Hui Yang, Zhu Gui, Yunling Gao, Wenxiang Yu, Dexin Dang, Ning Zheng, Shaoyong Xu, Jie Wang
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引用次数: 0
Abstract
Adolescent chronic drinking has become increasingly prevalent worldwide, imposing significant physical and mental burdens in adulthood. However, the specific effects of different alcohol doses during adolescence on adult physiology remain incompletely understood. In this study, we established a 12-day chronic alcohol exposure model in adolescent rats using different alcohol doses. Behavioral tests, 13C nuclear magnetic resonance spectroscopy, and resting-state functional magnetic resonance imaging were then used to examine behavior, neurotransmitter metabolism, and brain functional connectivity in adulthood. We found that long-term low-dose alcohol exposure impairs hepatic metabolic function. In contrast, high-dose alcohol exposure not only induces hepatic metabolic disorders but also alters brain functional connectivity in adulthood and leads to anxiety-like behaviors.
期刊介绍：
Physiology & Behavior is aimed at the causal physiological mechanisms of behavior and its modulation by environmental factors. The journal invites original reports in the broad area of behavioral and cognitive neuroscience, in which at least one variable is physiological and the primary emphasis and theoretical context are behavioral. The range of subjects includes behavioral neuroendocrinology, psychoneuroimmunology, learning and memory, ingestion, social behavior, and studies related to the mechanisms of psychopathology. Contemporary reviews and theoretical articles are welcomed and the Editors invite such proposals from interested authors.
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