Plant Foods for Human Nutrition最新文献_第2页

Unlocking the Potential of Chia Intake in the Management of Metabolic Syndrome and its Risk Conditions: A Narrative Review.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-18 DOI: 10.1007/s11130-025-01331-w

Mariana Buranelo Egea, Sibele Santos Fernandes

{"title":"Unlocking the Potential of Chia Intake in the Management of Metabolic Syndrome and its Risk Conditions: A Narrative Review.","authors":"Mariana Buranelo Egea, Sibele Santos Fernandes","doi":"10.1007/s11130-025-01331-w","DOIUrl":"https://doi.org/10.1007/s11130-025-01331-w","url":null,"abstract":"Metabolic syndrome is the occurrence of at least three of the five conditions diabetes, overweight and obesity, triglyceridemia, hypercholesterolemia, and hypertension. Dietary interventions have been one of the first lines of treatment indicated for improving conditions related to metabolic syndrome. The growing interest in plant-based diets and foods with health-promoting qualities has increased significantly. Due to its excellent nutritional and bioactive value, chia seeds have a significant market share, characterized by their high content of proteins, essential fatty acids, fiber, vitamins, minerals, phenolic compounds, and antioxidants. These constituents promote potential positive effects on improving health, especially blood pressure, and reducing oxidative stress and the inflammatory state installed by metabolic syndrome and its risk conditions. However, the ten studies in humans that were reviewed generally showed no effect on anthropometric parameters and biochemical parameters related to glucose and lipid homeostasis. Thus, although chia seeds have a high potential to combat metabolic syndrome, this review found few studies, highlighting a gap in the area and a possible future topic for researchers.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 2","pages":"90"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Sunlight Exposure and Traditional Dehydration on Chemical and Nutritional Properties of Oxalis tuberosa (oca) Tubers.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-18 DOI: 10.1007/s11130-025-01330-x

Grover Castañeta, Daniela Miranda-Flores, Atma-Sol Bustos, Rocio García, Erick Loayza, Cristhian Carrasco, Leslie Tejeda, Franco M Cabrerizo, J Mauricio Peñarrieta

{"title":"Influence of Sunlight Exposure and Traditional Dehydration on Chemical and Nutritional Properties of Oxalis tuberosa (oca) Tubers.","authors":"Grover Castañeta, Daniela Miranda-Flores, Atma-Sol Bustos, Rocio García, Erick Loayza, Cristhian Carrasco, Leslie Tejeda, Franco M Cabrerizo, J Mauricio Peñarrieta","doi":"10.1007/s11130-025-01330-x","DOIUrl":"https://doi.org/10.1007/s11130-025-01330-x","url":null,"abstract":"Oca (Oxalis tuberosa), a potato like crops, is cultivated extensively in the high altitude regions of the Andes. Traditionally, consumers have used sunlight to enhance the sweetness of oca and have used methods to produce a dehydrated product known as 'khaya' for its preservation. This research seeks to assess the chemical and nutritional changes that four oca cultivars undergo after exposure to sunlight and traditional dehydration techniques. The results of the study indicate that exposure of freshly harvested oca to sunlight contributes to antioxidant capacity, increased concentration of polyphenols, carotenoids and polyunsaturated fatty acids, and an overall improvement in nutritional properties characterized by a reduction in oxalate content and a significant increase in sugar concentration. On the other hand, dehydration byproducts are associated with a decrease in antioxidant capacity and polyphenols, a reduction in oxalate content and is accompanied by an increase in amylopectin. The changes in sugar content depend on the specific dehydration treatment used. Taken together, these results suggest that exposure of oca to sunlight not only improves its chemical and nutritional profile, but also contributes to an overall improvement in quality. On the other hand, dehydration of oca serves as a preservation technique, extending its shelf life while maintaining certain nutritional properties. This research provides valuable insights into optimizing the post-harvest handling of oca to improve quality and prolong shelf life.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 2","pages":"91"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-Based Chocolate Desserts: Analysis of Consumer's Response According to Sensory Properties of Products and Consumer Attitude Towards Meat Reduction.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-18 DOI: 10.1007/s11130-025-01338-3

Franco D Della Fontana, Gabriel López-Font, Djemaa Moussaoui, María C Goldner, Carolina Chaya

{"title":"Plant-Based Chocolate Desserts: Analysis of Consumer's Response According to Sensory Properties of Products and Consumer Attitude Towards Meat Reduction.","authors":"Franco D Della Fontana, Gabriel López-Font, Djemaa Moussaoui, María C Goldner, Carolina Chaya","doi":"10.1007/s11130-025-01338-3","DOIUrl":"10.1007/s11130-025-01338-3","url":null,"abstract":"Brea gum is a food additive with potential for economic and environmental sustainability. It may be used in plant-based formulations, such as chocolate desserts, but achieving acceptable sensory characteristics remains a challenge. Therefore, the aim was to compare the response of consumers to two plant-based chocolate desserts, under blind and informed conditions about ingredient formulation. Two plant-based chocolate desserts were used: one made with Brea gum and black carob flour (BG) and a commercial soy chocolate dessert (CS). Eight trained judges characterized the sensory properties of both products. 103 consumers (female = 62, aged between 18 and 45) tasted both products in blind and informed conditions and rated their overall liking, and their liking of appearance, odour, texture, sweetness, flavour, and vegetable aftertaste. Purchase intention and healthy, processed and sustainable perception were also rated. Participants also completed a questionnaire on attitudes towards reducing meat consumption. BG samples showed higher intensities of vegetable odour and vegetable aftertaste, while CS samples were significantly higher in sweetness and brown colour (p < 0.05). Acceptability was significantly higher in CS than in BG (7.1 ± 1.6 and 4.9 ± 2.2, respectively, p < 0.05). BG was perceived as more sustainable than CS (6.6 ± 2.3, 6.1 ± 2.2, respectively; p < 0.05). Information about the samples had no effect on overall liking. Supporters of meat reduction showed a higher acceptability for both desserts than rejecters. Acceptability of both plant-based desserts was influenced by intrinsic sensory characteristics and by consumers' attitude towards meat reduction. Improvements in sensory attributes need further development.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 2","pages":"93"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eucommia folium can be Prepared as a Tea with the Ability to Prevent and Treat Hyperuricaemia. 杜仲叶可以泡茶喝，具有预防和治疗高尿酸血症的功效。

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-18 DOI: 10.1007/s11130-025-01332-9

Qing Hao, Ying Liu, Zikun Zhai, Bo Wang, Lin Jiang, Qiyun Zhang, Jiawei Su, Maiting Zhang, Jiajun Li, Shuo Chen, Ziyun Ye, Qiusheng Zheng, Xiangcheng Fan, Jichun Han

{"title":"Eucommia folium can be Prepared as a Tea with the Ability to Prevent and Treat Hyperuricaemia.","authors":"Qing Hao, Ying Liu, Zikun Zhai, Bo Wang, Lin Jiang, Qiyun Zhang, Jiawei Su, Maiting Zhang, Jiajun Li, Shuo Chen, Ziyun Ye, Qiusheng Zheng, Xiangcheng Fan, Jichun Han","doi":"10.1007/s11130-025-01332-9","DOIUrl":"https://doi.org/10.1007/s11130-025-01332-9","url":null,"abstract":"The aim of this study was to investigate the antihyperuricaemic (HUA) effect of Eucommia folium after preparing a tea made from its leaves (abbreviated as DZ) which has the ability to prevent and treat HUA. In this study, a mouse HUA model was established via gavage of potassium oxonate and hypoxanthine, and this HUA model was treated with DZ to investigate the therapeutic effect of DZ on HUA. This study recruited 30 HUA volunteers, who drank 10 g of DZ daily for four consecutive weeks. The serum HUA levels of UA volunteers were measured once per week to observe the anti-HUA efficacy of DZ at the clinical level. Animal experiments have shown that DZ has therapeutic effects on HUA. DZ effectively reduces the levels of uric acid (UA), creatinine (Cr), and urea nitrogen (BUN) in the serum of HUA mice; decreases xanthine oxidase (XOD) activity in the serum; and alleviates damage to kidney tissues and glomeruli. Metabolomic analysis revealed that DZ affects multiple metabolites, such as orotidine, orotic acid, ureidosuccinic acid, 1-methylhistidine, and other metabolites, and these metabolites are involved mainly in pyrimidine metabolism, histidine metabolism, and riboflavin metabolism. Clinical research revealed that, after DZ was consumed, the UA levels in the HUA volunteers significantly decreased. Our research findings suggest that DZ may have a protective effect against HUA. and is in the same class of traditional Chinese medicines used in medicine and food, with extremely low toxicity and high safety. Therefore, DZ may be suitable for preparation as a functional food with anti HUA effects. CLINICAL TRIAL NUMBER: Not applicable.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 2","pages":"92"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory Properties, Textural Analysis, and Some Physical Analysis of Enriched Extruded Products Produced from Different Grain Products.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-18 DOI: 10.1007/s11130-025-01336-5

Hayriye Genç, Nizam Mustafa Nizamlıoğlu

{"title":"Sensory Properties, Textural Analysis, and Some Physical Analysis of Enriched Extruded Products Produced from Different Grain Products.","authors":"Hayriye Genç, Nizam Mustafa Nizamlıoğlu","doi":"10.1007/s11130-025-01336-5","DOIUrl":"10.1007/s11130-025-01336-5","url":null,"abstract":"A functional product has been produced from a mixture of whole wheat flour and corn semolina, which can be consumed as a healthy snack compared to oily and additive-laden chip products. Extruded products were obtained at various output die temperatures (130, 150, and 170 °C) in a twin-screw extruder from mixtures prepared with different raw material humidity (12, 14, and 16%) from the mixtures of whole wheat flour, corn semolina, and D-glucose. The water binding capacity increased with increasing raw material humidity and output die temperature. Expansion index value was founded corn semolina had the highest value (3.11 ± 0.22), whereas whole wheat flour with D-glucose added had the lowest value (2.10 ± 0.34). Through sensory investigation, the most popular product groupings were determined to be whole wheat flour and corn semolina-extruded products. It is expected that this study will be able to produce extruded products from whole wheat flour and corn semolina and will set an example for the development of new functional products.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 2","pages":"94"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Therapeutic Potential of Smilax perfoliata and Elsholtzia griffithii Through GC-MS Analysis, Antimicrobial Assay and Molecular Docking.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-11 DOI: 10.1007/s11130-025-01335-6

Anwesha Chatterjee, Aritra Palodhi, Heera Basnet, Payal Agarwal, Bijan K Das, Chittabrata Mal, Harshata Pal

{"title":"Understanding the Therapeutic Potential of Smilax perfoliata and Elsholtzia griffithii Through GC-MS Analysis, Antimicrobial Assay and Molecular Docking.","authors":"Anwesha Chatterjee, Aritra Palodhi, Heera Basnet, Payal Agarwal, Bijan K Das, Chittabrata Mal, Harshata Pal","doi":"10.1007/s11130-025-01335-6","DOIUrl":"https://doi.org/10.1007/s11130-025-01335-6","url":null,"abstract":"Herbalism, rooted in traditional knowledge and regional practices, leverages plants as medicinal resources. India, with its vast biodiversity, harbors numerous untapped medicinal plants. This study focuses on the bioprospecting of two underexplored wild medicinal plants, Elsholtzia griffithii from Manipur and Smilax perfoliata from West Bengal, aiming to document their medicinal potential. We characterized metabolites in their crude methanolic extracts and explored their resistance to bacterial infections. Utilizing gas chromatography-mass spectrometry (GC-MS) analysis, 17 significant chemical compounds are identified, exhibiting physiological and pharmacological importance. Conducting disc-diffusion assays against E. coli, both plant extracts demonstrate antibacterial activity. Crude methanolic extracts of Smilax perfoliata and Elsholtzia griffithii showed a zone of inhibition of approximately 13 mm and 4 mm respectively. Additionally, molecular docking studies were conducted to evaluate the binding energy of the compounds to the E. coli receptors, DNA GyrB, and FabH and identify the receptor-ligand interactions. Among them, 4-Dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine and Phthalic acid, dodecyl 2-methoxyethyl ester from Smilax perfoliata, and p-(dimethyl amino) benzaldehyde pyridine-4-carbonyl hydrazone from Elsholzia griffithii exhibit lower binding energy. The interactions between these 3 compounds and the receptors consisted of hydrogen bonding and hydrophobic interactions. Thus, it underscores the potential of compounds derived from these plants as inhibitors against gram-negative bacteria. Thus, our study unveils the ethnomedicinal properties of these wild plants, providing a comprehensive metabolite profile and paving the way for potential drug discovery.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 2","pages":"89"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Morphogenetic and Diurnal Variability in Phenolic and Flavonoid Content of Echinacea purpurea (L.) Moench: A Potential Source of Natural Anioxidants.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-10 DOI: 10.1007/s11130-025-01315-w

Bilge Ozcan, Nejdet Sen, Mustafa Resul Demiray, Ibrahim Bulduk, Ercument Osman Sarihan, Mehmet Ugur Yildirim

{"title":"Determination of Morphogenetic and Diurnal Variability in Phenolic and Flavonoid Content of Echinacea purpurea (L.) Moench: A Potential Source of Natural Anioxidants.","authors":"Bilge Ozcan, Nejdet Sen, Mustafa Resul Demiray, Ibrahim Bulduk, Ercument Osman Sarihan, Mehmet Ugur Yildirim","doi":"10.1007/s11130-025-01315-w","DOIUrl":"10.1007/s11130-025-01315-w","url":null,"abstract":"Echinacea purpurea (L.) Monech has a diverse range of phytochemicals, including flavonoids, polyphenols, phenolic acids, alkylamides, and terpenoids. Phenolic and flavonoid substances derived from the leaves and flowers have been used for treatment of illness. The aim of this study to evaluate the polyphenolic components of the flowers and leaves of E. purpurea, along with the diurnal variations and the morphological differences. Two-year-old in full bloom flowers and leaves were harvested at different times of the day (6:00 am, 9:00 am, 12:00 am, 03:00 pm, 06:00 pm, 09:00 pm). The water and methanol extracts prepared from these samples to determine total phenolic, total flavonoid and phenolic compound contents. The experiment was established in randomized complete block design with three factors and three replications. The highest total phenolic content was observed in flowers with methanol extract (157.91 ± 0.32 mg QE/g dry extract) at 09.00 a.m. Also the highest total flavonoid content was observed in leaves with methanol extract at 09.00 a.m (80.12 ± 0.16 mg QE/g dry extract). Chlorogenic acid (19.1 ± 0.83 mg/g methanol extract) and caffeic acid (13.2 ± 0.58 mg/g methanol extract) were identified as the predominant phenolic acids. The peak concentrations of these phenolic acids were observed at 6:00 a.m, followed by a gradual decline throughout the subsequent hours of the day. Findings emphasize the importance of harvesting E. purpurea at the optimal time to maximize antioxidant capacity. This study provides valuable new information on morphogenetic and diurnal variation of phenolic and flavonoid content for drug and pharmaceutical raw material production.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 1","pages":"88"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic and Antioxidant Molecules of Ficus tikoua and their Combined Effect: Bioassay-Guided Isolation, In Vitro and In Silico Analysis.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-07 DOI: 10.1007/s11130-025-01329-4

Hanlei Wang, Jing Lu, Xuelin Chen, Kun Zhang, Xia Zhao, Yumei Zhang

{"title":"Antidiabetic and Antioxidant Molecules of Ficus tikoua and their Combined Effect: Bioassay-Guided Isolation, In Vitro and In Silico Analysis.","authors":"Hanlei Wang, Jing Lu, Xuelin Chen, Kun Zhang, Xia Zhao, Yumei Zhang","doi":"10.1007/s11130-025-01329-4","DOIUrl":"10.1007/s11130-025-01329-4","url":null,"abstract":"Ficus tikoua has high medicinal and edible value. Our previous study had demonstrated its antidiabetic properties, but the specific active molecules and their mechanisms remained unclear. In this study, five active compounds, namely marmesin glycoside (1), quercetin (2), quercetin 3-O-β-D-glucuronide-6''-methyl ester (3), (-)-epicatechin (4), (+)-epicatechin (5), were isolated by bioassay-guided method and identified. Compounds 1-5 displayed varying degrees of efficacy (IC50 = 3.80-79.58 μM) and affinity (6.3-7.7 kcal/mol) on α-glucosidase. This was the first report that compound 1 exhibited the significant inhibitory activity on α-glucosidase (IC50 = 3.80 μM) through a mixed inhibition mode, engaging with the residues GLY228 and ASN301. Additionally, compounds 1 and 2 showed the effect on promoting glucose uptake in 3T3-L1 adipocytes. Compounds 2-5 all showed potent effects in DPPH, ABTS, FRAP and DNA oxidative damage assays. Among them, compound 5 exhibited the strongest antioxidant activity for DPPH, ABTS, FRAP (10.56 μM, 4.34 mol Trolox/mol and 1.54 mol Trolox/mol, respectively), and compounds 3 and 5 (4 μM) demonstrated potent DNA protective effect. When combined in binary form, compounds 1 and 4 (FICI = 0.23), and compounds 4 and 5 (FICI = 0.47) displayed synergistic effects. This study revealed that Ficus tikoua could be used as a functional food, and the active compounds and combinations could serve as complementary therapeutic strategies for diabetes.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 1","pages":"87"},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Cytotoxic and NO Inhibitory Potential of Heliotropium dolosum Extracts from Türkiye: A First Insight Into Its Phenolic Profile.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-06 DOI: 10.1007/s11130-025-01313-y

Cennet Özay

{"title":"Unveiling the Cytotoxic and NO Inhibitory Potential of Heliotropium dolosum Extracts from Türkiye: A First Insight Into Its Phenolic Profile.","authors":"Cennet Özay","doi":"10.1007/s11130-025-01313-y","DOIUrl":"10.1007/s11130-025-01313-y","url":null,"abstract":"Heliotropium dolosum (Boraginaceae) is traditionally used for its choleretic, antipyretic, and cicatrizing properties. Despite some reports on its traditional uses, this species' cytotoxic and nitric oxide (NO) inhibitory potential and its polyphenolic compounds have not been previously investigated. This study aims to evaluate the antioxidant, cytotoxic, and NO inhibitory activities of H. dolosum extracts and to identify polyphenolic compounds that could be contributing to these effects. The antioxidant activity of H. dolosum extracts (ethanol, methanol, chloroform, water) was assessed using six in vitro models. Total phenolics, flavonoids, and saponins were quantified via colorimetric assays, while phenolic compounds were identified using HPLC. Cytotoxicity was evaluated through brine shrimp lethality and cancer cell assays, and NO inhibitory activity was measured in LPS-induced cancer cells. The methanol extract displayed the highest antioxidant activity, with major phenolic compounds identified as caffeic acid, 2,5-dihydroxybenzoic acid, and ellagic acid with 12.307, 5.710 and 5.061 mg/g, respectively. It showed notable cytotoxicity (LC₅₀ = 18.1 µg/mL) and concentration-dependent effects on cancer cells. The highest NO inhibition was observed in HCC78 cells (15.56 µM nitrite). H. dolosum demonstrates potential as a wild plant source of bioactive compounds with antioxidant, cytotoxic, and NO inhibitory properties, highlighting its promise for functional food development and nutraceutical applications.","PeriodicalId":20092,"journal":{"name":"Plant Foods for Human Nutrition","volume":"80 1","pages":"86"},"PeriodicalIF":3.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pea Peptides and Heavy Metal Neurotoxicity: Exploring Mechanisms and Mitigation Strategies in PC12 Cells.

IF 3.1 2区农林科学

Plant Foods for Human Nutrition Pub Date : 2025-03-04 DOI: 10.1007/s11130-025-01322-x

Ning Li, Ningning Cui, Tiange Li, Peijun Zhao, Ibrahim A Bakry, Qian Li, Yongxia Cheng, Gianni Galaverna, Huijie Yang, Fangyu Wang

引用次数: 0