Physiological Reports最新文献_第9页

An exploratory, in-field, multimodal assessment of cervical function in adults following to high-altitude trekking with light backpack. 一项探索性的、实地的、多模式的评估成人在高海拔徒步旅行后的颈椎功能。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71060

David Perpetuini, Vittore Verratti, Danilo Bondi, Arcangelo Merla, Egidio Botta, Michele D'Attilio

{"title":"An exploratory, in-field, multimodal assessment of cervical function in adults following to high-altitude trekking with light backpack.","authors":"David Perpetuini, Vittore Verratti, Danilo Bondi, Arcangelo Merla, Egidio Botta, Michele D'Attilio","doi":"10.14814/phy2.71060","DOIUrl":"https://doi.org/10.14814/phy2.71060","url":null,"abstract":"Hours-lasting walks with backpacks can trigger or worsen musculoskeletal dysfunctions of the neck, and high-altitude hypoxia adds to the stress. To delve deeper into this topic, this study analyzed the functional and neuromuscular alterations at the head-and-neck region during high-altitude trekking by combining thermal imaging, electromyography, and kinematics. Fifteen adults who took part in a Himalayan expedition were tested for cervical range of motion (RoM) at 1400 m, at peak altitude staying (5000 meters), and once back at 1400 m, during a trek lasting 14 days. The 8 males were also tested for surface electromyography (sEMG) and infrared thermography. The maximum RoM of flexion-extension along the sagittal plane increased in response to trekking. Surface electromyography revealed greater activation at the end of the trek in right side for rotation and the left side for bending. Thermography revealed a general reduction of skin temperature over the target muscles during side bending. This study highlights the feasibility and usefulness of multimodal analysis through inertial measurement unit-registered kinematics, thermography, and electromyography in monitoring neck function in a demanding real-world environment. The high-altitude trek, with a backpack weighing less than 10% of one's body weight, triggers asymmetrical adaptations in the neck muscles, increasing measured RoM.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71060"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13487380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of breathing route on pulmonary and sensory responses to ozone exposure during exercise in adults. 呼吸方式对运动中臭氧暴露对肺和感觉反应的影响。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71071

André C Silveira, Aidan K Comeau, Matthew G Skirrow, Jonah Brindley, Simon Boulianne, Christopher Hansen-Barkun, Jem I Arnold, Romulo Bertuzzi, Michael S Koehle

{"title":"The impact of breathing route on pulmonary and sensory responses to ozone exposure during exercise in adults.","authors":"André C Silveira, Aidan K Comeau, Matthew G Skirrow, Jonah Brindley, Simon Boulianne, Christopher Hansen-Barkun, Jem I Arnold, Romulo Bertuzzi, Michael S Koehle","doi":"10.14814/phy2.71071","DOIUrl":"10.14814/phy2.71071","url":null,"abstract":"Ozone (O3) is a photochemical air pollutant known to reduce lung function and induce respiratory symptoms. This study aimed to determine whether breathing route influences O3-induced lung function changes during exercise. Thirteen recreationally active participants (6 females, V̇O2peak = 45.8 ± 5.3 mL/kg/min), with no history of cardiovascular or pulmonary disease or exercise-induced bronchoconstriction, completed a double-blind crossover study with four experimental visits. Participants performed 30 min of low-intensity cycling (90% of power at the first ventilatory threshold) while breathing exclusively nasally or orally under room air or 0.40 ppm O3. Spirometry was assessed before and after each trial, and dyspnea (Multidimensional Dyspnea Profile) every 5 min during exercise. O3 exposure impaired pulmonary function, reducing FEV1, FVC, PEF, FEF25-75, and FEV1/FVC (all p < 0.05). Regardless of environmental condition, oral breathing produced modestly greater post-exercise reductions in FEV1, PEF, FEF25-75, and FEV1/FVC than nasal breathing, but no breathing route × environment interaction was observed. Nasal breathing was associated with greater breathing effort and air hunger (p < 0.05). Thus, O3 exposure impaired pulmonary function and increased dyspnea regardless of breathing route. Although nasal breathing slightly attenuated overall post-exercise lung function decline, it did not protect against O3-induced pulmonary impairment and increased breathing discomfort during exercise.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71071"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a glucosinolate-rich beverage on blood lactate concentrations during submaximal exercise. 富含硫代葡萄糖苷的饮料对亚极限运动时血乳酸浓度的影响。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71081

Fredrik Vinge, Emma Tillqvist, Oscar Horwath, William Apró, Filip J Larsen, Michaela L Sundqvist

{"title":"Effects of a glucosinolate-rich beverage on blood lactate concentrations during submaximal exercise.","authors":"Fredrik Vinge, Emma Tillqvist, Oscar Horwath, William Apró, Filip J Larsen, Michaela L Sundqvist","doi":"10.14814/phy2.71081","DOIUrl":"10.14814/phy2.71081","url":null,"abstract":"Glucosinolate-rich red kale sprouts (GRS) combined with intense exercise training for 7 days reduce blood lactate during exercise, attenuate hypoglycemic events, improve performance, and reduce markers of oxidative stress. This study aimed to investigate the acute, dose-dependent effects of GRS on blood lactate and blood glucose after ingestion of two different doses. In the study, healthy participants (n = 15) consumed 37.5 or 75 g of GRS or an isocaloric placebo blended into a beverage on three occasions. They cycled on an ergometer at three submaximal work rates (~100, ~120, ~140 W, respectively) before and 3 h after ingestion of GRS. Oxygen uptake, substrate-level oxidation, blood lactate, blood glucose, and ratings of perceived exertion were taken before and after each interval. GRS intake acutely decreased blood lactate during submaximal cycling and increased resting blood glucose. The largest lactate reduction occurred at 37.5 g compared to placebo, with concentrations 0.4 ± 0.6 mM lower at the highest work rate (p = 0.00175). For 75 g, the reduction was 0.3 ± 0.5 mM (p = 0.0484). No significant effects appeared at the lowest work rate. Resting blood glucose averaged 3.9 ± 0.3 mM after placebo compared to 4.3 ± 0.4 mM after 37.5 g and 4.3 ± 0.4 mM after 75 g GRS (p < 0.0001, respectively). In conclusion, these findings suggest that acute intake of a glucosinolate-rich beverage may influence lactate and glucose metabolism, with lower blood lactate concentrations observed at two submaximal work rates and altered blood glucose concentrations at rest.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71081"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot randomized controlled trial of the effects of dietary nitrate supplementation on dynamic cerebral autoregulation in older adults with metabolic syndrome. 膳食硝酸盐补充对老年代谢综合征患者动态脑自动调节影响的随机对照试验。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71073

Jigar Gosalia, Jocelyn M Spicuzza, Christine Bowlus, Annabelle Brinkerhoff, Stephen R Baker, Juan Jan Qiu, Daniel B Kim-Shapiro, Jim A Pawelczyk, David N Proctor

{"title":"A pilot randomized controlled trial of the effects of dietary nitrate supplementation on dynamic cerebral autoregulation in older adults with metabolic syndrome.","authors":"Jigar Gosalia, Jocelyn M Spicuzza, Christine Bowlus, Annabelle Brinkerhoff, Stephen R Baker, Juan Jan Qiu, Daniel B Kim-Shapiro, Jim A Pawelczyk, David N Proctor","doi":"10.14814/phy2.71073","DOIUrl":"10.14814/phy2.71073","url":null,"abstract":"Metabolic syndrome (MetS) is associated with reduced nitric oxide (NO) bioavailability and impaired cerebrovascular function, potentially increasing cognitive decline risk. Dynamic cerebral autoregulation (dCA) maintains cerebral blood flow and may involve NO-related vascular mechanisms. Whether dietary nitrate supplementation influences dCA in MetS remains unclear. This pilot trial evaluated feasibility and explored effects of nitrate supplementation on dCA. Twenty-two older adults with MetS (55-75 years) were randomized in a double-blind, placebo-controlled design to receive nitrate-rich beetroot juice (BRJ; 6.4 mmol NO3 -·day-1) or nitrate-depleted placebo for 4 week. dCA was assessed using transfer function analysis (TFA) of beat-to-beat blood pressure and functional near-infrared spectroscopy-derived cerebral oxygenation. Primary analyses examined frontal dCA holistically, with exploratory regional and cognitive outcomes. dCA was indexed by TFA phase and gain. The intervention was well tolerated, adherence was high, and BRJ increased plasma nitrate concentrations versus placebo (p < 0.001). No significant effects were observed for frontal dCA or cognition. Exploratory analyses indicated region-specific differences in dCA in select frontal areas, characterized by improvements in TFA phase and gain. This pilot trial demonstrates the feasibility of dietary nitrate supplementation in MetS. While no effects were observed in primary outcomes, exploratory analyses suggest potential region-specific improvements in dCA.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71073"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cavβ4 subunit of Cav1.2 channels antagonizes isoproterenol-induced hypertrophy in rat cardiac muscle cells by down-regulating miR-183-5p. Cav1.2通道的Cavβ4亚基通过下调miR-183-5p拮抗异丙肾上腺素诱导的大鼠心肌细胞肥厚。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71037

Elba D Carrillo, Erick Galicia, María C García, Jorge A Sánchez

{"title":"The Cavβ4 subunit of Cav1.2 channels antagonizes isoproterenol-induced hypertrophy in rat cardiac muscle cells by down-regulating miR-183-5p.","authors":"Elba D Carrillo, Erick Galicia, María C García, Jorge A Sánchez","doi":"10.14814/phy2.71037","DOIUrl":"10.14814/phy2.71037","url":null,"abstract":"The Cavβ4 subunit of voltage-gated Cav1.2 channels regulates gene expression in neurons and cardiac cells. It increases the expression of interferon-β-related genes in H9c2 cardiomyocytes derived from rat ventricular tissue, but the possibility that it also regulates the expression of microRNAs (miRs) remains unexplored. Furthermore, its role in cardiac hypertrophy is unknown. Although the mechanisms underlying cardiac hypertrophy have been studied extensively, the antihypertrophic response is poorly understood. We conducted quantitative reverse-transcriptase polymerase chain reaction, western blot, and immunofluorescence experiments with H9c2 cardiomyocytes to examine the effects of Cavβ4 overexpression on isoproterenol-induced hypertrophy; the protein abundance of the transcription factors nuclear receptor 4A2 (NR4A2) and forkhead box O1 (FOXO1), which counter agonist-induced hypertrophic growth; and the expression of miR-183-5p, which targets NR4A2 and FOXO1 mRNAs. We found that the Cavβ4 subunit prevented the development of H9c2 cardiomyocyte hypertrophy, down-regulating miR-183-5p expression and increasing the protein abundance of NR4A2 and FOXO1. We also observed a transient decrease in Cavβ4 mRNA expression in rat ventricles at 6 h after isoproterenol injection. These results suggest that the Cavβ4 subunit plays a channel-independent role in the antihypertrophic response in cardiac muscle cells.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 15","pages":"e71037"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13415754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological mechanisms and therapeutic targets in chronic cough. 慢性咳嗽的生理机制及治疗靶点。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71036

James C Brown, Katherine L Rhatigan, Oliver J Price, Peter S P Cho

{"title":"Physiological mechanisms and therapeutic targets in chronic cough.","authors":"James C Brown, Katherine L Rhatigan, Oliver J Price, Peter S P Cho","doi":"10.14814/phy2.71036","DOIUrl":"10.14814/phy2.71036","url":null,"abstract":"Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited. Cough reflex hypersensitivity is conventionally considered to underpin the pathophysiology of chronic cough, primarily mediated by peripheral nerve dysfunction. Whilst this framework has led to important mechanistic insights and effective pharmacotherapies, recent functional neuroimaging studies have demonstrated equally important central mechanisms. Taken together, cough reflex hypersensitivity may not be mediated exclusively by peripheral nerve dysfunction, and the answer may lie within a complex interplay of central and peripheral neural physiology. In the pathophysiology of chronic cough, impaired voluntary suppression also appears to be important. This review will provide an overview of the physiology and pathophysiology of chronic cough and attempts in pharmacotherapy to date.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 15","pages":"e71036"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-casein in human milk is associated with infant stool frequency: A pilot proteomics study. 人乳中的β -酪蛋白与婴儿大便频率有关：一项初步蛋白质组学研究。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71027

Zhan-Hua Li, Zhen-Rong Xie, Meng Li, Jing-Jing Xiong, Mei Liu, Yong-Kun Huang

{"title":"Beta-casein in human milk is associated with infant stool frequency: A pilot proteomics study.","authors":"Zhan-Hua Li, Zhen-Rong Xie, Meng Li, Jing-Jing Xiong, Mei Liu, Yong-Kun Huang","doi":"10.14814/phy2.71027","DOIUrl":"10.14814/phy2.71027","url":null,"abstract":"Breast milk proteins may regulate gut function and defecation frequency; however, their specific roles in these processes remain poorly understood. We hypothesized that variations in specific human milk proteins are associated with differences in stool frequency among exclusively breastfed infants. Infants were categorized into three groups based on defecation frequency: Group A (normal, 1-3 times per day), Group B (frequent, >3 times per day), and Group C (infrequent, ≤1 time every 3-4 days). Each group consisted of three biological replicates (total N = 9). This study was an exploratory pilot study. Breast-milk samples were analyzed using tandem mass tag (TMT)-based proteomics to identify differentially expressed proteins across groups. Gene Ontology (GO), KEGG pathway enrichment, and protein-protein interaction (PPI) analyses were conducted to explore functional pathways. A total of 2563 proteins were identified; β-casein, αs1-casein, and κ-casein were significantly downregulated in infants with lower defecation frequency (Group C vs. Group A; fold change <0.6, p < 0.05). β-casein showed the most significant difference (p = 0.0003). Enrichment analysis revealed pathways related to glycolipid metabolism, fibroblast proliferation, and coagulation cascades, while PPI analysis identified fibrinogen-related proteins as key interaction nodes. These findings suggest that β-casein levels in breast milk are associated with infant stool frequency. This may help clarify the association between constipation, diarrhea, and breastfeeding in infants and young children and may provide a theoretical reference for the subsequent development of targeted breast milk fortifiers and improvements in the intestinal environment in infants.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 15","pages":"e71027"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial sarcomere adaptation to eccentric overload training is blunted in ovariectomized rats. 去卵巢大鼠连续肌节对偏心负荷训练的适应性减弱。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71070

Amelia Rilling, Alexandra Q Kirkup, Avery Hinks, Martino V Franchi, Geoffrey A Power

{"title":"Serial sarcomere adaptation to eccentric overload training is blunted in ovariectomized rats.","authors":"Amelia Rilling, Alexandra Q Kirkup, Avery Hinks, Martino V Franchi, Geoffrey A Power","doi":"10.14814/phy2.71070","DOIUrl":"10.14814/phy2.71070","url":null,"abstract":"Eccentric contractions performed to long muscle lengths impose high mechanical stress and strain on the muscle fiber, providing a stimulus for longitudinal growth (i.e., increases in serial sarcomeres number (SSN)). Conventional (CONV) resistance training incorporates eccentric and concentric phases; however, mechanical loading is constrained by the concentric phase. Eccentric overload (ECCOVERLOAD) training has a maximal load throughout the eccentric phase increasing the potential for greater sarcomerogenesis. The purpose was to investigate ECCOVERLOAD and CONV training on mechanical and morphological adaptation in ovary-intact and OVX rats. Intact and OVX Sprague-Dawley rats performed 4 weeks (×3/week) of ECCOVERLOAD or CONV resistance training. Mechanical measures were tested pre- and post-training. Fascicle length and sarcomere length were measured to obtain SSN. Torque increased (p < 0.001) similarly across groups at the shorter muscle (p = 0.075) and greater at the longer muscle lengths (p = 0.002) in OVX rats. In the soleus, there was a training× hormone status× training group (p = 0.028) interaction, such that intact rats showed the greatest improvement in SSN with ECCOVERLOAD (~13%), which was higher than both CONV intact (~3%) and OVX rats in either training condition (ECCOVERLOAD ~1%, CONV ~5%). Therefore, OVX had a blunted adaptation in longitudinal muscle remodeling in response to ECCOVERLOAD training.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71070"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of short-term hand immobilization on motor functions across domains in adults. 短期手部固定对成人各脑区运动功能的影响。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71068

Lasse Jespersen, August Lomholt Kvistad, Jonas Rud Bjørndal, Jesper Lundbye-Jensen

{"title":"Effects of short-term hand immobilization on motor functions across domains in adults.","authors":"Lasse Jespersen, August Lomholt Kvistad, Jonas Rud Bjørndal, Jesper Lundbye-Jensen","doi":"10.14814/phy2.71068","DOIUrl":"10.14814/phy2.71068","url":null,"abstract":"Short-term limb immobilization is known to impair muscle strength; however, its effects across distinct domains of motor function remain incompletely characterized. In this study, we assessed the effects of 72-h of hand immobilization on motor functions in healthy adults. Twenty-eight participants were randomized to an immobilization or control group and completed a motor test battery before and after the intervention. The battery assessed maximal and explosive strength, quantified as maximal voluntary contraction (MVC) force and rate of force development (RFD), fatigability during sustained maximal contractions, force steadiness during submaximal contractions, and manual dexterity. Immobilization induced domain-specific impairments in motor performance. MVC force and RFD declined significantly following immobilization, indicating susceptibility of maximal and explosive strength to short-term disuse. In contrast, no significant changes were observed in the selected parameters of fatigability during sustained maximal contractions, including the fatigue time constant and plateau force. Force steadiness showed a selective increase in relative force variability, whereas absolute force variability remained unchanged. Manual dexterity was not reduced from baseline, but immobilization attenuated the test-retest performance improvements observed in the control group and contralateral non-immobilized hand. These findings demonstrate that hand immobilization induces task- and domain-specific alterations in motor performance rather than a uniform decline, preferentially affecting motor domains that require high force production.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71068"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case study: Body composition and bone changes following a thru-hike of the Pacific Crest Trail by a young female adult. 案例研究：一个年轻的成年女性在穿越太平洋屋脊步道后的身体组成和骨骼变化。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71058

Dale R Wagner, Edward M Heath, Macy Gustavus

引用次数: 0