Physiological Reports最新文献

Cardiac energy metabolism is decreased in male volunteers with prediabetes and does not normalize during the day.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70242

Vera H W de Wit-Verheggen, Jakob Wefers, Carlijn M E Remie, Patrick Schrauwen, Vera B Schrauwen-Hinderling, Tineke van de Weijer

{"title":"Cardiac energy metabolism is decreased in male volunteers with prediabetes and does not normalize during the day.","authors":"Vera H W de Wit-Verheggen, Jakob Wefers, Carlijn M E Remie, Patrick Schrauwen, Vera B Schrauwen-Hinderling, Tineke van de Weijer","doi":"10.14814/phy2.70242","DOIUrl":"10.14814/phy2.70242","url":null,"abstract":"Type 2 diabetes mellitus is characterized by a low cardiac energy status (PCr/ATP ratio), but it is unknown whether this also applies to prediabetes. Since PCr/ATP is correlated with elevated free fatty acids (FFA), a potentially lower PCr/ATP might be secondary to elevated FFA. To investigate this, we determined PCr/ATP and FFA levels in volunteers with prediabetes at two time-points during the day. Eight male volunteers with prediabetes underwent a MRI/MRS scan to determine left ventricular ejection fraction (LVEF) and PCr/ATP ratio at 7 am and at 5 pm. For reference, these results were compared to eight non-insulin resistant overweight or obese volunteers. Myocardial energy status was lower in the volunteers with prediabetes (PCr/ATP 1.03 ± 0.08) compared to non-insulin resistant overweight or obese volunteers (PCr/ATP 1.22 ± 0.04, p < 0.05), but FFA were not significantly different between groups. LVEF was similar in the volunteers with prediabetes compared to healthy overweight and obese volunteers (p = 0.23). Volunteers with prediabetes have a lower myocardial energy status in the morning compared to healthy overweight and obese volunteers, while cardiac function remained normal. In addition, no differences between morning and evening measurements of cardiac energy status and function were found.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70242"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline arterial stiffness does not influence post-exercise reduction in pulse wave velocity.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70267

Natalia S Lima, Ronald E Jackson, Sara R Sherman, Brooks A Hibner, Bo Fernhall, Tracy Baynard, Craig Crandall, Shane A Phillips, Philip S Clifford

{"title":"Baseline arterial stiffness does not influence post-exercise reduction in pulse wave velocity.","authors":"Natalia S Lima, Ronald E Jackson, Sara R Sherman, Brooks A Hibner, Bo Fernhall, Tracy Baynard, Craig Crandall, Shane A Phillips, Philip S Clifford","doi":"10.14814/phy2.70267","DOIUrl":"10.14814/phy2.70267","url":null,"abstract":"We manipulated baseline peripheral arterial stiffness via changes in local arterial pressure with different limb positions to test the hypothesis that the magnitude of decrease in arterial stiffness post exercise/compression would be less when baseline stiffness is higher with the arm below the heart. Brachial-radial pulse wave velocity (PWV) was measured with tonometers in 19 healthy volunteers before and after 5 min of rhythmic handgrip exercise or passive forearm compressions with the arm positioned below or above the heart. Brachial-radial PWV was reduced 5 min after handgrip exercise below (10.4 ± 2.6 to 8.7 ± 2.2 m/s) and above (6.4 ± 1.3 to 5.3 ± 1.0 m/s) the heart, with no difference between positions (p > 0.05). PWV was also reduced 5 min after passive compressions with the arm below (10.8 ± 2.0 to 9.8 ± 2.1 m/s) and above (7.5 ± 1.4 to 5.7 ± 1.1 m/s), with no difference between positions (p > 0.05). Changes in local arterial pressure associated with arm position resulted in differences in baseline PWV but did not affect the magnitude of reduction in PWV with exercise or compressions. Reductions in peripheral arterial stiffness observed after rhythmic handgrip exercise and passive compressions were independent of baseline arterial stiffness.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70267"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing methods to measure the dispersion of breathing parameters during exercise testing: A simulation study based on real-life parameters from patients with dysfunctional breathing.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70233

Léon Genecand, Cyril Jaksic, Roberto Desponds, Gaëtan Simian, Ivan Guerreiro, Sara Thorens, Marco Altarelli, Isabelle Frésard, Chloé Cantero, Aurélien Bringard, Antoine Beurnier, Pierantonio Laveneziana, David Montani, Anne Bergeron, Frédéric Lador, Pierre-Olivier Bridevaux

{"title":"Comparing methods to measure the dispersion of breathing parameters during exercise testing: A simulation study based on real-life parameters from patients with dysfunctional breathing.","authors":"Léon Genecand, Cyril Jaksic, Roberto Desponds, Gaëtan Simian, Ivan Guerreiro, Sara Thorens, Marco Altarelli, Isabelle Frésard, Chloé Cantero, Aurélien Bringard, Antoine Beurnier, Pierantonio Laveneziana, David Montani, Anne Bergeron, Frédéric Lador, Pierre-Olivier Bridevaux","doi":"10.14814/phy2.70233","DOIUrl":"10.14814/phy2.70233","url":null,"abstract":"The dispersion of the tidal volume and of the breathing frequency have been used to diagnose dysfunctional breathing during cardio-pulmonary exercise testing. No validated methods to objectively describe this dispersion exist. We aimed to validate such a method. We used simulations based on real-life parameters. Moving standard deviation (MSD) and residuals from locally estimated scatterplot smoothing (LOESS) were evaluated. The precision and the bias of each tested method at rest and during exercise simulations, with and without sighs, were measured. For LOESS, a 2nd degree polynomial was used, and different spans were tested (LOESS1, LOESS0.75, and LOESS0.5). For MSD, different number of points used for the calculation were tested (MSD7, MSD11, MSD15, and MSD19). The LOESS method was globally more precise, had less bias, and was less influenced by the trend as compared to MSD in almost all simulations except for extremely low dispersion combined with extreme trends. LOESS0.75 had intermediate bias and precision between LOESS0.5 and LOESS1 in all simulations. LOESS0.75 is a method that combines high precision, low bias, and low influenceability of trends. It could be considered as the method of choice to evaluate the dispersion of breathing parameters during cardiopulmonary exercise testing.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70233"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A ketogenic-promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70208

Christopher D Crabtree, Yue Pan, Preethi Chandrasekaran, Yuwei Wang, Debbie Scandling, Teryn Bedell, Justen Stoner, Drew Decker, Madison Kackley, Bradley Robinson, Alex Buga, Yuchi Han, Jeff Volek, Orlando P Simonetti

{"title":"A ketogenic-promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation.","authors":"Christopher D Crabtree, Yue Pan, Preethi Chandrasekaran, Yuwei Wang, Debbie Scandling, Teryn Bedell, Justen Stoner, Drew Decker, Madison Kackley, Bradley Robinson, Alex Buga, Yuchi Han, Jeff Volek, Orlando P Simonetti","doi":"10.14814/phy2.70208","DOIUrl":"https://doi.org/10.14814/phy2.70208","url":null,"abstract":"Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1-4 mM). This study characterized cardiac function and blood flow responses to a ketogenic beverage compared to a volume/calorie matched placebo with repeated imaging over 120 min. This was a two-group, placebo-controlled, acute cardiac imaging study. Adults without cardiac abnormalities underwent baseline cardiac MRI including quantitative myocardial perfusion to measure myocardial blood flow (MBF). Subjects consumed 50 g of a ketogenic-promoting beverage [bis-hexanoyl R-1-3-butanediol (BH-BD)] (BH-BD; n = 11) or a calorically/volume-matched lipid-based placebo (PL; n = 10) with cardiac MRI every 15-30 min. Following 120 min, subjects underwent a final scan including MBF measurement. R-BHB and glucose were measured at every timepoint. 120 min following BH-BD consumption, R-BHB reached 2.1 mM. Cardiac output (CO) was elevated compared to PL (p < 0.05) and increased +31% 120 min after BH-BD ingestion (p < 0.001). CO elevation was due to increased stroke volume (+11%; p = 0.02) and heart rate (+22%; p < 0.001). MBF increased 29% from baseline (p < 0.001). PL did not induce differences in cardiac parameters. 50 g BH-BD ingestion achieves exogenous ketosis and is associated with elevated MBF and CO providing evidence supporting their use as a therapeutic clinical agent.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70208"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticomuscular and intermuscular coherence during evidence accumulation in sensorimotor decision-making.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70237

Yvonne F Visser, W Pieter Medendorp, Luc P J Selen

{"title":"Corticomuscular and intermuscular coherence during evidence accumulation in sensorimotor decision-making.","authors":"Yvonne F Visser, W Pieter Medendorp, Luc P J Selen","doi":"10.14814/phy2.70237","DOIUrl":"https://doi.org/10.14814/phy2.70237","url":null,"abstract":"Evidence accumulation processes during decision-making are thought to continuously feed into the motor system, preparing multiple competing motor plans, of which one is executed when the evidence is complete. Previously, the state of this accumulation process has been studied by reading out the preparatory state of the motor system with evoked responses, once per trial. In this study, we aim to continuously track the sensorimotor decision during the trial using corticomuscular (CMC) and intermuscular coherence (IMC). We recorded EEG and EMG of healthy young adults (n = 34) who viewed random dot motion stimuli, with varying strengths across trials, and indicated their perceived motion direction by reaching towards one of two targets, requiring either flexion or extension of the elbow. Coherence was computed in the beta band. After stimulus presentation, both CMC and IMC show an initial phasic pattern, which is followed by sustained coherence patterns at a level that depends on stimulus strength for CMC. Prior to reach onset, the CMC for different stimulus strengths had a tendency to settle at similar levels. This tendency tentatively marks a stimulus-independent decision bound. We conclude that CMC, and to a lesser extent IMC, track the evidence accumulation process on a single trial.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70237"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rest-to-work and work-to-rest transients of interstitial PO₂ in spinotrapezius muscle of young and old male rats.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70260

Aleksander S Golub, William H Nugent, Roland N Pittman, Bjorn K Song

{"title":"Rest-to-work and work-to-rest transients of interstitial PO2 in spinotrapezius muscle of young and old male rats.","authors":"Aleksander S Golub, William H Nugent, Roland N Pittman, Bjorn K Song","doi":"10.14814/phy2.70260","DOIUrl":"10.14814/phy2.70260","url":null,"abstract":"Muscle function declines with age. Since the primary energy source for contraction is aerobic, this study investigated age-related changes in muscle oxygenation dynamics to: characterize PO2 transients during rest-work transitions, identify age-specific differences in oxygen delivery/utilization balance, and examine the relationship between interstitial and arterial oxygen tension (PO2). Interstitial PO2 was measured with a high-resolution stroboscopic phosphorescence quenching technique to map intra-contractile dynamics during changes in muscle activity-rest-to-work (RtW) and work-to-rest (WtR) in rats aged three (young) and 23 (old) months. RtW (τw) and WtR (τr) PO2 transitions had lag periods and mono-exponential time constants. In young muscles, lag was 4 s, τw = 9.0 ± 3.7 s, and τr = 15.4 ± 3.9 s. For old, lag was also 4 s with increases to τw = 15.9 ± 3.5 s and τr = 41.4 ± 8.3 s. Resting PO2's were higher for young than for old (66.7 ± 13.7 vs. 60.2 ± 13.0 mmHg; p < 0.05). Work reduced PO2 with a greater effect on old (42.5 ± 14.0 vs. 28.3 ± 16.5 mmHg; p < 0.05). Intra-contractile measurements revealed a spike in PO2 (11 mmHg amplitude for >200 ms), which was absent in old. Further, sustained exercise in young showed a rising trend in PO2, while old remained at nadir. The missing PO2 spike in aged muscle contributes to reduced PO2 during work and may explain age-related loss of endurance.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70260"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural analysis of mitochondrial morphology and in the human rhabdosphincter: Insights into urinary incontinence.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70265

Shinro Hata, Mayuka Shinohara, Hiromitsu Mimata, Toshitaka Shin

{"title":"Ultrastructural analysis of mitochondrial morphology and in the human rhabdosphincter: Insights into urinary incontinence.","authors":"Shinro Hata, Mayuka Shinohara, Hiromitsu Mimata, Toshitaka Shin","doi":"10.14814/phy2.70265","DOIUrl":"10.14814/phy2.70265","url":null,"abstract":"Urinary incontinence increases with age, reducing the elderly quality of life. Understanding its mechanisms and developing treatments are urgent tasks. While healthy striated muscle maintains homeostasis through mitophagy, aging is thought to reduce autophagy activity. This study aimed to detect abnormal mitochondrial accumulation in the rhabdosphincter using transmission electron microscopy (TEM). We collected the rhabdosphincter samples from seven patients undergoing cystectomy and used the rectus abdominis as controls. Both tissues were examined with Hematoxylin and eosin (HE) staining and TEM. ImageJ software was used to measure the mitochondrial area, perimeter, and luminance. HE staining revealed that the rhabdosphincter had fewer muscle fibers and more stromal tissue than the rectus abdominis. TEM images showed more gaps in muscle bundles and signs of mitochondrial damage, vacuolation, and swelling in the rhabdosphincter. Quantitative analysis revealed a larger average mitochondrial area (0.21 μm2 vs. 0.063 μm2, p < 0.01), longer perimeter (1.83 μm vs. 0.94 μm, p < 0.01) and higher luminance (156.6 vs. 90.2, p < 0.01) than those of the rectus abdominis. The rhabdosphincter of elderly individuals showed significant mitochondrial morphological abnormalities, with increased swelling and vacuolation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70265"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ML-UrineQuant: A machine learning program for identifying and quantifying mouse urine on absorbent paper.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70243

Warren G Hill, Bryce MacIver, Gary A Churchill, Mariana G DeOliveira, Mark L Zeidel, Marcelo Cicconet

引用次数: 0

Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70142

Simon Lui, Arash Tadjalli, Jimmy Fraigne, John Peever

{"title":"Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.","authors":"Simon Lui, Arash Tadjalli, Jimmy Fraigne, John Peever","doi":"10.14814/phy2.70142","DOIUrl":"10.14814/phy2.70142","url":null,"abstract":"The respiratory control system can exhibit neuronal plasticity following exposures to repetitive respiratory challenges. For example, repeated obstructive apneas can trigger a form of respiratory plasticity that results in the enhancement of inspiratory hypoglossal (XII) motoneuron activity. This increase in respiratory motor output is known as hypoglossal long-term facilitation (hLTF). In adult male Sprague-Dawley rats, we demonstrate that hLTF can also be triggered in the absence of repeated apneas by intermittent optogenetic stimulation of locus coeruleus (LC) neurons, or through pharmacological activation of adenosine-A2a-receptors at the level of brainstem XII motor pool. Both our pharmacological and optogenetic approaches that trigger hLTF require noradrenergic signaling through activation of α1-noradrenergic receptors on hypoglossal motoneurons. We also use optical LC inhibition to reaffirm the importance of the LC in mediating apnea-induced hLTF. These results demonstrate that hLTF can be triggered by multiple hypoxia-independent stimuli, and for the first time, identify the LC as a key brainstem source for noradrenaline necessary for the expression of hLTF.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70142"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis-a pilot study in adult patients.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70179

Fansan Zhu, Laura Rosales Merlo, Lela Tisdale, Maricar Villarama, Jun Yi, Zahin Haq, Xiaoling Wang, Nadja Grobe, Karsten Fischer, Kulwinder Plahey, Richard A Lasher, Paul Chamney, Brigitte Schiller, Peter Kotanko

{"title":"Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis-a pilot study in adult patients.","authors":"Fansan Zhu, Laura Rosales Merlo, Lela Tisdale, Maricar Villarama, Jun Yi, Zahin Haq, Xiaoling Wang, Nadja Grobe, Karsten Fischer, Kulwinder Plahey, Richard A Lasher, Paul Chamney, Brigitte Schiller, Peter Kotanko","doi":"10.14814/phy2.70179","DOIUrl":"10.14814/phy2.70179","url":null,"abstract":"Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2-h dwell using 2 L of dialysate containing 2.5% dextrose. IPP was measured using a pressure sensor integrated into an automated PD cycler. IPV was monitored concurrently by segmental bioimpedance (Hydra 4200). The density (ρ) of the PD dialysate was measured using a meter, and the creatinine and glucose concentrations in both dialysate (D) and serum (P) were measured pre- and post-PD dwell. A physical model (IPP = ρ × g × h), was used to describe the relationship between IPP and IPV, where h is the apparent dialysate height and g is the gravitational acceleration. The change in IPP (ΔIPP, -21.2 ± 18%) was mainly determined by the change of h (Δh, -20.9 ± 18.5%), while the change ρ (Δρ, -0.34 ± 0.06%), was minor. The study demonstrated an association between ΔIPP and the ratio of D/P creatinine and D/D0 glucose, suggesting that ΔIPP may reflect membrane transport characteristics. Due to its noninvasive and seamless nature, the clinical utility of PD cycler-based measurement of IPP warrants further exploration.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70179"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0