Physiology & Behavior最新文献

{"title":"The association between premenstrual symptom severity and eating disorder: Mediation by food addiction and emotional eating, moderation by irrational beliefs","authors":"Laurence J. Nolan ,&nbsp;Edna Aurelus ,&nbsp;Amy Eshleman","doi":"10.1016/j.physbeh.2025.115180","DOIUrl":"10.1016/j.physbeh.2025.115180","url":null,"abstract":"<div><div>Severe premenstrual symptoms (PS) have been linked to emotional eating (EE) and binge eating. The purpose of this study was to examine whether EE, dietary restraint, and/or food addiction (FA) mediated the relationship between PS and the odds of screening positive for an eating disorder. The role of irrational beliefs (IB), which can lead to dysfunctional emotional and/or behavioral responses, was examined as a potential moderator. 600 women (mean age = 26.6 ± 0.2 years) who had menstruated at least twice in the previous year completed online questionnaires. Methods to screen out automated (“bot”) responses were employed. Through purposive sampling, 25 % of the sample identified primarily as Asian, Black, Latina/Hispanic, White. No significant racial/ethnic identity differences were found for PS or any psychological measures. Results indicated that there was a positive relationship between PS and IB, depression, EE, external eating, dietary restraint, FA, and the odds of screening positive for an eating disorder. PS was weakly negatively associated with age but not with body mass index. EE and FA mediated the positive relationship between PS and the odds of having a positive screen for an eating disorder (controlling for depression). The association between PS and FA was stronger at higher levels of IB. IB also moderated the association between EE and the odds of having a positive screen for an eating disorder. Overall, the results indicate that those who have more severe PS engage in more uncontrolled eating in the form of EE and FA (particularly at higher IB levels for the latter) which are associated with higher odds of having a positive screen for an eating disorder.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115180"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of aerobic exercise on maternal lipid panel during the third trimester of pregnancy: A systematic review and meta-analysis of randomized controlled trials","authors":"Deivyd Vieira Silva Cavalcante ,&nbsp;Fernanda Valeriano Zamora ,&nbsp;Ayesha Ayesha ,&nbsp;Gabriel Gomes Lopes ,&nbsp;Noor Husain ,&nbsp;Beatriz Ximenes Mendes ,&nbsp;Ana Clara Felix de Farias Santos ,&nbsp;Luciane Betinelli ,&nbsp;Beatriz Cocato Malagutti ,&nbsp;Christian Ndikuryayo","doi":"10.1016/j.physbeh.2025.115170","DOIUrl":"10.1016/j.physbeh.2025.115170","url":null,"abstract":"<div><h3>Introduction</h3><div>It is known that Total cholesterol (TC) and Triglycerides (TG) levels can increase by up to 50 % during late pregnancy, conserving glucose and amino acids for the fetus while enabling the mother to derive energy from elevated lipids. However, the impact of aerobic exercise on lipid levels in non-dyslipidemic pregnant women remains unclear. To compare the effects of a structured aerobic exercise program versus usual physical activity on maternal lipid levels in pregnant women during their third trimester.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Embase, and Cochrane Central for ran- domised controlled trial(s) (RCT) comparing lipid profile TC, Low-density lipoprotein (LDL), High-density lipoprotein (HDL), and TG in pregnant women engaged in aerobic exercise versus those with usual physical activity. We employed the standardised mean difference (SMD) with a random-effects model to compare the post-intervention lipid pro- files. The level of heterogeneity was assessed using I² statistic. All statistical analyses were performed using RStudio 4.4.3.</div></div><div><h3>Results</h3><div>Eight studies were included in the analy- sis, encompassing 839 patients, of whom 44.69 % (<em>n</em> = 375) were assigned to the exercise group. The included patients were not dyslipidemia during the first trimester. Pregnant patients under a structured aerobic exercise program presented with a non-significant re- duction in TC levels (SMD 95 %CI:0.30—0.88; p00.28; <em>I</em>² = 0.32 %)86, LDL levels (SMD 95 %CI:0.08—0.51; p00.34; <em>I</em>² = 0.71 %)74, TG levels (-0.75 95 %CI:1.66–0.16; p00.11; <em>I</em>² = 91 %), and HDL levels (SMD 95 %CI:0.22—0.54; p00.09; <em>I</em>² = 0.16 %)58.</div></div><div><h3>Conclusion</h3><div>In non-dyslipidemic pregnant patients, a structured exercise program does not reduce lipid levels compared to usual physical activity, thereby maintaining the physiolog- ical advantages of the lipid increase observed in the third trimester.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115170"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAP-103, a multi-chemokine receptor antagonist, displays anxiolytic-like effects and normalizes methamphetamine abstinence-induced behaviors in planarians","authors":"Memunat Diekololaoluwa Abiru ,&nbsp;Sonita Wiah ,&nbsp;Meghana Dachepalli ,&nbsp;Amy D. Stringer ,&nbsp;Michael R. Ruff ,&nbsp;Scott M. Rawls","doi":"10.1016/j.physbeh.2025.115155","DOIUrl":"10.1016/j.physbeh.2025.115155","url":null,"abstract":"<div><div>RAP-103 is an orally active, multi-chemokine receptor antagonist (CRA) that inhibits three different chemokine receptors (CCR2, CCR5 and CCR8). Planarians, the simplest animals with bilateral symmetry and CNS cephalization, are useful for screening putative therapeutics because they express neurotransmitter systems and display mammalian-like behaviors when exposed to addictive drugs. We investigated effects of RAP-103 on spontaneous planarian behaviors (light avoidance, motility) and withdrawal responses associated with methamphetamine (METH) abstinence. Acute RAP-103 exposure decreased light avoidance (0.1, 1 μM) and increased motility (1 μM). For both endpoints, RAP-103 displayed an inverted U-shape concentration-effect curve. Maraviroc (1, 10 μM), a CCR5 antagonist, decreased light avoidance (like RAP-103) but reduced motility. RS 504393 (1, 10 μM), a CCR2 antagonist, increased light avoidance and reduced motility. For METH abstinence experiments, planarians were exposed for 5 min to a concentration of METH (1 μM) that did not cause spontaneous behaviors and then removed and placed into water. Planarians were then tested for light avoidance and motility during both early abstinence (0–5 min post-METH exposure) and later abstinence (15–20 min post-METH exposure). Light avoidance was enhanced during early METH abstinence whereas motility was reduced during later abstinence. RAP-103 (0.01, 0.1, 1 μM), administered during METH abstinence, counteracted METH-induced light avoidance but did not rescue METH-induced motility deficits. Our results with planarians show that RAP-103 displays anxiolytic-like and motor-enhancing effects and counteracts METH abstinence-induced behaviors, highlighting the potential of RAP-103 as a chemokine-based CNS therapeutic.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115155"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energetic costs related to isolation during dispersal in mole-rats, a laboratory approach","authors":"Jan Okrouhlík,&nbsp;Zuzana Vavrušková,&nbsp;Jiří Květoň,&nbsp;Radim Šumbera","doi":"10.1016/j.physbeh.2025.115169","DOIUrl":"10.1016/j.physbeh.2025.115169","url":null,"abstract":"<div><div>Although natal dispersal in the animal kingdom is an important phenomenon, it is very difficult to study, especially in animals with cryptic lifestyles. We studied the social aspect of dispersal by experimentally separating non-breeding adult giant mole-rats (<em>Fukomys mechowii)</em> from their natal families. Before and after separation, we estimated physiological and behavioural parameters related to energetics. After six weeks of separation animals had 25 % higher resting metabolic rate (RMR) at thermoneutral 30 °C, 35 % higher daily energy expenditure (DEE) at 30 °C and 22 % higher DEE at the thermally challenging 20 °C. Body mass, digging metabolic rate (DMR), digging speed and resting body temperature were unchanged However, post-digging temperature increase was 25 % lower, digging cost 10 % lower, and the DMR/RMR ratio 19 % lower than before separation. The increase in RMR in separated animals may be caused by changes in metabolic pathways and/or body composition. The higher DEE in separated animals at both T_as was probably caused by an increase in locomotor activity accompanied by elevated RMR. The smaller change in body temperature during digging in separated animals indicates a lower probability of overheating during this energy consuming activity while a lower digging cost in separated animals indicates that lone animals dig their tunnels more effectively. Overall, experimental social isolation, though not a full replication of natural dispersal, provides a practical means to study aspects of dispersal in mammals with extremely elusive way of life.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115169"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145506379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interactive effects of negative life events, cortisol reactivity, and gender on psychological distress among emerging adults","authors":"Li Shen Chong ,&nbsp;Teresa Mejia ,&nbsp;Kate L. Senich ,&nbsp;Christy L. Olezeski ,&nbsp;Elana B. Gordis","doi":"10.1016/j.physbeh.2025.115146","DOIUrl":"10.1016/j.physbeh.2025.115146","url":null,"abstract":"<div><div>Negative life events are associated with the development of psychological distress, including depression, anxiety, and traumatic stress symptoms. Evidence suggests that individual differences in stress response system activity may alter susceptibility to psychological distress for those with exposure to negative life events. In particular, women experience greater levels of psychological distress than men. Given that emerging adulthood is characterized by stressful, significant life transitions that may constitute risks for psychological distress, this study examined whether hypothalamic-pituitary-adrenal (HPA) axis activity and gender influenced the link between negative life events and psychological distress among emerging adults. Participants (<em>N</em> = 176; mean age = 19.03, 55 % women) self-reported negative life events during emerging adulthood and current depression, anxiety, and traumatic stress symptoms. HPA-axis activity was indexed by cortisol reactivity in response to a psychosocial stress task measured using the area under the curve with respect to ground (AUCg) and increase (AUCi). Regression analyses revealed a significant three-way interaction between negative life events, cortisol reactivity, and gender in predicting traumatic stress symptoms. Specifically, the association between negative life events and traumatic stress symptoms was stronger among women with lower levels of AUCg cortisol reactivity. Moreover, significant two-way interactions emerged between AUCi cortisol reactivity and gender in predicting depression, anxiety, and traumatic stress symptoms. Lower levels of cortisol reactivity were more strongly associated with higher levels of depression, anxiety, and traumatic stress symptoms only among women, but not among men. These findings highlight the importance of utilizing a biopsychosocial approach in understanding the development of psychological distress.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115146"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145479266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulsivity and antisocial behavior in sports: the moderating role of self-control","authors":"Congsheng Lu,&nbsp;Shi Bing","doi":"10.1016/j.physbeh.2025.115158","DOIUrl":"10.1016/j.physbeh.2025.115158","url":null,"abstract":"<div><div>Impulsivity, often defined as the propensity to act hastily without thoroughly weighing the consequences, is a recognized contributor to antisocial behavior. However, the mechanisms that might mitigate the influence of impulsivity on antisocial tendencies remain unclear. Across two studies, we tested the proposition that self-control moderates this relationship, such that high levels of self-control diminish the connection between impulsivity and antisocial behavior. Study 1, a cross-sectional analysis with 225 professional basketball players, and Study 2, a six-month longitudinal study with 349 professional athletes from various sports, provided evidence supporting this hypothesis. Specifically, the link between impulsivity and antisocial behavior was either negligible (Study 1) or significantly reduced (Study 2) in the presence of stronger self-control. The findings suggest the value of integrating self-control techniques in physical activity contexts to potentially curb antisocial behavior.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115158"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture promotes antidepressant effects by enhancing hippocampal neurogenesis via Wnt/β-catenin signaling in a chronic unpredictable mild stress-induced rat depression model","authors":"Zhuoran You ,&nbsp;Meng Li ,&nbsp;Jingyu Zeng ,&nbsp;Jianguo Li ,&nbsp;Simin Yan ,&nbsp;Muhammad Shahzad Aslam ,&nbsp;Junliang Shen ,&nbsp;Siyu Liu ,&nbsp;Jingxuan Li ,&nbsp;Hui Fang ,&nbsp;Lianlian Ning ,&nbsp;Yanglin Ruan ,&nbsp;Chongyao Hao ,&nbsp;Xianjun Meng","doi":"10.1016/j.physbeh.2025.115154","DOIUrl":"10.1016/j.physbeh.2025.115154","url":null,"abstract":"<div><h3>Background</h3><div>Acupuncture is a common complementary treatment for anxiety and depression. This study aimed to investigate whether acupuncture at <em>Shangxing</em> (GV23) and <em>Fengfu</em> (GV16) alleviates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors in rats, and to explore the underlying mechanisms involving the Wnt/β-catenin signaling pathway.</div></div><div><h3>Method</h3><div>Male Sprague-Dawley rats were randomly assigned to five experimental groups: control group (CON), model group (CUMS), fluoxetine group (CUMS + FLX), acupuncture group (CUMS + AP), and sham acupuncture group (CUMS + SAP). Behavioral evaluations of depression-like symptoms were conducted using the sucrose preference test (SPT), open field test (OFT), forced swimming test (FST), and elevated plus maze (EPM). Hippocampal morphology was assessed using hematoxylin–eosin (H&amp;E) and Nissl staining. Ki67 and doublecortin (DCX) expression were detected by immunofluorescence. Western blot (WB) and reverse transcription-polymerase chain reaction (RT-PCR) were conducted to quantify the expression levels of Wnt3a, glycogen synthase kinase 3β (GSK-3β), β-catenin in the hippocampus.</div></div><div><h3>Result</h3><div>Our findings indicated that CUMS induced depression-like behaviors, characterized by decreased sucrose preference, reduced locomotion and exploratory activity, less time spent in open arms, and prolonged immobility duration. Furthermore, compared to the CON group, the expression of Wnt3a, Dishevelled-2 (DVL2), β-catenin, the p-GSK-3β to GSK-3β ratio, positive cells of Ki67 and DCX were decreased but GSK-3β was increased in CUMS group. However, the detrimental effects were ameliorated by treatment with fluoxetine and acupuncture.</div></div><div><h3>Conclusion</h3><div>Acupuncture at GV23 and GV16 significantly improved depression in CUMS-induced rats by enhancing hippocampal neurogenesis and regulating the Wnt/β-catenin pathway.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115154"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising TRPV4 expression in the central nucleus of amygdala is involved in tooth movement pain","authors":"Rui Wang ,&nbsp;Dan Fang ,&nbsp;Yuxin Kang ,&nbsp;Weining Wang ,&nbsp;Yutong Guo ,&nbsp;Haiyang Kang ,&nbsp;Jinkun Fan ,&nbsp;Shuoshuo Yin ,&nbsp;Yuanzhan Deng ,&nbsp;Zhiping Hu ,&nbsp;Hu Qiao ,&nbsp;Shuang Wang","doi":"10.1016/j.physbeh.2025.115159","DOIUrl":"10.1016/j.physbeh.2025.115159","url":null,"abstract":"<div><div>Pain is the most common adverse effect of orthodontic treatment. Transient receptor potential vanilla-like protein 4 (TRPV4) plays an important role in pain regulation, and central amygdala (CeA) is also an important nuclear mass in pain regulation, but there is a paucity of literature on the roles of TRPV4 in CeA on tooth movement pain. C57BL/6 J mice were divided into control group, 0 g group and 30 g group. After establishing the experimental tooth movement model, behavioral tests were first performed, which showed that pain behavior peaked on day 1 and then dropped to baseline on day 7. The 30 g group developed anxiety-like behavior after 14 days of application, and the degree increased over time. In addition, immunofluorescence staining and western blot was performed on CeA tissues. The results showed that tooth movement significantly increased the fluorescence intensity of TRPV4 and protein expression of TRPV4, NLRP3, P65 and the phosphorylation of P65 proteins in CeA. Administration of TRPV4 antagonists in CeA through intraperitoneal injection effectively alleviated tooth movement induced pain and anxiety-like behaviors. This suggests that TRPV4 within CeA may mediate the regulation of tooth movement pain through NLRP3-NF-κB signaling pathway, which not only clarify the mechanism of CeA regulating tooth movement pain, but also help regulating tooth movement pain precisely.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115159"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145471653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memory deficits induced by a high-fat diet are reduced by HIIT and time-restricted feeding","authors":"Farzaneh Zeynali ,&nbsp;Maryam Delfan ,&nbsp;Ismail Laher ,&nbsp;Hassane Zouhal","doi":"10.1016/j.physbeh.2025.115145","DOIUrl":"10.1016/j.physbeh.2025.115145","url":null,"abstract":"<div><h3>Aim</h3><div>Consuming a high-fat diet (HFD) impairs memory function, and time-restricted feeding (TRF) and high-intensity interval training (HIIT) are potential interventions to prevent cognitive decline. However, the combined effects of TRF and HIIT on HFD-induced deficits in working and spatial memory remain unexplored.</div></div><div><h3>Materials and methods</h3><div>Thirty C57BL/6 male mice were divided into two groups: (1) normal chow (NC) (<em>n</em>= 6), (2) high-fat diet (HFD) (<em>n</em>= 24). The HFD groups were fed a 60 % HFD for 12 weeks, and then divided into four group: (1) control HFD (HFD), (2) HFD with HIIT training (HFD+HIIT), (3) HFD with TRF (HFD+TRF), (4) HFD with HIIT training and TRF (HFD+HIIT+TRF). The intervention groups underwent 8 weeks of HIIT (5 days per week), TRF (8/16 h) or a combination of HIIT and TRF. Behavioral tests of working and spatial memory were then conducted.</div></div><div><h3>Results</h3><div>Analysis by ANOVA revealed significant main effects of HIIT and TRF on working (HIIT: (F (1, 20) = 17.10, <em>p</em>= 0.0005, η² = 0.46; TRF: (F (1, 20) = 18.06, <em>p</em>= 0.0004, η² = 0.47) and spatial memory (HIIT: (F (1, 20) = 4.769, <em>p</em>= 0.04, η² = 0.19), TRF:(F (1, 20) = 11.80, <em>p</em>= 0.002, η² = 0.37)), while the interaction was not significant (working memory: F (1, 20) = 0.4722, <em>p</em>= 0.49, η² = 0.023; spatial memory: (F (1, 20) = 0.7888, <em>p</em>= 0.38, η² = 0.037)). Multiple comparisons indicated that the combined HIIT+TRF group outperformed both single-intervention groups, suggesting additive effects (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>HIIT and TRF independently improved HFD-induced memory deficits in male mice, with additive benefits in the combined group, highlighting the need for larger mechanistic studies to confirm these effects.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115145"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation of eating behaviour to reduced dietary protein intake in rats: influence of the amount of protein and amino acid composition in the diet","authors":"Tristan Dadillon ,&nbsp;Gaëlle Champeil-Potokar ,&nbsp;Marjorie Gourru,&nbsp;Nathalie Jérôme,&nbsp;Véronique Mathé,&nbsp;Morgane Dufay,&nbsp;Martin Chapelais,&nbsp;Juliane Calvez,&nbsp;Nicolas Darcel,&nbsp;Olivier Rampin,&nbsp;Olga Davidenko,&nbsp;Isabelle Denis","doi":"10.1016/j.physbeh.2025.115131","DOIUrl":"10.1016/j.physbeh.2025.115131","url":null,"abstract":"<div><div>Reducing meat consumption is encouraged to improve diet environmental sustainability. It results in reducing protein intake, and this can have consequences on eating behaviour. To better characterise these consequences, six-week-old male Wistar rats were divided into 5 groups receiving diets differing by their protein source and amount. Two groups received a casein (C) diet, containing 20% (C20) or 6% (C6) protein, a casein density known to induce a hyperphagic response in rats. Three groups received a dehydrated bovine protein (DBP) diet, containing 6% (B6), 10% (B10), or 20% (B20) protein. C20 and B20 rats had also free access to 40% protein pellets (casein for C20 and DBP for B20), but choose to maintain their protein intake close to 20%. C20 and B20 rats showed similar growth and food consumption throughout the 12-week experiment. B6 rats showed reduced growth (-26%) and lean body mass despite similar food consumption to B20. C6 and B10 rats increased their food intake (C6 by +20% relative to C20; B10 by +30% relative to B20) and showed similar growth to C20 and B20 rats. Comparison of amino acid intakes suggests that the amplitude of food overconsumption allowed C6 and B10 rats to achieve a threshold intake of specific essential amino acids. C6 and B10 rats had more visceral adiposity than C20 and B20 rats, but similar lean body mass. Our results characterize the hyperphagic response to moderate meat protein reduction, showing that it increases adiposity, then providing some insights into the obesogenic risk potentially associated with reduced meat consumption.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"304 ","pages":"Article 115131"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}