Photochemistry and Photobiology最新文献_第8页

Full-spectrum cannabidiol reduces UVB damage through the inhibition of TGF-β1 and the NLRP3 inflammasome. 全谱大麻二酚通过抑制 TGF-β1 和 NLRP3 炎性体减少 UVB 损伤。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-07-03 DOI: 10.1111/php.13993

I M Urrutia-Ortega, I Valencia, O Ispanixtlahuatl-Meraz, J C Benítez-Flores, A M Espinosa-González, E A Estrella-Parra, C M Flores-Ortiz, Y I Chirino, J G Avila-Acevedo

{"title":"Full-spectrum cannabidiol reduces UVB damage through the inhibition of TGF-β1 and the NLRP3 inflammasome.","authors":"I M Urrutia-Ortega, I Valencia, O Ispanixtlahuatl-Meraz, J C Benítez-Flores, A M Espinosa-González, E A Estrella-Parra, C M Flores-Ortiz, Y I Chirino, J G Avila-Acevedo","doi":"10.1111/php.13993","DOIUrl":"10.1111/php.13993","url":null,"abstract":"The thermodynamic characteristics, antioxidant potential, and photoprotective benefits of full-spectrum cannabidiol (FS-CBD) against UVB-induced cellular death were examined in this study. In silico analysis of CBD showed antioxidant capacity via proton donation and UV absorption at 209.09, 254.73, and 276.95 nm, according to the HAT and SPLET methodologies. FS-CBD protected against UVB-induced bacterial death for 30 min. FS-CBD protected against UVB-induced cell death by 42% (1.5 μg/mL) and 35% (3.5 μg/mL) in an in vitro keratinocyte cell model. An in vivo acute irradiated CD-1et/et mouse model (UVB-irradiated for 5 min) presented very low photoprotection when FS-CBD was applied cutaneously, as determined by histological analyses. In vivo skin samples showed that FS-CBD regulated inflammatory responses by inhibiting the inflammatory markers TGF-β1 and NLRP3. The docking analysis showed that the CBD molecule had a high affinity for TGF-β1 and NLRP3, indicating that protection against inflammation might be mediated by blocking these proinflammatory molecules. This result was corroborated by the docking interactions between CBD and TGF-β1 and NLRP3, which resulted in a high affinity and inhibition of both proteins The present work suggested a FS-CBD moderate photoprotective agent against UVB light-induced skin damage and that this effect is partially mediated by its anti-inflammatory activity.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"83-105"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How long does the biological effect of a red light-emitting diode last on adipose-derived mesenchymal stem cells? 红色发光二极管对脂肪间充质干细胞的生物效应能持续多久？

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-06-18 DOI: 10.1111/php.13983

Vitor Pocani da Rocha, Barbara Sampaio Dias Martins Mansano, Carolina Fernanda Chaves Dos Santos, Ighor Luiz Azevedo Teixeira, Helenita Antonia de Oliveira, Stella Sousa Vieira, Ednei Luiz Antonio, Maria Cristina de Oliveira Izar, Francisco Antonio Helfenstein Fonseca, Andrey Jorge Serra

{"title":"How long does the biological effect of a red light-emitting diode last on adipose-derived mesenchymal stem cells?","authors":"Vitor Pocani da Rocha, Barbara Sampaio Dias Martins Mansano, Carolina Fernanda Chaves Dos Santos, Ighor Luiz Azevedo Teixeira, Helenita Antonia de Oliveira, Stella Sousa Vieira, Ednei Luiz Antonio, Maria Cristina de Oliveira Izar, Francisco Antonio Helfenstein Fonseca, Andrey Jorge Serra","doi":"10.1111/php.13983","DOIUrl":"10.1111/php.13983","url":null,"abstract":"This research investigated the duration of the influence of red light-emitting diodes (LED, 630 nm; output power: 2452.5 mW; laser beam: 163.5 cm2; irradiance: 15 mW/cm2; radiant exposure: 4 J/cm2) on different periods after irradiation (6, 12, 24, 48, and 72 h) on adipose-derived mesenchymal stem cells' (AdMSCs) metabolism and paracrine factors. AdMSCs were irradiated three times every 48 h. Twenty-four hours after the last irradiation, there was a higher MTT absorbance, followed by a decrease after 48 h. The cells' secretome showed increased levels of IL-6 and VEGF after 12 and 24 h, but this was reversed after 48 h. Additionally, LED irradiation resulted in higher levels of nitrite and did not affect oxidative stress markers. LED irradiation had significant effects on AdMSCs after 24 h compared to other groups and its control group.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"206-214"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mitigating effect of street trees, urban flora, and the suburban environment on seasonal peak UV indices: A case study from Brisbane, Australia. 行道树、城市植物群和郊区环境对季节性紫外线峰值指数的缓解作用：澳大利亚布里斯班案例研究。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-06-26 DOI: 10.1111/php.13988

Nathan James Downs, Abdurazaq Amar, John Dearnaley, Harry Butler, Stijn Dekeyser, Damien Igoe, Alfio V Parisi, Nawin Raj, Ravinesh Deo, Joanna Turner

{"title":"The mitigating effect of street trees, urban flora, and the suburban environment on seasonal peak UV indices: A case study from Brisbane, Australia.","authors":"Nathan James Downs, Abdurazaq Amar, John Dearnaley, Harry Butler, Stijn Dekeyser, Damien Igoe, Alfio V Parisi, Nawin Raj, Ravinesh Deo, Joanna Turner","doi":"10.1111/php.13988","DOIUrl":"10.1111/php.13988","url":null,"abstract":"Tree shade, particularly shade that obscures direct sunlight near peak periods of midday solar exposure can have a pronounced effect on potentially harmful ultraviolet radiation, and in turn, strongly influence the maximum daily UV index (UVI). In this study, the seasonal influence of tree shade on the UVI is evaluated from 210 hemispherical sky view images collected alongside public walkways and footpaths from 10 residential Brisbane suburbs. The effective sidewalk UV index is calculated underneath planted tree canopies, adjacent residential gardens, buildings and background tree species. Results are presented with respect to seasonal variations in the diurnal solar elevation for each month of the year at Brisbane's latitude. The research also examines the total reduction in UVI due to the presence of individual tree species, showing reductions in the midday UVI of up to 91% of an equivalent unimpeded sky hemisphere when overhead tree canopies are present. Important footpath tree species for peak midday UVI mitigation include Pongamia pinnata, Xanthostemon chrysanthus, Senna siamea, and Libidibia ferrea. The planting and maintenance of existing tree species already growing alongside residential Brisbane streets will improve the shade characteristics of suburbs and enhance UV protection for local residents.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"251-266"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype. 红光激活难治性胶质母细胞瘤干细胞的耗竭和获得性耐药间质表型的化疗增敏。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-06-23 DOI: 10.1111/php.13985

Bryan Q Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Joseph W R Swain, Zhiming Mai, Hiroaki Wakimoto, Tayyaba Hasan

{"title":"Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype.","authors":"Bryan Q Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Joseph W R Swain, Zhiming Mai, Hiroaki Wakimoto, Tayyaba Hasan","doi":"10.1111/php.13985","DOIUrl":"10.1111/php.13985","url":null,"abstract":"Glioblastoma stem cells (GSCs) are potent tumor initiators resistant to radiochemotherapy, and this subpopulation is hypothesized to re-populate the tumor milieu due to selection following conventional therapies. Here, we show that 5-aminolevulinic acid (ALA) treatment-a pro-fluorophore used for fluorescence-guided cancer surgery-leads to elevated levels of fluorophore conversion in patient-derived GSC cultures, and subsequent red light-activation induces apoptosis in both intrinsically temozolomide chemotherapy-sensitive and -resistant GSC phenotypes. Red light irradiation of ALA-treated cultures also exhibits the ability to target mesenchymal GSCs (Mes-GSCs) with induced temozolomide resistance. Furthermore, sub-lethal light doses restore Mes-GSC sensitivity to temozolomide, abrogating GSC-acquired chemoresistance. These results suggest that ALA is not only useful for fluorescence-guided glioblastoma tumor resection, but that it also facilitates a GSC drug-resistance agnostic, red light-activated modality to mop up the surgical margins and prime subsequent chemotherapy.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"215-229"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does photobiomodulation alter mitochondrial dynamics? 光生物调制会改变线粒体动力学吗？

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-05-22 DOI: 10.1111/php.13963

Larissa Alexsandra da Silva Neto Trajano, Priscyanne Barreto Siqueira, Mariana Moreno de Sousa Rodrigues, Bruno Ricardo Barreto Pires, Adenilson de Souza da Fonseca, Andre Luiz Mencalha

{"title":"Does photobiomodulation alter mitochondrial dynamics?","authors":"Larissa Alexsandra da Silva Neto Trajano, Priscyanne Barreto Siqueira, Mariana Moreno de Sousa Rodrigues, Bruno Ricardo Barreto Pires, Adenilson de Souza da Fonseca, Andre Luiz Mencalha","doi":"10.1111/php.13963","DOIUrl":"10.1111/php.13963","url":null,"abstract":"Mitochondrial dysfunction is one of the leading causes of disease development. Dysfunctional mitochondria limit energy production, increase reactive oxygen species generation, and trigger apoptotic signals. Photobiomodulation is a noninvasive, nonthermal technique involving the application of monochromatic light with low energy density, inducing non-thermal photochemical effects at the cellular level, and it has been used due to its therapeutic potential. This review focuses on the mitochondrial dynamic's role in various diseases, evaluating the possible therapeutic role of low-power lasers (LPL) and light-emitting diodes (LED). Studies increasingly support that mitochondrial dysfunction is correlated with severe neurodegenerative diseases such as Parkinson's, Huntington's, Alzheimer's, and Charcot-Marie-Tooth diseases. Furthermore, a disturbance in mitofusin activity is also associated with metabolic disorders, including obesity and type 2 diabetes. The effects of PBM on mitochondrial dynamics have been observed in cells using a human fibroblast cell line and in vivo models of brain injury, diabetes, spinal cord injury, Alzheimer's disease, and skin injury. Thus, new therapies aiming to improve mitochondrial dynamics are clinically relevant. Several studies have demonstrated that LPL and LED can be important therapies to improve health conditions when there is dysfunction in mitochondrial dynamics.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"21-37"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiomodulation of Na,K-ATPase in native membrane fraction and reconstituted in DPPC:DPPE-liposome. 原生膜部分和在 DPPC:DPPE 脂质体中重组的 Na,K-ATP 酶的光生物调节。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-06-24 DOI: 10.1111/php.13987

Gustavo Scanavachi, Juliana S Yoneda, Heitor G Sebinelli, Leandro R S Barbosa, Pietro Ciancaglini, Rosangela Itri

{"title":"Photobiomodulation of Na,K-ATPase in native membrane fraction and reconstituted in DPPC:DPPE-liposome.","authors":"Gustavo Scanavachi, Juliana S Yoneda, Heitor G Sebinelli, Leandro R S Barbosa, Pietro Ciancaglini, Rosangela Itri","doi":"10.1111/php.13987","DOIUrl":"10.1111/php.13987","url":null,"abstract":"Studies focusing on how photobiomodulation (PBM) can affect the structure and function of proteins are scarce in the literature. Few previous studies have shown that the enzymatic activity of Na,K-ATPAse (NKA) can be photo-modulated. However, the variability of sample preparation and light irradiation wavelengths have not allowed for an unequivocal conclusion about the PBM of NKA. Here, we investigate minimal membrane models containing NKA, namely, native membrane fraction and DPPC:DPPE proteoliposome upon laser irradiation at wavelengths 532, 650, and 780 nm. Interestingly, we show that the PBM on the NKA enzymatic activity has a bell-shaped profile with a stimulation peak (~15% increase) at around 20 J.cm-2 and 6 J.cm-2 for the membrane-bound and the proteoliposome samples, respectively, and are practically wavelength independent. Further, by normalizing the enzymatic activity by the NKA enzyme concentration, we show that the PBM response is related to the protein amount with small influence due to protein's environment. The stimulation decays over time reaching the basal level around 6 h after the irradiation for the three lasers and both NKA samples. Our results demonstrate the potential of using low-level laser therapy to modulate NKA activity, which may have therapeutic implications and benefits.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"230-238"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methods for assessing and removing non-specific photoimmunotherapy damage in patient-derived tumor cell culture models. 评估和消除源自患者的肿瘤细胞培养模型中的非特异性光免疫疗法损伤的方法。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-05-10 DOI: 10.1111/php.13957

Sudip Timilsina, Mohammad Ahsan Saad, Ryan T Lang, Tayyaba Hasan, Bryan Q Spring

{"title":"Methods for assessing and removing non-specific photoimmunotherapy damage in patient-derived tumor cell culture models.","authors":"Sudip Timilsina, Mohammad Ahsan Saad, Ryan T Lang, Tayyaba Hasan, Bryan Q Spring","doi":"10.1111/php.13957","DOIUrl":"10.1111/php.13957","url":null,"abstract":"Tumor-targeted, activatable photoimmunotherapy (taPIT) has been shown to selectively destroy tumor in a metastatic mouse model. However, the photoimmunoconjugate (PIC) used for taPIT includes a small fraction of non-covalently associated (free) benzoporphyrin derivative (BPD), which leads to non-specific killing in vitro. Here, we report a new treatment protocol for patient-derived primary tumor cell cultures ultrasensitive to BPD photodynamic therapy (BPD-PDT). Based on free BPD efflux dynamics, the updated in vitro taPIT protocol precludes non-specific BPD-PDT by silencing the effect of free BPD. Following incubation with PIC, incubating cells with PIC-free medium allows time for expulsion of free BPD whereas BPD covalently bound to PIC fragments is retained. Administration of the light dose after the intracellular free BPD drops below the threshold for inducing cell death helps to mitigate non-specific damage. In this study, we tested two primary ovarian tumor cell lines that are intrinsically chemoresistant, yet ultrasensitive to BPD-PDT such that small amounts of free BPD (a few percent of the total BPD dose) lead to potent induction of cell death upon irradiation. The modifications in the protocol suggested here improve in vitro taPIT experiments that lack in vivo mechanisms of free BPD clearance (i.e., lymph and blood flow).","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"4-20"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of photobiomodulation therapy on pain perception reduction associated with dental anesthetic infiltration injection: A systematic review and meta-analysis. 光生物调节疗法对减轻牙科麻醉剂浸润注射相关痛觉的疗效：系统回顾与荟萃分析。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-06-06 DOI: 10.1111/php.13977

Neda Hakimiha, Pantea Amiri, Fatemeh Sheibani, Zahra Razzaghi

{"title":"Efficacy of photobiomodulation therapy on pain perception reduction associated with dental anesthetic infiltration injection: A systematic review and meta-analysis.","authors":"Neda Hakimiha, Pantea Amiri, Fatemeh Sheibani, Zahra Razzaghi","doi":"10.1111/php.13977","DOIUrl":"10.1111/php.13977","url":null,"abstract":"Dental anesthetic injections, a common source of patient discomfort, often deter individuals from seeking dental care. Recently, there has been a growing focus on photobiomodulation therapy (PBMT) and its potential role in pain reduction. This systematic review explored the efficacy of PBMT in alleviating pain associated with dental anesthetic infiltration injections. A systematic literature search of different databases was performed up to December, 2023 using specific search strategy to find eligible studies that assessed the impact of PBMT on pain during local anesthesia injections. Data extraction was done based on the inclusion/exclusion criteria. A total of 13 studies, involving 972 patients were included. The studies employed various PBMT parameters, including wavelengths, and energy densities. Meta-analyses revealed a significant reduction in pain with PBMT compared to controls (MD = -0.90, 95% CI: -1.36 to -0.44, and p = 0.0001), with notable heterogeneity (I2 = 91.79%). Stratified analyses by age demonstrated consistent pain reduction in both adults (MD = -0.59, 95% CI: -1.11 to -0.08, and p < 0.0001) and children (MD = -0.59, 95% CI: -1.11 to -0.08, and p = 0.025). In conclusion, it seems that PBMT using infrared diode lasers can effectively reduce injection pain in both pediatric and adult populations. Further research should focus on optimizing PBMT parameters for enhanced pain management during dental procedures.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"53-62"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photochemistry of N-aryl and N-alkyl dibenzothiophene sulfoximines. N- 芳基和 N- 烷基二苯并噻吩亚磺酰亚胺的光化学。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-01-01 Epub Date: 2024-06-24 DOI: 10.1111/php.13978

John C Throgmorton, Alexis J Iverson, Ryan D McCulla

{"title":"Photochemistry of N-aryl and N-alkyl dibenzothiophene sulfoximines.","authors":"John C Throgmorton, Alexis J Iverson, Ryan D McCulla","doi":"10.1111/php.13978","DOIUrl":"10.1111/php.13978","url":null,"abstract":"N-phenyl dibenzothiophene sulfoximine has been demonstrated to produce phenyl nitrene and dibenzothiophene S-oxide upon irradiation with UV-A light, and dibenzothiophene S-oxide upon further irradiation releases triplet atomic oxygen. Thus, N-phenyl dibenzothiophene sulfoximine exhibits a rare dual-release capability in its photochemistry. In this work, N-substituted dibenzothiophene sulfoximine derivatives are irradiated with UV-A light to compare their photochemistry and quantum yield of dibenzothiophene S-oxide production with that of N-phenyl dibenzothiophene sulfoximine. Both N-aryl and N-alkyl derivatives of dibenzothiophene sulfoximine are examined to observe their effects on the quantum yield of the photolysis reaction. Adding electron withdrawing N-aryl substituents is shown to increase the quantum yield of dibenzothiophene S-oxide production, while adding electron donating N-aryl substituents is shown to decrease the quantum yield. The quantum yield was slightly lowered or not increased by most N-alkyl substituents. Furthermore, the quantum yield was not augmented by branching and steric hindrance effects associated with the N-alkyl substituents. These results suggest that electronic modulation of the sulfoximine bonds affects the observed photolysis reaction.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"180-187"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy of cancer-associated infections. 癌症相关感染的光动力治疗。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-12-31 DOI: 10.1111/php.14038

Giulia Kassab, Juan Chen, Gang Zheng

引用次数: 0