红树林内生真菌Schizophyllum sp. qymm -12的抗炎环丙烷和苯并呋喃。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-07-10 DOI:10.1016/j.phytochem.2025.114611

Tao Chen , Bing Sun , Xingze Hu , Yanghui Ou , Jianying Wu , Tingshun Zhu , Hongliang Yao , Zhigang She

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引用次数: 0

摘要

从红树林内生真菌Schizophyllum sp. qymm -12中分离到10个未描述的代谢物，包括7个环丙烷衍生物（1-7）和3个苯并呋喃衍生物（11-13），以及3个已知的环丙烷类似物（8-10）。通过质谱和大量的光谱数据确定了它们的平面结构。通过改进的Mosher法、电子圆二色性计算、13C核磁共振计算和DP4+分析确定了所有化合物的绝对构型。化合物6和9的IC50值分别为34.5 μM和25.4 μM，具有抑制IL-6的活性。

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Anti-inflammatory cyclopropanes and benzofurans from mangrove endophytic fungus Schizophyllum sp. QYM-12

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Anti-inflammatory cyclopropanes and benzofurans from mangrove endophytic fungus Schizophyllum sp. QYM-12

Ten undescribed metabolites, including seven cyclopropane derivatives (1−7) and three benzofuran derivatives (11−13), along with three known cyclopropane analogues (8−10) were isolated from the mangrove endophytic fungus Schizophyllum sp. QYM-12. Their planar structures were established through mass spectrometric and extensive spectroscopic data. The absolute configurations of all compounds were determined by the modified Mosher's method, electronic circular dichroism calculations, ¹³C NMR calculations and DP4+ analysis. In the bioassay, compounds 6 and 9 exhibited IL-6 inhibitory activities with IC₅₀ values of 34.5 and 25.4 μM, respectively.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.