Physiological Reports最新文献_第2页

Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70305

Thomas Beiter, Gunnar Erz, Anna Würden, Andreas M Nieß

{"title":"Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes.","authors":"Thomas Beiter, Gunnar Erz, Anna Würden, Andreas M Nieß","doi":"10.14814/phy2.70305","DOIUrl":"10.14814/phy2.70305","url":null,"abstract":"In the present study, we aimed to determine the effect of moderate ambient heat stress on exercise-provoked patterns of \"leaky gut\" biomarkers and stress markers in well-trained athletes. Eleven triathletes performed a strenuous 1-h treadmill run, both under normal ambient conditions (N, 18-21°C) as well as under moderate heat environmental conditions (H, 28-30°C). Core body temperature (Tc), heart rate (HR), and rating of perceived exertion (RPE) significantly increased under both conditions, with significantly higher values during and after the H run. We observed a significant main effect of acute exercise on circulating leukocyte numbers, release of cell-free human DNA (cfDNA) but not bacterial DNA (bacDNA), and on plasma levels of intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide-binding protein (LBP), endotoxin (LPS), and D-lactate. Exercising under H conditions accelerated the mobilization of circulating neutrophils and lymphocytes, and significantly affected the release of cfDNA, D-lactate, I-FABP, creatinine, and blood potassium levels. Multiple correlation analysis revealed a significant association between Tc, max and exercise-provoked release of cfDNA (r = 0.583, p = 0.012) as well as with I-FABP (r = 0.554, p = 0.026). Our data indicate that acute exercising and heat stress may not only affect paracellular but also transcellular intestinal permeability.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70305"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring lung mechanics in patients with COPD using the handheld portable rapid expiratory occlusion monitor (REOM): A cross-sectional study.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70307

Felix-Antoine Coutu, Dany Malaeb, Olivia C Iorio, Seyedfakhreddin Nabavi, Tom McFarland, Lennart K A Lundblad, Ron J Dandurand, Stewart B Gottfried, Bryan A Ross

{"title":"Measuring lung mechanics in patients with COPD using the handheld portable rapid expiratory occlusion monitor (REOM): A cross-sectional study.","authors":"Felix-Antoine Coutu, Dany Malaeb, Olivia C Iorio, Seyedfakhreddin Nabavi, Tom McFarland, Lennart K A Lundblad, Ron J Dandurand, Stewart B Gottfried, Bryan A Ross","doi":"10.14814/phy2.70307","DOIUrl":"10.14814/phy2.70307","url":null,"abstract":"While conventional spirometry is associated with strenuous \"forced\" maximal respiratory maneuvers and infection control implications, oscillometry is not associated with these issues. However, portability, convenience of use, and interpretation remain common limitations to both techniques. This study tested the concordance and agreement between resistance measurements obtained from the handheld portable REOM device (Reo-f, Reo-s) with those from conventional oscillometry (R19, R5) in PFT-confirmed \"mild\" (GOLD 1) and \"very severe\" (GOLD 4) COPD. Unadjusted and adjusted concordance (Spearman correlation) and agreement (Bland-Altman tests) served as co-primary outcomes. Discrimination between GOLD 1 and 4 COPD (Wilcoxon rank sum test, Support Vector Machine (SVM) classifier) and patient user experience (System Utility Scale (SUS), Participant Satisfaction Survey (PSS)) served as secondary outcomes. In 17 participants (GOLD 1 n = 9, GOLD 4 n = 8), adjusted R5-Reo-s (0.95 [0.81, 0.98]) and R19-Reo-f (0.93 [0.79, 0.99]) correlations were very strong, as was agreement (mean differences: -0.07, 0.08, respectively). Statistically significant between-group differences were observed for all four resistance parameters. Reo-s in particular exhibited perfect discrimination between GOLD 1 and 4 disease, with some minor misclassification by Reo-f, R5 (n = 1 each) and R19 (n = 4). User experience scores were excellent. These results support the capacity for REOM as a novel, complementary diagnostic device in COPD.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70307"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in kidney functions following acute infusion of low molecular weight polyvinylpyrrolidone in male rats.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70295

Qi Yan, Qingshang Yan, Henry Shen, Tong Wang

{"title":"Changes in kidney functions following acute infusion of low molecular weight polyvinylpyrrolidone in male rats.","authors":"Qi Yan, Qingshang Yan, Henry Shen, Tong Wang","doi":"10.14814/phy2.70295","DOIUrl":"https://doi.org/10.14814/phy2.70295","url":null,"abstract":"Polyvinylpyrrolidone (PVP), a water-soluble homopolymer, has been widely used in food, beverage, medical, and experimental tissue preparations. However, the effect of PVP on renal functions remains unknown. We investigated the acute administration of low MW of PVP on renal functions and whether it produces a toxic effect on the kidney. Renal clearance experiments were performed in rats and showed PVP infusion elicited significant diuretic and natriuretic effects. Urine volume, absolute (ENa), and fractional (FENa) Na+ excretion were significantly increased. A relatively small kaliuretic effect was also observed. After 2 h of PVP infusion, blood urea nitrogen (BUN) and urinary concentrations of beta-N-glucosaminidase (NAG) did not change significantly. Alpha-1-microglobulin, an indicator of proximal tubule absorption ability, excretion increased 12-fold, indicating that a large portion of the fluid and Na+ loss is due to reduced absorption in the proximal tubule. The 24-fold increase in ENa and the 12-fold increase in α1-microglobulin excretion suggest that fluid and electrolyte absorption were also reduced in other nephron segments. We conclude that acute low molecular weight PVP infusion produces diuretic and natriuretic effects due to the osmotically induced reduction of proximal tubular absorption, and acute PVP infusion does not cause renal damage.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70295"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of circulating exosomal microRNAs in an LPS-induced depression model of male mice: Potential role in the anti-depressive effects of acupuncture. LPS诱导的雄性小鼠抑郁模型中循环外泌体microRNA的变化：针灸在抗抑郁作用中的潜在作用

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70310

Jade Heejae Ko, Ka Yoon Chun, Seung-Nam Kim

{"title":"Alterations of circulating exosomal microRNAs in an LPS-induced depression model of male mice: Potential role in the anti-depressive effects of acupuncture.","authors":"Jade Heejae Ko, Ka Yoon Chun, Seung-Nam Kim","doi":"10.14814/phy2.70310","DOIUrl":"10.14814/phy2.70310","url":null,"abstract":"Depression is a prevalent psychological disorder frequently associated with neuroinflammation, and microRNAs (miRNAs) have been implicated in its pathogenesis. Acupuncture, widely used in East Asia, has shown efficacy in various neuropsychiatric conditions; however, its miRNA-related mechanisms remain unclear. Using an LPS-induced depression model, we examined acupuncture's effects on depression-like behaviors and circulating exosomal miRNAs in serum. Microarray data revealed multiple miRNAs significantly altered by LPS or acupuncture, and subsequent bioinformatics analyses (TargetScan, KEGG, and Gene Ontology) identified pathways related to neuroinflammation, synaptic signaling, and circadian regulation. Constructing a miRNA-target gene network further suggested that acupuncture might modulate miRNA expression to alleviate depressive symptoms. These findings not only support the therapeutic potential of acupuncture but also propose candidate exosomal miRNAs as novel biomarkers or diagnostic tools for the LPS-induced depression model. Overall, this study provides insights into the anti-inflammatory actions of acupuncture in depression through miRNA-mediated gene regulation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70310"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subtherapeutic lithium supplementation causes physiological eccentric cardiac hypertrophy in young-adult wild-type male mice.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70299

Sophie I Hamstra, Mia S Geromella, Peter Tiidus, Panagiota Klentrou, Rebecca E K MacPherson, Val A Fajardo

{"title":"Subtherapeutic lithium supplementation causes physiological eccentric cardiac hypertrophy in young-adult wild-type male mice.","authors":"Sophie I Hamstra, Mia S Geromella, Peter Tiidus, Panagiota Klentrou, Rebecca E K MacPherson, Val A Fajardo","doi":"10.14814/phy2.70299","DOIUrl":"10.14814/phy2.70299","url":null,"abstract":"Six weeks of low-dose lithium (Li) supplementation has been shown to improve the activity of cardiac sarco(endo)plasmic reticulum calcium (Ca2+)-ATPase (SERCA) in C57BL/6J wild-type (WT) male mice. Improvements in myocardial SERCA function can lead to improvements in systolic and diastolic function in various rodent models. In this study, we tested the hypothesis that 12 weeks of subtherapeutic Li supplementation (10 mg/kg/day) would enhance SERCA function and positively influence cardiac contractility and morphology. Cardiac function and morphology were assessed using high-frequency ultrasound in the final week of Li treatment. Subsequently, SERCA activity, Ca2+ uptake assays, and Western blotting for glycogen synthase kinase-3β, SERCA2, and its inhibitor phospholamban (PLN) were performed on isolated left ventricle tissue. After 12 weeks of subtherapeutic Li supplementation, the heart underwent eccentric remodeling, exhibited by increased left ventricle internal diameter and volumes during systole and diastole, ultimately leading to greater stroke volume. However, we did not find any specific alterations in systolic or diastolic functional measures; nor were there any changes in SERCA activity and its content relative to PLN after Li supplementation. Thus, while Li supplementation appears to positively influence cardiac morphology to increase stroke volume, these changes are independent of changes to SERCA function.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70299"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Rho inhibitors on membrane depolarization-induced contraction of male rat caudal arterial smooth muscle.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70293

Kazuki Aida, Reiko Ishii-Nozawa, Mitsuo Mita

{"title":"Effects of Rho inhibitors on membrane depolarization-induced contraction of male rat caudal arterial smooth muscle.","authors":"Kazuki Aida, Reiko Ishii-Nozawa, Mitsuo Mita","doi":"10.14814/phy2.70293","DOIUrl":"10.14814/phy2.70293","url":null,"abstract":"We previously reported that depolarization of the vascular smooth muscle plasma membrane activates the Ca2+-dependent proline-rich tyrosine kinase 2 (Pyk2) upstream of the RhoA/Rho-associated kinase (ROCK) pathway, leading to phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase (MYPT1) and the 20 kDa light chain of myosin (LC20). However, the mechanism whereby Pyk2 activates RhoA remains unclear. It is conceivable that Rho guanine nucleotide exchange factors (RhoGEFs) may link activated Pyk2 to RhoA activation through phosphorylation and activation of RhoGEFs. In this study, we investigated the activation of RhoA and RhoGEFs in membrane depolarization-induced contraction of rat caudal arterial smooth muscle. Rhosin, a RhoA inhibitor, concentration-dependently inhibited both the phasic and tonic components of the 60 mM K+-induced contraction, and the inhibition was particularly prominent in the tonic contraction. On the contrary, Y16, a RhoGEF inhibitor, had little inhibitory effect. Moreover, phosphorylation of MYPT1 was increased at Thr697 and Thr855 by 60 mM K+ stimulation for 15 min, and this increase in MYPT1 phosphorylation was inhibited in the presence of Rhosin, but not Y16. We conclude that Pyk2 activated in response to Ca2+ entry induced by depolarization may cause activation of Y16-insensitive RhoGEFs and RhoA, resulting in sustained contraction.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70293"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effects of rosmarinic acid on ovarian tissue, inflammatory markers, and sex hormones in polycystic ovary syndrome rats.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70304

Sina Vakili, Farhad Koohpeyma, Mohammad Samare-Najaf, Bahia Namavar Jahromi, Morteza Jafarinia, Sepide Goharitaban, Amir Savardashtaki, Ali Samareh, Fatemeh Amini, Mohammad Hashem Hashempur

{"title":"Investigating the effects of rosmarinic acid on ovarian tissue, inflammatory markers, and sex hormones in polycystic ovary syndrome rats.","authors":"Sina Vakili, Farhad Koohpeyma, Mohammad Samare-Najaf, Bahia Namavar Jahromi, Morteza Jafarinia, Sepide Goharitaban, Amir Savardashtaki, Ali Samareh, Fatemeh Amini, Mohammad Hashem Hashempur","doi":"10.14814/phy2.70304","DOIUrl":"10.14814/phy2.70304","url":null,"abstract":"Polycystic ovary syndrome (PCOS) causes the impairment of female fertility and elevates the risk of metabolic disorders. The current study aimed to evaluate the effects of rosmarinic acid (Ros) on the ovarian histo-stereology, the level of reproductive hormones, and inflammation in a rat model of PCOS. Fifteen adult Sprague Dawley rats were randomly divided into three groups, including controls, PCOS, and PCOS+Ros (receiving 25 mg/kg of Ros for 39 days). After treatments, the ovarian histo-stereology, the level of reproductive hormones, and the level of inflammatory markers were analyzed. PCOS led to increased ovarian weight and volume, cortical and medullary expansion, reduced ovarian follicles, and enhanced follicular atresia. It also caused hormonal imbalances, elevating LH, FSH, and testosterone while decreasing estradiol, progesterone, and AMH. Additionally, PCOS increased pro-inflammatory markers (TNF-α and IL-6) and decreased anti-inflammatory markers (IL-4 and IL-10). However, Ros administration in PCOS animals improved ovarian structure, increased follicle numbers, reduced atresia, balanced reproductive hormones, and restored inflammatory markers (p value <0.05). The present findings may suggest Ros as a novel strategy for the management of PCOS, although further studies are necessary.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70304"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise ventilatory efficiency in elite athletes assessed for the Paris 2024 Olympic Games: The effect of sex and sport categories.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70261

Maria Rosaria Squeo, Ilaria Menichini, Matteo Morviducci, Alessandro Spinelli, Giuseppe Di Gioia, Viviana Maestrini, J Alberto Neder, Paolo Palange

{"title":"Exercise ventilatory efficiency in elite athletes assessed for the Paris 2024 Olympic Games: The effect of sex and sport categories.","authors":"Maria Rosaria Squeo, Ilaria Menichini, Matteo Morviducci, Alessandro Spinelli, Giuseppe Di Gioia, Viviana Maestrini, J Alberto Neder, Paolo Palange","doi":"10.14814/phy2.70261","DOIUrl":"10.14814/phy2.70261","url":null,"abstract":"Ventilatory efficiency during cardiopulmonary exercise testing (CPET) is obtained by relating minute ventilation (V'E) to CO2 output (V'CO2). Limited information is available regarding exercise ventilatory efficiency in young elite athletes. We assessed ventilatory efficiency in elite athletes; evaluating the influence of sex and/or ESC sport categories; evaluating the agreement between the V'E/V'CO2 slope and nadir in measuring ventilatory efficiency; evaluating differences between subgroups of athletes stratified by ventilatory efficiency. A cohort of 443 elite athletes prospectively underwent CPET. The slope (s1) and the intercept of the linear region of the V'E/V'CO2 relationship, the V'E/V'CO2 value at the lactate threshold and the V'E/V'CO2 nadir were used to assess ventilatory efficiency. Male athletes and endurance athletes, both males and females, had higher exercise ventilatory efficiency (p < 0.001). A strong positive correlation was observed between V'E/V'CO2 s1 and nadir (p < 0.001). Of note, both high (V'E/V'CO2 s1 < 24) and very high (V'E/V'CO2 s1 < 22) levels of ventilatory efficiency were associated with greater exercise tolerance (i.e., peak oxygen uptake, maximal power; p < 0.001). The results of our study emphasize the need to include the measurement of ventilatory efficiency in the evaluation of elite athletes, potentially refining their training strategies.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70261"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel mouse model of diverse tumors derived from epithelial cells.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70289

Bin Wang, Lingxiang Wang, Yang Liu, Yasmin Jahan-Mihan, Gordon He, Yuxi Wang, Jie Hu, Jiale Wang, Yan Bi, Baoan Ji

引用次数: 0

Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice.

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70217

Helen Goodluck, Alice Zemljic-Harpf, Ony Araujo Galdino, Sadhana Kanoo, Natalia Lopez, Young Chul Kim, Volker Vallon

{"title":"Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice.","authors":"Helen Goodluck, Alice Zemljic-Harpf, Ony Araujo Galdino, Sadhana Kanoo, Natalia Lopez, Young Chul Kim, Volker Vallon","doi":"10.14814/phy2.70217","DOIUrl":"10.14814/phy2.70217","url":null,"abstract":"Dual inhibition of sodium glucose cotransporters 1 and 2 (SGLT1/SGLT2) by sotagliflozin protects the kidney and heart in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). To gain mechanistic insights, the current study aimed to establish a murine model of hypertensive CKD that shows cardio-renal protection by sotagliflozin. Since protection by SGLT2 inhibitors can be diabetes-independent, a nondiabetic murine model of subtotal nephrectomy with angiotensin II infusion-facilitated hypertension was followed for 7 weeks. The model showed 40% lower GFR, doubling in plasma FGF23, 50 mmHg higher systolic blood pressure (SBP), 100-fold increased albuminuria, and robust signs of kidney injury, inflammation, and fibrosis versus sham controls, associated with a 30% larger left cardiac ventricle and wall thickness and upregulation of markers of cardiac overload and fibrosis. Sotagliflozin, initiated 1 week after the last surgery, showed target-engagement evidenced by glucosuria, 9 mmHg lower SBP, temporal reduction in body weight and GFR, and 30% higher plasma GLP1. Sotagliflozin, however, did not improve markers of kidney injury, inflammation, fibrosis, albuminuria, and plasma FGF23, or signs of cardiac overload, fibrosis, or impaired function. Limited sotagliflozin responsiveness may relate to short treatment time, limited metabolic benefits in nondiabetic setting and/or the model's dominant angiotensin II-driven effects/hypertension.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70217"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0