Physiology & Behavior最新文献

{"title":"Acupuncture waggle needling alleviates spastic movement disorder in post-stroke rats via GLT-1 activation to modulate Glu/GABA-Gln cycle","authors":"Zhou Zhang ,&nbsp;Liang-Xiao Ma ,&nbsp;Jie-Dan Mu ,&nbsp;Meng-Yu Chen ,&nbsp;Xu Qian ,&nbsp;Qin-Yong Zhang ,&nbsp;Ling-Hui Ma","doi":"10.1016/j.physbeh.2025.115059","DOIUrl":"10.1016/j.physbeh.2025.115059","url":null,"abstract":"<div><div>Post-stroke spastic movement disorder (PS-SMD) significantly hinder the rehabilitation of stroke survivors, and evidence suggests that acupuncture yields favorable efficacy for this condition. However, the precise mechanisms of acupuncture effects remain elusive. Hence, this study aims to elucidate the potential mechanisms of a classic motion-style acupuncture method, waggle needling, in alleviating PS-SMD via the lens of the Glu/GABA-Gln cycle. Firstly, multiple behavioral assessments including neurologic function scale, muscle tone scale, open field test, balance beam test, and gait analysis, and electrophysiological test were utilized, to investigate acupuncture’s effects on middle cerebral artery occlusion (MCAO) rat model with spastic motor impairment. Then, ELISA, Western blotting, RT-qPCR, and immunofluorescence were used to illustrate the expression alterations of the key proteins in the Glu/GABA-Gln cycle. Lastly, pharmacological interventions using GLT-1 inhibitor and agonist were performed to investigate their impacts on acupuncture’s effects. We found that acupuncture alleviated neural damage and muscle spasticity, enhanced autonomous locomotion, motor balance and gait symmetry, and alleviated spinal hyperreflexia in PS-SMD rats. These effects were associated with the enhanced expressions of GLT-1, GAD65/67, GS, and VGAT in the ischemic cortical motor area, leading to the restoration of the Glu/GABA balance. Acupuncture-induced effects were partially attenuated by GLT-1 inhibitor, whereas GLT-1 agonist partially recapitulated these effects. Our results demonstrate that acupuncture waggle needling may improve motor behaviors and alleviate spinal hyperreflexia of PS-SMD rats by modulating the Glu/GABA-Gln cycle via GLT-1 to facilitate the restoration of the Glu/GABA equilibrium.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"301 ","pages":"Article 115059"},"PeriodicalIF":2.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of EP-1 exposure during lactation on the emotion, social behavior, gonadal metabolomics, and related receptors in the brains of adult offspring in Kunming mice","authors":"Chendong Wu,&nbsp;Miao Cheng,&nbsp;Jie Zhang,&nbsp;Xiang Ji,&nbsp;Peng Chen,&nbsp;Peng Yu","doi":"10.1016/j.physbeh.2025.115057","DOIUrl":"10.1016/j.physbeh.2025.115057","url":null,"abstract":"<div><div>Infertility control with EP-1 (quinestrol: levonorgestrel = 1:2) has proven effective in a variety of rodents. Previous studies have focused on the effects of EP-1 in terms of sterility; however, little is known about its cross-generational impact. In this study, the emotional and social behavior, gonadal metabolomics, serum hormone levels, and related brain receptors in adult offspring were examined following exposure to EP-1 (3 or 5 mg/kg), which was administered to dams 3 and 10 days postnatally by gavage. The results showed that EP-1 exposure enhanced anxiety-like behavior in males and diminished social behavior in both females and males. EP-1 exposure reduced the levels of <em><span>l</span>-glutamine</em> and <em><span>l</span>-glutamic acid</em> in the ovaries and those of <em><span>l</span>-glutamine, L‑serine</em>, and <em><span>l</span>-phenylalanine</em> in the testes, possibly resulting in metabolic abnormality and decreased estradiol and testosterone levels in serum. Furthermore, EP-1 exposure increased the expression of dopamine 1 receptor (D1R) in the nucleus accumbens (NAc), estrogen receptor α (ERα) and oxytocin receptor (OTR) in the medial preoptic area (MPOA), and that of ERα in the ventrolateral region of ventromedial hypothalami of females; contrastingly, it decreased the expression of vesicular GABA transporter in the medial amygdala while increasing that of D1R in the NAc and that of ERα and OTR in the MPOA of individual males. In conclusion, EP-1 exposure during lactation enhanced anxiety-like behavior in males, reduced sociality, affected gonadal function, reduced sex hormone levels, and altered the relative expression of receptors in the brain regions that regulate social behaviors in all offspring mice.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"301 ","pages":"Article 115057"},"PeriodicalIF":2.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status","authors":"María F. Andreoli ,&nbsp;Pablo N. De Francesco ,&nbsp;Olga E. Titova ,&nbsp;Mario Perello ,&nbsp;Helgi B. Schiöth","doi":"10.1016/j.physbeh.2025.115049","DOIUrl":"10.1016/j.physbeh.2025.115049","url":null,"abstract":"<div><h3>Background</h3><div>The putative role of LEAP2 in central nervous system functions such as attentional or cognitive processes related to food intake remain poorly understood in humans.</div></div><div><h3>Aims</h3><div>To investigate the relationship between fasting LEAP2 concentration and attentional or cognitive processes related to food cues, and whether body weight status may modulate them.</div></div><div><h3>Methods</h3><div>Stroop-Food and Stroop Low-Calorie/High-Calorie food tasks, Attention-Network-Test, Iowa-Gambling-Task, and fasting LEAP2 concentration were assessed in 108 men aged 18–40 yr with normal weight (NW) and 91 with overweight or obesity (OW/OB). Multivariable linear regression analyses were conducted to examine the relationship between fasting LEAP2 concentration and behavioral tests outcomes.</div></div><div><h3>Results</h3><div>Individuals with OW/OB exhibited lower number of correctly identified words in the Stroop Food and Stroop Low-Calorie/High-Calorie Food tasks and had higher LEAP2 concentrations compared to NW participants (<em>p</em> &lt; 0.01). Fasting LEAP2 was positively associated with Executive attention [Beta (95 % CI): 21.18 (2.91, 39.45), <em>p</em> = 0.024], and inversely with Alerting attention [Beta (95 % CI):18.04 (-35.52, -0.57), <em>p</em> = 0.043], in NW but not in subjects with OW/OB. LEAP2 was positively related with responses to low-calorie food words [Beta (95 % CI): 11.88 (0.52, 23.25), <em>p</em> = 0.041] only in subjects with OW/OB.</div></div><div><h3>Conclusion</h3><div>LEAP2 is associated with attention and cognitive responses in men depending on body weight status. It may play a differential role in cognitive processes related to food intake, particularly in individuals with OW/OB while influencing attentional processes in lean subjects.</div></div><div><h3>Clinical Trial Registry</h3><div>This study was registered at clinicaltrials.gov as NCT01863212. <span><span>https://clinicaltrials.gov/study/NCT01863212</span><svg><path></path></svg></span></div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"301 ","pages":"Article 115049"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gustatory function and cognitive impairment in the Korean elderly","authors":"Young Goh ,&nbsp;Jung-Ho Yang ,&nbsp;Sun-Seog Kweon ,&nbsp;Min-Ho Shin ,&nbsp;Jeong-Hwa Choi","doi":"10.1016/j.physbeh.2025.115047","DOIUrl":"10.1016/j.physbeh.2025.115047","url":null,"abstract":"<div><div>A decline in chemosensing is commonly observed in the aging process including neurodegenerative disease, however studies regarding taste sensitivity and cognitive impairment are in lacked. This study examined whether cognitive impairment is associated with gustatory dysfunction in elderly Koreans. A total of 310 Koreans from Korean Genome and Epidemiology Study - Cardiovascular Disease Association Study were analyzed to assess their cognitive function and gustatory function. The participants’ cognitive level was classified into three categories: normal, mild cognitive impairment (MCI), and dementia, using the Korean version of the mini mental state examination-second edition: standard version. To evaluate gustatory function, the participants were tested with five tastants: sweet, bitter, salty, sour, and umami, using the whole-mouth technique. A total of 44 subjects (14.2 %) were defined for MCI, and 29 subjects (9.4 %) were defined for dementia. There was no significant association found between the distribution of gustatory dysfunction (10 %) and cognitive impairment. However, subjects with dementia had significantly lower detection sensitivity for sourness compared to those with normal cognition and MCI. While no significant association was observed between cognitive impairment and overall gustatory dysfunction, dementia was associated with a decline in sensitivity to sourness, compared to individuals with normal cognition and those with MCI. The reduced sensitivity to sourness may serve as a potential screening marker for cognitive decline, warranting further research in this area.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"302 ","pages":"Article 115047"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-psychoactive cannabis extract promotes extinction and reduces reinstatement by priming dose in smoked cocaine-induced conditioned place preference","authors":"Fabián Leonardo Barreto,&nbsp;María Constanza Lozano,&nbsp;Jorge A. Martínez-Ramírez","doi":"10.1016/j.physbeh.2025.115048","DOIUrl":"10.1016/j.physbeh.2025.115048","url":null,"abstract":"<div><div>The therapeutic potential of Cannabis sativa L. and cannabidiol (CBD) for substance use disorders is being actively investigated using murine addiction models. However, the efficacy of cannabis or its constituents in attenuating dependence indicators associated with smoked cocaine consumption remains unclear. This study employed a Conditioned Place Preference (CPP) paradigm using anhydroecgonine methyl ester and cocaine (AEME-COC) as the reinforcing agent to model smoked cocaine consumption in mice. The model was utilized to evaluate the preclinical efficacy of a non-psychoactive cannabis extract (NPCE) and CBD on extinction parameters and reinstatement induced by stress and priming doses. Experiment 1 compared conditioning phase (Cond) and extinction times between subjects administered cocaine and those receiving AEME-COC. Experiment 2 investigated the effects of CBD and NPCE on extinction latency in AEME-COC-induced CPP. Experiment 3 examined the competitive 5-HT1A receptor antagonist WAY-100,135 and CB2 receptor inverse agonist AM630 on NPCE-mediated inhibition of stress-induced and priming-induced reinstatement of AEME-COC-induced CPP. The results showed that subjects administered cocaine exhibited greater exploration of the conditioned compartment during Cond compared to those administered AEME-COC, with the latter group displaying prolonged extinction latency (Experiment 1). NPCE, but not CBD, significantly reduced the extinction latency of AEME-COC-induced CPP (Experiment 2). In Experiment 3, NPCE selectively inhibited priming-induced reinstatement but did not affect stress-induced reinstatement. The 5-HT1A receptor attenuated NPCE’s inhibitory effects on priming-induced reinstatement, whereas the CB2 receptor had no significant modulatory impact on this indicator. These findings suggest that NPCE influences smoked cocaine dependence indicators primarily through serotonergic receptor modulation.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"301 ","pages":"Article 115048"},"PeriodicalIF":2.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory recognition and transduction mechanism in Small-tailed Han Sheep","authors":"Xiyi Hu ,&nbsp;Jiguang Wang ,&nbsp;Hui Wang ,&nbsp;Fukuan Li ,&nbsp;Zhennan Wang ,&nbsp;Yan Yang ,&nbsp;Shenjin Lv ,&nbsp;Mingfa Sun","doi":"10.1016/j.physbeh.2025.115046","DOIUrl":"10.1016/j.physbeh.2025.115046","url":null,"abstract":"<div><div>In mammals, the olfactory system is essential for detecting odors and inducing responses associated with social behaviors, attraction, aversion, and fear. While the behavioral responses of sheep to predator stimuli have been intensively studied, knowledge regarding olfactory processing remains limited. In this study, we used leopard feces as a predator stimulus to explore the mechanisms involved in olfactory transduction in sheep. We found that exposure to leopard feces decreased the frequency of foraging and walking, as well as the duration of walking behavior. Furthermore, total cholesterol and globulin levels significantly increased after exposure. Subsequent RNA sequencing analysis of main olfactory epithelium (MOE) and olfactory bulb (OB) tissues identified 545 significantly differentially expressed unigenes in the MOE (217 upregulated, 328 downregulated) and 1506 in the OB (723 upregulated, 783 downregulated) when comparing leopard feces-stimulated and control groups. Subsequent Kyoto Encyclopedia of Genes and Genomes analysis of these unigenes indicated that they were mostly enriched in the cAMP signaling pathway in the MOE and ECM-receptor interaction and dopaminergic synapse pathways in the OB. These results offer new insights into how predator odor stimulation influences olfactory processing in sheep and expand our knowledge of the mechanisms underlying olfactory transduction and signal generation. Collectively, our findings provide comprehensive genomic insights into olfactory perception and anti-predator defence mechanisms in domestic sheep (<em>Ovis aries</em>).</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"301 ","pages":"Article 115046"},"PeriodicalIF":2.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of body awareness, perceived stress level, postural awareness and habits and musculoskeletal pain in people living with overweight and obesity: A comparative study","authors":"Aziz Dengiz ,&nbsp;Fatma Nur Altin","doi":"10.1016/j.physbeh.2025.115043","DOIUrl":"10.1016/j.physbeh.2025.115043","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a major global health concern associated with physical and psychological risks. These factors may influence body awareness, stress, posture, and pain. This study aimed to examine body awareness, perceived stress level, postural awareness and habits, and musculoskeletal pain in people living with obesity (PLWO).</div></div><div><h3>Methods</h3><div>This study was conducted with 397 participants aged 18–65 years, categorized into normal-weight (mean: 21.44 ± 4.78 (N:130 ( %32.7)) overweight (mean: 27.44 ± 1.37 (N:118 ( %29.72 and PLWO (mean: 33.99 ± 3.47 (N:149 ( %37.53)) groups. Data were collected online using structured questionnaires. Body awareness was assessed with the Body Awareness Questionnaire, postural awareness with the Postural Habits and Awareness Scale, and stress levels with the Perceived Stress Questionnaire. Anxiety and depression were measured using the Hospital Anxiety and Depression Scale, while pain and sleep quality were evaluated with Visual Analogue Scale. Group differences were analyzed using One-Way ANOVA. Hochberg’s GT2 or Games-Howell tests were used for post hoc comparisons based on variance homogeneity. Statistical significance was set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Significant differences were found in body awareness scores among groups (<em>F</em> = 4.544, <em>p</em> = 0.011), with healthy-weight people scoring higher (87.05 ± 17.22) than overweight (81.65 ± 18.48) and PLWO (81.42 ± 15.96). Perceived stress levels were significantly elevated in overweight (41.55 ± 8.97) and PLWO group (44.44 ± 7.65) compared to healthy-weight people (26.66 ± 6.00) (<em>p</em> &lt; 0.001). Musculoskeletal pain and sleep disturbances were also significantly more frequent in overweight and PLWO. Healthy-weight people demonstrated greater postural (11.70 ± 1.71) and positional awareness (38.7 ± 5.0), while PLWO scored higher in postural habits (15.77 ± 3.07).</div></div><div><h3>Conclusion</h3><div>People living with obesity showed impaired body and positional awareness alongside increased stress and maladaptive postural habits, which may contribute to functional limitations. Targeted interventions enhancing body awareness and stress management are therefore essential to address these deficits.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"301 ","pages":"Article 115043"},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of constant, intermittent, and dynamic lighting on human alertness and circadian rhythms: A controlled study across multiple daytime exposure blocks on college students","authors":"Jingqiang Li,&nbsp;Xiaotong Yin,&nbsp;Huanxi Zhang,&nbsp;Xuemeng Zhang","doi":"10.1016/j.physbeh.2025.115044","DOIUrl":"10.1016/j.physbeh.2025.115044","url":null,"abstract":"<div><div>Preventing fatigue and improving alertness are crucial for ensuring worker safety. Light exposure affects alertness, circadian rhythms, and behavioral performance. Although several recent studies have investigated these effects, their results have been inconsistent. This study determined optimal indoor lighting conditions by conducting a three-factor mixed crossover experiment to assess the daytime alertness of 147 college student participants (mean age: 20.82 ± 0.87 years) over a 16-h period under different lighting modes (constant, intermittent, and dynamic), lighting exposure time blocks (6:30–8:30, 8:30–10:30, 13:30–15:30, 17:30–19:30, and 19:30–21:30), and test times. Subjective sleepiness, melatonin concentration, core body temperature, and attentional performance were measured for each participant. Among the college student group, dynamic lighting had a markedly greater positive effect on alertness, circadian rhythms, and performance than constant lighting. In addition, intermittent lighting had a more substantial impact on core body temperature than constant or dynamic lighting. However, intermittent and dynamic lighting did not significantly differ in their effects on subjective alertness, melatonin secretion, or attentional performance. Furthermore, the positive effects of lighting on various indicators were most pronounced at 6:30–8:30, 8:30–10:30, and 19:30–21:30. The results confirmed that the effects of lighting on alertness and circadian rhythms were more significant during the morning and evening than at other times and that dynamic lighting had a more substantial effect than constant or no lighting. The study results offer a theoretical basis for human-centered indoor lighting design, thereby improving worker alertness and reducing incidents involving unsafe conditions.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115044"},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor impairments and increased GFAP expression in different stages of a progressive model of parkinsonism induced by reserpine","authors":"Edson R. Santos ,&nbsp;Thassya F.O. Santos ,&nbsp;José M.M. Bispo ,&nbsp;Milena C.N.M. Carvalho ,&nbsp;João E.C. Melo ,&nbsp;Mylaine S. Mendonça ,&nbsp;Katty A.A.L. Medeiros ,&nbsp;Alessandra M. Ribeiro ,&nbsp;Regina H. Silva ,&nbsp;Marco Aurelio M. Freire ,&nbsp;Auderlan M. Gois ,&nbsp;José R. Santos","doi":"10.1016/j.physbeh.2025.115042","DOIUrl":"10.1016/j.physbeh.2025.115042","url":null,"abstract":"<div><div>Neuroinflammation plays a pivotal role in the progression of Parkinson’s disease, involving the activation of microglia and astrocytes. Astrocytes are essential for the development and maintenance of neural tissue, but can shift to a pro-inflammatory phenotype in response to factors such as oxidative stress and excitotoxicity. Here, we aimed to evaluate the astroglial response in a rodent model of parkinsonism induced by chronic low-dose reserpine administration. Adult male Wistar rats received reserpine (0.1 mg/kg, i.p.) every other day for 30 days (RES group), while control animals (CTL group) received the same number of vehicle injections. Motor impairment was assessed via catalepsy and tape tests after the 4th, 8th, 12th, and 15th injections. Subsets of animals were perfused 48 h after the 4th, 10th, and 15th injections for immunohistochemical analysis of glial fibrillary acidic protein (GFAP) and tyrosine hydroxylase (TH). We found increased GFAP⁺ cell density in the dorsal striatum at all time points, indicating early astrocyte activation. However, reductions in astrocytic arborization after the 10th and 15th injections suggested a phenotypic shift toward a reactive, pro-inflammatory state. Concurrently, TH⁺ cell counts declined in the <em>substantia nigra pars compacta</em> after the 10th and 15th injections, and in the ventral tegmental area after the 15th, paralleling the onset of motor deficits. Behavioral tests showed increased latency to movement from the 4th injection onward, suggesting that initial astrocyte activation may confer neuroprotection, which wanes as reserpine-induced tissue damage progresses.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115042"},"PeriodicalIF":2.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing link among phase angle, muscle strength, body composition variables, and urine metabolites in Japanese females with or without dysmenorrhea: A pilot study","authors":"Suraiya Khatun ,&nbsp;Akiko Uchizawa ,&nbsp;Emi Kondo ,&nbsp;Katsuhiko Yajima ,&nbsp;Analiza M Silva ,&nbsp;Daisuke Hoshi ,&nbsp;Yoshiaki Tanaka ,&nbsp;Naoki Mukai ,&nbsp;Koichi Watanabe ,&nbsp;Naomi Omi ,&nbsp;Kiyoji Tanaka ,&nbsp;Hiroyuki Sagayama","doi":"10.1016/j.physbeh.2025.115039","DOIUrl":"10.1016/j.physbeh.2025.115039","url":null,"abstract":"<div><h3>Background</h3><div>Dysmenorrhea, characterized by painful menstruation, can influence body composition, muscle strength, and metabolic function. This study aimed to investigate differences and relationships between body composition variables, phase angle (PhA), muscle strength, and urine metabolites among Japanese female individuals with and without dysmenorrhea.</div></div><div><h3>Methods</h3><div>Thirty-four participants, divided into healthy menstruating control (<em>n</em> = 15) and dysmenorrhea (<em>n</em> = 19) groups, were included. PhA, whole body lean soft tissue (WB LST), visceral fat (VF) and subcutaneous fat (SF), hand grip strength (HGS), leg strength, and urine metabolites were measured using multifrequency bioelectrical impedance analysis, dual-energy X-ray absorptiometry, computed tomography, dynamometry, and liquid chromatography, respectively.</div></div><div><h3>Results</h3><div>No significant differences were found in the characteristic variables. BMI, PhA, and muscle strength showed a positive association only in the control group. However, menstrual status (control/dysmenorrhea, 0/1) did not affect muscle strength. Conversely, a negative coefficient (LASSO: -0.098; Elastic net: -0.109) demonstrated that the dysmenorrhea group had lower predictive PhA values than did the control group. PhA and WB LST were identified as meaningful predictors of HGS (R² = 0.433) and leg strength (R² = 0.251). Acylcarnitine metabolites were positively associated with VF and PhA in the dysmenorrhea and control groups, respectively.</div></div><div><h3>Conclusion</h3><div>The study findings highlight distinct associations among body composition, PhA, muscle strength, and urinary metabolites in these female groups. However, the study is limited by the absence of severity of dysmenorrhea symptoms, phases of menstruation, and no adjustment for lifestyle factors. A future longitudinal study is warranted to understand these physiological association between the control and dysmenorrhea groups.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"300 ","pages":"Article 115039"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}