Photochemistry and Photobiology最新文献_第10页

The acid sphingomyelinase inhibitor imipramine enhances the release of UV photoproduct-containing DNA in small extracellular vesicles in UVB-irradiated human skin. 酸性鞘磷脂酶抑制剂亚胺培南能增强紫外线照射下人体皮肤细胞外小泡中含有紫外线光电导体的DNA的释放。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-03 DOI: 10.1111/php.13932

M Alexandra Carpenter, Anita Thyagarajan, Madison Owens, Risha Annamraju, Christina B Borchers, Jeffrey B Travers, Michael G Kemp

{"title":"The acid sphingomyelinase inhibitor imipramine enhances the release of UV photoproduct-containing DNA in small extracellular vesicles in UVB-irradiated human skin.","authors":"M Alexandra Carpenter, Anita Thyagarajan, Madison Owens, Risha Annamraju, Christina B Borchers, Jeffrey B Travers, Michael G Kemp","doi":"10.1111/php.13932","DOIUrl":"10.1111/php.13932","url":null,"abstract":"Nucleic acids, lipids, and other cell components can be found within different types of extracellular vesicles (EVs), which include apoptotic bodies (ABs), large extracellular vesicles (LEVs), and small extracellular vesicles (SEVs). Release of LEVs from cells can be reduced by genetic or pharmacological inhibition of the enzyme acid sphinogomyelinase (aSMase), and indeed several studies have demonstrated a role for the clinically approved aSMase inhibitor imipramine in blocking LEV release, including in response to UVB exposure. Given that exposure of keratinocytes to UVB radiation results in the generation of UVR photoproducts in DNA that can subsequently be found in association with ABs and SEVs, we examined how imipramine impacts the release of extracellular DNA containing UVR photoproducts at an early time point after UVR exposure. Using several different model systems, including cultured keratinocytes in vitro, discarded human surgical skin ex vivo, and skin biopsies obtained from treated human subjects, these pilot studies suggest that imipramine treatment stimulates the release of CPD-containing, SEV-associated DNA. These surprising findings indicate that LEV and SEV generation pathways could be linked in UVB-irradiated cells and that imipramine may exacerbate the systemic effects of extracellular UVR-damaged DNA throughout the body.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1894-1901"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The REV-ERB antagonist SR8278 modulates keratinocyte viability in response to UVA and UVB radiation. REV-ERB 拮抗剂 SR8278 可调节角质细胞对 UVA 和 UVB 辐射的活力。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-08 DOI: 10.1111/php.13930

William Cvammen, Michael G Kemp

{"title":"The REV-ERB antagonist SR8278 modulates keratinocyte viability in response to UVA and UVB radiation.","authors":"William Cvammen, Michael G Kemp","doi":"10.1111/php.13930","DOIUrl":"10.1111/php.13930","url":null,"abstract":"The nucleotide excision repair (NER) system removes UV photoproducts from genomic DNA and is controlled by the circadian clock. Given that small-molecule compounds have been developed to target various clock proteins, we examined whether the cryptochrome inhibitor KS15 and REV-ERB antagonist SR8278 could modulate keratinocyte responses to UV radiation in vitro. We observed that though SR8278 promoted cell viability in UVB-irradiated cells, it had little effect on NER or on the expression of the clock-regulated NER factor XPA. Rather, we found that both KS15 and SR8278 absorb light within the UV spectrum to limit initial UV photoproduct formation in DNA. Moreover, SR8278 promoted UVB viability even in cells in which the core circadian clock protein BMAL1 was disrupted, which indicates that SR8278 is likely acting via other REV-ERB transcriptional targets. We further observed that SR8278 sensitized keratinocytes to light sources containing primarily UVA wavelengths of light likely due to the generation of toxic reactive oxygen species. Though other studies have demonstrated beneficial effects of SR8278 in other model systems, our results here suggest that SR8278 has limited utility for UV photoprotection in the skin and will likely cause phototoxicity in humans or mammals exposed to solar radiation.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1864-1873"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy: Critical PDT theory IX-Translational efforts. 光动力疗法：关键PDT理论IX转化努力。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2023-10-09 DOI: 10.1111/php.13867

David Kessel

引用次数: 0

Potential of using medicinal plant extracts as photosensitizers for antimicrobial photodynamic therapy. 将药用植物提取物作为光敏剂用于抗菌光动力疗法的潜力。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-08 DOI: 10.1111/php.13935

Aliaksandr V Mikulich, Vitaly Yu Plavskii, Antonina I Tretyakova, Raman K Nahorny, Andrey N Sobchuk, Natalia V Dudchik, Olga A Emeliyanova, Anastasia I Zhabrouskaya, Ludmila G Plavskaya, Tatsiana S Ananich, Olga N Dudinova, Ihar A Leusenka, Sergey V Yakimchuk, Alexei D Svechko, Tran Quoc Tien, Quang Cong Tong, Thanh Phuong Nguyen

{"title":"Potential of using medicinal plant extracts as photosensitizers for antimicrobial photodynamic therapy.","authors":"Aliaksandr V Mikulich, Vitaly Yu Plavskii, Antonina I Tretyakova, Raman K Nahorny, Andrey N Sobchuk, Natalia V Dudchik, Olga A Emeliyanova, Anastasia I Zhabrouskaya, Ludmila G Plavskaya, Tatsiana S Ananich, Olga N Dudinova, Ihar A Leusenka, Sergey V Yakimchuk, Alexei D Svechko, Tran Quoc Tien, Quang Cong Tong, Thanh Phuong Nguyen","doi":"10.1111/php.13935","DOIUrl":"10.1111/php.13935","url":null,"abstract":"Antimicrobial photodynamic therapy (APDT) is a promising approach to overcome antimicrobial resistance. However, for widespread implementation of this approach, approved photosensitizers are needed. In this study, we used commercially available preparations (Calendulae officinalis floridis extract, Chamomillae recutitae floridis extract, Achillea millefolii herbae extract; Hypericum perforatum extract; Eucalyptus viminalis folia extract) as photosensitizers for inactivation of gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria. Spectral-luminescent analysis has shown that the major chromophores are of chlorophyll (mainly chlorophyll a and b) and hypericin nature. The extracts are efficient generators of singlet oxygen with quantum yield (γΔ) from 0.40 to 0.64 (reference compound, methylene blue with γΔ = 0.52). In APDT assays, bacteria before irradiation were incubated with extracts for 30 min. After irradiation and 24 h of incubation, colony-forming units (CFU) were counted. Upon exposure of P. aeruginosa to radiation of 405 nm, 590 nm, and 660 nm at equal energy dose of 30 J/cm2 (irradiance - 100 mW/cm2, exposure time - 5 min), the most pronounced effect is observed with blue light (>3 log10 reduction); in case of S. aureus, the effect is approximately equivalent for light of indicated wavelengths and dose (>4 log10 reduction).","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1833-1847"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of lapatinib for enhancing 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy in human cancer cell lines with varied ABCG2 activities. 拉帕替尼在具有不同 ABCG2 活性的人类癌细胞系中增强 5-氨基乙酰丙酸介导的原卟啉 IX 荧光和光动力疗法的效果。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-13 DOI: 10.1111/php.13936

Richard Howley, Jordyn Olsen, Bin Chen

{"title":"Effectiveness of lapatinib for enhancing 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy in human cancer cell lines with varied ABCG2 activities.","authors":"Richard Howley, Jordyn Olsen, Bin Chen","doi":"10.1111/php.13936","DOIUrl":"10.1111/php.13936","url":null,"abstract":"5-Aminolevulinic acid (ALA) is a prodrug for protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) and fluorescence-guided tumor surgery. We previously reported that lapatinib, a repurposed ABCG2 inhibitor, enhanced ALA-induced PpIX fluorescence and PDT by blocking ABCG2-mediated PpIX efflux. In the present study, we evaluated how the variation in ABCG2 activities/protein levels affected tumor cell response to the enhancement of PpIX/PDT by lapatinib and Ko143, an ABCG2 tool inhibitor. ABCG2 activities and protein levels were determined in a panel of human cancer cell lines. Effects of lapatinib and Ko143 on enhancing ALA-PpIX fluorescence and PDT were evaluated and correlated with tumor cell ABCG2 activities. We found that both lapatinib and Ko143 enhanced ALA-PpIX fluorescence and PDT in a dose-dependent manner, although lapatinib exhibited lower efficacy and potency than Ko143 in nearly all cancer cell lines. The EC50 of ABCG2 inhibitors for enhancing ALA-PpIX and PDT had a positive correlation with tumor cell ABCG2 activities, indicating that tumor cell lines with lower ABCG2 activities were more sensitive to ABCG2 inhibitors for PpIX/PDT enhancement. Our results suggest that, for optimal therapeutic enhancement, the dose of ABCG2 inhibitors needs to be tailored based on the ABCG2 expression/activity in tumors.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1579-1589"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of covalently coupled eosin-Y with B_en-graphitic carbon nitride framework for improved photocatalytic activity in solar light-driven Biginelli product generation and NADH regeneration. 共价偶联曙红-Y 与本石墨氮化碳框架的协同效应可提高太阳光驱动的比吉内利产物生成和 NADH 再生的光催化活性。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-06-28 DOI: 10.1111/php.13986

Anurag Prajapati, Rajesh K Yadav, Rehana Shahin, Ravindra Shukla, Shaifali Mishra, Satyam Singh, Suman Yadav, Jin-OoK Baeg, Rajat Singhal, Navneet K Gupta, Mohd Sajid Ali, Krishna Kumar Yadav

{"title":"Synergistic effects of covalently coupled eosin-Y with Ben-graphitic carbon nitride framework for improved photocatalytic activity in solar light-driven Biginelli product generation and NADH regeneration.","authors":"Anurag Prajapati, Rajesh K Yadav, Rehana Shahin, Ravindra Shukla, Shaifali Mishra, Satyam Singh, Suman Yadav, Jin-OoK Baeg, Rajat Singhal, Navneet K Gupta, Mohd Sajid Ali, Krishna Kumar Yadav","doi":"10.1111/php.13986","DOIUrl":"10.1111/php.13986","url":null,"abstract":"Elevated global pollution level is the prime reason that contributes to the onset of various harmful health diseases. The products of Biginelli reaction are enormously used in the pharmaceutical industry as they have antiviral, antibacterial, and calcium channel modulation abilities. This work reports a novel eosin Y sensitized boron graphitic carbon nitride (EY-Ben-g-C3N4) as a photocatalyst that efficiently produced 3,4-dihydropyrimidine-2-(1H)-one by the Biginelli reaction of benzaldehyde, urea, and methyl acetoacetate. The photocatalyst EY-Ben-g-C3N4 showed a successful generation of 3,4-dihydropyrimidine-2-(1H)-one (Biginelli product) in good yield via photocatalysis which is an eco-friendly method and has facile operational process. In addition to the production of Biginelli products, the photocatalyst also showed a remarkable NADH regeneration of 81.18%. The incorporation of g-C3N4 with boron helps increase the surface area and the incorporation of eosin Y which is an inexpensive and non-toxic dye, and in Ben-g-C3N4, enhanced the light-harvesting capacity of the photocatalyst. The production of 3,4-dihydropyrimidine-2-(1H)-one and NADH by the EY-Ben-g-C3N4 photocatalyst is attributed to the requisite band gap, high molar absorbance, low rate of charge recombination, and increased capacity of the photocatalyst to harvest solar light energy.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1773-1786"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shades of phototoxicity in fluorescent imaging agents (that are not supposed to be phototoxic). 荧光成像剂（不应该具有光毒性）的光毒性阴影。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2023-09-12 DOI: 10.1111/php.13856

Serah Essang, Alexander Greer

引用次数: 0

Effect of 980 nm photobiomodulation delivered by a handpiece with Gaussian vs. Flat-Top profiles on proliferation and differentiation of buccal fat pad stem cells. 高斯曲线与平顶曲线手机发出的 980 纳米光生物调制对颊脂垫干细胞增殖和分化的影响。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-10 DOI: 10.1111/php.13929

Ali Homayouni, Maryam Rezaie Rad, Hamidreza Barikani, Nasim Chiniforush, Solmaz Akbari

{"title":"Effect of 980 nm photobiomodulation delivered by a handpiece with Gaussian vs. Flat-Top profiles on proliferation and differentiation of buccal fat pad stem cells.","authors":"Ali Homayouni, Maryam Rezaie Rad, Hamidreza Barikani, Nasim Chiniforush, Solmaz Akbari","doi":"10.1111/php.13929","DOIUrl":"10.1111/php.13929","url":null,"abstract":"The aim of this study was to compare the effectiveness of the Gaussian and Flat-Top profiles in proliferation and differentiation of mesenchymal stem cell of buccal fat pad. Based on the timing schedule and type of laser handpieces, the cells were assigned to a control group with no radiation, and two irradiation test groups (980 nm) with Flat-Top (F) (power of 1.1 W, beam area of 1 cm2) and standard Gaussian (G) (power of 0.7 W, beam area of 0.5 cm2) handpieces. Each test group was divided into three subgroups, receiving one time (60 J/cm2), two times (120 J/cm2), and three times (180 J/cm2) irradiation. 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and Annexin V tests were performed. The Alizarin Red staining and polymerase chain reaction tests were done both at the beginning and the end of the first and second weeks. The degree of mineralization and expression of osteogenic markers, RUNX2, OCN, and OPN were evaluated. Based on the MTT and Annexin V test results, both test groups outperformed the control group in degrees of cell proliferation during the first day of laser irradiation (p < 0.05). After one and two times irradiation, the expression of osteogenic markers in the test groups was significantly higher than the control group. PBM with Flat-Top and Gaussian handpieces can enhance ossification and cell differentiation regardless of the type of handpieces.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1902-1911"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A single photodynamic priming protocol augments delivery of ⍺-PD-L1 mAbs and induces immunogenic cell death in head and neck tumors. 在头颈部肿瘤中，单一的光动力启动方案增加了PD-L1单克隆抗体的递送并诱导免疫原性细胞死亡。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2023-10-11 DOI: 10.1111/php.13865

Chanda Bhandari, Azophi Moffat, John Fakhry, Ashritha Malkoochi, Austin Nguyen, Brian Trinh, Kenneth Hoyt, Michael D Story, Tayyaba Hasan, Girgis Obaid

{"title":"A single photodynamic priming protocol augments delivery of ⍺-PD-L1 mAbs and induces immunogenic cell death in head and neck tumors.","authors":"Chanda Bhandari, Azophi Moffat, John Fakhry, Ashritha Malkoochi, Austin Nguyen, Brian Trinh, Kenneth Hoyt, Michael D Story, Tayyaba Hasan, Girgis Obaid","doi":"10.1111/php.13865","DOIUrl":"10.1111/php.13865","url":null,"abstract":"Photodynamic priming (PDP) leverages the photobiological effects of subtherapeutic photodynamic therapy (PDT) regimens to modulate the tumor vasculature and stroma. PDP also sensitizes tumors to secondary therapies, such as immunotherapy by inducing a cascade of molecular events, including immunogenic cell death (ICD). We and others have shown that PDP improves the delivery of antibodies, among other theranostic agents. However, it is not known whether a single PDP protocol is capable of both inducing ICD in vivo and augmenting the delivery of immune checkpoint inhibitors. In this rapid communication, we show for the first time that a single PDP protocol using liposomal benzoporphyrin derivative (Lipo-BPD, 0.25 mg/kg) with 690 nm light (75 J/cm2, 100 mW/cm2) simultaneously doubles the delivery of ⍺-PD-L1 antibodies in murine AT-84 head and neck tumors and induces ICD in vivo. ICD was observed as a 3-11 fold increase in tumor cell exposure of damage-associated molecular patterns (Calreticulin, HMGB1, and HSP70). These findings suggest that this single, highly translatable PDP protocol using clinically relevant Lipo-BPD holds potential for improving immunotherapy outcomes in head and neck cancer. It can do so by simultaneously overcoming physical barriers to the delivery of immune checkpoint inhibitors, and biochemical barriers that contribute to immunosuppression.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1647-1658"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41208987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test method for evaluating the photocytotoxic potential of fluorescence imaging products. 评估荧光成像产品光细胞毒性潜力的测试方法。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2023-07-26 DOI: 10.1111/php.13836

Shruti Vig, Brandon Gaitan, Lucas Frankle, Yu Chen, Rosalie Elespuru, T Joshua Pfefer, Huang-Chiao Huang

{"title":"Test method for evaluating the photocytotoxic potential of fluorescence imaging products.","authors":"Shruti Vig, Brandon Gaitan, Lucas Frankle, Yu Chen, Rosalie Elespuru, T Joshua Pfefer, Huang-Chiao Huang","doi":"10.1111/php.13836","DOIUrl":"10.1111/php.13836","url":null,"abstract":"Various fluorescence imaging agents are currently under clinical studies. Despite significant benefits, phototoxicity is a barrier to the clinical translation of fluorophores. Current regulatory guidelines on medication-based phototoxicity focus on skin effects during sun exposure. However, with systemic and local administration of fluorophores and targeted illumination, there is now possibility of photochemical damage to deeper tissues during intraoperative imaging procedures. Hence, independent knowledge regarding phototoxicity is required to facilitate the development of fluorescence imaging products. Previously, we studied a cell-free assay for initial screening of reactive molecular species generation from fluorophores. The current work addresses a safety test method based on cell viability as an adjunct and a comparator with the cell-free assay. Our goal is to modify and implement an approach based on the in vitro 3T3 neutral red uptake assay of the Organization for Economic Co-Operation and Development Test Guideline 432 (OECD TG432) to evaluate the photocytotoxicity of clinically relevant fluorophores. These included indocyanine green (ICG), proflavine, methylene blue (MB), and IRDye800, as well as control photosensitizers, benzoporphyrin derivative (BPD) and rose bengal (RB). We performed measurements at agent concentrations and illumination parameters used for clinic imaging. Our results aligned with prior studies, indicating photocytotoxicity in RB and BPD and an absence of reactivity for ICG and IRDye800. DNA interactive agents, proflavine and MB, exhibited drug/light dose-response curves like photosensitizers. This study provides evidence and insights into practices useful for testing the photochemical safety of fluorescence imaging products.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1561-1578"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0