Plant Foods for Human Nutrition最新文献

{"title":"Phenolic Extracts with Antioxidant and Anticancer Potential from Araticum Fruits (Annona crassiflora Mart.), a Native Brazilian Plant.","authors":"Bingqi Chen, Bruna Tischer, Philipus Pangloli, Vermont P Dia","doi":"10.1007/s11130-025-01383-y","DOIUrl":"10.1007/s11130-025-01383-y","url":null,"abstract":"","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"143"},"PeriodicalIF":3.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Price of Canadian Gluten-Free Staple Foods Remains More than Double and Iron Content Less than Half of Standard Foods in 2024.","authors":"Jennifer A Jamieson, Heather Blewett","doi":"10.1007/s11130-025-01365-0","DOIUrl":"https://doi.org/10.1007/s11130-025-01365-0","url":null,"abstract":"","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"141"},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic Properties of Anthocyanin and Protein Extracts from Sweet Potatoes (Ipomoea batatas L.): Effect of Enzymatic Inactivation Treatments.","authors":"Ana Clara Troya Raineri Fiocco, Ana Carla Kawazoe Sato, Carolina Siqueira Franco Picone, Marcelo Alejandro Alarcón Lozano","doi":"10.1007/s11130-025-01371-2","DOIUrl":"10.1007/s11130-025-01371-2","url":null,"abstract":"<p><p>Cardiovascular diseases are a leading cause of death worldwide, with thrombosis playing a major role. Synthetic antithrombotic therapies often have adverse effects, highlighting the need for safer, natural alternatives. This study investigates the antithrombotic potential (antiplatelet and anticoagulant activities) and hemocompatibility of protein and anthocyanin extracts from sweet potato byproducts. Since polyphenol oxidase (PPO) can impact on the biological activity of these extracts, treatments to inactivate PPO were applied with ascorbic acid immersion and bleaching. Anthocyanin extract (1 mg/mL) inhibited platelet aggregation induced by ADP, collagen, and PMA. Both anthocyanin and protein extract prolonged coagulation times (aPTT, thrombin time, and fibrinogen assay) and exhibited no toxicity in hemolysis and cytotoxicity analyses. Additionally, anthocyanins reduced key platelet activation markers (P-selectin, CD63, fibrinogen). Ascorbic acid pre-treatment against PPO enhanced the biological activity of anthocyanins. This study demonstrates that sweet potato anthocyanins and proteins possess significant antithrombotic properties, offering potential as sustainable, natural alternatives to synthetic thrombosis treatments. Further studies are needed to explore their bioavailability, in vivo effects, and clinical applications.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"142"},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Red Yeast Rice in the Improvement of Atherosclerosis in Apolipoprotein E-deficient Mice Explored Through Metabolomics Combined with Serum Pharmacochemistry and Network Pharmacology.","authors":"Yanyan Zhang, Dongju Ren, Yu Liu, Na Li, Xiaoli Yang, Shufang Yang, Rongxia Liu","doi":"10.1007/s11130-025-01379-8","DOIUrl":"https://doi.org/10.1007/s11130-025-01379-8","url":null,"abstract":"<p><p>Red Yeast Rice (RYR), the fermentation of cooked rice kernels with Monascus purpureus, has been traditionally and increasingly applied to alleviate atherosclerosis (AS). Nonetheless, the precise mechanisms underlying its therapeutic effects in AS treatment remain elusive. Metabolomics combined with serum pharmacochemistry and network pharmacology was utilized to explore the potential molecular mechanisms by which RYR improves AS. RYR showed a significant inhibitory effect on metabolic dysfunction in mice. Specifically, through metabolomics analysis, 45 metabolic biomarkers were identified, which are associated with 5 metabolic pathways, particularly arachidonic acid metabolism. Serum pharmacochemistry identified 11 absorbed constituents of RYR that entered the bloodstream. Subsequent correlation analysis determined that 10 constituents may serve as bioactive ingredients significantly associated with the metabolic biomarkers. Network pharmacology identified 5 core targets and enriched 129 representative pathways, among which the PI3K/AKT signaling pathway received the highest score. Molecular docking verified that there existed strong binding energy between the absorbable components and pivotal targets. The pharmacodynamic evaluation results verified that the down-regulation of PI3K and p-AKT expressions in the PI3K/AKT pathway served as the underlying mechanism of RYR in addressing AS. These findings underscore the pharmacodynamic components, pivotal targets, and pathways of RYR in AS treatment, as well as the development of functional foods involving RYR.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"140"},"PeriodicalIF":3.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cynarin Counteracts Lipotoxicity in Pancreatic β-Cells Via Inhibiting Palmitate-Induced Apoptosis and Linoleic Acid-Provoked Ferroptosis.","authors":"Ning Wang, Jun Wang, Yifei Wu, Minglan Qu, Junwen Hong, Zhaoyuan Cui, Yinuo Chen, Rui Zhang","doi":"10.1007/s11130-025-01382-z","DOIUrl":"https://doi.org/10.1007/s11130-025-01382-z","url":null,"abstract":"<p><p>Lipotoxicity has raised intense public concerns for its cytotoxicity and associated chronic diseases. Pancreatic β-cells are highly susceptible to lipotoxicity, since the excessive lipids may produce massive reactive oxygen species (ROS), cause severe oxidative stress, induce the dysfunction of endoplasmic reticulum (ER), damage lipid membranes and trigger the eventual cell death. This study explored the mechanism of cynarine (CYN) in preventing rat pancreatic cells (RINm5F) from the cytotoxicity induced by representative fatty acids, palmitate (PA, physiologically abundant) and linoleic acid (LA, prevalent in Western-style diets). In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, CYN administration significantly enhanced the viability of pancreatic β cells exposed to PA or LA, validating its protective efficacy against lipotoxicity in RINm5F cells. Further experiments demonstrated that CYN treatment prevented PA-treated beta cells from apoptosis by quenching the intracellular ROS, ameliorating the cellular damages of lipid peroxidation, mitigating cellular calcium dysregulation, suppressing crucial ER stress mediator proteins' expression, attenuating aberrant sub-G1 cell population, and inhibiting the expression of key proapoptotic proteins. In the β cells stressed by LA, CYN treatment efficiently abrogated the abnormal elevation of cellular ferric iron content, inhibited lipid peroxidation, improved the declined GSH content, enhanced the expression of glutathione peroxidase 4, and thereby alleviated the LA-provoked ferroptosis. The findings provide experimental evidence for employing CYN as a preferential antagonist to intervene in lipotoxicity and relevant diseases like diabetes mellitus.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"139"},"PeriodicalIF":3.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeinated and Decaffeinated Yerba Mate (Ilex paraguariensis) Infusion Extracts Alter CD73 and Reduce the Migration and Adhesion of Glioblastoma Cells.","authors":"Dimitryus Rodrigues Birkhan, Rafael Diogo Weimer, Fernando Mendonça Diz, Leticia de Leon Aguiar, Vinicius Padilha Pedroso, Vitor Justo Pereira, Gabriela Santos Rocha, Eduardo Luiz Pedrazza, Stefan Laufer, Bruna Sgarioni, Victor Hugo Silva Rodrigues, Eduardo Cassel, Fernanda Bueno Morrone","doi":"10.1007/s11130-025-01375-y","DOIUrl":"https://doi.org/10.1007/s11130-025-01375-y","url":null,"abstract":"<p><p>Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasiveness. Treatment remains challenging due to their immunomodulatory properties, which promote immune evasion and tumor progression. Given the substantial consumption of yerba mate in the southern hemisphere, this study evaluated the effects of caffeinated and decaffeinated yerba mate infusion extracts (ECaf and EDCaf, respectively) on glioblastoma cell lines (U87 and U251). Both extracts reduced cell viability in a dose-dependent manner, with U87 being more sensitive. ECaf and EDCaf inhibited cell migration and adhesion, particularly in U87 cells. Real-time PCR showed a reduction in CD73 and MMP2 expression in U87, whereas U251 exhibited a slight increase in MMP2 expression. CD73 enzymatic activity was reduced in U87 cells by both extracts but remained unaffected in U251 cells. Overall, the results suggest that caffeine absence does not alter the bioactivity of yerba mate extracts, highlighting their potential to modulate glioblastoma cell behavior.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"137"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Storage on Bioactive and Toxic Compounds in Jicama (Pachyrhizus erosus) Tubers: Effects on Thyroid Cancer and Inflammatory Responses.","authors":"Paweł Paśko, Agnieszka Galanty, Marta Markiewicz, Efren Delgado, Aleksandra Capik, Octavio Paredes-Lopez, Shela Gorinstein","doi":"10.1007/s11130-025-01381-0","DOIUrl":"10.1007/s11130-025-01381-0","url":null,"abstract":"<p><strong>Background: </strong>Jicama (Pachyrhizus erosus) tubers contain isoflavones and phenolic acids with potential chemopreventive and anti-inflammatory effects. This study analyzed bioactive and toxic compounds in fresh jicama tuber (flesh and peel) and assessed changes during freezing for 3 and 4 months. Antioxidant, cytotoxic, and anti-inflammatory effects were evaluated on human thyroid cancer (FTC133, 8505 C, TPC1), and normal cells (Nthy-ori 3 - 1), and RAW 264.7 macrophages.</p><p><strong>Methods: </strong>High-performance liquid chromatography (HPLC) identified active compounds. Antioxidant activity was tested using FRAP and DPPH assays. Cytotoxicity was evaluated using the MTT assay, while anti-inflammatory effects were measured via TNF-α, IL-6 (ELISA), and nitric oxide levels (Griess assay).</p><p><strong>Results: </strong>Fresh peel contained the highest levels of isoflavones (mg/100 g dry weight) - biochanin A; 52.5, daidzein; 23.0, genistein; 2.6) and phenolic acids (chlorogenic; 61.7, isochlorogenic acids; 95.8), which declined significantly after freezing. No rotenone was detected. Peel extracts exhibited the strongest cytotoxicity against thyroid cancer cells, particularly FTC133, showing dose-dependent inhibition of cell viability. However, they also exhibited cytotoxicity against normal thyroid cells, highlighting potential risks. Flesh extracts showed weaker cytotoxic effects but demonstrated slightly stronger anti-inflammatory activity than peel extracts. Both extracts effectively reduced TNF-α, IL-6, and nitric oxide levels in RAW 264.7 macrophages. Storage time during freezing had no significant impact on anti-inflammatory activity or cytotoxic potency, but it significantly reduced antioxidant activity.</p><p><strong>Conclusion: </strong>Jicama peel is richer in bioactive compounds than the flesh and exhibits strong cytotoxic effects on thyroid cancer cells, although it also affects normal cells. Freezing reduces phytonutrient content and antioxidant potential but does not alter anti-inflammatory efficacy.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"138"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CsCCD2L is Involved in the Response to Light Stress by Regulating Zeaxanthin Content in Saffron (Crocus sativus L.).","authors":"Xiaoyuan Xi, Jia Song, Mengqing Feng, Jing Li, Liqin Li","doi":"10.1007/s11130-025-01376-x","DOIUrl":"10.1007/s11130-025-01376-x","url":null,"abstract":"<p><p>Saffron, a plant flowering in fall and prized for its medicinal red stigmas, has a unique life cycle. After dormancy, the flower formation process starts from late summer to fall. Post-harvest, it enters the vegetative growth stage from winter to spring. The reason behind its growth pattern remains unknown. In our study, we found that overexpressing carotenoid cleavage dioxygenase 2 (CsCCD2L, a long transcript of CsCCD2) in Arabidopsis thaliana affected the content of zeaxanthin and light tolerance. In saffron, CsCCD2L varies throughout its life cycle, impacting zeaxanthin content. Saffron flowers indoors with its leaves still enclosed in sheathing cataphylls. The expression of CsCCD2L in saffron leaves reached its peak on the day of anthesis, but significantly decreased in the vegetative stage when leaves extend from the sheathing cataphylls for photosynthesis. Intense light during this stage leads to leaf yellowing, a reduction in CsCCD2L expression, and an increase in zeaxanthin content. These results indicate that CsCCD2L regulates the content of zeaxanthin and light tolerance. Moreover, CsCCD2L exhibited the highest expression in the orange stigmas. Subjecting flower buds at the orange stigma stage to intense light significantly reduced the crocin content in mature stigmas. Collectively, these results not only shed light on the unique growth pattern of saffron but also offer promising avenues for enhancing saffron quality through the precise manipulation of light intensity and the expression of CsCCD2L.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"136"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Postharvest Quality and Antioxidant Properties of Mango Using Cinnamic Acid-Enriched Xanthan Gum Coatings.","authors":"Ajay Kamboj, Pps Gill, S K Jawandha, Nav Prem Singh, Rachna Arora, Arashdeep Singh, Preetinder Kaur","doi":"10.1007/s11130-025-01380-1","DOIUrl":"https://doi.org/10.1007/s11130-025-01380-1","url":null,"abstract":"","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"135"},"PeriodicalIF":3.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Extraction and Microencapsulation for Increasing Stability of Anthocyanins Extracted from Purple Sweet Potato.","authors":"Sandra Vega-Maturino, Luz Araceli Ochoa-Martínez, Silvia Marina González-Herrera, Olga Miriam Rutiaga-Quiñones, Azucena Rodríguez-Mena","doi":"10.1007/s11130-025-01378-9","DOIUrl":"https://doi.org/10.1007/s11130-025-01378-9","url":null,"abstract":"<p><p>The purple sweet potato is an adaptable and fast-growing crop that thrives in various soil conditions, making it efficient and accessible. Its high post-harvest durability and elevated anthocyanin content (≈ 1202.70 mg cya-3-glu/100 g w.b.) make it a promising source of natural pigments. However, anthocyanins are unstable due to physical and environmental factors, limiting their application. This study evaluated the stability of anthocyanins extracted from purple sweet potato using ultrasound for 4, 6, 8, and 10 min and amplitudes of 20, 40, 60, and 80%, and their microencapsulation by spray drying with maltodextrin. The microencapsulation efficiency was 81.93%. The infrared spectroscopy analysis confirmed the protection of the extract, while calorimetric analysis demonstrated its thermal stability. After two months of storage in the dark at room temperature (22-25 °C), 67.47% retention of anthocyanins was achieved, with a t_1/2 of 99.88 days. Physicochemical and rehydration properties of the microencapsulated were maintained over two months of storage. The results suggest that microencapsulation significantly improves the stability of purple sweet potato anthocyanin extract, offering a natural colorant with potential for the food industry.</p>","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 3","pages":"134"},"PeriodicalIF":3.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}