Photochemistry and Photobiology最新文献_第4页

Adjunctive use of Polypodium leucotomos extract in patients with erythropoietic protoporphyria: An exploratory study. 辅助使用白芍提取物治疗红细胞原卟啉症：一项探索性研究。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-03-02 DOI: 10.1111/php.70081

Nayha Shetty, Rebecca L Quiñonez, Marissa S Ceresnie, Sunita Ghosh, Henry W Lim, Tasneem F Mohammad

{"title":"Adjunctive use of Polypodium leucotomos extract in patients with erythropoietic protoporphyria: An exploratory study.","authors":"Nayha Shetty, Rebecca L Quiñonez, Marissa S Ceresnie, Sunita Ghosh, Henry W Lim, Tasneem F Mohammad","doi":"10.1111/php.70081","DOIUrl":"10.1111/php.70081","url":null,"abstract":"Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) cause severe photosensitivity, resulting in significant quality of life (QoL) impairment. This study aims to evaluate the safety and efficacy of Polypodium leucotomos extract (PLE) as an adjunctive therapy in patients with persistent symptoms despite standard dosing of afamelanotide. In this prospective single-center cohort study, eight adults with confirmed EPP or XLP and ongoing symptoms despite regular afamelanotide implants every 2 months were enrolled. Participants received 480 mg oral PLE daily for 4 months. QoL and symptom severity were measured using questionnaires at baseline, Day 60, and Day 120. Six participants completed the study. Statistically significant improvements in QoL were observed on Day 60 (p = 0.014), but not at Day 120 (p = 0.152). Half of participants reported reduced reaction severity. No adverse events occurred. Adjunctive PLE improved short-term QoL in participants with incomplete symptom control on afamelanotide alone and was well tolerated. Larger studies are warranted.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1095-1099"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilized CuCl₂/TiO₂ photocatalysts for the selective oxidation of benzyl alcohol to benzaldehyde. 固定化CuCl2/TiO2光催化剂在苯甲醇选择性氧化制苯甲醛中的应用。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-01-27 DOI: 10.1111/php.70072

Nosaibeh Nosrati-Ghods, Lidija Čuček, Hamidreza Moradi, Eric van Steen

{"title":"Immobilized CuCl2/TiO2 photocatalysts for the selective oxidation of benzyl alcohol to benzaldehyde.","authors":"Nosaibeh Nosrati-Ghods, Lidija Čuček, Hamidreza Moradi, Eric van Steen","doi":"10.1111/php.70072","DOIUrl":"10.1111/php.70072","url":null,"abstract":"The oxidation of alcohols to aldehydes is a key transformation in industrial chemistry, as aldehydes are vital intermediates in the synthesis of pharmaceuticals and fine chemicals. Conventional oxidation routes typically employ stoichiometric and corrosive oxidants, generating significant environmental concerns. Greener oxidants such as molecular oxygen (O2) offer a more sustainable alternative to stoichiometric oxidants; however, their efficient utilization requires activation by catalysts (e.g., Cu-, Pd-, Au-, or Ti-based systems). Homogeneous photocatalysts such as CuCl2 exhibit promising activity under light irradiation but are limited by challenges in separation and recycling. This study investigates the immobilization of CuCl2 and TiO2 (P25) within sodium alginate beads to facilitate photocatalyst recovery and minimize metal leaching. Under UV irradiation for 4 h, benzyl alcohol conversions of 54% (P25) and 49% (CuCl2) were achieved. Catalyst encapsulation markedly reduced activity due to internal mass transport limitations, as restricted diffusion of O2 and benzyl alcohol within the bead matrix limited access to active sites and suppressed overall reaction rates. Co-immobilization of P25 and CuCl2 partially restored conversion (22%), while maintaining high benzaldehyde selectivity (≈1 after 4 h) across all systems. These findings highlight oxygen depletion and mass transfer resistance as key constraints in bead-based photocatalysts. To guide further optimization, a MATLAB-based reactor model incorporating species transport, interfacial mass transfer, and kinetics was developed.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1220-1233"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146066013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of antibacterial photodynamic efficacy of a novel cationic near infrared chlorophyll derivative against planktonic and biofilm-borne methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. 一种新型阳离子近红外叶绿素衍生物对浮游和生物膜传播的耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌的光动力抗菌效果评价。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2025-12-29 DOI: 10.1111/php.70067

Sucharita Chatterjee, Alok Dube, Shovan Kumar Majumder

{"title":"Evaluation of antibacterial photodynamic efficacy of a novel cationic near infrared chlorophyll derivative against planktonic and biofilm-borne methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.","authors":"Sucharita Chatterjee, Alok Dube, Shovan Kumar Majumder","doi":"10.1111/php.70067","DOIUrl":"10.1111/php.70067","url":null,"abstract":"Antibacterial photodynamic therapy (aPDT) is a promising approach for inactivation of antibiotic-resistant bacteria; however, its effectiveness is compromised, particularly when bacteria hide within biofilm and if infection spreads deeper in tissue. To overcome this limitation, photosensitizers having absorption in the near-infrared region (NIR) (650-800 nm), where light penetrates deeper in tissue, need to be developed. We report aPDT efficacy of Cycloimide Purpurin-18 betaine hydrazide conjugate (CIPp-18-BH), a cationic chlorophyll derivative, against Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PAO). CIPp-18-BH was synthesized by conjugating CIPp-18 to betaine hydrazide (BH) using a carbodiimide coupling reaction. CIPp-18-BH, as compared to CIPp-18, exhibited lower lipophilicity; thereby, it did not aggregate in aqueous conditions and generated a substantial amount of singlet oxygen upon photo-excitation with red light. CIPp-18-BH exhibited no fluorescence in water and substantial fluorescence in less polar solvents. CIPp-18-BH bound to planktonic bacteria did not show fluorescence; whereas remarkable fluorescence was seen in biofilms, indicating it lies on the surface of bacteria and accumulates within the apolar micro-environment of biofilms. PDT of planktonic MRSA and PAO with 40 μM CIPp-18-BH led to ~7 log and ~2.5 log reduction in cell viability, respectively. Confocal microscopy showed that PDT led to substantial bacterial inactivation within MRSA and PAO biofilms, resulting in inhibition of biofilm growth by ~50% and ~20%, respectively. Results demonstrate that CIPp-18-BH is a promising photosensitizer for photodynamic inactivation of planktonic and biofilm-borne bacteria.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1259-1273"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Dendrobium nobile Lindl polysaccharides attenuate UVB-induced photodamage by regulating oxidative stress, inflammation and MMPs expression in mice model". 修正“石斛多糖通过调节小鼠模型的氧化应激、炎症和MMPs表达来减弱uvb诱导的光损伤”

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-07-29 DOI: 10.1111/php.70142

引用次数: 0

Light-emitting diode photobiomodulation on rheumatoid arthritis and osteoarthritis: In vitro and in vivo studies. 发光二极管对类风湿关节炎和骨关节炎的光生物调节：体外和体内研究。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-02-02 DOI: 10.1111/php.70077

Adenilson de Souza da Fonseca, Flávia de Paoli

{"title":"Light-emitting diode photobiomodulation on rheumatoid arthritis and osteoarthritis: In vitro and in vivo studies.","authors":"Adenilson de Souza da Fonseca, Flávia de Paoli","doi":"10.1111/php.70077","DOIUrl":"10.1111/php.70077","url":null,"abstract":"Light-emitting diodes (LEDs) are light sources that can be used for photobiomodulation to treat various diseases and clinical conditions. Growing evidence suggests that photobiomodulation is a promising treatment for rheumatoid arthritis (RA) and osteoarthritis (OA) because of its analgesic and anti-inflammatory effects. However, such evidence is primarily based on studies evaluating low-power laser-based photobiomodulation, and few studies have assessed the efficacy of LED photobiomodulation in the treatment of RA and OA. Thus, this study aimed to review studies on LED photobiomodulation for the treatment of RA and OA, summarizing the irradiation parameters and conditions, and reporting the study types and main results. Studies on the effects of LED photobiomodulation on RA and OA were accessed via PubMed. Data from accessed studies show that LED photobiomodulation has been carried out with red and infrared LEDs based on in vitro and in vivo experimental models. This therapy may decrease arthritic markers, including edema, hyperalgesia, inflammation, cartilage degradation, extracellular matrix alterations, and proinflammatory cytokine levels. LED photobiomodulation could be as effective a therapy as laser photobiomodulation, but further clinical studies are necessary to verify its therapeutic benefits in both RA and OA.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1079-1094"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of deposit homogeneity on sunscreen efficacy: A novel quantitative method using LC-OCT. 沉积均匀性对防晒功效的影响：一种新的LC-OCT定量方法

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-01-13 DOI: 10.1111/php.70068

Guillaume Votte, Annie Bossiere, Grégoire Guyon, Antoine Montaux-Lambert, Nathalie Blanpain, Rita Touti, Heiva Le Blay, Angelina Roudot

{"title":"Impact of deposit homogeneity on sunscreen efficacy: A novel quantitative method using LC-OCT.","authors":"Guillaume Votte, Annie Bossiere, Grégoire Guyon, Antoine Montaux-Lambert, Nathalie Blanpain, Rita Touti, Heiva Le Blay, Angelina Roudot","doi":"10.1111/php.70068","DOIUrl":"10.1111/php.70068","url":null,"abstract":"Performance of sunscreens is primarily optimized through the development of their organic or mineral filtering systems, that is, the core of their photoprotective action. However, numerous studies have underscored that the homogeneity of the applied deposit is also key to optimize the effectiveness of a given filtering systems. Quantifying the homogeneity of a coating presents a significant challenge, particularly on complex substrates such as skin. Therefore, there is a key challenge in being able to have robust methods to measure deposit homogeneity for both in vitro and in vivo ultraviolet tests. This work focused on developing new quantitative methods for evaluating sunscreen deposit and its homogeneity. Our approach involved adaptation line-field confocal optical coherence tomography, a technique commonly used in biology, to precisely assess the thickness distribution of sunscreen deposit. For this study, we specifically investigated deposit modifications without changing the filtering system, thereby successfully linking variations in deposit thickness and homogeneity directly to filtration performances. This new method not only can be leveraged to advance the development and improvement of new photoprotective technologies but also paves the way for a more comprehensive understanding and characterization of sunscreen applications, both in vivo and in vitro, leading to improved protection.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1185-1194"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired chitosan-zeolite composite: A green photocatalyst for water purification and energy-relevant oxidation reactions. 仿生壳聚糖-沸石复合材料：用于水净化和能源相关氧化反应的绿色光催化剂。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2025-12-08 DOI: 10.1111/php.70061

Anupma Yadav, Rajesh K Yadav, Arvind K Yadav, Kanchan Sharma, Shaifali Mishra, Rehana Shahin, Surendra K Jaiswal, Vinay K Mishra, Jin OoK Baeg

{"title":"Bioinspired chitosan-zeolite composite: A green photocatalyst for water purification and energy-relevant oxidation reactions.","authors":"Anupma Yadav, Rajesh K Yadav, Arvind K Yadav, Kanchan Sharma, Shaifali Mishra, Rehana Shahin, Surendra K Jaiswal, Vinay K Mishra, Jin OoK Baeg","doi":"10.1111/php.70061","DOIUrl":"10.1111/php.70061","url":null,"abstract":"The increasing contamination of aquatic systems by synthetic dyes such as methylene blue (MB) underscores the urgent need for sustainable and cost-effective wastewater treatment technologies. In this study, a novel biocomposite photocatalyst composed of chitosan and thermally treated ZSM-5 zeolite, denoted as ZSM-5 (800)/CS, was synthesized and systematically evaluated for its environmental remediation potential. The ZSM-5 (800)/CS composite exhibited superior photocatalytic activity, achieving 63% MB degradation within 210 min-significantly higher than pure chitosan, which achieved only 21% removal under identical conditions. The reduced optical bandgap (2.24 eV) of the biocomposite enhanced visible-light absorption, thereby improving its photocatalytic performance. Moreover, under aerobic conditions, ZSM-5 (800)/CS demonstrated excellent catalytic efficiency for the selective oxidation of organic sulfides to sulfoxides, achieving up to 96% yield and selectivity. These results highlight the dual functionality of the biocomposite for both wastewater detoxification and valuable chemical transformation. The study emphasizes the potential of integrating biopolymeric and zeolitic frameworks to develop sustainable photocatalysts that contribute to cleaner water resources and greener environmental technologies.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1234-1247"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebrafish as a practical and convenient model for the study of photodynamic and photothermal therapy of solid tumors: A scoping review. 斑马鱼作为实体肿瘤光动力和光热治疗研究的实用模型：综述。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-04-08 DOI: 10.1111/php.70096

Ethan Wilson, Alexander Fiorentino, Brian W Booth, Valery Bliznyuk, Diana Ivankovic, Luigi Boccuto

{"title":"Zebrafish as a practical and convenient model for the study of photodynamic and photothermal therapy of solid tumors: A scoping review.","authors":"Ethan Wilson, Alexander Fiorentino, Brian W Booth, Valery Bliznyuk, Diana Ivankovic, Luigi Boccuto","doi":"10.1111/php.70096","DOIUrl":"10.1111/php.70096","url":null,"abstract":"Thanks to incalculable efforts by teams of scientists and physicians over the past half-century, many cancer diagnoses that would have previously seemed terminal are now considered treatable or even curable with optimization of existing treatment strategies and the introduction of novel treatment methodologies. One rising treatment paradigm with the potential to improve patient outcomes and experiences is photomedicine, a group of light-activated treatments that can be applied systemically and activated locally. As the work of developing new phototherapeutic treatments and agents for use in cancer patients progresses, in vivo experimentation is a necessary hurdle, costing both time and resources. The use of zebrafish as a vertebrate tumor model for early-stage animal testing has the potential to increase the overall efficiency of the research process. Zebrafish are a model organism that allow for numerous tumor presentations and drug-delivery options to be tested at scale with a low turnaround time relative to other in vivo vertebrate models. The transparency of an embryonic or larval zebrafish's body allows for real-time observation of drug dispersal and effects of treatment. These qualities allow zebrafish to serve as a useful screening tool for identifying promising candidate photosensitizers before embarking on mammalian studies.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1060-1078"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photophysics of hydroxy-nitrobenzoic acid UV-MALDI matrices investigated via spectroscopic, photoacoustic, and luminescence techniques. 利用光谱学、光声和发光技术研究羟基-硝基苯甲酸UV-MALDI基质的光物理性质。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-01-05 DOI: 10.1111/php.70070

Oscar E Silva Rodriguez, Gabriela Petroselli, Pedro M David Gara, Hernán B Rodríguez, Rosa Erra-Balsells

{"title":"Photophysics of hydroxy-nitrobenzoic acid UV-MALDI matrices investigated via spectroscopic, photoacoustic, and luminescence techniques.","authors":"Oscar E Silva Rodriguez, Gabriela Petroselli, Pedro M David Gara, Hernán B Rodríguez, Rosa Erra-Balsells","doi":"10.1111/php.70070","DOIUrl":"10.1111/php.70070","url":null,"abstract":"The photophysical behavior of novel UV-MALDI matrices belonging to the family of hydroxy-nitrobenzoic acids (HNBAs) was investigated in both acetonitrile and methanol solutions, as well as in the solid state, using spectroscopic, luminescence, and photoacoustic techniques. The study focused on the following positional isomers: 2-hydroxy-3-nitrobenzoic acid, 2-hydroxy-4-nitrobenzoic acid, 2-hydroxy-5-nitrobenzoic acid, 3-hydroxy-2-nitrobenzoic acid, 3-hydroxy-4-nitrobenzoic acid, 3-hydroxy-5-nitrobenzoic acid, 4-hydroxy-3-nitrobenzoic acid, and 5-hydroxy-2-nitrobenzoic acid. Most isomers exhibited strong solid-state absorption at the excitation wavelengths commonly used in UV-MALDI technique (>90% at 337 and 355 nm), high photostability, no detectable luminescence, and highly efficient excitation energy dissipation as prompt heat, resembling the behavior of calorimetric references under both N2- and air-saturated conditions, suggesting a potential role in facilitating desorption/ionization processes in UV-MALDI. These findings provide valuable insight into the performance of HNBAs as matrix candidates.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"1169-1184"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial (2026, issue 5, September/October). 社论（2026年9月/ 10月第5期）。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2026-09-01 Epub Date: 2026-08-14 DOI: 10.1111/php.70144

Alexander Greer

引用次数: 0