Photochemistry and Photobiology最新文献

{"title":"Photodynamic therapy of cancer-associated infections.","authors":"Giulia Kassab, Juan Chen, Gang Zheng","doi":"10.1111/php.14038","DOIUrl":"10.1111/php.14038","url":null,"abstract":"<p><p>Pathogens can be involved in tumor initiation, promotion, and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor-prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections and, therefore, has a unique potential to address their combination. However, we believe this potential has been underutilized, and few researchers have investigated the impacts of PDT of both infection-related and cancer-related outcomes at once. This review presents the main agents behind cancer-associated infections (CAIs), the PDT protocols that have been tested on them, and their key findings. Additionally, we discuss the key aspects of PDT that make it ideal for CAI treatment, and what knowledge gaps need to be filled in order to make it successful.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"833-845"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bright and long-lasting aqueous peroxyoxalate chemiluminescence in cellulose microspheres.","authors":"Maidileyvis C Cabello, Erick L Bastos, Omar A A El Seoud, Wilhelm J Baader","doi":"10.1111/php.14040","DOIUrl":"10.1111/php.14040","url":null,"abstract":"<p><p>Water decreases the brightness of the peroxyoxalate chemiluminescence partially due to the hydrolysis of the oxalate reagent. Here, we show that encapsulation of an oxalate ester and the fluorescent activator in microspheres of cellulose esters increases the emission intensity 30 times compared to the same reaction in water without encapsulation, whereas the emission intensity decay rate constants are considerably lower. Emission intensities, rate constants and chemiluminescence quantum yields increase with increasing hydrogen peroxide concentrations. These results expand the potential of application of chemiluminescence, contributing for the development of ultrasensitive analytical methods.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1086-1095"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triplet states nurture the long-lived emission at room temperature of a chlorine-containing tetraphenylimidazole derivative when aggregation occurs in water/acetonitrile mixtures.","authors":"Leonardo Martins Carneiro, Diego Ulysses Melo, Calvin Quessada Cabello, Paula Homem-de-Mello, Fabio Furlan Ferreira, Fernando Heering Bartoloni","doi":"10.1111/php.14096","DOIUrl":"10.1111/php.14096","url":null,"abstract":"<p><p>In recent years, there have been numerous reports on the synthesis and applications of 1,2,4,5-tetraphenylimidazole (TEPI) derivatives, particularly due to the photophysical properties of such systems. However, the long-lived emission behavior of TEPIs has not been studied, with research largely limited to attempts at 77 K. In this study, the compound 1-(4-chlorophenyl)-2,4,5-triphenyl-1H-imidazole (TEPI-Cl) was prepared and characterized using experimental techniques (i.e., absorption spectra, steady-state, and long-lived emission), as well as computationally, using a combination of Extended Tight Binding (xTB), Density Functional Theory (DFT), and Time-Dependent (TD-DFT) methods. TEPI-Cl exhibited a low solvatochromic effect, both in absorption and steady-state emission in organic solvents, which is typical of a locally excited transition; this was confirmed by the performed calculations. However, in its aggregated state (observed in water/acetonitrile mixtures with >80% of water, in volume), the compound displayed the emergence of a new band in the absorption spectrum, as well as aggregate-induced enhanced emission in the steady-state emission analysis. The long-lived emission spectrum of TEPI-Cl recorded at room temperature shows two signals (at 380 and 540 nm) and the presence of benzil enables the generation of triplet excited states of the latter, likely through an energy transfer process. The sensitivity of these signals to the presence of oxygen suggested that the related excited states are of a triplet nature; moreover, the calculated electronic transitions for the optimized structures of the T₁ and T₂ states are comparable to the experimentally observed long-lived emission wavelengths. This newly observed behavior of TEPI-Cl comes as a novel photophysical property added to this class of molecules, demonstrating its significant potential for further applications in complex matrices.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1027-1038"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of chatbots in queries concerning fundamental concepts in photochemistry.","authors":"Masahiko Taniguchi, Jonathan S Lindsey","doi":"10.1111/php.14037","DOIUrl":"10.1111/php.14037","url":null,"abstract":"<p><p>The advent of chatbots raises the possibility of a paradigm shift across society including the most technical of fields with regard to access to information, generation of knowledge, and dissemination of education and training. Photochemistry is a scientific endeavor with roots in chemistry and physics and branches that encompass diverse disciplines ranging from astronomy to zoology. Here, five chatbots have each been challenged with 13 photochemically relevant queries. The chatbots included ChatGPT 3.5, ChatGPT 4.0, Copilot, Gemini Advanced, and Meta AI. The queries encompassed fundamental concepts (e.g., \"Why is the fluorescence spectrum typically the mirror image of the absorption spectrum?\"), practical matters (e.g., \"What is the inner filter effect and how to avoid it?\"), philosophical matters (\"Please create the most important photochemistry questions.\"), and specific molecular features (e.g., \"Why are azo dyes non-fluorescent?\"). The chatbots were moderately effective in answering queries concerning fundamental concepts in photochemistry but were glaringly deficient in specialized queries for dyes and fluorophores. In some instances, a correct response was embedded in verbose scientific nonsense whereas in others the entire response, while grammatically correct, was utterly meaningless. The unreliable accuracy makes present chatbots poorly suited for unaided educational purposes and highlights the importance of domain experts.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"886-895"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV-A photodegradation of vanillin in aqueous solutions: Direct photolysis and photosensitized degradation.","authors":"Heryerli Fernandez, Leo Niederst, Cécile Joyeux, Xavier Allonas, Carolina Lorente","doi":"10.1111/php.14051","DOIUrl":"10.1111/php.14051","url":null,"abstract":"<p><p>Phototoxicity of skin due to the application of skincare products or fragrances is increasing from day to day, since a lot of natural extracts, with low or no toxicity in the dark, are being used in the skin exposed to solar radiation. In particular, the use of 4-hydroxy-3-methoxy benzaldehyde, known as vanillin, in the pharmaceutical, food, and cosmetic industries has increased in the last years. This compound is generally considered as safe for humans, and it has been used in a wide range of applications. Significant beneficial properties, such as antioxidant, anticancer, antimicrobial, among others, have been described for vanillin, along with low toxicity. However, although vanillin is used as an ingredient in cosmetic formulations that are applied to the skin, there are few studies on the photochemistry of vanillin degradation. The degradation of vanillin in aqueous solutions exposed to UV-A radiation (365 nm), both by direct absorption and by means of a photosensitized mechanism, was evaluated in different experimental conditions. On the bases of the experimental results, direct photodegradation of vanillin seems unlikely; however, photosensitized degradation of vanillin was observed in the presence of pterin, and vanillin dimers (6,6-dihydroxy-5,5- dimethoxy-[1,1-biphenyl]-3,3-dicarboxaldehyde) were detected as products. The mechanistic analysis indicates that the long-lived pterin triplet excited state is responsible of vanillin degradation, while the contribution of reactive oxygen species, such as superoxide anion, hydrogen peroxide, or singlet oxygen, is negligible. The thermodynamic feasibility of the potential reactions involved in the degradation mechanism was evaluated with the Rehm-Weller equation. Considering both the thermodynamic and kinetic evidence, we proposed a mechanism for the photosensitized degradation of vanillin.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1049-1060"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photochemical inheritance of Eduardo Lissi and Juan Grotewold and the intersystem crossings with other inheritances.","authors":"Silvia E Braslavsky, Carlos M Previtali","doi":"10.1111/php.14044","DOIUrl":"10.1111/php.14044","url":null,"abstract":"<p><p>In 1963, Eduardo Lissi and Juan Grotewold started a chemical kinetics and photochemistry group at the School of Sciences at the University of Buenos Aires (Facultad de Ciencias Exactas y Naturales, FCEN, UBA). Political circumstances in Argentina and in Chile were a great determinant of the evolution, dispersion, and re-encounters of the group members. The initial graduate students in the group developed their own research groups working in various Countries and on a variety of projects. We relate the story of the strong interactions with each other of the original group as well as the cooperations and synergy (Intersystem Crossings) of Lissi and Grotewold and of their descendants with other research groups, mainly (but not only) in Latin America. A strong network of partnerships, friendships, and fruitful collaborations between the kineticists, photochemists, and photobiologists in Argentina, Chile and Brazil has evolved from the initial steps in the 1960s.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"790-832"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From femtoseconds to minutes: Spectroscopic study of optically induced thermal diffusion in aqueous solution of rhodamine B.","authors":"René A Nome, Alexandre H Oliveira","doi":"10.1111/php.14042","DOIUrl":"10.1111/php.14042","url":null,"abstract":"<p><p>Given that non-equilibrium molecular motion in thermal gradients is influenced by both solute and solvent, the application of spectroscopic methods that probe each component in a binary mixture can provide insights into the molecular mechanisms of thermal diffusion for a large class of systems. In the present work, we use an all-optical setup whereby near-infrared excitation of the solvent leads to a steady-state thermal gradient in solution, followed by characterization of the non-equilibrium system with electronic spectroscopy, imaging, and intensity. Using rhodamine B in water as a case study, we perform measurements as a function of solute concentration, temperature, wavelength, time, near-infrared laser power, visible excitation wavelength, and isotope effect. We find that spectroscopic excitation of solute and solvent as a function of temperature can be used to understand the thermal diffusion signal. Non-equilibrium molecular dynamics simulations and analysis of infrared spectra and heat diffusion, and stochastic dynamics simulations of the coupled Brownian/spectroscopic non-equilibrium dynamics. The stochastic/spectroscopic model shows how near-infrared excitation of the solvent influences lifetime dynamics on the picosecond timescale as well as Brownian dynamics in real time. Overall, the results presented here exemplify how spectroscopic probing of solute and solvent can be useful for understanding molecular mechanisms of optically induced thermal diffusion in aqueous solution of rhodamine B.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1013-1026"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GOUTERMAN - A module for simulations of tetrapyrrole optical spectra.","authors":"Hai Du, Masahiko Taniguchi, James R Diers, Christine Kirmaier, David F Bocian, Jonathan S Lindsey, Dewey Holten","doi":"10.1111/php.14057","DOIUrl":"10.1111/php.14057","url":null,"abstract":"<p><p>Tetrapyrrole macrocycles comprise the pigments of life (heme, chlorophylls, etc.) and together with synthetic analogues also find wide use in materials chemistry and the life sciences. The distinct colors of the various macrocycles are essential features. A time-honored approach for understanding the electronic spectra entails analyzing the impact of molecular composition on the relative energies of the four frontier molecular orbitals (MOs) of these 18-π annulenes. While first introduced by Prof. Martin Gouterman in 1959, use of the four-orbital model has been largely conceptual. Here, a computational module (GOUTERMAN) is introduced that takes as input the energies of the four MOs, provides user control over key parameters (configuration-interaction energies, dipole strengths, spectral widths), and outputs simulated absorption spectra. The energies of the MOs can be calculated independently (e.g., from density functional theory) or drawn from a small database that is provided. The MO energies and key parameters can be toggled and spectral changes viewed. The GOUTERMAN module is available in PhotochemCAD as a tool for both specialists and non-specialists to visualize, via hands-on experience, the connections between the structural and spectral properties of the tetrapyrrole chromophores found ubiquitously in Nature and used widely in research.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"869-885"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes.","authors":"Gabriel Grube Dos Santos, Amanda Cristina Zangirolami, Maria Luiza Ferreira Vicente, Vanderlei Salvador Bagnato, Kate Cristina Blanco","doi":"10.1111/php.14054","DOIUrl":"10.1111/php.14054","url":null,"abstract":"<p><p>Fungal infections related to biofilm formation on medical devices, such as endotracheal tubes (ETTs), pose significant health risks, especially during intubation procedures where fungi like Candida spp. can migrate into the lower respiratory tract. This study explores the use of Photodynamic Therapy (PDT) to prevent fungal cell migration from ETT surfaces to lungs, focusing on the role of curcumin as a photosensitizer. ETTs were coated with varying concentrations of curcumin, and biofilm formation was measured after applying PDT with a 50 J/cm² irradiation dose. The study found that ETTs functionalized with a one-third concentration of CUR reduced biofilm formation by 1.78 Log, significantly lowering microbial load and potentially decreasing hospital-acquired infections. Confocal fluorescence microscopy confirmed that PDT damaged the biofilm's extracellular matrix and caused detachment of dead fungal cells. Moreover, the fluorescence analysis reveals the photodegradation behavior of the photosensitizer within the tube, providing critical insights into its stability and durability, which are essential for evaluating the long-term applicability of these tubes in clinical settings. These results suggest PDT as a promising strategy to reduce fungal infections in high-risk patients, offering potential for future clinical application in preventing device-associated infections.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"858-868"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing bone remodeling and accelerating tooth movement with photobiomodulation in middle-aged adults.","authors":"Selly S Suzuki, Amanda M Ribeiro, Marcella U R Fernandes, Chooryung Chung, Aguinaldo S Garcez","doi":"10.1111/php.14089","DOIUrl":"10.1111/php.14089","url":null,"abstract":"<p><p>Although age is not a contraindication for orthodontic treatment, it can be considered more challenging in mature adult patients, mainly due to a less responsive bone metabolism and reduced osteoblastic activity compared to young patients. In orthodontics, photobiomodulation (PBM) has shown positive results in bone remodeling during tooth movement. This study seeks to assess the effect of PBM can have a positive effect on bone remodeling, stimulating bone formation in middle-aged individuals and allowing for a better periodontal condition. Bone structure and the length of the roots were evaluated using cone beam computed tomography images before and after tooth movement and PBM in patients aged between 40 and 60 years. In addition, we aimed to evaluate the expression of the markers receptor activator of NFκB (RANK), osteoprotegerin (OPG), and osteopontin (OPN) presented in the crevicular fluid using the enzyme-linked immunosorbent assay test. Tooth movement was performed by intruding upper molars with two mini-implants as anchorage bilaterally. One side received PBM with light-emitting diode (LED) light and the contralateral side was used as control (no irradiation). The PBM equipment specially designed for this study consisted of six LEDs of 5 mW each, for 7 minutes, totaling 2 J, 3 times a week, for 5 months. The PMB group showed greater tooth movement (p < 0.05), an increase of 74% on average for bone height. PBM induced a significant increase in RANK expression at month 3 (p < 0.05), and the expression of OPG and OPN showed a significant increase in the fifth month of movement (p < 0.05) in the PBM group. PBM may represent an adjunct therapeutic approach during tooth movement in more mature patients, leading to a more responsive bone metabolism and favoring more comprehensive orthodontic treatment.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"904-912"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}