Enhancing bone remodeling and accelerating tooth movement with photobiomodulation in middle-aged adults.

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Selly S Suzuki, Amanda M Ribeiro, Marcella U R Fernandes, Chooryung Chung, Aguinaldo S Garcez
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Abstract

Although age is not a contraindication for orthodontic treatment, it can be considered more challenging in mature adult patients, mainly due to a less responsive bone metabolism and reduced osteoblastic activity compared to young patients. In orthodontics, photobiomodulation (PBM) has shown positive results in bone remodeling during tooth movement. This study seeks to assess the effect of PBM can have a positive effect on bone remodeling, stimulating bone formation in middle-aged individuals and allowing for a better periodontal condition. Bone structure and the length of the roots were evaluated using cone beam computed tomography images before and after tooth movement and PBM in patients aged between 40 and 60 years. In addition, we aimed to evaluate the expression of the markers receptor activator of NFκB (RANK), osteoprotegerin (OPG), and osteopontin (OPN) presented in the crevicular fluid using the enzyme-linked immunosorbent assay test. Tooth movement was performed by intruding upper molars with two mini-implants as anchorage bilaterally. One side received PBM with light-emitting diode (LED) light and the contralateral side was used as control (no irradiation). The PBM equipment specially designed for this study consisted of six LEDs of 5 mW each, for 7 minutes, totaling 2 J, 3 times a week, for 5 months. The PMB group showed greater tooth movement (p < 0.05), an increase of 74% on average for bone height. PBM induced a significant increase in RANK expression at month 3 (p < 0.05), and the expression of OPG and OPN showed a significant increase in the fifth month of movement (p < 0.05) in the PBM group. PBM may represent an adjunct therapeutic approach during tooth movement in more mature patients, leading to a more responsive bone metabolism and favoring more comprehensive orthodontic treatment.

光生物调节促进中年人骨重塑和加速牙齿运动。
虽然年龄不是正畸治疗的禁忌症,但对于成年患者来说,正畸治疗更具挑战性,主要是因为与年轻患者相比,成年患者的骨代谢反应较弱,成骨细胞活性降低。在正畸学中,光生物调节(PBM)在牙齿运动过程中的骨重塑中显示出积极的结果。本研究旨在评估PBM对骨重塑的积极影响,刺激中年个体的骨形成,并允许更好的牙周状况。年龄在40 ~ 60岁之间的患者在牙齿移动和PBM前后使用锥形束计算机断层扫描图像评估骨结构和根的长度。此外,我们旨在利用酶联免疫吸附试验评估骨桥蛋白(OPN)、骨保护素(OPG)和nf - κ b受体激活因子(RANK)在沟液中的表达。牙齿移动是通过侵入上磨牙,用两个微型种植体作为双侧固支。一侧用发光二极管(LED)照射PBM,对侧作为对照(无照射)。专门为本研究设计的PBM设备由6个5mw的led组成,每个5mw,持续7分钟,总计2 J,每周3次,持续5个月。PMB组牙齿运动明显增加(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Photochemistry and Photobiology
Photochemistry and Photobiology 生物-生化与分子生物学
CiteScore
6.70
自引率
12.10%
发文量
171
审稿时长
2.7 months
期刊介绍: Photochemistry and Photobiology publishes original research articles and reviews on current topics in photoscience. Topics span from the primary interaction of light with molecules, cells, and tissue to the subsequent biological responses, representing disciplinary and interdisciplinary research in the fields of chemistry, physics, biology, and medicine. Photochemistry and Photobiology is the official journal of the American Society for Photobiology.
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