Photochemistry and Photobiology最新文献_第10页

The use of a solar simulator device to standardize microbiological decontamination of contaminated water by solar disinfection by the SODIS and MB/SODIS protocols. 使用太阳能模拟装置，按照 SODIS 和 MB/SODIS 协议，通过太阳能消毒对受污染水体进行标准化微生物净化。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-23 DOI: 10.1111/php.14023

Janine Simas Cardoso Rurr, Juliana Patrão de Paiva, Raiane Rosales Diniz, Alvaro Augusto da Costa Leitao, Bryan Hudson Hossy, Nádia Campos de Oliveira Miguel, Claudia de Alencar Santos Lage

{"title":"The use of a solar simulator device to standardize microbiological decontamination of contaminated water by solar disinfection by the SODIS and MB/SODIS protocols.","authors":"Janine Simas Cardoso Rurr, Juliana Patrão de Paiva, Raiane Rosales Diniz, Alvaro Augusto da Costa Leitao, Bryan Hudson Hossy, Nádia Campos de Oliveira Miguel, Claudia de Alencar Santos Lage","doi":"10.1111/php.14023","DOIUrl":"https://doi.org/10.1111/php.14023","url":null,"abstract":"Consuming microbiologically-contaminated water is the primary cause of many water-borne diseases and deaths worldwide. Governments aim at providing drinking water for vulnerable populations, especially through low-cost interventions. Therefore, the solar disinfection (SODIS) of such pathogens provides a simple and cost-effective way to obtain good quality water. In this procedure, PET bottles are filled with contaminated water and exposed to sunlight for 1-2 days. To accelerate decontamination, methylene blue (MB) dye added as a photocatalyst, boosts singlet oxygen generation upon absorbing red-band sunlight. This study explores the use of a Sunlight Simulator (SSL) device to research and standardize the SODIS method with a vital dye as MB. PET bottles were filled with artificially-contaminated water with Streptococcus epidermidis and Deinococcus radiodurans Gram-positive bacteria, Escherichia coli and Salmonella typhimurium Gram-negative bacteria, or bacteriophage λ as well. In all experiments, 50 ng/mL MB ensued a synergistic lethal effect after SSL exposure. The results indicate that bacterial and bacteriophage inactivation can be achieved in shorter times with MB-SSL treatment compared to SSL without MB. In this sense, when compared to previous sunlight-SODIS results, the SSL source is a reliable tool to study the parameters of both SODIS and MB-SODIS protocols, and also a feasible tool to afford assays whenever there are unfavorable climate conditions.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the insecticide clothianidin on the photosynthetic electron transport chain in pea. 杀虫剂氯虫苯甲酰胺对豌豆光合电子传递链的影响

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-02 DOI: 10.1111/php.14018

Alena A Volgusheva, Jingrao Hao, Yanlin He, Elena R Lovyagina, Aleksey V Loktyushkin, Evgenia Yu Parshina, Oksana G Luneva, Adil A Baizhumanov, Sergei S Khruschev, Georgy V Maksimov, Andrew B Rubin

{"title":"Effect of the insecticide clothianidin on the photosynthetic electron transport chain in pea.","authors":"Alena A Volgusheva, Jingrao Hao, Yanlin He, Elena R Lovyagina, Aleksey V Loktyushkin, Evgenia Yu Parshina, Oksana G Luneva, Adil A Baizhumanov, Sergei S Khruschev, Georgy V Maksimov, Andrew B Rubin","doi":"10.1111/php.14018","DOIUrl":"https://doi.org/10.1111/php.14018","url":null,"abstract":"Clothianidin (CL) is a neonicotinoid insecticide widely used in crop protection against insect pests. However, its effects on photosynthesis remain largely unknown. Here, by investigating the influence of CL at the concentrations of 22 and 110 μg/L on the primary processes of photosynthesis, membrane fluidity and structural changes of pea chloroplasts, we located several primary binding sites of this pesticide. Similar dynamics were observed for both concentrations. However, statistically significant differences were only found at 110 μg/L for all methods used. The light saturated rate of linear electron flow decreased mainly due to the disturbance of electron flow on the acceptor side of photosystem II (PSII) associated with the appearance of QB-nonreducing centers and empty QB binding sites of PSII. The functioning of the donor side of PSII, the activity of photosystem I (PSI) and the maximum quantum yield of PSII photochemistry (Fv/Fm) were not found to be significantly altered. Increased membrane fluidity and structural alterations of the thylakoid membrane led to a decrease in the development of the proton gradient ΔрН and membrane energization processes.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of 625 nm light-emitting diode irradiation on preventing ER stress-induced apoptosis via GSK-3β phosphorylation in MC3T3-E1. 625 nm 发光二极管照射对通过 GSK-3β 磷酸化防止 ER 应激诱导 MC3T3-E1 细胞凋亡的影响

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2024-01-12 DOI: 10.1111/php.13906

Wenqi Fu, Guo Liu, Sun-Hun Kim, Byunggook Kim, Ok-Su Kim, Guowu Ma, Ying Yang, Danyang Liu, Siyu Zhu, Jae-Seok Kang, Okjoon Kim

{"title":"Effects of 625 nm light-emitting diode irradiation on preventing ER stress-induced apoptosis via GSK-3β phosphorylation in MC3T3-E1.","authors":"Wenqi Fu, Guo Liu, Sun-Hun Kim, Byunggook Kim, Ok-Su Kim, Guowu Ma, Ying Yang, Danyang Liu, Siyu Zhu, Jae-Seok Kang, Okjoon Kim","doi":"10.1111/php.13906","DOIUrl":"10.1111/php.13906","url":null,"abstract":"Prolonged endoplasmic reticulum (ER) stress contributes to cell apoptosis and interferes with bone homeostasis. Although photobiomodulation (PBM) might be used for ER stress-induced diseases, the role of PBM in relieving cell apoptosis remains unknown. During ER stress, glycogen synthase kinase-3β (GSK-3β) is critical; however, its functions in PBM remain uncertain. Thus, this study aimed to investigate the role of GSK-3β in 625 nm light-emitting diode irradiation (LEDI) relieving tunicamycin (TM)-induced apoptosis. Based on the results, pre-625 nm LEDI (Pre-IR) phosphorylated GSK-3β via ROS production. Compared with the TM group, Pre-IR + TM group reduced the phosphorylation of the α-subunit of eukaryotic translation initiation factor 2 (eIF-2α) and B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax)/Bcl-2 ratio through regulating GSK-3β. Furthermore, a similar tendency was observed between Pre-IR + TM and Pre-LiCl+TM groups in preventing TM-induced early and late apoptosis. In summary, this study suggests that the Pre-IR treatment in TM-induced ER stress is beneficial for preventing cell apoptosis via GSK-3β phosphorylation.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1408-1418"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of surface ligands on the photoinduced electron transfer rate and efficiency in ZnO quantum dots and graphene oxide assemblies. 表面配体对ZnO量子点和氧化石墨烯组件中光致电子转移速率和效率的影响。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2023-11-14 DOI: 10.1111/php.13881

Muhammad Adnan Khalid, Muhammad Mubeen, Maria Mukhtar, Poshmal Sumreen, Bushra Naz, Firdevs Aydın, Demet Asil, Azhar Iqbal

{"title":"Effect of surface ligands on the photoinduced electron transfer rate and efficiency in ZnO quantum dots and graphene oxide assemblies.","authors":"Muhammad Adnan Khalid, Muhammad Mubeen, Maria Mukhtar, Poshmal Sumreen, Bushra Naz, Firdevs Aydın, Demet Asil, Azhar Iqbal","doi":"10.1111/php.13881","DOIUrl":"10.1111/php.13881","url":null,"abstract":"Apart from biocompatibility, ZnO quantum dots (QDs) are considered to be an efficient luminescence material due to their low cost and high redox potential. Here, we report the synthesis of ZnO QDs by using five different functionalizing ligands like mercaptoacetic acid (MAA), 3-mercaptopropionic acid (MPA), octadecene (ODE), ethylene glycol (EG), and oleyl amine (OLA) and fabricate their assemblies with graphene oxide (GO). We investigate the role of functionalizing ligands as a surface modifier of ZnO QDs for their attachment to GO. The steady-state photoluminescence (SSPL) and time-resolved photoluminescence (TRPL) analyses demonstrate the photoluminescence (PL) quenching of ZnO QDs in ZnO QDs-GO assembly. The highest reduction in PL intensity is observed with ZnO QDs-GO assembly with EG as a surface functionalizing ligand. Cyclic voltammetry (CV) analysis confirms the feasibility of charge transfer from ZnO QDs to the GO. The maximum (79.43%) charge transfer efficiency (ECT) is observed in the case of ZnO-MAA-GO as compared to other assemblies. This means the thiol group-containing ligands facilitate charge transfer as compared to hydroxyl and amine group ligands. This leads to the conclusion that charge transfer in ZnO QDs-GO assemblies depends strongly on the nature of surface ligands.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1204-1213"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of traditional composite nonwovens with stable storage of light absorption transients and photodynamic antibacterial effect. 改性传统复合无纺布，稳定存储光吸收瞬态和光动力抗菌效果。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2024-03-25 DOI: 10.1111/php.13924

Ting-Ting Li, Bing-Bing Shou, Lu Yang, Hai-Tao Ren, Xian-Jin Hu, Jia-Horng Lin, Tao Cai, Ching-Wen Lou

{"title":"Modification of traditional composite nonwovens with stable storage of light absorption transients and photodynamic antibacterial effect.","authors":"Ting-Ting Li, Bing-Bing Shou, Lu Yang, Hai-Tao Ren, Xian-Jin Hu, Jia-Horng Lin, Tao Cai, Ching-Wen Lou","doi":"10.1111/php.13924","DOIUrl":"10.1111/php.13924","url":null,"abstract":"Combining photodynamic antimicrobials with nonwovens is prospective. However, common photosensitizers still have drawbacks such as poor photoactivity and the inability to charge. In this study, a photodynamic and high-efficiency antimicrobial protective material was prepared by grafting bis benzophenone-structured 4,4-terephthaloyl diphthalic anhydride (TDPA) photosensitizer, and antimicrobial agent chlorogenic acid (CA) onto spunbond-meltblown-spunbond (SMS) membranes. The charging rates for ·OH and H2O2 were 6377.89 and 913.52 μg/g/h. The light absorption transients structural storage remained above 69% for 1 month. High electrical capacity remained after seven cycles indicating its rechargeability and recyclability. The SMS/TDPA/CA membrane has excellent bactericidal performance when under illumination or lightless conditions, and the bactericidal efficiency of Escherichia coli and Staphylococcus aureus reached over 99%. The construction of self-disinfection textiles based on the photodynamic strategies proposed in this paper is constructive for expanding and promoting the application of textile materials in the medical field.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1328-1338"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An important step towards the comprehensive sun protection: Blue-light exposure inhibits DNA repair in reconstituted human skin and a broadband sunscreen avoids this inhibition. 向全面防晒迈出了重要一步：蓝光照射会抑制重组人体皮肤的 DNA 修复，而宽带防晒霜可避免这种抑制作用。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2024-06-03 DOI: 10.1111/php.13979

Paulo Newton Tonolli, Mauricio S Baptista

{"title":"An important step towards the comprehensive sun protection: Blue-light exposure inhibits DNA repair in reconstituted human skin and a broadband sunscreen avoids this inhibition.","authors":"Paulo Newton Tonolli, Mauricio S Baptista","doi":"10.1111/php.13979","DOIUrl":"10.1111/php.13979","url":null,"abstract":"The field of sun protection is quickly changing and the research article by Douki et al., published in the current issue of Photochemistry and Photobiology, reported key experimental data that will certainly help the development of better sun care products. Mutagenic photoproducts (CPDs, cyclobutane pyrimidine dimers and 6-4PPs, pyrimidine-6-4-pyrimidone photoproducts) were formed in the reconstructed human epidermis (RHE) by UVB (312 nm) irradiation, and their concentrations were detected by HPLC-MS/MS as a function of time after the UVB treatment. RHE had been previously exposed or not (control) to blue light (427 nm). Both CPDs and 6-4PPs were shown to last longer in blue-light irradiated RHE, proving the inhibition of the DNA repair by blue light exposure. This is a highly relevant information because sunscreens allow people to enjoy longer periods under the sun and consequently, to endure very high doses of blue light. The work also reported results obtained with RHEs previously treated with a sunscreen formulation containing a broadband filter that offers blue-light protection. Interestingly, authors observed that the DNA repair was not significantly inhibited in RHE previously treated with the sunscreen offering broadband protection. Readers will find a scientifically sound proof of the importance of blue-light protection in sun care products.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1527-1530"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells. 一种新的uva相关的cirbe2i介导HaCaT细胞的铁下垂。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2023-11-20 DOI: 10.1111/php.13885

Peng Yi, Yan Huang, Xin Zhao, Zhengshan Qin, Danli Zhu, Li Liu, Yuxi Zheng, Jianguo Feng, Menghong Long

{"title":"A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells.","authors":"Peng Yi, Yan Huang, Xin Zhao, Zhengshan Qin, Danli Zhu, Li Liu, Yuxi Zheng, Jianguo Feng, Menghong Long","doi":"10.1111/php.13885","DOIUrl":"10.1111/php.13885","url":null,"abstract":"Alternative splicing of precursor messenger RNA (pre-mRNA), including linear splicing and back splicing, produces multiple isoforms that lead to diverse cell fates in response to stimuli including ultraviolet radiation (UVR). Although UVR-induced linear gene splicing has been extensively studied in skin cells, the UVR-induced gene back-splicing events that lead to the production of circular RNAs (circRNAs) have not been thoroughly investigated. The present study used circRNA transcriptome sequencing to screen the differentially expressed circRNAs in human keratinocytes (HaCaT) after UVA irradiation. A total of 312 differentially expressed circRNAs were found in HaCaT cells post-UVR. Among the UVA-induced differentially expressed circRNAs, circUBE2I-a novel circRNA formed by exons 2-6 of the UBE2I gene-was the most significantly upregulated circRNA. RT-qPCR assay further confirmed the increase of circUBE2I level in HaCaT cells after UVA irradiation or H2O2 treatment. RNase R digestion experiment revealed the stability of circUBE2I. Overexpression of circUBE2I in keratinocytes induced ferroptosis after UVA or H2O2, preventable by the ferroptosis inhibitor ferrostatin-1. Our study provides new insights into the role of circular RNAs in UVA-induced skin cell damage and suggests that circUBE2I could be a therapeutic target in UVR-aroused ferroptosis in skin cells.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1365-1377"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The public-health significance of far-UVC-induced indoor ozone and its associated secondary chemistry. 远紫外线诱发的室内臭氧及其相关二次化学的公共卫生意义。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2023-11-30 DOI: 10.1111/php.13892

David J Brenner

{"title":"The public-health significance of far-UVC-induced indoor ozone and its associated secondary chemistry.","authors":"David J Brenner","doi":"10.1111/php.13892","DOIUrl":"10.1111/php.13892","url":null,"abstract":"There has been much recent interest in whole-room far-UVC (wavelength around 222 nm) to markedly and safely reduce overall levels of airborne pathogens in occupied indoor locations. Far-UVC light produces very low levels of ozone-in real-world scenarios induced ozone levels of less than 10 ppb, and much less in moderately or well-ventilated rooms compliant with US far-UVC dose recommendations, and very much less in rooms compliant with international far-UVC dose standards. At these very low ozone levels, there is no epidemiological evidence of increased health risks from any of the very large outdoor ozone studies, whether from ozone alone or from ozone plus associated pollutants. Indoors, at the low ozone concentrations of relevance here, ozone does not react rapidly enough with preexisting airborne volatile organic compounds to compete with even extremely low levels of room ventilation, so significant ozone-induced ultrafine particle production is very unlikely. Direct measurements in real-life room scenarios are consistent with these conclusions. A potential exception is the cleaning material limonene, which has an unusually high ozone interaction cross-section; in the far-UVC context, turning off far-UVC lights during cleaning with limonene products would be reasonable.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1186-1190"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between sun exposure, skin pH, and epidermal permeability in pregnancy: A longitudinal observational study. 孕期日晒、皮肤 pH 值和表皮渗透性之间的关系：一项纵向观察研究。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2024-02-09 DOI: 10.1111/php.13920

Rachel Stevens, Shelley Gorman, Diana Arabiat, Claus T Christophersen, Debra J Palmer

{"title":"Associations between sun exposure, skin pH, and epidermal permeability in pregnancy: A longitudinal observational study.","authors":"Rachel Stevens, Shelley Gorman, Diana Arabiat, Claus T Christophersen, Debra J Palmer","doi":"10.1111/php.13920","DOIUrl":"10.1111/php.13920","url":null,"abstract":"Little is known about how sun exposure may affect the maternal skin barrier during pregnancy when many hormonal and physiological changes occur. In this longitudinal observational study, 50 pregnant women were recruited at 18-24 weeks' gestation, 25 in summer-autumn, and 25 in winter-spring. At three time points in pregnancy at 18-24, 28-30, and 36-38 weeks' gestation, participants completed a validated sun exposure questionnaire and had skin permeability and surface pH measured on the volar forearm. We identified an association between increased sun exposure and increased skin permeability at 18-24 weeks' gestation (β = 0.85, p = 0.01). Lower transepidermal water loss (decreased skin permeability), mean = 12.1 (SD = 5.1) at 28-30 weeks' gestation was observed, compared to mean = 12.6 (SD = 4.0) at 18-24 weeks' and mean = 13.7 (SD = 8.5) at 36-38 weeks' gestation (n = 27, β = -1.83, p = 0.007). Higher skin pH readings, mean = 5.80 (SD = 0.58) were found at 28-30 weeks' gestation, compared to mean = 5.25 (SD = 0.62) at 18-24 weeks' and mean = 5.47 (SD = 0.57) at 36-38 weeks' gestation (n = 27, β = 0.40, p = 0.004). These gestational fluctuations remained after adjusting for Fitzpatrick skin type, season, and sun exposure. We observed gestational fluctuations in both skin permeability and skin pH, with 28-30 weeks' gestation being a significant point of difference compared to mid- and late-pregnancy periods.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1519-1526"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139712845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of isoquercitrin on UVB-induced injury in HaCaT cells and mice skin through anti-inflammatory, antioxidant, and regulation of MAPK and JAK2-STAT3 pathways. 异槲皮素通过抗炎、抗氧化以及调节 MAPK 和 JAK2-STAT3 通路，对紫外线诱导的 HaCaT 细胞和小鼠皮肤损伤具有保护作用。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-09-01 Epub Date: 2024-02-09 DOI: 10.1111/php.13919

Yingyan Li, Yunge Ma, Yike Yao, Guohua Ru, Chong Lan, Liyan Li, Tao Huang

{"title":"Protective effect of isoquercitrin on UVB-induced injury in HaCaT cells and mice skin through anti-inflammatory, antioxidant, and regulation of MAPK and JAK2-STAT3 pathways.","authors":"Yingyan Li, Yunge Ma, Yike Yao, Guohua Ru, Chong Lan, Liyan Li, Tao Huang","doi":"10.1111/php.13919","DOIUrl":"10.1111/php.13919","url":null,"abstract":"Natural products are favored in the study of skin photodamage protection recently. Isoquercetin, namely 3-O-glucoside of quercetin, can be isolated from various plant species. In present research, the protective effect of isoquercitrin on UVB-induced injury in cells and mice skin were investigated. Our study reveals that 400 μM of isoquercitrin exhibits the best viability on UVB-irradiated HaCaT cells, and beneficial effects against oxidative stress UVB-induced in skin tissue by decreasing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and simultaneously enhancing the activity of superoxide dismutase (SOD). Additionally, isoquercitrin was identified as an anti-inflammatory agent by reducing the level of COX-2 by Western blot analysis, and inflammatory cytokines such as IL-6, IL-1β, and TNF-α by ELISA, and UVB-induced epidermal thickening evidenced by H&E staining. It also effectively prevented UVB-induced collagen fibers from degradation identified by Masson staining. Isoquercitrin significantly inhibited MAPK pathway by downregulating the levels of AP-1, MMP-1, MMP-3, phospho-p38, phospho-JNK, phospho-ERK, cleaved caspase-9, cleaved caspase-3, and JAK2-STAT3 pathway by western blot analysis. In conclusion, isoquercitrin pretreatment protected mice skin from UVB irradiation-induced injury effectively, and the underlying mechanism may involve MAPK and JAK2-STAT3 signaling pathways.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1507-1518"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139712846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0