Silvia Ximena Barrios Martínez, Diego Armando Villamizar Mantilla, Nathaly Hernández-Díaz, Lady Johanna Sierra, Raquel Elvira Ocazionez, Elena E Stashenko, María Pilar Vinardell, Jorge Luis Fuentes
{"title":"In vitro and in vivo protective effects of a phytochemical mixture (Posoqueria latifolia extract + Kaempferol) against UVB-induced radiation damage.","authors":"Silvia Ximena Barrios Martínez, Diego Armando Villamizar Mantilla, Nathaly Hernández-Díaz, Lady Johanna Sierra, Raquel Elvira Ocazionez, Elena E Stashenko, María Pilar Vinardell, Jorge Luis Fuentes","doi":"10.1111/php.14086","DOIUrl":"https://doi.org/10.1111/php.14086","url":null,"abstract":"<p><p>Plants may be a source of protective compounds that inhibit injuries caused by overexposure to solar radiation. Present work evaluated the protective effects of a phytochemical mixture based on Posoqueria latifolia extract + Kaempferol against ultraviolet-induced radiation DNA damage in human fibroblasts and mice skin. Cytotoxicity, genotoxicity, and antigenotoxicity of P. latifolia flower extract, Kaempferol, and the mixture of both were studied in MRC5 human fibroblasts using Trypan blue exclusion and Comet assays. Kinetics of DNA damage repair post irradiation, in the presence and absence of the phytochemicals, were also evaluated. The inhibition of UVB-induced erythema and cyclobutene pyrimidine dimers (CPD) by the phytochemicals and the mixture were also investigated in mice skin. We showed that the P. latifolia flower extract, Kaempferol, and the mixture inhibited UVB-induced DNA damage and increased DNA repair mechanisms in human fibroblasts. In addition, these phytochemicals inhibited the UVB-induced erythema and CPD in mice skin. The potential of the studied phytochemicals in human photoprotection was discussed.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Dushkin, Afanasiev Maxim, Svitich Oxana, Afanasiev Stanislav, Grishacheva Tatyana, Kukina Polina, Asmik Avagyan, Irina Dushkina, Elena Biryukova, Akmaral Khangeldi, Alexander Karaulov
{"title":"Effect of photodynamic therapy on the expression of toll-like receptor 2, -3, -4, and -8 in the cervical lesions.","authors":"Alexander Dushkin, Afanasiev Maxim, Svitich Oxana, Afanasiev Stanislav, Grishacheva Tatyana, Kukina Polina, Asmik Avagyan, Irina Dushkina, Elena Biryukova, Akmaral Khangeldi, Alexander Karaulov","doi":"10.1111/php.14093","DOIUrl":"https://doi.org/10.1111/php.14093","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is a minimally invasive treatment with low systemic toxicity and immunomodulatory effects, increasingly applied in managing HPV-associated cervical lesions. Toll-like receptors (TLRs) are critical in regulating immune responses in cervical pathology, yet their dynamics under PDT remain underexplored. This study investigates the effect of PDT on TLR2, TLR3, TLR4, and TLR8 expression in cervical epithelial cells ex vivo, considering lesion severity. The results reveal that TLR8 exhibited the most significant reduction across all groups 2 h after PDT, with the strongest suppression in patients with invasive cervical cancer. TLR4 expression decreased by 24% in HPV-infected patients and by 71% in those with cervical cancer, highlighting its potential role in modulating the inflammatory microenvironment post-PDT. TLR3 showed hyperexpression in LSIL and suppression in HSIL/CIN III, although changes were not statistically significant (p > 0.05). TLR2 expression remained unchanged, likely due to HPV type variability. These findings demonstrate that PDT effectively reduces hyperexpression of TLR8, TLR4, and TLR3 in early-stage cervical cancer, suggesting their potential as biomarkers for treatment efficacy. Further research incorporating HPV typing and advanced techniques like liquid biopsy is essential to refine our understanding of TLRs in PDT for HPV-associated cervical lesions.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selly S Suzuki, Amanda M Ribeiro, Marcella U R Fernandes, Chooryung Chung, Aguinaldo S Garcez
{"title":"Enhancing bone remodeling and accelerating tooth movement with photobiomodulation in middle-aged adults.","authors":"Selly S Suzuki, Amanda M Ribeiro, Marcella U R Fernandes, Chooryung Chung, Aguinaldo S Garcez","doi":"10.1111/php.14089","DOIUrl":"https://doi.org/10.1111/php.14089","url":null,"abstract":"<p><p>Although age is not a contraindication for orthodontic treatment, it can be considered more challenging in mature adult patients, mainly due to a less responsive bone metabolism and reduced osteoblastic activity compared to young patients. In orthodontics, photobiomodulation (PBM) has shown positive results in bone remodeling during tooth movement. This study seeks to assess the effect of PBM can have a positive effect on bone remodeling, stimulating bone formation in middle-aged individuals and allowing for a better periodontal condition. Bone structure and the length of the roots were evaluated using cone beam computed tomography images before and after tooth movement and PBM in patients aged between 40 and 60 years. In addition, we aimed to evaluate the expression of the markers receptor activator of NFκB (RANK), osteoprotegerin (OPG), and osteopontin (OPN) presented in the crevicular fluid using the enzyme-linked immunosorbent assay test. Tooth movement was performed by intruding upper molars with two mini-implants as anchorage bilaterally. One side received PBM with light-emitting diode (LED) light and the contralateral side was used as control (no irradiation). The PBM equipment specially designed for this study consisted of six LEDs of 5 mW each, for 7 minutes, totaling 2 J, 3 times a week, for 5 months. The PMB group showed greater tooth movement (p < 0.05), an increase of 74% on average for bone height. PBM induced a significant increase in RANK expression at month 3 (p < 0.05), and the expression of OPG and OPN showed a significant increase in the fifth month of movement (p < 0.05) in the PBM group. PBM may represent an adjunct therapeutic approach during tooth movement in more mature patients, leading to a more responsive bone metabolism and favoring more comprehensive orthodontic treatment.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Darrian S Hawryluk, Martin S Pavelka, Timothy M Baran
{"title":"Susceptibility of bacterial species commonly found in abdominal abscesses to low-dose photodynamic therapy: Effects of methylene blue concentration, fluence rate, and fluence.","authors":"Darrian S Hawryluk, Martin S Pavelka, Timothy M Baran","doi":"10.1111/php.14092","DOIUrl":"https://doi.org/10.1111/php.14092","url":null,"abstract":"<p><p>The objective of this study was to determine the effects of methylene blue (MB) concentration, laser fluence rate, and laser fluence on the efficacy of in vitro photodynamic therapy (PDT) for four bacteria commonly found in human abscesses. PDT experiments were performed with four of the most common bacteria found in abdominal abscesses: Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa. MB concentration was varied from 50 to 300 μg/mL, and the laser fluence rate was varied from 1 to 4 mW/cm<sup>2</sup> at a fluence of 7.2 J/cm<sup>2</sup>. Higher fluence rates and fluences were explored for P. aeruginosa. Primary outcomes were the reduction in colony-forming units (CFU) following PDT and measured MB uptake following drug incubation. Gram-positive bacteria (E. faecalis and S. aureus) were eradicated at all MB concentrations and laser fluence rates tested. Efficacy was reduced for E. coli but still resulted in >6 log<sub>10</sub> reduction in CFU when MB concentration was at least 100 μg/mL. P. aeruginosa required higher fluence (28.8 J/cm<sup>2</sup>) to achieve comparable efficacy, while increasing fluence rate did not have a significant effect on PDT efficacy. MB uptake was reduced in Gram-negative species compared to Gram-positive species, particularly P. aeruginosa, although uptake was not significantly correlated with CFU reduction. Gram-positive bacteria can be eradicated in vitro with low levels of MB (50 μg/mL), laser fluence (7.2 J/cm<sup>2</sup>), and laser fluence rate (1 mW/cm<sup>2</sup>). E. coli showed substantial cell killing (>6 log<sub>10</sub> CFU reduction) with these same parameters. Low MB uptake and PDT efficacy in P. aeruginosa could be overcome by increasing the laser fluence, while increasing fluence rate did not have an effect.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam J Greer, Sean J Cone, Rachel Bernstein, Elizabeth Schuetz, Narayani Prasad Kar, Bala S C Koritala, Shobhan Gaddameedhi
{"title":"Long-term sub-erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions.","authors":"Adam J Greer, Sean J Cone, Rachel Bernstein, Elizabeth Schuetz, Narayani Prasad Kar, Bala S C Koritala, Shobhan Gaddameedhi","doi":"10.1111/php.14081","DOIUrl":"https://doi.org/10.1111/php.14081","url":null,"abstract":"<p><p>The International Agency for Research on Cancer (IARC) stated that circadian disruption is a potential carcinogen. However, the impact of environmental carcinogens, including sub-erythemal doses of UVB exposure, on circadian rhythms remains unclear. We evaluated the impact of long-term rotating shift, loss of Per1/2 genes, and chronic UVB exposure on the circadian rhythms of SKH-1 mice for up to 7 months. Real-time locomotion and circadian gene expression were measured in these animals. Mice under rotating shift exhibited a longer period of activity of up to 25.20 h, while those under standard light conditions had a clear 24-h rhythm. mPer1/mPer2 mice, conversely, displayed a shortened period of activity of 23.61 h. Interestingly, chronic UVB exposure had no impact on activity rhythms, though it induced skin tumors in all mice. Rotating shift and loss of mPer1/mPer2 led to circadian dysregulation of all core clock genes, with a notable phase difference in Cry1. These findings provide novel insights into environmental and genetic influences on circadian rhythms.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decomposition of water over Picene-derivatized photocatalysts under visible light irradiation.","authors":"Hayato Shiroma, Yusuke Motoyama, Hiroshi Danjo, Yuichi Ichihashi","doi":"10.1111/php.14094","DOIUrl":"https://doi.org/10.1111/php.14094","url":null,"abstract":"<p><p>Inorganic semiconductors such as TiO<sub>2</sub> absorb ultraviolet light to promote reactions. However, sunlight consists mainly of visible light, and so the development of photocatalysts that can use visible light is being actively researched. Density functional theory (DFT) calculations previously showed that the introduction of formyl, carboxyl, and carboxyethyl groups into picene can absorb visible light and generate hydrogen via the decomposition of water. In this study, these substituted picene derivatives were employed as photocatalysts, and their water photolysis activities were evaluated under visible light irradiation. All three picene derivatives were active photocatalysts, with hydrogen production activities decreasing in the order of: picene-13-carbaldehyde (CHO-picene) > picene-13-carboxylic acid (COOH-picene) ≈ Ethyl picene-13-carboxylate (COOEt-picene) > picene. Subsequently, the effects of the three functional groups on the hydrogen production activity in the water photolysis reaction were investigated in further detail. The effects of the functional groups were found to be in accordance with the Hammett equation, wherein a greater electron-withdrawing property led to a higher hydrogen production activity.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elia Francesco Vedda, Heloísa Alonso Matielo, Mariana Corrêa Sousa, Victhor Teixeira de Oliveira, Victória Regina da Silva Oliveira, Adilson Silva Alves, Luiz Roberto Giorgetti Britto, Camila Squarzoni Dale
{"title":"Reversal of allodynia and enhanced tendon repair in rats via 660 and 808 nm photobiomodulation.","authors":"Elia Francesco Vedda, Heloísa Alonso Matielo, Mariana Corrêa Sousa, Victhor Teixeira de Oliveira, Victória Regina da Silva Oliveira, Adilson Silva Alves, Luiz Roberto Giorgetti Britto, Camila Squarzoni Dale","doi":"10.1111/php.14082","DOIUrl":"https://doi.org/10.1111/php.14082","url":null,"abstract":"<p><p>Our study aimed to explore the potential of Photobiomodulation (PBM) as a treatment for Tendinopathy (TP), a chronic condition characterized by tendon degeneration, inflammation, and pain, for which current treatment options often yield unsatisfactory outcomes. PBM, utilizing low-level laser, has shown promise in reducing inflammatory markers, stimulating cell proliferation, and alleviating pain, thus presenting itself as a promising alternative therapy for TP. Using an experimental rat model of tendinopathy, male Wistar rats weighing 250-370 g were induced with TP through the injection of type I collagenase into the calcaneal tendon. Animals were divided into four equal groups (control, TP, TP + 660 nm, TP + 808 nm), with 10 animals in each group for the nociceptive behavioral tests and 5 in each for the biomolecular analysis. Fifteen days later, PBM was administered to the tendons once daily for seven consecutive sessions using two wavelengths (660 and 808 nm), with 3 J for 30 s, irradiating an area of 0.028 cm<sup>2</sup> totaling 107.14 J/cm<sup>2</sup>. Mechanical nociception and thermal cold sensitivity were assessed, and tendon samples were collected for analysis of collagen types and total cell count. Spinal cord samples were also collected and immunostained to evaluate specific markers. Our results demonstrated that collagenase injection induced mechanical allodynia and cold hypersensitivity, both of which were reversed by PBM at both 660 and 808 nm wavelengths (**p < 0.005 and *p < 0.05). Additionally, TP led to an increase in collagen type III and a decrease in collagen type I expression, with these effects being reversed by PBM treatment (*p < 0.05). Moreover, TP increased astrocyte immunoreactivity, while PBM at both wavelengths led to a decrease in astrocyte and IL-1β expression. In conclusion, PBM emerged as an effective treatment for TP, as it not only alleviated pain symptoms but also modulated collagen expression and reduced astrocyte and IL-1β expression (**p < 0.01). These findings suggest that PBM could serve as a beneficial adjunctive therapy for analgesia and regeneration in TP management.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modulation of the fluorescence of graphene oxide micro-flakes with addition of peripheral benzimidazole group.","authors":"Henrique Luiz Berthault Moura, Marcelo Henrique Gehlen","doi":"10.1111/php.14087","DOIUrl":"https://doi.org/10.1111/php.14087","url":null,"abstract":"<p><p>Graphene oxide (GO) is peripherally modified with the addition of 4-(1H-benzimidazol-2-yl) benzaldehyde using a Debus-Radziszewski reaction with its ortho-quinone groups. The GO content of ortho-quinone is enhanced by the oxidation of catechol groups using molybdic acid in a Froehde reaction. Following a Knoevenagel condensation of the peripherally substituted benzimidazole with methyl cyanoacetate, a fluorescent intramolecular charge-transfer (ICT) chromophore is introduced in the GO structure, forming a new fluorescent material called GO-BI (graphene oxide with benzimidazole). Its micro-flake particle has emission concentrated in its border, as revealed by confocal and total internal reflection fluorescence microscopy (TIRFM) images. The emission spectrum of the GO-BI micro-particle is centered on 525 nm and the fluorescence decay is biexponential, with two main components of 1.6 and 7.0 ns when excited at 473 nm.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of 807-nm light-emitting diode photobiomodulation on peripheral nerve injury.","authors":"Biao Chang, Qi Quan, Xinyue Liang, Yanjun Guan, Xing Xiong, Haixia Qiu, Jing Zeng, Yidi Liu, Ying Wang, Jiang Peng, Ying Gu","doi":"10.1111/php.14090","DOIUrl":"https://doi.org/10.1111/php.14090","url":null,"abstract":"<p><p>Photobiomodulation (PBM) has demonstrated potential in promoting peripheral nerve regeneration. However, there is a limited and inconclusive study on the application of light-emitting diode (LED) for nerve injury repair. In this study, we designed an 807-nm LED device with high luminous uniformity to investigate the effects of LED-based PBM on peripheral nerve injury repair. RSC96 cells were utilized as the target cells and optimal light parameters were selected based on ATP concentration, CCK-8 assays, PCR, and immunofluorescent staining. One-way analysis of variance and Student's t-test was used for statistical tests. LED irradiation at 10 mW/cm<sup>2</sup> for 30 min effectively enhanced Schwann cell proliferation, neurotrophic factor secretion, and MBP synthesis. To translate the cellular light parameters for animal studies, the transmittance through freshly obtained rat skin and biceps femoris muscle was assessed, and the transmittance was approximately 30%. After directly daily irradiating the sciatic nerve injury area in rats for 21 days at 33 mW/cm<sup>2</sup> for 30 min, we used gait analysis, immunofluorescence staining, muscle wet weight ratio, Masson staining, and transmission electron microscopy to evaluate nerve recovery. LED irradiation significantly improved sciatic nerve index, increased MBP staining intensity, and enhanced myelin sheath thickness, nerve diameter, and axon diameter. These results indicated the feasibility of LED-based PBM as a treatment method for peripheral nerve injuries.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brittany P Rickard, Lauren A Sapienza-Lundie, Marta Overchuk, Xianming Tan, Victoria L Bae-Jump, Melinda S Yates, Suzanne E Fenton, Imran Rizvi
{"title":"Photodynamic priming overcomes platinum resistance from short-term exposure to select perfluoroalkyl substances in endometrial cancer cell lines.","authors":"Brittany P Rickard, Lauren A Sapienza-Lundie, Marta Overchuk, Xianming Tan, Victoria L Bae-Jump, Melinda S Yates, Suzanne E Fenton, Imran Rizvi","doi":"10.1111/php.14073","DOIUrl":"https://doi.org/10.1111/php.14073","url":null,"abstract":"<p><p>First-line treatment for advanced-stage or recurrent endometrial cancer consists of platinum- and taxane-based chemotherapy, to which many patients will develop resistance. Determining the factors that contribute to platinum resistance and developing alternate treatment options for patients with advanced-stage gynecologic malignancies is critical to improving survival outcomes. Recently, we published the first study evaluating the contribution of perfluoroalkyl substances (PFAS) exposure to platinum resistance in endometrial cancer cell lines and found that select PFAS induce carboplatin resistance, potentially by dysregulating mitochondrial function. The present study expands upon those findings by examining the efficacy of photodynamic priming (PDP) in combination with carboplatin to overcome PFAS-induced platinum resistance. Due to the suspected role of mitochondrial dysfunction in platinum resistance, two clinically approved photosensitizers that, in part, localize to mitochondrial membranes or are synthesized in mitochondria were evaluated: benzoporphyrin derivative (BPD) and aminolevulinic acid-induced protoporphyrin IX (ALA-PpIX), respectively. Combination of ALA-PpIX-mediated PDP + carboplatin resulted in a greater reduction in survival fraction than the same combination with BPD. While PDP with both photosensitizers reduced mitochondrial membrane potential, the reduction was greater with BPD-PDP than ALA-PpIX-PDP. These findings demonstrate that BPD-PDP and ALA-PpIX-PDP in combination with carboplatin can be used to overcome PFAS-induced platinum resistance in endometrial cancer cells.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}