Photochemistry and Photobiology最新文献_第6页

Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals. 短光信号诱导含羞草运动细胞的快速渗透收缩反应。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-29 DOI: 10.1111/php.14046

Gabriel Roblin, Christelle Moyen, Pierrette Fleurat-Lessard, Fabienne Dédaldéchamp

{"title":"Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals.","authors":"Gabriel Roblin, Christelle Moyen, Pierrette Fleurat-Lessard, Fabienne Dédaldéchamp","doi":"10.1111/php.14046","DOIUrl":"https://doi.org/10.1111/php.14046","url":null,"abstract":"The Mimosa pudica leaf has motor organs allowing movements driven by cell osmotic changes in the parenchyma cells in response to various stimuli. Short white light pulses induce rapid and large seismonastic-like movements (denoted \"photostimulation\") of the primary pulvini in various leaves within 120 s after the onset of light. An early event recorded is a wavelength-related modification of the plasma membrane difference: potential depolarization under white, blue, green, and red wavelengths, and hyperpolarization under far red wavelengths (and also in darkness). The photoreactivity of the pulvini is controlled by a circadian rhythm and modulated by the applied diurnal photoperiod cycle (photophase ranging from 6 to 18 h). The reactivity varied among plants and even between leaves on the same plant. The level of reactivity is related to the photon fluence rate in the range from 10 to 140 μmol m-2 s-1 under white light and to the experimental temperature in the range 15°C-35°C. An \"accommodation\" to light supply is evidenced by a modulation of the reactivity in relation to the schedule of light application under low fluence rates and the introduction of short darkness intervals during the first 30-s light pulse. The blue light-induced photostimulation is under phytochrome control.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemometric modeling of spectroscopic data for characterizing the visible-light-driven photocatalytic N-dealkylation of rhodamine B on a TiO₂ film. 建立光谱数据的化学计量模型，以描述可见光驱动的二氧化钛薄膜上罗丹明 B 的光催化 N-脱烷基反应。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-21 DOI: 10.1111/php.14043

Jesús M N Morales, Mirta R Alcaraz, Alba Loto, Eduardo A Parellada, Fiorella Tulli, Faustino E Morán Vieyra, Claudio D Borsarelli

{"title":"Chemometric modeling of spectroscopic data for characterizing the visible-light-driven photocatalytic N-dealkylation of rhodamine B on a TiO2 film.","authors":"Jesús M N Morales, Mirta R Alcaraz, Alba Loto, Eduardo A Parellada, Fiorella Tulli, Faustino E Morán Vieyra, Claudio D Borsarelli","doi":"10.1111/php.14043","DOIUrl":"https://doi.org/10.1111/php.14043","url":null,"abstract":"The green-light driven photocatalytic N-deethylation reaction of Rhodamine B (RhB) on a TiO2 film was investigated by UV-vis absorption and fluorescence emission spectroscopies, in addition to HPLC and HR-MS, to ascertain the nature of the reaction products. The evolution of the photocatalytic reaction was chemometrically analyzed using Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) of the spectroscopic data to obtain the kinetic and spectral decomposition of the RhB derivatives involved in the reaction. This was then compared with the results obtained by standard HPLC analysis. The MCR-ALS analysis yielded satisfactory spectral and kinetic profiles for RhB and the fully deethylated product, Rhodamine 110. However, the spectral profiles for the N-triethyl (3EtRh) and the mixture of the two isomeric N-diethyl (2EtRh) derivatives exhibited some spectral distortions due to significant spectral overlap between these compounds. In contrast to the HPLC analysis, the MCR-ALS could not resolve the N-ethylrhodamine (EtRh) derivative. The deethylation reactions occurred via independent zero-order steps at the surface of TiO2, indicating that the RhB degradation reaction is governed by the adsorption-desorption equilibrium of the dye and derivatives on the photocatalyst surface, thereby enhancing the diffusion of compounds on the surface.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bright and long-lasting aqueous peroxyoxalate chemiluminescence in cellulose microspheres. 纤维素微球中明亮持久的过氧化物水溶液化学发光。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-19 DOI: 10.1111/php.14040

Maidileyvis C Cabello, Erick L Bastos, Omar A A El Seoud, Wilhelm J Baader

引用次数: 0

The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice. 不同剂量的单波长和双波长全身光生物调制对肥胖小鼠代谢参数的影响

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-18 DOI: 10.1111/php.14041

Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes

{"title":"The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.","authors":"Maíra da Silva Almeida Rocha, Lucas Renan Sena de Oliveira, Diêgo Mendes Xavier, Natielle Cecília Dos Santos Ottone, Pedro Paulo Ribeiro Ferreira, Kaio Augusto Oliveira Paulino, Juliana Sales Rodrigues Costa, Graciene Fernandes Araújo Campos Fonseca, Gabriela Silva, Patrick Almeida Silva, Saulo Soares da Silva, João Paulo de Paula Almeida, Cândido Celso Coimbra, Elizabethe Adriana Esteves, Cleber Ferraresi, Flavio de Castro Magalhaes","doi":"10.1111/php.14041","DOIUrl":"https://doi.org/10.1111/php.14041","url":null,"abstract":"Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm2) composed of 20 LED clusters, 2.14 mW/cm2/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm2) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of chatbots in queries concerning fundamental concepts in photochemistry. 聊天机器人在光化学基本概念查询中的表现。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-04 DOI: 10.1111/php.14037

Masahiko Taniguchi, Jonathan S Lindsey

{"title":"Performance of chatbots in queries concerning fundamental concepts in photochemistry.","authors":"Masahiko Taniguchi, Jonathan S Lindsey","doi":"10.1111/php.14037","DOIUrl":"https://doi.org/10.1111/php.14037","url":null,"abstract":"The advent of chatbots raises the possibility of a paradigm shift across society including the most technical of fields with regard to access to information, generation of knowledge, and dissemination of education and training. Photochemistry is a scientific endeavor with roots in chemistry and physics and branches that encompass diverse disciplines ranging from astronomy to zoology. Here, five chatbots have each been challenged with 13 photochemically relevant queries. The chatbots included ChatGPT 3.5, ChatGPT 4.0, Copilot, Gemini Advanced, and Meta AI. The queries encompassed fundamental concepts (e.g., \"Why is the fluorescence spectrum typically the mirror image of the absorption spectrum?\"), practical matters (e.g., \"What is the inner filter effect and how to avoid it?\"), philosophical matters (\"Please create the most important photochemistry questions.\"), and specific molecular features (e.g., \"Why are azo dyes non-fluorescent?\"). The chatbots were moderately effective in answering queries concerning fundamental concepts in photochemistry but were glaringly deficient in specialized queries for dyes and fluorophores. In some instances, a correct response was embedded in verbose scientific nonsense whereas in others the entire response, while grammatically correct, was utterly meaningless. The unreliable accuracy makes present chatbots poorly suited for unaided educational purposes and highlights the importance of domain experts.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The acid sphingomyelinase inhibitor imipramine enhances the release of UV photoproduct-containing DNA in small extracellular vesicles in UVB-irradiated human skin. 酸性鞘磷脂酶抑制剂亚胺培南能增强紫外线照射下人体皮肤细胞外小泡中含有紫外线光电导体的DNA的释放。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-03 DOI: 10.1111/php.13932

M Alexandra Carpenter, Anita Thyagarajan, Madison Owens, Risha Annamraju, Christina B Borchers, Jeffrey B Travers, Michael G Kemp

{"title":"The acid sphingomyelinase inhibitor imipramine enhances the release of UV photoproduct-containing DNA in small extracellular vesicles in UVB-irradiated human skin.","authors":"M Alexandra Carpenter, Anita Thyagarajan, Madison Owens, Risha Annamraju, Christina B Borchers, Jeffrey B Travers, Michael G Kemp","doi":"10.1111/php.13932","DOIUrl":"10.1111/php.13932","url":null,"abstract":"Nucleic acids, lipids, and other cell components can be found within different types of extracellular vesicles (EVs), which include apoptotic bodies (ABs), large extracellular vesicles (LEVs), and small extracellular vesicles (SEVs). Release of LEVs from cells can be reduced by genetic or pharmacological inhibition of the enzyme acid sphinogomyelinase (aSMase), and indeed several studies have demonstrated a role for the clinically approved aSMase inhibitor imipramine in blocking LEV release, including in response to UVB exposure. Given that exposure of keratinocytes to UVB radiation results in the generation of UVR photoproducts in DNA that can subsequently be found in association with ABs and SEVs, we examined how imipramine impacts the release of extracellular DNA containing UVR photoproducts at an early time point after UVR exposure. Using several different model systems, including cultured keratinocytes in vitro, discarded human surgical skin ex vivo, and skin biopsies obtained from treated human subjects, these pilot studies suggest that imipramine treatment stimulates the release of CPD-containing, SEV-associated DNA. These surprising findings indicate that LEV and SEV generation pathways could be linked in UVB-irradiated cells and that imipramine may exacerbate the systemic effects of extracellular UVR-damaged DNA throughout the body.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1894-1901"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The REV-ERB antagonist SR8278 modulates keratinocyte viability in response to UVA and UVB radiation. REV-ERB 拮抗剂 SR8278 可调节角质细胞对 UVA 和 UVB 辐射的活力。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-08 DOI: 10.1111/php.13930

William Cvammen, Michael G Kemp

{"title":"The REV-ERB antagonist SR8278 modulates keratinocyte viability in response to UVA and UVB radiation.","authors":"William Cvammen, Michael G Kemp","doi":"10.1111/php.13930","DOIUrl":"10.1111/php.13930","url":null,"abstract":"The nucleotide excision repair (NER) system removes UV photoproducts from genomic DNA and is controlled by the circadian clock. Given that small-molecule compounds have been developed to target various clock proteins, we examined whether the cryptochrome inhibitor KS15 and REV-ERB antagonist SR8278 could modulate keratinocyte responses to UV radiation in vitro. We observed that though SR8278 promoted cell viability in UVB-irradiated cells, it had little effect on NER or on the expression of the clock-regulated NER factor XPA. Rather, we found that both KS15 and SR8278 absorb light within the UV spectrum to limit initial UV photoproduct formation in DNA. Moreover, SR8278 promoted UVB viability even in cells in which the core circadian clock protein BMAL1 was disrupted, which indicates that SR8278 is likely acting via other REV-ERB transcriptional targets. We further observed that SR8278 sensitized keratinocytes to light sources containing primarily UVA wavelengths of light likely due to the generation of toxic reactive oxygen species. Though other studies have demonstrated beneficial effects of SR8278 in other model systems, our results here suggest that SR8278 has limited utility for UV photoprotection in the skin and will likely cause phototoxicity in humans or mammals exposed to solar radiation.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1864-1873"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy: Critical PDT theory IX-Translational efforts. 光动力疗法：关键PDT理论IX转化努力。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2023-10-09 DOI: 10.1111/php.13867

David Kessel

引用次数: 0

Potential of using medicinal plant extracts as photosensitizers for antimicrobial photodynamic therapy. 将药用植物提取物作为光敏剂用于抗菌光动力疗法的潜力。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-08 DOI: 10.1111/php.13935

Aliaksandr V Mikulich, Vitaly Yu Plavskii, Antonina I Tretyakova, Raman K Nahorny, Andrey N Sobchuk, Natalia V Dudchik, Olga A Emeliyanova, Anastasia I Zhabrouskaya, Ludmila G Plavskaya, Tatsiana S Ananich, Olga N Dudinova, Ihar A Leusenka, Sergey V Yakimchuk, Alexei D Svechko, Tran Quoc Tien, Quang Cong Tong, Thanh Phuong Nguyen

{"title":"Potential of using medicinal plant extracts as photosensitizers for antimicrobial photodynamic therapy.","authors":"Aliaksandr V Mikulich, Vitaly Yu Plavskii, Antonina I Tretyakova, Raman K Nahorny, Andrey N Sobchuk, Natalia V Dudchik, Olga A Emeliyanova, Anastasia I Zhabrouskaya, Ludmila G Plavskaya, Tatsiana S Ananich, Olga N Dudinova, Ihar A Leusenka, Sergey V Yakimchuk, Alexei D Svechko, Tran Quoc Tien, Quang Cong Tong, Thanh Phuong Nguyen","doi":"10.1111/php.13935","DOIUrl":"10.1111/php.13935","url":null,"abstract":"Antimicrobial photodynamic therapy (APDT) is a promising approach to overcome antimicrobial resistance. However, for widespread implementation of this approach, approved photosensitizers are needed. In this study, we used commercially available preparations (Calendulae officinalis floridis extract, Chamomillae recutitae floridis extract, Achillea millefolii herbae extract; Hypericum perforatum extract; Eucalyptus viminalis folia extract) as photosensitizers for inactivation of gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria. Spectral-luminescent analysis has shown that the major chromophores are of chlorophyll (mainly chlorophyll a and b) and hypericin nature. The extracts are efficient generators of singlet oxygen with quantum yield (γΔ) from 0.40 to 0.64 (reference compound, methylene blue with γΔ = 0.52). In APDT assays, bacteria before irradiation were incubated with extracts for 30 min. After irradiation and 24 h of incubation, colony-forming units (CFU) were counted. Upon exposure of P. aeruginosa to radiation of 405 nm, 590 nm, and 660 nm at equal energy dose of 30 J/cm2 (irradiance - 100 mW/cm2, exposure time - 5 min), the most pronounced effect is observed with blue light (>3 log10 reduction); in case of S. aureus, the effect is approximately equivalent for light of indicated wavelengths and dose (>4 log10 reduction).","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1833-1847"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of lapatinib for enhancing 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy in human cancer cell lines with varied ABCG2 activities. 拉帕替尼在具有不同 ABCG2 活性的人类癌细胞系中增强 5-氨基乙酰丙酸介导的原卟啉 IX 荧光和光动力疗法的效果。

IF 4.6 4区生物学

Photochemistry and Photobiology Pub Date : 2024-11-01 Epub Date: 2024-03-13 DOI: 10.1111/php.13936

Richard Howley, Jordyn Olsen, Bin Chen

{"title":"Effectiveness of lapatinib for enhancing 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy in human cancer cell lines with varied ABCG2 activities.","authors":"Richard Howley, Jordyn Olsen, Bin Chen","doi":"10.1111/php.13936","DOIUrl":"10.1111/php.13936","url":null,"abstract":"5-Aminolevulinic acid (ALA) is a prodrug for protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) and fluorescence-guided tumor surgery. We previously reported that lapatinib, a repurposed ABCG2 inhibitor, enhanced ALA-induced PpIX fluorescence and PDT by blocking ABCG2-mediated PpIX efflux. In the present study, we evaluated how the variation in ABCG2 activities/protein levels affected tumor cell response to the enhancement of PpIX/PDT by lapatinib and Ko143, an ABCG2 tool inhibitor. ABCG2 activities and protein levels were determined in a panel of human cancer cell lines. Effects of lapatinib and Ko143 on enhancing ALA-PpIX fluorescence and PDT were evaluated and correlated with tumor cell ABCG2 activities. We found that both lapatinib and Ko143 enhanced ALA-PpIX fluorescence and PDT in a dose-dependent manner, although lapatinib exhibited lower efficacy and potency than Ko143 in nearly all cancer cell lines. The EC50 of ABCG2 inhibitors for enhancing ALA-PpIX and PDT had a positive correlation with tumor cell ABCG2 activities, indicating that tumor cell lines with lower ABCG2 activities were more sensitive to ABCG2 inhibitors for PpIX/PDT enhancement. Our results suggest that, for optimal therapeutic enhancement, the dose of ABCG2 inhibitors needs to be tailored based on the ABCG2 expression/activity in tumors.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1579-1589"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0