Physiological Reports最新文献_第6页

The effect of nandrolone decanoate administration on fatigue during a volume-overload stress in male mice. 癸酸诺龙给药对雄性小鼠容量超负荷应激时疲劳的影响。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70334

Tavor Ben-Zeev, David D Church, Chagai Levi, Inbal Weissman, Abby Fulbright, Avidan Shalev, Ariel Levin, Doron Schussheim, Arny A Ferrando, Jay R Hoffman

{"title":"The effect of nandrolone decanoate administration on fatigue during a volume-overload stress in male mice.","authors":"Tavor Ben-Zeev, David D Church, Chagai Levi, Inbal Weissman, Abby Fulbright, Avidan Shalev, Ariel Levin, Doron Schussheim, Arny A Ferrando, Jay R Hoffman","doi":"10.14814/phy2.70334","DOIUrl":"https://doi.org/10.14814/phy2.70334","url":null,"abstract":"The effect of nandrolone decanoate on fatigue was examined during a volume-overload training stress in 3-month-old male C57Bl/6J mice (n = 24). Mice were randomized into two exercising groups and a control group (C). The exercising animals performed a 3-day per week resistance training program for 3 weeks. Exercising animals were further randomized into an androgen group (RTA) or a sham group (RTS). To exert a volume-overload, the frequency of training was increased to six consecutive days during week 4. RTA received a supraphysiological dose of nandrolone decanoate (38-mg·kg-1) before and after the volume-overload week. RTS and C received sham injections. Four mice in RTS were determined to be fatigued, while no mice in RTA were fatigued. TNF-α expression in the plantaris was significantly lower for RTA compared to RTS. Significant elevations in oxidative stress were noted in RTS compared to C in the plantaris, but no differences were noted between RTA and C, suggesting a lower oxidative stress response from nandrolone decanoate administration. Glucocorticoid expression was significantly lower in the soleus of RTA compared to RTS, suggesting a lower catabolic response to the volume-overload stress. In conclusion, nandrolone decanoate intervention attenuated fatigue in animals during a volume-overload stress.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 9","pages":"e70334"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kaempferol ingestion lowers oxygen uptake during submaximal exercise and improves high-intensity exercise capacity in well-trained male athletes. 急性山奈酚摄入降低了亚极限运动时的摄氧量，提高了训练有素的男性运动员的高强度运动能力。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70369

Koichi Okita, Tsubasa Mizokami, Osamu Yasuda, Yasutaka Ikeda

{"title":"Acute kaempferol ingestion lowers oxygen uptake during submaximal exercise and improves high-intensity exercise capacity in well-trained male athletes.","authors":"Koichi Okita, Tsubasa Mizokami, Osamu Yasuda, Yasutaka Ikeda","doi":"10.14814/phy2.70369","DOIUrl":"10.14814/phy2.70369","url":null,"abstract":"Our previous study involving 314 highland crop species demonstrated that kaempferol, a flavonoid present in higher amounts in these species, significantly enhances mitochondrial metabolism and cellular ATP production in myoblasts under limited oxygen conditions. Notably, biologically active substances in these plants, such as phytochemicals, may help improve the health and physical strength of highland residents. Therefore, we hypothesized that kaempferol would affect oxygen availability during exercise and exercise performance in vivo. This randomized, double-blind, placebo-controlled crossover study aimed to assess the effect of a single kaempferol intake (10 mg) on cardiopulmonary response during submaximal exercises (25%, 50%, and 75% VO2max) and maximal and super-maximal endurance capacities (100% and 125% VO2max) in 16 well-trained male university athletes using constant-load exercise tests (VO2max 57.5 ± 5.4 mL·kg-1 min-1). Kaempferol significantly reduced the VO2 and respiratory rate during 25%, 50%, and 75% VO2max exercises (p < 0.05 vs. placebo) without elevating the respiratory quotient and blood lactate. It also significantly increased the exercise duration at 100% VO2max (p < 0.05 vs. placebo). Overall, we demonstrated for the first time that a single intake of kaempferol could reduce oxygen uptake (demand/cost) during constant-load submaximal exercise and extend time-to-exhaustion during maximal exercise. UMIN Clinical Trials Registry in Japan: UMIN000049589.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 9","pages":"e70369"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate variability and overtraining in soccer players: A systematic review. 足球运动员的心率变异性和过度训练：一项系统综述。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70357

Antoine Lipka, Chloé Luthardt, Teddy Tognaccioli, Beatrice Cairo, Raphael Martins de Abreu

{"title":"Heart rate variability and overtraining in soccer players: A systematic review.","authors":"Antoine Lipka, Chloé Luthardt, Teddy Tognaccioli, Beatrice Cairo, Raphael Martins de Abreu","doi":"10.14814/phy2.70357","DOIUrl":"10.14814/phy2.70357","url":null,"abstract":"This systematic review aims to determine if there is a correlation between heart rate variability (HRV) indices and overtraining symptoms (OTS) in soccer players. Conforming to PRISMA guidelines, a search was conducted in February 2024 on Web of Science, PubMed, EMBASE, CINAHL, and SCOPUS. Studies published in English investigating the relationship between HRV parameters and OTS in adult soccer players (>18 years) were included. Accepted study designs were randomized controlled trials, controlled clinical trials, longitudinal studies, prospective studies, cross-sectional studies, and retrospective studies. Methodological quality was assessed using the Joanna Briggs Institute (JBI) checklist. The search identified 2041 articles, with 19 included postscreening. Most studies examined the correlation between HRV and OTS using linear indices. The average JBI checklist score was 6.3, indicating fair methodological quality. Thirteen studies showed a relationship between linear HRV parameters and OTS, linked to performance/clinical tests, training load, adaptation, fatigue, recovery, or hormonal markers. Thirteen correlations involved HRV frequency domain parameters, and 28 involved HRV time domain characteristics. HRV indexes were linked to OTS markers such as physical performance and psychological aspects in soccer players. Standardization in research methodologies, addressing confounding factors, and exploring additional indexes are crucial in the future.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 10","pages":"e70357"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation into sleep, perceived experiences, and exercise performance in elite male cyclists during the Tour de France. 在环法自行车赛期间，对优秀男性自行车手的睡眠、感知体验和运动表现的调查。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70395

Josh Fitton, Bastien Lechat, Amy C Reynolds, Barbara Toson, Jack Manners, Phuc Nguyen, Kelly A Loffler, Thomas J Altree, Peter Catcheside, Danny J Eckert

{"title":"An investigation into sleep, perceived experiences, and exercise performance in elite male cyclists during the Tour de France.","authors":"Josh Fitton, Bastien Lechat, Amy C Reynolds, Barbara Toson, Jack Manners, Phuc Nguyen, Kelly A Loffler, Thomas J Altree, Peter Catcheside, Danny J Eckert","doi":"10.14814/phy2.70395","DOIUrl":"10.14814/phy2.70395","url":null,"abstract":"This study explores the dynamics of sleep, somatic/psychological experience, and exercise performance before, during, and after the Tour de France (TDF). Objective and subjective sleep, self-reported perceived experience, and objective exercise performance data were collected daily from eight elite male cyclists across a 6-week period including the 3-week TDF and 11-day pre- and post-race periods. Associations between, and temporal changes in, primary interest metrics were explored through Pearson correlation and linear mixed models. Participants were (mean ± SD) aged 30 ± 4 years with overall objective sleep duration of 8 h 11mins (±58 min) per night. Sleep quality (0-100) was lower during the race than pre-race (β [95% CI]; -8.0[-11.7, -4.3]). During the pre-race period, sleep onset (4 [2, 5] mins) and offset times delayed (5 [3, 7] mins) and self-reported stress increased (1.87 [1.14, 2.61]) daily. Increases in muscular soreness (0.6 [0.3, 0.8]) and fatigue (0.4 [0.2, 0.6]) during the race preceded daily declines during the post-race period (-3.1 [-4.0, -2.1]; -2.7 [-3.5, -1.8]). Relative performance output (Performance Index; 0-1000) negatively predicted sleep duration (r [95% CI]; -0.32 [-0.46, -0.17]) and sleep quality (-0.34 [-0.47, -0.19]) during the race. Temporal changes in, and associations between, sleep timing, perceived experience, and exercise function highlight the potential for sleep-improvement strategies that enhance performance in naturalistic endurance sporting contexts.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 10","pages":"e70395"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome affects mice metabolic homeostasis via differential regulation of gene expression in the brain and gut. 微生物组通过对大脑和肠道基因表达的差异调节影响小鼠代谢稳态。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70373

Wynne Milhouse, Anna Clapp Organski, Xun Sun, Derek Ai, Baohua Zhou, Tzu-Wen L Cross, Hongxia Ren

{"title":"Microbiome affects mice metabolic homeostasis via differential regulation of gene expression in the brain and gut.","authors":"Wynne Milhouse, Anna Clapp Organski, Xun Sun, Derek Ai, Baohua Zhou, Tzu-Wen L Cross, Hongxia Ren","doi":"10.14814/phy2.70373","DOIUrl":"10.14814/phy2.70373","url":null,"abstract":"The gut microbiome (GMB) regulates digestion, metabolism, immunity, and energy homeostasis. This study investigates how gut microbiota integrate the regulation in the neuroendocrine and enteroendocrine systems, with a focus on G protein-coupled receptors (GPCRs) in the brain-gut axis and sex differences. Germ-free (GF) mice exhibited increased hypothalamic expression of the anorexigenic neuropeptide and decreased expression of the negative regulator of leptin signaling. GF males had significantly lower serum leptin levels compared to conventional (CON) males, highlighting a potential link between the microbiome and leptin resistance. In the gut, GF mice demonstrated heightened expression of anorexigenic gut hormones, including peptide YY (Pyy) and cholecystokinin (Cck), in addition to increased levels of G protein-coupled receptors (GPCRs) involved in gut hormone secretion and nutrient metabolism, particularly in females. While carbohydrate metabolism genes were upregulated in CON mice, lipid metabolism genes were predominantly higher in GF mice. These findings suggest that the gut microbiota downregulates genes involved in appetite suppression, modulates GPCRs linked to gut hormone secretion, and contributes to leptin resistance, particularly in males. This research underscores the importance of the gut microbiome in host metabolism and reveals potential molecular targets for novel treatments of metabolic diseases.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 10","pages":"e70373"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging-associated changes in immunological parameters: Implications for COVID-19 immune response in the elderly. 与年龄相关的免疫参数变化：对老年人COVID-19免疫反应的影响

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70364

Maha Gasmi, Mahdi Hejazi, Antonella Muscella, Santo Marsigliante, Aastha Sharma

引用次数: 0

Analysis of the effect of 6-Hz binaural beats on electroencephalographic and autonomic parameters of healthy individuals: An exploratory study. 6赫兹双耳节拍对健康人脑电图和自主神经参数影响的探索性研究。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70271

Irene Scala, Jessica Marotta, Valerio Brunetti, Filippo Del Tedesco, Rikardo Xhemalaj, Pier Andrea Rizzo, Giovanni Frisullo, Eleonora Rollo, Maria Grazia Bocci, Edoardo Piervincenzi, Giacomo Della Marca, Riccardo Maviglia

{"title":"Analysis of the effect of 6-Hz binaural beats on electroencephalographic and autonomic parameters of healthy individuals: An exploratory study.","authors":"Irene Scala, Jessica Marotta, Valerio Brunetti, Filippo Del Tedesco, Rikardo Xhemalaj, Pier Andrea Rizzo, Giovanni Frisullo, Eleonora Rollo, Maria Grazia Bocci, Edoardo Piervincenzi, Giacomo Della Marca, Riccardo Maviglia","doi":"10.14814/phy2.70271","DOIUrl":"10.14814/phy2.70271","url":null,"abstract":"Binaural beats (BB) are a non-acoustic perception generated when two pure tones with a slight mismatch in frequency are presented separately to each ear. The aims of our study were to analyze the ability of 6-Hz BB in entraining cortical activity, altering cortical connectivity, and influencing Autonomic Nervous System (ANS) functioning to evaluate, in future studies, their application in improving compliance with Non-Invasive Ventilation (NIV) in critically ill patients. Twenty healthy volunteers underwent four 10-min experimental auditory conditions while their electroencephalographic and polygraphic activities were recorded: Resting-state, 6-Hz BB, 6-Hz monaural beats (MB), and random noise (RN). Frequency analysis and analysis of lagged-phase connectivity were computed through eLORETA. Heart rate variability, respiratory rate, and pulse transit time were analyzed as indicators of ANS activity. 6-Hpz BB entrained cortical activity at the beat frequency in the left cuneus and precuneus, in contrast with other experimental conditions. All auditory stimuli increased the interhemispheric lagged-phase connectivity between auditory cortices. Contrary to MB and RN, BB induced only minimal changes in ANS parameters. 6-Hz BB is effective in entraining cortical activity and induces only minimal changes in ANS parameters. These findings support the future use of BB as tools for increasing NIV compliance.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 10","pages":"e70271"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia. 心肌梗死激活9p21.3同源位点的表达，但其缺失不会改变心肌缺血时的病理生理。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70344

Sanna Kettunen, Anna Slita, Tuisku Suoranta, Iida Räty, Svetlana Laidinen, Elias Ylä-Herttuala, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala

{"title":"Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia.","authors":"Sanna Kettunen, Anna Slita, Tuisku Suoranta, Iida Räty, Svetlana Laidinen, Elias Ylä-Herttuala, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala","doi":"10.14814/phy2.70344","DOIUrl":"10.14814/phy2.70344","url":null,"abstract":"Genetic variation in the 9p21.3 chromosomal region has one of the strongest associations known for coronary artery disease (CAD) that often leads to myocardial infarction (MI). This risk locus encodes a long noncoding RNA, ANRIL, which has been suggested to regulate the neighboring cyclin-dependent kinase inhibitors 2A and B (Cdkn2A/B), the key regulators of cell proliferation. In this study, we aimed to clarify the role of the 9p21.3 risk locus in acute and chronic myocardial ischemia in mice. Mice carrying a deletion equivalent to the human CAD risk interval (Chr4Δ70kb/Δ70kb) and wild type mice were exposed to MI and followed until 5 days or 4 weeks. In the wild type mice, expression of a lncRNA, Ak148321, was increased after MI, and Cdkn2a was upregulated in chronic ischemia. Chr4Δ70kb/Δ70kb downregulated both Cdkn2a/b, but this did not affect the survival or cardiac pathology after MI. These results suggest that the 9p21.3 locus is activated in response to cardiac ischemia. However, deficiency in the risk locus does not play a role in the cardiac pathophysiology in mice, supporting the studies suggesting the risk locus being more involved in the development of CAD, rather than the subsequent MI.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 10","pages":"e70344"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut-on-a-chip platforms: Bridging in vitro and in vivo models for advanced gastrointestinal research. 芯片上的肠道平台：桥接体外和体内模型用于先进的胃肠道研究。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70356

Awurama Ofori-Kwafo, Indira Sigdel, Earshed Al Mamun, Jasenka Zubcevic, Yuan Tang

引用次数: 0

Cardiac baroreflex sensitivity during repeated handgrip exercise: Comparisons with sit-stand maneuvers and spontaneous rest. 反复握力练习时的心脏压力反射敏感性：与坐立动作和自发休息的比较。

IF 2.2

Physiological Reports Pub Date : 2025-05-01 DOI: 10.14814/phy2.70352

Wenxing Qin, Marina Fukuie, Daisuke Hoshi, Shoya Mori, Tsubasa Tomoto, Shigehiko Ogoh, Jun Sugawara, Takashi Tarumi

{"title":"Cardiac baroreflex sensitivity during repeated handgrip exercise: Comparisons with sit-stand maneuvers and spontaneous rest.","authors":"Wenxing Qin, Marina Fukuie, Daisuke Hoshi, Shoya Mori, Tsubasa Tomoto, Shigehiko Ogoh, Jun Sugawara, Takashi Tarumi","doi":"10.14814/phy2.70352","DOIUrl":"https://doi.org/10.14814/phy2.70352","url":null,"abstract":"The cardiac baroreflex regulates arterial pressure via autonomic heart rate control. While sit-stand maneuvers (SSM) have been used to assess baroreflex sensitivity (BRS), they may be impractical for physically immobile individuals. This study examined cardiac BRS during repeated handgrip exercise (RHE) compared to SSM and spontaneous rest. Twenty participants (10 females) performed 5-min RHE and SSM at 0.10 and 0.05 Hz in random order after spontaneous rest. Cardiac BRS was calculated using transfer function analysis (BRSTFA) and the sequence method (BRSSM) in low (LF: 0.05-0.15 Hz) and very low (VLF: 0.02-0.07 Hz) frequencies. Power spectral density (PSD) quantified systolic blood pressure (SBP) and R-R interval (RRI) oscillations. Compared to rest, 0.10 and 0.05 Hz RHE significantly increased SBP and RRI PSDs, with the highest values observed during SSM in both frequencies. RHE significantly increased LF and VLF BRSTFA coherence by 132% and 142%, while SSM increased them by 144% and 209%. Regardless of analytical methods, BRS remained unchanged during RHE compared to rest, but it significantly decreased during 0.10 Hz SSM, which correlated with increased heart rate. These findings suggest that RHE improves BRSTFA estimation via increased coherence, whereas reduced BRS during SSM suggests baroreflex resetting.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 9","pages":"e70352"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0