl":"10.1016/j.physbeh.2024.114707","url":null,"abstract":"<div><div>People use various behaviors to cope with stressful events. These behaviors are mostly adaptive, as they allow a successful release of stress without impacting other aspects of life: How nice is it to have a break with a few spoons of that favorite ice cream during a hectic working day? However, when excessive consumption of high-sugar/salt ultra-processed food becomes the gateway to find relief from stress, eating loses this adaptive function and may escalate to binge eating, lead to obesity, and other medical conditions linked to overweight.</div><div>Several etiological models attempt to explain stress-induced eating and excessive overeating behaviors characterizing these clinical conditions. The popular Emotional Eating Theory proposes that stress-related (over-)eating, a major predictor of obesity and diagnosed binge eating disorders, develops based on negative reinforcement learning since food consumption regulates the negative affective state associated with stressful circumstances. Differently, the prominent Incentive Sensitization Theory explains overeating, binge eating disorders (including bulimia), and obesity in terms of excessive amplification of reward ‘wanting’, which is thought to emerge from overexposure to obesogenic (food)cues. The several studies oriented by these theories have paved the way to better understand stress-related (over-)eating and its clinical excesses. However, a deep mechanistic understanding of how and why stress-induced (over-)eating can <em>escalate</em> till clinical forms of overeating remain elusive. A well-funded connection of the mechanisms proposed by the Emotional Eating Theory and the Incentive Sensitization Theory might address this etiological open question. To avoid erroneous arguments, it is however essential to first address the internal theoretical and methodological shortcomings of each theory and connected studies. These shortcomings stem from conceptual fallacies and poorly implemented designs, which might partially explain the ‘high variability and low replicability’ problem of empirical findings. Next, the formulation of a new integrative model could provide fresh insight into the deep learning and biological mechanisms of this escalation. A successful formalization of this model could then create the much-needed impact in clinical and preventive research since excessive overeating is a behavior hard to change once established.</div><div>In this opinion paper, I propose to apply recent insights we gathered on the role of relief from the field of safety learning to stress (over-)eating. I will present a new relief-based model that, as a starting point, has the potential to connect the Emotional Eating Theory with the Incentive Sensitization Theory, setting the base for more integrative science.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A performance-based mental workload identification method for special vehicle crews","authors":"Mingyang Guo,&nbsp;Peiyan Duan,&nbsp;Xiaoping Jin,&nbsp;Qingyang Huang,&nbsp;Yuning Wei","doi":"10.1016/j.physbeh.2024.114706","DOIUrl":"10.1016/j.physbeh.2024.114706","url":null,"abstract":"<div><div>Detecting the mental workload state of armored vehicle crews is of great significance for monitoring the driving state of the crew and improving comprehensive combat effectiveness. In this manuscript, we propose a performance-based mental workload identification method and carry out experimental validation to improve the accuracy of crew mental workload identification and realize the effective classification of mental workload. Based on the virtual simulation system of the special vehicle crew task, this manuscript selects 20 subjects for the mental workload experiment of special vehicle crews. The experiment collected NASA-TLX scale, EEG, eye-tracking data, and performance data. The results show that the mental workload of the crews fluctuates in the segmented tasks of complex operations in typical scenes of special vehicles. The method of determining mental workload using NASA-TLX generates label noise in classification, which is not suitable for special vehicle tasks. Performance-based mental workload identification method is able to recognize fluctuations in the crew's mental workload during segmented tasks. Performance-based and NASA-TXL-based methods were classified using linear discriminant analysis. The results show that the accuracy of the method based on performance is improved by 15.72 %. This manuscript found the NASA-TXL scale is not suitable for the complex tasks of special vehicles, and proposed a performance-based identification method that can help to categorize the mental workload states of special vehicle crews.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet","authors":"Tomoyuki Sasaki ,&nbsp;Mariko Sugiyama ,&nbsp;Mitsuhiro Kuno ,&nbsp;Takashi Miyata ,&nbsp;Tomoko Kobayashi ,&nbsp;Yoshinori Yasuda ,&nbsp;Takeshi Onoue ,&nbsp;Hiroshi Takagi ,&nbsp;Daisuke Hagiwara ,&nbsp;Shintaro Iwama ,&nbsp;Hidetaka Suga ,&nbsp;Ryoichi Banno ,&nbsp;Hiroshi Arima","doi":"10.1016/j.physbeh.2024.114703","DOIUrl":"10.1016/j.physbeh.2024.114703","url":null,"abstract":"<div><div>A high-fat diet (HFD) causes inflammation with an increase in microglial activity in the hypothalamic arcuate nucleus (ARC) and ventral tegmental area (VTA), resulting in insulin resistance in both regions. This leads to a deterioration in glucose and energy metabolism. The effect of voluntary exercise on HFD-induced inflammation in the central nervous system (CNS) remains unclear. To clarify the effects of voluntary exercise on the CNS, 8-week-old male C57BL6 mice were fed a chow diet (CHD) or HFD for 4 weeks; each group was further divided into running exercise (EX+) on a wheel and no exercise (EX-) groups. The expression of the inflammatory cytokine, tumor necrosis factor alpha (TNFα), in the ARC and VTA was significantly increased in the HFD/EX- group, with an increase of microglial activity noted, compared to the CHD/EX- group. The expression of TNFα was significantly suppressed, with a decrease of microglial activity, in the HFD/EX+ compared to HFD/EX- group. Insulin resistance in the ARC and VTA was improved with the suppression of TNFα expression. The HFD/EX- group showed significant weight gain and impaired glucose metabolism compared to the CHD/EX- group. The HFD/EX+ group showed an improvement in glucose and energy metabolism compared to the HFD/EX- group. In addition, voluntary wheel running suppressed HFD-induced inflammation in the ARC, with a decrease in microglial activity observed independently of weight changes. Our data suggest that voluntary exercise prevents obesity and improves glucose metabolism by suppressing inflammation in the ARC and VTA under HFD conditions.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}