Photochemistry and Photobiology最新文献_第4页

Gut microbiota mediates the anti-inflammatory effects of supplemental infrared irradiation in mice. 肠道微生物群介导补充红外线照射对小鼠的抗炎作用

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-30 DOI: 10.1111/php.14008

Shijing Wang, Letian Chen, Zheng Ma, Liting Zhao, Yueying Lu, Yuming Fu, Hong Liu

{"title":"Gut microbiota mediates the anti-inflammatory effects of supplemental infrared irradiation in mice.","authors":"Shijing Wang, Letian Chen, Zheng Ma, Liting Zhao, Yueying Lu, Yuming Fu, Hong Liu","doi":"10.1111/php.14008","DOIUrl":"10.1111/php.14008","url":null,"abstract":"In recent years, studies have shown that low-dose supplemental infrared (IR) irradiation exhibits systemic anti-inflammatory effects. The gut microbiota is increasingly recognized as a potential mediator of these effects due to its role in regulating host metabolism and inflammatory responses. To investigate the role of gut microbiota diversity and metabolite changes in the mechanism of light-emitting diodes (LED) infrared's anti-inflammatory action, we conducted IR irradiation on mice. Serum inflammatory cytokines were measured using ELISA, and fecal samples were subjected to metagenomic, untargeted, and targeted metabolomic analyses. Our results demonstrated a significant increase in the anti-inflammatory cytokine IL-10 in the IR group, accompanied by a declining trend in pro-inflammatory cytokines. Gut microbiome analysis revealed distinct alterations in composition and functional genes between the groups, including the enrichment of beneficial bacteria like various species of Parabacteroides and Akkermansia muciniphila in the IR group. Notably, the IR group exhibited enrichment in carbohydrate metabolism pathways and a reduction in DNA damage and repair pathways. Furthermore, targeted metabolomic analysis highlighted a notable increase in short-chain fatty acids (SCFAs), including butyric acid and isobutyric acid, which positively correlated with the abundance of several beneficial bacteria. These findings suggest a potential interplay between gut microbiota-derived SCFAs and the anti-inflammatory response. In conclusion, our study provides comprehensive insights into the changes in gut microbiota species and functions associated with IR irradiation. Moreover, we emphasize the significance of altered SCFAs levels in the IR group, which may contribute to the observed anti-inflammatory effects. Our findings contribute valuable evidence supporting the role of low-dose infrared light irradiation as an anti-inflammatory therapy.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"458-470"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV-induced skin damage. NEO400（与亚油酸共轭的紫苏醇）对紫外线引起的皮肤损伤小鼠模型的治疗效果。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-05 DOI: 10.1111/php.13998

Stephen Swenson, Catalina Silva-Hirschberg, Liliana Freeland, Kristen L Chen, Nagore I Marín-Ramos, Axel H Schönthal, Thomas C Chen

{"title":"Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV-induced skin damage.","authors":"Stephen Swenson, Catalina Silva-Hirschberg, Liliana Freeland, Kristen L Chen, Nagore I Marín-Ramos, Axel H Schönthal, Thomas C Chen","doi":"10.1111/php.13998","DOIUrl":"10.1111/php.13998","url":null,"abstract":"Excessive exposure to ultraviolet radiation (UVR) causes harmful effects on human skin. Pre-exposure application of sunscreen can be protective, but not after damage already has occurred. There is a need for agents that can be applied post-UVR exposure to repair the damage. We investigated a novel compound, NEO400, that appears to meet this medicinal need. NEO400 was created by conjugating linoleic acid to perillyl alcohol. UVR was repeatedly administered to the skin of mice over several weeks, where it caused the typical signs of UV damage, including scaling of the skin, DNA damage, and elevated levels of inflammatory cytokines. However, when NEO400 was applied immediately post-UVR, it triggered the appearance of markers for dermal stem cell proliferation, and no signs of skin damage emerged. Furthermore, when NEO400 was applied to skin that already had incurred significant damage, it accelerated skin healing. When applied individually, linoleic acid and perillyl alcohol were ineffective, indicating that they had to be conjugated in order to exert therapeutic efficacy. None of these skin-protective effects could be achieved with Aloe vera gel, a popular and widely used post-exposure remedy. Our study suggests that NEO400 holds potential as a regenerative treatment for excessively UVR-exposed skin.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"338-349"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma classification using generative adversarial network and proximal policy optimization. 利用生成式对抗网络和近端策略优化进行黑色素瘤分类。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-30 DOI: 10.1111/php.14006

Xiangui Ju, Chi-Ho Lin, Suan Lee, Sizheng Wei

{"title":"Melanoma classification using generative adversarial network and proximal policy optimization.","authors":"Xiangui Ju, Chi-Ho Lin, Suan Lee, Sizheng Wei","doi":"10.1111/php.14006","DOIUrl":"10.1111/php.14006","url":null,"abstract":"In oncology, melanoma is a serious concern, often arising from DNA changes caused mainly by ultraviolet radiation. This cancer is known for its aggressive growth, highlighting the necessity of early detection. Our research introduces a novel deep learning framework for melanoma classification, trained and validated using the extensive SIIM-ISIC Melanoma Classification Challenge-ISIC-2020 dataset. The framework features three dilated convolution layers that extract critical feature vectors for classification. A key aspect of our model is incorporating the Off-policy Proximal Policy Optimization (Off-policy PPO) algorithm, which effectively handles data imbalance in the training set by rewarding the accurate classification of underrepresented samples. In this framework, the model is visualized as an agent making a series of decisions, where each sample represents a distinct state. Additionally, a Generative Adversarial Network (GAN) augments training data to improve generalizability, paired with a new regularization technique to stabilize GAN training and prevent mode collapse. The model achieved an F-measure of 91.836% and a geometric mean of 91.920%, surpassing existing models and demonstrating the model's practical utility in clinical environments. These results demonstrate its potential in enhancing early melanoma detection and informing more accurate treatment approaches, significantly advancing in combating this aggressive cancer.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"434-457"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Far-UVC: The impact of optical filters on real-world deployment. 远紫外线：光学滤波器对实际部署的影响。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-20 DOI: 10.1111/php.14005

Ewan Eadie, Paul O'Mahoney, Sally H Ibbotson, C Cameron Miller, Kenneth Wood

{"title":"Far-UVC: The impact of optical filters on real-world deployment.","authors":"Ewan Eadie, Paul O'Mahoney, Sally H Ibbotson, C Cameron Miller, Kenneth Wood","doi":"10.1111/php.14005","DOIUrl":"10.1111/php.14005","url":null,"abstract":"In 2015, a study showed that Krypton-Chloride (KrCl) excimer lamps could induce erythema and basal layer DNA damage in human skin. Later studies found that filtering out longer wavelength emissions from these lamps resulted in no acute skin effects. However, there is a limited understanding of how much to reduce unwanted emissions and which wavelengths are important. Accurate spectral irradiance data is therefore crucial for safety, as variance in optical filtering significantly affects the weighted irradiance of a lamp. To simplify the risk assessment process for Far-UVC lamps, we highlight the usefulness of the lamp exposure limit (HLEL) and present this in the context of spectral emission data for 14 commercially available Far-UVC lamps. Our results demonstrate that relying solely on a radiometric measurement and a single-wavelength exposure limit at 222 nm could lead to over-exposure. The HLEL is a practical metric which can be utilized to determine the exposure time before reaching the exposure limit. It can also be used in the determination of the minimum ceiling height for compliance with standards like UL 8802. Manufacturers are urged to provide HLEL for their products; installers should adhere to HLEL; and standards and regulatory bodies should insist on this information in new guidance.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"270-274"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the efficacy of antimicrobial photodynamic therapy through curcumin modifications. 通过姜黄素改性提高抗菌光动力疗法的疗效。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-24 DOI: 10.1111/php.14000

Priyanka Joshi, Jennifer M Soares, Guilherme M Martins, Leandro H Zucolotto Cocca, Leonardo De Boni, Kleber T de Oliveira, Vanderlei S Bagnato, Kate C Blanco

{"title":"Enhancing the efficacy of antimicrobial photodynamic therapy through curcumin modifications.","authors":"Priyanka Joshi, Jennifer M Soares, Guilherme M Martins, Leandro H Zucolotto Cocca, Leonardo De Boni, Kleber T de Oliveira, Vanderlei S Bagnato, Kate C Blanco","doi":"10.1111/php.14000","DOIUrl":"10.1111/php.14000","url":null,"abstract":"Curcumin serves as a photosensitizer (PS) in the context of microbial inactivation when subjected to light exposure, to produce reactive oxygen species, which exhibit efficacy in eradicating microorganisms. This remarkable property underscores the growing potential of antimicrobial photodynamic therapy (aPDT) in the ongoing fight against bacterial infections. Considering this, we investigate the efficacy of various in vitro curcumin formulations within a PDT protocol designed to target Staphylococcus aureus. Specifically, we conduct a comparative analysis involving synthetic curcumin (Cur-Syn) and curcumin derivatives modified with chlorine (Cl), selenium (Se), and iodine (I) (Cur-Cl, Cur-Se, Cur-I). To assess the impact of aPDT, we subject S. aureus to incubation with curcumin, followed by irradiation at 450 nm with energy doses of 3.75, 7.5, and 15 J/cm2. Our investigation encompasses an evaluation of PS uptake and photobleaching across the various curcumin variants. Notably, all three modifications (Cur-Cl, Cur-Se, Cur-I) induce a significant reduction in bacterial viability, approximately achieving a 3-log reduction. Interestingly, the uptake kinetics of Cur-Syn and Cur-Se exhibit similarities, reaching saturation after 20 min. Our findings suggest that modifications to curcumin have a discernible impact on the photodynamic properties of the PS molecule.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"359-372"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression profiles and functional analysis of transfer RNA-derived small RNAs (tsRNAs) in photoaged human dermal fibroblasts. 转运核糖核酸衍生的小核糖核酸（tsRNA）在光老化的人类真皮成纤维细胞中的表达谱和功能分析。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-08-30 DOI: 10.1111/php.14015

Amin Yao, Yu Zhang, Mengting Ouyang, Lei Wen, Wei Lai

{"title":"Expression profiles and functional analysis of transfer RNA-derived small RNAs (tsRNAs) in photoaged human dermal fibroblasts.","authors":"Amin Yao, Yu Zhang, Mengting Ouyang, Lei Wen, Wei Lai","doi":"10.1111/php.14015","DOIUrl":"10.1111/php.14015","url":null,"abstract":"Transfer RNA-derived small RNAs (tsRNAs) refer to a newly established family of non-coding RNAs that regulate a diverse set of biological processes. However, the function of tsRNAs in skin photoaging remains unclear. This research aims to investigate the potential correlation between tsRNAs and skin photoaging. Human dermal fibroblasts (HDFs) were irradiated with UVA at 10 J/cm2 once a day lasting for 14 days, resulting in the establishment of a photoaging model induced by UVA. To identify the expression profiles and functions of tsRNAs, tsRNA sequencing and bioinformatics analysis were conducted. qPCR was employed to validate the results of differentially expressed (DE) tsRNAs. A total of 34 tsRNAs exhibited significant differential expression between the UVA and control groups (n = 3), with nine upregulated and 25 downregulated (log2 fold change >1.5, p-value <0.05). Six tsRNAs were selected at random and validated by qRT-PCR. The enrichment analysis of DE tsRNAs target genes indicated that the dysregulated tsRNAs appeared to be connected with cell cycle, DNA replication and the AGE-RAGE signaling pathway. The expression of tsRNAs was found to be aberrant in UVA-HDF. These findings provide insights into the UVA-induced damage and potential target genes for skin photoaging.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"505-516"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the ESIPT process in benzoxazole fluorophores within polymeric matrices through theory and experiment. 通过理论和实验揭示聚合物基质中苯并噁唑荧光团的 ESIPT 过程。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-06-26 DOI: 10.1111/php.13991

Luís Gustavo Teixeira Alves Duarte, Emmanuel Santos Moraes, Priscila Sayoko Silva Wakabayashi, Lilian Camargo da Luz, Rodrigo Cercená, Eduardo Zapp, Teresa Dib Zambon Atvars, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch

{"title":"Revealing the ESIPT process in benzoxazole fluorophores within polymeric matrices through theory and experiment.","authors":"Luís Gustavo Teixeira Alves Duarte, Emmanuel Santos Moraes, Priscila Sayoko Silva Wakabayashi, Lilian Camargo da Luz, Rodrigo Cercená, Eduardo Zapp, Teresa Dib Zambon Atvars, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch","doi":"10.1111/php.13991","DOIUrl":"10.1111/php.13991","url":null,"abstract":"The impact of the polymeric matrix on the photophysical characteristics of monomeric dyes responsive to excited-state intramolecular proton transfer (ESIPT) was investigated through UV-Vis absorption as well as steady-state and time-resolved emission spectroscopies. For this purpose, two benzoxazole monomers (M1 and M2) with acryloyl groups at different positions in their molecular structures were employed to facilitate covalent bonding within a styrene chain. Our findings reveal significant variations in their excited-state properties due to the proximity of the acryloyl groups, which affects the energy barrier of the ESIPT reaction, the emission wavelength, and the balance between the normal and tautomeric forms. The experimental results were corroborated through theoretical investigations at the DFT/TDDFT level, specifically using the B3LYP-D3/def2-TZVP methodology. Three notable observations emerged: donor/acceptor groups at the meta/para positions induced electron distribution changes, causing red-shifted emission for M2; in the polymer film, particularly in PM1, intramolecular hydrogen bond deactivation favored N* emission over T* emission; and the zwitterionic character of the T* species. This study underscores the advantages of functionalization in polymers, which can lead to colorless films and prevalent N* or T* emission, and contributes valuable insights into molecular design strategies for tailoring the photophysical properties of polymeric materials.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"290-301"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis to evaluate the effects of solar exposure and a broad-spectrum SPF50+ sunscreen on markers of skin barrier function in a skin ecosystem model. 在皮肤生态系统模型中，通过多组学分析评估日光照射和广谱 SPF50+ 防晒霜对皮肤屏障功能标志物的影响。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.1111/php.14001

Carine Jacques, Emilien L Jamin, Anais Noustens, Christophe Lauze, Isabelle Jouanin, Gautier Doat, Laurent Debrauwer, Sandrine Bessou-Touya, Eggert Stockfleth, Hélène Duplan

{"title":"Multi-omics analysis to evaluate the effects of solar exposure and a broad-spectrum SPF50+ sunscreen on markers of skin barrier function in a skin ecosystem model.","authors":"Carine Jacques, Emilien L Jamin, Anais Noustens, Christophe Lauze, Isabelle Jouanin, Gautier Doat, Laurent Debrauwer, Sandrine Bessou-Touya, Eggert Stockfleth, Hélène Duplan","doi":"10.1111/php.14001","DOIUrl":"10.1111/php.14001","url":null,"abstract":"Sun exposure induces major skin alterations, but its effects on skin metabolites and lipids remain largely unknown. Using an original reconstructed human epidermis (RHE) model colonized with human microbiota and supplemented with human sebum, we previously showed that a single dose of simulated solar radiation (SSR) significantly impacted the skin metabolome and microbiota. In this article, we further analyzed SSR-induced changes on skin metabolites and lipids in the same RHE model. Among the significantly altered metabolites (log2-fold changes with p ≤ 0.05), we found several natural moisturizing factors (NMFs): amino acids, lactate, glycerol, urocanic acid, pyrrolidone carboxylic acid and derivatives. Analyses of the stratum corneum lipids also showed that SSR induced lower levels of free fatty acids and higher levels of ceramides, cholesterols and its derivatives. An imbalance in NMFs and ceramides combined to an increase of proinflammatory lipids may participate in skin permeability barrier impairment, dehydration and inflammatory reaction to the sun. Our skin model also allowed the evaluation of an innovative ultraviolet/blue light (UV/BL) broad-spectrum sunscreen with a high sun protection factor (SPF50+). We found that using this sunscreen prior to SSR exposure could in part prevent SSR-induced alterations in NMFs and lipids in the skin ecosystem RHE model.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"373-385"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultraviolet irradiation benefits left ventricular hypertrophy and mitochondrial morphology of cardiomyocytes in hypertensive rats. 紫外线照射有益于高血压大鼠左心室肥厚和心肌细胞线粒体形态。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-07-23 DOI: 10.1111/php.14002

Hiroki Shibata, Akiko Noda, Yuji Nishizawa, Atsuki Ito, Takahiro Okumura, Katsunori Hashimoto, Kozue Takeda, Kimiaki Katanosaka, Fumihiko Yasuma, Shiyong Wu

{"title":"Ultraviolet irradiation benefits left ventricular hypertrophy and mitochondrial morphology of cardiomyocytes in hypertensive rats.","authors":"Hiroki Shibata, Akiko Noda, Yuji Nishizawa, Atsuki Ito, Takahiro Okumura, Katsunori Hashimoto, Kozue Takeda, Kimiaki Katanosaka, Fumihiko Yasuma, Shiyong Wu","doi":"10.1111/php.14002","DOIUrl":"10.1111/php.14002","url":null,"abstract":"Insufficient exposure to sunlight increases the risk of cardiovascular diseases. Hypertensive left ventricular (LV) hypertrophy exacerbates the risks of myocardial ischemia, ventricular arrhythmias, sudden cardiac death, and heart failure. This study aimed to determine the effects of ultraviolet (UV) irradiation on LV hypertrophy and mitochondrial morphology. Eighteen 7-week-old Dahl salt-sensitive (Dahl S) rats were categorized into three groups (n = 6 each) and fed sodium chloride (NaCl) diets, as follows: UV-irradiated [UVB+A (+), 8% NaCl], non-UV-irradiated [UV (-), 8% NaCl], and control [UV (-), 0.3% NaCl]. UV irradiation was administered at a low intensity of 100 mJ/cm2 for 6 days per week. Echocardiography and mitochondrial analyses were performed to evaluate LV hypertrophy and cardiomyocytes, and skin tissues were stained with hematoxylin and eosin to assess the pathological abnormalities at 12 weeks of age. LV mass was significantly reduced in the UVB+A (+) and control groups compared to that in the UV (-) group. Mitochondrial structural abnormalities in cardiomyocytes were observed only in the UV (-) group, but not in the UVB+A (+) or control group. Pathological skin abnormalities were not observed in any of the three groups. These findings suggest the potential benefits of UV irradiation in hypertensive models.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"386-391"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-free functionalized carbon nitride as a photocatalyst driven by sunlight for acetal synthesis and selective regeneration of NAD(P)H cofactor. 无金属功能化氮化碳作为光催化剂，在阳光驱动下进行缩醛合成和 NAD(P)H 辅因子的选择性再生。

IF 2.6 4区生物学

Photochemistry and Photobiology Pub Date : 2025-03-01 Epub Date: 2024-08-16 DOI: 10.1111/php.14011

Shaifali Mishra, Rajesh K Yadav, Dinesh K Mishra, Kuldeep Kumar, Navneet Kumar Gupta, Kuldeep Singh, Satyaveer Gothwal, Jin-OoK Baeg

{"title":"Metal-free functionalized carbon nitride as a photocatalyst driven by sunlight for acetal synthesis and selective regeneration of NAD(P)H cofactor.","authors":"Shaifali Mishra, Rajesh K Yadav, Dinesh K Mishra, Kuldeep Kumar, Navneet Kumar Gupta, Kuldeep Singh, Satyaveer Gothwal, Jin-OoK Baeg","doi":"10.1111/php.14011","DOIUrl":"10.1111/php.14011","url":null,"abstract":"Nicotinamide Adenine Dinucleotide Phosphate (NAD(P)H) plays an important role in numerous biologically significant redox reactions. The photochemical restoration of its oxidized form (NAD(P)+) under physiological conditions is intriguing in the context of integrated photo and catalysis. Herein, we report the functionalized graphitic carbon-based solar light active photocatalyst by doping boron and fluorine in the native graphitic carbon nitride (GCN) (nonfunctionalized) for the regeneration of enzymatically visible light active coenzyme and in photo-acetalization reactions. The metal-free functionalized photocatalyst systems such as BFGCN-x leads to higher yield NADH and NADPH regeneration. They are also capable of catalyzing acetal reactions in the absence of any Lewis and Bronsted acids. The current research endeavor provides the advancement and the application of functionalized GCN-based photocatalysts for NADH (61.89%), NADPH (59.84%) regeneration, and photo-acetalization reactions.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"471-482"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0