Physiological Reports最新文献_第10页

Neural indicators of sleep loss and sleep propensity in male military trainees: Insights from dry-electrode EEG-An exploratory study. 男性军事受训人员睡眠缺失和睡眠倾向的神经指标：来自干电极脑电图的见解-一项探索性研究。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70301

Jazmin Morrone, Sarah Coakley, Sam Blacker, Stephen Myers, Paul Hough, Christopher Vine, Tessa Maroni, Neil Stanley, Shona Halson, Andrew Siddall, Stephen Patterson, Martin Jones, Kieran Chillingsworth, Charles R Pedlar

{"title":"Neural indicators of sleep loss and sleep propensity in male military trainees: Insights from dry-electrode EEG-An exploratory study.","authors":"Jazmin Morrone, Sarah Coakley, Sam Blacker, Stephen Myers, Paul Hough, Christopher Vine, Tessa Maroni, Neil Stanley, Shona Halson, Andrew Siddall, Stephen Patterson, Martin Jones, Kieran Chillingsworth, Charles R Pedlar","doi":"10.14814/phy2.70301","DOIUrl":"10.14814/phy2.70301","url":null,"abstract":"This study examined the impact of reduced sleep on electroencephalogram (EEG) activity during cognitive tasks in Military Clearance Diver trainees using a novel dry-electrode EEG system. Seven male participants underwent two 5-day periods: a baseline and a \"live-in\" phase with increased workload and reduced sleep (5.4 ± 0.1 vs. 7.4 ± 0.7 h). EEG was recorded daily in the early morning (am) and late afternoon (pm) during a Psychomotor Vigilance Test (PVT), two oculography tests (am: n = 4; pm: n = 3), and 2 min of eyes-closed rest. Significant increases in theta (t (29) = 2.308, p = 0.028, d = 0.421) and alpha (t (29) = 2.124, p = 0.042, d = 0.388) power spectrum densities were observed in the \"live-in\" phase during the PVT. These findings align with increased lower frequency activity over time awake, reflecting heightened sleep propensity. Sleep loss was further confirmed by declining Odds Ratio Product (ORP) values. This study demonstrates the feasibility of dry-electrode EEG in detecting fatigue-related neural changes and highlights the potential of ORP as a quantifiable fatigue marker. These insights may inform operational settings, such as military diver performance monitoring and fatigue management strategies.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70301"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

African Americans with a family history of cardiovascular disease show lower endothelial-dependent vasodilation. 有心血管疾病家族史的非裔美国人内皮依赖性血管舒张较低。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70176

Julian F Thayer, Darcianne K Watanabe, Julia Birenbaum, Julian Koenig, Marc Jarczok, DeWayne P Williams, Gaston K Kapuku

{"title":"African Americans with a family history of cardiovascular disease show lower endothelial-dependent vasodilation.","authors":"Julian F Thayer, Darcianne K Watanabe, Julia Birenbaum, Julian Koenig, Marc Jarczok, DeWayne P Williams, Gaston K Kapuku","doi":"10.14814/phy2.70176","DOIUrl":"10.14814/phy2.70176","url":null,"abstract":"Normotensive African Americans (AAs) show attenuated vascular responses and reduced nitric oxide (NO) bioavailability compared to European Americans (EAs). Few studies have used diverse measures to examine differences in macrovascular function and structure in individuals with a family history of CV disease (CVD). We assessed 150 AAs (Mage, 23.57 ± 2.73 yr) and 104 EAs (Mage, 22.70 ± 2.86) with a confirmed family history of CVD. Age, sex, body mass index, and father's education were used as covariates, hemodynamic measures (heart-rate [HR], stroke volume [SV], cardiac output [CO], total peripheral resistance [TPR], mean arterial pressure [MAP], systolic and diastolic blood pressure [SBP/DBP], and pulse pressure [PP]), high-frequency heart-rate variability [HF-HRV], and endothelial-dependent arterial dilation [EDAD] were the dependent variables. AA's had lower EDAD (11.64 vs. 13.20%) and higher HF-HRV (7.31 vs. 7.11 ms2), TPR (17.60 vs. 15.93 mmHg/L/min), TPI (33.72 vs. 30.09 mmHg/L/min/m2), MAP (83.60 vs. 78.36 mmHg), SBP (115.44 vs. 110.23 mmHg), and DBP (65.35 vs. 60.57 mmHg). Lower EDAD alongside no ethnic differences in PP, HR, or SV suggests early onset endothelial dysfunction (lower NO availability) rather than inherited pathophysiological structural characteristics (arterial stiffness) in AAs. Future prospective studies are needed and should consider measures of sympathetic activity and potential moderators, including discrimination.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70176"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of different proximities to failure on arterial stiffness following resistance training protocols matched for volume-load. 与容量负荷相匹配的阻力训练方案对动脉僵硬度的影响。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70196

Eleftherios Karanasios, Scott Hannah, Helen Ryan-Stewart, James Faulkner

{"title":"The effect of different proximities to failure on arterial stiffness following resistance training protocols matched for volume-load.","authors":"Eleftherios Karanasios, Scott Hannah, Helen Ryan-Stewart, James Faulkner","doi":"10.14814/phy2.70196","DOIUrl":"https://doi.org/10.14814/phy2.70196","url":null,"abstract":"This study compared acute changes in measures of arterial stiffness (AS) between two resistance training (RT) protocols that were load, volume and rest matched, but differed in intensity of effort. Eleven healthy adults (36.4 ± 6.8 years) performed a RT protocol with high intensity of effort (HE) and a RT protocol with low intensity of effort (LE). The HE protocol consisted of 3 sets of 12 repetitions, while the LE comprised of 6 sets of 6 repetitions. Loading intensity, volume load, and total rest duration were equivalent between the RT sessions. Pulse wave velocity, augmentation index values collected at baseline, immediately post and 15 min post-exercise. HE elicited significantly greater increases in carotid-femoral pulse wave velocity (6.4 ± 0.3 to 7.3 ± 0.5 m/s) when compared to LE (6.6 ± 0.3 to 6.7 ± 0.3 m/s) (p < 0.05). Both HE and LE induced significant increases in augmentation index (13 ± 5.6 to 28.1 ± 9.3%) post exercise (all p < 0.05). These findings demonstrate that RT with a lower intensity of effort attenuate increases in measures of arterial stiffness compared to a RT scheme at higher intensity of effort when volume load and total rest are equalized.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70196"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA hypermethylation preceded by H3K27 trimethylation is linked to downregulation of gene expression in disuse muscle atrophy in male mice. H3K27三甲基化之前的DNA超甲基化与雄性小鼠废用性肌肉萎缩基因表达下调有关。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70317

Junya Shimizu, Fuminori Kawano

{"title":"DNA hypermethylation preceded by H3K27 trimethylation is linked to downregulation of gene expression in disuse muscle atrophy in male mice.","authors":"Junya Shimizu, Fuminori Kawano","doi":"10.14814/phy2.70317","DOIUrl":"https://doi.org/10.14814/phy2.70317","url":null,"abstract":"Disuse muscle atrophy can result in downregulated gene expression vital to muscle integrity, yet the mechanisms driving this downregulation remain unclear. Epigenetic alterations regulate transcriptional potential, with repressive changes suppressing gene expression. This study explored epigenetic mechanisms of gene downregulation during disuse muscle atrophy. Male C57BL/6J mice underwent hindlimb suspension for 3 or 7 days. The vastus intermedius (VI) muscle was analyzed, showing unchanged mass on day 3, but on day 7, decreased mass and reduced fiber size were assessed via immunohistochemistry. Corresponding to this atrophy timing, qPCR analysis revealed nine downregulated genes on day 7, which were selected for epigenetic analysis; collectively, they showed no downregulation on day 3. Among the nine genes, methylated DNA immunoprecipitation revealed significantly elevated DNA methylation (hypermethylation) in the upstream regions of transcription start sites (TSS) on day 7, which overall negatively correlated with gene expression. Histone marks (H3K27me3, H3K4me3, H3.3, and total H3) were also assessed using chromatin immunoprecipitation, revealing that the repressive histone mark H3K27me3 increased in the regions on day 3 but decreased on day 7. These findings suggest that DNA hypermethylation in the upstream regions preceded by H3K27me3 enrichment contributes to the downregulation of gene expression during disuse muscle atrophy.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70317"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unaltered maximal power and submaximal performance correlates with an oxidative vastus lateralis proteome phenotype during tapering in male cyclists. 不变的最大功率和次最大性能与氧化股外侧肌蛋白质表型在男性自行车运动员的减径。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70302

Pieter de Lange, Giuseppe Petito, Hannah L Notbohm, Antonia Giacco, Giovanni Renzone, Elena Silvestri, Arianna Cuomo, Frank Suhr, Thorsten Schiffer, Jonas Zacher, Federica Cioffi, Rosalba Senese, Andrea Scaloni, Moritz Schumann, Wilhelm Bloch

{"title":"Unaltered maximal power and submaximal performance correlates with an oxidative vastus lateralis proteome phenotype during tapering in male cyclists.","authors":"Pieter de Lange, Giuseppe Petito, Hannah L Notbohm, Antonia Giacco, Giovanni Renzone, Elena Silvestri, Arianna Cuomo, Frank Suhr, Thorsten Schiffer, Jonas Zacher, Federica Cioffi, Rosalba Senese, Andrea Scaloni, Moritz Schumann, Wilhelm Bloch","doi":"10.14814/phy2.70302","DOIUrl":"https://doi.org/10.14814/phy2.70302","url":null,"abstract":"Little is known on how a short-term reduction of training volume changes muscle proteome and physiological parameters. We investigated the impact of halving training volume during regular training of cyclists on physiological parameters in relation to vastus lateralis protein profiles and fiber percentage ratios. Fifteen male cyclists (age: 30.1 ± 9.6 yrs.; VO2max: 59.4 ± 4.4 mL∙kg-1∙min-1; weekly training volume: 8.7 ± 2.3 h) participated in an 11-week training intervention. During 2 weeks after a shared training programme for 9 weeks, a control group continued training and a taper group reduced training volume by 50%. No end-point differences were found for peak power output, maximal oxygen uptake, or peak and mean power in a sprint test (p > 0.05), although in the taper group, muscle proteins involved in mitochondrial aerobic respiration increased whereas those involved in translation, protein catabolism, and actin organization decreased, without between-group differences in type I/type II fiber percentage ratios. Tapering did not decrease power at the first (LT1) and second lactate threshold (LT2) compared to t0, whereas power increased in the control group (LT1: 216 ± 28 W vs. 238 ± 11 W, p = 0.042, LT2: 290 ± 42 W vs. 318 ± 13 W, p = 0.005). Our data indicate that transient 50% training volume reductions may be beneficial for oxidative metabolism in muscle.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 8","pages":"e70302"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise performance in well-trained male mice is promoted by intermittent hyperoxia via improving metabolic properties and capillary profiles. 间歇性高氧可通过改善代谢特性和毛细血管特征来促进训练良好的雄性小鼠的运动表现。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70341

Junichi Suzuki

{"title":"Exercise performance in well-trained male mice is promoted by intermittent hyperoxia via improving metabolic properties and capillary profiles.","authors":"Junichi Suzuki","doi":"10.14814/phy2.70341","DOIUrl":"https://doi.org/10.14814/phy2.70341","url":null,"abstract":"Although training under intermittent hyperoxia has been shown to improve exercise performance, its effect on well-trained mice remains undetermined. Voluntary run for 7 weeks increased maximal work values by 7.4-fold (Bayes factor, BF ≥ 30). Subsequently, mice underwent 4 weeks of treadmill training with (INT) or without (ET) intermittent hyperoxia (30% O2). INT training significantly increased maximal exercise capacity compared to ET (BF ≥ 30). INT group exhibited significantly higher levels of cytochrome-c-oxidase (COX) in soleus muscle (SOL, BF ≥ 3.0). Additionally, INT enhanced 3-hydroxyacyl-CoA-dehydrogenase (HAD) levels in white gastrocnemius (Gw) and plantaris (PL) muscles compared to ET (BF ≥ 3.0). Pyruvate dehydrogenase complex (PDHc) levels were significantly higher in the INT group compared to the ET group in red gastrocnemius and left ventricle (BF ≥ 30). Capillary-to-fiber ratio (C/F) was significantly higher in the INT group than in the ET group in SOL and PL muscles (BF ≥ 3.0). COX, PDHc, capillary density (CD), and catalase protein values in SOL, HAD, and C/F levels in Gw and PL, as well as CD values in Gw showed a significant positive correlation with maximal work values using data from ET and INT groups (p < 0.05). These findings suggest that training under intermittent hyperoxia promotes endurance performance probably by improving metabolic enzyme levels and capillary profiles in well-trained mice.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 8","pages":"e70341"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory effect of exercise on elevated blood pressure and fetal growth restriction during pregnancy in Dahl salt-sensitive rats. 运动对达尔盐敏感大鼠妊娠期血压升高和胎儿生长受限的抑制作用。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70298

Toru Kobayashi, Linh Thuy Pham, Mutsumi Kobayashi, Ko Yamanaka, Atsuo Itakura, Hidefumi Waki

{"title":"Inhibitory effect of exercise on elevated blood pressure and fetal growth restriction during pregnancy in Dahl salt-sensitive rats.","authors":"Toru Kobayashi, Linh Thuy Pham, Mutsumi Kobayashi, Ko Yamanaka, Atsuo Itakura, Hidefumi Waki","doi":"10.14814/phy2.70298","DOIUrl":"https://doi.org/10.14814/phy2.70298","url":null,"abstract":"Exercise is effective in preventing gestational hypertension, but its mechanism remains unclear. This study investigates the effects of exercise on Dahl salt-sensitive (DSS) rats, which develop elevated blood pressure and fetal growth restriction during pregnancy. DSS rats were divided into exercise and non-exercise groups, with Sprague-Dawley rats as controls. Exercise consisted of voluntary running, starting 4 weeks prior to pregnancy until the last trimester. Cardiovascular parameters, molecular characteristics of the brain and placenta, and fetal conditions were evaluated. Exercise significantly improved elevated blood pressure at early pregnancy and was associated with improved baroreceptor reflex gain. Gene expression analysis in the rostral ventrolateral medulla (RVLM) showed exercise-induced downregulation of nitric oxide synthase and upregulation of superoxide dismutase. These genetic changes suggest that exercise impacts circulatory regulation mechanisms, contributing to blood pressure improvement. In addition, placental analysis revealed a marked increase in placental growth factor expression due to exercise. In conclusion, exercise alleviates elevated blood pressure at early gestation and fetal growth restriction in DSS rats. Genetic modifications in the RVLM may play a critical role in exercise-induced cardiovascular improvements. This study highlights the potential of exercise as a therapeutic approach for managing gestational elevated blood pressure and fetal growth restriction and provides insights into its underlying mechanisms.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70298"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A method for determination of hematocrit using the mobile app "HaemoCalc": Validity, reliability, and effect of user expertise. 使用移动应用程序“HaemoCalc”测定红细胞压积的方法：有效性、可靠性和用户专业知识的效果。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70314

Lawrence D Hayes, Nilihan E M Sanal-Hayes, Maryam Ellam, Marie Mclaughlin, Michelle G Swainson, Nicholas F Sculthorpe

{"title":"A method for determination of hematocrit using the mobile app \"HaemoCalc\": Validity, reliability, and effect of user expertise.","authors":"Lawrence D Hayes, Nilihan E M Sanal-Hayes, Maryam Ellam, Marie Mclaughlin, Michelle G Swainson, Nicholas F Sculthorpe","doi":"10.14814/phy2.70314","DOIUrl":"https://doi.org/10.14814/phy2.70314","url":null,"abstract":"We evaluated validity, reliability, and effect of user expertise of \"HaemoCalc\", a mobile phone application for hematocrit (Hct) measurement from fingerpick blood samples, compared to a traditional Hawksley microhaematocrit reader (MHR). Experiment 1 examined the effect pitch angle during image capture exerted on the validity of Hct values. Twenty participants' samples were analyzed at 0°, 10°, and 20° directly over the sample, and 33° with a 10 cm setback. Analysis of variance (ANOVA) revealed a significant effect of angle on Hct values (p < 0.01). Measurements at 33° pitch differed from other angles and the MHR (p < 0.001, d = 2.31-3.06). Bland-Altman analysis showed good agreement at 0°, 10°, and 20° (mean differences: -0.4% to 1.0%) but poor agreement at 33° (mean difference: -4.4%, LOA: -0.7% to 8.4%). Experiment 2 assessed inter- and intra-rater reliability of expert and novice users (n = 12). Participants performed three trials each. HaemoCalc and MHR showed excellent reliability (ICC = 0.95-1.00). No differences were observed between experts and novices (p = 1.000, d = 0.01-0.39). HaemoCalc is a valid and reliable tool for Hct measurement at small pitch angles and in expert and novice users. The HaemoCalc app offers scalability, repeatability, health and safety benefits, and potential applications in medical education and remote learning.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 8","pages":"e70314"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effect of cedrol in a male rat model of Parkinson's disease. 雪松醇对帕金森病雄性大鼠模型的神经保护作用。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70309

Fatemeh Forouzanfar, Mahmoud Hosseini, Amir Mahmoud Ahmadzadeh, Ali Mohammad Pourbagher-Shahri

{"title":"Neuroprotective effect of cedrol in a male rat model of Parkinson's disease.","authors":"Fatemeh Forouzanfar, Mahmoud Hosseini, Amir Mahmoud Ahmadzadeh, Ali Mohammad Pourbagher-Shahri","doi":"10.14814/phy2.70309","DOIUrl":"10.14814/phy2.70309","url":null,"abstract":"Cedrol is a natural sesquiterpene subgroup of terpenes with antioxidant and anti-inflammatory properties. This study evaluated the effect of cedrol on the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD). Unilateral injection of 6-OHDA was performed to induce the PD model. Cedrol at 10 mg/kg and 20 mg/kg was administrated. The rotarod test, apomorphine-induced rotational test, and open field tests assessed motor function, while the passive avoidance test was used to evaluate cognitive function. Furthermore, striatal levels of malondialdehyde (MDA) and total thiol, and SOD (superoxide dismutase) activity were measured. The induction of lesion led to a significantly higher number of rotations in the apomorphine-induced rotational test, lower maintenance in the rotarod test, as well as a shorter delay for entering into and a longer duration of time spent in the dark chamber in the passive avoidance test, versus the control group. It also enhanced the striatal levels of MDA and diminished the striatal SOD activity and level of total thiol. Administration of cedrol significantly improved behavioral tests and biochemical assays. Cedrol could benefit cognitive and motor functions in a rat model of PD. Its antioxidant properties might mediate these effects.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70309"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of body composition, cardiorespiratory, and neuromuscular adaptations induced by three different high intensity training protocols. 三种不同的高强度训练方案诱导的身体组成、心肺和神经肌肉适应的比较。

IF 2.2

Physiological Reports Pub Date : 2025-04-01 DOI: 10.14814/phy2.70306

Corentin Scoubeau, Julie Carpentier, Stéphane Baudry, Vitalie Faoro, Malgorzata Klass

{"title":"Comparison of body composition, cardiorespiratory, and neuromuscular adaptations induced by three different high intensity training protocols.","authors":"Corentin Scoubeau, Julie Carpentier, Stéphane Baudry, Vitalie Faoro, Malgorzata Klass","doi":"10.14814/phy2.70306","DOIUrl":"10.14814/phy2.70306","url":null,"abstract":"This study investigated body composition, cardiorespiratory, and neuromuscular adaptations induced by three high intensity trainings easy to fit into daily routine. Thirty-seven adults participated in one of the following 8-week interventions: vigorous intensity continuous training (VICT; 28 min at 70% of peak oxygen uptake [VO2peak]), long interval high intensity interval training (LI-HIIT; 6 × 2 min at 85% VO2peak), or short interval HIIT (SI-HIIT; 12 × 30 s at 125% maximal power output). Heart rate (HR) and rating of perceived exertion (RPE) were measured during sessions. Pre- and post-intervention assessments included fat and lean mass, cardiopulmonary exercise testing, knee extensors maximal isometric torque, voluntary activation, and endurance during a submaximal contraction. Compared to SI-HIIT and VICT, LI-HIIT sessions were characterized by a shorter duration, a similar time spent above 90% HRmax, but a higher RPE (p < 0.05). VO2peak and muscle endurance increased respectively by 14% and 12%, while knee extensors torque, voluntary activation, and lean mass increased to a lesser extent (1%-3%) after the interventions (ANOVA time-effect, all p < 0.05). There was no significant difference between the modalities (intervention × time interaction, all p > 0.05). In conclusion, comparable body composition, cardiorespiratory, and neuromuscular adaptations were induced by the three high intensity training protocols, while RPE was higher during LI-HIIT sessions.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 7","pages":"e70306"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0