The influence of ovarian activity and menopause on mental health: Evidence from animal models and women

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior Pub Date : 2025-03-19 DOI:10.1016/j.physbeh.2025.114886

Ediana V. Neitzke , Fabiola G. dos Santos , Bianka M. Zanini , Marcelo B. Cavalcante , Jeffrey B. Mason , Michal M. Masternak , Izabel C.C. de Souza , Augusto Schneider

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引用次数: 0

Abstract

Hormonal variations occurring throughout the female reproductive cycle have a significant impact on physical and mental health, particularly due to the influence of estradiol (E2) and progesterone (P4). These changes are directly related to alterations in neurological systems, being associated with conditions such as premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and mood disorders during hormonal transition phases, such as perimenopause and menopause. Studies conducted in humans and animal models indicate that these fluctuations affect neurotransmitters, neural plasticity, and patterns of brain activity, ultimately influencing quality of life and mental health. Despite extensive research on the topic, the interactions between sex hormones, mental health, and reproductive aging still require further investigation, emphasizing approaches that simultaneously address experimental and behavioral aspects. Thus, this review aims to sumarize findings about the influence of hormonal fluctuations throughout the female reproductive lifespan, including transitions such as perimenopause and menopause, on mental health. A comparative analysis of data from studies in animal models and humans was conducted, highlighting neuroendocrine, behavioral, and emotional mechanisms associated with hormonal changes and their impacts on female mental health.

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卵巢活动和更年期对心理健康的影响：来自动物模型和妇女的证据。

在整个女性生殖周期中发生的激素变化对身心健康产生重大影响，特别是由于雌二醇（E2）和黄体酮的影响（P4）。这些变化与神经系统的改变直接相关，与经前综合征（PMS）、经前焦虑症（PMDD）以及激素过渡阶段（如围绝经期和绝经期）的情绪障碍等疾病有关。在人类和动物模型中进行的研究表明，这些波动影响神经递质、神经可塑性和大脑活动模式，最终影响生活质量和心理健康。尽管对这一主题进行了广泛的研究，但性激素、心理健康和生殖衰老之间的相互作用仍需要进一步调查，强调同时解决实验和行为方面的方法。因此，本综述旨在总结在整个女性生殖周期中，包括围绝经期和绝经期等过渡时期荷尔蒙波动对心理健康影响的研究结果。对动物模型和人类研究的数据进行了比较分析，强调了与激素变化相关的神经内分泌、行为和情绪机制及其对女性心理健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology & Behavior 医学-行为科学

CiteScore

5.70

自引率

3.40%

发文量

274

审稿时长

47 days

期刊介绍： Physiology & Behavior is aimed at the causal physiological mechanisms of behavior and its modulation by environmental factors. The journal invites original reports in the broad area of behavioral and cognitive neuroscience, in which at least one variable is physiological and the primary emphasis and theoretical context are behavioral. The range of subjects includes behavioral neuroendocrinology, psychoneuroimmunology, learning and memory, ingestion, social behavior, and studies related to the mechanisms of psychopathology. Contemporary reviews and theoretical articles are welcomed and the Editors invite such proposals from interested authors.