Photochemistry and Photobiology最新文献_第9页

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models. 光动力疗法在头颈癌中的作用：体内模型的综合综述。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-23 DOI: 10.1111/php.70122

Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues

{"title":"The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models.","authors":"Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues","doi":"10.1111/php.70122","DOIUrl":"https://doi.org/10.1111/php.70122","url":null,"abstract":"Photodynamic therapy (PDT) is a minimally invasive treatment that combines a photosensitizer, light, and oxygen to induce localized oxidative stress, resulting in tumor cell death, vascular damage, and immune modulation. This review aimed to summarize the effects of PDT on tumor progression in in vivo models of head and neck cancer. A systematic search was performed across PubMed/MEDLINE, Embase, Scopus, SciELO, and LILACS for studies published between 2015 and 2026, following PRISMA-ScR guidelines and the PICO framework. Eligible studies included animal models with head and neck tumors treated with PDT using non-conjugated photosensitizers. Extracted outcomes included tumor growth, survival rates, histological and molecular changes, immune activation, and adverse effects. Quality assessment was achieved by SYRCLE tools. Preliminary analysis indicates that PDT with different photosensitizers can reduce tumor growth, prolong survival, increase tumor cell death, decrease proliferation and angiogenesis, induce reactive oxygen species production, and modulate immune responses in preclinical models, without apparent toxicity. Despite these promising results, methodological heterogeneity and insufficient dosimetric reporting limit reproducibility. Overall, these findings highlight the therapeutic potential of PDT with different photosensitizers in head and neck preclinical studies and underscore the need for standardized protocols to improve reproducibility and support clinical translation.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-treatment in situ photo-vaccination with paclitaxel prodrug-PDT enables durable local and abscopal tumor control in a bilateral Colon 26 model. 在双侧结肠26模型中，紫杉醇前药pdt单次原位光免疫治疗能够持久地控制局部和腹腔肿瘤。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-23 DOI: 10.1111/php.70124

Kazi Md Mahabubur Rahman, Sheryl Dsouza, Soniya Kumbham, Prabhanjan Giram, Ganesh Bist, Sukyung Woo, Elizabeth Wohlfert, Roberto Pili, Youngjae You

{"title":"Single-treatment in situ photo-vaccination with paclitaxel prodrug-PDT enables durable local and abscopal tumor control in a bilateral Colon 26 model.","authors":"Kazi Md Mahabubur Rahman, Sheryl Dsouza, Soniya Kumbham, Prabhanjan Giram, Ganesh Bist, Sukyung Woo, Elizabeth Wohlfert, Roberto Pili, Youngjae You","doi":"10.1111/php.70124","DOIUrl":"https://doi.org/10.1111/php.70124","url":null,"abstract":"In situ photo-vaccination (ISPV) is a promising cancer immunomodulation strategy that combines photodynamic therapy (PDT) with targeted release of chemotherapy to transform tumors into personalized vaccines. However, its efficacy in controlling established, larger distal tumors remains limited, reflecting a significant challenge among therapeutic cancer vaccines. To address this, we used a bilateral Colon 26 murine tumor model to systematically optimize ISPV parameters, including drug-light interval, paclitaxel prodrug dose, light dose, size of the illuminated tumor (related to antigen dose), and checkpoint blockade, and to link these to cellular mechanisms of immunogenic cell death. A low prodrug dose (0.5 μmol/kg compared to ~24 μmol/kg of Paclitaxel in mice) and a fluence rate of 75 mW/cm2 for 30 min with a 30-min drug-light interval produced the strongest systemic responses. Abscopal efficacy was strongly linked to antigen dose: treating larger primary tumors expedited control of distant tumors, allowing the suppression of untreated tumors to a size comparable to the primary tumor. Checkpoint inhibition with anti-CTLA-4 was essential, as its removal eliminated distant tumor control. Importantly, optimized ISPV reproducibly controlled distant tumors of a size equivalent to the treated primary, an outcome rarely achieved with other in situ vaccination approaches. These findings establish a mechanistically informed framework for PDT-driven ISPV and provide a strong rationale for translation of this strategy to the treatment of metastatic cancer.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-temperature luminescence and curcumin-sensitized singlet oxygen generation. 低温发光和姜黄素敏化单线态氧生成。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-12 DOI: 10.1111/php.70125

Vitaly Yu Plavskii, Andrei N Sobchuk, Aliaksandr V Mikulich, Olga N Dudinova, Antonina I Tretyakova, Ludmila G Plavskaya, Tatsiana S Ananich, Valentin N Knyukshto

{"title":"Low-temperature luminescence and curcumin-sensitized singlet oxygen generation.","authors":"Vitaly Yu Plavskii, Andrei N Sobchuk, Aliaksandr V Mikulich, Olga N Dudinova, Antonina I Tretyakova, Ludmila G Plavskaya, Tatsiana S Ananich, Valentin N Knyukshto","doi":"10.1111/php.70125","DOIUrl":"https://doi.org/10.1111/php.70125","url":null,"abstract":"Detailed comparative studies of spectral and fluorescent properties of curcumin in solutions at room temperature (293 K) and in rigid glass matrices of 2-methyltetrahydrofuran and ethanol at liquid nitrogen temperature (77 K) were carried out. It was shown that the transition to low temperature, accompanied by a decrease in the efficacy of non-radiative processes, manifests itself (depending on the solvent) in a 3- to 7-fold increase in the fluorescence quantum yield and fluorescence decay time, a sharp decrease in the Stokes shift, and the appearance of a vibrational structure in the fluorescence and fluorescence excitation spectra of curcumin. Rigid glass matrices were used to record phosphorescence, the attribution of which to curcumin was confirmed for the first time by the correspondence of its excitation spectrum to the fluorescence excitation spectrum at 77 K. The phosphorescence maximum of curcumin was shown to be located at <math> <semantics> <mrow><msubsup><mi>λ</mi> <mi>fl</mi> <mi>max</mi></msubsup> </mrow> <annotation>$$ {lambda}_{mathrm{fl}}^{mathrm{max}} $$</annotation></semantics> </math> = 635 nm, which differs significantly from the data ( <math> <semantics> <mrow><msubsup><mi>λ</mi> <mi>fl</mi> <mi>max</mi></msubsup> </mrow> <annotation>$$ {lambda}_{mathrm{fl}}^{mathrm{max}} $$</annotation></semantics> </math> = 730 nm) of the most cited work on curcumin photonics. The quantum yield of curcumin phosphorescence and its decay times were estimated for each solvent. By monitoring the luminescence of curcumin-sensitized singlet oxygen generation in the 1270 nm region, its quantum yield (φΔ) was determined in a number of organic solvents. The obtained values φΔ are 1.4-2.0 times higher than the literature data from 30 years ago.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial photodynamic therapy in Candida spp. biofilms: In vitro and in vivo protocols. 念珠菌生物膜的抗菌光动力治疗：体外和体内方案。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-10 DOI: 10.1111/php.70116

Lívia Mara Alves Figueiredo-Godoi, Ana Júlia Barbosa Tomé, Cristina Kurachi

引用次数: 0

Unraveling the mechanism of high-efficiency CO₂ fixation in the high CO₂ tolerant Oedocladium carolinianum: Synergistic enhancement of photosynthetic light conversion and carbon assimilation. 高CO2耐受性卡罗来纳酸盐高效CO2固定机制的揭示：光合光转化和碳同化的协同增强。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-10 DOI: 10.1111/php.70113

Danni Cui, Ruoqi Han, Litao Zhang, Wenjie Yu, Jianguo Liu

{"title":"Unraveling the mechanism of high-efficiency CO2 fixation in the high CO2 tolerant Oedocladium carolinianum: Synergistic enhancement of photosynthetic light conversion and carbon assimilation.","authors":"Danni Cui, Ruoqi Han, Litao Zhang, Wenjie Yu, Jianguo Liu","doi":"10.1111/php.70113","DOIUrl":"https://doi.org/10.1111/php.70113","url":null,"abstract":"The filamentous microalga Oedocladium carolinianum, capable of synthesizing high-value compounds like astaxanthin, represents a promising candidate for integrated carbon capture and biorefinery. This study investigated its physiological and molecular responses to a wide range of CO2 concentrations (0.04%-20%) at an aeration rate of 500 mL min-1, without CO2 addition during the night, to assess carbon fixation efficiency and application potential. Results demonstrated that O. carolinianum possesses remarkable tolerance to high CO2 levels. The optimal 5% CO2 treatment yielded the highest average carbon fixation rate of 243.51 mg L-1 d-1. Physiologically, CO2 enrichment markedly enhanced photosynthetic performance: it boosted the efficiency of Photosystem II, accelerated electron transport rates, and concurrently reduced respiratory energy loss. Furthermore, CO2 aeration stabilized the culture pH within a neutral range by counteracting photosynthetic alkalinization, thereby promoting algal growth. Transcriptomic analysis revealed that optimal CO2 concentrations (5%-10%) systematically upregulated genes encoding key components of the photosynthetic apparatus-including antenna proteins, both photosystems, and the Calvin cycle enzymes-thereby orchestrating a coordinated enhancement of carbon assimilation metabolism. This study elucidates the integrated physiological and molecular basis of efficient carbon fixation in O. carolinianum under elevated CO2, supporting its potential application in industrial flue gas remediation and sustainable natural astaxanthin coproduction.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of spectrum, irradiance, and duration of exposure on light-induced melatonin suppression in healthy adults. 光谱、辐照度和暴露时间对健康成人光诱导褪黑激素抑制的影响。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-05 DOI: 10.1111/php.70115

Helmut Piazena, Leonora Franke, Ralf Uebelhack, Thomas Penzel, Ingo Fietze

{"title":"The effects of spectrum, irradiance, and duration of exposure on light-induced melatonin suppression in healthy adults.","authors":"Helmut Piazena, Leonora Franke, Ralf Uebelhack, Thomas Penzel, Ingo Fietze","doi":"10.1111/php.70115","DOIUrl":"https://doi.org/10.1111/php.70115","url":null,"abstract":"The aim of the study was to test the applicability of the action spectrum of melatonin suppression (MS) based on monochromatic experimental data from Brainard et al. (Journal of Neuroscience, 2001, 21, 6405) and Thapan et al. (Journal of Physiology, 2001, 535, 261) to quantify MS using white light and to characterize its temporal course during the first hour of exposure. Using a within-subject design, 32 healthy adults (12 males/20 females) with free pupil adaptation were exposed to white light of 1904-6996 K in correlated color temperature (CCT), and to blue light (BL, 474 nm). Two \"circadian effective\" irradiances (Ec = 0.264 W m-2 and 0.528 W m-2) based on Gall's metric (Licht, 2002, 54, 1292) were applied for 60 min using ganzfeld devices. Melatonin concentrations were measured in blood plasma. For 25 participants with complete data sets at Ec = 0.264 W m-2, the r-ANOVA indicated a significant difference in MS between the five different light spectra, F(4,96) = 4.97, p = 0.011. The Bonferroni-corrected post hoc paired t-test (α = 0.005) showed significantly lower melatonin reduction by BL than white light of 2883 K and 1904 K, but not vs. 6997 K and 4663 K. This was due to an unexpectedly high proportion of 11 subjects (=44%) who did not respond to BL with MS (\"BL non-responders\"). For 14 subjects (\"BL responders\", =56%), r-ANOVA confirmed equivalent values of MS under all five lighting conditions at both irradiances. Additivity of spectral contributions to the circadian effectiveness of white light is limited, as is reciprocity only with respect to cold white light.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of far-UVC irradiation on the presence and concentration of ESKAPEE pathogens on hospital surfaces: Study protocol for a multi-site, double-blinded randomized controlled trial in La Paz, Bolivia. 远紫外线照射对医院表面ESKAPEE病原体存在和浓度的影响：玻利维亚拉巴斯一项多地点、双盲随机对照试验的研究方案。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-04 DOI: 10.1111/php.70110

Lindsay B Saber, Melani Rojas, Darcy M Anderson, Deverick J Anderson, Holger Claus, Ryan Cronk, Karl G Linden, Megan E J Lott, Lewis J Radonovich, Bobby G Warren, Richard D Williamson, Richard L Vincent, Sergio Gutiérrez-Cortez, Carla Calderón Toledo, Joe Brown

{"title":"The effects of far-UVC irradiation on the presence and concentration of ESKAPEE pathogens on hospital surfaces: Study protocol for a multi-site, double-blinded randomized controlled trial in La Paz, Bolivia.","authors":"Lindsay B Saber, Melani Rojas, Darcy M Anderson, Deverick J Anderson, Holger Claus, Ryan Cronk, Karl G Linden, Megan E J Lott, Lewis J Radonovich, Bobby G Warren, Richard D Williamson, Richard L Vincent, Sergio Gutiérrez-Cortez, Carla Calderón Toledo, Joe Brown","doi":"10.1111/php.70110","DOIUrl":"https://doi.org/10.1111/php.70110","url":null,"abstract":"Healthcare-associated infections (HAIs) are a known and growing problem worldwide, including those caused by ESKAPEE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., and Escherichia coli. Far-UVC is a novel disinfection method that inactivates pathogenic microbes in air and on surfaces, but is safe for use in occupied spaces. We will implement a multi-site, double-blinded, clustered randomized controlled trial (cRCT) in two hospitals with a high burden of ESKAPEE pathogens. Intervention spaces will receive functioning far-UVC lamps and control arm spaces will receive visually identical lamps that do not emit UV light (shams), randomly allocated to 10 sites per arm per hospital. We will collect environmental samples (air and surface swabs) and measure ESKAPEE pathogens via culture and sequencing in longitudinal monitoring. We hypothesize that the prevalence of ESKAPEE pathogens on intervention site surfaces will be reduced, compared with control arm surfaces.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous compounds of mammalian (boar) sperm sensitizing the formation of reactive oxygen species. 哺乳动物（野猪）精子的内源性化合物对活性氧的形成敏感。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-04 DOI: 10.1111/php.70121

Vitaly Yu Plavskii, Antonina I Tretyakova, Aliaksandr V Mikulich, Andrei N Sobchuk, Tatsiana S Ananich, Ludmila G Plavskaya, Sergey V Yakimchuk, Ihar A Leusenka, Olga N Dudinova, Aliaksei L Shmitsko, Alexander I Budevich

{"title":"Endogenous compounds of mammalian (boar) sperm sensitizing the formation of reactive oxygen species.","authors":"Vitaly Yu Plavskii, Antonina I Tretyakova, Aliaksandr V Mikulich, Andrei N Sobchuk, Tatsiana S Ananich, Ludmila G Plavskaya, Sergey V Yakimchuk, Ihar A Leusenka, Olga N Dudinova, Aliaksei L Shmitsko, Alexander I Budevich","doi":"10.1111/php.70121","DOIUrl":"https://doi.org/10.1111/php.70121","url":null,"abstract":"Interest in identifying the type of endogenous compounds capable of initiating the formation of reactive oxygen species (ROS) in boar semen upon photoexcitation is driven by the use of photobiomodulation methods in artificial insemination of pigs and the unclear mechanisms underlying the stimulating effect of light on sperm function. One hypothesis regarding the mechanism of biological activity of light suggests the crucial role of ROS in mediating the effects of photobiomodulation. This study examined endogenous fluorophores in boar semen characterized by absorption in the UV-A and visible spectral regions and capable of generating ROS upon photoexcitation. For the first time, weak fluorescence of endogenous porphyrin sensitizers was detected in freshly collected boar ejaculate (native sperm) alongside intense fluorescence of NADH (NAD(P)H) coenzymes and flavins (flavin mononucleotide, FMN, and flavin adenine dinucleotide, FAD). Using steady-state and kinetic spectrofluorimetry, the types of porphyrins localized in the sperm were identified, and the presence of uroporphyrin III, coproporphyrin III, and their zinc complexes was established. Using a chemiluminescent assay for monitoring ROS levels and specific ROS quenchers (scavengers), it was shown that exposure of boar sperm to radiation of blue spectral region leads to the formation of singlet oxygen and hydrogen peroxide. It was concluded that light-induced generation of ROS (primarily singlet oxygen) by endogenous porphyrins and flavins can alter the redox state of sperm and, at low ROS concentrations, exert a mild regulatory effect on their functional activity.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cis-urocanic acid formation following far-UVC exposure and associated signaling responses in keratinocytes. 远紫外线暴露后顺式尿尿酸的形成及其在角化细胞中的相关信号反应。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-03 DOI: 10.1111/php.70118

Lizzie Thomas, Gareth Hazell, Katarzyna Baczynska, Jinkang Zhang, Paul O'Mahoney

{"title":"Cis-urocanic acid formation following far-UVC exposure and associated signaling responses in keratinocytes.","authors":"Lizzie Thomas, Gareth Hazell, Katarzyna Baczynska, Jinkang Zhang, Paul O'Mahoney","doi":"10.1111/php.70118","DOIUrl":"https://doi.org/10.1111/php.70118","url":null,"abstract":"Far-UVC (200-235 nm) has emerged as a safe and effective modality to inactivate pathogens in an indoor setting. trans-urocanic acid (UCA) is a chromophore that resides in the stratum corneum of the skin and is converted into the more biologically active cis isomer upon ultraviolet radiation (UVR) exposure where it initiates immunosuppression. The immunomodulatory potential of far-UVC exposure within the skin is currently unknown, particularly the conversion of trans- to cis-UCA and the resulting downstream signaling. Here, we confirm that far-UVC at 222 nm photoisomerizes trans-UCA into its cis isomer with levels comparable with solar simulated radiation (SSR). Further, we examined changes in cytokine secretion released from the supernatant and mRNA expression of IL-6 and IL-8 as well as key signaling mediators following far-UVC and SSR irradiation in primary human keratinocytes with or without irradiated UCA. Far-UVC alone induced modest non-significant trends in IL-6 and IL-8 secretion, ROS, and C-Jun phosphorylation. In the presence of irradiated UCA, higher mean levels of these mediators and increased STAT3 phosphorylation were observed 24 h post-exposure alongside elevated IL-6 and IL-8 expression. SSR-exposed keratinocytes also increased cytokine secretion; however, responses in the presence of irradiated UCA were associated with lower mean inflammatory signaling and increased p53 phosphorylation, accompanied by non-significant changes in NF-κB activity. Our findings demonstrate that far-UVC can induce trans-cis-UCA photoisomerization and highlight potential interactions between UCA and UVR-induced signaling pathways in keratinocytes. While biological variation in samples perhaps masks significant differences, these observations and trends can inform future work and contribute to a better understanding of chromophore-mediated photochemical processes that may influence cellular responses to far-UVC exposure.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of chalcones structure-related to avobenzone: Photoprotection, photostability, and safety evaluation. 与阿伏苯宗相关的查尔酮结构的发展：光保护、光稳定性和安全性评价。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-05-29 DOI: 10.1111/php.70119

Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli

{"title":"Development of chalcones structure-related to avobenzone: Photoprotection, photostability, and safety evaluation.","authors":"Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli","doi":"10.1111/php.70119","DOIUrl":"https://doi.org/10.1111/php.70119","url":null,"abstract":"Chalcones are α,β-unsaturated ketones with extended π-conjugation, making them promising scaffolds for the development of organic UV filters. In this study, a series of substituted chalcones inspired by the chemical structure of avobenzone (AVO) was synthesized and systematically evaluated for UV absorption profiles, photostability, antioxidant potential, photoprotection, and safety-related properties. Among the compounds, the 2-hydroxychalcones 3ca and 3cb showed the most promising profiles. Chalcone 3ca exhibited λmax at 365 nm, critical wavelength of 386 nm, UVA/UVB ratio of 6.3, and molar absorptivity of 58,880 M-1 cm-1, whereas 3cb showed λmax at 353 nm, critical wavelength of 376 nm, UVA/UVB ratio of 3.2, and molar absorptivity of 28,900 M-1 cm-1. Both compounds fulfilled broad-spectrum protection criteria and showed <5% degradation after UVA and UVB irradiation, with photostability comparable to benzophenone-3 and superior to AVO. Formulations containing 3ca and 3cb reduced UVA-induced DNA damage by 90.4% and 95.1%, respectively. Skin permeation studies demonstrated predominant retention in the stratum corneum (94.1% for 3ca and 97.4% for 3cb), minimal penetration into viable epidermis and dermis, and no detectable compound in receptor fluid. Both chalcones showed no relevant irritation in the HET-CAM assay and no significant alterations in skin biometric parameters after topical application. Collectively, these findings support the potential of hydroxy-substituted chalcones as photostable broad-spectrum UV filters for topical application.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148056207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0