Physiological Reports最新文献

Influence of 8-week endurance training on resting energy expenditure and body composition in women. 8周耐力训练对女性静息能量消耗和身体成分的影响。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70591

Ida E Löfberg, Aino Kuljukka, Vera M Salmi, Johanna K Ihalainen, Heikki Kyröläinen, Anthony C Hackney, Ritva S Mikkonen

{"title":"Influence of 8-week endurance training on resting energy expenditure and body composition in women.","authors":"Ida E Löfberg, Aino Kuljukka, Vera M Salmi, Johanna K Ihalainen, Heikki Kyröläinen, Anthony C Hackney, Ritva S Mikkonen","doi":"10.14814/phy2.70591","DOIUrl":"10.14814/phy2.70591","url":null,"abstract":"Endurance training potentially induces changes in resting energy expenditure (REE), body composition, and metabolic hormones, but well-controlled studies accounting for hormonal status of women are sparse on this topic. This study investigated how 8-week moderate intensity endurance training (MIET) affects these outcomes in recreationally active women. Naturally menstruating women (NoOC, n = 17) and combined oral contraceptive users (COC, n = 8) were assessed in the luteal/follicular phases and active/inactive phases before and after MIET. REE and respiratory exchange ratio (RER; by indirect calorimetry), body composition, estradiol, progesterone, free triiodothyronine (fT3), acylated and unacylated ghrelin were measured at rest. Linear mixed models with time, group, and their interaction were used to analyze the results in two stratified phase comparisons. No interaction effects were observed, but a main effect of time for RER was observed in the pooled sample, indicating a 5.6% increase (p = 0.004) at follicular/inactive phase. The COC group also had higher fT3 concentrations at all time points (p < 0.05). Two participants from different groups showed consistent ≥10% REE changes. An 8-week MIET did not induce detectable changes in REE, body composition, or metabolic hormones on a group level, but high individual variation was observed.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70591"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV-1 viral protein effect on cerebral microvasculature: An in vitro blood-brain barrier model. HIV-1病毒蛋白对脑微血管的影响：体外血脑屏障模型。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70593

Sinelisiwe Matubatuba, Chontrelle Willemse, Khayelihle Brian Makhathini, Carine Smith, David Fisher, Shireen Mentor

{"title":"HIV-1 viral protein effect on cerebral microvasculature: An in vitro blood-brain barrier model.","authors":"Sinelisiwe Matubatuba, Chontrelle Willemse, Khayelihle Brian Makhathini, Carine Smith, David Fisher, Shireen Mentor","doi":"10.14814/phy2.70593","DOIUrl":"10.14814/phy2.70593","url":null,"abstract":"The central nervous system (CNS) serves as a sanctuary for the Human Immunodeficiency Virus (HIV), which is facilitated by HIV's ability to breach the blood-brain barrier (BBB). BBB dysfunction occurs in the earliest stages of an HIV-1 infection. The immune-privileged CNS reduces harmful inflammatory responses, detrimental to the neuronal environment. BBB disruption, however, contributes to comorbidities in HIV, like cerebrovascular disease and neurocognitive problems. A 2-dimensional in vitro BBB model was employed to assess the effect of HL2/3 cell paracrine factors on select physiological parameters: cell proliferation, viability, toxicity, suppression, and morphology. BBB integrity was assessed using transendothelial electrical resistance measurements. The study utilized immortalized mouse brain endothelial cell monocultures and co-cultures with the HL2/3 cell line, emulating an in vivo HIV-1 effect on the BBB. A concentration-dependent decline in cellular proliferation rates and viability was observed upon exposure to HL2/3 paracrine factors. Moreover, an elevation in cellular suppression, cell death, and cell toxicity was observed. Permeability studies confirmed decreased impermeability after exposure to HIV-1 viral proteins in select in vitro BBB model systems. The impact of HIV viral proteins on brain capillary endothelium is critical to elucidate pathogen-induced cerebrovascular disease progression and vascular cognitive impairment in patients.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70593"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of uninterrupted and interrupted sitting on vascular function in adults with long COVID. 不间断和间断坐位对长冠成人血管功能的影响。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70452

Nick Hudson, Scott Hannah, Margaret Husted, Simon Fryer, Helen Ryan-Stewart, Mark Rickenbach, Keeron Stone, James Faulkner

{"title":"The effect of uninterrupted and interrupted sitting on vascular function in adults with long COVID.","authors":"Nick Hudson, Scott Hannah, Margaret Husted, Simon Fryer, Helen Ryan-Stewart, Mark Rickenbach, Keeron Stone, James Faulkner","doi":"10.14814/phy2.70452","DOIUrl":"https://doi.org/10.14814/phy2.70452","url":null,"abstract":"Acute prolonged sitting increases blood pressure (BP) and arterial stiffness (AS). Both of these may be mitigated via light physical activity (LPA). Whether long COVID (LC), which partly manifests as vascular sequelae, predisposes a heightened sensitivity to sitting or diminished benefits from its interruption is unknown. The aims of this study were to identify whether individuals with LC: (i) exhibit a worse BP/AS response to uninterrupted sitting and (ii) a diminished mitigation of BP/AS response to sitting interrupted with LPA, compared to healthy controls. Thirty participants with LC and 15 controls completed 2 h of uninterrupted sitting and sitting interrupted with LPA. Central and peripheral systolic and diastolic BP and carotid-femoral pulse wave velocity (cfPWV) were determined pre and post sitting. Linear mixed-effects models demonstrated no three-way or two-way interactions for any variable. There was a significant main effect of time, with increases in central systolic (MD = 3.37 mmHg, SE = 0.93 mmHg, p < 0.001) and central diastolic (MD = 3.00 mmHg, SE = 0.58 mmHg, p < 0.001) BP. cfPWV was not altered in sitting in either group (MD = 0.13 m/s, SE = 0.09 m/s, p = 0.170). Uninterrupted sitting increases BP similarly, but AS is unchanged. Interrupting sitting with LPA did not mitigate sitting-induced increase in BP regardless of LC diagnosis.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70452"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac timing effects on response speed are modulated by blood pressure but not heart rate variability in healthy young adults. 在健康的年轻人中，心脏定时对反应速度的影响受血压调节，但不受心率变异性的调节。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70590

Xiao Yang, Catalina Roldan, Michael Gazzanigo, Yasmine Nabulsi, Fang Fang

{"title":"Cardiac timing effects on response speed are modulated by blood pressure but not heart rate variability in healthy young adults.","authors":"Xiao Yang, Catalina Roldan, Michael Gazzanigo, Yasmine Nabulsi, Fang Fang","doi":"10.14814/phy2.70590","DOIUrl":"10.14814/phy2.70590","url":null,"abstract":"Cardiac timing effects reflect the dynamic interplay between interoceptive and exteroceptive processes. Human information processing tends to be facilitated during cardiac diastole and inhibited during systole, reflecting autonomic regulation and the neuromodulation by baroreceptor afferents. Thus, blood pressure (BP) and vagally-mediated heart rate variability (vmHRV) are potential modulators of those effects. Additionally, cognitive control appears to play a critical role in the processes. However, whether cardiac timing effects are influenced by those factors remains unclear. The present study aimed to clarify these relationships. Fifty-one healthy young adults completed three experimental sessions to assess BP, short-term HRV, and cardiac timing effects. The Multi-Source Interference Task served as the cognitive task, with stimuli presented during either systole (R + 300 ms) or diastole (R + 550 ms). Repeated-measures ANCOVA and regression analyses were conducted to examine the effects of cardiac timing on response time (RT) and their associations with BP and vmHRV. Results indicated that higher BP predicted less RT slowing by systole in interference trials, while vmHRV was not linked to cardiac timing effects in interference or control trials. These findings suggest that individual differences in physiological functioning influence cardiac timing effects and contribute to better understandings of how interoceptive processes shape human cognition.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70590"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal and inflammatory responses to high-intensity functional training in male soldiers. 男性士兵对高强度功能性训练的激素和炎症反应。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70592

Joonas Helén, Heikki Kyröläinen, Tommi Ojanen, Kai Pihlainen, Risto Heikkinen, Jani P Vaara

{"title":"Hormonal and inflammatory responses to high-intensity functional training in male soldiers.","authors":"Joonas Helén, Heikki Kyröläinen, Tommi Ojanen, Kai Pihlainen, Risto Heikkinen, Jani P Vaara","doi":"10.14814/phy2.70592","DOIUrl":"10.14814/phy2.70592","url":null,"abstract":"This study investigated the effects of high-intensity functional training (HIFT) on hormonal and inflammatory biomarker responses during military service. One hundred and twenty-seven male conscripts were assessed over a 19-week training period. The experimental group (EXP: n = 64) followed a structured HIFT program, while the control group (CON: n = 63) adhered to conventional military physical training. Blood samples were collected at baseline (PRE), week 10 (MID), and post-intervention (POST) to measure serum testosterone, cortisol, testosterone/cortisol ratio, insulin-like growth factor 1 (IGF-1), sex hormone-binding globulin (SHBG), high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α). Body composition and physical performance were also measured. Serum testosterone increased in both groups between PRE and POST (EXP: +3.3 ± 3.8 nmol·L-1, p < 0.001; CON: +3.7 ± 3.4 nmol·L-1, p < 0.001), while cortisol remained unchanged. Testosterone/cortisol ratio increased in both groups (+0.010 ± 0.010, p < 0.001 for both). IGF-1 increased in CON (+4.4 ± 5.9 nmol·L-1, p < 0.001) and SHBG increased in EXP (+3.1 ± 9.0 nmol·L-1, p = 0.005). Inflammatory biomarkers (hs-CRP, IL-6) decreased in both groups. No adverse biomarker responses were observed, suggesting that HIFT was well tolerated during military service.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70592"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A characterization of dynamic resistance training-induced skeletal muscle adaptations in hypertensive rats. 动态阻力训练诱导高血压大鼠骨骼肌适应的表征。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70516

Amanda Aparecida de Araujo, Danielle da Silva Dias, Agnelo Neves Alves, Nathalia Bernardes, Rui Curi, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Raquel Agnelli Ferreira-Mesquita, Maria Claudia Irigoyen, Kátia De Angelis

{"title":"A characterization of dynamic resistance training-induced skeletal muscle adaptations in hypertensive rats.","authors":"Amanda Aparecida de Araujo, Danielle da Silva Dias, Agnelo Neves Alves, Nathalia Bernardes, Rui Curi, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Raquel Agnelli Ferreira-Mesquita, Maria Claudia Irigoyen, Kátia De Angelis","doi":"10.14814/phy2.70516","DOIUrl":"10.14814/phy2.70516","url":null,"abstract":"Resistance training (RT) is commonly recommended to increase muscle strength and to complement aerobic training for managing hypertension. However, the effects of RT on muscle adaptations in hypertensive individuals are not well understood. This study evaluated RT-induced muscular changes in spontaneously hypertensive rats (SHRs). Thirty-two adult SHRs were divided into four groups: sedentary females (SF), trained females (TF), sedentary males (SM), and trained males (TM). The trained groups underwent moderate-intensity dynamic RT 5 days per week for 8 weeks. Muscle assessments included measuring phosphofructokinase (PFK) activity, myosin heavy chain (MHC) expression, and fiber type. Blood pressure (BP) was measured directly. The results showed increased type IIB fibers in the trained females (TF) and more intermediate fibers in the trained males (TM). Trained rats displayed higher PFK activity and MHC IIB expression in the plantaris muscle. There were positive correlations between the maximal load test (MLT) and MHC IIB expression in all groups, MLT and intermediate fibers in males, and MLT and IIB fibers in females. No significant changes in BP were observed following the training period. These results suggest that RT promotes beneficial muscle adaptations in both sexes, with some sex-specific differences in fiber composition. Although BP was unchanged, the findings support RT as a strategy to improve functional capacity in this population.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70516"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague-Dawley rats. 雄性Sprague-Dawley大鼠对慢性约束应激的心脏反应涉及矿物皮质激素受体。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70549

D Sztechman, T Zera, K Czarzasta, E Szczepanska-Sadowska, A Cudnoch-Jedrzejewska

{"title":"Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague-Dawley rats.","authors":"D Sztechman, T Zera, K Czarzasta, E Szczepanska-Sadowska, A Cudnoch-Jedrzejewska","doi":"10.14814/phy2.70549","DOIUrl":"https://doi.org/10.14814/phy2.70549","url":null,"abstract":"In the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates the stress-induced changes. Young adult male Sprague-Dawley rats were divided into four groups: rats exposed to restraint stress, rats assigned to eplerenone treatment, rats exposed to restraint stress and eplerenone treatment, and a control group. After 4 weeks of the experiment, rats' blood pressure and heart rate were recorded, transthoracic echocardiography was performed, and blood samples and hearts were collected for further analysis. The study showed that chronic stress increases cardiac glucocorticoid mRNA expression but does not change the expression of MR mRNA. Chronic stress increases matrix metalloproteinases activity in the cardiac muscle. Mild left ventricular pro-hypertrophic changes were noted on echocardiogram. The changes were partially prevented by MR blockade with the use of eplerenone. These findings indicate that MRs participate in cardiac responses to chronic stress; however, this is not directly associated with significant changes in cardiac MRs expression.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70549"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial blood flow in patients with sepsis. 脓毒症患者的心肌血流量。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70605

Peter Andreas Christiansen, Farnoosh Nedaei, Casper Sejersen, Hannah G Caldwell, Lasse Gliemann, Anne Sofie Andreasen, Christian Søborg, Henrik Segelcke Thomsen, Jakob M Møller, Per Lav Madsen

{"title":"Myocardial blood flow in patients with sepsis.","authors":"Peter Andreas Christiansen, Farnoosh Nedaei, Casper Sejersen, Hannah G Caldwell, Lasse Gliemann, Anne Sofie Andreasen, Christian Søborg, Henrik Segelcke Thomsen, Jakob M Møller, Per Lav Madsen","doi":"10.14814/phy2.70605","DOIUrl":"10.14814/phy2.70605","url":null,"abstract":"The high mortality of systemic infection results from its associated cardiovascular depression. Cardiac depression typically normalizes if the patient recovers from the infection, but recent studies suggest that these patients have an increased long-term risk of developing cardiovascular disease after the septic episode. These findings have reignited interest in sepsis-associated cardiac function and myocardial blood flow, which remain poorly understood in humans. We studied cardiac function and myocardial microvascular perfusion using gadolinium-contrast magnetic resonance imaging in a cohort of patients during the initial recovery period of sepsis (n = 16) or septic shock (n = 5) and after full recovery 1-2 months later (n = 13). In addition, hepatic, splenic, and renal cortical perfusion were also assessed. With infection, cardiac output (+27%), the rate-pressure-product (+21%), and the left ventricle (LV) peak-ejection (+36%) and peak-filling (+35%) rates increased compared to full recovery (all p < 0.05). Onset of LV myocardial perfusion and the time to peak LV myocardial perfusion of gadolinium-contrast occurred earlier during initial than after recovery, with a numerically higher LV myocardium wash-in rate (23 ± 22 vs. 14 ± 14 s-1; p = 0.07). LV myocardial fibrosis was not seen in any patients. Renal cortical, splenic, and hepatic perfusion parameters including onset, time-to-peak, and wash-in rates of gadolinium contrast were comparable between initial and full recovery, except for a lower hepatic wash-in rate during initial recovery (13 ± 10 vs. 22 ± 16 s-1; p = 0.03). Our study supports that myocardial microvascular dysfunction is unlikely to contribute to cardiovascular disease after severe infection. Conversely, hepatic hypoperfusion during sepsis may explain the commonly observed hepatic dysfunction in sepsis.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70605"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory regulation and lung volume during aquatic and land-based exercise in healthy Young adults. 健康青年在水上和陆上运动期间的呼吸调节和肺容量。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70564

Daisuke Hoshi, Marina Fukuie, Tsubasa Tomoto, Wenxing Qin, Takashi Tarumi, Jun Sugawara, Koichi Watanabe

{"title":"Respiratory regulation and lung volume during aquatic and land-based exercise in healthy Young adults.","authors":"Daisuke Hoshi, Marina Fukuie, Tsubasa Tomoto, Wenxing Qin, Takashi Tarumi, Jun Sugawara, Koichi Watanabe","doi":"10.14814/phy2.70564","DOIUrl":"10.14814/phy2.70564","url":null,"abstract":"Elevated hydrostatic pressure during water immersion reduces lung volume and compliance at rest. These alterations may persist during exercise, influencing both the respiratory regulation and lung volume. This study compared respiratory regulation and lung volume between land-based (LC) and aquatic (AC) cycling matched for oxygen uptake (VO2). Ten healthy young adults underwent cycling at low and moderate intensities in both environments. Expiratory gas variables (VO2) and respiratory variables (minute ventilation and respiratory rate: VE and RR, respectively) were continuously measured using a breath-by-breath gas analyzer system. Ventilatory equivalent for VO2 (VE/VO2) was calculated. Using a spirometry system, expiratory and inspiratory reserve volumes (ERV and IRV, respectively), and tidal volume (VT) were measured at rest and at each exercise intensity using inspiratory maneuvers and normalized to forced vital capacity (FVC). Although VO2 was matched between conditions (p > 0.05), AC resulted in significantly higher VE, RR, and consequently VE/VO2 at moderate intensity. Additionally, ERV was lower and IRV was higher during AC compared with LC across all intensities, while FVCs remained unchanged in both conditions. These findings suggest a potential mechanism by which exercise in an aquatic environment may be more effective than land-based exercise for training the respiratory system.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70564"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults. 在成人自行车运动中，组胺受体阻断不影响重-重区域边界和重-重区域的任务失败时间。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70587

Kieran S S Abbotts, Jake H Hudgins, Isabella S Viveros, Christopher T Minson, Brad W Wilkins, John R Halliwill

{"title":"Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults.","authors":"Kieran S S Abbotts, Jake H Hudgins, Isabella S Viveros, Christopher T Minson, Brad W Wilkins, John R Halliwill","doi":"10.14814/phy2.70587","DOIUrl":"10.14814/phy2.70587","url":null,"abstract":"The influence of histamine in skeletal muscle during exercise is poorly characterized. This investigation tested the hypothesis that histamine-receptor blockade lowers the power associated with the heavy-severe domain boundary and reduces time to task failure in the severe domain. Following a graded exercise test and a familiarization trial, 17 participants (8 M/9 F, 29 ± 8 years, VO2peak 60.0 ± 7.5 mL/kg/min, mean ± SD) completed cycle ergometer exercise on two separate occasions, after either histamine-receptor blockade or placebo, in a double-blind randomized crossover protocol. Exercise intensities were designed to span the moderate, heavy, and severe domains. Skeletal muscle tissue oxygen saturation (%SmO2, via near-infrared spectroscopy) and expired gases were measured continuously throughout exercise. There were no differences between blockade and placebo in power associated with the heavy-severe domain boundary (216 [195, 236] vs. 213 [191, 234] W, mean [95% CI]; p = 0.41) or time to task failure (474 [377, 572] vs. 473 [380, 566] s; p = 0.95). %SmO2 slope decreased, and oxygen uptake increased with intensity (p < 0.01), but were not affected by blockade (all p > 0.05). These findings suggest that histamine is not crucial to supporting power at the heavy-severe domain boundary or short-duration exercise in the severe domain.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70587"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0