Photochemistry and Photobiology最新文献_第4页

Polo-like kinases and UV-induced skin carcinogenesis: What we know and what's next. 马球样激酶和紫外线诱发的皮肤癌：我们所知道的和接下来的研究。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-07-09 DOI: 10.1111/php.70002

Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad

{"title":"Polo-like kinases and UV-induced skin carcinogenesis: What we know and what's next.","authors":"Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad","doi":"10.1111/php.70002","DOIUrl":"10.1111/php.70002","url":null,"abstract":"Prolonged and chronic exposure to UV radiation is a risk factor for multiple skin cancers. As the incidence of UV-associated skin cancers continues to rise, there is a pressing need for a deeper understanding of the underlying mechanisms driving these pathologies. Polo-like kinases (PLKs), a family of enzymes consisting of five members (PLK1-PLK5), have been implicated in various aspects of skin carcinogenesis. The inhibition of PLKs is currently being explored as a potential strategy for cancer management. While much of the research has predominantly concentrated on PLK1, recent studies are increasingly shedding light on the role of other PLK family members, given their growing importance in cancer progression. Understanding the relationship between UV-associated skin cancers and PLKs could open new avenues for more effective management of skin cancers. In this review, we discuss the critical mechanisms associated with UV and PLKs in causing skin cancers, followed by the potential role of UV in modulating PLKs in different skin cancers. We also examine the prospect of targeting PLK signaling to enhance therapies for UV-induced skin cancer and improve patient responses. So far, there is not enough literature focused on the simultaneous effects of PLKs and UV using skin cancer models, emphasizing the need for further research to completely understand the role of PLKs in UV-induced skin carcinogenesis.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"276-289"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating genome repair by photolyase. 光解酶照亮基因组修复。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-10-22 DOI: 10.1111/php.70047

Marian F Laughery, John J Wyrick

引用次数: 0

222 nm far-UVC light and skin health: Assessment of DNA damage across different skin types. 222nm远紫外线光与皮肤健康：不同皮肤类型的DNA损伤评估

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-07-09 DOI: 10.1111/php.70010

Manuela Buonanno, Camryn Petersen, David Welch, Raabia Hashmi, David J Brenner

{"title":"222 nm far-UVC light and skin health: Assessment of DNA damage across different skin types.","authors":"Manuela Buonanno, Camryn Petersen, David Welch, Raabia Hashmi, David J Brenner","doi":"10.1111/php.70010","DOIUrl":"10.1111/php.70010","url":null,"abstract":"Due to a limited penetration into skin and eyes combined with a broad germicidal effectiveness, far-UVC light (200-235 nm) has been proposed as an effective intervention for airborne pandemic control. Specifically, 222 nm light is not predicted to damage skin because it is primarily absorbed by the proteins in the superficial stratum corneum of the epidermis. Thus, it is hypothesized that the thickness of the stratum corneum is one of the most significant contributing factors to the risk of skin damage from exposure to far-UVC. From measurements of the stratum corneum thickness in live human skin biopsies, it was found that none of the donor demographics studied had an impact on the thickness of the stratum corneum. While multiple studies suggest that exposure to 222 nm is minimally damaging to skin, a few studies to date have investigated effects as a function of skin characteristics (e.g., individual's age and sex). In selected tissues, the induction of DNA damage following an acute exposure to 100 or 500 mJ/cm2 from 222 nm light was analyzed as a function of donor demographics. The results agree with previous studies using other models of human skin and show that in human skin biopsies, 222 nm induces minor DNA damage only at high doses, especially in skin with low melanin content (phototype).","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"400-410"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm. 一种创新的波长为234nm的UVC光疗装置的杀菌潜力和皮肤相容性。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-07-30 DOI: 10.1111/php.70016

Zheng Tang, David Welch, Manuela Buonanno, Mark Gerber, David J Brenner

{"title":"Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm.","authors":"Zheng Tang, David Welch, Manuela Buonanno, Mark Gerber, David J Brenner","doi":"10.1111/php.70016","DOIUrl":"10.1111/php.70016","url":null,"abstract":"Chronic wounds are a major healthcare issue affecting more than 10 million Americans each year, with a 5-year survival similar to cancer and costing the healthcare system billions of dollars annually. Current solutions, such as antiseptics and antibiotics, can be toxic to cells or contribute to the development of antibiotic-resistant strains of bacteria. Exposure to germicidal ultraviolet radiation (GUV) at 254 nm has been reported as an effective method for chronic wound management. However, concerns about the health hazards from exposure to 254 nm radiation have limited its use for wound management applications. In contrast, wavelengths of ultraviolet radiation in the range of 200-235 nm have exhibited similar germicidal ability but with a lower penetration range in tissue, potentially making those wavelengths better suited for chronic wound disinfection. In this study, a novel phototherapy device emitting principally at 234 nm was used to assess the killing efficacy against Methicillin-resistant Staphylococcus aureus (MRSA). Potential health hazards from exposure using the device were evaluated using a 3D human skin model. The ultraviolet exposure device tested in this study shows promise for effective decontamination of chronic nonhealing wounds without associated health hazards.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"411-417"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of luciferase from an Indian firefly Abscondita sp. (Coleoptera: Lampiridae). 一种印度隐翅萤（鞘翅目：萤科）荧光素酶的鉴定。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-06-18 DOI: 10.1111/php.70001

Yasuo Mitani, Shusei Kanie, Sosmitha Girisa, Ajaikumar B Kunnumakkara, Sunil C Kaul, Yoshihiro Ohmiya

{"title":"Characterization of luciferase from an Indian firefly Abscondita sp. (Coleoptera: Lampiridae).","authors":"Yasuo Mitani, Shusei Kanie, Sosmitha Girisa, Ajaikumar B Kunnumakkara, Sunil C Kaul, Yoshihiro Ohmiya","doi":"10.1111/php.70001","DOIUrl":"10.1111/php.70001","url":null,"abstract":"Among the luminescent animals, fireflies have been extensively investigated throughout the world. Enzymatic characterization using recombinant proteins has been achieved after the first cloning of the Photinus pyralis luciferase gene. Firefly luciferase is pH sensitive, emitting a red-shifted color when the pH of the reaction buffer is lowered. This trait is only known for fireflies and not in other luminescent beetles, including click beetles (Elateridae) and railroad worms (Phengodidae). Until now, firefly luciferases from North America, Central and South America, Europe, and East Asia have been intensively studied. Recently, molecular phylogenetic analyses using mitochondrial DNA have revealed relationships between firefly species in South Asia and India. However, the enzymatic characterization of luciferases from such species has not been thoroughly investigated. Here, we collected a firefly in India and enzymatically characterized its luciferase. Molecular phylogenetic analysis using cytochrome oxidase I suggested that this firefly is closely related to the genus Abscondita. The luciferase gene obtained from the RNA sequencing (RNA-Seq) was expressed using Escherichia coli and was used to characterize the luciferase. Its optimum temperature and pH were 30°C and 7.0, respectively. The maximum emission wavelength was around 570 nm when a pH 6.0 or 8.0 reaction buffer was used, and no apparent red shift was observed.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"504-510"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publishing in Photochemistry and Photobiology: A suitable platform for photoscience dissemination. 发表于光化学和光生物学：一个适合于光科学传播的平台。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1111/php.70063

Jean Cadet

引用次数: 0

Analysis of singlet oxygen transport from air to surface by phosphorescence-slope inflection angle (SIA) approach. 用磷光-坡折角（SIA）方法分析空气到地表的单线态氧输运。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-06-02 DOI: 10.1111/php.14125

Serah Essang, Akshaya Iyer, Andrés M Durantini, Alexander Greer

{"title":"Analysis of singlet oxygen transport from air to surface by phosphorescence-slope inflection angle (SIA) approach.","authors":"Serah Essang, Akshaya Iyer, Andrés M Durantini, Alexander Greer","doi":"10.1111/php.14125","DOIUrl":"10.1111/php.14125","url":null,"abstract":"Singlet oxygen (1O2) is a reactive species that plays a role in environmental and biological surface chemistry; however, the mechanisms of the association of airborne 1O2 at the air/surface interface are poorly known. Here, we help resolve this problem using 1O2's near-infrared (NIR) phosphorescence and geometric analysis based on the slope inflection angle (θ) of air-to-particle transfer. This offers insight into 1O2-surface binding as opposed to conventional kinetic analysis. Two 9,10-disubstituted anthracene quenchers were adsorbed to the particle surface, producing θ ranging from ~91° (greater quenching) to ~99° (less quenching) due to the reduction of airborne 1O2 lifetime (τairborne) by 43% to 95%. A more efficient (lower θ) 1O2 quenching is observed in the order dimethylanthracene-coated particle > anthracene dianion-coated particle > native silica. The anthracene dianion charges and surface silanols did not enhance the 1O2 surface quenching. Indeed, the quenching of airborne 1O2 by native silica was minimal, in which a slight reduction in its surface lifetime (τsurf) was observed (0-5%). This θ approach opens up opportunities in fields such as surface oxidation processes in nanoplastics, which is an emerging concern.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"351-361"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of pharmacotherapeutic activity of antibiotic "Amphotericin B" due to its photosensitizing properties. 抗生素“两性霉素B”因其光敏特性而增强药物治疗活性。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-07-20 DOI: 10.1111/php.70014

Nadezhda I Schastnaya, Tatyana E Kuznetsova, Hanna E Pyzh, Aliaksandr V Mikulich, Antonina I Tretyakova, Tatsiana S Ananich, Ludmila G Plavskaya, Vitaly Yu Plavskii

{"title":"Enhancement of pharmacotherapeutic activity of antibiotic \"Amphotericin B\" due to its photosensitizing properties.","authors":"Nadezhda I Schastnaya, Tatyana E Kuznetsova, Hanna E Pyzh, Aliaksandr V Mikulich, Antonina I Tretyakova, Tatsiana S Ananich, Ludmila G Plavskaya, Vitaly Yu Plavskii","doi":"10.1111/php.70014","DOIUrl":"10.1111/php.70014","url":null,"abstract":"The problem of increasing the efficacy of fungal infection treatment is a pressing issue in modern medicine due to increasing resistance of pathogenic microorganisms to antifungal drugs. At the same time, the development of new antifungal drugs is a complex, lengthy, and expensive task, since there is a close evolutionary relationship between fungal eukaryotes and human somatic cells. The aim of this work is to enhance the pharmacotherapeutic activity of the widely used antifungal polyene antibiotic \"Amphotericin B\". As a result of in vitro studies using somatic cells, the ability of Amphotericin B to act as a photosensitizer when exposed to light in the blue spectral region, corresponding to the absorption band of the drug, as well as to sensitize the Type II photochemical reactions (generation of singlet oxygen) and radical processes (Type I reactions) was demonstrated. When modeling contact dermatitis on depilated areas of rat skin, it was found that the combined use of Amphotericin B and radiation from super-bright LEDs with a wavelength of λmax = 405 nm enhances the fungicidal effect of the drug and also causes a reliable decrease in the characteristic signs of dermatitis compared to the effect of each of the specified factors separately. The results obtained can find wide application in medical practice for the treatment of fungal lesions of the skin, oral cavity, female genital area, and so forth. The presence of photosensitizer (Amphotericin B), approved for use, and phototherapeutic equipment corresponding to its absorption spectrum make it possible to develop the necessary medical technologies.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"489-503"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice. 组成型一氧化氮合酶缺乏损害环丁烷嘧啶二聚体在细胞和小鼠太阳紫外线照射后的修复。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-08-31 DOI: 10.1111/php.70024

Veronica Bahamondes Lorca, Yuxi Zhou, Christina Athans, Hailey Payne, Madison Wright, Zeinab Feyyaz, Lingying Tong, Dawn L Sammons, Shiyong Wu

{"title":"Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice.","authors":"Veronica Bahamondes Lorca, Yuxi Zhou, Christina Athans, Hailey Payne, Madison Wright, Zeinab Feyyaz, Lingying Tong, Dawn L Sammons, Shiyong Wu","doi":"10.1111/php.70024","DOIUrl":"10.1111/php.70024","url":null,"abstract":"Solar ultraviolet (sUV) radiation is a major environmental factor that induces DNA damage, promoting skin aging and carcinogenesis. The formation of cyclobutane pyrimidine dimers (CPDs) is one of the most prevalent forms of UV-induced DNA lesions, playing a central role in skin photocarcinogenesis. Constitutive nitric oxide synthase (cNOS), responsible for basal nitric oxide (NO˙) production, has been implicated in various cellular processes, including the DNA damage response. However, the role of cNOS in modulating DNA repair post-UV exposure has not been explored. In this study, we investigated the impact of cNOS deficiency on CPD repair following sUV exposure using both in vivo and in vitro models. SKH-1 hairless wild-type and nNOS+/-/eNOS-/- (cNOS-deficient) mice were chronically exposed to sUV, revealing significantly exacerbated skin lesions in cNOS-deficient animals. Primary fibroblasts and skin explants derived from these mice, as well as HEK293 cells with stable cNOS overexpression, were analyzed for CPD formation and repair dynamics. Our findings show that cNOS knockout leads to impaired CPD repair, with CPD levels persisting longer in cNOS-deficient cells and tissues compared with wild-type controls. Reintroduction of cNOS expression in HEK293 cells accelerated CPD clearance early post-sUV exposure, suggesting a protective role for cNOS in the DNA repair process. These results highlight cNOS as a critical modulator of UV-induced DNA damage repair and underscore its potential role in mitigating skin carcinogenesis.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"315-327"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent proteins: A journey from the cell to extreme environments in material science. 荧光蛋白：材料科学中从细胞到极端环境的旅程。

IF 2.5 4区生物学

Photochemistry and Photobiology Pub Date : 2026-03-01 Epub Date: 2025-07-21 DOI: 10.1111/php.70011

Bianca Menchicchi, Andre C Stiel, Mattia Nieddu, J P Fuenzalida-Werner

{"title":"Fluorescent proteins: A journey from the cell to extreme environments in material science.","authors":"Bianca Menchicchi, Andre C Stiel, Mattia Nieddu, J P Fuenzalida-Werner","doi":"10.1111/php.70011","DOIUrl":"10.1111/php.70011","url":null,"abstract":"This review presents the progression from the use of fluorescent proteins (FPs) and chromoproteins as bioimaging labels and sensors to the strategic engineering of their properties for robust functionality in synthetic and non-biological environments. Specifically, engineered variants of the small ultra-red fluorescent protein (smURFP) were developed and optimized for optoacoustic imaging through structure-guided mutagenesis. Reversibly switchable genetically encoded indicators were also created to enhance bioimaging capabilities. To extend the applicability of such proteins to material science and enable their function in everyday applications-such as environmental sensors, encoders, or color components in textiles and electronics-their inherent stability limitations were addressed. For this purpose, supramolecular stabilization strategies, including genetically encoded macro-oligomerization techniques, were explored. These methods effectively enhanced the resilience of FPs under chemically challenging conditions, without compromising their photophysical properties. Finally, the exploration of circularly polarized luminescence (CPL) from FPs is discussed, and their potential as CPL emitters suitable for sustainable photonic applications is identified. Overall, the transformative potential of engineered FPs as essential components for applications beyond bioimaging is emphasized.","PeriodicalId":20133,"journal":{"name":"Photochemistry and Photobiology","volume":" ","pages":"290-302"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0