Physiological Reports最新文献_第2页

Respiratory regulation and lung volume during aquatic and land-based exercise in healthy Young adults. 健康青年在水上和陆上运动期间的呼吸调节和肺容量。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70564

Daisuke Hoshi, Marina Fukuie, Tsubasa Tomoto, Wenxing Qin, Takashi Tarumi, Jun Sugawara, Koichi Watanabe

{"title":"Respiratory regulation and lung volume during aquatic and land-based exercise in healthy Young adults.","authors":"Daisuke Hoshi, Marina Fukuie, Tsubasa Tomoto, Wenxing Qin, Takashi Tarumi, Jun Sugawara, Koichi Watanabe","doi":"10.14814/phy2.70564","DOIUrl":"10.14814/phy2.70564","url":null,"abstract":"Elevated hydrostatic pressure during water immersion reduces lung volume and compliance at rest. These alterations may persist during exercise, influencing both the respiratory regulation and lung volume. This study compared respiratory regulation and lung volume between land-based (LC) and aquatic (AC) cycling matched for oxygen uptake (VO2). Ten healthy young adults underwent cycling at low and moderate intensities in both environments. Expiratory gas variables (VO2) and respiratory variables (minute ventilation and respiratory rate: VE and RR, respectively) were continuously measured using a breath-by-breath gas analyzer system. Ventilatory equivalent for VO2 (VE/VO2) was calculated. Using a spirometry system, expiratory and inspiratory reserve volumes (ERV and IRV, respectively), and tidal volume (VT) were measured at rest and at each exercise intensity using inspiratory maneuvers and normalized to forced vital capacity (FVC). Although VO2 was matched between conditions (p > 0.05), AC resulted in significantly higher VE, RR, and consequently VE/VO2 at moderate intensity. Additionally, ERV was lower and IRV was higher during AC compared with LC across all intensities, while FVCs remained unchanged in both conditions. These findings suggest a potential mechanism by which exercise in an aquatic environment may be more effective than land-based exercise for training the respiratory system.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70564"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults. 在成人自行车运动中，组胺受体阻断不影响重-重区域边界和重-重区域的任务失败时间。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70587

Kieran S S Abbotts, Jake H Hudgins, Isabella S Viveros, Christopher T Minson, Brad W Wilkins, John R Halliwill

{"title":"Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults.","authors":"Kieran S S Abbotts, Jake H Hudgins, Isabella S Viveros, Christopher T Minson, Brad W Wilkins, John R Halliwill","doi":"10.14814/phy2.70587","DOIUrl":"10.14814/phy2.70587","url":null,"abstract":"The influence of histamine in skeletal muscle during exercise is poorly characterized. This investigation tested the hypothesis that histamine-receptor blockade lowers the power associated with the heavy-severe domain boundary and reduces time to task failure in the severe domain. Following a graded exercise test and a familiarization trial, 17 participants (8 M/9 F, 29 ± 8 years, VO2peak 60.0 ± 7.5 mL/kg/min, mean ± SD) completed cycle ergometer exercise on two separate occasions, after either histamine-receptor blockade or placebo, in a double-blind randomized crossover protocol. Exercise intensities were designed to span the moderate, heavy, and severe domains. Skeletal muscle tissue oxygen saturation (%SmO2, via near-infrared spectroscopy) and expired gases were measured continuously throughout exercise. There were no differences between blockade and placebo in power associated with the heavy-severe domain boundary (216 [195, 236] vs. 213 [191, 234] W, mean [95% CI]; p = 0.41) or time to task failure (474 [377, 572] vs. 473 [380, 566] s; p = 0.95). %SmO2 slope decreased, and oxygen uptake increased with intensity (p < 0.01), but were not affected by blockade (all p > 0.05). These findings suggest that histamine is not crucial to supporting power at the heavy-severe domain boundary or short-duration exercise in the severe domain.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70587"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of right ventricular pacing on mitochondrial function in adults. 成人右心室起搏对线粒体功能的影响。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70568

Pawut Gumrai, Teerapat Nantsupawat, Nattayaporn Apaijai, Arintaya Phrommintikul, Narawudt Prasertwitayakij, Siriporn C Chattipakorn, Nipon Chattipakorn, Wanwarang Wongcharoen

{"title":"Influence of right ventricular pacing on mitochondrial function in adults.","authors":"Pawut Gumrai, Teerapat Nantsupawat, Nattayaporn Apaijai, Arintaya Phrommintikul, Narawudt Prasertwitayakij, Siriporn C Chattipakorn, Nipon Chattipakorn, Wanwarang Wongcharoen","doi":"10.14814/phy2.70568","DOIUrl":"10.14814/phy2.70568","url":null,"abstract":"Right ventricular pacing (RVP) frequency and duration significantly associate with RVP-induced cardiomyopathy. However, human data regarding RVP burden and mitochondrial function is scarce. We aimed to investigate the association between the duration and percentage of RVP and mitochondrial function in the peripheral blood mononuclear cells (PBMCs). This cross-sectional study enrolled individuals with a permanent pacemaker device with RVP capabilities, implanted for over 1 month, and exhibiting preserved left ventricular (LV) systolic function. The assessment of mitochondrial function was conducted using PBMCs to explore its correlation with RVP burden since pacemaker implantation. The analysis included 96 patients. The majority of patients had advanced or third-degree atrioventricular block, with a median RVP percentage of 84% and a median duration since implantation was 64 months. Substantial RVP percentage (RVP ≥ 40%) was independently associated with increased cellular oxidative stress (p = 0.015). Patients with longer RVP exposure (duration since implantation ≥ 60 months) were independently associated with increased mitochondrial oxidative stress (p = 0.030). Both associations remained significant after adjusting for confounding variables. In individuals with permanent pacemaker and preserved LV systolic function, substantial RVP percentage and prolonged RVP exposure were independently associated with increased cellular and mitochondrial oxidative stress.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70568"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat acclimation prevents neurobehavioral and physiological disorders in mice exposed to chronic aircraft noise. 热适应可预防暴露于慢性飞机噪音的小鼠的神经行为和生理紊乱。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70575

Kangli Zhang, Xiaojing Lin, Ching-Ping Chang, Xueqing Yi, Wei Wu, M J Walker, Qingjian Ding, Kai Liu, Chuanning Sun, Yanping Sun, Zhongya Shi, Cheng-Hsien Lin, Gang Sun

{"title":"Heat acclimation prevents neurobehavioral and physiological disorders in mice exposed to chronic aircraft noise.","authors":"Kangli Zhang, Xiaojing Lin, Ching-Ping Chang, Xueqing Yi, Wei Wu, M J Walker, Qingjian Ding, Kai Liu, Chuanning Sun, Yanping Sun, Zhongya Shi, Cheng-Hsien Lin, Gang Sun","doi":"10.14814/phy2.70575","DOIUrl":"10.14814/phy2.70575","url":null,"abstract":"We aimed to test whether heat acclimation (HA) would protect against aircraft noise (AN)-induced neurobehavioral and physiological disorders in mice. A total of 90 adult male mice were equally divided into three groups: control (c) plus non-AN group, c plus AN group, and HA plus AN group. Neurobehavioral performances included passive avoidance tasks (to assess learning and memory function), Y-maze tests (to assess spatial memory ability), and novel object recognition tests. Physiological functions included stress responses, inflammation, and oxidative stress, which were determined biochemically. The severity of endotoxemia was determined by measuring the serum levels of lipopolysaccharide. Both gut barrier and blood-brain barrier permeability were determined by fluorescein isothiocyanate and Evans Blue dye measurement, respectively. Compared to c+non-AN mice, the c+AN mice displayed neurobehavioral disorders along with exacerbated stress reactions, gut barrier disruption, endotoxemia, blood-brain barrier disruption, and hippocampal inflammation and oxidative stress. Compared to c+AN mice, the HA+AN mice had significantly less severity of all the abovementioned behavioral and physiological impairments. These results suggest that HA counteracts neurobehavioral and physiological disorders in mice exposed to aircraft noise.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70575"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between muscle sympathetic nerve activity and red blood cell distribution width in adults. 成人肌肉交感神经活动与红细胞分布宽度的关系。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70577

Gavin W Lambert, Carolina Ika Sari, Nora E Straznicky, John B Dixon, Nina Eikelis, Murray D Esler, Markus P Schlaich, Elisabeth A Lambert

{"title":"Association between muscle sympathetic nerve activity and red blood cell distribution width in adults.","authors":"Gavin W Lambert, Carolina Ika Sari, Nora E Straznicky, John B Dixon, Nina Eikelis, Murray D Esler, Markus P Schlaich, Elisabeth A Lambert","doi":"10.14814/phy2.70577","DOIUrl":"10.14814/phy2.70577","url":null,"abstract":"Measures obtained from the full blood count have been shown to vary around a set point, are stable over years, and provide an indication of disease risk and mortality. In this study, we examined the association between sympathetic nerve activity and components of the full blood count. We performed a retrospective analysis of data drawn from our clinical database. Subjects were included if available data comprised full blood count and muscle sympathetic nerve activity (MSNA). Data were obtained from 160 individuals, comprising healthy volunteers, subjects who were overweight or with clinical obesity, and patients with high blood pressure. MSNA was correlated to the red cell distribution width (RDW, Spearman's rho 0.49 for MSNA b/min and 0.48 for MSNA b/100hb, p < 0.001 for both), but bore no association with any of the other blood variables. Regression analysis indicated that the RDW could be predicted by a combination of MSNA and BMI and to the number of components and diagnosis of the metabolic syndrome, measures of insulin resistance, and markers of inflammation. Our observations may provide insight into the possible mechanisms linking the RDW with mortality.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70577"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of acute ketone monoester ingestion on heart rate, blood pressure and muscle sympathetic nerve activity at rest and stress in healthy adults. 急性单酯酮摄入对健康成人静息和应激时心率、血压和肌肉交感神经活动的影响

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70584

Erin Seto, Massimo Nardone, Johan S Thiessen, André L Teixeira, Julian C Bommarito, Gaetano C Pocchi, Devin G McCarthy, Philip J Millar

{"title":"Effects of acute ketone monoester ingestion on heart rate, blood pressure and muscle sympathetic nerve activity at rest and stress in healthy adults.","authors":"Erin Seto, Massimo Nardone, Johan S Thiessen, André L Teixeira, Julian C Bommarito, Gaetano C Pocchi, Devin G McCarthy, Philip J Millar","doi":"10.14814/phy2.70584","DOIUrl":"10.14814/phy2.70584","url":null,"abstract":"Exogenous ketone supplementation can impact cardiovascular regulation, but the effects on muscle sympathetic nerve activity (MSNA) remain unknown. In a randomized, crossover, double-blind design, 19 participants (23 ± 4 years.; female: n = 9) ingested an oral ketone monoester (KME; 0.4 g/kg) or isocaloric, isovolumetric placebo. Blood pressure, heart rate, brachial artery blood flow, and MSNA (microneurography; n = 14) were assessed at rest before and after ingestion and during two laboratory stressors: 2-min static handgrip exercise and 2-min of mental arithmetic. Capillary β-hydroxybutyrate increased 20 and 40 min post KME ingestion versus placebo (both, p < 0.001). Compared to placebo, KME had no effects on resting mean arterial pressure (Placebo: 78.3 ± 9.3 to 80.2 ± 10.5 mmHg; KME: 76.3 ± 8.3 to 79.5 ± 8.8 mmHg; interaction p = 0.32), heart rate (Placebo: 64.6 ± 12.3 to 69.6 ± 11.0 bpm; KME: 65.3 ± 10.6 to 72.6 ± 11.3 bpm; interaction p = 0.30), or MSNA burst frequency (Placebo: 17.7 ± 7.3 to 17.7 ± 6.7 bursts/minute; KME: 17.5 ± 6.1 to 18.2 ± 7.0 bursts/minute; interaction p = 0.72). Resting brachial artery blood flow and vascular conductance changed over time but did not differ between conditions (interactions, both p > 0.40). Neuro-cardiovascular responses during exercise (interactions, all p > 0.72) or mental stress (interactions, all p > 0.44) did not differ between conditions. Compared to placebo, acute KME ingestion did not modulate neuro-cardiovascular measures at rest or during stress in healthy young adults.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70584"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic signature of short-term low energy availability. 短期低能量可利用性的代谢特征。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70582

Valentin Nusser, Chaise Murphy, Sieglinde Hechenbichler Figueroa, Alexander Braunsperger, Johanna K Ihalainen, Juha J Hulmi, Paulina Wasserfurth, Karsten Koehler

{"title":"Metabolic signature of short-term low energy availability.","authors":"Valentin Nusser, Chaise Murphy, Sieglinde Hechenbichler Figueroa, Alexander Braunsperger, Johanna K Ihalainen, Juha J Hulmi, Paulina Wasserfurth, Karsten Koehler","doi":"10.14814/phy2.70582","DOIUrl":"10.14814/phy2.70582","url":null,"abstract":"Exposure to low energy availability (LEA) can potentially detrimentally affect athletes' health and performance. Timely identification is crucial, yet its detection is often delayed until severe symptoms emerge. Our objective was to identify characteristic differences in the serum metabolome as potential early LEA biomarkers. We performed large-scale metabolomics analyses of data from two highly controlled, randomized controlled trials, exposing trained adults to short-term (3-5 days) low or high energy availability (15 (LEA) versus 40 (HEA) kcal·kg FFM-1·day-1), which were achieved once with and once without daily aerobic exercise. Differences between LEA and HEA were prominent in triglycerides (0.66 ± 0.22 vs. 1.07 ± 0.47 mmol·L-1), total fatty acids (9.46 ± 1.50 vs. 11.22 ± 2.59 mmol·L-1), amino acids (e.g., alanine: 0.46 ± 0.10 vs. 0.58 ± 0.15 mmol·L-1), very-low-density lipoproteins (0.57 ± 0.23 vs. 0.67 ± 0.25 mmol·L-1), and ketone bodies (e.g., β-hydroxybutyrate: 364 ± 241 vs. 30 ± 17 μmol·L-1; all FDR < 0.05). These patterns reveal a marked shift towards increased fat utilization, altered lipoprotein profiles, and enhanced ketogenesis in response to short-term LEA. Post-intervention β-hydroxybutyrate (>0.09 mmol·L-1) best predicted LEA, regardless of whether LEA was achieved with or without exercise, supporting its candidacy for LEA screening. Overall, our findings provide new insight into the metabolomic signature of LEA and support metabolomics as a tool for early detection of LEA.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70582"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of high-intensity interval training and alternative modalities for enhancing aerobic and anaerobic endurance in young athletes. 高强度间歇训练和替代训练方式对提高年轻运动员有氧和无氧耐力的meta分析。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70598

Manuel Matzka, Mascha Lenk, Benedikt Meixner, Billy Sperlich

{"title":"Meta-analysis of high-intensity interval training and alternative modalities for enhancing aerobic and anaerobic endurance in young athletes.","authors":"Manuel Matzka, Mascha Lenk, Benedikt Meixner, Billy Sperlich","doi":"10.14814/phy2.70598","DOIUrl":"10.14814/phy2.70598","url":null,"abstract":"This meta-analysis examined whether HIIT outperforms low-intensity endurance training (LIET), generic training (GT), or sport-specific drills (SSD) in improving aerobic and anaerobic endurance in youth athletes. Systematic searches of PubMed, MEDLINE, SPORTDiscus, and Web of Science identified studies comparing HIIT with LIET, GT, or SSD in athletes aged ≤18 years. Outcomes included maximal oxygen uptake (VO2max), continuous endurance, intermittent endurance, and repeated sprint ability. Random-effects meta-analyses computed standardized mean differences, with risk of bias and sensitivity analyses conducted. Twenty-eight studies (N = 707, 10.7% female) met inclusion criteria. HIIT elicited significantly greater VO2max improvements than GT (g = 0.97; p < 0.01) and also surpassed GT for continuous endurance performance (g = 0.91; p < 0.01). Compared to LIET, HIIT achieved similar VO2max and continuous endurance outcomes despite less total training time. Against SSD, HIIT improved continuous endurance performance more (g = 0.41; p = 0.02), while showing no difference in VO2max, intermittent endurance, or repeated sprint ability. HIIT is an effective, time-efficient modality for enhancing aerobic capacity and continuous endurance performance in youth athletes. It outperforms GT and is at least as effective as LIET and SSD. Coaches should consider incorporating HIIT into youth training programs to optimize endurance adaptations within limited training time. Future research should investigate long-term effects, consider female representation, and evaluate distinct HIIT protocols to further refine evidence-based training guidelines.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70598"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of 2-h hypoxic exposure on resting hepcidin levels in young adults. 2小时缺氧暴露对年轻成人静息hepcidin水平的影响。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70530

Chao-An Lin, Masatoshi Naruse, Chihiro Tomiishi, Hikaru Matsudo, Claire E Badenhorst, Kazushige Goto

{"title":"Effect of 2-h hypoxic exposure on resting hepcidin levels in young adults.","authors":"Chao-An Lin, Masatoshi Naruse, Chihiro Tomiishi, Hikaru Matsudo, Claire E Badenhorst, Kazushige Goto","doi":"10.14814/phy2.70530","DOIUrl":"https://doi.org/10.14814/phy2.70530","url":null,"abstract":"We evaluated the effects of acute hypoxic exposure on serum hepcidin levels. In a crossover design, 11 healthy individuals (9 men and 2 women) completed a 2-h period of seated rest in a hypoxic (HYP; fraction of inspired oxygen [FiO2]: 12.5%) or normoxic control (CON; FiO2: 20.9%) environment in the morning. Following the environmental exposure, participants rested in a CON environment for 6 h. Venous blood samples were collected at baseline, immediately post-exposure, and at 2-, 4-, and 6-h post-exposure. Serum erythropoietin (EPO) levels increased significantly over time in both conditions (p < 0.05). At 2-h post-exposure, the EPO response was significantly greater in HYP than in CON (p < 0.05). Serum erythroferrone (ERFE) levels did not differ significantly between the HYP and CON trials at any time point. Serum hepcidin levels increased significantly at 4- and 6-h post-exposure in both trials compared to baseline (p < 0.05). However, no significant differences in serum hepcidin levels were observed between the HYP and CON trials at any time point. These findings suggest that a 2-h hypoxic exposure enhances the erythropoietic response in young adults but does not suppress diurnal serum hepcidin or elevate ERFE levels.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 19","pages":"e70530"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of FGF21-inducing rare sugars that reduces sugar appetite in male BL/6 mice. fgf21诱导的降低雄性BL/6小鼠糖食欲的稀有糖的鉴定。

IF 2.2

Physiological Reports Pub Date : 2025-10-01 DOI: 10.14814/phy2.70618

Oulan G H N B Efendi, Sho Matsui, Satoshi Tsuzuki, Tsutomu Sasaki

引用次数: 0