Phytochemistry最新文献

{"title":"C-glycosylated and alkylated flavonoids with potent anti-inflammatory activity from the whole plants of Drymaria cordata","authors":"Lan-Yi Lu ,&nbsp;Yan-Hua Wu ,&nbsp;Peng Zhang ,&nbsp;Li-Yan Wang","doi":"10.1016/j.phytochem.2025.114624","DOIUrl":"10.1016/j.phytochem.2025.114624","url":null,"abstract":"<div><div><em>Drymaria cordata</em> is a traditional Chinese medicinal plant used for the treatment of hepatitis and chronic nephritis. Six previously undescribed flavonoid C-glycosides (<strong>1</strong>–<strong>3</strong>, <strong>8</strong>, <strong>9</strong>, <strong>11</strong>), two unreported alkylated flavonoids (<strong>4</strong>, <strong>5</strong>), and four known flavonoids (<strong>6</strong>, <strong>7</strong>, <strong>10</strong>, <strong>12</strong>) were isolated from its 70 % ethanol extract. The structures were established by extensive analysis of NMR, HRMS, and X-ray single-crystal diffraction. All compounds exhibited inhibitory activity against nitric oxide production, with compound <strong>8</strong>, which contains a rare sugar moiety (3,5-dihydroxy-6-methyl-<em>γ</em>-pyrone), showing the most pronounced effect. Further investigation revealed that <strong>8</strong> suppressed the expression of several key cytokines and inhibited the phosphorylation of <em>p</em>65. Molecular docking studies indicated that <strong>8</strong> targeted IKK, an upstream regulator of the NF-κB pathway, thereby blocking its activation.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"240 ","pages":"Article 114624"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation and evaluation of the antioxidant activity of Cornus sanguinea","authors":"Annunziata Paolillo ,&nbsp;Antonietta Cerulli ,&nbsp;Roberta Cuozzo ,&nbsp;Francesco Sottile ,&nbsp;Francesco Montella ,&nbsp;Elena Ciaglia ,&nbsp;Sonia Piacente ,&nbsp;Milena Masullo","doi":"10.1016/j.phytochem.2025.114622","DOIUrl":"10.1016/j.phytochem.2025.114622","url":null,"abstract":"<div><div><em>Cornus sanguinea</em> L. (common dogwood) is a small tree with leaves showing a characteristic dark red colour in senescence. <em>C. sanguinea</em> is traditionally used for several diseases. The drupes are used as a remedy for diarrhea, stomachaches, sore eyes, sore throats, and gastrointestinal disorders, and the dried roots are used as a febrifuge. With the aim to further define the chemistry of <em>C. sanguinea</em> and to validate its biological activities, the methanol extract of the whole plant was investigated. The total phenolic content and the total flavonoid content of <em>C. sanguinea</em> extract were evaluated along with the antioxidant activity by TEAC and DPPH assays. To determine the <em>in vitro</em> antioxidant activity, ROS inhibition analysis was performed by DHR assay on HaCat keratinocytes cell line pre-treated with the extract. The extract displayed statistically significant activity in the range 32–125 μg/mL in the HaCat cell line stimulated with 2 mM H₂O₂. The chemical profile of the extract was investigated by an initial LC-MS analysis that guided the identification and isolation of 25 compounds, of which the structures were unambiguously elucidated by NMR analysis and LC-MS analysis as phenolic acids, flavonoids, megastigmanes, and benzofuran. This study yielded four previously unreported compounds: one megastigmane derivative and three phenolic acids. Additionally, two oxylipins were tentatively identified by LC-MS.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"240 ","pages":"Article 114622"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory cyclopropanes and benzofurans from mangrove endophytic fungus Schizophyllum sp. QYM-12","authors":"Tao Chen ,&nbsp;Bing Sun ,&nbsp;Xingze Hu ,&nbsp;Yanghui Ou ,&nbsp;Jianying Wu ,&nbsp;Tingshun Zhu ,&nbsp;Hongliang Yao ,&nbsp;Zhigang She","doi":"10.1016/j.phytochem.2025.114611","DOIUrl":"10.1016/j.phytochem.2025.114611","url":null,"abstract":"<div><div>Ten undescribed metabolites, including seven cyclopropane derivatives (<strong>1</strong>−<strong>7</strong>) and three benzofuran derivatives (<strong>11</strong>−<strong>13</strong>), along with three known cyclopropane analogues (<strong>8</strong>−<strong>10</strong>) were isolated from the mangrove endophytic fungus <em>Schizophyllum</em> sp. QYM-12. Their planar structures were established through mass spectrometric and extensive spectroscopic data. The absolute configurations of all compounds were determined by the modified Mosher's method, electronic circular dichroism calculations, ¹³C NMR calculations and DP4+ analysis. In the bioassay, compounds <strong>6</strong> and <strong>9</strong> exhibited IL-6 inhibitory activities with IC₅₀ values of 34.5 and 25.4 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"240 ","pages":"Article 114611"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyano-containing Daphniphyllum alkaloids with antienteroviral activity from the leaves and stems of Daphniphyllum calycinum Benth","authors":"Peishan Gu ,&nbsp;Yang Jin ,&nbsp;Shujie Jia ,&nbsp;Xiao-Nian Li ,&nbsp;Yue Liu ,&nbsp;Yanheng Zhou ,&nbsp;Meixin Chen ,&nbsp;Yongbo Xue","doi":"10.1016/j.phytochem.2025.114610","DOIUrl":"10.1016/j.phytochem.2025.114610","url":null,"abstract":"<div><div>Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease (HFMD), is often associated with severe clinical outcomes. In this study, three rare cyano-containing alkaloids, cyanodaphcalycines A–C (<strong>1</strong>–<strong>3</strong>), featuring an unusual 5/6/6/7/5/5-hexacyclic scaffold, and an undescribed daphmanidin A-type alkaloid, daphmanidin G (<strong>4</strong>), were isolated from the leaves and stems of the medicinal plant <em>Daphniphyllum calycinum</em> Benth., along with three known <em>Daphniphyllum</em> alkaloids (<strong>5</strong>–<strong>7</strong>). The previously undescribed structures and their absolute configurations were determined using a combination of spectroscopic analysis, a single crystal X-ray diffraction analysis, and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. In the biological evaluation, the antiviral activities of compounds <strong>1</strong>–<strong>4</strong> were tested against EV71 in human malignant embryonal rhabdomyosarcoma (RD) cells. Compounds <strong>3</strong> and <strong>4</strong> exhibited potent antiviral effects against human EV71 in RD cells, with EC₅₀ values of 3.78 ± 0.23 and 6.87 ± 0.30 μg/mL, respectively, demonstrating superior efficacy to ribavirin (EC₅₀ 65.77 ± 0.11 μg/mL). This is the first report of <em>Daphniphyllum</em> alkaloids as potent inhibitors of EV71.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114610"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesquiterpenoids from Achillea setacea Waldst. & Kit. with anti-inflammatory activity by inhibiting the glycolytic pathway","authors":"Gui-Min Xue ,&nbsp;Jin-Feng Xue ,&nbsp;Jiang-Jing Duan ,&nbsp;Hui-Ying Yang ,&nbsp;Yan-Jun Sun ,&nbsp;Hui Chen ,&nbsp;Yan-Le Zhi ,&nbsp;Zhi-Qiang Zhang ,&nbsp;Rao Li ,&nbsp;Dong-Rong Zhu ,&nbsp;Guo-Sheng Li","doi":"10.1016/j.phytochem.2025.114608","DOIUrl":"10.1016/j.phytochem.2025.114608","url":null,"abstract":"<div><div>Six previously undescribed sesquiterpenoids, named achisetaces A–F (<strong>1</strong>–<strong>6</strong>), involving a rare C₆–<em>O</em>–C₁₀ bridged guaianolide-type sesquiterpenoid (<strong>1</strong>), along with nine known analogues (<strong>7</strong>–<strong>15</strong>), were obtained from the aerial parts of <em>Achillea setacea</em> Waldst. &amp; Kit. The undescribed structures of <strong>1</strong>–<strong>6</strong> including their absolute configurations were determined through spectroscopic techniques (IR, UV, HRESIMS, 1D and 2D NMR), combined with DP4+ NMR analysis and quantum electronic circular dichroism (ECD) calculations. The inhibitory effects of compounds <strong>1</strong>–<strong>15</strong> on nitric oxide (NO) production were evaluated in LPS-induced RAW 264.7 cells. Compounds <strong>6</strong> and <strong>10</strong> exhibited significant anti-inflammatory activities with IC₅₀ values of 1.56 ± 0.32 and 6.89 ± 0.47 μM, respectively. Moreover, a mechanistic study revealed that compound <strong>6</strong> exerted the anti-inflammatory activity by regulating the glycolytic pathway <em>via</em> suppression of PFKFB3 activation.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114608"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iridoids and other constituents from the aerial parts of Patrinia rupestris and their inhibitory effects on nitric oxide production","authors":"Zhi-Yuan Liu ,&nbsp;Sheng-Run Guo ,&nbsp;Jian-Xian Tang,&nbsp;Chun-Yan Zhao,&nbsp;Li Pu,&nbsp;Li-Zhong Wang,&nbsp;Dan Liu,&nbsp;Rong-Tao Li,&nbsp;Hong-Mei Li","doi":"10.1016/j.phytochem.2025.114609","DOIUrl":"10.1016/j.phytochem.2025.114609","url":null,"abstract":"<div><div>Forty-three compounds, including nine undescribed compounds, five iridoids (patrirupesins A−E, <strong>1</strong>−<strong>5</strong>) and four bis-iridoids (patrirupesins F–I, <strong>6</strong>−<strong>9</strong>), were isolated from the EtOAc-soluble fraction of the aerial parts of <em>Patrinia rupestris</em> (Pall.) Dufr., and their structures were elucidated based on Mass spectrometry and NMR spectroscopy. The absolute configuration of patrirupesins A−E (<strong>1</strong>−<strong>5</strong>) and I (<strong>9</strong>) was determined by experimental and calculated electronic circular dichroism (ECD). In addition, patrirupesin E (<strong>5</strong>), patrirupesin H (<strong>8</strong>), 8,9-didehydro-7-hydroxydolichodial (<strong>17</strong>), 5,6-epoxy-3-hydroxy-7-megastigmen-9-one (<strong>19</strong>), <em>iso</em>-seco-tanapartholide (<strong>24</strong>) and 3-hydroxy-2-methyl-4-(3-oxoprop-1-en-2-yl)cyclopent-1-enecarbaldehyde (<strong>43</strong>) showed <em>in vitro</em> anti-inflammatory activity on NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) with IC₅₀ values of 9.32 ± 3.83, 4.63 ± 1.23, 8.31 ± 4.05, 17.23 ± 5.19, 8.30 ± 6.17 and 27.38 ± 4.69 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114609"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromosome-level genome of Nardostachys jatamansi and comparative genomics analysis reveals its sesquiterpenoid biosynthesis","authors":"Xuexue Li ,&nbsp;Yuan Liu ,&nbsp;Xuan Liu ,&nbsp;Huachun Sheng ,&nbsp;Juan Li ,&nbsp;Wenbing Li ,&nbsp;Ying Li ,&nbsp;Chen Chen ,&nbsp;Jingqiu Feng ,&nbsp;Xinjia Yan ,&nbsp;Zhengming Yang ,&nbsp;Yanfei Huang ,&nbsp;Zhifeng Zhang ,&nbsp;Shaoshan Zhang","doi":"10.1016/j.phytochem.2025.114607","DOIUrl":"10.1016/j.phytochem.2025.114607","url":null,"abstract":"<div><div><em>Nardostachys jatamansi</em> (D. Don) DC., an aromatic and medicinal herb belonging to the <em>Nardostachys</em> genus within the Caprifoliaceae family, is globally well-known for its attractive perfume and health-promoting properties. However, genomic information specific to <em>N. jatamansi</em> remains largely unexplored. In this study, the first <em>de novo</em> assembly of the <em>N. jatamansi</em> genome was presented which spans approximately 2.88 Gb with the contig N50 of 9.92 Mb and scaffold N50 of 40.09 Mb. Using Hi-C sequencing data, we successfully anchored 98.53 % of the assembled sequences into 78 pseudochromosomes (6n = 13), a result corroborated by chromosome (cytogenetic) analysis. The genome comprises 92.33 % repeat sequences, including 73.82 % TEs and 18.51 % tandem repeats, as well as a total of 174,054 protein-coding genes, of which 93.62 % have been functionally annotated in databases such as NR, GO, KEGG, Interpro, and others. In addition, our analysis identified 4144 tRNAs, 7537 rRNAs, 707 miRNAs, and 3400 snRNAs within the genome. Comparative genomics revealed that <em>N</em>. <em>jatamansi</em> exhibited high genetic redundancy. Phylogenetic analysis supports the current knowledge that the new APG IV classification system places <em>N</em>. <em>jatamansi</em> within the Caprifoliaceae family. Genes from the most expanded gene families, especially the TPS gene cluster at the end of chromosome 3A, are likely involved in the biosynthesis of sesquiterpenoids in <em>N. jatamansi</em>. Hopefully, our work would provide a valuable basis for revealing natural product-related biosynthetic pathways in <em>N. jatamansi</em> and advancing evolutionary studies within the Caprifoliaceae family.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114607"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial activity and mechanism of polyketides from the marine-derived fungus Talaromyces sp.","authors":"Ruiyun Huo ,&nbsp;Guangrong Zi ,&nbsp;Dongxiao Shi ,&nbsp;Ying Shi ,&nbsp;Jinwei Ren ,&nbsp;Kui Hong ,&nbsp;Ling Liu","doi":"10.1016/j.phytochem.2025.114606","DOIUrl":"10.1016/j.phytochem.2025.114606","url":null,"abstract":"<div><div>Six previously undescribed natural products, talaromenes A−D (<strong>1</strong>−<strong>4</strong>), prugosene F (<strong>5</strong>), and prugosene G (<strong>6</strong>), as well as four previously known compounds (<strong>7</strong>−<strong>10</strong>), were isolated and characterized from the culture of the marine-derived fungus <em>Talaromyces</em> sp. WHUF04072. The structures of these compounds were determined by the HRESIMS and NMR spectroscopic data. The absolute configurations of the unreported compounds were determined by ECD calculations and ECD experiments induced by Rh₂(OCOCF₃)₄. Moreover, all isolated compounds were evaluated for their antibacterial activities. Compound <strong>8</strong> exhibit significant antibacterial activities against several strains of <em>Staphylococcus aureus</em> with MICs ranging from 0.125 to 0.25 μg/mL. Additionally, it can effectively inhibit the biofilms formation of methicillin-resistant <em>S. aureus</em> (MRSA). Further mechanism studies revealed that <strong>8</strong> could exhibited significant antibacterial effects against MRSA by disrupting bacterial membranes. These results suggested that <strong>8</strong> may be developed into a new antibacterial candidate for combating MRSA infections.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114606"},"PeriodicalIF":3.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam of Professor Marie-Aleth Lacaille-Dubois 1950–2025","authors":"Anne-Claire Mitaine-Offer","doi":"10.1016/j.phytochem.2025.114593","DOIUrl":"10.1016/j.phytochem.2025.114593","url":null,"abstract":"","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114593"},"PeriodicalIF":3.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dammarane triterpenoids with anti-inflammatory and promoting glucose uptake activities from the leaves of Cyclocarya paliurus","authors":"Xiaoqin Liang ,&nbsp;Qingfang Zheng ,&nbsp;Biqun Zou ,&nbsp;Yanqin Li ,&nbsp;Liwei Pan ,&nbsp;Chenyang Ren ,&nbsp;Jiwen Xin ,&nbsp;Bo Yang ,&nbsp;Ruiyun Yang ,&nbsp;Weifeng Xu ,&nbsp;Chaowen He ,&nbsp;Yanling Cui ,&nbsp;Wen Tang ,&nbsp;Ruijie He ,&nbsp;Jun Li","doi":"10.1016/j.phytochem.2025.114605","DOIUrl":"10.1016/j.phytochem.2025.114605","url":null,"abstract":"<div><div>Fourteen triterpenoids, namely eight undescribed dammarane triterpenoid saponins (<strong>1</strong>–<strong>8</strong>, named cypaliurusides S–Z₇) and six known analogues (<strong>9</strong>–<strong>14</strong>), were isolated from the leaves of <em>Cyclocarya paliurus</em>. The undescribed compounds exhibited diverse side-chain modifications, including conjugated double bonds, multiple hydroxyl groups and a five-member oxygen ring formed via 20,24-diol dehydration. Their structures were elucidated through comprehensive nuclear magnetic resonance (NMR) (1D/2D) and high-resolution electrospray ionisation mass spectrometry data analysis, with absolute configurations determined by dimolybdenum tetraacetate induced <strong>circular dichroism</strong> spectra and <strong>density functional theory gauge-independent atomic orbital</strong> ¹³C-NMR calculation. <strong>Bioactivity evaluation</strong> revealed that cypaliurusides T (<strong>2</strong>) and U (<strong>3</strong>) exhibited <strong>potent</strong> anti-inflammatory activity [<strong>half-maximal inhibitory concentration (</strong>IC₅₀) = 7.6 and 8.1 μM, respectively], surpassing that of the positive control dexamethasone (IC₅₀ = 9.2 μM). Additionally, cypaliurusides S (<strong>1</strong>), T (<strong>2</strong>), U (<strong>3</strong>), X (<strong>5</strong>) and Y (<strong>6</strong>) <strong>showed a dose-dependent enhancement</strong> of insulin-stimulated glucose uptake in 3T3-L1 adipocytes at concentrations of 2.5–10 μM. Structure–activity relationship analysis indicated that C-24/C-25 dihydroxylation is critical for anti-inflammatory activity, while the C-25 hydroxyl group is essential for enhancing glucose uptake. These findings may contribute to the discovery of antidiabetic agents.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114605"},"PeriodicalIF":3.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}