Photochemistry and Photobiology最新文献

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Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes. 光动力疗法作为一种潜在的方法来防止真菌传播与使用气管内管。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-12-22 DOI: 10.1111/php.14054
Gabriel Grube Dos Santos, Amanda Cristina Zangirolami, Maria Luiza Ferreira Vicente, Vanderlei Salvador Bagnato, Kate Cristina Blanco
{"title":"Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes.","authors":"Gabriel Grube Dos Santos, Amanda Cristina Zangirolami, Maria Luiza Ferreira Vicente, Vanderlei Salvador Bagnato, Kate Cristina Blanco","doi":"10.1111/php.14054","DOIUrl":"https://doi.org/10.1111/php.14054","url":null,"abstract":"<p><p>Fungal infections related to biofilm formation on medical devices, such as endotracheal tubes (ETTs), pose significant health risks, especially during intubation procedures where fungi like Candida spp. can migrate into the lower respiratory tract. This study explores the use of Photodynamic Therapy (PDT) to prevent fungal cell migration from ETT surfaces to lungs, focusing on the role of curcumin as a photosensitizer. ETTs were coated with varying concentrations of curcumin, and biofilm formation was measured after applying PDT with a 50 J/cm<sup>2</sup> irradiation dose. The study found that ETTs functionalized with a one-third concentration of CUR reduced biofilm formation by 1.78 Log, significantly lowering microbial load and potentially decreasing hospital-acquired infections. Confocal fluorescence microscopy confirmed that PDT damaged the biofilm's extracellular matrix and caused detachment of dead fungal cells. Moreover, the fluorescence analysis reveals the photodegradation behavior of the photosensitizer within the tube, providing critical insights into its stability and durability, which are essential for evaluating the long-term applicability of these tubes in clinical settings. These results suggest PDT as a promising strategy to reduce fungal infections in high-risk patients, offering potential for future clinical application in preventing device-associated infections.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggregation assisted enhancement of singlet oxygen generation by 4-ethynylphenyl substituted porphyrin photosensitizer for photodynamic therapy. 聚集体辅助增强4-乙基苯基取代卟啉光敏剂光动力治疗的单线态氧生成。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-12-20 DOI: 10.1111/php.14049
Sekar Monisha, Thangavel Myithili, Samuthirakani Ajithkumar, Kumaresan Sudharsan, Thangaraj Keerthana, Baskaran Sarikalakshmi, Mohan Pandi, Palanisamy Kalimuthu
{"title":"Aggregation assisted enhancement of singlet oxygen generation by 4-ethynylphenyl substituted porphyrin photosensitizer for photodynamic therapy.","authors":"Sekar Monisha, Thangavel Myithili, Samuthirakani Ajithkumar, Kumaresan Sudharsan, Thangaraj Keerthana, Baskaran Sarikalakshmi, Mohan Pandi, Palanisamy Kalimuthu","doi":"10.1111/php.14049","DOIUrl":"https://doi.org/10.1111/php.14049","url":null,"abstract":"<p><p>Modulating the photophysical properties of photosensitizers is an effective approach to enhance singlet oxygen generation for photodynamic therapy. Porphyrins are the most widely used photosensitizers due to their biocompatible nature. Aggregation-induced emission (AIE) characteristics of photosensitizers are one of the advantageous features that will enhance fluorescence, intersystem crossing, and efficient triplet state generation. Herein, we demonstrate two glycosylated porphyrin photosensitizers, ZnGEPOH (with two ethynyl groups) and ZnGPOH (without two ethynyl groups), which exhibit AIE. Detailed studies revealed that ZnGEPOH exhibited a two-fold increase in singlet oxygen production than ZnGPOH due to AIE. The photo-cytotoxicity of ZnGPOH and ZnGEPOH were evaluated using cancer cell lines A549 and AGS. ZnGEPOH shows superior photo-cytotoxicity with cell viability of 21% and 19% for A549 and AGS, respectively, at 250 μg/mL concentration in 48 h. Moreover, ZnGEPOH exhibits minimal photo-cytotoxicity towards the control cell line HEK 293.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ocular safety of 222-nm far-ultraviolet-c full-room germicidal irradiation: A 36-month clinical observation. 222nm远紫外-c全室杀菌照射眼安全性:36个月临床观察。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-12-10 DOI: 10.1111/php.14052
Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Sho Ichioka, Ichiya Sano, Katsunori Hara, Masaki Tanito
{"title":"Ocular safety of 222-nm far-ultraviolet-c full-room germicidal irradiation: A 36-month clinical observation.","authors":"Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Sho Ichioka, Ichiya Sano, Katsunori Hara, Masaki Tanito","doi":"10.1111/php.14052","DOIUrl":"https://doi.org/10.1111/php.14052","url":null,"abstract":"<p><p>The ocular safety of 222-nm far-ultraviolet-C (UV-C) irradiation, widely recognized for its germicidal properties, was evaluated in a clinical setting to assess its long-term health effects on the human eye. This prospective observational study involved a 36-month follow-up of physicians working in an ophthalmic examination room equipped with 222-nm UV-C lamps. Initially, a 12-month observation showed no signs of acute or chronic ocular damage. To further substantiate these findings, the study period was extended to 36 months, during which four participants underwent regular ocular examinations, including assessments of visual acuity, refractive error, and corneal endothelial cell density. The irradiation dose was meticulously controlled to remain within the previous threshold limit of 22 mJ/cm<sup>2</sup> over an 8-h period, as advised by the ACGIH prior to 2022. Results indicated no significant changes in these parameters, suggesting no clinically significant ocular hazards associated with prolonged exposure to 222-nm UV-C irradiation under real-world conditions. Additionally, no delayed side effects, such as pterygium, keratopathies, or cataracts, were observed. Our study supports the safe use of 222-nm UV-C for microbial disinfection in occupied environments and provides a robust foundation for updated safety guidelines.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
520 nm and 660 nm light-emitting diodes modulates pancreatic development and beta cell functions in zebrafish embryos. 520nm和660nm发光二极管调节斑马鱼胚胎胰腺发育和β细胞功能。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-12-10 DOI: 10.1111/php.14050
Ünsal Veli Üstündağ, İsmail Ünal, Derya Cansız, Merih Beler, Naveen Krishna Kanagaraj, Amrish Rajendra Kumar, Ravindra Peravali, Ebru Emekli-Alturfan
{"title":"520 nm and 660 nm light-emitting diodes modulates pancreatic development and beta cell functions in zebrafish embryos.","authors":"Ünsal Veli Üstündağ, İsmail Ünal, Derya Cansız, Merih Beler, Naveen Krishna Kanagaraj, Amrish Rajendra Kumar, Ravindra Peravali, Ebru Emekli-Alturfan","doi":"10.1111/php.14050","DOIUrl":"https://doi.org/10.1111/php.14050","url":null,"abstract":"<p><p>Green and Red LEDs increase insulin production, but their comparative effects on pancreatic and beta cell development are unclear. Zebrafish embryos were divided into three groups: Control (n = 60), Green (G) (n = 60), and Red (R) (n = 60), then irradiated for three days (14 hours/day) with 0.5 W/cm<sup>2</sup> G (λpeak = 520 nm, 180 mA) and R (λpeak = 660 nm, 210 mA). At the end of 72 h, pancreatic and beta cells, circadian rhythm, and oxidative stress gene were analyzed using RT-PCR. Malondialdehyde, nitric oxide, superoxide dismutase, and glutathione levels were also evaluated. In the Red group, pancreatic area increased by ~97.13% compared to the Control group and by approximately ~62.16% compared to the G group (both p < 0.0001), and no significant difference in beta cell area (p = 0.964). G group insulin expression increased 2.31-fold compared to R group (p < 0.0001). Red LED treatment increased MDA levels (p < 0.001), oxidative stress (fth1b, nqo1) (p < 0.0001), and per1b during the photophase (p < 0.0001) compared to G group. R LED treatment increases oxidative stress and disrupts circadian rhythm, leading to reduced insulin secretion. The positive effects of G LED treatment have potential for metabolic syndrome, diabetes, and pancreatic diseases.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caviar extract inhibits skin photoaging by activating skin stem cells through NF-κB/MMPs/COL17A1 axis. 鱼子酱提取物通过NF-κB/MMPs/COL17A1轴激活皮肤干细胞抑制皮肤光老化。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-12-03 DOI: 10.1111/php.14039
Younan Kou, Wuyan Guo, Yun Wang, Changhua Kou, Bo Zhang
{"title":"Caviar extract inhibits skin photoaging by activating skin stem cells through NF-κB/MMPs/COL17A1 axis.","authors":"Younan Kou, Wuyan Guo, Yun Wang, Changhua Kou, Bo Zhang","doi":"10.1111/php.14039","DOIUrl":"https://doi.org/10.1111/php.14039","url":null,"abstract":"<p><p>Ultraviolet radiations (UVR) produce harmful entities and reactive oxygen species (ROS) in skin cells, leading to skin photoaging. Caviar extract (CE) showed outstanding effects in delaying skin aging, but the underlying mechanism remains largely unknown. In this study, we prepared CE with acid protease and examined the anti-skin photoaging effects. The results showed that CE performed no cytotoxicity to HaCaT cells. For antioxidant properties, the EC50 values of DPPH and ABTS radical scavenging activity for CE were 1.27 and 5.20 mg/mL, respectively. It significantly reduced NF-κB, MMP-3 and MMP-9 protein expression levels, and increased IκB and TIMP-1 expression level in UVA-irradiated HaCaT cells. In the skin aging mice model, CE reduced the degree of UV-induced skin photoaging. Histological study confirmed that CE can ameliorate the adverse effects of UV exposure on the skin. Moreover, we found that CE could enhance the activities of Superoxide dismutase (SOD), and increased the contents of hydroxyproline (HYP) in photoaged mice skin. And CE elevated the protein expression level of COL17A1, KRT10, and KRT14 in mice skin. Taken together, our results bright systemic and new insights of CE into preventing UV-induced skin photoaging.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals. 短光信号诱导含羞草运动细胞的快速渗透收缩反应。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-11-29 DOI: 10.1111/php.14046
Gabriel Roblin, Christelle Moyen, Pierrette Fleurat-Lessard, Fabienne Dédaldéchamp
{"title":"Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals.","authors":"Gabriel Roblin, Christelle Moyen, Pierrette Fleurat-Lessard, Fabienne Dédaldéchamp","doi":"10.1111/php.14046","DOIUrl":"https://doi.org/10.1111/php.14046","url":null,"abstract":"<p><p>The Mimosa pudica leaf has motor organs allowing movements driven by cell osmotic changes in the parenchyma cells in response to various stimuli. Short white light pulses induce rapid and large seismonastic-like movements (denoted \"photostimulation\") of the primary pulvini in various leaves within 120 s after the onset of light. An early event recorded is a wavelength-related modification of the plasma membrane difference: potential depolarization under white, blue, green, and red wavelengths, and hyperpolarization under far red wavelengths (and also in darkness). The photoreactivity of the pulvini is controlled by a circadian rhythm and modulated by the applied diurnal photoperiod cycle (photophase ranging from 6 to 18 h). The reactivity varied among plants and even between leaves on the same plant. The level of reactivity is related to the photon fluence rate in the range from 10 to 140 μmol m<sup>-2</sup> s<sup>-1</sup> under white light and to the experimental temperature in the range 15°C-35°C. An \"accommodation\" to light supply is evidenced by a modulation of the reactivity in relation to the schedule of light application under low fluence rates and the introduction of short darkness intervals during the first 30-s light pulse. The blue light-induced photostimulation is under phytochrome control.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemometric modeling of spectroscopic data for characterizing the visible-light-driven photocatalytic N-dealkylation of rhodamine B on a TiO2 film. 建立光谱数据的化学计量模型,以描述可见光驱动的二氧化钛薄膜上罗丹明 B 的光催化 N-脱烷基反应。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-11-21 DOI: 10.1111/php.14043
Jesús M N Morales, Mirta R Alcaraz, Alba Loto, Eduardo A Parellada, Fiorella Tulli, Faustino E Morán Vieyra, Claudio D Borsarelli
{"title":"Chemometric modeling of spectroscopic data for characterizing the visible-light-driven photocatalytic N-dealkylation of rhodamine B on a TiO<sub>2</sub> film.","authors":"Jesús M N Morales, Mirta R Alcaraz, Alba Loto, Eduardo A Parellada, Fiorella Tulli, Faustino E Morán Vieyra, Claudio D Borsarelli","doi":"10.1111/php.14043","DOIUrl":"https://doi.org/10.1111/php.14043","url":null,"abstract":"<p><p>The green-light driven photocatalytic N-deethylation reaction of Rhodamine B (RhB) on a TiO<sub>2</sub> film was investigated by UV-vis absorption and fluorescence emission spectroscopies, in addition to HPLC and HR-MS, to ascertain the nature of the reaction products. The evolution of the photocatalytic reaction was chemometrically analyzed using Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) of the spectroscopic data to obtain the kinetic and spectral decomposition of the RhB derivatives involved in the reaction. This was then compared with the results obtained by standard HPLC analysis. The MCR-ALS analysis yielded satisfactory spectral and kinetic profiles for RhB and the fully deethylated product, Rhodamine 110. However, the spectral profiles for the N-triethyl (3EtRh) and the mixture of the two isomeric N-diethyl (2EtRh) derivatives exhibited some spectral distortions due to significant spectral overlap between these compounds. In contrast to the HPLC analysis, the MCR-ALS could not resolve the N-ethylrhodamine (EtRh) derivative. The deethylation reactions occurred via independent zero-order steps at the surface of TiO<sub>2</sub>, indicating that the RhB degradation reaction is governed by the adsorption-desorption equilibrium of the dye and derivatives on the photocatalyst surface, thereby enhancing the diffusion of compounds on the surface.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bright and long-lasting aqueous peroxyoxalate chemiluminescence in cellulose microspheres. 纤维素微球中明亮持久的过氧化物水溶液化学发光。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-11-19 DOI: 10.1111/php.14040
Maidileyvis C Cabello, Erick L Bastos, Omar A A El Seoud, Wilhelm J Baader
{"title":"Bright and long-lasting aqueous peroxyoxalate chemiluminescence in cellulose microspheres.","authors":"Maidileyvis C Cabello, Erick L Bastos, Omar A A El Seoud, Wilhelm J Baader","doi":"10.1111/php.14040","DOIUrl":"10.1111/php.14040","url":null,"abstract":"<p><p>Water decreases the brightness of the peroxyoxalate chemiluminescence partially due to the hydrolysis of the oxalate reagent. Here, we show that encapsulation of an oxalate ester and the fluorescent activator in microspheres of cellulose esters increases the emission intensity 30 times compared to the same reaction in water without encapsulation, whereas the emission intensity decay rate constants are considerably lower. Emission intensities, rate constants and chemiluminescence quantum yields increase with increasing hydrogen peroxide concentrations. These results expand the potential of application of chemiluminescence, contributing for the development of ultrasensitive analytical methods.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice. 不同剂量的单波长和双波长全身光生物调制对肥胖小鼠代谢参数的影响
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-11-18 DOI: 10.1111/php.14041
Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes
{"title":"The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.","authors":"Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes","doi":"10.1111/php.14041","DOIUrl":"https://doi.org/10.1111/php.14041","url":null,"abstract":"<p><p>Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm<sup>2</sup>) composed of 20 LED clusters, 2.14 mW/cm<sup>2</sup>/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm<sup>2</sup>) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of chatbots in queries concerning fundamental concepts in photochemistry. 聊天机器人在光化学基本概念查询中的表现。
IF 2.6 4区 生物学
Photochemistry and Photobiology Pub Date : 2024-11-04 DOI: 10.1111/php.14037
Masahiko Taniguchi, Jonathan S Lindsey
{"title":"Performance of chatbots in queries concerning fundamental concepts in photochemistry.","authors":"Masahiko Taniguchi, Jonathan S Lindsey","doi":"10.1111/php.14037","DOIUrl":"https://doi.org/10.1111/php.14037","url":null,"abstract":"<p><p>The advent of chatbots raises the possibility of a paradigm shift across society including the most technical of fields with regard to access to information, generation of knowledge, and dissemination of education and training. Photochemistry is a scientific endeavor with roots in chemistry and physics and branches that encompass diverse disciplines ranging from astronomy to zoology. Here, five chatbots have each been challenged with 13 photochemically relevant queries. The chatbots included ChatGPT 3.5, ChatGPT 4.0, Copilot, Gemini Advanced, and Meta AI. The queries encompassed fundamental concepts (e.g., \"Why is the fluorescence spectrum typically the mirror image of the absorption spectrum?\"), practical matters (e.g., \"What is the inner filter effect and how to avoid it?\"), philosophical matters (\"Please create the most important photochemistry questions.\"), and specific molecular features (e.g., \"Why are azo dyes non-fluorescent?\"). The chatbots were moderately effective in answering queries concerning fundamental concepts in photochemistry but were glaringly deficient in specialized queries for dyes and fluorophores. In some instances, a correct response was embedded in verbose scientific nonsense whereas in others the entire response, while grammatically correct, was utterly meaningless. The unreliable accuracy makes present chatbots poorly suited for unaided educational purposes and highlights the importance of domain experts.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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