Photochemistry and Photobiology最新文献_第5页

An anthracene-based symmetrical azine linkage turn-on fluorogenic probe for selective and specific detection of sarin simulant, diethylchlorophosphate. 一种基于蒽基对称嘧啶键的荧光探针，用于选择性和特异性检测沙林模拟物二乙基氯磷酸。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-06-12 DOI: 10.1111/php.70004

Anupama Rani Das, Sabbir Ahamed, Jyoti Chourasia, Subekchha Pradhan, Najmin Tohora, Upika Darnal, Shraddha Rai, Shubham Lama, Sudhir Kumar Das

{"title":"An anthracene-based symmetrical azine linkage turn-on fluorogenic probe for selective and specific detection of sarin simulant, diethylchlorophosphate.","authors":"Anupama Rani Das, Sabbir Ahamed, Jyoti Chourasia, Subekchha Pradhan, Najmin Tohora, Upika Darnal, Shraddha Rai, Shubham Lama, Sudhir Kumar Das","doi":"10.1111/php.70004","DOIUrl":"10.1111/php.70004","url":null,"abstract":"Notably, the G-series nerve agents possess extreme toxicity and can be synthesized through a facile protocol; their abuse becomes a significant threat to the environment and human life. Hence, it is emerging to develop an efficient chemosensor for the selective identification of these nerve agents. In this report, we have presented an azine-based symmetrical fluorogenic probe, BAH, for the selective detection of sarin gas, one of the fatal G-series nerve agent surrogates, diethylchlorophosphate (DCP). BAH is non-fluorescent, but the progressive accumulation of DCP displays a naked-eye bright greenish cyan fluorometric change under a 365 UV lamp. Recognizable greenish cyan color fluorescence diminished completely for the accumulation of triethylamine (TEA), confirming its reusability multiple times. A paper strips-based test kit experiment has also been demonstrated for the onsite detection of these nerve agents, especially in remote areas in solution and vapor phases, respectively. A superior application combining the attractiveness and efficiency of BAH in the gaseous phase was also demonstrated. The BAH-based fluorogenic sensor shows excellent selectivity towards DCP with a detection and quantification limit in the μM range. The simple, rapid detection makes our probe unique and has significant utility for the recognition of DCP in real threat scenarios.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"446-456"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review. 利用蓝光光生物调节治疗癌症：来自系统综述的证据。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-08-28 DOI: 10.1111/php.70025

Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues

{"title":"Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review.","authors":"Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues","doi":"10.1111/php.70025","DOIUrl":"10.1111/php.70025","url":null,"abstract":"Cancer is a chronic disease responsible for millions of deaths annually. Its multifaceted profile, with diverse types and anatomical locations, complicates treatment, often limited to surgery, radiotherapy, and chemotherapy. These treatments are frequently associated with increased tumor aggressiveness and recurrence, highlighting the urgent need for new, less invasive therapies. Recent studies suggest that blue light (BL; 450-470 nm) may offer anti-tumor and pro-apoptotic effects, making it a promising alternative for cancer treatment. However, its cellular and molecular mechanisms remain unclear. This qualitative systematic review, conducted in accordance with PRISMA guidelines, analyzed 37 in vitro and in vivo studies published between 2002 and 2024, retrieved from databases including MEDLINE/PubMed, EMBASE, and LILACS, with a focus on the effects of photobiomodulation (PBM) with blue light (450-470 nm) in pre-clinical cancer models. BL demonstrated anti-tumor potential by reducing cell viability, proliferation, migration, and invasion, as well as increasing ROS production and inducing apoptosis. In animal models, BL also inhibited tumor growth, metastasis, and improved survival. Despite the encouraging findings, considerable methodological heterogeneity and insufficient reporting of dosimetric parameters compromise the reproducibility and comparability of results across studies. These findings underscore the therapeutic potential of BL in oncology and highlight the need for standardized protocols to support clinical translation.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"370-399"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoengineered photosensitizers for photodynamic priming to overcome P-glycoprotein-mediated multidrug resistance. 纳米工程光敏剂光动力启动克服p糖蛋白介导的多药耐药。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-11-14 DOI: 10.1111/php.70049

Idrisa Rahman, Anju Meda, Kaitlyn A Moore, Payal Srivastava, Anika Dasgupta, Andaleeb Sajid, Suresh V Ambudkar, Huang-Chiao Huang

{"title":"Nanoengineered photosensitizers for photodynamic priming to overcome P-glycoprotein-mediated multidrug resistance.","authors":"Idrisa Rahman, Anju Meda, Kaitlyn A Moore, Payal Srivastava, Anika Dasgupta, Andaleeb Sajid, Suresh V Ambudkar, Huang-Chiao Huang","doi":"10.1111/php.70049","DOIUrl":"10.1111/php.70049","url":null,"abstract":"P-glycoprotein (P-gp, ABCB1)-mediated multidrug resistance (MDR) remains a significant barrier to successful chemotherapy outcomes for cancer patients. While photoactivation of verteporfin (VP), a photosensitizer, has demonstrated success for overcoming MDR through direct protein aggregation upon photoactivation and through adenosine triphosphate (ATP) depletion, the impact of VP's formulation on P-gp function and cellular energetics has not been fully characterized in this context. In this study, we screened four well-established VP formulations-liposomal VP (L-VP), lysophosphatidylcholine-conjugated VP (lysoPC VP), liposomal formulation of lysoPC VP (L-lysoPC VP), and a self-assembled VP nanoaggregate (NanoVP), with a free form of VP as a control-for their ability to inhibit P-gp. Using a combination of in vitro intracellular VP accumulation assays, P-gp substrate retention experiments, and Seahorse-based metabolic profiling, we identified NanoVP as the lead formulation for P-gp modulation in cancer cells. NanoVP effectively depleted ATP in drug-resistant cancer cells, while being recognized as a P-gp substrate. Photodynamic priming with NanoVP at sub-cytotoxic light doses enhanced P-gp substrate retention within the cells without damaging P-gp protein, indicating ATP depletion as the primary mode of functional inhibition. These findings highlighted NanoVP's clinical potential to enhance chemotherapeutic efficacy via photoactivation-based modulation of P-gp's function in multidrug-resistant cancers.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"328-350"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern: A.H. Nejat, M. Eshghpour, N. Danaeifar, M. Abrishami, F. Vahdatinia, and R. Fekrazad, "Effect of Photobiomodulation on The Incidence Of Alveolar Osteitis And Postoperative Pain Following Mandibular Third Molar Surgery: A Double-Blind Randomized Clinical Trial," Photochemistry and Photobiology, 97 no. 5 (2021): 1129-1135. https://doi.org/10.1111/php.13457. 关注表达：A. h . Nejat， M. Eshghpour， N. Danaeifar， M. Abrishami， F. Vahdatinia， R. Fekrazad，“光生物调节对下颌第三磨牙手术后牙槽骨炎和术后疼痛的影响：一项双盲随机临床试验”，光化学与光生物学，1997年第7期。5(2021): 1129-1135。https://doi.org/10.1111/php.13457。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-02-26 DOI: 10.1111/php.70086

引用次数: 0

Evaluating tools for predicting and measuring radiometric performance of germicidal ultraviolet systems. 预测和测量杀菌紫外系统辐射性能的评估工具。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-02-18 DOI: 10.1111/php.70080

Valeria Holland, Belal Abboushi, Eduardo Rodriguez-Feo Bermudez, Jason Tuenge, Annabelle Johnson, Shohoria Shorno, Ernest R Blatchley, Gabe Arnold

{"title":"Evaluating tools for predicting and measuring radiometric performance of germicidal ultraviolet systems.","authors":"Valeria Holland, Belal Abboushi, Eduardo Rodriguez-Feo Bermudez, Jason Tuenge, Annabelle Johnson, Shohoria Shorno, Ernest R Blatchley, Gabe Arnold","doi":"10.1111/php.70080","DOIUrl":"https://doi.org/10.1111/php.70080","url":null,"abstract":"Germicidal ultraviolet (GUV) air treatment technologies can be effective and safe for reducing airborne disease transmission. Today, GUV systems are designed and evaluated using simulation and measurement tools that require further assessment of their accuracy in estimating fluence rate and irradiance. This article reports results from two experiments where two simulation software (Visual Lighting and Photopia) and two measurement techniques (tetrahedron and cubic approximations) were evaluated against chemical actinometry for quantification of GUV fluence rate in a chamber. Additionally, Visual and Photopia were compared to measurements of planar UV-C irradiance for eye and skin exposure. Results showed that overall mean fluence rates were similar between actinometry and both simulation software for WR GUV systems as well as between actinometry and Photopia for UR GUV systems. The tetrahedron approximation better predicted overall mean fluence rate for WR and UR GUV systems, compared to a cubic approximation which tended to overestimate it. Compared to measurements, simulated eye and skin irradiance varied, with higher variability in simulated eye irradiance. The evaluated simulation software can be used to guide the design of GUV systems but must be supplemented with in situ measurements.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation. RAD51和RAD51平行抑制使非复制的静止角质形成细胞对紫外线辐射敏感。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-02-11 DOI: 10.1111/php.70079

Saman Khan, Angitha Nair, M Alexandra Carpenter, Michael G Kemp

{"title":"RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation.","authors":"Saman Khan, Angitha Nair, M Alexandra Carpenter, Michael G Kemp","doi":"10.1111/php.70079","DOIUrl":"10.1111/php.70079","url":null,"abstract":"UV radiation (UVR) leads to the formation of potentially lethal and chromosome-destabilizing double-strand breaks (DSBs) in DNA. However, most studies on UVR-induced DSB formation and repair have used cells that are actively progressing throughout the cell cycle. To explore how nonreplicating, quiescent cells deal with UVR-induced DSBs, we used small-molecule inhibitors of various DSB repair pathways and unexpectedly observed a major role for the recombination protein RAD51 in promoting quiescent HaCaT keratinocyte survival. We further observed that both DSB formation and RAD51 function occur independently of nucleotide excision repair, which generates potentially unstable single-stranded DNA gaps. However, RAD51 inhibition also sensitizes quiescent cells to agents that are known to inhibit transcription, thus suggesting a role for transcription in UVR-induced DSB formation. Interestingly, siRNA-mediated knockdown of RAD51 did not sensitize cells to UVR to the same extent as pharmacological inhibition did. In contrast, knockdown of several Rad51 paralogs negatively impacted cell viability after UVR exposure, similar to pharmacological inhibition, suggesting that pharmacological inhibitors of RAD51 may also target one or more RAD51 paralogs. In summary, these findings highlight the important roles of RAD51 and its paralogs in promoting quiescent cell survival in response to UVR.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating photodynamic therapy response in head and neck cancer with EGFR-targeted paired-agent imaging. 用egfr靶向配对显像评价头颈癌的光动力治疗反应。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-02-06 DOI: 10.1111/php.70076

Reeham Choudhury, Sanjana Pannem, Yichen Feng, Sassan Hodge, Kimberley S Samkoe

{"title":"Evaluating photodynamic therapy response in head and neck cancer with EGFR-targeted paired-agent imaging.","authors":"Reeham Choudhury, Sanjana Pannem, Yichen Feng, Sassan Hodge, Kimberley S Samkoe","doi":"10.1111/php.70076","DOIUrl":"https://doi.org/10.1111/php.70076","url":null,"abstract":"Head and neck cancer (HNC) affects thousands globally, with high morbidity rates due to standard treatments like surgery and radiation. Photodynamic therapy (PDT) has shown great promise as a less destructive alternative, selectively targeting tumors while preserving healthy tissue. However, assessing treatment response in the days after PDT is challenging due to significant inflammation and the subsequent vascular shutdown of the tumor. We hypothesize that fluorescence paired-agent imaging (PAI) can provide early molecular insights within 24 h of PDT to evaluate treatment efficacy. PAI utilizes two fluorescent agents to correct for perfusion-related changes, allowing for accurate quantification of key signaling proteins. Specifically, we tracked epidermal growth factor receptor (EGFR) response to benzoporphyrin derivative monoacid (BPD)-PDT at 690 nm, with light fluences ranging from 0 to 100 J/cm2. Twenty-four hours post-PDT, EGFR concentrations were measured using PAI with ABY-029 and IRDye 680LT as targeted and untargeted agents, respectively. These findings were compared to histopathology (H&E and EGFR IHC). Our histological results demonstrated that EGFR expression increased with low PDT doses (10 and 25 J/cm2) and decreased below baseline expression with higher doses (50 and 100 J/cm2). Fluorescence intensity of both ABY-029 and IRDye 680LT was highly variable with treatment dose and was not correlative to tumor response. In contrast, the PAI-binding potential (BP) corresponded to the varying EGFR expression measured by pathology. In vivo and ex vivo PAI BP was moderately to highly correlative to percent area IHC EGFR expression (r = 0.65 and 0.54, p < 0.05, respectively) and the in vivo 100 J/cm2 treatment group demonstrated significantly lower BP than the controls. PAI emerges as a promising tool for tracking early molecular changes in HNC, with potential clinical applications.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-emitting diode photobiomodulation on rheumatoid arthritis and osteoarthritis: In vitro and in vivo studies. 发光二极管对类风湿关节炎和骨关节炎的光生物调节：体外和体内研究。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-02-02 DOI: 10.1111/php.70077

Adenilson de Souza da Fonseca, Flávia de Paoli

{"title":"Light-emitting diode photobiomodulation on rheumatoid arthritis and osteoarthritis: In vitro and in vivo studies.","authors":"Adenilson de Souza da Fonseca, Flávia de Paoli","doi":"10.1111/php.70077","DOIUrl":"https://doi.org/10.1111/php.70077","url":null,"abstract":"Light-emitting diodes (LEDs) are light sources that can be used for photobiomodulation to treat various diseases and clinical conditions. Growing evidence suggests that photobiomodulation is a promising treatment for rheumatoid arthritis (RA) and osteoarthritis (OA) because of its analgesic and anti-inflammatory effects. However, such evidence is primarily based on studies evaluating low-power laser-based photobiomodulation, and few studies have assessed the efficacy of LED photobiomodulation in the treatment of RA and OA. Thus, this study aimed to review studies on LED photobiomodulation for the treatment of RA and OA, summarizing the irradiation parameters and conditions, and reporting the study types and main results. Studies on the effects of LED photobiomodulation on RA and OA were accessed via PubMed. Data from accessed studies show that LED photobiomodulation has been carried out with red and infrared LEDs based on in vitro and in vivo experimental models. This therapy may decrease arthritic markers, including edema, hyperalgesia, inflammation, cartilage degradation, extracellular matrix alterations, and proinflammatory cytokine levels. LED photobiomodulation could be as effective a therapy as laser photobiomodulation, but further clinical studies are necessary to verify its therapeutic benefits in both RA and OA.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of solar-simulated (UVB plus UVA) radiation on the skin microbiome: An exploratory study. 太阳模拟（UVB + UVA）辐射对皮肤微生物组的影响：一项探索性研究。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-01-29 DOI: 10.1111/php.70078

Florian Dimmers, Doreen Reichert, Claudia Wigmann, Carles Trullàs, Jaime Piquero-Casals, Anthony Brown, Monica Foyaca, Charlotte Esser, Jean Krutmann

{"title":"Effects of solar-simulated (UVB plus UVA) radiation on the skin microbiome: An exploratory study.","authors":"Florian Dimmers, Doreen Reichert, Claudia Wigmann, Carles Trullàs, Jaime Piquero-Casals, Anthony Brown, Monica Foyaca, Charlotte Esser, Jean Krutmann","doi":"10.1111/php.70078","DOIUrl":"https://doi.org/10.1111/php.70078","url":null,"abstract":"This exploratory in vivo study investigated the impact of solar-simulated ultraviolet (UV) radiation (UVB plus UVA) on the composition of the human skin microbiome in healthy male volunteers. Thirty Caucasian men were exposed to suberythemal and erythemal doses of UV radiation (0.5, 0.7, and 1.0 minimal erythema dose, MED) on defined areas of the lower back. Skin swabs were collected from both irradiated (n = 243) and nonirradiated control sites (n = 81) 30 min, 24 h, and 96 h postexposure. The microbial profiles were generated using flow cytometry, and the data were analyzed via the open-access bioinformatic platform FlowSoFine™. The results revealed pronounced alterations in the microbial composition, with changes already detectable 30 min after exposure. Although partial recovery was observed over time, certain microbial shifts persisted. Further analysis indicated dose-dependent trends in microbiome changes, suggesting a potential relationship between the extent of microbial alteration and the applied UV dose. These results suggest that even low, nonerythematous exposure to solar-simulated UV radiation can rapidly alter the microbial balance of the skin and emphasize the role of UV radiation as a potent modulator of the skin microbial homeostasis.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilized CuCl₂/TiO₂ photocatalysts for the selective oxidation of benzyl alcohol to benzaldehyde. 固定化CuCl2/TiO2光催化剂在苯甲醇选择性氧化制苯甲醛中的应用。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-01-27 DOI: 10.1111/php.70072

Nosaibeh Nosrati-Ghods, Lidija Čuček, Hamidreza Moradi, Eric van Steen

{"title":"Immobilized CuCl2/TiO2 photocatalysts for the selective oxidation of benzyl alcohol to benzaldehyde.","authors":"Nosaibeh Nosrati-Ghods, Lidija Čuček, Hamidreza Moradi, Eric van Steen","doi":"10.1111/php.70072","DOIUrl":"https://doi.org/10.1111/php.70072","url":null,"abstract":"The oxidation of alcohols to aldehydes is a key transformation in industrial chemistry, as aldehydes are vital intermediates in the synthesis of pharmaceuticals and fine chemicals. Conventional oxidation routes typically employ stoichiometric and corrosive oxidants, generating significant environmental concerns. Greener oxidants such as molecular oxygen (O2) offer a more sustainable alternative to stoichiometric oxidants; however, their efficient utilization requires activation by catalysts (e.g., Cu-, Pd-, Au-, or Ti-based systems). Homogeneous photocatalysts such as CuCl2 exhibit promising activity under light irradiation but are limited by challenges in separation and recycling. This study investigates the immobilization of CuCl2 and TiO2 (P25) within sodium alginate beads to facilitate photocatalyst recovery and minimize metal leaching. Under UV irradiation for 4 h, benzyl alcohol conversions of 54% (P25) and 49% (CuCl2) were achieved. Catalyst encapsulation markedly reduced activity due to internal mass transport limitations, as restricted diffusion of O2 and benzyl alcohol within the bead matrix limited access to active sites and suppressed overall reaction rates. Co-immobilization of P25 and CuCl2 partially restored conversion (22%), while maintaining high benzaldehyde selectivity (≈1 after 4 h) across all systems. These findings highlight oxygen depletion and mass transfer resistance as key constraints in bead-based photocatalysts. To guide further optimization, a MATLAB-based reactor model incorporating species transport, interfacial mass transfer, and kinetics was developed.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146066013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0