Physiological Reports最新文献_第10页

Age-related differences in agility are related to both muscle strength and corticospinal tract function.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70223

Evan G MacKenzie, Nick W Bray, Syed Z Raza, Caitlin J Newell, Hannah M Murphy, Michelle Ploughman

{"title":"Age-related differences in agility are related to both muscle strength and corticospinal tract function.","authors":"Evan G MacKenzie, Nick W Bray, Syed Z Raza, Caitlin J Newell, Hannah M Murphy, Michelle Ploughman","doi":"10.14814/phy2.70223","DOIUrl":"10.14814/phy2.70223","url":null,"abstract":"Agility is essential for \"healthy\" aging, but neuromuscular contributions to age-related differences in agility are not entirely understood. We recruited healthy (n = 32) non-athletes (30-84 years) to determine: (1) if aging is associated with agility and (2) whether muscle strength or corticospinal tract function predicts agility. We assessed muscle strength via a validated knee extension test, corticospinal tract function via transcranial magnetic stimulation, and agility via spatiotemporal values (i.e., leg length-adjusted hop length and hop length variability) collected during a novel propulsive bipedal hopping (agility) task on an electronic walkway. Pearson correlation revealed aging is associated with leg length-adjusted hop length (r = -0.671, p < 0.001) and hop length variability (r = 0.423, p = 0.016). Further, leg length-adjusted hop length and hop length variability correlated with quadriceps strength (r = 0.581, p < 0.001; r = -0.364, p = 0.048) and corticospinal tract function (r = -0.384, p = 0.039; r = 0.478, p = 0.007). However, hierarchical regressions indicated that, when controlling for sex, muscle strength only predicts leg length-adjusted hop length (R2 = 0.345, p = 0.002), whereas corticospinal tract function only predicts hop length variability (R2 = 0.239, p = 0.014). Therefore, weaker quadriceps decrease the distance hopped, and deteriorating corticospinal tract function increases variability in hop length.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70223"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70258

Spencer J Skaper, Brooke R Shepley, Ibrahim Amr Wafai, Philip N Ainslie, Anthony R Bain, Kurt J Smith

{"title":"Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men.","authors":"Spencer J Skaper, Brooke R Shepley, Ibrahim Amr Wafai, Philip N Ainslie, Anthony R Bain, Kurt J Smith","doi":"10.14814/phy2.70258","DOIUrl":"10.14814/phy2.70258","url":null,"abstract":"Hyperthermia is known to induce hypocapnia-driven reductions in cerebral blood flow; however, it is unknown if it causes changes in hemodynamic pulsatility that negatively influence cerebrovascular function. This retrospective analysis aimed to assess cerebrovascular hemodynamic pulsatile buffering (damping factor; DFi) during poikilocapnic (HT) and isocapnic (HT-C) hyperthermia. We hypothesized that HT would reduce cerebral DFi, while HT-C would attenuate the reduction in DFi by limiting increases in resistance. Ten healthy males were passively heated +2°C from normothermia (BL). Blood flow through the internal carotid artery (ICA) and vertebral artery (VA) was measured using vascular ultrasound. Blood velocity through the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) was measured using transcranial ultrasound. DFi was calculated as the ratio of proximal to distal pulsatility index (PI): Anterior cerebral DFi = PIICA/PIMCA; Posterior cerebral DFi = PIVA/PIPCA. Anterior DFi decreased in both HT (1.08 ± 0.19 a.u; p = 0.007) and HT-C (1.12 ± 0.231 a.u; p = 0.021) conditions from BL values (1.27 ± 0.14 a.u). No changes were observed in posterior DFi, p = 0.116. Irrespective of PaCO2 clamping, both hyperthermic conditions reduced anterior DFi, suggesting other mechanisms are responsible for cerebrovascular hemodynamic buffering. Posterior DFi responses were not observed, suggesting preferential buffering of the hyperthermic posterior circulation (VA-PCA).","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70258"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70183

Kaito Tagami, Touko Okuzawa, Keisuke Yoshida, Rin Mishima, Natsuki Obara, Asuko Kunimatsu, Mayako Koide, Tamami Teranishi, Koji Itakura, Katsuhide Ikeda, Toyoaki Murohara, Kohzo Nagata

{"title":"L-arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats.","authors":"Kaito Tagami, Touko Okuzawa, Keisuke Yoshida, Rin Mishima, Natsuki Obara, Asuko Kunimatsu, Mayako Koide, Tamami Teranishi, Koji Itakura, Katsuhide Ikeda, Toyoaki Murohara, Kohzo Nagata","doi":"10.14814/phy2.70183","DOIUrl":"10.14814/phy2.70183","url":null,"abstract":"L-Arginine supplementation has beneficial effects on metabolic disorders in rodents. We here investigated the effects of exogenous L-arginine on cardiac pathology and mitochondrial reactive oxygen species (ROS) production and dynamics in DahlS.Z-Leprfa/Leprfa (DS/obese) rats, a model of metabolic syndrome (MetS). DS/obese rats and their lean homozygous littermate (DahlS.Z-Lepr+/Lepr+, or DS/lean) controls were provided with drinking water containing 0.50% L-arginine-HCl or 0.85% L-alanine (isonitrogenous control) from 13 to 17 weeks of age. L-Arginine supplementation markedly alleviated hypertension without affecting cardiac injury in MetS rats. It also attenuated the increase in ROS production apparent in cardiac mitochondria isolated from MetS rats as well as suppressed the associated upregulation of Nox4 mRNA and protein in the heart. Furthermore, L-arginine reversed the decrease in the size of cardiac mitochondria as well as changes in the expression of DRP1 and OPA1 proteins apparent in the L-alanine-treated MetS rat heart. Cardiac arginase II gene expression and arginase activity were increased by L-arginine treatment in MetS rats but not CONT rats. L-Arginine supplementation thus ameliorated hypertension and cardiac mitochondrial abnormalities in MetS rats, with the lack of a cardioprotective effect possibly being due to increased arginase activity.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70183"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70248

Sarah Witkowski, Tint Tha Ra Wun, JoSophia Brunzelle, Sara Buszkiewicz, Lorna Murphy, Randi L Garcia, Lynnette Leidy Sievert

{"title":"Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.","authors":"Sarah Witkowski, Tint Tha Ra Wun, JoSophia Brunzelle, Sara Buszkiewicz, Lorna Murphy, Randi L Garcia, Lynnette Leidy Sievert","doi":"10.14814/phy2.70248","DOIUrl":"10.14814/phy2.70248","url":null,"abstract":"The menopausal transition is associated with increased risk for cardiovascular disease (CVD). Hot flashes (HF), a cardinal symptom of menopause, have been associated with increased CVD risk, particularly in perimenopausal women. Flow-mediated dilation (FMD) is an indicator of endothelial function and a subclinical CVD risk factor. Lower FMD has been associated with more HF. As moderate to vigorous physical activity (MVPA) is recognized to reduce CVD risk, our goal was to determine whether higher levels of MVPA change the relationship between HF and FMD in perimenopausal women. Healthy perimenopausal women had HF measured objectively using sternal skin conductance for 24 h. MVPA was determined using 7 days of actigraphy. Endothelial function was measured via brachial artery FMD on the non-dominant arm. Pearson correlations and multiple regression analyses were used to evaluate relationships between variables. Simple slopes analysis was performed to understand how MVPA moderates the relationship between HF and FMD. Lower FMD tended to correlate with a higher objective HF rate, and this relationship was stronger for HF measured during waking hours. Controlling for age and BMI, HF and the interaction between HF and MVPA were significant predictors of FMD. Simple slope analysis showed a significant HF effect on FMD with lower (-1SD) MVPA, whereas there was no significant relationship between HF and FMD with higher (+1SD) MVPA. These results suggest that MVPA moderates the relationship between FMD and objective HFs in perimenopausal women.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70248"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myofiber structure, sarcoplasmic reticulum Ca²⁺ handling, and contractile function after muscle-damaging exercise in humans.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70204

V Handegard, P K Lunde, M Frisk, O Seynnes, N Ørtenblad, W E Louch, G Paulsen, T Raastad

{"title":"Myofiber structure, sarcoplasmic reticulum Ca2+ handling, and contractile function after muscle-damaging exercise in humans.","authors":"V Handegard, P K Lunde, M Frisk, O Seynnes, N Ørtenblad, W E Louch, G Paulsen, T Raastad","doi":"10.14814/phy2.70204","DOIUrl":"10.14814/phy2.70204","url":null,"abstract":"Exercise-induced muscle damage (EIMD) is characterized by a severe and prolonged decline in force-generating capacity. However, the precise cellular mechanisms underlying the observed long-lasting decline in force-generating capacity associated with EIMD are still unclear. We investigated in vivo force generation and ex vivo Ca2+-activated force generation, Ca2+ sensitivity, and myofiber Ca2+ handling systems (SR and t-tubules) in human biceps brachii before and 2, 48, and 96 h after eccentrically muscle-damaging contractions and in non-exercised control arm. The force-generating capacity declined by 50 ± 13% 3 h after exercise and was still not recovered after 96 h. The force-Ca relationship of skinned myofibers revealed an impaired maximal Ca2+-activated force in MHC I-fibers, but not MHC II-fibers 48 h after exercise. Further, Ca2+ sensitivity was increased in MHC II-fibers, which was reversed after incubation with a strong reductant. There was a biphasic increase in SERCA sulfonylation, and a parallel reduction in the SR Ca2+ uptake rate, with no effects on SR vesicle leak or SR vesicle Ca2+ release rate. T-tubules showed a progressive increase in the density of longitudinal tubules by 96 h after exercise. In conclusion, MHC II-fiber Ca2+ sensitivity was increased 48 h after exercise, attributed to changes in the REDOX status. 96 h after exercise SR vesicle Ca2+ uptake was impaired, and an increased number of longitudinal tubules were observed. These alterations may contribute to the impaired force generation evident at the late stage of recovery.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70204"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of two different periodized aerobic training on acute cerebrovascular response and cognitive performance in coronary heart disease patients.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70211

Béatrice Bérubé, Maxime Boidin, Mathieu Gayda, Thomas Vincent, Jonathan Tremblay, Martin Juneau, Anil Nigam, Antony D Karelis, Louis Bherer

{"title":"Impact of two different periodized aerobic training on acute cerebrovascular response and cognitive performance in coronary heart disease patients.","authors":"Béatrice Bérubé, Maxime Boidin, Mathieu Gayda, Thomas Vincent, Jonathan Tremblay, Martin Juneau, Anil Nigam, Antony D Karelis, Louis Bherer","doi":"10.14814/phy2.70211","DOIUrl":"10.14814/phy2.70211","url":null,"abstract":"The aim of this study was to measure the effects of chronic and acute aerobic exercise at two different intensities on cognitive performance and cerebrovascular response in coronary heart disease (CHD) patients. Thirty-five CHD patients completed two exercise bouts at 30% and 70% of their respective peak aerobic power on an ergocycle while performing cognitive tasks, which included nonexecutive and executive conditions before and after a 3-month training intervention. Variations of oxy- deoxy- and total hemoglobin concentrations were measured on the left prefrontal cortex at both intensities using near-infrared spectroscopy. Aerobic exercise training consisted of linear and nonlinear periodization protocols for three sessions of 30-50 min per week for 12 weeks. Error rate (p < 0.001) and reaction time (p < 0.001) improved after the training program for the executive condition of the cognitive task, regardless of intensity and training groups. Cerebral oxygenation remained similar pre and post intervention for all conditions and acute exercise intensity. Despite the absence of conjunction between cerebral oxygenation and cognition, results suggest that both exercise training programs could improve cognition in CHD patients during acute exercise.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70211"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of alpha-pinene against paracetamol-induced liver damage in male rats. α-蒎烯对扑热息痛引起的雄性大鼠肝损伤的影响。

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70227

Kaveh Rahimi, Anahita Rezaie, Younes Allahverdi, Parham Shahriari, Mahtab Taheri Mirghaed

{"title":"The effects of alpha-pinene against paracetamol-induced liver damage in male rats.","authors":"Kaveh Rahimi, Anahita Rezaie, Younes Allahverdi, Parham Shahriari, Mahtab Taheri Mirghaed","doi":"10.14814/phy2.70227","DOIUrl":"10.14814/phy2.70227","url":null,"abstract":"This study aims to evaluate the hepatoprotective effect of alpha-pinene against N-acetyl-p-aminophenol, paracetamol, (APA)-induced liver damage in rats. Thirty Wistar rats were divided into five groups (n = 6): Group 1: Normal (control). Group 2: APA 640 mg/kg. Group 3: alpha-pinene 50 mg/kg (APA+ αPi 50 mg/kg). Group 4: alpha-pinene 100 mg/kg (APA+ αPi 100 mg/kg). Group 5: silymarin 50 mg/kg (APA+ SIL). Alpha-pinene or silymarin was orally administered after APA administration for 14 consecutive days. This study investigated liver damage by preparing pathology slides from liver tissue. Levels of AST, ALT, ALP, total bilirubin, total antioxidant capacity (TAC), and total oxidant status (TOS) were measured. Inflammatory factors, including NF-kB gene expression and levels of IL-6 and TNF-a, were also measured. Administering alpha-pinene with APA can prevent liver damage induced by APA. Alpha-pinene can enhance TAC while reducing TOS, ALT, AST, ALP, and total bilirubin. Moreover, the results have also revealed that alpha-pinene decreases NF-kB expression, which leads to a reduction in IL-6 and TNF-a levels. It appears that alpha-pinene induces liver protective effects against APA damage by reducing the activity of liver enzymes, improving antioxidant/oxidative status, and reducing inflammation through the regulation of NF-kB and pro-inflammatory cytokines.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70227"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive pressure ventilation improves oxygen saturation at altitude during recreational aviation: A pilot study.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70210

Jenna L Taylor, Aidan K Downs, Crystal L Danner, J Hunter Downs, Josh Donkor, Jessica I Johnston, Douglas Rozendaal, Peter L Larsen, Bruce D Johnson, Douglas T Summerfield

{"title":"Positive pressure ventilation improves oxygen saturation at altitude during recreational aviation: A pilot study.","authors":"Jenna L Taylor, Aidan K Downs, Crystal L Danner, J Hunter Downs, Josh Donkor, Jessica I Johnston, Douglas Rozendaal, Peter L Larsen, Bruce D Johnson, Douglas T Summerfield","doi":"10.14814/phy2.70210","DOIUrl":"10.14814/phy2.70210","url":null,"abstract":"Aim: We investigated whether a commercial bi-level positive airway pressure (BPAP) device, would improve peripheral oxygen saturation (SpO2) during recreational aviation up to 12,500 feet without supplemental oxygen. Ten adults with recreational flight experience (age:47 ± 14; female = 5) completed a standardized flight profile in an unpressurised aircraft, involving randomized crossover design at 8,000 feet and 12,500 feet with BPAP or control. SpO2, middle cerebral artery velocity (MCAv), heart rate (HR), respiratory rate (RR), and relative tidal volume (TV) index were measured continuously. Psychomotor vigilance test (3-min) assessed reaction time halfway through taxi and altitude stages. Altitude significantly (p < 0.05) decreased mean SpO2, MCAv, and RR, and increased TV index and HR. There was no effect of altitude (p > 0.05) on reaction time. BPAP increased mean SpO2 at 8,000 feet [Control: 92 ± 1%; BPAP: 94 ± 2%; mean difference (MD) = 2 ± 2%; p = 0.002] and 12,500 feet [Control: 86 ± 4%; BPAP: 89 ± 4%; MD = 2 ± 3%; p = 0.013]. BPAP lowered MCAv at 8,000 feet [Control: 53 ± 10 cm/s; BPAP: 50 ± 9 cm/s; MD = -3 ± 2 cm/s; p = 0.001] and 12,500 feet [Control: 52 ± 10 cm/s; BPAP: 50 ± 8 cm/s; MD = -2 ± 3 cm/s; p = 0.041]. BPAP increased TV index at 8,000 feet (Control: 6.6 ± 1.3; BPAP:8.1 ± 1.8; MD = 1.9 ± 0.8; p < 0.001) but not 12,500 feet, without effect on RR or reaction time. This study provides preliminary results that BPAP may improve mean SpO2 for recreational aviators up to 12,500 feet without supplemental oxygen.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70210"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70219

Emily Dow, Mario I Hernandez, Carol S Johnston

{"title":"Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial.","authors":"Emily Dow, Mario I Hernandez, Carol S Johnston","doi":"10.14814/phy2.70219","DOIUrl":"10.14814/phy2.70219","url":null,"abstract":"To explore a potential link between resistance exercise and the gut-brain axis, this study examined the impact of resistance exercise on intestinal permeability, as indicated by lipopolysaccharide binding protein (LBP), and mood state in healthy adults. Sedentary participants (n = 20; 39.5 ± 12.1 y; 27.4 ± 5.3 kg/m2) were randomly assigned to the resistance exercise (REX) or wait-listed control (CON) groups. REX participants strength trained 3× weekly (advancing from 45%-55% to 70%-80% 1RM for 3-4 sets over 8 weeks). Strength testing, evaluation of mood states, and collection of fasting blood occurred at baseline and weeks 4 and 8. At baseline, LBP concentrations were inversely correlated to all strength measures (r range: -0.48 to -0.57; p < 0.05). The gain in total strength [(split squat left + right)/2 + bench press] was 45% higher for REX versus CON participants (p = 0.019), and serum LBP concentrations fell 16% for REX participants and rose 9% in CON participants (p = 0.014). Mood was significantly improved by resistance training versus control (but this improvement was not related to changes in LBP; r = -0.001). These findings support a role for resistance exercise in improving mood state and intestinal barrier function, but more research is warranted to further explore the effects of resistance training on the gut-brain axis.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70219"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70215

Gabriel Stölting, Nicole Hellmig, Hoang An Dinh, Frederike Butz, Ali Kerim Secener, Marina Volkert, Ute I Scholl

{"title":"Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa.","authors":"Gabriel Stölting, Nicole Hellmig, Hoang An Dinh, Frederike Butz, Ali Kerim Secener, Marina Volkert, Ute I Scholl","doi":"10.14814/phy2.70215","DOIUrl":"10.14814/phy2.70215","url":null,"abstract":"The zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis. Aldosterone synthesis is primarily regulated via tightly controlled oscillations in intracellular calcium levels in response to stimulation. It has previously been shown that calcium oscillations are synchronized through mechanical linkage between adjacent ZG cells. In many other cell types, similar synchronization is rather dependent on gap junctions (GJ). The recent discovery of mutations in CADM1 was linked to impaired GJ function in the ZG. Based on published transcriptomics data, we re-examined the presence and functional impact of GJ in the ZG. We found evidence for the expression of murine connexin 43 and 37 using microarray data, in-situ hybridization and immunohistology. Connexin 43 was also present in human samples. Calcium oscillations in ZG rosettes showed some degree of synchronization as reported previously. Unspecific GJ inhibition only had a small impact on this synchronicity. However, no signs of connections between cytosols could be observed as indicated by the lack of fluorescence recovery after photobleaching. We conclude that, while connexin proteins are expressed in the ZG, functional GJ in the physiological ZG are rare and of little consequence for calcium signaling.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70215"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0