Physiology & Behavior最新文献_第3页

Inspiratory muscle glycemic threshold in COPD: functional and clinical associations in incremental testing COPD患者的吸气肌血糖阈值：增量检测的功能和临床关联。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-10 DOI: 10.1016/j.physbeh.2025.114991

Wasly S. Silva , Felipe J. Aidar , Georgian Badicu , Juliana D. Andrade , Patricia F. Sá , José B. Neto , Luca Paolo Ardigò , Jefferson Petto

{"title":"Inspiratory muscle glycemic threshold in COPD: functional and clinical associations in incremental testing","authors":"Wasly S. Silva , Felipe J. Aidar , Georgian Badicu , Juliana D. Andrade , Patricia F. Sá , José B. Neto , Luca Paolo Ardigò , Jefferson Petto","doi":"10.1016/j.physbeh.2025.114991","DOIUrl":"10.1016/j.physbeh.2025.114991","url":null,"abstract":"<div><div>It is known that COPD is multifactorial and reduces the function of several body systems; however, its impact on inspiratory muscle metabolism and its possible clinical implications and for inspiratory muscle training are still unclear. Furthermore, the use of the glycemic threshold (GT) of inspiratory muscles as a viable and clinically useful metabolic measure in COPD is not yet addressed in the literature. This study aimed to verify whether there is an association between the GT of inspiratory muscles with Borg, functional capacity (FC) and cardiovascular autonomic balance in COPD. Included patients with COPD under outpatient follow-up and evaluated them using incremental inspiratory muscle testing (IIMT), six-minute walk test (6MWT), and heart rate variability (HRV). The GT of inspiratory muscles was strongly associated with Borg in the IIMT. The strength endurance and aerobic capacity of inspiratory muscles demonstrated by the exhaustion point (EP) and delta GT/EP showed a strong inverse correlation with the cardiovascular autonomic balance demonstrated by the LF/HF ratio. Delta GT/EP also showed an inverse correlation with dyspnea by the mMRC scale and with the final Borg in the 6MWT. The study concluded that the GT and EP of the inspiratory muscles are strongly associated with Borg in individuals with COPD. Furthermore, the aerobic capacity of the inspiratory muscles was strongly associated with dyspnea on exertion and cardiovascular autonomic balance.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114991"},"PeriodicalIF":2.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contributions of taste cues to ethanol responses in female and male rats 味觉线索对雌雄大鼠乙醇反应的影响

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-09 DOI: 10.1016/j.physbeh.2025.114988

Tiffany Ho, Solena R. Hessel, Yada Treesukosol

{"title":"The contributions of taste cues to ethanol responses in female and male rats","authors":"Tiffany Ho, Solena R. Hessel, Yada Treesukosol","doi":"10.1016/j.physbeh.2025.114988","DOIUrl":"10.1016/j.physbeh.2025.114988","url":null,"abstract":"<div><div>Bitter-tasting stimuli, like ethanol (EtOH), are innately avoided yet variability in orosensory-driven behaviors may contribute to differences in ethanol intake. Experiment 1 was designed to test the hypothesis that there are sex differences in the taste qualities of ethanol. Female and male rats were presented 5 or 10 % EtOH followed by administration (i.p.) of LiCl to induce visceral malaise, or saline as a control. Generalization of the conditioned avoidance was assessed in a brief-access taste test (10-s trials; 30-min session) in which water, 0.03 and 0.3 M sucrose (“sweet”), 0.03 and 0.3 mM quinine (“bitter”) and sucrose-quinine mixtures were presented in randomized blocks without replacement. Conditioned avoidance of ethanol generalized to sucrose and sucrose-quinine mixtures. In experiment 2, unconditioned lick responses to an array of ethanol concentrations (1–32 %) were measured in rats following administration (i.p.) of saline, 0.1 or 1.0 mg/kg naltrexone, an opioid receptor antagonist. Compared to saline, naltrexone administration lowered trials initiated for both sexes, but decreased responses to 32 % ethanol only for males. Together these findings indicate the oral qualitative profile of ethanol is comparable and the sucrose-like component is most salient in both sexes. Opioidergic signaling that drives the appetitive components of behavior towards ethanol is similar for females and males but differs for some components of consummatory behavior. Thus, sex differences in responses to ethanol do not appear to be primarily driven by variability in qualitative components of ethanol that contributes to consummatory aspects of ingestive behavior, but more likely by reward-related signaling.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114988"},"PeriodicalIF":2.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of adolescent morphine exposure on brain stimulation reward sensitivity and dopamine neuron excitability 青少年吗啡暴露对脑刺激、奖励敏感性和多巴胺神经元兴奋性的影响。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-07 DOI: 10.1016/j.physbeh.2025.114987

Rachel M Donka , Maxine K Loh , Sean Schrank , Joshua P Sevigny , Sema M Patel , Deaglan A McAndrew , Dennis R Sparta , Jamie D Roitman

{"title":"Effects of adolescent morphine exposure on brain stimulation reward sensitivity and dopamine neuron excitability","authors":"Rachel M Donka , Maxine K Loh , Sean Schrank , Joshua P Sevigny , Sema M Patel , Deaglan A McAndrew , Dennis R Sparta , Jamie D Roitman","doi":"10.1016/j.physbeh.2025.114987","DOIUrl":"10.1016/j.physbeh.2025.114987","url":null,"abstract":"<div><div>Adolescent substance abuse drives lasting changes in reward processing and decision making. To determine the effects of opioid treatment and withdrawal on reward sensitivity during adolescence, we used a rate-frequency (RF) intracranial self-stimulation (ICSS) paradigm in adolescent rats. On PD28, rats were implanted with stimulating electrodes in the medial forebrain bundle at the level of the lateral hypothalamus and trained twice-daily to perform a variant RF ICSS task tailored for adolescents. Morphine (5 mg/kg) or saline (0.5 ml/kg) was injected daily prior to the AM ICSS session from PD45–51 and we continued to perform sessions through PD60 to measure withdrawal. Rats were then trained on a standard adult RF ICSS task. All animals were tested from PD90–96 while undergoing daily morphine administration (10mg/kg) and for an additional 9 days of withdrawal. In adolescent controls, reward sensitivity was stable across baseline, injection, and post-injection sessions. Adolescent morphine administration resulted in a significant increase in reward sensitivity relative to controls followed by a reduction lasting for the entire 9-day withdrawal period. Re-exposure to morphine in adulthood resulted in a greater increase in sensitivity during administration and a more profound suppression in withdrawal relative to those that had not been exposed to morphine in adolescence. In a separate group of animals, withdrawal from adolescent morphine treatment resulted in reduced electrophysiological excitability of ventral tegmental area dopamine neurons that may contribute to lasting alterations in reward sensitivity. Such alterations following adolescent morphine exposure may drive susceptibility to maladaptive behaviors in adulthood.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114987"},"PeriodicalIF":2.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different behavioral expression of adolescent male and female rats in Hole-Board evaluated through quantitative and T-pattern analysis 通过定量分析和t型分析，评价青春期雌雄大鼠在Hole-Board中的不同行为表达

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-06 DOI: 10.1016/j.physbeh.2025.114985

Maurizio Casarrubea , Daniel Cassar , Zachary Busuttil , Stefania Aiello , Giuseppe Crescimanno , Giuseppe Di Giovanni

{"title":"Different behavioral expression of adolescent male and female rats in Hole-Board evaluated through quantitative and T-pattern analysis","authors":"Maurizio Casarrubea , Daniel Cassar , Zachary Busuttil , Stefania Aiello , Giuseppe Crescimanno , Giuseppe Di Giovanni","doi":"10.1016/j.physbeh.2025.114985","DOIUrl":"10.1016/j.physbeh.2025.114985","url":null,"abstract":"<div><div>Studying the behavioral differences between male and female adolescent rats is of paramount importance for gaining a deeper understanding of how sex influences critical biological processes such as stress responses or susceptibility to psychiatric disorders. The present study aimed at comparing the behavior of adolescent male and female rats (post-natal day P30) tested in the Hole-Board paradigm, with a particular emphasis on the temporal organization and anxiety-related behaviors. Our analysis revealed a peculiar lack of significant findings in quantitative measures (e.g., mean occurrences and durations); on the contrary, highly significant sex-based differences concerning the temporal organization of behavior and the overall behavioral organization were observed. Our results suggest that adolescents female exhibited behaviors less constrained by the anxiety-related patterns observed in their male counterparts. These findings underscore the crucial role of adolescence in shaping key developmental dynamics, such as motivation, exploration, and anxiety regulation, thereby contributing to a deeper understanding of how these processes evolve differently between the sexes during this critical period of development.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114985"},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychophysiological and emotional antecedents of on-sight climbing performance with alterations in the style of ascent 随著攀爬方式的改变，现场攀爬表现的心理、生理及情绪前因。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-06 DOI: 10.1016/j.physbeh.2025.114986

David Giles , Kevin Mangan , Nick Draper

{"title":"Psychophysiological and emotional antecedents of on-sight climbing performance with alterations in the style of ascent","authors":"David Giles , Kevin Mangan , Nick Draper","doi":"10.1016/j.physbeh.2025.114986","DOIUrl":"10.1016/j.physbeh.2025.114986","url":null,"abstract":"<div><h3>Background</h3><div>Lead climbing has been speculated to be a significant source of stress for rock climbers, presumably due to the potential for and perceived consequences of a lead fall. The aim of this study was to investigate psychophysiological, and emotional and performance differences with a randomised series of on-sight climbs with different ascent styles. Cardiovascular reactivity, a repeated measures design and performance assessments were used to build upon previous research.</div></div><div><h3>Methods</h3><div>32 intermediate climbers attempted three separate routes, on-sight, identical in difficulty, but utilizing different safety protocols: top-rope, lead or lead with run-out. Measurements of climbing performance (technique, tactics, etc.), psychophysiological (heart rate, cardiovascular reactivity, cortisol, etc.) and psychometric (somatic and cognitive anxiety, self-confidence) variables were taken pre- and post-receiving the task instructions; and before, during and after climbing for each ascent.</div></div><div><h3>Results</h3><div>Versus top-rope, lead and run-out ascents were characterised by (a) reduced performance quality (less fluent movement and increased geometric entropy (<em>p <</em> 0.005)); (b) significantly increased cognitive anxiety (<em>p =</em> 0.002) in both lead ascents and reduced self-confidence (<em>p =</em> 0.001), and greater somatic anxiety specifically in the run-out ascent (<em>p =</em> 0.011); and (c) no significant differences in salivary cortisol or pre-climb heart rate from baseline.</div></div><div><h3>Conclusion</h3><div>The results suggested that an increased likelihood of a climber falling was likely to be evaluated as threatening, elicit a negative emotional response and disrupt performance. Interventions addressing lead climbing anxiety should focus on reducing cognitive anxiety and improving self-confidence in order to reduce deterioration in performance occurring in intermediate climbers and improve enjoyment.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114986"},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal and spatial variability of dynamic microstate brain network based on event-related potential analysis in underwater target recognition task 水下目标识别任务中基于事件相关电位分析的动态微状态脑网络时空变异性

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-05 DOI: 10.1016/j.physbeh.2025.114971

Jiaqi Zhang , Zhangsong Shi , Huihui Xu , Ning Zhang , Junfeng Gao

{"title":"Temporal and spatial variability of dynamic microstate brain network based on event-related potential analysis in underwater target recognition task","authors":"Jiaqi Zhang , Zhangsong Shi , Huihui Xu , Ning Zhang , Junfeng Gao","doi":"10.1016/j.physbeh.2025.114971","DOIUrl":"10.1016/j.physbeh.2025.114971","url":null,"abstract":"<div><div>Underwater target detection is closely related to ocean research, underwater navigation, and marine fisheries. However, due to the interference of underwater environment, rapid recognition of underwater targets is still a difficult task. This study proposes an underwater target recognition system based on dynamic brain networks to address this issue. A dynamic brain network accurately represents a brain functional network by reflecting the state transitions over time. This study proposed a method combining the Event-Related Potential (ERP) analysis, microstates, and dynamic brain networks to investigate the spatiotemporal variability of the brain during underwater target recognition tasks. The electroencephalogram (EEG) data from 45 subjects were analyzed, and the overall change matrix of the dynamic brain network as a feature. The method achieved an average classification accuracy of 96.19 % across all the subjects. This approach demonstrated the efficacy of constructing dynamic brain network features based on the ERP microstates to identify the EEG signals across various tasks. Furthermore, it could offer new insights for the development of the underwater target recognition technology in the future.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114971"},"PeriodicalIF":2.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of slow-paced breathing and humming breathing on heart rate variability and affect: a pilot investigation 慢节奏呼吸和嗡嗡声呼吸对心率变异性和影响的影响：一项试点调查

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-05 DOI: 10.1016/j.physbeh.2025.114972

Minjung Woo , Teri Kim

{"title":"Effects of slow-paced breathing and humming breathing on heart rate variability and affect: a pilot investigation","authors":"Minjung Woo , Teri Kim","doi":"10.1016/j.physbeh.2025.114972","DOIUrl":"10.1016/j.physbeh.2025.114972","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effects of slow-paced breathing (SPB) and humming breathing on heart rate variability (HRV) and affect.</div></div><div><h3>Methods</h3><div>The study included 16 healthy adults. HRV was measured for five min under three conditions: rest, SPB (5-second inhale, 5 s exhale; administered using the EliteHRV application), and humming breathing (Bhramari Pranayama). The Visual Analogue Scale (VAS) assessed anxiety, stress, relaxation, and confidence across baseline, rest, SPB, and humming breathing conditions.</div></div><div><h3>Results</h3><div>Both SPB and humming breathing significantly increased HRV, with higher Standard Deviation of all Normal-to-Normal intervals (SDNN), Total Power (TP), and Low Frequency (LF) values than those in the rest condition. The VAS scores indicated higher relaxation levels during rest, SPB, and humming breathing than at baseline. No significant differences were observed between SPB and humming breathing in HRV or VAS measures.</div></div><div><h3>Conclusion</h3><div>These findings suggest that humming breathing is a viable alternative to SPB for enhancing HRV and autonomic regulation, without requiring specialized equipment or feedback.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114972"},"PeriodicalIF":2.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic deletion of microRNA-34 unmasks cardiac vulnerability to psychosocial stress in male mice microRNA-34基因缺失揭示了雄性小鼠心脏对社会心理应激的易感性。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-04 DOI: 10.1016/j.physbeh.2025.114984

Donald Ielpo , Illari Salvatori , Elena Fiori , Margherita Barbetti , Rossella Ventura , Luca Carnevali , Cristiana Valle , Alberto Ferri , Diego Andolina , Luisa Lo Iacono

{"title":"Genetic deletion of microRNA-34 unmasks cardiac vulnerability to psychosocial stress in male mice","authors":"Donald Ielpo , Illari Salvatori , Elena Fiori , Margherita Barbetti , Rossella Ventura , Luca Carnevali , Cristiana Valle , Alberto Ferri , Diego Andolina , Luisa Lo Iacono","doi":"10.1016/j.physbeh.2025.114984","DOIUrl":"10.1016/j.physbeh.2025.114984","url":null,"abstract":"<div><div>Exposure to chronic psychosocial stress is a major risk for cardiovascular disease. While the cardiovascular response to acute psychological stress is well known, the mechanisms underlying the risk to develop cardiovascular consequences in response to chronic stress exposure are poorly understood. The family of microRNA-34 (miR-34 s) is widely investigated for its role in cardiovascular dysfunctions, and recently miR-34 s were found involved in the brain adaptation to chronic stress. Here we investigated whether the miR-34 s contribute to psychosocial stress-induced cardiac vulnerability. We exploited a genetic mouse model to test the impact of chronic psychosocial stress on cardiac fibrosis and investigated mitochondrial dysfunction as a potential contributing factor in the presence or absence of miR-34 s. We found that in male mice lacking the miR-34 s the chronic stress exposure altered the behavioral adaptation to social defeat, increased the amount of cardiac fibrosis, reduced mitochondrial performance and altered the expression of apoptosis modulators in the myocardium. Our results revealed that the deletion of miR-34 s enhances cardiac vulnerability to psychosocial stress, suggesting a protective role of miR-34 s in the maintenance of cardiac homeostasis in facing specific stress challenges.</div><div>We propose that mice lacking miR-34 s may represent a new valuable model to study the molecular mechanisms underlying the detrimental effect of psychosocial stress on the heart.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114984"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contextual enhancement on binge-like overconsumption of palatable sugar in mice 小鼠对可口糖暴饮暴食的情境增强。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-04 DOI: 10.1016/j.physbeh.2025.114981

Hiroshi Matsui, Yasunobu Yasoshima

{"title":"Contextual enhancement on binge-like overconsumption of palatable sugar in mice","authors":"Hiroshi Matsui, Yasunobu Yasoshima","doi":"10.1016/j.physbeh.2025.114981","DOIUrl":"10.1016/j.physbeh.2025.114981","url":null,"abstract":"<div><div>Binge eating disorder is an eating disorder characterized by the excessive intake of food within a short period, often beyond physiological needs. Studies using animal models have shown that binge eating animals consume food in quantities that surpass physiological necessity, and that the neural mechanisms underlying this behavior overlap with those involved in habit formation. Habitual behaviors are thought to be automatic responses acquired through extended behavioral training and are dependent on the context in which they were learned. Therefore, this study hypothesized that binge eating has a context-dependent component. We investigated whether the excessive palatable sugar intake observed in an animal model of binge eating is triggered by an associated context as a learned behavior. To test this, mice were trained to develop binge-like sugar consumption in a specific context. During the test phase, we reduced the animals’ hedonic needs for sugar solution by providing a two-hour satiety period. Sugar solution was then presented in both the training context and a novel context (Experiment 1) or a negative context (Experiment 4). The results showed that in the training context, the mice continued to consume sugar solution at levels similar to those observed at the onset of the satiation. In contrast, this context-induced sugar consumption was not observed in the novel context (Experiment 2), while a follow-up experiment employing conditioned place preference demonstrated the existence of contextual learning itself (Experiment 3). These findings collectively suggest that, like habitual behaviors, binge eating is induced under in the context-dependent manner and insensitive to the consequence of the behavior.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114981"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of co-housing and social isolation on the gut microbiota 共同居住和社会隔离对肠道微生物群的影响。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-06-03 DOI: 10.1016/j.physbeh.2025.114980

Yajing Song , Anjani Maley , Jerusha Boyineni , Siva Reddy Challa , Casimir A Fornal , Marcelo Bento Soares , Sergey Malchenko , Krishna Kumar Veeravalli , Peter Gyarmati

{"title":"Effects of co-housing and social isolation on the gut microbiota","authors":"Yajing Song , Anjani Maley , Jerusha Boyineni , Siva Reddy Challa , Casimir A Fornal , Marcelo Bento Soares , Sergey Malchenko , Krishna Kumar Veeravalli , Peter Gyarmati","doi":"10.1016/j.physbeh.2025.114980","DOIUrl":"10.1016/j.physbeh.2025.114980","url":null,"abstract":"<div><div>It is well documented that both social connection patterns and gut microbiota influence individuals’ mental and physical health through multiple systems, such as the neuroendocrine, immune, and metabolic systems. Social connections shape the gut microbiota, and altered gut microbiota in turn modulates the host’s social behavior in a feedback loop. We therefore hypothesize that the gut microbiota mediates the interaction between social connection patterns and individual well-being. In this pilot study, the effects of co-housing (CH) and social isolation (SI) on shaping gut microbiota community structure were investigated using a mouse model. Twenty-four 3-week-old mice were randomly divided into CH and SI groups (6/sex/group) for 8 weeks. CH mice were socially housed in cages containing 3 mice per cage, while SI mice were individually housed in cages with opaque barriers to prevent interaction. We found that CH increased gut microbiota diversity and stabilized its composition, whereas SI decreased gut microbiota diversity and resulted in more compositional fluctuations—changes previously associated with immunity, metabolism, and neurodevelopment. Meanwhile, this work also demonstrates that including litter controls may be pivotal in establishing a stable baseline for gut microbiota research.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"299 ","pages":"Article 114980"},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0