Photochemistry and Photobiology最新文献_第10页

Revealing the ESIPT process in benzoxazole fluorophores within polymeric matrices through theory and experiment. 通过理论和实验揭示聚合物基质中苯并噁唑荧光团的 ESIPT 过程。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-26 DOI: 10.1111/php.13991

Luís Gustavo Teixeira Alves Duarte, Emmanuel Santos Moraes, Priscila Sayoko Silva Wakabayashi, Lilian Camargo da Luz, Rodrigo Cercená, Eduardo Zapp, Teresa Dib Zambon Atvars, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch

{"title":"Revealing the ESIPT process in benzoxazole fluorophores within polymeric matrices through theory and experiment.","authors":"Luís Gustavo Teixeira Alves Duarte, Emmanuel Santos Moraes, Priscila Sayoko Silva Wakabayashi, Lilian Camargo da Luz, Rodrigo Cercená, Eduardo Zapp, Teresa Dib Zambon Atvars, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch","doi":"10.1111/php.13991","DOIUrl":"https://doi.org/10.1111/php.13991","url":null,"abstract":"The impact of the polymeric matrix on the photophysical characteristics of monomeric dyes responsive to excited-state intramolecular proton transfer (ESIPT) was investigated through UV-Vis absorption as well as steady-state and time-resolved emission spectroscopies. For this purpose, two benzoxazole monomers (M1 and M2) with acryloyl groups at different positions in their molecular structures were employed to facilitate covalent bonding within a styrene chain. Our findings reveal significant variations in their excited-state properties due to the proximity of the acryloyl groups, which affects the energy barrier of the ESIPT reaction, the emission wavelength, and the balance between the normal and tautomeric forms. The experimental results were corroborated through theoretical investigations at the DFT/TDDFT level, specifically using the B3LYP-D3/def2-TZVP methodology. Three notable observations emerged: donor/acceptor groups at the meta/para positions induced electron distribution changes, causing red-shifted emission for M2; in the polymer film, particularly in PM1, intramolecular hydrogen bond deactivation favored N* emission over T* emission; and the zwitterionic character of the T* species. This study underscores the advantages of functionalization in polymers, which can lead to colorless films and prevalent N* or T* emission, and contributes valuable insights into molecular design strategies for tailoring the photophysical properties of polymeric materials.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiomodulation of Na,K-ATPase in native membrane fraction and reconstituted in DPPC:DPPE-liposome. 原生膜部分和在 DPPC:DPPE 脂质体中重组的 Na,K-ATP 酶的光生物调节。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-24 DOI: 10.1111/php.13987

Gustavo Scanavachi, Juliana S Yoneda, Heitor G Sebinelli, Leandro R S Barbosa, Pietro Ciancaglini, Rosangela Itri

{"title":"Photobiomodulation of Na,K-ATPase in native membrane fraction and reconstituted in DPPC:DPPE-liposome.","authors":"Gustavo Scanavachi, Juliana S Yoneda, Heitor G Sebinelli, Leandro R S Barbosa, Pietro Ciancaglini, Rosangela Itri","doi":"10.1111/php.13987","DOIUrl":"https://doi.org/10.1111/php.13987","url":null,"abstract":"Studies focusing on how photobiomodulation (PBM) can affect the structure and function of proteins are scarce in the literature. Few previous studies have shown that the enzymatic activity of Na,K-ATPAse (NKA) can be photo-modulated. However, the variability of sample preparation and light irradiation wavelengths have not allowed for an unequivocal conclusion about the PBM of NKA. Here, we investigate minimal membrane models containing NKA, namely, native membrane fraction and DPPC:DPPE proteoliposome upon laser irradiation at wavelengths 532, 650, and 780 nm. Interestingly, we show that the PBM on the NKA enzymatic activity has a bell-shaped profile with a stimulation peak (~15% increase) at around 20 J.cm-2 and 6 J.cm-2 for the membrane-bound and the proteoliposome samples, respectively, and are practically wavelength independent. Further, by normalizing the enzymatic activity by the NKA enzyme concentration, we show that the PBM response is related to the protein amount with small influence due to protein's environment. The stimulation decays over time reaching the basal level around 6 h after the irradiation for the three lasers and both NKA samples. Our results demonstrate the potential of using low-level laser therapy to modulate NKA activity, which may have therapeutic implications and benefits.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photochemistry of N-aryl and N-alkyl dibenzothiophene sulfoximines. N- 芳基和 N- 烷基二苯并噻吩亚磺酰亚胺的光化学。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-24 DOI: 10.1111/php.13978

John C Throgmorton, Alexis J Iverson, Ryan D McCulla

{"title":"Photochemistry of N-aryl and N-alkyl dibenzothiophene sulfoximines.","authors":"John C Throgmorton, Alexis J Iverson, Ryan D McCulla","doi":"10.1111/php.13978","DOIUrl":"https://doi.org/10.1111/php.13978","url":null,"abstract":"N-phenyl dibenzothiophene sulfoximine has been demonstrated to produce phenyl nitrene and dibenzothiophene S-oxide upon irradiation with UV-A light, and dibenzothiophene S-oxide upon further irradiation releases triplet atomic oxygen. Thus, N-phenyl dibenzothiophene sulfoximine exhibits a rare dual-release capability in its photochemistry. In this work, N-substituted dibenzothiophene sulfoximine derivatives are irradiated with UV-A light to compare their photochemistry and quantum yield of dibenzothiophene S-oxide production with that of N-phenyl dibenzothiophene sulfoximine. Both N-aryl and N-alkyl derivatives of dibenzothiophene sulfoximine are examined to observe their effects on the quantum yield of the photolysis reaction. Adding electron withdrawing N-aryl substituents is shown to increase the quantum yield of dibenzothiophene S-oxide production, while adding electron donating N-aryl substituents is shown to decrease the quantum yield. The quantum yield was slightly lowered or not increased by most N-alkyl substituents. Furthermore, the quantum yield was not augmented by branching and steric hindrance effects associated with the N-alkyl substituents. These results suggest that electronic modulation of the sulfoximine bonds affects the observed photolysis reaction.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype. 红光激活难治性胶质母细胞瘤干细胞的耗竭和获得性耐药间质表型的化疗增敏。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-23 DOI: 10.1111/php.13985

Bryan Q Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Joseph W R Swain, Zhiming Mai, Hiroaki Wakimoto, Tayyaba Hasan

{"title":"Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype.","authors":"Bryan Q Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Joseph W R Swain, Zhiming Mai, Hiroaki Wakimoto, Tayyaba Hasan","doi":"10.1111/php.13985","DOIUrl":"10.1111/php.13985","url":null,"abstract":"Glioblastoma stem cells (GSCs) are potent tumor initiators resistant to radiochemotherapy, and this subpopulation is hypothesized to re-populate the tumor milieu due to selection following conventional therapies. Here, we show that 5-aminolevulinic acid (ALA) treatment-a pro-fluorophore used for fluorescence-guided cancer surgery-leads to elevated levels of fluorophore conversion in patient-derived GSC cultures, and subsequent red light-activation induces apoptosis in both intrinsically temozolomide chemotherapy-sensitive and -resistant GSC phenotypes. Red light irradiation of ALA-treated cultures also exhibits the ability to target mesenchymal GSCs (Mes-GSCs) with induced temozolomide resistance. Furthermore, sub-lethal light doses restore Mes-GSC sensitivity to temozolomide, abrogating GSC-acquired chemoresistance. These results suggest that ALA is not only useful for fluorescence-guided glioblastoma tumor resection, but that it also facilitates a GSC drug-resistance agnostic, red light-activated modality to mop up the surgical margins and prime subsequent chemotherapy.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Power‐dependent study of the photothermal response of several alcoholic media with femtosecond laser‐induced thermal lens 利用飞秒激光诱导热透镜对几种酒精介质的光热响应进行功率依赖性研究

IF 3.3 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-22 DOI: 10.1111/php.13980

Ashwini Kumar Rawat, Subhajit Chakraborty, Amit Kumar Mishra, Debabrata Goswami

{"title":"Power‐dependent study of the photothermal response of several alcoholic media with femtosecond laser‐induced thermal lens","authors":"Ashwini Kumar Rawat, Subhajit Chakraborty, Amit Kumar Mishra, Debabrata Goswami","doi":"10.1111/php.13980","DOIUrl":"https://doi.org/10.1111/php.13980","url":null,"abstract":"We explore the photothermal response of methanol, ethylene glycol, and glycerol using the femtosecond laser‐induced thermal lens spectroscopy (FTLS) technique. A mode mismatched pump–probe spectroscopic technique was utilized to analyze the influence of localized thermal heating on the photothermal response of solvents. The findings revealed a strong dependence on both the input pump power and the molecular characteristics of the solvents. At significantly high pump power, the excess heat load deposited to the solvent is found to be responsible for the induction of the convection currents in the heat transfer mechanisms. Our results highlight that the influence of pump power on photothermal and thermal lens characteristics is intricately linked to the natural drifting and heat transfer mechanisms of solvent molecules. The molecular motion and existing connective processes were correlated with the molecular characteristics of the samples. The present finding reveals that FTLS is a sensitive probe for comprehending the impact of input laser power, molecular structure, and intermolecular H bonding on the photothermal characteristics and thermo‐optical properties of the alcoholic medium.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141514817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoprotective efficacy of Sunset Yellow via inhibition of type-I and type-II pathway under exposure of sunlight. 日落黄在日光照射下通过抑制 I 型和 II 型途径发挥光保护作用。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-20 DOI: 10.1111/php.13966

Saurabh Singh, Durgesh Mourya, Sunil Kumar Patel, Sachin Shukla, Vijay Kumar, Sumana Y Kotian, Akhilesh K Yadav, Alok Pandey, Ashish Dwivedi, Anurag Tripathi

{"title":"Photoprotective efficacy of Sunset Yellow via inhibition of type-I and type-II pathway under exposure of sunlight.","authors":"Saurabh Singh, Durgesh Mourya, Sunil Kumar Patel, Sachin Shukla, Vijay Kumar, Sumana Y Kotian, Akhilesh K Yadav, Alok Pandey, Ashish Dwivedi, Anurag Tripathi","doi":"10.1111/php.13966","DOIUrl":"10.1111/php.13966","url":null,"abstract":"Exposure to phototoxicants and photosensitizers can result in the generation of reactive oxygen species (ROS), leading to oxidative stress, DNA damage, and various skin-related issues such as aging, allergies, and cancer. While several photo-protectants offer defense against ultraviolet radiation (UV-R), their effectiveness is often limited by photo-instability. Sunset Yellow (SY), an FDA-approved food dye, possesses significant UV-R and visible light absorption properties. However, its photoprotective potential has remained unexplored. Our investigation reveals that SY exhibits remarkable photostability for up to 8 h under both UV-R and sunlight. Notably, SY demonstrates the ability to quench ROS, including singlet oxygen (1O2), superoxide radicals ( <math> <semantics> <mrow><msubsup><mi>O</mi> <mn>2</mn> <mrow><mo>·</mo> <mo>-</mo></mrow> </msubsup> </mrow> <annotation>$$ {mathrm{O}}_2^{cdotp -} $$</annotation></semantics> </math> ), and hydroxyl radicals (·OH) induced by rose bengal, riboflavin and levofloxacin, respectively. Moreover, SY proves effective in protecting against the apoptotic and necrotic cell death induced by the phototoxicant chlorpromazine (CPZ) in HaCaT cells. Further, it was observed that SY imparts photoprotection by inhibiting intracellular ROS generation and calcium release. Genotoxicity evaluation provides additional evidence supporting SY's photoprotective effects against CPZ-induced DNA damage. In conclusion, these findings underscore the potential of SY as a promising photoprotective agent against the toxic hazards induced by phototoxicants, suggesting its prospective application in the formulation of broad-spectrum sunscreens.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How long does the biological effect of a red light-emitting diode last on adipose-derived mesenchymal stem cells? 红色发光二极管对脂肪间充质干细胞的生物效应能持续多久？

IF 3.3 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-18 DOI: 10.1111/php.13983

Vitor Pocani da Rocha, Barbara Sampaio Dias Martins Mansano, Carolina Fernanda Chaves Dos Santos, Ighor Luiz Azevedo Teixeira, Helenita Antonia de Oliveira, Stella Sousa Vieira, Ednei Luiz Antonio, Maria Cristina de Oliveira Izar, Francisco Antonio Helfenstein Fonseca, Andrey Jorge Serra

{"title":"How long does the biological effect of a red light-emitting diode last on adipose-derived mesenchymal stem cells?","authors":"Vitor Pocani da Rocha, Barbara Sampaio Dias Martins Mansano, Carolina Fernanda Chaves Dos Santos, Ighor Luiz Azevedo Teixeira, Helenita Antonia de Oliveira, Stella Sousa Vieira, Ednei Luiz Antonio, Maria Cristina de Oliveira Izar, Francisco Antonio Helfenstein Fonseca, Andrey Jorge Serra","doi":"10.1111/php.13983","DOIUrl":"https://doi.org/10.1111/php.13983","url":null,"abstract":"This research investigated the duration of the influence of red light-emitting diodes (LED, 630 nm; output power: 2452.5 mW; laser beam: 163.5 cm2; irradiance: 15 mW/cm2; radiant exposure: 4 J/cm2) on different periods after irradiation (6, 12, 24, 48, and 72 h) on adipose-derived mesenchymal stem cells' (AdMSCs) metabolism and paracrine factors. AdMSCs were irradiated three times every 48 h. Twenty-four hours after the last irradiation, there was a higher MTT absorbance, followed by a decrease after 48 h. The cells' secretome showed increased levels of IL-6 and VEGF after 12 and 24 h, but this was reversed after 48 h. Additionally, LED irradiation resulted in higher levels of nitrite and did not affect oxidative stress markers. LED irradiation had significant effects on AdMSCs after 24 h compared to other groups and its control group.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing PDT efficacy in NMIBC: Efflux inhibitor mediated improvement of PpIX levels and efficacy of the combination of PpIX-PDT and SO-cleavable prodrugs. 提高 PDT 在 NMIBC 中的疗效：外排抑制剂介导的 PpIX 水平改善以及 PpIX-PDT 和 SO 可裂解原药组合的疗效。

IF 3.3 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-12 DOI: 10.1111/php.13982

Soniya Kumbham, Kazi Md Mahabubur Rahman, Caroline Bosmajian, Ganesh Bist, Barbara A Foster, Sukyung Woo, Youngjae You

{"title":"Enhancing PDT efficacy in NMIBC: Efflux inhibitor mediated improvement of PpIX levels and efficacy of the combination of PpIX-PDT and SO-cleavable prodrugs.","authors":"Soniya Kumbham, Kazi Md Mahabubur Rahman, Caroline Bosmajian, Ganesh Bist, Barbara A Foster, Sukyung Woo, Youngjae You","doi":"10.1111/php.13982","DOIUrl":"https://doi.org/10.1111/php.13982","url":null,"abstract":"Protoporphyrin IX (PpIX)-based photodynamic therapy (PDT) has shown limited efficacy in nonmuscle-invasive bladder cancer (NMIBC). To improve PDT efficacy, we developed singlet oxygen-cleavable prodrugs. These prodrugs, when combined with PpIX-PDT, induce cancer cell death through both PDT and drug release mechanisms. Inhibition of PpIX efflux was reported to be an effective strategy to improve PpIX-PDT in certain cancer cells. Our main goal was to investigate whether adding an efflux inhibitor to the combination of PpIX and prodrugs can improve the PpIX levels in bladder cancer cells and the release of active drugs, thus improving the overall efficacy of the treatment. We treated bladder cancer cell lines with lapatinib and evaluated intracellular PpIX fluorescence, finding significantly increased accumulation. Combining lapatinib with prodrugs led to significantly reduced cell viability compared to prodrugs or PpIX-PDT alone. The effect of lapatinib depended on the expression level of the efflux pump in bladder cancer cells. Interestingly, lapatinib increased paclitaxel (PTX) prodrug uptake by threefold compared to prodrug alone. Adding an efflux inhibitor (e.g., lapatinib) into bladder instillation solutions could be a straightforward and effective strategy for NMIBC treatment, particularly in tumors expressing efflux pumps, with the potential for clinical translation.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance. 克服卵巢癌细胞系中流体剪切应力的影响：单用多柔比星或光动力引物针对铂类抗药性。

IF 3.3 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-07 DOI: 10.1111/php.13967

Marta Overchuk, Brittany P Rickard, Justin Tulino, Xianming Tan, Frances S Ligler, Huang-Chiao Huang, Imran Rizvi

{"title":"Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance.","authors":"Marta Overchuk, Brittany P Rickard, Justin Tulino, Xianming Tan, Frances S Ligler, Huang-Chiao Huang, Imran Rizvi","doi":"10.1111/php.13967","DOIUrl":"10.1111/php.13967","url":null,"abstract":"Resistance to platinum-based chemotherapies remains a significant challenge in advanced-stage high-grade serous ovarian carcinoma, and patients with malignant ascites face the poorest outcomes. It is, therefore, important to understand the effects of ascites, including the associated fluid shear stress (FSS), on phenotypic changes and therapy response, specifically FSS-induced chemotherapy resistance and the underlying mechanisms in ovarian cancer. This study investigated the effects of FSS on response to cisplatin, a platinum-based chemotherapy, and doxorubicin, an anthracycline, both of which are commonly used to manage advanced-stage ovarian cancer. Consistent with prior research, OVCAR-3 and Caov-3 cells cultivated under FSS demonstrated significant resistance to cisplatin. Examination of the role of mitochondria revealed an increase in mitochondrial DNA copy number and intracellular ATP content in cultures grown under FSS, suggesting that changes in mitochondria number and metabolic activity may contribute to platinum resistance. Interestingly, no resistance to doxorubicin was observed under FSS, the first such observation of a lack of resistance under these conditions. Finally, this study demonstrated the potential of photodynamic priming using benzoporphyrin derivative, a clinically approved photosensitizer that localizes in part to mitochondria and endoplasmic reticula, to enhance the efficacy of cisplatin, but not doxorubicin, thereby overcoming FSS-induced platinum resistance.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of photobiomodulation therapy on pain perception reduction associated with dental anesthetic infiltration injection: A systematic review and meta-analysis. 光生物调节疗法对减轻牙科麻醉剂浸润注射相关痛觉的疗效：系统回顾与荟萃分析。

IF 3.3 4区生物学

Photochemistry and Photobiology Pub Date : 2024-06-06 DOI: 10.1111/php.13977

Neda Hakimiha, Pantea Amiri, Fatemeh Sheibani, Zahra Razzaghi

{"title":"Efficacy of photobiomodulation therapy on pain perception reduction associated with dental anesthetic infiltration injection: A systematic review and meta-analysis.","authors":"Neda Hakimiha, Pantea Amiri, Fatemeh Sheibani, Zahra Razzaghi","doi":"10.1111/php.13977","DOIUrl":"https://doi.org/10.1111/php.13977","url":null,"abstract":"Dental anesthetic injections, a common source of patient discomfort, often deter individuals from seeking dental care. Recently, there has been a growing focus on photobiomodulation therapy (PBMT) and its potential role in pain reduction. This systematic review explored the efficacy of PBMT in alleviating pain associated with dental anesthetic infiltration injections. A systematic literature search of different databases was performed up to December, 2023 using specific search strategy to find eligible studies that assessed the impact of PBMT on pain during local anesthesia injections. Data extraction was done based on the inclusion/exclusion criteria. A total of 13 studies, involving 972 patients were included. The studies employed various PBMT parameters, including wavelengths, and energy densities. Meta-analyses revealed a significant reduction in pain with PBMT compared to controls (MD = -0.90, 95% CI: -1.36 to -0.44, and p = 0.0001), with notable heterogeneity (I2 = 91.79%). Stratified analyses by age demonstrated consistent pain reduction in both adults (MD = -0.59, 95% CI: -1.11 to -0.08, and p < 0.0001) and children (MD = -0.59, 95% CI: -1.11 to -0.08, and p = 0.025). In conclusion, it seems that PBMT using infrared diode lasers can effectively reduce injection pain in both pediatric and adult populations. Further research should focus on optimizing PBMT parameters for enhanced pain management during dental procedures.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0