Physiology & Behavior最新文献

{"title":"Initial adiposity is associated with body composition changes in response to diet-induced weight loss in normal-weight healthy individuals: The first results of the NUTRILEX study","authors":"Léna Pélissier ,&nbsp;Inès Ramos ,&nbsp;Bruno Pereira ,&nbsp;Yves Boirie ,&nbsp;Martine Duclos ,&nbsp;David Thivel ,&nbsp;Laurie Isacco","doi":"10.1016/j.physbeh.2025.114854","DOIUrl":"10.1016/j.physbeh.2025.114854","url":null,"abstract":"<div><div>While a significant number of normal-weight individuals are engaged in dieting practices, there is a need to better characterize the composition of weight change during and after weight loss (WL) intervention in this population. The study aimed to examine body composition in response to diet-induced WL and 4-month follow-up in normal-weight adults. Thirty-five participants (23 ± 4 y, 24 females) joined the laboratory to measure body weight (BW) and body composition using Dual-energy X-ray absorptiometry on 5 occasions: baseline (T0), 3 % WL (T1, <em>n</em> = 32), 6 % WL (T2, <em>n</em> = 18), 1-month follow-up (T3, <em>n</em> = 18), 4-month follow-up (T4, <em>n</em> = 16). BW, fat mass ([FM], kg and %), and lean body mass (LBM) decreased at T1 and T2 compared to T0 (<em>p</em> &lt; 0.01). While the participants with lower initial adiposity lost a lower proportion of FM at T1 and T2 (rho &lt; -0.45, <em>p</em> &lt; 0.05), the rate of WL and WL duration were not associated with changes in body composition. Participants declaring to stop the diet after the intervention significantly regained more BW and LBM, but not FM, from the end of the intervention to T3 (<em>p</em> &lt; 0.01) and T4 (<em>p</em> ≤ 0.01) compared to those who wanted to continue. To conclude, while both FM and LBM tissues were reduced in response to a diet-induced WL, only a major LBM regain was observed after 4 months of follow-up in participants who declared to not continue the diet at the end of the intervention.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114854"},"PeriodicalIF":2.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of D2-like dopamine receptors within the ventral tegmental area in the cannabidiol's inhibitory effects on the methamphetamine-seeking behavior","authors":"Mohammad Javad Ezzati ,&nbsp;Mohammad Reza Ezzati ,&nbsp;Mojdeh Fattahi ,&nbsp;Ronak Azizbeigi ,&nbsp;Abbas Haghparast","doi":"10.1016/j.physbeh.2025.114845","DOIUrl":"10.1016/j.physbeh.2025.114845","url":null,"abstract":"<div><div>Cannabidiol (CBD) is a non-psychoactive substance derived from marijuana. Although a comprehensive understanding of CBD's mechanism of action is still lacking, it is well-established that CBD can effectively mitigate the addictive properties associated with drugs. This study examined how CBD inhibits the acquisition and expression of methamphetamine-induced conditioned place preference (CPP) through D2-like dopamine receptors (D2R) in the ventral tegmental area (VTA). After recovery from surgery, animals were subjected to bilateral intra-VTA administration of different dosages (0.25, 1, and 4 μg/0.3 μl DMSO per side) of a selective D2R antagonist, sulpiride before intracerebroventricular (ICV) injection of CBD, during the conditioning phase (10 μg/5 μl DMSO) or once in the post-conditioning phase (50 μg/5 μl DMSO) of methamphetamine-induced CPP (daily subcutaneous injections of methamphetamine at 1 mg/kg over 5-day conditioning period). Findings revealed that CBD inhibits the acquisition and expression of methamphetamine reward memory. At the same time, microinjection of D2R antagonists into the VTA significantly reduced CBD's suppressive effect on the acquisition (0.25 μg; <em>P</em>&lt;0.05, 1 and 4 μg; <em>P</em>&lt;0.001) and expression (1 and 4 μg; <em>P</em>&lt;0.01) of methamphetamine place preference. Moreover, D2R blockage alone in the VTA did not affect the formation and expression of methamphetamine-induced CPP. In addition, the present study showed that administration of intra-VTA sulpiride and ICV injection of CBD together does not cause place preference in the CPP paradigm. In conclusion, pharmacological manipulation of D2Rs in the VTA may alter CBD's suppressive effects on the methamphetamine-context associations.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114845"},"PeriodicalIF":2.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference of LiCl-induced feeding suppression and, autonomic and HPA axis responses in crows","authors":"Chisato Yatsuda,&nbsp;Ei-Ichi Izawa","doi":"10.1016/j.physbeh.2025.114846","DOIUrl":"10.1016/j.physbeh.2025.114846","url":null,"abstract":"<div><div>Visceral sensation is crucial for feeding, emotion, and decision making in humans and non-human animals. Visceral discomforting stimulation activates stress-coping systems, such as the autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis, with varied responses and thresholds between sexes. Despite these systems working together during visceral discomfort, ANS and HPA have been separately investigated with few studies examining the co-occurrence of the ANS and HPA responses to visceral stimulations. The basic profiles of the ANS and HPA responses to visceral discomfort and sex differences in birds are poorly elucidated. This study investigated the effects of visceral stimulation via intraperitoneal injection of lithium chloride (LiCl) on feeding behavior, ANS and HPA activities, and sex differences in crows. We identified the LiCl dose that suppressed the intake of a preferred food and compared the LiCl-induced feeding suppression between sexes. Changes in heart rate variability (HRV), as a proxy of sympathetic and parasympathetic activities, and serum corticosterone (CORT) levels by LiCl injection were compared. Feeding suppression occurred at higher LiCl doses in males than in females. HRV analysis revealed that LiCl injection reduced HR and increased parasympathetic activity; however, it did not change sympathetic activity, with no sex differences in any variables. In contrast, LiCl injections at lower doses increased serum CORT levels more in males than in females. Our findings provide the first evidence of sex-specific response profiles to feeding suppression and ANS and HPA activities associated with LiCl-induced visceral discomfort in birds.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114846"},"PeriodicalIF":2.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of energy metabolism and muscular activity between sitting on a stability ball and office chairs: A pilot study","authors":"Hideaki Kumahara ,&nbsp;Miyuki Hirayama ,&nbsp;Naoko Goryozono ,&nbsp;Rina Morimoto ,&nbsp;Makoto Ayabe","doi":"10.1016/j.physbeh.2025.114841","DOIUrl":"10.1016/j.physbeh.2025.114841","url":null,"abstract":"<div><div>Stability balls (SB) are commonly used as substitutes for office chairs (OC) due to their potential benefits in preventing musculoskeletal issues. However, limited research has explored the specific impact of SB usage on energy expenditure (EE). This study investigated the effects of using various chairs, including SB, on energy metabolism, muscle activity, and subjective sensations during seated rest. Sixteen adults alternated randomly between four chair types, sitting on each for 10 min: OC with a backrest (OCcont), OC without a backrest, OC designed to promote proper posture, and SB. Expired gas and surface electromyogram (EMG) data were recorded. The integrated EMG (iEMG) was analyzed for two abdominal, two back, and two lower limb muscles. Oxygen consumption was significantly higher while sitting on SB (mean ± standard deviation, 13 ± 21 % net increase) compared to OCcont. The combined iEMG for all six muscles showed a notable increase while sitting on SB (54.9 ± 45.6 % net increase) versus OCcont, with rectus femoris activation being particularly prominent. These findings indicate that substituting a standard OC with an SB during office work induces small but significant physiological changes, potentially aiding in obesity and metabolic disorder prevention.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114841"},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of different intensities of treadmill exercise on food reward in young men","authors":"Yibin Li ,&nbsp;Miki Sakazaki ,&nbsp;Kayoko Kamemoto ,&nbsp;Chihiro Nagayama ,&nbsp;Masashi Miyashita","doi":"10.1016/j.physbeh.2025.114844","DOIUrl":"10.1016/j.physbeh.2025.114844","url":null,"abstract":"<div><div>Acute land-based high-intensity exercise has been shown to alter food reward. However, it remains unclear regarding the acute effect of different exercise intensities on food reward. Therefore, we examined the response of food reward to high- and low-intensity treadmill exercise in healthy young men. Twelve healthy young men (aged 22.8 ± 2.0 years, mean ± standard deviation) completed three, half-day laboratory-based trials (<em>i.e.,</em> high-intensity exercise, low-intensity exercise and control), in a random order. In the exercise trials, the participants performed a 60-min exercise (from 09:30 to 10:30) at a speed eliciting 70 % (high-intensity) or 40 % (low-intensity) of their maximum oxygen uptake and then rested for 90 min. In the control trial, participants sat on a chair for the entire trial (from 09:30 to 12:00). Food reward was measured at 09:20, 10:30 and 12:00. Relative preference for high-fat foods was not altered among the three trials. The relative preference for sweet foods was higher in the high-intensity exercise trial than the low-intensity exercise (mean difference: 15.3; 95 % CI: 2.53–28.14; <em>p</em> = 0.007) and control (mean difference: 14.6; 95 % CI: 2.37–26.80; <em>p</em> = 0.007) trials at 10:30 (<em>i.e.,</em> immediately after exercise). Greater relative preference for sweet relative to savoury foods was observed following an acute bout of high-intensity run. These findings suggest that high-intensity treadmill exercise may shift taste preference toward sweet foods in young healthy men.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114844"},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of estrogen on social recognition and oxytocin regulating synaptic plasticity","authors":"Tongtong Gao,&nbsp;Zhangxin Ying,&nbsp;Yani Yang,&nbsp;Xiaohong Xu","doi":"10.1016/j.physbeh.2025.114843","DOIUrl":"10.1016/j.physbeh.2025.114843","url":null,"abstract":"<div><div>Estrogens play an important role in the regulation of female social recognition; however, their mechanisms have not yet been elucidated. The present study established a mouse model of adolescent ovariectomy (Ovx) supplemented with a physiological dose of estradiol benzoate (EB, 10 µg/kg). Familiar-novel individual identification, urine odor discrimination, and social memory behaviors were assessed after adulthood. The results showed that Ovx-induced impairment of individual identification, urine odor discrimination, and social memory 24 h after testing were significantly improved by EB supplementation. Meanwhile, EB restored 17β-estradiol (17β-E₂) and oxytocin (OT) levels in the brain and serum of Ovx females. EB upregulated the expression level of OT receptor (OTR) protein and increased the numbers of ERα-ir and ERβ-ir cell in the medial amygdala (MeA). Electrophysiological studies further showed that OT (10 and 100 nM) promoted the induction and maintenance of long-term potentiation (LTP) in CA2 region of the hippocampal slices in vitro, which could be abolished by pretreatment with OTR antagonist l-368,899. 17β-E₂ (10 nM) not only promoted LTP, but also synergistically enhanced the promotion effect of 10 nM OT on LTP, which was eliminated by pretreatment with ERs antagonists ICI182780. These results suggest that estrogen promotes the OT system in the MeA and synergistically promotes OT increasing the synaptic plasticity of the hippocampus through ERs, which enhances social odor discrimination and social memory, and ultimately improves social recognition in female mice.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114843"},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian hormone effects on cognitive flexibility in social contexts: Evidence from resting-state and task-based fMRI","authors":"Jia-Xi Wang ,&nbsp;Lulu Fu ,&nbsp;Qin Lei ,&nbsp;Jin-Ying Zhuang","doi":"10.1016/j.physbeh.2025.114842","DOIUrl":"10.1016/j.physbeh.2025.114842","url":null,"abstract":"<div><div>Accumulating evidence suggests that the menstrual cycle and its endogenous ovarian hormones, including progesterone (PROG) and estradiol (E2), affect cognitive performance in women, particularly by modulating the prefrontal regions. In this study, we investigated whether differences in PROG and E2 levels modulate attentional control by affecting the prefrontal cognitive control areas. An fMRI scan was conducted on 53 naturally cycling healthy women in their late follicular phase (FP, n = 28) or mid-luteal phase (LP, n = 25) to examine the resting and task states during the completion of a face‒gender Stroop task. PROG was found to be positively correlated with the nodal efficiency of the inferior frontal gyrus (IFG) in the resting-state executive control network. At the behavioral level, while accuracy in categorizing male faces remained similar, participants in the mid-LP were significantly more accurate in categorizing female faces than those in the late FP. At the neural level, both the univariate and multivariate results indicated that higher levels of PROG enhance the detection and resolution of female incongruent faces through the activation of the bilateral IFG. These findings expand evidence of the effects of ovarian hormones on prefrontal-based attentional control in the social context.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114842"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of gut microbiota and bacterial translocation in the pathogenesis and management of type 2 diabetes mellitus: Mechanisms, impacts, and dietary therapeutic strategies","authors":"Ria Murugesan ,&nbsp;Janardanan Kumar ,&nbsp;Kakithakara Vajravelu Leela ,&nbsp;Sachdev Meenakshi ,&nbsp;Appandraj Srivijayan ,&nbsp;Shubhashree Thiruselvam ,&nbsp;Abhishek Satheesan ,&nbsp;Venkata Chaithanya","doi":"10.1016/j.physbeh.2025.114838","DOIUrl":"10.1016/j.physbeh.2025.114838","url":null,"abstract":"<div><h3>Purpose of Review</h3><div>The influence of gut microbiota on Type 2 Diabetes Mellitus (T2DM) is an emerging area of research. This review investigates the relationship between gut microbiota dysbiosis, bacterial translocation, and T2DM. It aims to elucidate how microbial imbalances contribute to the progression of T2DM through bacterial translocation and to evaluate dietary and therapeutic strategies to manage these effects.</div></div><div><h3>Recent Findings</h3><div>Recent studies highlight that dysbiosis in T2DM patients often leads to increased systemic inflammation, impaired glucose metabolism, and disrupted gut barrier integrity. These disruptions promote elevated levels of harmful bacterial components, such as lipopolysaccharides, in the bloodstream. This, in turn, is linked to worsening insulin resistance and metabolic dysfunction. Advances in molecular methods and biomarkers have provided deeper insights into bacterial translocation and its impact on diabetes. Dietary interventions, including nutraceutical agents, high-fiber and low-glycemic index diets, as well as the use of probiotics and prebiotics, have shown promise in restoring gut health and mitigating bacterial translocation.</div></div><div><h3>Conclusion</h3><div>Maintaining a balanced gut microbiota and intestinal barrier integrity is crucial for managing T2DM. Therapeutic strategies, including dietary modifications and nutraceuticals, have demonstrated potential in reducing bacterial translocation and systemic inflammation. Continued research is needed to refine these approaches and explore novel treatment modalities for improving metabolic health in T2DM patients.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114838"},"PeriodicalIF":2.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal microRNA-181a overexpression participates in anxiety and ethanol related behaviors via regulating the expression of SIRT-1","authors":"Amine Bahi","doi":"10.1016/j.physbeh.2025.114839","DOIUrl":"10.1016/j.physbeh.2025.114839","url":null,"abstract":"<div><div>Understanding the molecular mechanisms underlying anxiety and ethanol-related behaviors is crucial for developing effective therapeutic interventions. This study identifies a novel role for microRNA miR-181a and its target, Sirtuin 1 (SIRT-1), in the hippocampus as contributors to anxiety-like behavior and voluntary ethanol intake. Using male and female C57BL/6 mice, we explored the causal relationship between hippocampal miR-181a expression and these behaviors. Lentivirus vectors were delivered into the hippocampus for focal miR-181a overexpression in mice. Then behaviors were observed by elevated plus maze (EPM) and open field (OF) tests. Results showed that the viral approach employed to overexpress miR-181a, in the hippocampus, resulted in increased anxiety-like behavior in the EPM and OF tests. Additionally, miR-181a overexpression exacerbated voluntary ethanol intake and preference in the two-bottle choice paradigm without affecting saccharin or quinine consumption. Mechanistically, miR-181a gain-of-function reduced SIRT-1 expression in the hippocampus. These findings demonstrate that miR-181a upregulation in the hippocampus promotes anxiety and ethanol-related behaviors, likely through SIRT-1 repression. This work highlights miR-181a as a key molecular mediator in the epigenetic regulation of mood disorders and ethanol consumption.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114839"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated footshock stress enhances cocaine self-administration in male and female rats: Role of the cannabinoid receptor 1","authors":"Andrew D. Gaulden ,&nbsp;Erin A. Tepe ,&nbsp;Eleni Sia ,&nbsp;Sierra S. Rollins ,&nbsp;Jayme R. McReynolds","doi":"10.1016/j.physbeh.2025.114840","DOIUrl":"10.1016/j.physbeh.2025.114840","url":null,"abstract":"<div><div>Stress is a significant contributor to the development and progression of substance use disorders (SUDs) and is problematic as it is unavoidable in daily life. Therefore, it is important to understand the neurobiological mechanisms that underlie the influence of stress on drug use. We have previously developed a model of rat self-administration that employs an electric footshock stressor at the time of cocaine self-administration, resulting in an enhancement of cocaine self-administration. This stress enhancement of cocaine intake involves neurobiological mediators of stress and reward such as cannabinoid signaling. However, all of this work has been conducted in male rats. Here we test the hypothesis that repeated daily stress enhances cocaine self-administration in male and female rats. We further hypothesize that cannabinoid receptor 1 (CB1R) signaling is recruited by repeated stress to influence cocaine self-administration in both male and female rats. Male and female Sprague-Dawley rats self-administered cocaine (0.5 mg/kg/inf, i.v.) during a modified short-access paradigm wherein the 2 hr access was separated into four 30 min self-administration blocks separated by four 5 min drug free periods. Footshock stress significantly increased cocaine self-administration similarly in both male and female rats. Females displayed greater stress-enhanced time-out, non-reinforced responding, and stress-specific “front-loading” behavior. In males, systemic administration of a CB1R inverse agonist/antagonist Rimonabant only attenuated cocaine intake in rats with a history of combined repeated stress and cocaine self-administration. However, in females, Rimonabant attenuated cocaine self-administration in the no stress control group but only at the highest dose of Rimonabant (3 mg/kg, i.p.) suggesting that females show a greater sensitivity to CB1R antagonism. However, female rats with a history of stress showed even greater sensitivity to CB1R antagonism as both doses of Rimonabant (1, 3 mg/kg) attenuated cocaine self-administration in stress-enhanced rats, similar to males. Altogether these data demonstrate that stress can produce significant changes in cocaine self-administration and suggests that repeated stress at the time of cocaine self-administration recruits CB1Rs to regulate cocaine-taking behavior across sexes.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"293 ","pages":"Article 114840"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}