Iridoids and other constituents from the aerial parts of Patrinia rupestris and their inhibitory effects on nitric oxide production

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-07-01 DOI:10.1016/j.phytochem.2025.114609

Zhi-Yuan Liu , Sheng-Run Guo , Jian-Xian Tang, Chun-Yan Zhao, Li Pu, Li-Zhong Wang, Dan Liu, Rong-Tao Li, Hong-Mei Li

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引用次数: 0

Abstract

Forty-three compounds, including nine undescribed compounds, five iridoids (patrirupesins A−E, 1−5) and four bis-iridoids (patrirupesins F–I, 6−9), were isolated from the EtOAc-soluble fraction of the aerial parts of Patrinia rupestris (Pall.) Dufr., and their structures were elucidated based on Mass spectrometry and NMR spectroscopy. The absolute configuration of patrirupesins A−E (1−5) and I (9) was determined by experimental and calculated electronic circular dichroism (ECD). In addition, patrirupesin E (5), patrirupesin H (8), 8,9-didehydro-7-hydroxydolichodial (17), 5,6-epoxy-3-hydroxy-7-megastigmen-9-one (19), iso-seco-tanapartholide (24) and 3-hydroxy-2-methyl-4-(3-oxoprop-1-en-2-yl)cyclopent-1-enecarbaldehyde (43) showed in vitro anti-inflammatory activity on NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) with IC₅₀ values of 9.32 ± 3.83, 4.63 ± 1.23, 8.31 ± 4.05, 17.23 ± 5.19, 8.30 ± 6.17 and 27.38 ± 4.69 μM, respectively.

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红花地上部环烯醚萜及其对一氧化氮产生的抑制作用。

从芦花柏属（Patrinia rupestris, Pall）地上部乙酸乙酯可溶部分中分离得到43个化合物，包括9个未描述化合物，5个环烯醚萜（patrirupesins A-E, 1-5）和4个双环烯醚萜（patrirupesins F-I, 6-9）。Dufr。，并通过质谱和核磁共振对其结构进行了分析。通过实验和计算的电子圆二色性（ECD）确定了帕氏菌素A-E（1-5）和I(9)的绝对构型。此外,patrirupesin E (5), patrirupesin H(8), 8日9-didehydro-7-hydroxydolichodial(17), 5、6-epoxy-3-hydroxy-7-megastigmen-9-one (19), iso-seco-tanapartholide(24)和3-hydroxy-2-methyl-4 - (3-oxoprop-1-en-2-yl) cyclopent-1-enecarbaldehyde(43)体外抗炎活动没有生产264.7原始细胞刺激由脂多糖(LPS) IC50值为9.32±3.83、4.63±1.23、8.31±4.05、17.23±5.19、8.30±6.17、27.38±4.69μM,分别。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.