Photochemistry and Photobiology最新文献_第9页

Expression profiles and functional analysis of transfer RNA-derived small RNAs (tsRNAs) in photoaged human dermal fibroblasts. 转运核糖核酸衍生的小核糖核酸（tsRNA）在光老化的人类真皮成纤维细胞中的表达谱和功能分析。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-08-30 DOI: 10.1111/php.14015

Amin Yao, Yu Zhang, Mengting Ouyang, Lei Wen, Wei Lai

{"title":"Expression profiles and functional analysis of transfer RNA-derived small RNAs (tsRNAs) in photoaged human dermal fibroblasts.","authors":"Amin Yao, Yu Zhang, Mengting Ouyang, Lei Wen, Wei Lai","doi":"10.1111/php.14015","DOIUrl":"10.1111/php.14015","url":null,"abstract":"Transfer RNA-derived small RNAs (tsRNAs) refer to a newly established family of non-coding RNAs that regulate a diverse set of biological processes. However, the function of tsRNAs in skin photoaging remains unclear. This research aims to investigate the potential correlation between tsRNAs and skin photoaging. Human dermal fibroblasts (HDFs) were irradiated with UVA at 10 J/cm2 once a day lasting for 14 days, resulting in the establishment of a photoaging model induced by UVA. To identify the expression profiles and functions of tsRNAs, tsRNA sequencing and bioinformatics analysis were conducted. qPCR was employed to validate the results of differentially expressed (DE) tsRNAs. A total of 34 tsRNAs exhibited significant differential expression between the UVA and control groups (n = 3), with nine upregulated and 25 downregulated (log2 fold change >1.5, p-value <0.05). Six tsRNAs were selected at random and validated by qRT-PCR. The enrichment analysis of DE tsRNAs target genes indicated that the dysregulated tsRNAs appeared to be connected with cell cycle, DNA replication and the AGE-RAGE signaling pathway. The expression of tsRNAs was found to be aberrant in UVA-HDF. These findings provide insights into the UVA-induced damage and potential target genes for skin photoaging.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"505-516"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the ESIPT process in benzoxazole fluorophores within polymeric matrices through theory and experiment. 通过理论和实验揭示聚合物基质中苯并噁唑荧光团的 ESIPT 过程。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-06-26 DOI: 10.1111/php.13991

Luís Gustavo Teixeira Alves Duarte, Emmanuel Santos Moraes, Priscila Sayoko Silva Wakabayashi, Lilian Camargo da Luz, Rodrigo Cercená, Eduardo Zapp, Teresa Dib Zambon Atvars, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch

{"title":"Revealing the ESIPT process in benzoxazole fluorophores within polymeric matrices through theory and experiment.","authors":"Luís Gustavo Teixeira Alves Duarte, Emmanuel Santos Moraes, Priscila Sayoko Silva Wakabayashi, Lilian Camargo da Luz, Rodrigo Cercená, Eduardo Zapp, Teresa Dib Zambon Atvars, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch","doi":"10.1111/php.13991","DOIUrl":"10.1111/php.13991","url":null,"abstract":"The impact of the polymeric matrix on the photophysical characteristics of monomeric dyes responsive to excited-state intramolecular proton transfer (ESIPT) was investigated through UV-Vis absorption as well as steady-state and time-resolved emission spectroscopies. For this purpose, two benzoxazole monomers (M1 and M2) with acryloyl groups at different positions in their molecular structures were employed to facilitate covalent bonding within a styrene chain. Our findings reveal significant variations in their excited-state properties due to the proximity of the acryloyl groups, which affects the energy barrier of the ESIPT reaction, the emission wavelength, and the balance between the normal and tautomeric forms. The experimental results were corroborated through theoretical investigations at the DFT/TDDFT level, specifically using the B3LYP-D3/def2-TZVP methodology. Three notable observations emerged: donor/acceptor groups at the meta/para positions induced electron distribution changes, causing red-shifted emission for M2; in the polymer film, particularly in PM1, intramolecular hydrogen bond deactivation favored N* emission over T* emission; and the zwitterionic character of the T* species. This study underscores the advantages of functionalization in polymers, which can lead to colorless films and prevalent N* or T* emission, and contributes valuable insights into molecular design strategies for tailoring the photophysical properties of polymeric materials.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"290-301"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-free functionalized carbon nitride as a photocatalyst driven by sunlight for acetal synthesis and selective regeneration of NAD(P)H cofactor. 无金属功能化氮化碳作为光催化剂，在阳光驱动下进行缩醛合成和 NAD(P)H 辅因子的选择性再生。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-08-16 DOI: 10.1111/php.14011

Shaifali Mishra, Rajesh K Yadav, Dinesh K Mishra, Kuldeep Kumar, Navneet Kumar Gupta, Kuldeep Singh, Satyaveer Gothwal, Jin-OoK Baeg

{"title":"Metal-free functionalized carbon nitride as a photocatalyst driven by sunlight for acetal synthesis and selective regeneration of NAD(P)H cofactor.","authors":"Shaifali Mishra, Rajesh K Yadav, Dinesh K Mishra, Kuldeep Kumar, Navneet Kumar Gupta, Kuldeep Singh, Satyaveer Gothwal, Jin-OoK Baeg","doi":"10.1111/php.14011","DOIUrl":"10.1111/php.14011","url":null,"abstract":"Nicotinamide Adenine Dinucleotide Phosphate (NAD(P)H) plays an important role in numerous biologically significant redox reactions. The photochemical restoration of its oxidized form (NAD(P)+) under physiological conditions is intriguing in the context of integrated photo and catalysis. Herein, we report the functionalized graphitic carbon-based solar light active photocatalyst by doping boron and fluorine in the native graphitic carbon nitride (GCN) (nonfunctionalized) for the regeneration of enzymatically visible light active coenzyme and in photo-acetalization reactions. The metal-free functionalized photocatalyst systems such as BFGCN-x leads to higher yield NADH and NADPH regeneration. They are also capable of catalyzing acetal reactions in the absence of any Lewis and Bronsted acids. The current research endeavor provides the advancement and the application of functionalized GCN-based photocatalysts for NADH (61.89%), NADPH (59.84%) regeneration, and photo-acetalization reactions.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"471-482"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis to evaluate the effects of solar exposure and a broad-spectrum SPF50+ sunscreen on markers of skin barrier function in a skin ecosystem model. 在皮肤生态系统模型中，通过多组学分析评估日光照射和广谱 SPF50+ 防晒霜对皮肤屏障功能标志物的影响。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.1111/php.14001

Carine Jacques, Emilien L Jamin, Anais Noustens, Christophe Lauze, Isabelle Jouanin, Gautier Doat, Laurent Debrauwer, Sandrine Bessou-Touya, Eggert Stockfleth, Hélène Duplan

{"title":"Multi-omics analysis to evaluate the effects of solar exposure and a broad-spectrum SPF50+ sunscreen on markers of skin barrier function in a skin ecosystem model.","authors":"Carine Jacques, Emilien L Jamin, Anais Noustens, Christophe Lauze, Isabelle Jouanin, Gautier Doat, Laurent Debrauwer, Sandrine Bessou-Touya, Eggert Stockfleth, Hélène Duplan","doi":"10.1111/php.14001","DOIUrl":"10.1111/php.14001","url":null,"abstract":"Sun exposure induces major skin alterations, but its effects on skin metabolites and lipids remain largely unknown. Using an original reconstructed human epidermis (RHE) model colonized with human microbiota and supplemented with human sebum, we previously showed that a single dose of simulated solar radiation (SSR) significantly impacted the skin metabolome and microbiota. In this article, we further analyzed SSR-induced changes on skin metabolites and lipids in the same RHE model. Among the significantly altered metabolites (log2-fold changes with p ≤ 0.05), we found several natural moisturizing factors (NMFs): amino acids, lactate, glycerol, urocanic acid, pyrrolidone carboxylic acid and derivatives. Analyses of the stratum corneum lipids also showed that SSR induced lower levels of free fatty acids and higher levels of ceramides, cholesterols and its derivatives. An imbalance in NMFs and ceramides combined to an increase of proinflammatory lipids may participate in skin permeability barrier impairment, dehydration and inflammatory reaction to the sun. Our skin model also allowed the evaluation of an innovative ultraviolet/blue light (UV/BL) broad-spectrum sunscreen with a high sun protection factor (SPF50+). We found that using this sunscreen prior to SSR exposure could in part prevent SSR-induced alterations in NMFs and lipids in the skin ecosystem RHE model.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"373-385"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of rice fermentation and its bioactive components on UVA-induced oxidative stress and senescence in dermal fibroblasts. 大米发酵及其生物活性成分对 UVA 诱导的真皮成纤维细胞氧化应激和衰老的影响

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-18 DOI: 10.1111/php.14003

Yu Li, Miao Guo, Li Li, Fan Yang, Lidan Xiong

{"title":"Effects of rice fermentation and its bioactive components on UVA-induced oxidative stress and senescence in dermal fibroblasts.","authors":"Yu Li, Miao Guo, Li Li, Fan Yang, Lidan Xiong","doi":"10.1111/php.14003","DOIUrl":"10.1111/php.14003","url":null,"abstract":"Photoaging, caused by ultraviolet (UV) radiation, is characterized by the senescence of skin cells and reduction of collagens. Although rice fermentation is widely used in the cosmetics, its impact on skin photoaging is still not well understood. Herein, we investigated the possible effectiveness of Maifuyin, a fermented rice product, and its components, succinic acid (SA), and choline, for safeguarding UVA-exposed human dermal fibroblasts (HDFs) against photoaging. In this study, the effects of Maifuyin, SA, and choline on UVA-induced cell death and senescence in fibroblasts were evaluated in cell counting kit-8 (CCK-8), expression of β-galactosidase (β-GAL), and matrix metalloproteinases (MMP)-1. To identify oxidative stress, the investigation focused on reactive oxygen species, glutathione, superoxide dismutase, and malondialdehyde. Additionally, a mRNA sequencing technology (RNA-seq) was applied to study the underlying mechanisms of these components on UVA-induced photoaging. Meanwhile, the level of C-X-C motif chemokine ligand 2 (CXCL2) in the cell supernatant was confirmed to assess the autocrine chemokine level. To reassess the involvement of CXCL2, the expression of β-GAL was evaluated in fibroblasts treated with or without CXCL2. The results indicated that 1 mg/mL Maifuyin and SA inhibited UVA-induced senescence in fibroblasts, MMP-1 expression, and oxidative damage. The RNA-seq revealed 1 mg/mL Maifuyin and SA might be recruited chemokine CXCLs to inhibit MMPs production and fibroblast senescence via TNFα, MAPK, and NF-κB pathways. ELISA results showed a significant reduction of autocrine CXCL2 in UVA-irradiated HDFs by pretreating Maifuyin and SA. The β-GAL staining assay revealed that CXCL2 treatment increased β-GAL activity, while the administration of Maifuyin and SA counteracted this effect in HDFs. These results highlighted the potential use of Maifuyin and SA as promising candidates for anti-photoaging applications.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"392-403"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultraviolet irradiation benefits left ventricular hypertrophy and mitochondrial morphology of cardiomyocytes in hypertensive rats. 紫外线照射有益于高血压大鼠左心室肥厚和心肌细胞线粒体形态。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-23 DOI: 10.1111/php.14002

Hiroki Shibata, Akiko Noda, Yuji Nishizawa, Atsuki Ito, Takahiro Okumura, Katsunori Hashimoto, Kozue Takeda, Kimiaki Katanosaka, Fumihiko Yasuma, Shiyong Wu

{"title":"Ultraviolet irradiation benefits left ventricular hypertrophy and mitochondrial morphology of cardiomyocytes in hypertensive rats.","authors":"Hiroki Shibata, Akiko Noda, Yuji Nishizawa, Atsuki Ito, Takahiro Okumura, Katsunori Hashimoto, Kozue Takeda, Kimiaki Katanosaka, Fumihiko Yasuma, Shiyong Wu","doi":"10.1111/php.14002","DOIUrl":"10.1111/php.14002","url":null,"abstract":"Insufficient exposure to sunlight increases the risk of cardiovascular diseases. Hypertensive left ventricular (LV) hypertrophy exacerbates the risks of myocardial ischemia, ventricular arrhythmias, sudden cardiac death, and heart failure. This study aimed to determine the effects of ultraviolet (UV) irradiation on LV hypertrophy and mitochondrial morphology. Eighteen 7-week-old Dahl salt-sensitive (Dahl S) rats were categorized into three groups (n = 6 each) and fed sodium chloride (NaCl) diets, as follows: UV-irradiated [UVB+A (+), 8% NaCl], non-UV-irradiated [UV (-), 8% NaCl], and control [UV (-), 0.3% NaCl]. UV irradiation was administered at a low intensity of 100 mJ/cm2 for 6 days per week. Echocardiography and mitochondrial analyses were performed to evaluate LV hypertrophy and cardiomyocytes, and skin tissues were stained with hematoxylin and eosin to assess the pathological abnormalities at 12 weeks of age. LV mass was significantly reduced in the UVB+A (+) and control groups compared to that in the UV (-) group. Mitochondrial structural abnormalities in cardiomyocytes were observed only in the UV (-) group, but not in the UVB+A (+) or control group. Pathological skin abnormalities were not observed in any of the three groups. These findings suggest the potential benefits of UV irradiation in hypertensive models.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"386-391"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking acetylcholinesterase inhibitor pesticides in the environment using the rapid transient of chlorophyll fluorescence. 利用叶绿素荧光快速瞬态跟踪环境中乙酰胆碱酯酶抑制剂农药。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-02-17 DOI: 10.1111/php.14080

Ivana López Valiño, Gonzalo Dieguez Gaviola, Virginia Emilse Diz, Graciela Alicia González, María Gabriela Lagorio, Gabriela Beatriz Cordon

{"title":"Tracking acetylcholinesterase inhibitor pesticides in the environment using the rapid transient of chlorophyll fluorescence.","authors":"Ivana López Valiño, Gonzalo Dieguez Gaviola, Virginia Emilse Diz, Graciela Alicia González, María Gabriela Lagorio, Gabriela Beatriz Cordon","doi":"10.1111/php.14080","DOIUrl":"https://doi.org/10.1111/php.14080","url":null,"abstract":"Several home pesticides are organophosphorus compounds. These compounds inhibit the enzyme acetylcholinesterase, causing harmful effects on the health of biota. Through this research, the usefulness of Glycine max (soybean) and Cichorium intybus (chicory) plants as sentinels of organophosphorus compounds in the environment was successfully tested. Different concentrations of the insecticide chlorpyrifos were tried out. Damage to plants at the photosynthetic apparatus level was evaluated by measuring the high temporal resolution variable chlorophyll fluorescence (OJIP test). Several parameters derived from this test indicated a high level of damage in both species even at the mean dose recommended for use in the field. However, a few parameters did not consistently reflect damage in leaves. A drop in the values of the maximum fluorescence (FM), the quantum yield of electron transport flux, transport between quinones A and B (ET0/ABS) and the maximal quantum yield of PSII (TR0/ABS) could alert us about the presence of organophosphates in the environment. An increase in the dissipated energy flux per reaction center (DI0/RC) values was also observed. The species showed different sensitivities, with soybean plants being the most sensitive. The OJIP transient thus becomes a valuable rapid, non-destructive tool for biomonitoring this class of pesticides in the environment.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GOUTERMAN - A module for simulations of tetrapyrrole optical spectra. 一个模拟四吡咯光谱的模块。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-02-17 DOI: 10.1111/php.14057

Hai Du, Masahiko Taniguchi, James R Diers, Christine Kirmaier, David F Bocian, Jonathan S Lindsey, Dewey Holten

{"title":"GOUTERMAN - A module for simulations of tetrapyrrole optical spectra.","authors":"Hai Du, Masahiko Taniguchi, James R Diers, Christine Kirmaier, David F Bocian, Jonathan S Lindsey, Dewey Holten","doi":"10.1111/php.14057","DOIUrl":"https://doi.org/10.1111/php.14057","url":null,"abstract":"Tetrapyrrole macrocycles comprise the pigments of life (heme, chlorophylls, etc.) and together with synthetic analogues also find wide use in materials chemistry and the life sciences. The distinct colors of the various macrocycles are essential features. A time-honored approach for understanding the electronic spectra entails analyzing the impact of molecular composition on the relative energies of the four frontier molecular orbitals (MOs) of these 18-π annulenes. While first introduced by Prof. Martin Gouterman in 1959, use of the four-orbital model has been largely conceptual. Here, a computational module (GOUTERMAN) is introduced that takes as input the energies of the four MOs, provides user control over key parameters (configuration-interaction energies, dipole strengths, spectral widths), and outputs simulated absorption spectra. The energies of the MOs can be calculated independently (e.g., from density functional theory) or drawn from a small database that is provided. The MO energies and key parameters can be toggled and spectral changes viewed. The GOUTERMAN module is available in PhotochemCAD as a tool for both specialists and non-specialists to visualize, via hands-on experience, the connections between the structural and spectral properties of the tetrapyrrole chromophores found ubiquitously in Nature and used widely in research.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized LED phototherapy induces ROS-mediated membrane damage in Trichophyton rubrum for effective onychomycosis treatment. 优化的LED光疗诱导红毛癣ros介导的膜损伤，有效治疗甲真菌病。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-02-17 DOI: 10.1111/php.14079

Angze Li, Yi Ren, Zhenjian Peng, Shangfeng Liu, Muqing Liu

{"title":"Optimized LED phototherapy induces ROS-mediated membrane damage in Trichophyton rubrum for effective onychomycosis treatment.","authors":"Angze Li, Yi Ren, Zhenjian Peng, Shangfeng Liu, Muqing Liu","doi":"10.1111/php.14079","DOIUrl":"https://doi.org/10.1111/php.14079","url":null,"abstract":"Onychomycosis, predominantly induced by Trichophyton rubrum, is a pervasive nail disorder within dermatology known for its high relapse rates and suboptimal patient adherence to treatment regimens. While photomedicine has emerged as a promising therapeutic modality, efficiency reductions are common due to deck obstruction in conventional light therapy. The spectral flexibility of LEDs offers a compelling solution, allowing for deeper deck penetration while maintaining efficacy. We have developed an advanced LED system with optimized optical parameters and have elucidated the antimicrobial mechanisms underlying this technology. Our research shows that an optimal wavelength of 405 nm, an energy density of 396 J/cm2, and an average light intensity of 140 mW/cm2 demonstrate superior efficacy in treating onychomycosis. The antifungal mechanism of our pulsed LED system involves the induction of reactive oxygen species (ROS) within fungal mycelia, ultimately resulting in membrane damage. These insights highlight the potential of LED lighting systems as a novel antimicrobial strategy, offering a promising avenue for the treatment of onychomycosis.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the naphthylene linker on the J-aggregation abilities of chlorophyll-a derivatives. 萘链对叶绿素-a 衍生物 J-聚集能力的影响。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-02-13 DOI: 10.1111/php.14076

Yuma Hisahara, Takeo Nakano, Hitoshi Tamiaki

引用次数: 0