Photochemistry and Photobiology最新文献

{"title":"Engineering a photoswitchable acaricidal agent by the integration of an azobenzene moiety with a bifenazate structure.","authors":"Yongchao Zhang, Zhi Qiao, Zimai Liu, Qi Yin, Xiaoyan Li, Zhong Li, Wen Fu, Xusheng Shao","doi":"10.1111/php.70074","DOIUrl":"10.1111/php.70074","url":null,"abstract":"<p><p>Photopharmacology achieves precise photo controlled regulation of drug activity by utilizing the properties of photochromic ligands. In this study, a series of novel azobenzene-based photochromic ligands (ABB1-5) were designed and synthesized, and their biological activities were confirmed to be precisely regulated by light irradiation. Bioassays against larvae of Culex pipiens pallens showed that the activity of ABB1 was significantly enhanced after light exposure, with the median lethal concentration (LC₅₀) decreasing from 27.20 μg/mL before irradiation to 16.99 μg/mL after, a reduction of 10.21 μg/mL, yielding a difference coefficient of 1.60. Similarly, experiments on Tetranychus cinnabarinus demonstrated a remarkable decrease in acaricidal activity for ABB4 after irradiation, as evidenced by an increase in LC₅₀ from 7.01 to 18.40 μg/mL, an increase of 11.39 μg/mL, with a difference coefficient of 2.62. Notably, the light-induced differences in activity exhibited by the ABBs series against both C. pipiens pallens larvae and T. cinnabarinus not only validate the potential of photochromic ligands in the precise optical control of drug efficacy but also offer a novel strategy for delaying the development of resistance to acaricides in phytophagous mites.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1195-1209"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early oxidation-related changes in aqueous humor following eye exposure to ultraviolet-A radiation.","authors":"Corinne Zinflou, Patrick J Rochette","doi":"10.1111/php.70146","DOIUrl":"https://doi.org/10.1111/php.70146","url":null,"abstract":"<p><p>Ultraviolet (UV) A represents 95% of the UV rays reaching the ocular surface. These rays exert their toxicity mainly via photosensitization reactions that generate oxidation and are implicated in various pathologies of the anterior segment of the eye. The cornea absorbs some UVA rays, but the majority passes through the aqueous humor (AH) to reach the lens. Previous work has mainly focused on understanding the consequences of UVA exposure on the cornea and lens, but the AH has been largely ignored. AH contains a high concentration of antioxidants and thus represents a key line of defense against oxidative stress in the anterior part of the eye. Using cadaveric rabbit eyes, we have evaluated the influence of ocular UVA exposure on oxidation in AH. Ocular exposure to UVA mediates the reduction of ascorbic acid levels in AH and results in a marked decrease in the reduced to oxidized glutathione (GSH/GSSG) ratio in AH, an increase in S-glutathionylated proteins (PSSG) content, and in the accumulation of toxic diffusible products such as malondialdehyde, a toxic by-product resulting from lipid peroxidation. These generated products can threaten the integrity of the trabecular meshwork during AH outflow or of structures in contact with AH such as the corneal endothelium or the lens. This work represents the first evidence that the toxicity of UVA to the eye can be mediated by its effect on AH. A better understanding of the effects induced by UVA on AH redox homeostasis is important if we want to better understand the risks associated with ocular UVA exposure.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratinocytes exposed to ultraviolet A and ultraviolet B radiation induce responses in melanocytes.","authors":"Lais Zortéa, Andressa Mai Matsumoto, Alessandra Costa Lopes, Eduardo Felipe Wagner, Tanira da Silveira Prieto, Andrés Delgado Cañedo, Daza de Moraes Vaz Batista Filgueira, Ana Paula de Souza Votto","doi":"10.1111/php.70143","DOIUrl":"https://doi.org/10.1111/php.70143","url":null,"abstract":"<p><p>Ultraviolet (UV) radiation exerts a strong influence on skin homeostasis and directly affects communication between keratinocytes and melanocytes. This study investigated how exposure of keratinocytes to UVA and UVB radiation alters cellular signaling with melanocytes using conditioned medium, that is, culture medium collected from keratinocytes after irradiation, to evaluate its effects on mitochondrial activity, proliferation, viability, and cell cycle progression of melanocytes. Keratinocytes were irradiated with UVA (4 J.cm^-2) or UVB (20 mJ.cm^-2), and the conditioned medium was collected 24 h after irradiation. Subsequently, irradiated or non-irradiated melanocytes were treated with the medium. The results showed that the conditioned medium from keratinocytes, especially those exposed to UVA radiation, significantly increased mitochondrial activity and melanocyte proliferation. Although direct UVA exposure reduced melanocyte viability, treatment with conditioned medium promoted cellular recovery over time. The conditioned medium obtained from UVB-irradiated keratinocytes also stimulated proliferation, although to a lesser extent than the medium from non-irradiated keratinocytes. Additionally, it was observed that the conditioned medium from UVA-irradiated keratinocytes induced cell cycle progression, increasing the proportion of melanocytes in the S and G2/M phases. These findings indicate that soluble factors secreted by irradiated keratinocytes play an important role in modulating the functional responses of melanocytes, potentially contributing to adaptive mechanisms related to UV radiation exposure.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A low-cost handheld device for monitoring cutaneous photosensitivity.","authors":"Md Asaduzzaman Rasel, Ryan Beland, Shakir Khan, Tayyaba Hasan, Jonathan P Celli","doi":"10.1111/php.70140","DOIUrl":"10.1111/php.70140","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) has been shown to be clinically effective for multiple cancers with low side effects and minimal off-target toxicity in comparison to traditional anticancer drugs. One of the only widely noted safety considerations for PDT is the potential for residual cutaneous photosensitivity after treatment, especially for protocols where the photosensitizer is administered systemically. The need to monitor cutaneous photosensitivity is particularly important for the implementation of PDT in resource-limited settings where overnight hospitalization is not available. Here, we report a compact, low-cost, cutaneous photosensitivity detection (CPD) device enabling real-time, contact-based fluorescence quantification that can be used as a home health solution for assessing cutaneous phototoxicity risk. The prototype device uses a 405 nm excitation LED, a long-pass emission filter (> 600 nm), and a photodiode to measure protoporphyrin IX (PpIX) fluorescence. Validation in tissue-mimicking phantoms, TR146 oral squamous carcinoma cell models, and murine in vivo studies demonstrates sensitivity within the clinically relevant submicromolar regime (R² > 0.9), accurate capture of aminolaevulinic acid-induced PpIX kinetics, and strong concordance with fluorescence spectroscopy measurements and imaging using a commercial in vivo imaging system. To model the effect of epidermal melanin, we also measure the fluorescence signal as a function of phantom pigmentation using coffee. To further investigate the role of epidermal melanin in attenuating blue excitation light used by this hardware, we ran a series of Monte Carlo simulations modeling light propagation in skin with varying percent melanin corresponding to a range of Fitzpatrick skin types. This study sets the stage for clinical validation of the CPD device as a tool for personalized photoprotection and data-driven discharge decisions following PDT, with relevance for point-of-care and resource-limited settings.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluence rate and ozone production from far-UVC lamps - A perspective.","authors":"Holger Claus","doi":"10.1111/php.70139","DOIUrl":"https://doi.org/10.1111/php.70139","url":null,"abstract":"<p><p>Filtered Far UV-C lamps (≈222 nm) are increasingly proposed for continuous air and surface disinfection in occupied spaces. Their performance is governed by the fluence rate within the room, which determines both airborne pathogen inactivation and photochemical by-product formation, particularly ozone. However, fluence rate is frequently confused with irradiance, inconsistently measured, and rarely linked quantitatively to ozone production. This prospective clarifies the radiometric foundations of fluence rate, distinguishes it from irradiance, and discusses the implications for modeling, measurement, and interpretation of Far-UVC installations. Methods for calculating room fluence rate distributions are reviewed, together with the limitations of practical measurement techniques. Photolytic ozone generation at 222 nm is examined using established atmospheric chemistry, and the concept of a normalized ozone formation coefficient is introduced to relate room-average fluence rate to ozone production. A steady-state indoor ozone model incorporating surface losses, ventilation, and occupant effects is summarized. Finally, a framework is presented linking steady-state airborne pathogen reduction and ozone concentration through their common dependence on average fluence rate. This relationship quantitatively demonstrates the trade-off between disinfection efficacy and ozone risk and provides a practical tool for realistic system design expectations and risk. Overall, this perspective emphasizes that fluence rate is the central design variable for Far-UVC air disinfection system design and that meaningful evaluation of both benefit and risk requires its accurate determination.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraviolet-C light for prevention of airborne infection: A baseline analysis of web-based public information.","authors":"Kathleen McPhaul, Young Yun, Donald K Milton, Cynthia Baur","doi":"10.1111/php.70135","DOIUrl":"https://doi.org/10.1111/php.70135","url":null,"abstract":"<p><p>Ultraviolet-C (UVC) technology to mitigate airborne infections was first demonstrated in laboratory and epidemiologic studies of influenza and measles in the 1930s, with effectiveness against tuberculosis demonstrated in the 1950s and again in the early 2000s. Yet, UVC was underutilized during the SARS CoV-2 pandemic (COVID-19). Availability, clarity, and actionability of information and messaging on UVC technology may have played a role in limiting policy discussions and uptake of UVC during the COVID-19 pandemic. The purpose of this analysis was to systematically assess the availability, clarity, and actionability of web-based information about UVC for preventing airborne respiratory infections. Student research assistants conducted internet searches using the Google Search engine after receiving a brief orientation to germicidal ultraviolet (GUV) air disinfection. They referred webpages from public health and regulatory organizations whose missions were to regulate UVC or provide recommendations for UVC to prevent transmission of airborne infectious pathogens to the principal investigator (PI). The PI determined whether the webpages met the inclusion criteria. The PI and a doctoral student with experience and training scored the final sample using the CDC's Clear Communication Index (CCI) which assessed public health information on clarity and actionability across four domains. Searches using the Google Search engine for information targeted to the general public yielded mostly commercial websites of UVC vendors, peer-reviewed papers, press releases on UVC research, and public health and regulatory agencies such as the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA), and the Centers for Disease Control and Prevention (CDC). We found that the public health and regulatory agencies have much room for improvement in the clarity, actionability, and integration with each other of their messaging and information. The lack of public policy and concerns about safety of UVC may be inhibiting clear and definitive public health messaging. Easily searchable UVC messaging on credible public health and regulatory websites has the potential to translate the peer-reviewed literature for lay audiences and improve public understanding of UVC for reducing airborne infections. In conclusion, this baseline analysis suggests a policy-communication gap in public-facing information about UVC for airborne infection prevention. More integrated, clear, and actionable guidance from neutral, authoritative organizations may support public understanding, informed discussion, and appropriate use of this potentially life-saving approach to protecting people in indoor spaces.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human ocular-discomfort-free thresholds for 222 nm Far-UVC irradiation: A prospective interventional study.","authors":"Sachiko Kaidzu, Kazunobu Sugihara, Masaki Tanito","doi":"10.1111/php.70137","DOIUrl":"https://doi.org/10.1111/php.70137","url":null,"abstract":"<p><p>The purpose of this study is to examine irradiation conditions of 222 nm Far-UVC that do not cause ocular discomfort to participants, considering both the irradiation intensity (ODF-IT; ocular-discomfort-free irradiance threshold) and irradiation dose (ODF-DT; ocular-discomfort-free dose threshold). A prospective, single-blind interventional study was conducted with 36 healthy adults exposed to 222 nm Far-UVC under five different irradiation conditions varying in intensity and total dose, along with a visible-light control condition. The irradiation device, placed under the TV monitor, delivered 222 nm Far-UVC or visible light to participants viewing the video. Ocular discomforts were recorded at multiple time points up to 24 h. Ophthalmic examinations-including slit lamp assessment, corneal fluorescein staining, and corneal endothelial cell density-were performed before and after irradiation. No adverse changes were observed in spherical equivalent refractive error, or corneal endothelial cell density under any condition. Corneal fluorescein staining occurred in some cases but showed no consistent correlation with ocular discomfort. Discomfort was significantly associated with radiant exposure dose, video viewing time and time after video viewing. The ODF-IT and ODF-DT values of 222 nm Far-UVC determined by the present study were around ≤1.0 μW/cm² and approximately 5.5 mJ/cm² respectively.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photophysical behavior and biological safety of YVO₄:Er,Yb upconversion nanocomposites decorated with Fe₃O₄ for optical-magnetic bioapplications.","authors":"C E Rivera-Enríquez, V-M Rodríguez-Betancourtt, F A Cholico, M E Cano, C Velásquez-Ordóñez","doi":"10.1111/php.70141","DOIUrl":"https://doi.org/10.1111/php.70141","url":null,"abstract":"<p><p>This work reports the synthesis, physicochemical characterization, and toxicity assessment of bifunctional YVO₄:Er,Yb@Fe₃O₄ nanocomposites designed for optical-magnetic bioapplications. Upconversion nanoparticles (UCNPs) of YVO₄:Er,Yb were synthesized and subsequently decorated with Fe₃O₄ nanoparticles. Nanocomposites exhibit superparamagnetic behavior and efficiently upconvert 980 nm near-infrared radiation (NIR) into visible green emission at 545 nm, making them attractive candidates for multimodal bioimaging. Structural, optical, and magnetic properties were analyzed by X-ray diffraction (XRD), Raman spectroscopy, photoluminescence (PL), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). A slight redshift of the characteristic vanadate Raman modes was observed, suggesting interfacial interactions between Fe²⁺/Fe³⁺ sites and Y-O or V-O surface groups. Upconversion emission intensity decreased with increasing magnetite content. The lifetime of the green ⁴S_3/2 → ⁴I_15/2 transition decreased from 5.11 to 4.62 microseconds upon magnetite decoration, indicating enhanced nonradiative relaxation. Toxicity assays using Artemia salina indicated that the nanocomposites are non-toxic, yielding LC₅₀ values of 204 ppm for YVO₄:Er,Yb, 698 ppm for Fe₃O₄, and 345 ppm for the nanocomposite containing 30 wt% Fe₃O₄. These results demonstrate that Fe₃O₄ decoration not only imparts magnetic functionality but also reduces the toxicity of UCNPs. The combined optical-magnetic properties and low toxicity support their potential use in photoactive nanomaterial systems.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitination-related gene signature in photoaging and prediction of candidate therapeutic agents.","authors":"Xinya Xu, Xinhua Lu","doi":"10.1111/php.70138","DOIUrl":"https://doi.org/10.1111/php.70138","url":null,"abstract":"<p><p>Photoaging is the major type of exogenous aging caused by chronic ultraviolet (UV) radiation, whose pathogenesis is complex and not fully understood. Recently, the involvement of ubiquitination in aging and aging-related disorders has aroused extensive attention. The present study aimed to investigate the relationship between ubiquitination and photoaging with bioinformatics. We utilized the GSE38308 dataset to screen the differentially expressed ubiquitination-related genes (UbR-DEGs), as well as immune infiltration and function, in the sun-exposed skin samples versus sun-protected controls. Based on the 46 UbR-DEGs, we performed enrichment analysis and protein-protein interaction (PPI) network analysis. Subsequently, the top five hub genes including UCHL1, HSP90AA1, YWHAQ, CTNNB1, and SNCA were identified and exhibited associations with immunological characteristics related to photoaging. Furthermore, the expression levels of hub genes were validated in clinical skin samples using qRT-PCR. Additionally, candidate therapeutic agents targeting the UbR-DEGs, such as myricetin and valproic acid, were predicted through gene-drug and protein-chemical interaction analysis. In conclusion, this study uncovered the intricate correlation between ubiquitination and photoaging, providing novel directions for investigations into photoaging pathogenesis and intervention strate gies.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calreticulin-targeting trisaccharide Glc-Man-Man conjugated with zinc chlorophyll derivative as a potential photosensitizer.","authors":"Mitsuaki Hirose, Yuka Kobayashi, Yoichi Takeda, Haruki Shimogaichi, Hitoshi Tamiaki, Taiki Kuribara, Kiichiro Totani","doi":"10.1111/php.70134","DOIUrl":"https://doi.org/10.1111/php.70134","url":null,"abstract":"<p><p>Calreticulin (CRT) is a multifunctional lectin involved in glycoprotein quality control and immune-associated cell surface signaling and has recently attracted attention as a potential molecular target in cancer-associated stress responses, including immunogenic cell death. We report the design and synthesis of a novel CRT-targeting trisaccharide (α-D-Glcp-(1 → 3)-α-D-Manp-(1 → 2)-Man, G1M2), G1M2-EG8-ZnChl, in which a CRT-recognizing trisaccharide is covalently linked to a zinc chlorophyll derivative (ZnChl) as a photosensitizer through an oligoethylene glycol spacer. The conjugate exhibited characteristic chlorin absorption bands at approximately 434 and 666 nm in aqueous buffer, enabling excitation in the red-light region. Upon light irradiation, singlet oxygen generation was confirmed using 1,3-diphenylisobenzofuran as a chemical quencher in ethanol, and the singlet oxygen quantum yield was determined to be Φ_Δ = 0.26. The complex showed negligible photodegradation under the irradiation for 80 s, indicating sufficient photostability of the chlorin core in G1M2-EG8-ZnChl. Binding assays demonstrated that G1M2-EG8-ZnChl interacted with human CRT through its glycan recognition domain and aglycon recognition domain. Although further biological investigations are required to elucidate cellular interactions and functional outcomes, this work demonstrates a molecular design strategy for integrating CRT-recognition motifs with photosensitizers while retaining essential photophysical and photochemical properties.</p>","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}