Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes
{"title":"不同剂量的单波长和双波长全身光生物调制对肥胖小鼠代谢参数的影响","authors":"Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes","doi":"10.1111/php.14041","DOIUrl":null,"url":null,"abstract":"<p><p>Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm<sup>2</sup>) composed of 20 LED clusters, 2.14 mW/cm<sup>2</sup>/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm<sup>2</sup>) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.\",\"authors\":\"Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes\",\"doi\":\"10.1111/php.14041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. 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The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.
Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm2) composed of 20 LED clusters, 2.14 mW/cm2/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm2) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.
期刊介绍：
Photochemistry and Photobiology publishes original research articles and reviews on current topics in photoscience. Topics span from the primary interaction of light with molecules, cells, and tissue to the subsequent biological responses, representing disciplinary and interdisciplinary research in the fields of chemistry, physics, biology, and medicine. Photochemistry and Photobiology is the official journal of the American Society for Photobiology.
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