Physiology & Behavior最新文献

{"title":"Predicting fluctuations in cardiac interoceptive accuracy and sensibility through additional heart rate variability reductions in everyday life","authors":"Christian Rominger,&nbsp;Andreas R. Schwerdtfeger","doi":"10.1016/j.physbeh.2025.114928","DOIUrl":"10.1016/j.physbeh.2025.114928","url":null,"abstract":"<div><div>Cardiac interoception, assessed in terms of accuracy (IAcc) and sensibility (IS; beside others), is important for health and wellbeing. Ecological momentary assessment studies exploring the dynamics of cardiac interoception showed substantial fluctuations of IAcc and IS in everyday life. States of increased (physiologically indicated) stress, such as decreased heart rate variability (HRV), may hamper interoceptive skills, while more relaxed states (higher HRV) seem to go along with increased IAcc. We built on this and investigated if higher (physiological) stress indicated via HRV reductions independent of metabolic needs (i.e., additional HRV reduction, AddHRVr) could (differentially) predict IAcc and IS, respectively. In an initial sample of 119 participants, with data of (up to) three consecutive days, we simulated the predictive value of AddHRVr. We found that AddHRVr before an ambulatory cardiac interoception task predicted poor IAcc and higher IS. We replicated this pattern of findings in an independent sample of 66 participants. Both studies provide first insights into the dynamics of IAcc and IS in daily life, which seems to differ when following AddHRVr. This lays the groundwork for just in time adaptive interventions (JITAIs) supporting individuals in states of high vulnerability and promoting cardiac interoceptive skills.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"296 ","pages":"Article 114928"},"PeriodicalIF":2.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytochrome-C-oxidase expression in the subiculum and anterior thalamic nuclei of rats increases following training in an extrapolation of serial stimulus patterns task","authors":"Daniel Giura da Silva ,&nbsp;Mateus Torres-Cruz ,&nbsp;Ammir Yacoub Helou ,&nbsp;Gilberto Fernando Xavier","doi":"10.1016/j.physbeh.2025.114926","DOIUrl":"10.1016/j.physbeh.2025.114926","url":null,"abstract":"<div><div>The brain continuously monitors the environment, comparing predictions based on memories of past regularities and action plans with current sensory information. The subiculum and the anteroventral thalamus have been proposed to play critical roles in this Generator of Predictions System (GPS). This study evaluated the hypothesis that cytochrome C oxidase (COX) expression changes in the subiculum and anterior thalamic nuclei of subjects exposed to training and testing in an extrapolation of serial stimulus pattern task that stimulates the generation of predictions. Shortly, male Wistar rats were trained to run through a straight alleyway to receive variable amounts of sunflower seeds. In each session (one session per day), the animals ran 4 successive trials, receiving different amounts of sunflower seeds in each trial. Subjects exposed to the monotonic pattern (M) received 14, 7, 3, and 1 sunflower seeds. Subjects exposed to the non-monotonic pattern (NM) received 14, 3, 7, and 1 sunflower seeds. The animals were trained for 20 sessions. In the 21st session, a fifth trial, never experienced before by the subjects, was added immediately after the fourth trial. An additional control group was not exposed to training in the task, allowing evaluation of COX expression in untrained subjects. Data revealed increased COX activity in the anteroventral thalamus, and in the ventral subiculum, all related to training in the NM, but not M, schedule of reward. Data also revealed reduced COX activity in the dorsal portion of the subiculum, restricted to subjects trained with the NM serial pattern. These figures suggest that the anteroventral thalamus and the ventral and dorsal subiculum are engaged in the acquisition of extrapolation of serial stimulus pattern tasks, thus opening novel avenues to studying neural brain circuits involved in generating predictions. One possibility, for instance, would be to evaluate the time course of these COX activations in association with training in the M and NM serial patterns.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"296 ","pages":"Article 114926"},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A social conditioned place preference test and pair maintenance in the monogamous zebra finch","authors":"Martin R. Kim ,&nbsp;Chelsea M. Haakenson ,&nbsp;Jane A. Brown ,&nbsp;Gregory F. Ball ,&nbsp;Nora H. Prior","doi":"10.1016/j.physbeh.2025.114925","DOIUrl":"10.1016/j.physbeh.2025.114925","url":null,"abstract":"<div><div>Social relationships are essential for a wide range of species, including humans. The mechanisms of pair formation and maintenance appear to be distinct, although relatively little is known about pair maintenance compared to bond formation. A social conditioned place preference (SCPP) test, a paradigm not often used, could be used to reveal differences in the mechanisms of bond formation and maintenance. Here we used the SCPP test across two experiments to investigate how the behavioral and neuroendocrine mechanisms of social affiliation change over the course of pair bonding in the monogamous zebra finch. In our procedure, we had three 30 min phases: preconditioning occurring on Day 1, followed by conditioning and postconditioning, both on Day 2. In our first experiment, we simply asked whether courting and paired dyads would form SCPPs in this assay. We found evidence that courting, but not paired birds, formed SCPPs. This was particularly evident for courting females. Courting and paired dyads also engaged in different behaviors during the conditioning phase. Despite these effects of social context on behavior, there was no clear relationship between these behavioral differences and the formation of SCPPs for courting males or females. We next tested whether pharmacological treatment with D1 and D2 receptor agonists would alter the effects of social context on the formation of SCPPs. Specifically, we hypothesized that treatment with a D1-agonist (SKF 38393) would block the formation of SCPPs in courting dyads and that activation of D2-like receptors (quinpirole) would induce SCPPs in already established pairs. In contrast with Experiment 1, we did not see any groups forming SCPPs, but paired males, regardless of pharmacological treatment, appeared to form aversions to the conditioning side. Furthermore, there was significantly less courtship and affiliative behavior in the second experiment. Combined, this leads us to suspect that coupling the SCPP with an s.c. injection made the entire procedure too aversive to reveal any SCPP. Despite this, there were subtle effects of pharmacological manipulation on social behavior during the conditioning phase. All together, the results from our two experiments (1) suggest that there are differences in the mechanisms by which courting and paired dyads relate to their partner in novel environments, (2) highlight the differences in social interactions between courting and paired birds, and (3) leave open the possibility that dopamine signaling differentially shapes social behavior and the formation of SCPPs in courting and paired birds.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"297 ","pages":"Article 114925"},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding social touch: A multi-modal exploration of tactile perception, gender and culture","authors":"Helen J. Powell ,&nbsp;Jason L. He ,&nbsp;Khushika Magnani ,&nbsp;Ke Hu ,&nbsp;Lauren Barnes ,&nbsp;Ria Beßler ,&nbsp;Vikram S. Chib ,&nbsp;Nicolaas A. Puts","doi":"10.1016/j.physbeh.2025.114918","DOIUrl":"10.1016/j.physbeh.2025.114918","url":null,"abstract":"<div><div>Social touch plays a vital role in human development, communication, and general well-being. However, the mechanisms underlying how social touch elicits pleasant or aversive responses are poorly understood. Furthermore, it remains unclear how alterations in sensory processing, at both the perceptual level (i.e. detection and discrimination of stimuli) and behavioral level (i.e. response to stimuli), shape the experience of social touch, in addition to contextual factors such as gender and culture. In the current study, we used vibrotactile psychophysics and a novel social touch paradigm to assess the association between tactile perceptual differences and social touch preference in two cross-cultural cohorts (56 adults in the UK and 21 adults in Singapore). We found that participants with poorer tactile discrimination thresholds in both cohorts had lower pleasantness ratings for social touch, and higher pleasantness ratings for non-social touch, with a stronger predictive effect than gender or culture alone. We also found evidence of strong gender effects, such that female participants rated different-gender touch as less pleasant than males. Singaporean participants also showed lower preferences for social touch than UK participants. Our results suggest a bottom-up perceptual mechanism in linking poorer tactile discrimination with greater social touch aversion in adults. Furthermore, while some cultural differences between cohorts were observed at the contextual level, perceptual contributions to social touch preference appeared to be conserved, suggesting a shared biological mechanism between cultures. These findings could have implications for clinical conditions that are characterised by altered sensory and social processing.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"297 ","pages":"Article 114918"},"PeriodicalIF":2.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity","authors":"Rafik Dali ,&nbsp;Fanny Langlet","doi":"10.1016/j.physbeh.2025.114917","DOIUrl":"10.1016/j.physbeh.2025.114917","url":null,"abstract":"<div><div>Hypothalamic inflammation has been identified as a critical factor driving the development of obesity and associated metabolic disorders. This inflammation-related disruption of energy balance relies on alterations in metabolic cues sensing and hypothalamic cellular functions, together leading to overeating and weight gain. Within the hypothalamic cellular networks controlling energy balance, recent studies have highlighted the significance of glial dysfunction in these processes, suggesting that these cells could provide new avenues for weight loss therapies. Glia rapidly activates following the consumption of a high-fat diet, even after a very short exposure, and contributes to the disruption of the entire system through inflammatory crosstalk.</div><div>This review explores recent progress in understanding the molecular interactions between glial cells and neurons in hypothalamic inflammation related to obesity, diabetes, and associated complications. Notably, it highlights specialized ependymal cells called tanycytes, whose role is still underestimated in hypothalamic inflammation, and examines the potential for targeting this cell type as a treatment strategy for metabolic disorders.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"296 ","pages":"Article 114917"},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity circuit training improves cognitive performance independent of changes in sBDNF levels in active college students","authors":"Alberto Jiménez-Maldonado ,&nbsp;Barbara Moura Antunes ,&nbsp;Rubén Avilés Reyes ,&nbsp;Iván Rentería ,&nbsp;Alberto Blanco-Salazar ,&nbsp;José Moncada-Jiménez ,&nbsp;Isaac A. Chávez Guevara ,&nbsp;Juan Pablo Machado-Parra ,&nbsp;Fabio Santos Lira ,&nbsp;Fabrício Eduardo Rossi","doi":"10.1016/j.physbeh.2025.114916","DOIUrl":"10.1016/j.physbeh.2025.114916","url":null,"abstract":"<div><div>High-intensity circuit training (HICT) is an exercise modality converging aerobic and resistance exercises executed at high-intensity interspersed by recovery periods. During the HICT, the participants use their body weight as resistance. The impact of HICT on metabolic and cardiovascular markers has been reported, the effect of HICT on brain function remains unknown. The current study was focus to evaluate the impact of 24 HICT sessions on the serum BDNF (sBDNF) levels and cognition skills in young adults. Fifteen college students (22.1 ± 5.3 yr.) were randomly assigned to a control (CTRL) (<em>n</em> = 7) or a HICT (<em>n</em> = 8) group. The CTRL group continued their daily activities without restricting their physical activities, the HICT group carried out 24 HICT sessions. The sBDNF levels of all participants pre- and post-HICT intervention were determined by ELISA method. Visual memory, verbal memory, semantic verbal fluency, and attention were evaluated with specific neuropsychological tests. The heart rate variability (HRV) was recorded at rest in the supine position (5 min) for both groups at the beginning of the HICT program and 24 h after the intervention. The sBDNF levels increased in both groups at the end of the study (<em>p</em> &lt; 0.0001). Visual memory (delayed recall) and long-term verbal memory significantly improved after HICT (<em>p</em> &lt; 0.01). The HRV was unchanged by HICT. In conclusion, HICT might be a feasible method to improve cognition abilities in active young adults, and it is becoming a good option for college students since the intervention did not induce physiological stress in the participants.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114916"},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cold-water immersion on energy expenditure, ad-libitum energy intake and appetite in healthy adults","authors":"Marie J. Grigg ,&nbsp;C. Douglas Thake ,&nbsp;Judith E. Allgrove ,&nbsp;David R. Broom","doi":"10.1016/j.physbeh.2025.114914","DOIUrl":"10.1016/j.physbeh.2025.114914","url":null,"abstract":"<div><h3>Introduction</h3><div>Cold-water immersion is a popular method typically used to reduce exercise induced muscle damage and improve health and wellbeing. Despite these benefits, there is emerging evidence to suggest the temperature of the water exposure can influence energy intake in the subsequent hours. The study aim was to investigate the influence of water temperature on energy expenditure and post-water immersion <em>ad-libitum</em> energy intake in resting adults. Participants with a range of body masses, but otherwise healthy and physically active males (n = 10) and females (n = 5), participated in three randomised trials in a repeated measures crossover design, with a minimum of 7-days apart. Participants were immersed to sternum level for 30-minutes in either cold-water (16 °C), thermoneutral-water (35 °C) or a no-water thermoneutral ambient air control (26 °C). Participants completed appetite related visual analogue scales throughout and were presented with an <em>ad-libitum</em> homogenous pasta meal and asked to eat until ‘comfortably full’.</div></div><div><h3>Results</h3><div>Repeated measures ANOVA showed participants consumed more energy after immersion in cold-water (2783 ± 909 kJ) versus both thermoneutral-water (1817 ± 862 kJ) and thermoneutral ambient air (1894 ± 233 kJ). There were no differences in any of the appetite VAS. Core temperature remained stable throughout the 30 min immersion period across trials, however an after-drop in core temperature was observed for 15 mins following cold-water immersion when compared to both thermoneutral water (P &lt; 0.001), and thermoneutral air (P = 0.004). Although the exact mechanisms are yet to be elucidated, further research is required to identify if the after-drop in core temperature is a potential mechanism responsible for compensatory food intake post cold-water immersion.</div></div><div><h3>Conclusion</h3><div>When presented with an <em>ad-libitum</em> meal directly after cold-water immersion, participants consumed more in comparison to both thermoneutral water immersion and thermoneutral ambient air. With cold water immersion becoming popular, these findings have practical and clinical relevance for individuals’ conscious about body mass management.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"296 ","pages":"Article 114914"},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the influence of thermal environment on miners ' physiological and cognitive ability in deep mining face","authors":"Yi Chai ,&nbsp;Yungang Wang ,&nbsp;Guoxun Jing ,&nbsp;Le Peng","doi":"10.1016/j.physbeh.2025.114915","DOIUrl":"10.1016/j.physbeh.2025.114915","url":null,"abstract":"<div><h3>Objective</h3><div>In order to reduce the impact of heat damage and reduce the incidence of accidents, this study will conduct regression analysis and cognitive ability test to quantify the relationship between temperature level and miners' physiological state, and monitor the impact of temperature on miners ' cognitive ability and working state.</div></div><div><h3>Methods</h3><div>Controlling different temperature levels as variables, with the help of PhysioPlux physiological recorder, two physiological indexes of heart rate variability and skin electricity were selected to study the physiological changes of miners caused by different temperature levels, and the influence of temperature on cognitive ability was studied based on cognitive ability test.</div></div><div><h3>Results</h3><div>(1) With the increase of temperature, the HRV time domain indexes RMSSD and SDNN of the subjects increased at different rates. When the temperature was increased again, the two physiological indexes decreased at a faster rate within the normal range. The skin conductance SC value of the subjects increased with the increase of temperature, the linear regression equation between different temperature levels and RMSSD / SC was established. (2) The cognitive response speed increases first and then slows down with the increase of temperature. The cognitive accuracy AC decreases with the increase of temperature. The increase of temperature reduces the cognitive ability.</div></div><div><h3>Conclusion</h3><div>Determining the physiological threshold and monitoring the status of coal miners is helpful to establish an underground safety early warning system and minimize the risk of coal mine accidents.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114915"},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting autonomic activity predicts the efficiency of approach-avoidance responses to emotional faces","authors":"Mitsuhiko Ishikawa ,&nbsp;Ayumi Yoshioka","doi":"10.1016/j.physbeh.2025.114912","DOIUrl":"10.1016/j.physbeh.2025.114912","url":null,"abstract":"<div><div>In social situations, adaptive responses to another are crucial for smooth interactions, requiring immediate actions based on contextual cues. While previous studies have demonstrated the importance of autonomic nervous system (ANS) in emotional processing, the relationship between resting ANS activity and approach-avoidance responses to emotional faces remains unclear. This study investigated how resting autonomic nervous activity measured by skin conductance level (SCL) relates to approach-avoidance decisions in response to facial expressions. After recording resting SCL, participants performed an approach-avoidance task (AAT) with emotional facial stimuli. The task required either approaching happy faces while avoiding angry faces (value-congruent condition) or the opposite pattern (value-incongruent condition). Reaction times (RTs) were significantly faster in value-congruent conditions compared to value-incongruent conditions. The resting SCL showed a significant correlation with the congruency effect (RT difference between conditions). These findings suggest that resting autonomic states, particularly sympathetic arousal, may contribute to the efficiency of approach-avoidance responses. Higher sympathetic activity at rest predicted more efficient responses to emotional faces, potentially reflecting enhanced action readiness. These results extend previous findings on ANS involvement in emotional processing to the domain of approach-avoidance responses to social stimuli, highlighting the role of physiological states in adaptive social behaviour.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114912"},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tactile Stimulation and its Impact on Barrel Cortex Neuron Receptive Fields in Whisker-Deprived male Rats","authors":"Mohammad Reza Afarinesh ,&nbsp;Bi Bi Marzieh Ahmadi ,&nbsp;Mansoureh Sabzalizadeh ,&nbsp;Faly Golshan ,&nbsp;Vahid Sheibani","doi":"10.1016/j.physbeh.2025.114911","DOIUrl":"10.1016/j.physbeh.2025.114911","url":null,"abstract":"<div><div>Understanding the enhancement of neuronal performance through the interaction of various sensory stimuli and evaluating how these interactions influence neuronal responses and sensorimotor behaviors is critical. This study investigates the simultaneous effects of tactile stimulation (TS) and sensory deprivation of whiskers on the receptive field properties of barrel cortex neurons in Wistar rats. Male rats were subjected to whisker deprivation (WD) or TS for 21 days from birth. Neuronal responses to controlled deflections of principal and adjacent whiskers were assessed using single-unit recordings from the barrel cortex. Results indicated that while WD reduced the excitatory receptive fields of neurons, the magnitude of ON and OFF responses returned to control group levels following TS, suggesting improved neuronal function. These findings demonstrate that tactile stimulation can compensate for deficits caused by sensory deprivation.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"295 ","pages":"Article 114911"},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}