Physiological Reports最新文献

Associations between circulating amino acids and metabolic dysfunction-associated steatotic liver disease in individuals living with severe obesity.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70171

Ina Maltais-Payette, Jérôme Bourgault, Marie-Frédérique Gauthier, Laurent Biertho, Simon Marceau, François Julien, Patricia L Mitchell, Christian Couture, Francis Brière, Jacques Corbeil, Benoit J Arsenault, André Tchernof

{"title":"Associations between circulating amino acids and metabolic dysfunction-associated steatotic liver disease in individuals living with severe obesity.","authors":"Ina Maltais-Payette, Jérôme Bourgault, Marie-Frédérique Gauthier, Laurent Biertho, Simon Marceau, François Julien, Patricia L Mitchell, Christian Couture, Francis Brière, Jacques Corbeil, Benoit J Arsenault, André Tchernof","doi":"10.14814/phy2.70171","DOIUrl":"10.14814/phy2.70171","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) describes liver diseases caused by the accumulation of triglycerides in hepatocytes (steatosis) as well as the resulting inflammation and fibrosis. Previous studies have demonstrated that accumulation of fat in visceral adipose tissue compartments and the liver is associated with alterations in the circulating levels of some amino acids, notably glutamate. This study aimed to investigate the associations between circulating amino acids, particularly glutamate, and MASLD. In addition, we hypothesized that liver steatosis, concomitant with visceral adiposity, could contribute to the association between circulating glutamate and visceral obesity. We studied a sample of 150 patients living with severe obesity who were non-diabetic and selected to represent a wide range of MASLD severity. Liver histological features were determined by a pathologist from a biopsy sample obtained at the time of bariatric surgery. Bulk RNA sequencing measured the hepatic mRNA expression level of selected genes related to the urea cycle and glutamate metabolism. Fasting plasma amino acid levels were measured by liquid chromatography coupled with tandem mass spectrometry. Patients with more advanced steatosis had larger visceral adipocytes, higher levels of circulating tyrosine, glutamate, and alanine as well as lower levels of serine. MASLD severity was significantly associated with the hepatic mRNA expression of glutamate metabolism genes such as GLS1, GLUL (positively), and NAGS (inversely). In individuals living with obesity, MASLD severity is associated with visceral adipocyte hypertrophy, higher circulating glutamate as well as potential alterations of hepatic amino acid and nitrogen metabolism.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70171"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70135

Kunihiko Takahara, Noriyuki Ouchi, Tomonobu Takikawa, Yuta Ozaki, Lixin Fang, Hiroshi Kawanishi, Minako Tatsumi, Yoshimitsu Yura, Katsuhiro Kato, Mikito Takefuji, Toyoaki Murohara, Koji Ohashi

{"title":"Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice.","authors":"Kunihiko Takahara, Noriyuki Ouchi, Tomonobu Takikawa, Yuta Ozaki, Lixin Fang, Hiroshi Kawanishi, Minako Tatsumi, Yoshimitsu Yura, Katsuhiro Kato, Mikito Takefuji, Toyoaki Murohara, Koji Ohashi","doi":"10.14814/phy2.70135","DOIUrl":"10.14814/phy2.70135","url":null,"abstract":"Chronic kidney disease is a life-threatening disease worldwide. PPARα is a crucial transcriptional regulator of lipid metabolism and inflammation. Here, we examine whether a novel selective PPARα modulator, pemafibrate modulates renal injury in a model of unilateral ureteral obstruction (UUO). Administration of pemafibrate to wild-type (WT) mice led to reduction of renal dysfunction and fibrosis after UUO with accompanying increases in plasma levels of fibroblast growth factor (FGF) 21 and ketone body β-hydroxybutyrate (BHB). Treatment of WT mice with FGF21 or BHB precursor resulted in attenuation of renal fibrotic and inflammatory responses after UUO. Treatment of proximal tubular cells with FGF21 or BHB reduced expression of epithelial-mesenchymal transition markers. These findings suggest that pemafibrate could ameliorate renal damage, at least in part, by its abilities to increase the production of FGF21 and BHB.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70135"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of home-based hot bathing on exercise-induced adaptations associated with short-term resistance exercise training in young men.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70188

Ryosuke Takeda, Tsubasa Amaike, Taichi Nishikawa, Kohei Watanabe

{"title":"Effect of home-based hot bathing on exercise-induced adaptations associated with short-term resistance exercise training in young men.","authors":"Ryosuke Takeda, Tsubasa Amaike, Taichi Nishikawa, Kohei Watanabe","doi":"10.14814/phy2.70188","DOIUrl":"10.14814/phy2.70188","url":null,"abstract":"This study investigated whether home-based bathing intervention (HBBI) improve muscle strength gain and protect cardiovascular function by short-term resistance training (RT). Thirty-one healthy young men measured the maximum voluntary isometric contraction (MVC) of knee extensor, electrically evoked knee extension torque, and mean arterial pressure (MAP). Then, participants were divided into three groups with matching MVC: shower without bathing (control, n = 10), thermoneutral bathing (36°C-bathing, n = 10), and hot bathing (40°C-bathing, n = 11), and conducted 2 weeks of HBBI. Following familiarization for HBBI, participants completed 2 weeks of HBBI and acute RT (five sessions of three sets of 10 isometric knee extension at 60% MVC). Baseline neuromuscular and cardiovascular function was assessed again following completion of the 2 weeks of intervention. MVC was non-significantly increased after the RT period in 40°C-bathing with large effect size (partial η2 = 0.450). The electrically evoked knee extension torque (10/100-Hz ratio) was significantly increased after the RT period in control (p = 0.020). MAP did not alter due to bathing intervention and RT (all p > 0.05). HBBI improved muscle strength without RT-induced alteration of peripheral muscle condition. Shower without bathing reduced muscle strength gain but increased peripheral muscle condition. Short-term RT does not adversely affect the cardiovascular function, regardless of HBBI.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70188"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining the predictors for post renal transplant left ventricular dysfunction in end-stage renal disease patients.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70198

Mahboobeh Sheikhani, Hoorak Poorzand, Mahnaz Ahmadi, Negar Morovatdar, Sara Afshar, Zahra Shahinfar

{"title":"Defining the predictors for post renal transplant left ventricular dysfunction in end-stage renal disease patients.","authors":"Mahboobeh Sheikhani, Hoorak Poorzand, Mahnaz Ahmadi, Negar Morovatdar, Sara Afshar, Zahra Shahinfar","doi":"10.14814/phy2.70198","DOIUrl":"10.14814/phy2.70198","url":null,"abstract":"Reduced left ventricular (LV) function predicts poor outcomes in end-stage renal disease (ESRD). This study aimed to identify the pre-renal transplantation echocardiographic parameters that can predict post-renal transplantation LV failure. This prospective longitudinal study was conducted on patients with ESRD who underwent renal transplantation during 1 year. All patients underwent echocardiography, including ejection fraction (EF), global longitudinal strain (GLS), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic diameter (LVEDD), interventricular septal (IVS) thickness, peak velocity of early diastolic transmitral flow (E), peak velocity of late transmitral flow (A), early diastolic myocardial relaxation (Em), E/A, E/Em, Left atrial volume (LAV) index, tricuspid regurgitation peak gradient (TRPG), systolic pulmonary artery pressure (SPAP), tricuspid annular plane systolic excursion (TAPSE), 1 week before and 1 month after renal transplantation. Fifty patients participated in the current study. All echocardiographic parameters improved after transplantation. Post-renal transplantation LV dysfunction was observed in 21 (42%) patients. Pre-renal transplantation echocardiographic parameters (LVEDV, LVESD, LVEDD, IVS, E/Em, TRPG, SPAP, and LAV index) could predict post-transplantation LV failure with high accuracy (AUC: 0.978).","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70198"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70232

Lokesh Sharma, Ravineel B Singh, Caden Ngeow, Rick van der Geest, Alexis M Duray, Nathanial J Tolman, Bryan J McVerry, Charles S Dela Cruz, John F Alcorn, William Bain, Keven M Robinson

{"title":"Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.","authors":"Lokesh Sharma, Ravineel B Singh, Caden Ngeow, Rick van der Geest, Alexis M Duray, Nathanial J Tolman, Bryan J McVerry, Charles S Dela Cruz, John F Alcorn, William Bain, Keven M Robinson","doi":"10.14814/phy2.70232","DOIUrl":"10.14814/phy2.70232","url":null,"abstract":"Influenza infections are often complicated by secondary bacterial infections such as MRSA pneumonia, which increase morbidity and mortality. Viral infections lead to an inflammatory response that includes elevated levels of IL-6 and interferons. IL-6 activates the JAK/STAT signaling pathway, amplifying downstream inflammation. Given the clinical efficacy of the JAK inhibitor baricitinib in reducing disease severity in COVID-19, we evaluated its impact in a murine model of influenza, MRSA, and post-influenza MRSA pneumonia. Additionally, because IL-6 inhibitory therapies have improved outcomes during COVID-19, we evaluated the impact of IL-6 deletion on post-influenza MRSA pneumonia. In our studies, baricitinib effectively inhibited the JAK/STAT pathway in the lungs, as demonstrated by decreased interferon-stimulated genes (ISGs) and STAT3 phosphorylation. Despite this inhibition, baricitinib did not cause a global suppression of cytokines. Notably, baricitinib treatment did not impair either antiviral or antibacterial host immunity, inflammatory cell recruitment, or lung tissue injury. IL-6 deficiency did not alter weight loss, inflammatory cell recruitment, or bacterial burden during post-influenza MRSA pneumonia. These findings suggest that both JAK inhibition via baricitinib and IL-6 deletion do not enhance host defense or limit tissue injury in murine models of influenza and post-influenza MRSA pneumonia.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70232"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70206

Mario Parstorfer, Gernot Poschet, Kirsten Brüning, Birgit Friedmann-Bette

{"title":"Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.","authors":"Mario Parstorfer, Gernot Poschet, Kirsten Brüning, Birgit Friedmann-Bette","doi":"10.14814/phy2.70206","DOIUrl":"10.14814/phy2.70206","url":null,"abstract":"Little is known about the exercise-induced adaptations of the metabolome in endurance and strength athletes in comparison with sedentary subjects. In order to analyze exercise-induced effects, quantitative, targeted metabolomics (Biocrates MxP® Quant 500) were performed in plasma samples before and after one bout of endurance or resistance exercise (RE) in 12 strength-trained weightlifters (ST), 10 endurance-trained runners (ET) and 12 sedentary controls (CG) at the end of each of three characteristic training phases. Performance and anthropometric data were significantly different between CG and athletes. A significant exercise-induced increase in lactate (Lac) was observed in all groups after all exercise tests. After endurance exercise (EE), there were significant increases in acetylcarnitine, arachidonic acid, and docosahexaenoic acid in CG and ET while aconitic acid, hippuric acid, glutamate, hexoses, xanthine were significantly increased in ET only. Only CG showed increases in several triglycerides following EE. RE, however, induced significant increases in Lac only. In summary, EE induces distinct increases in some metabolites of the fatty acid metabolism and the oxidative defense system in ET and CG. There are some indications for specific adaptations of the energy metabolism after long lasting endurance training with a distinct exercise-induced response of the metabolome in ET.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70206"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response of dorsal horn neurons in mice to high-frequency (kHz) biphasic stimulation is not sensitive to local temperature rise.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70205

Sergei Karnup, Stephanie Daugherty, Changfeng Tai, Naoki Yoshimura

{"title":"Response of dorsal horn neurons in mice to high-frequency (kHz) biphasic stimulation is not sensitive to local temperature rise.","authors":"Sergei Karnup, Stephanie Daugherty, Changfeng Tai, Naoki Yoshimura","doi":"10.14814/phy2.70205","DOIUrl":"10.14814/phy2.70205","url":null,"abstract":"Clinically accepted for treatment of chronic pain 10 kHz-frequency electric spinal cord stimulation (10 kHz-SCS) releases more power in tissue compared to conventional low-frequency (<100 Hz) stimulation due to increased duty cycle. This is equivalent to the release of more heat in a surrounding tissue, which may change the functional state of affected neural elements. In the case of SCS, plausible candidates to be affected by thermal a component of kHz-frequency electric field stimulation (kHz-FS) are dorsal column axons and neurons of the superficial layers of the dorsal horn. In this study, we tested the hypothesis that joule heat produced by kHz-FS modulates neuronal excitability. In slices of the mouse spinal cord, we monitored membrane potential and membrane input resistance in neurons of lamina II during exposure to kHz-FS. Surprisingly, we found no correlation between temperature rise and changes of membrane parameters. Furthermore, the depolarizing effect of kHz-FS was always immediate and remained persistent throughout stimulation, whereas rise of temperature was delayed for 1-2 s and reached its saturation level within the following few seconds. Thus, we concluded that the thermal component has an insignificant role in the mechanism of kHz-FS action.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70205"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute night shift work is associated with increased blood pressure and reduced sleep duration in healthy adults.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70231

Sophie L Seward, Erin E Kishman, Corey A Rynders, Josiane L Broussard

{"title":"Acute night shift work is associated with increased blood pressure and reduced sleep duration in healthy adults.","authors":"Sophie L Seward, Erin E Kishman, Corey A Rynders, Josiane L Broussard","doi":"10.14814/phy2.70231","DOIUrl":"10.14814/phy2.70231","url":null,"abstract":"Shift workers have a 40% higher risk for cardiovascular disease (CVD) compared to people who work day shifts. However, the acute impact of shift work on CVD risk factors in free-living settings remains unclear. We therefore investigated the impact of acute night shift work on factors related to cardiovascular health including blood pressure (BP) and sleep duration. Twenty-four rotating shift workers (19F, 23 ± 4 y, BMI: 23 ± 3 kg/m2; mean ± SD) participated in a quasi-randomized crossover study. Assessments were conducted over the course of 1 day shift and one night shift in a free-living setting. BP was measured every 30 min by an ambulatory monitor. Sleep and wake times were recorded. Mixed effects models were conducted to examine changes in variables between conditions. Acute night shift work was associated with significantly higher 24 h systolic (107 ± 1 vs. 104 ± 1 mmHg; p < 0.0001) and diastolic (67 ± 1 vs. 64 ± 1 mmHg; p < 0.0001) BP, as well as blunted dipping patterns in systolic BP (8 ± 1 vs. 12 ± 1%; p = 0.032), as compared to day shift work. Sleep duration was significantly shorter during the night shift as compared to the day shift (4 h 04 ± 19 min vs. 8 h 22 ± 18 min; p < 0.0001). As little as one night of shift work in a free-living setting is sufficient to induce multiple CVD risk factors including increased BP and reduced sleep duration in healthy adults. It is critical to identify strategies to prevent or attenuate the negative impact of shift work on CVD risk in a large portion of the working population.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70231"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the therapeutic potential of vagus nerve stimulation in autoimmune diseases: A systematic review.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70230

Eubi Chan, Ali R Mani

{"title":"Assessing the therapeutic potential of vagus nerve stimulation in autoimmune diseases: A systematic review.","authors":"Eubi Chan, Ali R Mani","doi":"10.14814/phy2.70230","DOIUrl":"10.14814/phy2.70230","url":null,"abstract":"Emerging evidence suggests that the vagus nerve can modulate the immune system in experimental settings. Vagus nerve stimulation (VNS), initially developed for managing epilepsy, is now being explored as a treatment for autoimmune diseases due to its potential immunomodulatory effects. This systematic review evaluates the therapeutic potential of VNS in autoimmune diseases by critically appraising findings from human clinical studies. This systematic review was conducted in accordance with the PRISMA guideline, with a comprehensive literature search performed in Ovid, Cochrane, and PubMed databases up to July 2024. Studies focusing on VNS in patients with autoimmune diseases were eligible, and the quality of study was assessed using the QualSyst tool. Of the 53 papers identified for full-text assessment, 19 studies met the eligibility criteria. Findings suggest that VNS is a promising adjunctive therapy for Crohn's disease and rheumatoid arthritis, showing potential to alleviate symptoms and modulate immune responses. The efficacy and safety of VNS vary widely across studies, highlighting the complex nature of autoimmune diseases and the diverse mechanisms of VNS action. Future research should prioritize large-scale, randomized controlled trials with standardized protocols to further elucidate the efficacy, long-term safety, and optimal parameters of VNS across various autoimmune conditions.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70230"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of home-based exercise with or without a Mediterranean-style diet on adiposity markers in postmenopausal women: A randomized-control trial.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70239

Abbigail Tan, Gareth Dunseath, Rebecca L Thomas, Sarah L Prior, Richard M Bracken, Rachel Churm

{"title":"Effect of home-based exercise with or without a Mediterranean-style diet on adiposity markers in postmenopausal women: A randomized-control trial.","authors":"Abbigail Tan, Gareth Dunseath, Rebecca L Thomas, Sarah L Prior, Richard M Bracken, Rachel Churm","doi":"10.14814/phy2.70239","DOIUrl":"10.14814/phy2.70239","url":null,"abstract":"Advancing age and estrogen deficiency increases susceptibility of post-menopausal women (PMW) to abdominal obesity and manifestation of cardiometabolic disease. There is limited evidence on the effect of lifestyle interventions on adiposity markers within at-risk PMW. Therefore, this study aims to evaluates an 8-weeks of home-based, equipment-free, interval training (HEFIT) with or without Mediterranean-style diet (MD) on adiposity markers in physically inactive, postmenopausal women with overweight/obesity. Thirty PMW (56.7 ± 3.9 years, BMI: 30.5 ± 5.2 kg/m2) were randomly assigned to three groups: (i) Ex; HEFIT thrice weekly/week, (ii) EX + MD, or (iii) CTL; control. Visceral Adiposity Index (VAI), body weight, BMI, waist and hip circumference (WC; HC), visceral adipose tissue (VAT), total body fat percentage, leptin, and adiponectin were determined pre- and post-8-week intervention. There was no significant between group effect on VAI. Compared to CTL, a significant between group reduction was seen in weight, BMI, and WC in both EX and EX+D (p < 0.05). Leptin and adiponectin remained unchanged in all groups (p > 0.05). Adherence rates were 85% and 96% for EX and EX+MD, respectively, and 80% of EX+D of participants had optimal adherence to diet. Concluding HEFIT with or without dietary changes could improve adiposity in overweight/obese postmenopausal women.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70239"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0