Physiology & Behavior最新文献_第8页

Are you willing to cooperate? The role of childhood adversities, family unpredictability and physiological self-regulation 你愿意合作吗？童年逆境、家庭不可预测性和生理自我调节的作用。

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2025-07-26 DOI: 10.1016/j.physbeh.2025.115041

Libera Ylenia Mastromatteo , Paolo Girardi , Sara Scrimin

{"title":"Are you willing to cooperate? The role of childhood adversities, family unpredictability and physiological self-regulation","authors":"Libera Ylenia Mastromatteo , Paolo Girardi , Sara Scrimin","doi":"10.1016/j.physbeh.2025.115041","DOIUrl":"10.1016/j.physbeh.2025.115041","url":null,"abstract":"<div><div>Cooperation is a universal phenomenon involving individuals working together to achieve a shared goal. Little attention has been given to how harsh environments in terms of childhood adversities and family unpredictability might be linked to individual’s engagement in cooperative behaviors and on how the persons’ physiological ability to adapt to the environment might influence this association. To fill this gap, we conducted two studies. The first showed in 1296 participants (44.44 % male, M<sub>age</sub> = 29.95, SD = 11.50) that adversities favor cooperation as individuals may strengthen bonds to alleviate the threats of environmental adversities, whereas family unpredictability hinders individuals’ willingness to cooperate as opting for certain non-cooperative gains when they are available is preferred over taking risks with uncertain cooperative outcomes.</div><div>The second showed in 88 undergraduate students (47.72 % male, M<sub>age</sub> = 23.67, SD = 4.91) showed the moderating role of individuals’ physiological self-regulation as indexed by cardiac vagal tone (CVT) in the previously found environment-cooperation link. Specifically, higher CVT promotes more consistent cooperative behaviors when facing higher levels of adversities, and lower CVT exacerbates the impact of both childhood adversities and family unpredictability reducing the probability of engaging in cooperative behaviors. Given the protective role of physiological regulation, when facing harsh childhood environments, interventions that strengthen this factor should be investigated in relation to prosocial behavior.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115041"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into shelter dog outcomes using behavioral and biological stress markers 利用行为和生物压力标记洞察收容所狗的结果

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2025-07-26 DOI: 10.1016/j.physbeh.2025.115040

Lauren Powell, Kathryn Graham, Laura Grant, Olivia Lenz, Chelsea L. Reinhard, Holly Yost, Elena Anderson, Brittany Watson

{"title":"Insights into shelter dog outcomes using behavioral and biological stress markers","authors":"Lauren Powell, Kathryn Graham, Laura Grant, Olivia Lenz, Chelsea L. Reinhard, Holly Yost, Elena Anderson, Brittany Watson","doi":"10.1016/j.physbeh.2025.115040","DOIUrl":"10.1016/j.physbeh.2025.115040","url":null,"abstract":"<div><div>Finding optimal tools to assess stress in animal shelters could protect welfare by identifying animals at risk of long stays and euthanasia. The goal of this observational study was to explore the utility of in-kennel behavior, fecal cortisol and immunoglobulin A (IgA) concentrations as indicators of shelter outcomes and length of stay. Between October 2023 and July 2024, 224 dogs were enrolled from three animal shelters in Pennsylvania. Fecal samples and behavioral videos were collected at two timepoints after shelter entry (0–48 h, 7–9 days), and analyzed using ELISAs and BORIS behavioral software, respectively. At shelter entry, canine behavior was largely associated with non-adoption outcomes. For instance, dogs who were returned to their owners showed increased panting (X<sup>2</sup>=13.38, <em>p</em> < 0.01), while euthanized and transferred dogs spent less time sitting than adopted dogs (X<sup>2</sup>=13.98, <em>p</em> < 0.01). For dogs who remained in the shelter at one week, shelter outcomes were largely associated with human-directed behaviors. Dogs who were adopted or transferred spent more time standing with their front paws on the cage (X<sup>2</sup>=7.95, <em>p</em> = 0.02) and wagging their tails than euthanized dogs (X<sup>2</sup>=6.66, <em>p</em> = 0.04). Adopted dogs had significantly higher cortisol concentrations than transferred dogs at baseline, but not at one week (<em>F</em>(2,78)=4.05<em>, p</em> <em>=</em> 0.02). IgA was not significantly related to shelter outcomes. Our findings suggest in-kennel behavioral observations may provide the most useful information for shelters to assess stress. Stress biomarkers did not offer definitive insights about shelter outcomes but highlighted a need for further research into adaptive coping styles in the shelter.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115040"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boldness associated with higher erythrocyte levels and a preference for higher temperatures can support the spread of European catfish to novel and warmer ecosystems 与较高的红细胞水平和对较高温度的偏好相关的大胆可以支持欧洲鲶鱼向新的和更温暖的生态系统的传播

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2025-07-25 DOI: 10.1016/j.physbeh.2025.115036

Nikola Kofentová , Ondřej Slavík , Josef Velíšek , Pavel Lepič , Tomáš Randák , Pavel Horký

{"title":"Boldness associated with higher erythrocyte levels and a preference for higher temperatures can support the spread of European catfish to novel and warmer ecosystems","authors":"Nikola Kofentová , Ondřej Slavík , Josef Velíšek , Pavel Lepič , Tomáš Randák , Pavel Horký","doi":"10.1016/j.physbeh.2025.115036","DOIUrl":"10.1016/j.physbeh.2025.115036","url":null,"abstract":"<div><div>Coping styles are the consistent physiological and behavioural responses of animals to stressors and, more generally, to variability in social and natural environments. Individuals can be characterized as proactive or reactive on the basis of their coping style, and their behavioural and physiological characteristics differ. Proactive, i.e., more bold, exploratory and stress-resistant individuals, spread more easily and prefer higher temperatures; however, available data regarding this natural stressor are available only from laboratory experiments. Indeed, data regarding the characteristics of invasive species in the wild are rare. In this study, we analysed the relationships among the boldness, exploratory behaviour, activity, physiological parameters, and temperature preferences of the European catfish, a large invasive species that destabilizes ecosystems outside its native environment. As expected, bold individuals presented greater erythrocyte counts, lower baseline cortisol levels, and increased exploratory behaviour. In a riverine environment, bold fish preferred warmer zones, reflecting their heightened metabolic demands and increased activity levels. Boldness, the number of erythrocytes and a preference for higher temperatures were key traits in both the field and experimental environments. However, the relationships among the parameters differed, suggesting behavioural adaptability to varying environmental conditions. In our study, the observed physiological and behavioural traits tended to increase the invasive potential of European catfish in warmer regions.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115036"},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The problem of large portion sizes: a norm-comparison theory explaining the psychological influence and public health implications of food portion size 大份量的问题：解释食物份量的心理影响和公共健康影响的标准比较理论

IF 2.5 3区医学

Physiology & Behavior Pub Date : 2025-07-25 DOI: 10.1016/j.physbeh.2025.115038

Eric Robinson , Ashleigh Haynes

{"title":"The problem of large portion sizes: a norm-comparison theory explaining the psychological influence and public health implications of food portion size","authors":"Eric Robinson , Ashleigh Haynes","doi":"10.1016/j.physbeh.2025.115038","DOIUrl":"10.1016/j.physbeh.2025.115038","url":null,"abstract":"<div><div>Portion size of food has a causal influence on human energy intake and historic increases in commercial food product portion sizes are suggested to have contributed to population-level obesity. A norm-comparison theory explains the influence of food portion size and suggests that increasing portion sizes are problematic for two reasons. First, this norm-comparison theory explains why changes to food portion size can have a sizeable influence on energy intake during a meal without inviting later compensatory eating behaviour. Second, because there is no objectively ‘correct’ portion size for any given food, exposure to larger portion sizes recalibrates perceptions of what a normal amount to eat is for any given food. Over time this process will have caused preferred portion sizes to shift upwards and contributed to increases in population level energy intake. However, a norm-comparison theory of food portion size also has implications for how to address the problem of excessively large portion sizes and guide public health measures to decrease population energy intake and body weight.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115038"},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of walnut oil on long-term memory of rats in a multiple-T-maze 核桃油对多重t型迷宫大鼠长期记忆的影响。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-07-18 DOI: 10.1016/j.physbeh.2025.115035

Matthias Nemeth, Thomas Jost, Eva Millesi, Carina Siutz

{"title":"Effects of walnut oil on long-term memory of rats in a multiple-T-maze","authors":"Matthias Nemeth, Thomas Jost, Eva Millesi, Carina Siutz","doi":"10.1016/j.physbeh.2025.115035","DOIUrl":"10.1016/j.physbeh.2025.115035","url":null,"abstract":"<div><div>Nutrition represents an important aspect regarding neuronal and cognitive functions. Especially the essential omega-3 polyunsaturated fatty acids (PUFAs) can positively affect cognitive abilities as indicated by various findings in humans and rodent models. Some important PUFA sources have been well investigated in this context while others received less attention, which also applies to walnut oil. Moreover, the majority of studies in rodents used similar types of mazes to assess learning and memory abilities and rarely investigated long-term memory abilities. For this pilot study, rats were supplemented with walnut oil for eight weeks (PUFA group) or received a control diet (control group) before they were trained to a three-choice multiple-T-maze task to test long-term memory abilities four weeks afterwards. In the end of the training phase as well as in the long-term memory test, no differences between diet groups were detected in the time to finish the task or the number of conducted errors. However, comparing the training phase and the memory test revealed an increase in the time and errors in the control group while the PUFA group remained constant in its performance. The findings presented here indicate that supplementation of walnut oil high in PUFAs can positively affect long-term memory formation in rats in a multiple-T-maze. Future studies may similarly consider alternative and more challenging maze tasks to assess the magnitude of cognitive influences.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115035"},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences distinguish performance in four object recognition-based memory tasks in the Pink1-/- rat model of Parkinson’s disease 在帕金森病的Pink1-/-大鼠模型中，性别差异区分了四种基于物体识别的记忆任务的表现。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-07-17 DOI: 10.1016/j.physbeh.2025.115034

Aveena M. Desai, Oluwagbohunmi A. Aje , Mary F. Kritzer

{"title":"Sex differences distinguish performance in four object recognition-based memory tasks in the Pink1-/- rat model of Parkinson’s disease","authors":"Aveena M. Desai, Oluwagbohunmi A. Aje , Mary F. Kritzer","doi":"10.1016/j.physbeh.2025.115034","DOIUrl":"10.1016/j.physbeh.2025.115034","url":null,"abstract":"<div><div>Male more than female patients with Parkinson’s disease (PD) experience early, sometimes prodromal non-motor deficits involving cognition and memory<strong>.</strong> These so-called mild impairments predict future risk of freezing, falls and developing PD-related dementia. Moreover, because most treatments are ineffective, these symptoms often persist and progressively worsen. Thus, there are urgent needs to better understand and better treat these signs. The work presented here highlights new ways in which rats with knockout of PTEN-induced putative kinase 1 gene (Pink1-/-) can serve as models that emulate PD’s mild cognitive deficits and their sex differences. Specifically, longitudinal behavioral testing confirmed that male Pink1-/- rats developed significant deficits in Novel Object Recognition and Novel Object Location tasks by 5 months old, but that female Pink1-/- were unimpaired in these and in the Object-in-Place task through testing at 12 months of age. Further, What, Where, When Episodic-like Memory testing showed that deficits in all three memory domains were present in Pink1-/- males by 3 months of age. However, in Pink1-/- females, non-significant episodic memory impairments were first observed at 7 months of age which progressed to significant deficits in ‘What’, ‘Where’ and ‘When’ domains by the time female rats were 12 months old. Together, these data show that Pink1-/- rats model the greater vulnerability of male PD patients to cognitive and memory deficits; the increasing risk for higher-order deficits in female PD patients with age; and other features including the early/earliest onset that distinguishes episodic memory impairments from other at-risk cognitive operations in this disorder.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115034"},"PeriodicalIF":2.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the estrogen withdrawal and chronic restraint stress and the maternal separation in mice postpartum depression modeling 雌激素戒断、慢性抑制应激及母亲分离对小鼠产后抑郁模型的影响。

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-07-16 DOI: 10.1016/j.physbeh.2025.115033

Jin Zhou , Zixin Wu , Zixuan Feng , Jing Li, Yazhou Wen, Ming Jiang, Shanwu Feng

{"title":"Comparison of the estrogen withdrawal and chronic restraint stress and the maternal separation in mice postpartum depression modeling","authors":"Jin Zhou , Zixin Wu , Zixuan Feng , Jing Li, Yazhou Wen, Ming Jiang, Shanwu Feng","doi":"10.1016/j.physbeh.2025.115033","DOIUrl":"10.1016/j.physbeh.2025.115033","url":null,"abstract":"<div><h3>Background</h3><div>Postpartum depression (PPD) is a severe psychological and psychiatric disorder that affects women during the perinatal period. Animal models play a crucial role in studying the pathogenesis of PPD. However, a comprehensive comparison of the distinctive features of estrogen withdrawal (EW), chronic restraint stress (CRS), and maternal separation (MS) rodent models, which are commonly used in PPD research, is lacking.</div></div><div><h3>Methods</h3><div>Three models of PPD were developed in this study, and the success of modeling was judged by the sucrose preference test (SPT) and the tail suspension test (TST). SPT, open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and TST were performed sequentially at the end of the molding process. Reproductive hormone changes in the peripheral blood, changes in GPR30 expression and GPR30<sup>+</sup> astrocytes in the hippocampus were also assessed.</div></div><div><h3>Results</h3><div>Data from the EW and CRS experiments showed a significant reduction in SPT and prolonging in the immobility time of the TST in subjects after modeling compared to baseline values. In all three models, levels of estradiol showed a significant decrease, whereas levels of progesterone statistically decreased and prolactin significantly increased only in the CRS and MS mice. Western-blot results showed a significant decrease in GPR30 expression in hippocampal regions of EW and CRS mice, while MS mice did not show differences. The EW and CRS models expressed less GPR30<sup>+</sup> astrocytes and the morphological complexity of astrocytes was significantly reduced in the hippocampal CA1 region.</div></div><div><h3>Conclusion</h3><div>The CRS model showed more obvious parameter changes and was closer to clinical PPD, which may be more appropriate to study PPD.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115033"},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of acute exergaming on short video-related inhibitory control: An event-related potential study 急性运动对短视频相关抑制控制的影响：一项事件相关电位研究

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-07-15 DOI: 10.1016/j.physbeh.2025.115032

Guolin Cheng, Biye Wang, Sunan Yu, Wei Guo

{"title":"The impact of acute exergaming on short video-related inhibitory control: An event-related potential study","authors":"Guolin Cheng, Biye Wang, Sunan Yu, Wei Guo","doi":"10.1016/j.physbeh.2025.115032","DOIUrl":"10.1016/j.physbeh.2025.115032","url":null,"abstract":"<div><div>This study aims to explore the impact of acute exergaming on short video-related inhibitory control, and to compare its effectiveness with that of a conventional aerobic exercise (cycling ergometer). In a between-subjects design, 87 participants were randomly assigned to one of three conditions: (1) exergaming, (2) cycling, or (3) control. Each participant engaged in 30 min of the assigned activity. Following the intervention, participants completed a Go/No-go task to measure their short video-related inhibitory control. Behavioral outcomes and event-related potential components were measured. The results showed that both acute exergaming and cycling enhanced the accuracy and P3 amplitudes for non-video app image stimuli (NVA). Acute exergaming specifically enhanced accuracy and P3 amplitudes for short-video app image stimuli (SVA), a pattern not observed following cycling. Latency analyses showed that exergaming and cycling resulted in shorter P3 latency than the control condition. In conclusion, while both interventions improved general inhibitory control, exergaming uniquely demonstrated enhancements in short video-related inhibitory control. These findings underscore the potential advantage of exergaming within its own contexts that benefit from higher cognitive, motivational, and multisensory engagement.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115032"},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 administration to Long–Evans rats has interactive effects with sex and diet on anxiety-related feeding behaviors and specific endocrine outcomes 长双歧杆菌R0175和helveticus乳杆菌R0052对Long-Evans大鼠的性别和饮食对焦虑相关摄食行为和特定内分泌结果的交互影响

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-07-13 DOI: 10.1016/j.physbeh.2025.115030

Elizabeth M. Myles , M. Elizabeth O’Leary , Isaac D. Romkey , Sara I. Hamm , Laura Dauphinee , Amanda Piano , Stéphane Bronner , Tara S. Perrot

{"title":"Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 administration to Long–Evans rats has interactive effects with sex and diet on anxiety-related feeding behaviors and specific endocrine outcomes","authors":"Elizabeth M. Myles , M. Elizabeth O’Leary , Isaac D. Romkey , Sara I. Hamm , Laura Dauphinee , Amanda Piano , Stéphane Bronner , Tara S. Perrot","doi":"10.1016/j.physbeh.2025.115030","DOIUrl":"10.1016/j.physbeh.2025.115030","url":null,"abstract":"<div><div>Anxiety symptomatology and metabolic functioning are intricately related, with associated mechanisms yet to be fully delineated. Nutritional manipulations may influence these outcomes in a sex-specific manner. This study characterized the interactive effects of the Cerebiome® probiotic and the D12079B-formulated Western diet (WD) on anxiety- and feeding-related behaviors and physiological outcomes in 80 male and female Long–Evans rats born to dams also administered either the probiotic or placebo during gestation and lactation. In WD-fed rats, the probiotic attenuated the increase in daily calorie intake observed in placebo rats. Subsequently, in the novelty-suppressed feeding task (NSFT), probiotic standard diet (SD) males spent more time in the center of an open field, suggesting a reduced anxiety-related state. Independent of diet and sex, probiotic administration resulted in more feeding bouts and food pellet contacts in the center compared to placebo. Furthermore, independent of probiotic and sex, WD rats lost less weight following the 24 h fast prior to behavioral testing and consumed more calories during the NSFT compared to SD rats. At sacrifice, rats given Cerebiome® had higher adrenal neuropeptide Y expression than placebo, and females had higher adrenal glucocorticoid receptor expression than males. In plasma, leptin was increased with WD and ghrelin was increased in SD females. These findings demonstrate that the Cerebiome® probiotic and this specific WD differentially affect behavioral and physiological indicators of health. We additionally demonstrate that concurrently administered nutritional factors interact to affect study outcomes based on sex, supporting the inclusion of both sexes in similar preclinical nutrition research.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115030"},"PeriodicalIF":2.4,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eating a high fat diet enhances sensitivity of rats to serotonin receptor agonists 高脂肪饮食能增强大鼠对血清素受体激动剂的敏感性

IF 2.4 3区医学

Physiology & Behavior Pub Date : 2025-07-13 DOI: 10.1016/j.physbeh.2025.115031

Nina M. Beltran , Jeremiah Ramos , Antonio Landavazo , Bruce E. Blough , Katherine M. Serafine

{"title":"Eating a high fat diet enhances sensitivity of rats to serotonin receptor agonists","authors":"Nina M. Beltran , Jeremiah Ramos , Antonio Landavazo , Bruce E. Blough , Katherine M. Serafine","doi":"10.1016/j.physbeh.2025.115031","DOIUrl":"10.1016/j.physbeh.2025.115031","url":null,"abstract":"<div><div>Rationale: Serotonergic medications are used for treating anxiety, depression, and obesity. Serotonin (5-HT) receptor agonists (e.g., 8-OH-DPAT, lorcaserin, and WAY 163909) induce unconditioned effects in rodents (e.g., lower lip retraction, flat body posture, penile erections, and forepaw treading), which can be used to measure drug sensitivity. Objective: The unconditioned effects of serotonergic drugs are hypothesized to be enhanced by eating a high fat diet. Methods: Male (<em>n</em> = 32) and female (<em>n</em> = 16) Sprague-Dawley rats eating high fat (60 % kcal from fat) or standard (17 % kcal from fat) laboratory chow were tested once weekly with cumulative doses of 5-HT receptor agonists (8-OH-DPAT [0.01–1.0 mg/kg, (subcutaneously, s.c.)], lorcaserin [1.0–32.0 mg/kg, (intraperitoneally, i.p.)], or WAY 163909 [1.0–32.0 mg/kg, i.p.] alone and in combination with antagonists selective for 5-HT<sub>1A</sub> (WAY 100635; 0.178 mg/kg, s.c.), or 5-HT<sub>2C</sub> (SB 242084; 1.0 mg/kg; i.p.) receptors. Results: 8-OH-DPAT induced lower lip retraction, flat body posture, and forepaw treading, while WAY 163909 and lorcaserin induced forepaw treading, penile erections, and weight loss. Rats eating high fat chow were more sensitive to 8-OH-DPAT-induced lower lip retraction and forepaw treading induced by 8-OH-DPAT, lorcaserin, and WAY 163909 as compared to rats eating standard chow. Lorcaserin and WAY 163909-induced penile erections were not different between rats eating high fat or standard chow. Forepaw treading, lower lip retraction, and flat body posture were attenuated by WAY 100635. In contrast, penile erections were attenuated by SB 242084. Conclusions: These results suggest that nutritional factors impact drug sensitivity in ways that might be relevant for the therapeutic effectiveness and side effect severity of serotonergic drugs.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115031"},"PeriodicalIF":2.4,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0