Physiological Reports最新文献_第2页

miRNA-1 regulation is necessary for mechanical overload-induced muscle hypertrophy in male mice. miRNA-1调控是雄性小鼠机械负荷引起的肌肉肥大所必需的。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70166

Shengyi Fei, Blake D Rule, Joshua S Godwin, C Brooks Mobley, Michael D Roberts, Ferdinand von Walden, Ivan J Vechetti

{"title":"miRNA-1 regulation is necessary for mechanical overload-induced muscle hypertrophy in male mice.","authors":"Shengyi Fei, Blake D Rule, Joshua S Godwin, C Brooks Mobley, Michael D Roberts, Ferdinand von Walden, Ivan J Vechetti","doi":"10.14814/phy2.70166","DOIUrl":"https://doi.org/10.14814/phy2.70166","url":null,"abstract":"MicroRNAs (miRNAs) are small, noncoding RNAs that play a critical role in regulating gene expression post-transcriptionally. They are involved in various developmental and physiological processes, and their dysregulation is linked to various diseases. Skeletal muscle-specific miRNAs, including miR-1, play a crucial role in the development and maintenance of skeletal muscle. It has been demonstrated that the expression of miR-1 decreases by approximately 50% in response to hypertrophic stimuli, suggesting its potential involvement in muscle hypertrophy. In our study, we hypothesize that reduction of miR-1 levels is necessary for skeletal muscle growth due to its interaction to essential pro-growth genes. Promoting a smaller reduction of miR-1 levels, we observed a blunted hypertrophic response in mice undergoing a murine model of muscle hypertrophy. In addition, our results suggest that miR-1 inhibits the expression of Itm2a, a membrane-related protein, as potential miR-1-related candidate for skeletal muscle hypertrophy. While the exact mechanism in muscle hypertrophy has not been identified, our results suggest that miR-1-regulated membrane proteins are important for skeletal muscle hypertrophy.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70166"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of a combined long-duration static stretching and resistance training regimen on a competitive bodybuilder: A case study. 结合长时间静态拉伸和阻力训练方案对竞技健美运动员的影响：一个案例研究。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70156

Kai A Homer, Eric R Helms, Alyssa-Joy Spence

{"title":"The effect of a combined long-duration static stretching and resistance training regimen on a competitive bodybuilder: A case study.","authors":"Kai A Homer, Eric R Helms, Alyssa-Joy Spence","doi":"10.14814/phy2.70156","DOIUrl":"https://doi.org/10.14814/phy2.70156","url":null,"abstract":"Both resistance training (RT) and long-duration, high-intensity stretching induce muscular adaptations; however, it is unknown whether the modalities are complementary or redundant, particularly in well-trained individuals. A case-study was conducted on a competitive bodybuilder implementing long-duration, high-intensity stretching of the plantar flexors (60 min 6x/week for 12 weeks) in conjunction with their habitual RT. Ultrasound muscle architecture (muscle thickness [MT], fascicle length [FL], and pennation angle [PA]) measurements were collected at multiple sites at four weekly baseline sessions, six (mid) and 12 (post1) weeks following the commencement of the intervention, and a week after the intervention (post2) while isometric strength and range of motion (RoM) were obtained once at baseline, mid, post1, and post2. 2SD band plots were constructed to determine meaningful changes in MT, FL, and PA from the four baseline measures while percentage and absolute change across each timepoint were calculated for all variables. From baseline to post 1, RoM, strength, and MT increased 25.9%, 11.4%, and 7.4%-23.4%, respectively, while four MT and two PA sites exceeded the threshold for meaningful change. The combined stretching and RT protocols resulted in flexibility, strength, and MT adaptations; however, findings should be generalized with caution given the case-study nature of our investigation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 2","pages":"e70156"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs. 在铜绿假单胞菌诱导的母猪脓毒症模型中，脂肪和肌肉组织分解对器官间能量底物通量的作用。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70129

Ryan Morse, Gabriella A M Ten Have, John J Thaden, Marielle P K J Engelen, Sarah Rice, Martin Hagve, Nicolaas E P Deutz

{"title":"The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs.","authors":"Ryan Morse, Gabriella A M Ten Have, John J Thaden, Marielle P K J Engelen, Sarah Rice, Martin Hagve, Nicolaas E P Deutz","doi":"10.14814/phy2.70129","DOIUrl":"https://doi.org/10.14814/phy2.70129","url":null,"abstract":"Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis. In a translational porcine model of sepsis, we explored the across organ net fluxes of gluconeogenic substrates. In 13 pigs, acute sepsis was induced by IV infusion of Pseudomonas aeruginosa, while in 9 pigs saline (control) was given for 18 h. Blood samples were collected between 12 and 18 h and analyzed with HPLC and LCMS. In sepsis, glucose plasma concentration was reduced (p = 0.0028). A concordant increase in splanchnic area net release of glucose (p = 0.0049), due to reduced uptake in the portal drained viscera (PDV) (p = 0.0032) with an unchanged liver production (p = 0.7861). The hindquarter showed a higher release of alanine (p = 0.0002), glutamine (p = 0.003), and lactate (p = 0.0007), but not for glycerol (p = 0.5718). Diminished PDV uptake of gluconeogenic amino acids, increased liver uptake of these substrates (p < 0.05), while no change in liver glycerol uptake (p = 0.3170), did not lead to an increased net liver glucose release. In the acute phase of sepsis, we hypothesize an important role of altered intestinal amino acid metabolism and breakdown of muscle proteins, but not of glycolysis to support gluconeogenesis.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70129"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-short-term versus short-term measures of heart rate variability in specialist police units: A pilot reliability study. 专业警察单位的超短期与短期心率变异性测量：一项试点可靠性研究。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70182

Colin D Tomes, Elisa F D Canetti, Ben Schram, Robin Orr

{"title":"Ultra-short-term versus short-term measures of heart rate variability in specialist police units: A pilot reliability study.","authors":"Colin D Tomes, Elisa F D Canetti, Ben Schram, Robin Orr","doi":"10.14814/phy2.70182","DOIUrl":"10.14814/phy2.70182","url":null,"abstract":"Police officers are exposed to high levels of stress. Serving on Special Weapons and Tactics (SWAT) teams is a highly demanding duty that may further increase levels of stress in police personnel. This stress may accumulate, thereby increasing allostatic load. As such, holistic stress measures may be valuable for quantifying multifactorial stress accumulation in SWAT personnel. Heart rate variability (HRV) is one field-deployable measure that may be suitable in this context. However, with logistical challenges present in this population, determining if 30 s; rather than more the typical 5-min ECG data collection, provides sufficient reliability may be beneficial for reducing the logistical barrier to adoption of HRV monitoring in SWAT personnel. This study compared 30-s to 5-min HRV analyses of ECG data obtained from 15 male SWAT personnel. Findings demonstrated good (ICC >0.8) reliability only in the VLF, HF, SD1, and SD2 HRV domains. The VLF and SD2 measures may be erroneous, as 5-min may still insufficiently characterize these measures. However, this study confirms the robust quality of nonlinear HRV analysis, as the SD1 value demonstrated the highest ICC reported here (0.902). Therefore, while 5-min ECGs may still preferable, the 30-s measure may still be viable for organizations considering HRV assessment.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 2","pages":"e70182"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion. 雄性小鼠种系缺失 Rgs2 和/或 Rgs5 不会加剧亚慢性异丙肾上腺素输注引起的左心室重塑。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70178

Shelby Dahlen, Ipsita Mohanty, Bo Sun, Sanjana Nallapaneni, Patrick Osei-Owusu

{"title":"Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion.","authors":"Shelby Dahlen, Ipsita Mohanty, Bo Sun, Sanjana Nallapaneni, Patrick Osei-Owusu","doi":"10.14814/phy2.70178","DOIUrl":"10.14814/phy2.70178","url":null,"abstract":"Sympathoexcitation is a hallmark of heart failure, with sustained β-adrenergic receptor (βAR)-G protein signaling activation. βAR signaling is modulated by regulator of G protein signaling (RGS) proteins. Previously, we reported that Gαi/o regulation by RGS2 or RGS5 is key to ventricular rhythm regulation, while the dual loss of both RGS proteins results in left ventricular (LV) dilatation and dysfunction. Here, we tested whether sustained βAR stimulation with isoproterenol (ISO, 30 mg/kg/day, 3 days) exacerbates LV remodeling in male mice with germline deletion of Rgs2 and/or Rgs5. Rgs2 KO and Rgs2/5 dbKO mice showed LV dilatation at baseline, which was unchanged by ISO. Rgs2 or Rgs5 deletion decreased Rgs1 expression, whereas Rgs5 deletion increased Rgs4 expression. ISO induced cardiac hypertrophy and interstitial fibrosis in Rgs2/5 dbKO mice without increasing cardiomyocyte size or LV dilation but increased expression of cardiac fetal gene Nppa, α-actinin, and Ca2+-/calmodulin-dependent kinase II. Single Rgs2 and Rgs5 KO mice had markedly increased CD45+ cells, whereas tissue from Rgs5 KO mice showed increased CD68+ cells, as revealed by immunohistochemistry. The results together indicate that ventricular remodeling due to Rgs2 and/or Rgs5 deletion is associated with augmented myocardial immune cell presence but is not exacerbated by sustained βAR stimulation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70178"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of fascial manipulation, vibration exercise, motor imagery, or neuro-muscular electrical stimulation on the coagulation system: A pilot study. 筋膜操作、振动练习、运动想象或神经肌肉电刺激对凝血系统的影响：一项初步研究。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70165

Gerhard Cvirn, Anna Hawliczek, Axel Schlagenhauf, Bianca Brix, Karin Schmid Zalaudek, Sebastian Schwaminger, Margret Paar, Willibald Wonisch, Thomas Wagner, Ziva Arko, Nandu Goswami

{"title":"Effects of fascial manipulation, vibration exercise, motor imagery, or neuro-muscular electrical stimulation on the coagulation system: A pilot study.","authors":"Gerhard Cvirn, Anna Hawliczek, Axel Schlagenhauf, Bianca Brix, Karin Schmid Zalaudek, Sebastian Schwaminger, Margret Paar, Willibald Wonisch, Thomas Wagner, Ziva Arko, Nandu Goswami","doi":"10.14814/phy2.70165","DOIUrl":"10.14814/phy2.70165","url":null,"abstract":"Available evidence suggests that various medical/rehabilitation treatments evoke multiple effects on blood hemostasis. It was therefore the aim of our study to examine whether fascial manipulation, vibration exercise, motor imagery, or neuro-muscular electrical stimulation can activate the coagulation system, and, thereby, expose patients to thrombotic risk. Ten healthy young subject were enrolled in the study. Blood samples were obtained pre and posttreatment. Besides standard laboratory methods, calibrated automated thrombography (CAT) and thrombelastometry (TEM) were used allowing sensitive detection of hyper- and hypocoagulable states. Application of fascial manipulation, motor imagery, or neuro-muscular electrical stimulation had vitually no effect whereas a single bout of vibration exercise caused significant coagulation activation. For example, TEM-derived coagulation times were significantly shortened (209 ± 34 vs. 187 ± 41 s, p = 0.0098) and CAT-derived thrombin peaks were significantly higher (235 ± 88 vs. 268 ± 82 nM, p = 0.0020) in post compared with preexercise samples. Moreover, vibration exercise, motor imagery, and neuro-muscular electrical stimulation caused significant plasma expansion (6.15%, 7.53%, and 3.88% plasma volume changes, respectively). We conclude that vibrational exercise apparently represents a potential procoagulant stimulus, and ongoing studies have to clarify whether VE should be applied particularly to patients with an elevated risk for thrombosis.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70165"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoracic load carriage impairs the acute physiological response to hypoxia in healthy males. 胸载损害健康男性对缺氧的急性生理反应。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70197

Daniel A Baur, Caroline M Lassalle, Stephanie P Kurti

{"title":"Thoracic load carriage impairs the acute physiological response to hypoxia in healthy males.","authors":"Daniel A Baur, Caroline M Lassalle, Stephanie P Kurti","doi":"10.14814/phy2.70197","DOIUrl":"10.14814/phy2.70197","url":null,"abstract":"To assess the impact of thoracic load carriage on the physiological response to exercise in hypoxia. Healthy males (n = 12) completed 3 trials consisting of 45 min walking in the following conditions: (1) unloaded normoxia (UN; FIO2:20.93%); (2) unloaded hypoxia (UH; FIO2:~13.0%); and (3) loaded hypoxia (LH; 29.5 kg; FIO2:~13.0%). Intensity was matched for absolute VO2 (2.0 ± 0.2 L·min-1) across conditions and relative VO2 (64.0 ± 2.6 %VO2max) across hypoxic conditions. With LH versus UH, there were increases in breathing frequency (5-11 breaths·min-1; p < 0.05) and decreases in tidal volume (10%-18%; p < 0.05) throughout exercise due to reductions in end inspiratory lung volumes (p < 0.05). Consequently, deadspace (11%-23%; p < 0.05) and minute ventilation (7%-11%; p < 0.05) were increased starting at 20 and 30 min, respectively. In addition, LH increased perceived exertion/dyspnea and induced inspiratory (~12%; p < 0.05 vs. UN) and expiratory (~10%; p < 0.05 vs. pre-exercise) respiratory muscle fatigue. Expiratory flow limitation was present in 50% of subjects during LH. Cardiac output and muscle oxygenation were maintained during LH despite reduced stroke volume (6%-8%; p < 0.05). Finally, cerebral oxygenated/total hemoglobin were elevated in the LH condition versus UH starting at 15 min (p < 0.05). Thoracic load carriage increases physiological strain and interferes with the compensatory response to hypoxic exposure.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70197"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Scandinavian Physiological Society in 100 years-Looking ahead. 斯堪的纳维亚生理学会100年的展望。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70181

Helle Prætorius, Vladimir Matchkov, Nanna Brinch, Tobias Wang

引用次数: 0

Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure. 褪黑素对涡虫头部再生的影响取决于暴露的时间和持续时间。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70151

Simon C Beeching, Hanna E Ruland, Katelyn M Sparks

{"title":"Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure.","authors":"Simon C Beeching, Hanna E Ruland, Katelyn M Sparks","doi":"10.14814/phy2.70151","DOIUrl":"10.14814/phy2.70151","url":null,"abstract":"Melatonin is a multifunctional biomolecule with demonstrated stimulatory, inhibitory, and antioxidant effects, including both receptor-mediated and receptor-independent mechanisms of action. One of its more perplexing effects is the disruption of regeneration in planaria. Head regeneration in planaria is a remarkable phenomenon in which stem cells (neoblasts) migrate to the wound site, proliferate, then differentiate into all functional tissue types within days of injury. We investigated how both the timing and duration of melatonin exposure affect head regeneration in the planaria Phagocata gracilis (Haldeman). Our results demonstrate that P. gracilis is capable of recovery from the melatonin-induced delay of regeneration and reveal the time required to recover to control levels. Further, we found evidence of regenerative stage-specific responses to discontinuous melatonin exposure, including non-inhibitory effects. Further exploration of melatonin's effects on regeneration can be targeted to specific regenerative processes, and the possibility of multiple mechanisms of action should be recognized.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 2","pages":"e70151"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of defined voluntary running distances coupled with high-fat diet consumption on the skeletal muscle transcriptome of male mice. 规定的自愿跑步距离加上高脂肪饮食消耗对雄性小鼠骨骼肌转录组的影响。

IF 2.2

Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70170

Afrina Brishti, Sarah J Johnson, Daniel G Palmer, Md Obayed Raihan, Lin Yan, Shanon L Casperson

{"title":"Effects of defined voluntary running distances coupled with high-fat diet consumption on the skeletal muscle transcriptome of male mice.","authors":"Afrina Brishti, Sarah J Johnson, Daniel G Palmer, Md Obayed Raihan, Lin Yan, Shanon L Casperson","doi":"10.14814/phy2.70170","DOIUrl":"10.14814/phy2.70170","url":null,"abstract":"Exercise counters many adverse health effects of consuming a high-fat diet (HFD). However, complex molecular changes that occur in skeletal muscle in response to exercising while consuming a HFD are not yet known. We investigated the interplay between diverse exercise regimes and HFD consumption on the adaptation of skeletal muscle transcriptome. C57BL/6 male mice were randomized into five groups-one sedentary control group and four exercise groups. The exercise groups consisted of an unrestricted running group (8.3 km/day) and three groups that were restricted to 75%, 50%, or 25% of unrestricted running (6.3, 4.2, and 2.1 km/day, respectively). Total RNA was extracted from frozen gastrocnemius muscle for transcriptome analyses. DEG counts were 1347, 1823, 1103, and 1107 and there were 107, 169, 67, and 89 unique genes present in the HFD-25%, HFD-50%, HFD-75%, and HFD-U, respectively. Comparing exercise groups, we found that exercising at 50% resulted in the most differentially expressed transcripts with the MAPK and PPAR signaling pathways enriched in down- and up-regulated genes, respectively. These results demonstrate that running distance impacts the adaptation of the skeletal muscle transcriptome to exercise and suggest that middle-distance running may provide the greatest protection against high-fat diet-induced stress coupled with exercise.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 2","pages":"e70170"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0