Physiological Reports最新文献

Water intake regulates mucosal immunity in rat jejunal villi via IL-1β, IL-6, and IL-10. 饮水量通过IL-1β、IL-6和IL-10调节大鼠空肠绒毛黏膜免疫。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70891

Norika Kuneshita, Yuki Sakai, Moyuru Hayashi, Tomomi Watanabe-Asaka, Daisuke Maejima, Yoshiko Kawai, Toshio Ohhashi

{"title":"Water intake regulates mucosal immunity in rat jejunal villi via IL-1β, IL-6, and IL-10.","authors":"Norika Kuneshita, Yuki Sakai, Moyuru Hayashi, Tomomi Watanabe-Asaka, Daisuke Maejima, Yoshiko Kawai, Toshio Ohhashi","doi":"10.14814/phy2.70891","DOIUrl":"10.14814/phy2.70891","url":null,"abstract":"We had demonstrated that the intragastric administration of distilled water increased male rat jejunal lymph flow and interleukin-22 levels in the lymph, resulting in the promotion of innate immunity. However, there is no information concerning whether the water intake regulates mucosal immunity in the jejunum of male rats. Based on the evidence, we investigated the effects of distilled water intake on gut immunity in the rat jejunum. Water intake significantly stimulated the release of IL-1β and IL-6 in mesenteric lymph. However, the concentration of IL-10 was not changed by water intake. Pretreatment with clodronate significantly decreased the lymph flow at 120-180 min after the intake. Clodronate significantly reduced water intake-mediated release of IL-1β and decreased, but not significantly, the release of IL-6. MyD88 inhibitor significantly decreased water intake-mediated release of IL-1β and IL-6. However, clodronate and MyD88 inhibitor did not significantly change IL-10 in the lymph. The expression levels of the macrophage markers CD68, F4/80, and CD169 in the jejunal villi significantly decreased due to pretreatment with clodronate. These findings suggest that water intake acts as a trigger for starting mucosal immunity in the jejunum via macrophage and MyD88-mediated activation of the release of IL-1β and IL-6.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70891"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-of-day, satellite cells, and velocity collectively influence ex vivo isovelocity force production in mouse extensor digitorum longus muscle. 一天中的时间、卫星细胞和速度共同影响小鼠指长伸肌的离体等速力产生。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70902

Ryan E Kahn, Sudarshan Dayanidhi, Richard L Lieber

{"title":"Time-of-day, satellite cells, and velocity collectively influence ex vivo isovelocity force production in mouse extensor digitorum longus muscle.","authors":"Ryan E Kahn, Sudarshan Dayanidhi, Richard L Lieber","doi":"10.14814/phy2.70902","DOIUrl":"10.14814/phy2.70902","url":null,"abstract":"Skeletal muscles are exquisitely designed to produce force that facilitate movement. Circadian \"molecular clocks\" residing in muscle play a role in regulating force production with muscle stem cell (satellite cells, SC) molecular clocks modulating isometric and eccentric force according to time-of-day. However, many tasks of daily living and exercise (i.e., walking/running) involve force and power produced during muscle shortening. Thus, the purpose of this study was to determine whether isovelocity forces and power are also modulated by SCs according to time-of-day. Using previously published samples (a mouse model capable of SC ablation), we evaluated isovelocity forces across a range of velocities (1-11 Lf/s) at two different times of day ZT1, ZT9 in the presence and absence of SCs. The main finding of this investigation was that isovelocity force production is regulated by a third-order interaction effect between time-of-day × SCs × velocity (p < 0.001). Additionally, a significant effect of time-of-day was observed for isovelocity force and power when comparing ZT1 vs. ZT9 SC+ mice whereas this effect was absent in SC- animals. These results suggest SCs harbor a time-of-day and velocity dependent effect on isovelocity force production and power. Further work is required to elucidate the underlying mechanisms of this phenomenon.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70902"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnitude and variability of blood pressure and renal vascular conductance responses to postural changes, exercise, and cold in black adults: A pilot study. 黑人成人对体位改变、运动和寒冷的血压和肾血管传导反应的幅度和变异性：一项初步研究

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70888

Mohamed H Ibrahim, Alison J McLure, Mary J Jackson, Brittany Harrison, Sarah Brockley, Elizabeth C Jones, A Parker Ruhl, Hans C Ackerman

{"title":"Magnitude and variability of blood pressure and renal vascular conductance responses to postural changes, exercise, and cold in black adults: A pilot study.","authors":"Mohamed H Ibrahim, Alison J McLure, Mary J Jackson, Brittany Harrison, Sarah Brockley, Elizabeth C Jones, A Parker Ruhl, Hans C Ackerman","doi":"10.14814/phy2.70888","DOIUrl":"10.14814/phy2.70888","url":null,"abstract":"We developed a noninvasive approach to measure vascular responses to sympathetic stimuli. We hypothesized that standing, handgrip exercise, or cold exposure would raise blood pressure (BP) and lower renal vascular conductance (RVC). BP was recorded continuously and renal arterial velocity was measured using renal Doppler ultrasound. Repeated measures one-way ANOVA with Dunnett's post hoc test was used to compare BP during stimulation against baseline. Intraclass correlation analysis was used to compare first and second visits. Seven women and four men aged 29.9 ± 4.7 years participated. On first visits, standing from supine raised systolic BP by 11.9 ± 2.6 mmHg (p = 0.0018) and diastolic BP by 15.0 ± 1.9 mmHg (p < 0.0001). Handgrip exercise raised systolic BP by 15.9 ± 4.1 mmHg (p = 0.0146) and decreased systolic RVC by 0.68 ± 0.26 cm/s/mmHg (p = 0.0049). Cold increased systolic BP by 27.8 ± 3.4 mmHg (p < 0.0001) and decreased systolic RVC by 0.32 ± 0.07 cm/s/mmHg (p = 0.0049). BP and RVC responses were similar from visit one to visit two; however, most outcome measurements were not correlated within individuals. These findings expand our understanding of vasoregulation in Black adults and guide studies to characterize vascular function in the future.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70888"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of cooling garments on performance during and after vigorous, heart-rate-clamped exercise in young males under hot and humid conditions. 在炎热潮湿的条件下，年轻男性在剧烈、心率受限的运动期间和之后，冷却服装对运动表现的影响。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70898

Kazutaka Ota, Hiroaki Tamaru, Kazushige Sasaki

{"title":"Impact of cooling garments on performance during and after vigorous, heart-rate-clamped exercise in young males under hot and humid conditions.","authors":"Kazutaka Ota, Hiroaki Tamaru, Kazushige Sasaki","doi":"10.14814/phy2.70898","DOIUrl":"10.14814/phy2.70898","url":null,"abstract":"This study aimed to clarify the effects of the following cooling garments on performance during and after vigorous, heart-rate-clamped exercise under hot and humid conditions: base layers made of cross-shaped fibers (C), sugar alcohol-printed base layers (S), and a combination of S with a fan-attached jacket (S+F). Fifteen healthy male participants wore the cooling garments and rested for 20 min in a room set to ~30°C and ~60% relative humidity. The participants then completed a 20-min cycle ergometer exercise with heart rate clamped at 65% of heart rate reserve and rated their perceived exertion (RPE). Before and after exercise, we assessed thermal, comfort, and wetness sensations and measured body temperature, vertical jump height, ground reaction force during rising from the chair, visual reaction time, and the Stroop interference. Cooler sensations were consistently reported in the order of S+F, S, and C. Despite the lowest RPE, pedaling load was highest in S+F. Sweat loss was comparable among the conditions, while garment sweat absorption and post-exercise skin temperature were lowest in S+F. These results suggest that S+F improves endurance performance under hot and humid conditions through efficient evaporative heat loss mainly facilitated by increased airflow from the fans.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70898"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single intake of matcha increases brown adipose tissue activity in young women with low thermogenesis. 在低产热的年轻女性中，单次摄入抹茶会增加棕色脂肪组织的活性。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70896

Hirokazu Taniguchi, Chisaki Hachikawa, Sana Iwase, Shinsuke Nirengi, Tomomi Nagahata

{"title":"Single intake of matcha increases brown adipose tissue activity in young women with low thermogenesis.","authors":"Hirokazu Taniguchi, Chisaki Hachikawa, Sana Iwase, Shinsuke Nirengi, Tomomi Nagahata","doi":"10.14814/phy2.70896","DOIUrl":"https://doi.org/10.14814/phy2.70896","url":null,"abstract":"Matcha contains several bioactive compounds that contribute to the facilitation of thermogenesis. However, the effects of a single intake of matcha on brown adipose tissue (BAT) activity remain to be elucidated. This study aimed to evaluate the association between matcha intake and BAT activity. Healthy young women (n = 30) were enrolled in a randomized single-blind crossover trial. Participants consumed 3 g of matcha powder or a placebo and then received the alternate condition in a subsequent trial. BAT activity was analyzed using thermography with cold exposure. A stratified analysis was performed based on tertiles of maximal changes in BAT activity. BAT activity was increased for all participants following cold exposure; however, no significant difference in the increased levels was found between the matcha and placebo trials. Stratified analysis showed that BAT activity was significantly different in the placebo trial across the low, middle, and high tertile groups; however, this was not found in the matcha trial. Differences in maximal BAT activity between the matcha and placebo trials were significantly higher in the low activity group than in the other groups. These results suggest that matcha powder has beneficial effects on BAT thermogenesis in young women with lower BAT activity.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70896"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast dynamic voluntary contractions enhance corticospinal facilitation of the human diaphragm: A transcranial magnetic stimulation study. 快速动态自愿收缩增强人横膈膜的皮质脊髓易化：经颅磁刺激研究。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70905

Alexandre Demoule, Eric Verin, Capucine Morélot-Panzini, Christian Straus, Thomas Similowski

{"title":"Fast dynamic voluntary contractions enhance corticospinal facilitation of the human diaphragm: A transcranial magnetic stimulation study.","authors":"Alexandre Demoule, Eric Verin, Capucine Morélot-Panzini, Christian Straus, Thomas Similowski","doi":"10.14814/phy2.70905","DOIUrl":"10.14814/phy2.70905","url":null,"abstract":"In limb muscles, corticospinal excitability is modulated by motor context, with greater facilitation during movement initiation and dynamic contractions than during sustained isometric activation. Whether this applies to the human diaphragm remains uncertain, given the hybrid automatic-voluntary control and continuous activity of respiratory motoneurones. To determine whether corticospinal excitability of the human diaphragm is influenced by the dynamics of voluntary inspiratory contraction at a given level of inspiratory mouth pressure, nine healthy participants (3 women, 6 men; age 23-39 years) performed inspiratory efforts against an occluded mouthpiece. Diaphragm motor evoked potentials (Di-MEPs) elicited by transcranial magnetic stimulation were recorded from validated chest surface sites at end-expiration with the airway occluded, at rest, during sustained static inspiratory efforts at graded fractions of maximal inspiratory mouth pressure (Pi,max), and during dynamic inspiratory efforts matched for pressure (20% Pi,max) but differing in rate of pressure development (slow vs. fast). Static efforts increased Di-MEP amplitude and shortened latency in a pressure-dependent manner. Slow dynamic efforts produced similar facilitation to static efforts. Fast dynamic efforts elicited greater facilitation, with increased amplitude and shortened latency. Corticospinal excitability of the diaphragm is modulated by contraction dynamics, with rapid efforts inducing additional facilitation beyond force alone.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70905"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral blood velocity responses during and after sprint interval exercise in healthy young adults. 健康青年在冲刺间歇运动期间和之后的脑血流速度反应。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70901

E Scott, E Langson-Justice, O Smail, A B Lester, R Oliveira, C J A Pugh, M E Weston, B O Bond

{"title":"Cerebral blood velocity responses during and after sprint interval exercise in healthy young adults.","authors":"E Scott, E Langson-Justice, O Smail, A B Lester, R Oliveira, C J A Pugh, M E Weston, B O Bond","doi":"10.14814/phy2.70901","DOIUrl":"https://doi.org/10.14814/phy2.70901","url":null,"abstract":"This study investigated the middle (MCAv) and posterior (PCAv) cerebral artery blood velocity and end-tidal carbon dioxide (PETCO2) responses during sprint interval exercise (SIE). We also examined the relationships between MCAv, PCAv and blood pressure during the 60 min post SIE. Fourteen healthy adults completed four 30 s maximal cycle sprints, each separated by 4 min of unloaded cycling. MCAv and PCAv demonstrated a rapid increase followed by a return towards the initial baseline values during each sprint. The increase during the first sprint (MCAv: +31.9% ± 19.9%, PCAv: +32.5% ± 30.6%) was always greater than subsequent sprints (p ≤ 0.039). Each sprint was followed by a transient increase in MCAv and PCAv, which mirrored PETCO2. SIE was followed by 60 min of hypocapnia, and blood pressure was significantly lowered 10-20 and 40-55 min post SIE. However, resting MCAv was not altered, and PCAv was only lower 5 min post SIE. Resting MCAv phase and gain, and PCAv phase were largely unaltered apart from the first 5 min post SIE. The ability to buffer changes in blood pressure during repeated squat-stand maneuvers remained intact 60 min post SIE, although a greater fall in MCAv and PCAv was noted during a single sit-to-stand transition at this time.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70901"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ethanol on non-invasively recorded cerebellar, cerebral, and postural responses to axial perturbation: A case study. 乙醇对无创记录的小脑、大脑和体位对轴向扰动的反应的影响：一个案例研究。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70897

Neil P M Todd, Sendhil Govender, James G Colebatch

{"title":"Effects of ethanol on non-invasively recorded cerebellar, cerebral, and postural responses to axial perturbation: A case study.","authors":"Neil P M Todd, Sendhil Govender, James G Colebatch","doi":"10.14814/phy2.70897","DOIUrl":"10.14814/phy2.70897","url":null,"abstract":"We report for the first time non-invasively recorded ethanol (EtOH) induced changes in the spontaneous and evoked activity of the human cerebellum. We recorded electroencephalography (EEG), electro-cerebellography (ECeG), lower limb electro-myography (EMG), and posturography in a 64 year old adult male before and after oral ingestion of EtOH while standing at rest and in response to axial perturbation of the trunk. The a xial perturbation is known to give rise to a well-defined postural reflex of likely brain-stem origin in lower-limb muscles accompanied by correlated short and long latency cerebral and cerebellar responses. The associated cerebellar response is of likely climbing fiber (CF) origin, characterized by post-CF inhibition of the spontaneous Purkinje cell (PC) activity, non-invasively manifest as pausing in the high-frequency ECeG. In our case, EtOH reversibly attenuated the postural reflex and associated cerebral responses, whilst also causing an increase in the spontaneous high-frequency ECeG and severely disrupting the post-CF pausing of the ECeG in response to axial perturbation. The initial component of the CF response was unaffected, however, likely reflecting the afferent volley to the perturbation. These effects demonstrate that non-invasive recordings of cerebellar electrophysiology are possible and can provide important pathophysiological insights.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70897"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipocyte-specific FFA2 deletion leads to increased adipose inflammation and is associated with altered intestinal lipid handling in mice. 脂肪细胞特异性FFA2缺失导致脂肪炎症增加，并与小鼠肠道脂质处理改变有关。

IF 2.2

Physiological Reports Pub Date : 2026-05-01 DOI: 10.14814/phy2.70875

Chioma Nnyamah, James Boyett, Barton Wicksteed, Nupur Pandya, Kai Xu, Irene Corona-Avila, Nadia Sweis, Marissa St George, Laura J Den Hartigh, Abeer M Mahmoud, Yuwei Jiang, Jose Cordoba-Chacon, Medha Priyadarshini, Brian T Layden

{"title":"Adipocyte-specific FFA2 deletion leads to increased adipose inflammation and is associated with altered intestinal lipid handling in mice.","authors":"Chioma Nnyamah, James Boyett, Barton Wicksteed, Nupur Pandya, Kai Xu, Irene Corona-Avila, Nadia Sweis, Marissa St George, Laura J Den Hartigh, Abeer M Mahmoud, Yuwei Jiang, Jose Cordoba-Chacon, Medha Priyadarshini, Brian T Layden","doi":"10.14814/phy2.70875","DOIUrl":"https://doi.org/10.14814/phy2.70875","url":null,"abstract":"Obesity and related metabolic disorders are often characterized by chronic adipose tissue inflammation, driving systemic insulin resistance and general metabolic dysfunction. Free Fatty Acid Receptor 2 (FFA2) has emerged as a potential modulator of adipocyte function, inflammation, and metabolism. To investigate the role of FFA2 expressed in the adipose tissue, we generated adipose-specific FFA2 knockout mice (Adipoq-F2-KO) and assessed metabolic outcomes under standard laboratory chow and high-fat, high-sugar Western diet conditions, with and without dietary fiber supplementation. We found that adipose-specific FFA2 deletion had minimal metabolic consequences under standard dietary conditions but significantly reduced body weight and adiposity when mice were fed a fiber (fructooligosaccharide)-supplemented Western diet. Subsequent fecal analyses and transcriptomic profiling indicated impaired intestinal lipid absorption as the primary driver of reduced adiposity, suggesting disrupted adipose-intestinal communication. Unexpectedly, the lighter Adipoq-F2-KO mice also exhibited heightened adipose inflammation, characterized by increased macrophage infiltration and pro-inflammatory cytokine expression. Furthermore, in vitro loss-of-function experiments in adipocytes revealed that FFA2 knockdown impaired adipocyte maturation, lipid storage, and anti-inflammatory signaling. Additional studies using intestinal epithelial cells exposed to adipocyte-conditioned media implicated adipose-derived signals in driving intestinal dysfunction. Collectively, our findings highlight adipose-specific FFA2 as critical in regulating adipose tissue inflammation, lipid metabolism, and inter-organ communication.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 9","pages":"e70875"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific relation of replacing sedentary time with physical activity on stage 2 hypertension incidence in middle-aged adults. 用体力活动取代久坐时间与中年人2期高血压发病率的性别特异性关系。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70830

Sophie E Rayner, Jolaine Katryne Bossé, Corinne Brideau, Jolaine Comeau, Jessie Drouin, Jalila Jbilou, Myles W O'Brien

{"title":"Sex-specific relation of replacing sedentary time with physical activity on stage 2 hypertension incidence in middle-aged adults.","authors":"Sophie E Rayner, Jolaine Katryne Bossé, Corinne Brideau, Jolaine Comeau, Jessie Drouin, Jalila Jbilou, Myles W O'Brien","doi":"10.14814/phy2.70830","DOIUrl":"10.14814/phy2.70830","url":null,"abstract":"Hypertension is increasingly prevalent among middle-aged adults, but the impacts of physical activity and postures are not fully understood in middle-aged males and females, limiting targeted prevention. This study investigated associations between habitual physical activity and postures with hypertension, and whether they differ between sexes at the same age. 4416 participants (age: 46 years) in the 10th sweep of the 1970 British Cohort Study were used. Participants wore an activPAL to measure physical behaviors. Stage 2 hypertension was defined as >140/90 mmHg or antihypertensive medication use. Isotemporal substitution models assessed the theoretical effect of reallocating 30 min of one behavior with another. Males had higher mean body mass index (BMI: 28.5 ± 4.6 kg/m2 vs. 27.9 ± 6.0), systolic (129.1 ± 13.3 mmHg vs. 119.6 ± 14.7 mmHg) and diastolic blood pressure (79.0 ± 10.4 vs. 74.8 ± 10.7 mmHg) compared to females (all, p < 0.001). In pooled analyses, substituting sedentary time with light physical activity (LPA) (OR = 0.93 [0.86, 0.998]) or moderate-to-vigorous physical activity (MVPA) (OR = 0.90 [0.83, 0.97]) was associated with lower odds of hypertension. In males, replacing sedentary time or standing with any activity reduced hypertension risk (ORs 0.86-0.88), whereas in females, only replacing sedentary time with standing was associated with lower risk (OR = 1.04 [1.01, 1.07]). MVPA demonstrated stronger associations than LPA. Replacing sedentary or standing behaviors with movement, particularly MVPA, may reduce hypertension risk in middle-aged adults, with more pronounced benefits observed in males. These findings support the development of sex-specific interventions targeting physical activity behavior patterns to mitigate hypertension risk during midlife.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70830"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0