Physiology & Behavior最新文献

{"title":"Early rearing of European seabass (Dicentrarchus labrax) with mild current enrichment modifies fish swimming behavior without altering their growth performance","authors":"Leonardo J. Magnoni ,&nbsp;Xavier Cousin ,&nbsp;Isabelle Leguen ,&nbsp;Carlos Espirito-Santo ,&nbsp;Frédéric Clota ,&nbsp;Stéphane Lallement ,&nbsp;Marie-Laure Bégout","doi":"10.1016/j.physbeh.2024.114742","DOIUrl":"10.1016/j.physbeh.2024.114742","url":null,"abstract":"<div><div>The implementation of conditions that favor optimum swimming activity (e.g., suitable flow regimes), has been associated with enhanced growth and improved welfare in some farmed fish species. Despite the importance of European seabass in aquaculture, the potential beneficial effects of rearing flow conditions have not been sufficiently explored in this species. This study investigates how the application of fast (F, 0.01–0.20 m s^-1) or slow (S, &lt;0.01 m s^-1) steady flows in rearing tanks for 75-77 days affected physiological and behavioral traits in seabass fingerlings. Growth performance, external and internal morphology, and several physiological variables, including hematocrit, plasma cortisol concentration, and osmotic and ionic balance were not affected by flow conditions during rearing. Also, behavioral tests implemented in groups or isolated individuals suggest that coping styles were not affected by the two tank-rearing conditions. On the contrary, the swimming behavior assessed in tests was modified by the flow condition experienced during rearing. Mean swimming speed, peak acceleration, swimming distance, angular velocity, and meander showed some variability across different tests and time, although consistently displaying higher values in seabass reared in the F condition, suggesting increased activity and more consistent swimming patterns in that group. However, the cumulative time in proximity between individuals measured in behavioral group tests suggested that group cohesion was variable, without displaying differences between F and S groups. These findings have particularly important implications for fish welfare and may suggest plasticity in the behavioral response to rearing conditions for this species, although not affecting the assignment of the individuals to the different coping styles.</div></div><div><h3>Summary statement</h3><div>We investigated how mild current enrichment applied during early rearing in seabass modifies physiological and behavioral responses involving swimming activity, exploring the potential associations to fish welfare.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"289 ","pages":"Article 114742"},"PeriodicalIF":2.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteomic signature of chronic psychosocial stress in mice","authors":"Lewis A. O'Connor ,&nbsp;Thieza G. Melo ,&nbsp;Anna V. Golubeva ,&nbsp;Francisco Donoso ,&nbsp;Caitriona Scaife ,&nbsp;Jane A. English ,&nbsp;Yvonne M. Nolan ,&nbsp;Olivia F. O'Leary","doi":"10.1016/j.physbeh.2024.114743","DOIUrl":"10.1016/j.physbeh.2024.114743","url":null,"abstract":"<div><div>Chronic stress significantly impacts both physical and mental wellbeing, increasing risk of cardiovascular disease, immune dysregulation, and psychiatric conditions such as depression and anxiety disorders. The plasma proteome is a valuable source of biomarkers of health and disease, but the limited number of studies exploring the potential of the plasma proteome as a biomarker for stress-related disorders underscores the importance of further investigation of the effects of chronic stress on the plasma proteome. The aim of this study was to examine the effect of a 5-week chronic psychosocial stress paradigm on the plasma proteome in mice and to determine if any affected proteins correlated with stress-induced changes in behaviour and physiology, and thus might represent biomarkers of negative impacts of chronic stress. Using LC-MS/MS proteomic analysis, 38 proteins in the mouse plasma proteome were identified to be affected by chronic psychosocial stress. Functional analysis revealed that these proteins clustered into biological functions including inflammatory response, regulation of the immune response, complement and coagulation cascades, lipid metabolic process, and high-density lipoprotein particles. Correlation analyses of the identified proteins with stress-induced behavioral or physiological changes stress revealed significant correlations between stress-induced anxiety-like behaviour and Phosphatidylinositol-glycan-specific phospholipase D, Complement C2, Epidermal growth factor receptor, Prosaposin, Actin-related protein 2/3 complex subunit 1B, Maltase-glucoamylase, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA and Fibrinogen-like protein 1. Chronic psychosocial stress blunted acute stress-induced corticosterone release, and this correlated with abundance of Pyrethroid hydrolase Ces2a; N-fatty-acyl-amino acid synthase/hydrolase Pm20d1, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, Alpha-2-macroglobulin-P and L-selectin. Finally, stress-induced reductions in both brown and epididymal fat correlated with Phosphatidylinositol-glycan-specific phospholipase D, Complement C2, Epidermal growth factor receptor, Kininogen-1, Apolipoprotein M, Angiopoietin-related protein 3, Proprotein convertase subtilisin/kexin type 9, and Lipopolysaccharide-binding protein. These findings demonstrate that chronic psychosocial stress induces alterations in plasma proteins implicated in key biological processes and pathways related to stress response, immune function, and lipid metabolic regulation. Further investigation into these proteins may provide new avenues for identification of biomarkers or mediators of stress-induced pathology.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"289 ","pages":"Article 114743"},"PeriodicalIF":2.4,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of acute and chronic therapeutic cooling on cognitive performance and well-being","authors":"Joseph Knill-Jones ,&nbsp;Gareth Shadwell ,&nbsp;Howard T. Hurst ,&nbsp;Chris Mawhinney ,&nbsp;Jonathan K. Sinclair ,&nbsp;Robert Allan","doi":"10.1016/j.physbeh.2024.114728","DOIUrl":"10.1016/j.physbeh.2024.114728","url":null,"abstract":"<div><h3>Purpose</h3><div>Research regarding the effect cold-water immersion (CWI) has on cognitive performance often uses excessive cooling protocols (&gt;1-hour) to measure the detrimental impact prolonged cold exposure has on cognition. Previous studies have not considered shorter CWI protocols, similar to that used in recovery and wellness practices (∼10 min).</div></div><div><h3>Aims</h3><div>To investigate a more ecologically valid CWI protocol on cognition, well-being and sleep in an acute and chronic manner. It was hypothesised that a therapeutic CWI protocol would improve well-being, and sleep and have no detrimental effect on cognition.</div></div><div><h3>Methods</h3><div>Thirteen healthy participants (20.85±2.15 years), (169.96±7.77 cm), (72.03±14.92 kg), (27.67±9.55 BF%) volunteered to complete a 4-week CWI protocol. Participants were immersed in cold water (10.42±0.59 °C) 3-times a week for 4-weeks. Cognitive performance (Stroop &amp; TMT), well-being (WEMWBS, PSWQ, GAD-7, SHS) and sleep (PSQI) were measured acutely and chronically over the 4-week protocol along with thermoregulatory measures (Tsk, Tco, thermal comfort).</div></div><div><h3>Results</h3><div>Results show that CWI had no detrimental impact on cognitive performance, with Stroop performance &amp; well-being seeing no differences acutely or chronically. Alternatively, the trail making test showed significant improvement from baseline (TMT-A 15.17±4.81-seconds, TMT-B 39.68±15.12-seconds) to week-3 (TMT-A 11.06±3.29-seconds, TMT-B 26.18±10.23-seconds). A reduction in sleep disturbances was seen from baseline scores of 7.85±3.44 AU to the end of week-3 measures 5.75±3.77 AU.</div></div><div><h3>Conclusion</h3><div>Therapeutic cooling can improve sleep quality when utilised in short frequent doses (3 times per week, for 4-weeks) and is not detrimental to cognitive performance, improving certain aspects of executive function.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"289 ","pages":"Article 114728"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary food restriction does not affect circulating corticosterone in obesity-prone or -resistant male and female rats","authors":"Julie E. Finnell ,&nbsp;Carrie R. Ferrario","doi":"10.1016/j.physbeh.2024.114729","DOIUrl":"10.1016/j.physbeh.2024.114729","url":null,"abstract":"<div><div>Food restriction in rodents can increase circulating corticosterone, which reflects activation of physiological stress responses. These responses affect a myriad of behaviors and physiological processes and can increase the risk of obesity. Most studies in this area have used experimenter-imposed restriction. However, rats will voluntarily restrict their food intake if they are returned to chow after a period of access to sugary, fatty “junk food” (JF) diet. Here we examine the effects of voluntary food restriction in obesity-prone and -resistant male and female rats on circulating corticosterone concentrations and determine whether corticosterone release in response to acute stress differs in groups with a history of JF consumption.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114729"},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is androstadienone a human male pheromone? More research is needed","authors":"Junyi Gan ,&nbsp;Yin Wu ,&nbsp;Xue Lei ,&nbsp;Chengyang Han","doi":"10.1016/j.physbeh.2024.114733","DOIUrl":"10.1016/j.physbeh.2024.114733","url":null,"abstract":"<div><div>Androsta-4,16‑dien-3-one (androstadienone, AND), a steroid predominantly found in male secretions, has been associated with a variety of sex-specific effects on emotion, physiological states, cognition, and neural activity. An expanding body of literature has explored the influence of AND on human behavior and perception, leading to its frequent description as a “putative human sex pheromone.” This article reviews the existing research on the physiological, cognitive, and neuroimaging effects of AND, critically assessing the evidence regarding its classification as a human sex pheromone. Additionally, it underscores the need for methodological standardization and rigor in future studies to establish clearer conclusions. Based on current evidence, the categorization of AND as a “human sex pheromone” remains inconclusive, highlighting the necessity for continued investigation. Future research directions are suggested to further elucidate AND's potential effects and applications.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114733"},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cafeteria diet and caloric restriction affect metabolic but not behavioral characteristics in male Wistar rats","authors":"Christakis Kagios ,&nbsp;Susanne Hetty ,&nbsp;Alfhild Grönbladh ,&nbsp;Maria J Pereira ,&nbsp;Jan W Eriksson ,&nbsp;Erika Roman","doi":"10.1016/j.physbeh.2024.114731","DOIUrl":"10.1016/j.physbeh.2024.114731","url":null,"abstract":"<div><div>This study aimed to evaluate the effects of a cafeteria diet and caloric restriction on behavioral and metabolic profiles of adult male Wistar rats. The rats were randomly divided into three groups (<em>n</em> = 12/group) and from 10 weeks of age fed either ad libitum standard rat chow (control group), ad libitum cafeteria diet in addition to standard chow (diet-induced obesity (DIO) group) or kept on caloric restriction (at 85% weight of controls; restricted group) for a period of 12 weeks. Body weight was assessed twice per week and glucose levels were measured at three times during the 12-week period. At week 11 the animals were behaviorally profiled using the multivariate concentric square field™ (MCSF) test. After 12 weeks of diet the animals were euthanized, blood collected, relative organ weights were assessed and plasma or serum levels of insulin, glucose, and lipid profile were measured. The DIO group gained 23% more weight than the control group (<em>p</em> &lt; 0.001) and increased adipose tissue weight in comparison to the control (<em>p</em> &lt; 0.001) and restricted (<em>p</em> &lt; 0.001) groups. Glucose was significantly increased (<em>p</em> &lt; 0.001) only during the second measurement at week 7 and insulin levels were elevated in the DIO group compared to controls and restricted groups (<em>p</em> &lt; 0.01; <em>p</em> &lt; 0.001, respectively). Plasma cholesterol levels were reduced for both DIO (<em>p</em> &lt; 0.01) and restricted (<em>p</em> &lt; 0.001) groups relative to controls. Adiponectin and leptin levels were higher for the DIO group in comparison to both the control (<em>p</em> &lt; 0.001; <em>p</em> &lt; 0.05) and restricted (<em>p</em> &lt; 0.001; <em>p</em> &lt; 0.001) groups. Thus, the two diets led to significant changes in body weight gain, adiposity, and metabolism. However, they did not alter the behavioral profiles in the MCSF test, suggesting that activity, exploration, risk assessment, risk taking or shelter seeking remained unaffected by the dietary interventions. The current findings suggest that an increase or reduction in energy intake resulted in no behavioral effects, despite the accompanying glycemic alterations potentially related to diabetes development.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114731"},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal bisphenol A exposure has an age- and dose-dependent association with thyroid allostasis adaptive response, as well as anxiogenic-depressive-like and asocial behaviors in juvenile and adult male rats","authors":"Heba-Tallah Abd Elrahim Abd Elkader ,&nbsp;Ahmed S. Al-Shami ,&nbsp;Hanaa Said Darwish","doi":"10.1016/j.physbeh.2024.114732","DOIUrl":"10.1016/j.physbeh.2024.114732","url":null,"abstract":"<div><div>Thyroid hormones are essential for brain development, and a shortage throughout the fetal and postnatal periods can result in mood disorders. Perinatal exposure to bisphenol A (BPA) affects thyroid activity and dependent processes indirectly during pregnancy or early postnatal life. This is particularly important because it may cause changes in tissue ontogeny, increasing the risk of developing disorders later in life. The study aimed to investigate the consequences of thyroid hormone deficiency on anxiety, social, and depressive behaviors, as well as disruption in thyroid peroxidase (TPO) gene expression, which influences the NF-κB/Nrf-2/HO-1/iNOS signaling pathway, leading to oxidative stress, inflammation, and DNA fragmentation in perinatal BPA exposure (PND18), and whether these effects can be observed in juvenile (PND60) and adult (PND95) male offspring rats. BPA increased anxiety-like behavior while decreasing sucrose preference and sociability on a choice task between novel conspecific male rats and enhanced immobility on the forced swim test. Perinatal exposure to BPA causes thyroid insult by overproducing ROS, increasing iNOS, and NF-κB levels—these effects, in turn, down-regulate Nrf-2/HO-1 signaling, resulting in DNA fragmentation within thyroid tissues. Furthermore, perinatal BPA exposure for 60 and 95 days resulted in a significant fold decrease in TPO mRNA levels in the thyroid tissues, with an insignificant fold rise in TPO expression levels in BPA 50–60. In conclusion, the present study found that perinatal BPA exposure induced thyroid allostasis-adaptive response by inhibiting the NF-κB/Nrf-2/HO-1/iNOS signaling pathway and altering the transcriptional expression of TPO, where TSH reinforced a possible association with TPO activity, disrupting thyroid hormone synthesis in juvenile rats and gradual deterioration reaching the adult stage.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114732"},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walking economy and exercise efficiency in successful weight loss maintainers","authors":"Seth A. Creasy ,&nbsp;Rebecca C. Rosenberg ,&nbsp;Danielle M. Ostendorf ,&nbsp;Ray Browning ,&nbsp;Edward L. Melanson ,&nbsp;Zhaoxing Pan ,&nbsp;Victoria A. Catenacci","doi":"10.1016/j.physbeh.2024.114730","DOIUrl":"10.1016/j.physbeh.2024.114730","url":null,"abstract":"<div><h3>Purpose</h3><div>Following short-term weight loss, the energetic cost of transport decreases and exercise efficiency increases. Whether changes persist during long-term weight maintenance is unknown.</div></div><div><h3>Methods</h3><div>We compared walking economy and exercise efficiency in weight loss maintainers (WLM, maintaining ≥13.6 kg weight loss for ≥1 year), controls without obesity (NC, BMI similar to current BMI of WLM), and controls with overweight/obesity (OC, BMI similar to pre-weight loss BMI of WLM). Energy expenditure (EE) and respiratory quotient were measured using indirect calorimetry at rest, while standing, and during treadmill walking. Gross and net energetic cost of transport (J/kg/m) was measured during level treadmill walking at 0.75, 1.12, and 1.52 m/s. Gross, net, and delta efficiency (%) were measured during inclined treadmill walking (2 %, 4 %, and 6 % grade) and a constant speed (1.12 m/s).</div></div><div><h3>Results</h3><div>WLM (n = 32, BMI: 23.8 ± 2.3 kg/m²) and NC (n = 28, BMI: 22.7 ± 1.6 kg/m²) had significantly lower EE (kJ/min) compared to OC (n = 26, BMI: 33.0 ± 4.5 kg/m²) during rest, standing, and walking (p &lt; 0.01). Net energetic cost of transport was significantly lower in WLM compared to OC at 1.12 and 1.52 m/s (p &lt; 0.05). Net efficiency was significantly greater in WLM compared to OC while walking (p ≤ 0.05). There were no significant differences between WLM and NC for any measures of economy or efficiency.</div></div><div><h3>Conclusion</h3><div>WLM had lower walking economy and greater walking efficiency compared to OC, but there were no differences between WLM and NC. Thus, individuals maintaining significant weight loss may be successful with long-term weight loss, in part, due to resistance against adaptive reductions in walking energetics.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114730"},"PeriodicalIF":2.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste and oral somatosensation: Role of PTC bitter sensitivity, gender, and age","authors":"Mariano Mastinu,&nbsp;Andreas Püschner,&nbsp;Saskia Gerlach,&nbsp;Thomas Hummel","doi":"10.1016/j.physbeh.2024.114727","DOIUrl":"10.1016/j.physbeh.2024.114727","url":null,"abstract":"<div><div>Sensitivity to the bitterness of phenylthiocarbamide (PTC) is considered to be linked to general taste perception, which is higher in women, and exhibits a slight decrease with age. Additionally, PTC sensitivity may contribute to somatosensory perception of spiciness and astringency. However, controversial data have been reported. This study investigates the relation between PTC perception, age, and gender on taste and somatosensory sensitivity using the Seven-iTT. A total of 200 healthy participants were classified based on their PTC perception, and subjects underwent an extended version of Seven-iTT to identify and rate the intensity of twelve stimuli. Results indicated that individuals classified as Tasters (T) exhibited higher taste scores compared to Non-Tasters (NT) for PTC, with age serving as a significant factor (<em>p</em> ≤ 0.009). Women outperformed men only among NT (<em>p</em> = 0.019). Older T demonstrated higher taste sensitivity than NT, suggesting that PTC status might act as a protective factor of gustatory function in aging. While PTC taster status significantly affected the intensity of sweet, salty, and bitter sensations (<em>p</em> ≤ 0.032), it had minimal impact on the intensity of somatosensory sensations (capsaicin and tannins). The combined use of Seven-iTT and the investigation of PTC status show promise for applications in research and clinical practice, offering a comprehensive approach to understanding taste perception and its implications for diet, nutrition, and aging.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114727"},"PeriodicalIF":2.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stair climbing interventions reduce postprandial hyperglycemia but not cognitive functions: findings of a randomized cross-over trial.","authors":"Eswaran Tpm Thirunavukarasu, Manaswi Reddy, Baskaran Chandrasekaran, Arun G Maiya, Chythra R Rao","doi":"10.1016/j.physbeh.2024.114726","DOIUrl":"https://doi.org/10.1016/j.physbeh.2024.114726","url":null,"abstract":"<p><p>Prolonged sitting can negatively impact postprandial glucose levels and cognitive functions. Stair climbing interventions have potential to mitigate these risks however remains unexplored. The present study aimed to explore the effects of stair climbing bouts on postprandial glucose and cognitive functions during prolonged sitting. Twenty-eight sedentary young adults (aged 20 - 30 years) underwent two intervention visits after standardized lunch for two hours: (1) STAIR: the participants climbed two flight of stairs for two minutes every 30 minutes; (2) SIT: the participants continued to sit. Blood glucose was measured using capillary finger prick method while attention function was measured using computer-based cognitive tests at baseline, end of 1st hour and 2nd hour. Significant interaction (F_{2, 54} = 15.96, p <0.001) was observed for conditions and time. During STAIR visit, significant changes in postprandial glucose at 1^st hour (β = - 2.6 mmol/dl, p <0.001) and 2^nd hour (β = 3.0 mmol/dl, p <0.001). No significant difference in the attention functions with time and conditions was observed. Stair climbing interruptions may be a promising solution to prevent high glycemic excursion occurring during prolonged sitting following postprandial sessions. However, the clinical benefits of stair climbing on attention functions remain unconvinced.</p>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":" ","pages":"114726"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}