Sarah Chamberlain, Ge Shi, Sandra Sexton, Alisher Talgatov, Saraswati Pokharel, David Bellnier, Alan Hutson, Colin G Cameron, Girgis Obaid, Sherri A McFarland, Gal Shafirstein
{"title":"Image-based treatment planning for TLD1433 mediated intraoperative photodynamic therapy with an optical surface applicator-A translational rodent study.","authors":"Sarah Chamberlain, Ge Shi, Sandra Sexton, Alisher Talgatov, Saraswati Pokharel, David Bellnier, Alan Hutson, Colin G Cameron, Girgis Obaid, Sherri A McFarland, Gal Shafirstein","doi":"10.1111/php.14101","DOIUrl":"https://doi.org/10.1111/php.14101","url":null,"abstract":"<p><p>Several clinical studies suggest that following surgical resection, intraoperative photodynamic therapy (intraoperative PDT) has the potential to reduce local recurrence and improve overall survival in patients diagnosed with pleural dissemination of lung cancer. The response to intraoperative PDT depends on the light dose rate (irradiance) and dose (fluence) as well as the intratumoral concentration of the photosensitizer and oxygenation. We seek to advance intraoperative PDT by improving the control of irradiance and fluence with image-based treatment planning for an optical surface applicator (OSA) with a novel photosensitizer (TLD1433) that has shown safety in recent clinical trials. To that end, we tested the accuracy of Monte Carlo-based simulations of light delivery from the OSA in vitro and in vivo. We assess the safety and biodistribution after the instillation of TLD1433 in the peritoneal cavity of mice and rats, and define the relationship between the intratumoral irradiance and fluence, and the volume of tumor ablation in the peritoneal cavity of rats. The Monte Carlo simulations agreed with light dosimetry measurements at a 5-mm prescription depth in vitro. An instillation of TLD1433 in the peritoneal cavity of mice is safe and leads to drug accumulation in the tumor and adjacent organs in the peritoneal cavity of rats. A TLD1433-mediated intraoperative PDT procedure using an instilled dose of 14 mg/kg and 532-nm laser light induces tumor cell degradation in the peritoneal cavity of rats. Our results suggest that the Monte Carlo simulation can be used as an image-based treatment plan for administering a controlled PDT procedure with OSA and TLD1433.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment planning evolution: Comparing approaches in photodynamic and radiation therapies.","authors":"Tina Saeidi, Azin Mirzajavadkhan, Lothar Lilge","doi":"10.1111/php.14071","DOIUrl":"https://doi.org/10.1111/php.14071","url":null,"abstract":"<p><p>The setups of previous and ongoing clinical trials are based on prescribed PDT doses, PS concentration, and light intensity derived from averages of previous clinical or study populations. It is understood that monitoring of personalized PS and light dose is needed to improve PDT outcomes. Monitoring of photophysical, photochemical, or cytotoxic moieties is common, representing concepts of delivered, absorbed, or equivalent doses similar to those used in radiation therapy (RT). Unlike RT, these dose concepts are not equally well developed and standardized across the PDT clinical indications; however, there is potential to improve PDT treatment setup, planning, and delivery by leveraging methodologies from RT. This review summarizes dose definitions and advancements in RT treatment planning and presents the equivalent dose concepts for PDT, particularly how these concepts can expand on the existing methods for PDT treatment planning. By identifying the major limitations and areas for improvement in PDT planning, the hope is to stimulate preclinical and clinical research studies that can enhance the efficacy of PDT, improving patient outcomes.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caradee Y Wright, Nathan J Downs, Thandi Kapwata, David Jean du Preez, Bianca Tod
{"title":"Linking the Ultraviolet Index to the \"shadow rule\" for sun protection: A theoretical model applied with a southern hemisphere example.","authors":"Caradee Y Wright, Nathan J Downs, Thandi Kapwata, David Jean du Preez, Bianca Tod","doi":"10.1111/php.14116","DOIUrl":"https://doi.org/10.1111/php.14116","url":null,"abstract":"<p><p>Personal solar ultraviolet radiation (UVR) exposure has positive and negative impacts on human health. Excess solar UVR exposure can be avoided through safe sun practices such as using sun protection and avoiding unprotected outdoor exposure when solar UVR levels are high. The shadow rule indirectly determines the sun's altitude by observing the length of a person's shadow during the course of the day. When the shadow cast by the sun on a horizontal surface is shorter than the height of the person casting the shadow, the solar UVR intensity is high and is deemed to have more risk. The magnitude of this risk depends on factors such a skin type, sun protection used etc. The UV Index is a standardized measure to describe the intensity of solar UVR with respect to the human action spectrum for sunburn. It is frequently reported in weather forecasts aimed at the public. Here, we demonstrate the potential utility of the shadow rule and how it may be understood in relation to the UV Index in a subtropical southern hemisphere setting. Its use as a simple awareness tool for sun protection in locations where the UV Index is not made public has value in promoting sun exposure awareness and reducing personal exposure risk.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Welch, Manuela Buonanno, Camryn Petersen, Igor Shuryak, Thomas Filler, Neysha Lobo-Ploch, David J Brenner
{"title":"Virus inactivation and skin safety studies using far-UVC LEDs.","authors":"David Welch, Manuela Buonanno, Camryn Petersen, Igor Shuryak, Thomas Filler, Neysha Lobo-Ploch, David J Brenner","doi":"10.1111/php.14115","DOIUrl":"https://doi.org/10.1111/php.14115","url":null,"abstract":"<p><p>Reducing airborne disease transmission is a public health goal. Far-UVC light, defined as 200-235 nm, is a promising technology to inactivate viruses within occupied spaces. This work examines state of the art far-UVC emitting LEDs, with a center emission wavelength of 233 nm, for virus inactivation efficacy and for DNA damage to skin models. The LEDs were used to expose an aerosolized surrogate of SARS-CoV2, the human coronavirus OC43, and survival results estimated a susceptibility constant of k<sub>233-aerosol</sub> = 4.0 ± 0.2 cm<sup>2</sup>/mJ, which corresponds to a D<sub>90</sub> of 0.58 mJ/cm<sup>2</sup>. HCoV-OC43 was also exposed after drying on a plastic or glass surface, and inactivation results estimated susceptibility values of k<sub>1_233-plastic</sub> = 6.7 ± 3.8 cm<sup>2</sup>/mJ and k<sub>1_233-glass</sub> = 7.2 ± 3.0 cm<sup>2</sup>/mJ which were not significantly different. For safety evaluation, human skin biopsies exposed to 100 mJ/cm<sup>2</sup> from the 233 nm LEDs indicated only 8% of the epidermal cells were positive for DNA damage, whereas the same dose from a 254 nm lamp showed damage in 45% of epidermal cells. A radiant exposure of 100 mJ/cm<sup>2</sup> from the 233 nm LEDs did not produce DNA double strand breaks within the skin biopsies. These tests for the safety and efficacy of a 233 nm far-UVC LED system provide support for the continued development of far-UVC LED sources.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alois W Schmalwieser, Hannah Danhel, Susanne S Schmalwieser, Sonja Reimoser, Hanna Rummel, Adrian Loy, Jakob Heydenreich, Philipp Weihs
{"title":"Erythemal UV radiation exposure during jogging.","authors":"Alois W Schmalwieser, Hannah Danhel, Susanne S Schmalwieser, Sonja Reimoser, Hanna Rummel, Adrian Loy, Jakob Heydenreich, Philipp Weihs","doi":"10.1111/php.14114","DOIUrl":"https://doi.org/10.1111/php.14114","url":null,"abstract":"<p><p>Jogging is one of the most popular recreational sport activities over four decades and is done at almost all ages to keep fitness and health. Joggers are exposed to solar UV radiation (UVR) and, due to enhanced heat production by physical activity, body coverage by clothes is reduced. This may imply a health risk due to overexposure. However, little research has been undertaken so far to estimate UVR exposure during jogging. Therefore, UVR exposure was measured at seven body sites during jogging under cloud-free conditions for solar elevations between 20° and 60°. Results show that the top of the shoulder is the most exposed body site by receiving 80% of ambient UVR on average and up to 110% under certain conditions. All other body parts receive up to 55% on average and up to 85% in special cases. This indicates further that monotonous body alignment to the sun holds a higher risk than a frequently alternating alignment. Assuming the longest recommended duration for cardiovascular beneficial jogging of 50 min, photosensitive persons need protection of the shoulders from a UV index of 2 onward on an unvaried path and from a UV index of 3 on an all-directional path. Further, results show that measurements of UVR exposure possess an uncertainty of ±15% including mounting.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of photobiomodulation therapy on implant stability: A systematic review and meta-analysis.","authors":"Mahnaz Arshad, Yekta Mazidi, Nasim Chiniforush, Armin Shirvani, Seyed Hossein Bassir","doi":"10.1111/php.14033","DOIUrl":"10.1111/php.14033","url":null,"abstract":"<p><p>This study was designed to determine the effect of photobiomodulation therapy on dental implant stability. A complete systematic search was performed in PUBMED/MEDLINE, COCHRANE library databases, EMBASE, SCOPUS, and Google Scholar databases on articles published until June 2024. All the RCTs and CCTs reported the solo impact of photobiomodulation on dental implant stability in humans were included. The means and standard deviation for implant stability and sample size were extracted for the meta-analysis. The statistical analysis was conducted using Stata 17 software, and random effect models were applied to assess the source of heterogeneity. The I2 statistic was used to estimate the significance of any discrepancies in the therapy result. After a full-text inspection, 17 articles were qualified for systematic review, and 14 were included in the meta-analysis. Statically significant differences in implant stability were observed between the laser and the control groups on weeks 2 in ISQ reporting groups (p = 0.01, CI 95%) and weeks 4 and 8 in PTV reporting groups (p < 0.001, CI 95%). Despite limitations, the study suggests that PBM therapy benefits patients with dental implants at different periods, particularly during the early phases of healing.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"709-727"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to \"Methylene Blue/Carbon Dots Composite with Photothermal and Photodynamic Properties: Synthesis, Characterization, and Antibacterial Application\".","authors":"","doi":"10.1111/php.14102","DOIUrl":"10.1111/php.14102","url":null,"abstract":"","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"782-784"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Roblin, Christelle Moyen, Pierrette Fleurat-Lessard, Fabienne Dédaldéchamp
{"title":"Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals.","authors":"Gabriel Roblin, Christelle Moyen, Pierrette Fleurat-Lessard, Fabienne Dédaldéchamp","doi":"10.1111/php.14046","DOIUrl":"10.1111/php.14046","url":null,"abstract":"<p><p>The Mimosa pudica leaf has motor organs allowing movements driven by cell osmotic changes in the parenchyma cells in response to various stimuli. Short white light pulses induce rapid and large seismonastic-like movements (denoted \"photostimulation\") of the primary pulvini in various leaves within 120 s after the onset of light. An early event recorded is a wavelength-related modification of the plasma membrane difference: potential depolarization under white, blue, green, and red wavelengths, and hyperpolarization under far red wavelengths (and also in darkness). The photoreactivity of the pulvini is controlled by a circadian rhythm and modulated by the applied diurnal photoperiod cycle (photophase ranging from 6 to 18 h). The reactivity varied among plants and even between leaves on the same plant. The level of reactivity is related to the photon fluence rate in the range from 10 to 140 μmol m<sup>-2</sup> s<sup>-1</sup> under white light and to the experimental temperature in the range 15°C-35°C. An \"accommodation\" to light supply is evidenced by a modulation of the reactivity in relation to the schedule of light application under low fluence rates and the introduction of short darkness intervals during the first 30-s light pulse. The blue light-induced photostimulation is under phytochrome control.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"728-745"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabelle Kaiser, Annette B Pfahlberg, Maria Lehmann, Esther Buchta, Wolfgang Uter, Olaf Gefeller
{"title":"The extent of public awareness and use of the Global Solar UV Index as a worldwide health promotion instrument to improve sun protection: A systematic review and meta-analysis.","authors":"Isabelle Kaiser, Annette B Pfahlberg, Maria Lehmann, Esther Buchta, Wolfgang Uter, Olaf Gefeller","doi":"10.1111/php.14028","DOIUrl":"10.1111/php.14028","url":null,"abstract":"<p><p>Thirty years ago, the Global Solar UV Index (UVI) has been introduced as a health promotion instrument to improve sun protection. We assessed systematically global levels of awareness and use of the UVI as a prerequisite for the preventive effectiveness of this public health tool. We conducted a comprehensive literature search across 10 databases, including PubMed, Scopus and Web of Science Core Collection, as well as clinical trial registries and gray literature databases. The risk of bias of studies was evaluated using the Joanna Briggs Institute checklist for prevalence studies. In addition to narrative and descriptive analysis, we performed meta-analyses with geographical subgroup analyses to statistically summarize the results. In total, we identified 40 publications from 39 different studies across multiple global regions. However, the number of studies in the analyses varies depending on the outcome. The results, especially the awareness of the UVI, were largely dependent on the specific geographical location of the studies. While the prevalence of awareness of the UVI is high among Australian populations, there is considerable variability in levels of awareness across other global regions. At the same time, the use of the UVI is at a low level across all regions, demonstrating the need for enhanced dissemination of knowledge about the perils associated with ultraviolet radiation and the advantages of using the UVI.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"636-659"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes
{"title":"The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.","authors":"Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes","doi":"10.1111/php.14041","DOIUrl":"10.1111/php.14041","url":null,"abstract":"<p><p>Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm<sup>2</sup>) composed of 20 LED clusters, 2.14 mW/cm<sup>2</sup>/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm<sup>2</sup>) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"746-761"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}