Physiological Reports最新文献_第2页

ML-UrineQuant: A machine learning program for identifying and quantifying mouse urine on absorbent paper.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70243

Warren G Hill, Bryce MacIver, Gary A Churchill, Mariana G DeOliveira, Mark L Zeidel, Marcelo Cicconet

引用次数: 0

Reliability of popliteal artery flow-mediated dilation in the seated position.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70252

Taskina Akhter, Patrick B Wilson, J David Branch, Leryn J Reynolds

{"title":"Reliability of popliteal artery flow-mediated dilation in the seated position.","authors":"Taskina Akhter, Patrick B Wilson, J David Branch, Leryn J Reynolds","doi":"10.14814/phy2.70252","DOIUrl":"https://doi.org/10.14814/phy2.70252","url":null,"abstract":"Flow-mediated dilation (FMD), a noninvasive measure of endothelial function, is commonly measured in the popliteal artery in the supine and upright body positions. However, reliability studies of the measurement in these positions are not well studied. This study aimed to examine the trial-retrial and visit-to-visit reliability of popliteal artery FMD in the seated position. Popliteal artery FMD was measured in 20 healthy adults across two visits in the seated and prone positions to assess visit-to-visit reliability. Two measurements were taken for each body position at each visit to assess trial-retrial reliability. %FMD was calculated as the percent change from baseline diameter to peak diameter. The reliability of FMD was assessed via the intraclass correlation coefficient (ICC). Popliteal artery %FMD shows moderate-to-good reliability in the seated position (ICC: 0.67-0.89) and poor-to-moderate reliability in the prone position (ICC: 0.25-0.74) within and between visits. There were no significant differences in baseline diameter or minimum diameter between body positions, visits, or trials (p > 0.05). %FMD and peak diameter following cuff deflation demonstrated no significant difference between body positions (p > 0.05). Popliteal artery FMD demonstrates good reliability in the seated position, supporting the development of a standardized measurement protocol.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70252"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70277

Muneeb Iqbal, Edward Bliss, Eliza J Whiteside, Ben Hoffman, Dean E Mills

{"title":"The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men.","authors":"Muneeb Iqbal, Edward Bliss, Eliza J Whiteside, Ben Hoffman, Dean E Mills","doi":"10.14814/phy2.70277","DOIUrl":"https://doi.org/10.14814/phy2.70277","url":null,"abstract":"High-intensity exercise hyperpnea places substantial demands upon the respiratory muscles, but whether this causes respiratory muscle damage is unknown. We investigated respiratory muscle damage following volitional hyperpnea (equivalent to 85% of participants maximum minute ventilation produced during a maximal incremental cycling test) using a skeletal muscle damage biomarker panel. Eight healthy men (33 + 2 years) underwent 10-min trials of volitional hyperpnea and rest (control) two weeks apart. Serum was collected before and at 1, 24, and 48 h after both volitional hyperpnea and control trials. Creatine kinase muscle-type (CKM), fast skeletal troponin I (sTnI) and slow sTnI were measured using enzyme-linked immunosorbent assay. Two-way analysis of variance revealed time × trial interaction effects for slow sTnI (p = 0.018), but not for CKM (p = 0.072) and fast sTnI (p = 0.140). Slow sTnI was significantly higher at +24 h post volitional hyperpnea (p < 0.001) as compared to the same time point of the control trial. These results indicate that high-intensity exercise hyperpnea may induce a small amount of respiratory muscle damage as evidenced by the increases in slow sTnI. Future studies including more time points, different respiratory muscle exercise protocols, and examining the differences between sexes could provide additional insights into the utility of blood biomarkers for identifying respiratory muscle damage.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70277"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70142

Simon Lui, Arash Tadjalli, Jimmy Fraigne, John Peever

{"title":"Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.","authors":"Simon Lui, Arash Tadjalli, Jimmy Fraigne, John Peever","doi":"10.14814/phy2.70142","DOIUrl":"10.14814/phy2.70142","url":null,"abstract":"The respiratory control system can exhibit neuronal plasticity following exposures to repetitive respiratory challenges. For example, repeated obstructive apneas can trigger a form of respiratory plasticity that results in the enhancement of inspiratory hypoglossal (XII) motoneuron activity. This increase in respiratory motor output is known as hypoglossal long-term facilitation (hLTF). In adult male Sprague-Dawley rats, we demonstrate that hLTF can also be triggered in the absence of repeated apneas by intermittent optogenetic stimulation of locus coeruleus (LC) neurons, or through pharmacological activation of adenosine-A2a-receptors at the level of brainstem XII motor pool. Both our pharmacological and optogenetic approaches that trigger hLTF require noradrenergic signaling through activation of α1-noradrenergic receptors on hypoglossal motoneurons. We also use optical LC inhibition to reaffirm the importance of the LC in mediating apnea-induced hLTF. These results demonstrate that hLTF can be triggered by multiple hypoxia-independent stimuli, and for the first time, identify the LC as a key brainstem source for noradrenaline necessary for the expression of hLTF.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70142"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis-a pilot study in adult patients.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70179

Fansan Zhu, Laura Rosales Merlo, Lela Tisdale, Maricar Villarama, Jun Yi, Zahin Haq, Xiaoling Wang, Nadja Grobe, Karsten Fischer, Kulwinder Plahey, Richard A Lasher, Paul Chamney, Brigitte Schiller, Peter Kotanko

{"title":"Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis-a pilot study in adult patients.","authors":"Fansan Zhu, Laura Rosales Merlo, Lela Tisdale, Maricar Villarama, Jun Yi, Zahin Haq, Xiaoling Wang, Nadja Grobe, Karsten Fischer, Kulwinder Plahey, Richard A Lasher, Paul Chamney, Brigitte Schiller, Peter Kotanko","doi":"10.14814/phy2.70179","DOIUrl":"10.14814/phy2.70179","url":null,"abstract":"Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2-h dwell using 2 L of dialysate containing 2.5% dextrose. IPP was measured using a pressure sensor integrated into an automated PD cycler. IPV was monitored concurrently by segmental bioimpedance (Hydra 4200). The density (ρ) of the PD dialysate was measured using a meter, and the creatinine and glucose concentrations in both dialysate (D) and serum (P) were measured pre- and post-PD dwell. A physical model (IPP = ρ × g × h), was used to describe the relationship between IPP and IPV, where h is the apparent dialysate height and g is the gravitational acceleration. The change in IPP (ΔIPP, -21.2 ± 18%) was mainly determined by the change of h (Δh, -20.9 ± 18.5%), while the change ρ (Δρ, -0.34 ± 0.06%), was minor. The study demonstrated an association between ΔIPP and the ratio of D/P creatinine and D/D0 glucose, suggesting that ΔIPP may reflect membrane transport characteristics. Due to its noninvasive and seamless nature, the clinical utility of PD cycler-based measurement of IPP warrants further exploration.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70179"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological shear stress suppresses apoptosis in human pulmonary microvascular endothelial cells.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70269

Simin Yan, Nicolas M Philip, Samuel T Murray, Xin Yun, Michael P Croglio, Karthik Suresh, Mahendra Damarla, Larissa A Shimoda, Todd M Kolb

{"title":"Physiological shear stress suppresses apoptosis in human pulmonary microvascular endothelial cells.","authors":"Simin Yan, Nicolas M Philip, Samuel T Murray, Xin Yun, Michael P Croglio, Karthik Suresh, Mahendra Damarla, Larissa A Shimoda, Todd M Kolb","doi":"10.14814/phy2.70269","DOIUrl":"https://doi.org/10.14814/phy2.70269","url":null,"abstract":"Physiological shear stress contributes to maintaining endothelial cell homeostasis, including suppression of apoptosis. In the pulmonary circulation, diseases such as pulmonary embolism and pulmonary hypertension result in alterations in shear stress. Shear stress has been reported to suppress endothelial apoptosis through phosphatidylinositol 3-kinase (PI3K) activation, but evidence from human pulmonary microvascular endothelial cells (PMVECs) is lacking. We hypothesized that physiological shear stress activates PI3K to reduce apoptosis in human PMVECs. We utilized the orbital shaker model of shear stress to test our hypothesis. Apoptosis was evaluated by measuring chromatin condensation, caspase 3/7 activity, and DNA fragmentation. We found that shear stress caused a rapid and sustained increase in protein kinase B (Akt) phosphorylation, a surrogate for activated PI3K, in human PMVECs. Under static conditions, PI3K inhibition with LY294002 or challenge with the kinase inhibitor staurosporine (STS) induced apoptosis in PMVECs. Following exposure to shear stress for 24 h, LY294002- and STS-induced apoptosis was reduced. The anti-apoptotic effect of shear stress in STS-challenged cells was reversed by PI3K inhibition. We conclude that physiological shear stress increases PI3K/Akt activity and suppresses apoptosis in normal human PMVECs.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70269"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation into the sex dependence of post-reperfusion cardiac mitochondrial function and redox balance in chronically stressed rats.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70185

Megan Cairns, Jasmine Andrews, Caitlin Odendaal, Cassidy O'Brien, Erna Marais, Gerald Maarman, Balindiwe Sishi, Danzil Joseph, Fanie Rautenbach, Jeanine L Marnewick, M Faadiel Essop

{"title":"An investigation into the sex dependence of post-reperfusion cardiac mitochondrial function and redox balance in chronically stressed rats.","authors":"Megan Cairns, Jasmine Andrews, Caitlin Odendaal, Cassidy O'Brien, Erna Marais, Gerald Maarman, Balindiwe Sishi, Danzil Joseph, Fanie Rautenbach, Jeanine L Marnewick, M Faadiel Essop","doi":"10.14814/phy2.70185","DOIUrl":"10.14814/phy2.70185","url":null,"abstract":"Although mitochondrial alterations are implicated in cardiac pathologies, sex-specific changes following chronic stress and ischemia-reperfusion injury are poorly characterized. Male and female Wistar rats underwent chronic restraint stress (CRS) for 4 weeks versus controls, whereafter ex vivo hearts were subjected to regional ischemia and reperfusion. Post-reperfusion hearts were dissected into ischemia-reperfused and non-ischemic regions with high-resolution mitochondrial respirometry, and oxidative stress assays performed. CRS males displayed increased routine and fatty acid β-oxidation respiration in non-ischemic tissues but lowered ETF-linked LEAK contributions to overall electron transfer system capacity ratios in ischemia-reperfused regions versus controls. CRS males exhibited lowered superoxide dismutase activity and increased lipid peroxidation in well-perfused regions versus controls. Female CRS hearts showed attenuated ETF-linked LEAK respiration and increased lipid peroxidation versus controls in non-ischemic tissue but a lowered RE ratio (measure of mitochondrial coupling) with ischemia-reperfusion. Our findings highlight the heart's sexually dimorphic response to chronic stress and ischemic injury, with female hearts showing oxidative damage in non-ischemic tissues together with relatively intact mitochondrial function in ischemia-reperfused tissues.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70185"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11859663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response of VO_2max to dark chocolate consumption in healthy subjects: A systematic review and meta-analysis of randomized controlled trials.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70256

Aref Mehdipour, Saber Saedmocheshi, Giuseppe Potrick Stefani, Ehsan Amiri, Diako Heidary

{"title":"Response of VO2max to dark chocolate consumption in healthy subjects: A systematic review and meta-analysis of randomized controlled trials.","authors":"Aref Mehdipour, Saber Saedmocheshi, Giuseppe Potrick Stefani, Ehsan Amiri, Diako Heidary","doi":"10.14814/phy2.70256","DOIUrl":"10.14814/phy2.70256","url":null,"abstract":"The potential role of dark chocolate (DC) in enhancing exercise performance remains underexplored. While DC has been associated with various health benefits, its specific impact on endurance performance, particularly VO2max, has not been conclusively established. This meta-analysis examined the effect of DC on VO2max in healthy individuals using PRISMA guidelines. Following the application of inclusion and exclusion criteria, five randomized controlled trials (RCTs) involving 144 participants were included, with VO2max as the primary outcome. The meta-analysis revealed no significant effect of DC on VO2max (SMD = 0.14, 95% CI: -0.16 to 0.44, p = 0.36). Heterogeneity among the studies was low (Q-value = 3.34, I2 = 0.00, p = 0.50), and sensitivity analysis confirmed the robustness of the findings, as excluding individual studies did not alter the results (SMD = 0.14, 95% CI: -0.16 to 0.44, p = 0.36). In conclusion, this meta-analysis suggests that DC consumption does not significantly improve VO2max in healthy individuals. Future research should explore the effects of DC on other aspects of exercise performance, as well as its long-term impact, to better understand its potential role in athletic and health-related outcomes.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70256"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11859664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestine. 小鼠急性簇细胞消减会诱发吸收不良以及小肠分泌和免疫细胞系的改变。

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70264

Michael Momoh, Francisca Adeniran, Cynthia Ramos, Kathleen E DelGiorno, Hiroshi Seno, Joseph T Roland, Izumi Kaji

{"title":"Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestine.","authors":"Michael Momoh, Francisca Adeniran, Cynthia Ramos, Kathleen E DelGiorno, Hiroshi Seno, Joseph T Roland, Izumi Kaji","doi":"10.14814/phy2.70264","DOIUrl":"10.14814/phy2.70264","url":null,"abstract":"Intestinal tuft cells have recently been the focus of many studies due to their function in chemosensation and type 2 immunity in human gastrointestinal diseases. This study investigated the impact of acute tuft cell loss on intestinal physiological function. Tuft cell deletion was induced in DCLK1-IRES-GFP-CreERT2/+;Rosa-DTA (DCLK1-DTA) mice by a single tamoxifen injection, concomitant with littermate controls. Transient deletion of intestinal and biliary tuft cells was maximal on day 4 and recovered by day 7 post tamoxifen. DCLK1-DTA mice presented with significantly shortened small intestinal length and greater body weight loss by day 4. The activity of Na+-dependent glucose transporter 1 (SGLT1) and cystic fibrosis transmembrane regulator (CFTR) was reduced. Correlated with tuft cell reduction, the frequency of cholecystokinin (CCK)+ enteroendocrine and intermediate secretory cells, which co-express Paneth and goblet cell markers, was increased. In the lamina propria, fewer mast cells and leukocytes were found in the Day 4 DCLK1-DTA mice compared to controls. Ablation of tuft cells may induce nutrient malabsorption through alterations in epithelial cell proliferation and differentiation, along with changes in the mucosal defense response. These observations identify a new role for tuft cells in regulating intestinal absorption and mucosal regeneration.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70264"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high-fat diet-induced obese and prediabetic mice.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70276

Cameron P McCall, Melina C Mancini, Jaroslaw Staszkiewicz, Douglas G Mashek, Timothy D Heden

{"title":"Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high-fat diet-induced obese and prediabetic mice.","authors":"Cameron P McCall, Melina C Mancini, Jaroslaw Staszkiewicz, Douglas G Mashek, Timothy D Heden","doi":"10.14814/phy2.70276","DOIUrl":"https://doi.org/10.14814/phy2.70276","url":null,"abstract":"Glycophagy is the autophagic degradation of glycogen by the enzyme acid alpha-glucosidase (GAA). Although GAA inhibitors improve metabolic health by inhibiting GAA in the intestine, it is not clear if GAA inhibition in peripheral tissues such as the liver is metabolically beneficial. This study tested if the heterozygous knockout of GAA (HetKO-GAA) alters liver metabolism and metabolic health in mice fed a low-fat diet or a high-fat diet to induce obesity. HetKO-GAA mice fed either diet did not have altered body weight, glucose tolerance, insulin action, energy expenditure, substrate metabolism, liver glucose output, or liver triglycerides compared to control wildtype mice. A liver spatial transcriptomics analysis revealed that high-fat diet feeding reduced the gene abundance of predominantly metabolic pathways in both periportal and perivenous hepatocytes, and uniquely reduced ribosome gene abundance in perivenous hepatocytes. HetKO-GAA mice did not have significantly altered transcriptomes in periportal or perivenous hepatocytes compared to wildtype mice. In conclusion, heterozygous GAA knockout is nonconsequential on metabolism and metabolic health in high-fat diet induced obesity. Spatial transcriptomics revealed alterations in the transcriptome of periportal and perivenous hepatocytes from high-fat diet induced obese mice, highlighting novel targets that could be exploited to improve metabolic health in obesity.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70276"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0