Photochemistry and Photobiology最新文献_第8页

Editorial (2026, issue 4, July/August). 社论（2026年7月/ 8月第4期）。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2026-07-06 DOI: 10.1111/php.70133

Alexander Greer

引用次数: 0

Role of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on immediate implant placement in type 2 diabetic rats. 抗菌光动力疗法（aPDT）和全身白藜芦醇在2型糖尿病大鼠种植体即刻植入中的作用。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2025-10-24 DOI: 10.1111/php.70046

Letícia Pitol-Palin, Carolina Sayuri Wajima, Fábio Roberto de Souza Batista, Naara Gabriela Monteiro, Isadora Castaldi Sousa, Valdir Gouveia Garcia, Dóris Hissako Matsushita, Letícia Helena Theodoro, Roberta Okamoto

{"title":"Role of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on immediate implant placement in type 2 diabetic rats.","authors":"Letícia Pitol-Palin, Carolina Sayuri Wajima, Fábio Roberto de Souza Batista, Naara Gabriela Monteiro, Isadora Castaldi Sousa, Valdir Gouveia Garcia, Dóris Hissako Matsushita, Letícia Helena Theodoro, Roberta Okamoto","doi":"10.1111/php.70046","DOIUrl":"10.1111/php.70046","url":null,"abstract":"This study investigated the synergistic effects of resveratrol and antimicrobial photodynamic therapy (aPDT) on peri-implant bone repair in a type 2 diabetes model. Forty-eight rats were allocated into four groups: normoglycemic, normoglycemic + resveratrol, type 2 diabetes (T2D), and T2D + resveratrol. Diabetes was induced using a cafeteria diet and streptozotocin (35 mg/kg). Resveratrol (100 mg/kg) was administered systemically beginning 7 days later. After 14 days, maxillary molars were extracted, and surgical drilling was performed. Half of the animals in each group received aPDT (methylene blue and 660 nm diode laser) before immediate implant placement. Animals were euthanized 28 days post-surgery for biomechanical, RT-PCR, and confocal microscopy analyses. Resveratrol improved glycemic control and body weight. In T2D animals, aPDT significantly enhanced implant removal torque. Gene expression analyses revealed downregulation of bone resorption markers and upregulation of bone mineralization genes in T2D and T2D + resveratrol groups treated with aPDT. Confocal microscopy demonstrated increased mineral apposition rates in animals treated with resveratrol and/or aPDT. These findings suggest that the combination of systemic resveratrol and local aPDT enhances peri-implant bone healing under diabetic conditions, highlighting a potential therapeutic approach to improve implant osseointegration in compromised metabolic states.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"934-948"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145368510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring natural sunscreens: UVB protection and antioxidant properties in gadusol-rich fish roes extracts. 探索天然防晒霜：富含gadusol的鱼卵提取物的UVB保护和抗氧化特性。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2025-10-06 DOI: 10.1111/php.70042

Rocío Isla Naveira, Gabriela Hollmann, José María Monserrat, Ana Paula S Votto, Julie Medeiros da Silveira, Andressa Mai Matsumoto, Lais Zortéa, Andy Joel Taipe Huisa, Agueda E Massa, M Sandra Churio

{"title":"Exploring natural sunscreens: UVB protection and antioxidant properties in gadusol-rich fish roes extracts.","authors":"Rocío Isla Naveira, Gabriela Hollmann, José María Monserrat, Ana Paula S Votto, Julie Medeiros da Silveira, Andressa Mai Matsumoto, Lais Zortéa, Andy Joel Taipe Huisa, Agueda E Massa, M Sandra Churio","doi":"10.1111/php.70042","DOIUrl":"10.1111/php.70042","url":null,"abstract":"The search for natural alternatives to synthetic sunscreens has driven interest in marine compounds with antioxidant and UV-protective properties. The present study expands our understanding of the potential of gadusol by evaluating the photochemoprotective and antioxidant effects of extracts from an underexploited marine by-product: the roes of yellowtail amberjack fish (Seriola lalandi). UVB-mediated responses were studied in vitro and in vivo using HaCaT keratinocytes and Caenorhabditis elegans worms, respectively. Additionally, several antioxidant assays were conducted to evaluate the antioxidant capacity and thermal stability over time. We also tested the docking binding of gadusol to the Nrf2-binding domain of Keap1 to better understand its potential chemoprotective role. Overall, the gadusol-containing extracts exhibited remarkable stability over time, offering effective protection against UVB radiation in both in vitro and in vivo models. This information contributes to a better characterization of the functional role of gadusol in crude extracts and its relevance for the design of innovative applications in various pharmaceutical and cosmetic industries.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"877-888"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiomodulation and platelet-rich fibrin in the gastrocnemius muscle submitted to calcaneal tendinopathy in rats. 大鼠跟骨肌腱病变对腓肠肌光生物调节和富血小板纤维蛋白的影响。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2025-09-10 DOI: 10.1111/php.70034

Pâmela Andressa Pauletto, Caroline Hammerschmitt Eduardo Schmitt, Fransael Franklyn Araújo da Silva, Maria Eduarda Luckner, Lucinéia de Fátima Chasko Ribeiro, Márcia Miranda Torrejais, Gladson Ricardo Flor Bertolini

{"title":"Photobiomodulation and platelet-rich fibrin in the gastrocnemius muscle submitted to calcaneal tendinopathy in rats.","authors":"Pâmela Andressa Pauletto, Caroline Hammerschmitt Eduardo Schmitt, Fransael Franklyn Araújo da Silva, Maria Eduarda Luckner, Lucinéia de Fátima Chasko Ribeiro, Márcia Miranda Torrejais, Gladson Ricardo Flor Bertolini","doi":"10.1111/php.70034","DOIUrl":"10.1111/php.70034","url":null,"abstract":"The study investigated the impact of different treatments on recovery from calcaneal tendinopathy in rats, focusing on the gastrocnemius muscle. Tendinopathy is caused by repetitive overload, leading to structural collagen damage and chronic muscle inflammation. Three therapeutic approaches were compared: photobiomodulation (PBM), advanced platelet-rich fibrin (A-PRF) injection, and a combination of the two. Seventy-five rats were separated into five groups: control (CON), injury (LES), PRF (A-PRF), photobiomodulation (PBM) and combined therapy (A-PRF + PBM). Tendinopathy was induced by compression of the calcaneal tendon. The treatment was applied at specific intervals, and the animals were assessed for muscle strength and subjected to histological and morphometric analysis of the muscle. LES showed the lowest muscle strength. The treated groups (PBM, A-PRF and A-PRF + PBM) had an increase in strength between days 7 and 21, but there were no signs of muscle damage or significant recovery in the muscle fibers. The combined therapy group showed greater production of type III collagen in the connective tissue, indicating a more significant repair effect. In contrast, the neuromuscular junctions in the groups treated with PRF were smaller, suggesting possible structural alterations. The combination of therapies showed superior results to treatment alone, promoting greater tissue repair in the gastrocnemius muscle, especially due to the increase in type III collagen.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"985-995"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A thioether-linked iodinated BODIPY-benzimidazole photosensitizer: Efficient light-induced production of singlet oxygen and superoxide radicals and photobiological activity. 硫醚连接碘化bodipy -苯并咪唑光敏剂：单线态氧和超氧自由基的有效光诱导生产和光生物活性。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2025-08-25 DOI: 10.1111/php.70030

Shawn Swavey, Owen Focht, Devyn Harvey, Emily Dillon, Sherri A McFarland, Ge Shi

{"title":"A thioether-linked iodinated BODIPY-benzimidazole photosensitizer: Efficient light-induced production of singlet oxygen and superoxide radicals and photobiological activity.","authors":"Shawn Swavey, Owen Focht, Devyn Harvey, Emily Dillon, Sherri A McFarland, Ge Shi","doi":"10.1111/php.70030","DOIUrl":"10.1111/php.70030","url":null,"abstract":"A new iodinated BODIPY dye incorporating a thioether- has been synthesized and characterized. The benzimidazole unit was introduced at the meso-pentafluorophenyl position of the BODIPY scaffold via high-yield click chemistry. This substitution does not alter the strong absorption and emission properties of the BODIPY chromophore and provides a versatile platform for the attachment of pharmacologically important molecules. Further functionalization of the BODIPY core with iodine at the 3- and 5-positions yields a derivative capable of generating reactive oxygen species when irradiated with low energy light. Experimental evidence confirms the production of both singlet oxygen and superoxide radicals, indicating this complex is capable of operating by both Type I and Type II photosensitization pathways. This dual capacity could be responsible for its effectiveness as a photosensitizer and contribute to its photobiological activity against human melanoma cells.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"976-984"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern: A.H. Nejat, M. Eshghpour, N. Danaeifar, M. Abrishami, F. Vahdatinia, and R. Fekrazad, "Effect of Photobiomodulation on The Incidence Of Alveolar Osteitis And Postoperative Pain Following Mandibular Third Molar Surgery: A Double-Blind Randomized Clinical Trial," Photochemistry and Photobiology, 97 no. 5 (2021): 1129-1135. https://doi.org/10.1111/php.13457. 关注表达：A. h . Nejat， M. Eshghpour， N. Danaeifar， M. Abrishami， F. Vahdatinia， R. Fekrazad，“光生物调节对下颌第三磨牙手术后牙槽骨炎和术后疼痛的影响：一项双盲随机临床试验”，光化学与光生物学，1997年第7期。5(2021): 1129-1135。https://doi.org/10.1111/php.13457。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2026-02-26 DOI: 10.1111/php.70086

引用次数: 0

Collagen-derived hydroxyproline-containing cyclic dipeptides prevent photoaging-related inflammatory response in UVB-irradiated epidermal keratinocytes. 胶原来源的含羟基脯氨酸的环二肽防止uvb照射下表皮角质形成细胞的光老化相关炎症反应。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-07-01 Epub Date: 2025-08-24 DOI: 10.1111/php.70026

Yuki Kumazawa, Kazunori Mizuno, Yuki Taga

{"title":"Collagen-derived hydroxyproline-containing cyclic dipeptides prevent photoaging-related inflammatory response in UVB-irradiated epidermal keratinocytes.","authors":"Yuki Kumazawa, Kazunori Mizuno, Yuki Taga","doi":"10.1111/php.70026","DOIUrl":"10.1111/php.70026","url":null,"abstract":"Reactive oxygen species (ROS) are major contributors to skin photoaging, which is cumulatively caused by sunlight exposure. We previously developed a unique collagen hydrolysate, named H-GDCH, enriched with hydroxyproline (Hyp)-containing cyclic dipeptides, cyclo(X-Hyp), using ginger protease and subsequent heat treatment. Here, we demonstrated the inhibitory effects of cyclo(X-Hyp) and H-GDCH on ultraviolet B (UVB)-induced photoaging-related inflammatory response in normal human epidermal keratinocytes (NHEK). Cyclo(X-Hyp) significantly decreased intracellular ROS generated by UVB irradiation. The ROS scavenging ability of cyclo(X-Hyp) was superior to that of the corresponding linear dipeptides (X-Hyp) and Pro-containing cyclic dipeptides [cyclo(X-Pro)], respectively. Cyclo(X-Hyp) suppressed ROS-induced activation of inflammatory pathways, including nuclear factor-κB and mitogen-activated protein kinases, and the subsequent increase in matrix metalloproteinase (MMP)-2/MMP-9; moreover, it inhibited the reduction of type IV collagen. ROS production and the downstream events simulated by UVB were also prevented by culturing with H-GDCH. Cyclo(X-Hyp) penetrated human dermatomed skin with high efficiency, reaching 10% after a 24-h incubation. These results indicate that cyclo(X-Hyp) and the cyclo(X-Hyp)-rich collagen hydrolysate, H-GDCH, have the potential as anti-photoaging agents in skin health applications, including cosmetics and functional foods.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"854-865"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface alteration of Candida albicans after antifungal photodynamic therapy: A Raman spectroscopic study. 抗真菌光动力治疗后白色念珠菌表面改变：拉曼光谱研究。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-30 DOI: 10.1111/php.70132

Phuriphat Techalapha, Iyadara Ngamwatana, Laksika Boonwittaya, Prapassara Sirikarn, Teerasak Damrongrungruang

{"title":"Surface alteration of Candida albicans after antifungal photodynamic therapy: A Raman spectroscopic study.","authors":"Phuriphat Techalapha, Iyadara Ngamwatana, Laksika Boonwittaya, Prapassara Sirikarn, Teerasak Damrongrungruang","doi":"10.1111/php.70132","DOIUrl":"https://doi.org/10.1111/php.70132","url":null,"abstract":"Candida albicans surface alterations following photodynamic therapy using Raman spectroscopy were studied. Previously effective photosensitizers were tested: 200 μM erythrosine, 100 mM KI, 200 μM erythrosine+100 mM KI irradiated with a 530 ± 10 nm LED (250 mW/cm2, 20 J/cm2 per session for two sessions (total fluence: 40 J/cm2)), 60 M bisdemethoxycurcumin irradiated with a 430-480 nm LED (950 mW/cm2, 75 J/cm2), 100 μM melatonin irradiated with a 630 ± 10 nm LED (250 mW/cm2, 75 J/cm2), and 60 μM bisdemethoxycurcumin+100 μM melatonin with dual light. Treatments were applied to mature C. albicans biofilms. Negative and positive controls were phosphate-buffered saline and nystatin, respectively. Raman spectroscopy used a 50× objective lens, 600 lines/mm grating, and 785 nm laser. Data were analyzed using principal component analysis. Erythrosine and erythrosine+KI induced specific surface alterations with Raman peaks similar to nystatin and differing from the negative control at 625, 1159, 1270, 1336, 1491, and 1603 cm-1.Raman peaks at 625 cm-1 correspond to phenylalanine, 1159 cm-1 to carbohydrate, 1270 cm-1 to amide III, 1336 cm-1 to proteins and carbohydrate, 1491 cm-1 to nucleic acid bases, and 1603 cm-1 to ergosterol. Other treatment groups showed no differences from the negative control. Erythrosine and erythrosine+KI exhibited similar mechanistic cell surface alterations to nystatin.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phototherapies mediated by metallic nanoparticles and near-infrared radiation in skin cancer: A systematic review. 金属纳米粒子和近红外辐射介导的光疗法在皮肤癌中的应用：系统综述。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-30 DOI: 10.1111/php.70129

Tamyris Devincenzi, Alessandra Costa Lopes, Marcelo Augusto Germani Marinho, Daza de Moraes Vaz Batista Filgueira

{"title":"Phototherapies mediated by metallic nanoparticles and near-infrared radiation in skin cancer: A systematic review.","authors":"Tamyris Devincenzi, Alessandra Costa Lopes, Marcelo Augusto Germani Marinho, Daza de Moraes Vaz Batista Filgueira","doi":"10.1111/php.70129","DOIUrl":"https://doi.org/10.1111/php.70129","url":null,"abstract":"Skin cancer remains one of the most prevalent malignancies worldwide, with increasing incidence rates for both melanoma and non-melanoma subtypes. In this context, nanotechnology-based phototherapies have emerged as promising therapeutic strategies. This systematic review aimed to analyze the therapeutic potential of metallic nanoparticles (MNPs) for photodynamic therapy (PDT) and photothermal therapy (PTT) in skin cancer treatment. Three databases were consulted-Scopus, Web of Science, and PubMed; the studies were transferred to the Zotero software, where they were analyzed by the authors according to the predefined inclusion and exclusion criteria. Most of the studies found focus on melanoma. In vitro findings demonstrated significant reductions in cell viability following combined MNPs and near-infrared (NIR) irradiation, predominantly mediated by apoptosis and associated with increased reactive oxygen species (ROS) levels and temperature elevation (△T). In vivo studies confirmed enhanced tumor suppression with combined therapy compared to isolated treatments. Although temperature increments were lower in vivo than in vitro, therapeutic efficacy remained significant. Safety assessments indicated no relevant changes in body weight or histopathological alterations in major organs, suggesting low systemic toxicity. Collectively, ROS generation and photothermally induced hyperthermia represent key mechanisms driving tumor regression. Therefore, MNPs thus emerge as promising and biocompatible photoactive agents for skin cancer treatment with NIR association.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The burning question: Does exposure to low dose and low irradiance ultraviolet radiation lead to cutaneous DNA damage in people with skin types I-III? 迫切的问题：暴露于低剂量和低辐照度的紫外线辐射会导致皮肤类型为I-III的人的皮肤DNA损伤吗？

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-06-29 DOI: 10.1111/php.70120

Montana O'Hara, Gunter Hartel, Scott Byrne, Elke Hacker, Xiaozhun Hang, Olga V Ilinsky, Tanya Ross, Linda Stewart, Nicholas Hayward, Kiarash Khosrotehrani, Craig Sinclair, David C Whiteman, Rachel E Neale

{"title":"The burning question: Does exposure to low dose and low irradiance ultraviolet radiation lead to cutaneous DNA damage in people with skin types I-III?","authors":"Montana O'Hara, Gunter Hartel, Scott Byrne, Elke Hacker, Xiaozhun Hang, Olga V Ilinsky, Tanya Ross, Linda Stewart, Nicholas Hayward, Kiarash Khosrotehrani, Craig Sinclair, David C Whiteman, Rachel E Neale","doi":"10.1111/php.70120","DOIUrl":"https://doi.org/10.1111/php.70120","url":null,"abstract":"Exposing the skin to low (non-burning) doses of ultraviolet radiation (UVR) can avoid vitamin D deficiency, but whether delivering these doses at naturally occurring UVR indices causes DNA damage in humans is unknown. Participants (Fitzpatrick skin type I-III; N = 58) received solar-simulated UVR (0.7 and 1.6 standard erythemal doses, SED) on the lower back on four consecutive days. Doses were delivered at either UVI 2.8 or UVI 8.0. Skin biopsies were collected at baseline, and from exposed sites at 15 min, 24, and 72 h. Immunofluorescent staining assessed the induction of cyclobutane pyrimidine dimers (CPD), P53 expression, and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) damage in epidermal cells. Exposure to 1.6 SED caused a significantly greater increase in the percentage of CPD-positive cells compared with 0.7 SED (e.g., UVI 8: 15 min 3.67% vs. 0.89%, p < 0.0001). Similarly, exposure to the 1.6 SED dose caused greater P53 expression than the 0.7 SED dose; at 72 h there was a 2.5- to 3-fold higher P53 expression in the samples exposed to 1.6 SED. UVR irradiance did not affect CPD or P53 responses. 8-oxodG showed minimal, nonsignificant changes over time. UVR delivered at doses that can maintain adequate vitamin D status, and at naturally occurring irradiance, leads to measurable DNA damage.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0