Photochemistry and Photobiology最新文献

{"title":"Pro-inflammatory roles of ultraviolet radiation in cutaneous photocarcinogenesis.","authors":"Chikako Nishigori","doi":"10.1111/php.70102","DOIUrl":"https://doi.org/10.1111/php.70102","url":null,"abstract":"<p><p>Previously, it was thought that ultraviolet radiation (UV) carcinogenesis was caused by accumulation of mutations related to cancer, including oncogenes and tumor suppressor genes. These genetic changes found in skin cancers are considered to be induced by UV, based on the findings that \"UV-signature mutations\" are predominant. However, recent findings revealed that UV carcinogenesis includes a more complicated process, and the importance of inflammation is emphasized. It is evident that DNA lesions cause inflammation. We showed that Ogg1 knockout mice, which fail to repair 8-OxoG, a representative oxidative DNA lesion, manifest a much higher frequency of UV-induced skin cancers without increasing p53 mutations. Gene expression analysis in this system revealed that 8-oxoG upregulates inflammatory pathway genes. Furthermore, a mice model of xeroderma pigmentosum, a DNA repair disorder, where patients manifest severe sunburn and high frequency of skin cancers, was demonstrated to express an extremely high level of CXCL1, an inflammatory chemokine. Inhibiting CXCL1 decreased the development of UV-induced skin cancers without repairing dipyrimidine photoproducts. Additionally, some anti-inflammatory medicines suppress the development of UV-induced skin cancers. The enhancement of photosensitive medications, including voriconazole and hydrochlorothiazide on UV carcinogenesis, has been indicated both epidemiologically and experimentally.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian regulation of reproduction and neoblast cell division in the catenulid flatworm Stenostomum virginianum (Platyhelminthes).","authors":"Daniel L Stanton, Ian D Deas, J Kennon Smith, Samuel B Robinson, Adam M Reitzel, Julian P S Smith","doi":"10.1111/php.70100","DOIUrl":"https://doi.org/10.1111/php.70100","url":null,"abstract":"<p><p>The molecular circadian clock and melatonin secretion are pivotal for coordinating homeostasis pathways in many animals. Melatonin has been shown to regulate reproduction and neoblast proliferation in triclad flatworms, yet the extent to which these mechanisms operate in other platyhelminths remains unknown. We examined light sensing, endogenous melatonin production, and circadian control of asexual reproduction in the early-branching catenulid Stenostomum virginianum. Microscopy revealed refractile bodies with photoreceptor-like structures, blue-light autofluorescence, and PAX6 immunoreactivity in cells anterior to the brain that support the presence of a photoreceptive system. High-performance liquid chromatography detected endogenous melatonin production in S. virginianum. Exogenous melatonin administered under continuous darkness suppressed reproduction and neoblast mitosis. The same treatment applied at ZT 6 during a 12 h:12 h light-dark cycle failed to affect reproduction, implying a masking or circadian compensatory effect. Phylogenetic analysis identified two broadly conserved bHLH-PAS genes (ARNT) in a transcriptome for S. virginianum; although CLOCK and CRY were not detected, they are present in the closely related Macrostomum lignano, indicating that this absence may be due to an incomplete transcriptome. These findings suggest that circadian rhythms influence reproduction and cell division in S. virginianum, extending our understanding of melatonin-mediated, light-responsive regulation in distinct branches of the platyhelminths.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Plasmonic expectations: Micellar confinement governs the Norrish type I reaction in hybrid micelle-gold nanoparticle systems.","authors":"Nory Mariño-Ocampo, Yousif Rawof, John Vincent Malvar, Jacky Kieu, Belinda Heyne","doi":"10.1111/php.70107","DOIUrl":"https://doi.org/10.1111/php.70107","url":null,"abstract":"<p><p>Spin-dependent photochemical mechanisms are central to understanding how external stimuli, such as light, temperature, and magnetic fields, modulate chemical reactivity. In this study, the photolysis of the asymmetrical ketone 4-methyldibenzyl ketone (MDBK) was investigated in cetyltrimethylammonium chloride (CTAC) micelles and in hybrid gold nanoparticle (AuNP) systems under UVB and combined UVB-red light irradiation. The objective was to assess whether plasmonic AuNPs could alter product distribution or influence radical pathways relative to micellar media alone. Photoproduct analysis revealed that the incorporation of AuNPs did not induce measurable variations in the product ratios, and the calculated cage effect remained comparable to that observed in pure CTAC micelles. This outcome demonstrates that micellar confinement remains the dominant factor controlling radical recombination in MBDK photolysis, even in hybrid plasmonic environments. By defining the regime in which nanoparticle-induced perturbations are negligible, this work provides a mechanistic baseline and guides future efforts to identify conditions conducive to plasmon-radical coupling.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant properties of tauroursodeoxycholic acid towards free radicals revisited.","authors":"Joanna Waresiak, Zanyar Othman Hussein, Andrzej C Żądło, Tomasz M Borowski, Tadeusz J Sarna, Anna M Pawlak","doi":"10.1111/php.70103","DOIUrl":"https://doi.org/10.1111/php.70103","url":null,"abstract":"<p><p>Antioxidant properties of tauroursodeoxycholic acid (TUDCA), a cytoprotective bile acid, toward free radicals-induced oxidation of lipids were studied in different model systems using EPR oximetry, EPR spin trapping and the FOX-2 method. Various generators of free radicals were tested: Victoria Blue as a type I sensitizer with minimal generation of singlet oxygen (Φ_Δ ≈ 0.2%), hydrophilic (Fe(III)-ADP) and hydrophobic (Fe(III)-8HQ) ferric ion complexes and thermolabile, hydrophilic azo compound (AAPH). The rate of free radicals-induced lipid peroxidation was shown to be reduced by TUDCA in the tested systems. The significant efficiency of TUDCA in retarding LOOH accumulation when lipid oxidation was induced by a hydrophobic ferric ion complex suggests that TUDCA is associated with membranes and operates most efficiently in a lipophilic environment. The efficiency of TUDCA to inhibit peroxidation of lipids induced by free radicals generated in a Fenton-type reaction suggests that the compound may chelate iron ions, thereby reducing their redox activity. Calculations performed using the DOCER algorithm support this hypothesis, indicating that the interaction energies of TUDCA with iron ions fall between those of the two reference models: 8HQ- and the ADP-iron ion complex. This confirms an intermediate interaction pattern.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further insights on the antimicrobial effectiveness of far-UVC light.","authors":"Manuela Buonanno, David Welch, Eric Wang, Igor Shuryak, Marilena Aquino de Muro, David J Brenner","doi":"10.1111/php.70104","DOIUrl":"https://doi.org/10.1111/php.70104","url":null,"abstract":"<p><p>The anti-microbial capacity of far-ultraviolet C (UVC) light (200-235 nm) has been shown for a variety of pathogens. There is evidence that far-UVC has limited ability to damage human skin and eyes; therefore, far-UVC fixtures could be used to continuously disinfect occupied indoor spaces and be a practical intervention for pandemic control. Our group has previously shown that 222 nm inactivated aerosolized viruses as well as drug-resistant bacteria when exposed on agar surfaces or in aerosol. This work extends those studies and presents novel findings from a series of experiments conducted over the past five years, all aimed at probing different aspects of the antimicrobial effectiveness of far-UVC light. Specifically, the study (1) describes the susceptibility of human coronavirus OC43 (HCoV OC43) exposed on a plastic surface to different sources of far-UVC; (2) describes the survival of clinical bacterial isolates exposed to 222 nm on agar surfaces; (3) evaluates a suitable surrogate of human viruses exposed to 222 nm in aerosol; (4) compares the inactivation of HCoV OC43 exposed to 222 nm on surfaces, aerosol, or in aqueous solution. By integrating complementary observations, the results contribute further evidence supporting the effectiveness of far-UVC against pathogens exposed under different laboratory conditions.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of photobiomodulation therapy on pulmonary inflammation in chronic asthma: Dosimetric study in an experimental model.","authors":"Tawany Gonçalves Santos, Cintia Estefano Alves, Bibiana Padilha de Menezes da Silva, Cinthya Cosme Gutierrez Duran, Stella Zamuner, Rodrigo Labat, José Antonio Silva Junior, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira","doi":"10.1111/php.70094","DOIUrl":"https://doi.org/10.1111/php.70094","url":null,"abstract":"<p><p>Photobiomodulation therapy (PBMT) has emerged as a non-invasive therapeutic approach with anti-inflammatory and immunomodulatory potential in respiratory diseases. However, the optimal radiant energy required to achieve effective modulation of chronic airway inflammation remains unclear. This study aimed to investigate the effects of photobiomodulation therapy using different radiant energy doses on pulmonary inflammation, airway remodelling, and immune response in a murine model of chronic asthma induced by ovalbumin (OVA). Chronic allergic pulmonary inflammation was established through subcutaneous sensitization with OVA followed by repeated orotracheal challenges over 5 weeks. After each challenge, animals were treated with a 660 nm continuous-wave diode laser at irradiation times of 10, 30, 50, and 75 s, corresponding to radiant energies of 1, 3, 5, and 7.5 J, respectively. Twenty-four hours after the final challenge, pulmonary inflammation was assessed by cellular analysis of bronchoalveolar lavage fluid, cytokine quantification, histomorphometric evaluation of airway remodelling, and immunophenotyping of regulatory T cell populations. Photobiomodulation therapy significantly attenuated pulmonary inflammation by reducing eosinophil, neutrophil, and lymphocyte recruitment, as well as decreasing pro-inflammatory cytokine levels, including interleukin (IL)-4, IL-5, and IL-13. In parallel, PBMT increased levels of the anti-inflammatory cytokine IL-10 and promoted an expansion of regulatory immune cell subsets, including CD4⁺CD25⁺Forkhead box P3 (Foxp3)⁺ and CD4⁺IL-10⁺ cells, indicating a marked immunomodulatory effect. In addition, PBMT reduced mucus production and collagen deposition in the airways, with the most pronounced effects observed at radiant energies of 3 and 5 J. These findings demonstrate that photobiomodulation therapy, particularly at intermediate radiant energy doses, effectively modulates immune responses, attenuates airway remodelling, and reduces chronic pulmonary inflammation in experimental asthma.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface: Special memorial issue dedicated to Kendric Smith.","authors":"Albert Girotti, David Kessel, Tayyaba Hasan, Alexander Greer","doi":"10.1111/php.70101","DOIUrl":"https://doi.org/10.1111/php.70101","url":null,"abstract":"","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zebrafish as a practical and convenient model for the study of photodynamic and photothermal therapy of solid tumors: A scoping review.","authors":"Ethan Wilson, Alexander Fiorentino, Brian W Booth, Valery Bliznyuk, Diana Ivankovic, Luigi Boccuto","doi":"10.1111/php.70096","DOIUrl":"https://doi.org/10.1111/php.70096","url":null,"abstract":"<p><p>Thanks to incalculable efforts by teams of scientists and physicians over the past half-century, many cancer diagnoses that would have previously seemed terminal are now considered treatable or even curable with optimization of existing treatment strategies and the introduction of novel treatment methodologies. One rising treatment paradigm with the potential to improve patient outcomes and experiences is photomedicine, a group of light-activated treatments that can be applied systemically and activated locally. As the work of developing new phototherapeutic treatments and agents for use in cancer patients progresses, in vivo experimentation is a necessary hurdle, costing both time and resources. The use of zebrafish as a vertebrate tumor model for early-stage animal testing has the potential to increase the overall efficiency of the research process. Zebrafish are a model organism that allow for numerous tumor presentations and drug-delivery options to be tested at scale with a low turnaround time relative to other in vivo vertebrate models. The transparency of an embryonic or larval zebrafish's body allows for real-time observation of drug dispersal and effects of treatment. These qualities allow zebrafish to serve as a useful screening tool for identifying promising candidate photosensitizers before embarking on mammalian studies.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochrome-mediated shade-avoidance responses and its impact on growth and physiology in crops-A review.","authors":"Konappan Surya, Ramanujam Krishnan, Vaddi Saitheja, Ponnusamy Janaki, Ettiyagounder Parameswari, Govindan Senthil Kumar, Muthaiyan Gnanachitra, Koppula Suresh, Ratchagar Arockia Infant Paul, Ammaiyappan Anbazhagan","doi":"10.1111/php.70098","DOIUrl":"https://doi.org/10.1111/php.70098","url":null,"abstract":"<p><p>Shade stress is a critical environmental constraint that significantly affects plant growth, development, and productivity. Phytochromes, as red and far-red light photoreceptors, play a central role in perceiving shading signals and orchestrating complex physiological and molecular responses in crops. This review provides an analysis of phytochrome-mediated shade stress, highlighting its impacts on key plant processes such as photosynthesis, hormonal regulation, gene expression, and biomass accumulation. We discuss the roles of red and far-red light in modulating phytochrome activity and downstream signaling pathways, emphasizing how these photoreceptors interact with hormonal networks to influence plant morphology, flowering, and stress adaptation. The phytochrome signaling cascade involves intricate light perception and gene regulatory mechanisms that enable plants to adjust their growth under low-light conditions. Differential responses of C₃ and C₄ plants to shade stress are also examined, revealing species-specific strategies for coping with reduced light intensity. Moreover, the review outlines current approaches for managing shading stress, including agronomic practices, genetic interventions, and molecular breeding strategies aimed at enhancing light-use efficiency. By synthesizing recent findings, this article provides insights into the functional roles of phytochromes in mediating shade avoidance and tolerance, offering a framework for future research on crop adaptation to heterogeneous light environments. Understanding phytochrome-mediated mechanisms is crucial for developing resilient cropping systems that maintain productivity under suboptimal light conditions.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into pterin-photosensitized oxidation of 2'-deoxyadenosine 5'-monophosphate.","authors":"Mariana P Serrano, Gricelda Godoy-Ortega, Jael R Neyra Recky, Mariana Vignoni, Andrés H Thomas, Carolina Lorente","doi":"10.1111/php.70091","DOIUrl":"https://doi.org/10.1111/php.70091","url":null,"abstract":"<p><p>DNA and its components, the nucleotides, are susceptible to oxidation, which alters normal cellular development and functioning, including the formation of mutations and the appearance of cancerous processes. Therefore, the study of the mechanisms involved in the oxidation of these molecules is relevant to prevent damage to genetic material. Electromagnetic radiation causes damage to DNA triggering the oxidation of all nucleobases, with guanine being the most affected. Depending on the wavelength, UV radiation can cause direct or photosensitized damage to DNA and its components; however, since solar radiation has wavelengths greater than 300 nm and is not absorbed by nucleobases, the primary damage is photosensitized. Here, we are presenting new evidence on the photosensitized oxidation of the adenine nucleotide, 2'-deoxyadenosine 5'-monophosphate (dAMP). Pterin is used as a model photosensitizer since it is present in all living systems and absorbs radiation in the UV-A region, the main UV component in solar radiation. We analyze the mechanisms involved and the role of superoxide anion (O₂ ^•-), evidencing that this reactive oxygen species protects dAMP by recovering the nucleotide after one-electron oxidation. Oxidation product analysis revealed the formation of 2'-allantoin-5´monophosphate (dAlMP).</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}