Physiological Reports最新文献_第8页

Although myeloid-cell RGS2 knockout does not affect Ang II-induced hypertension/organ damage in mice, high RGS2 in Gitelman/Bartter syndromes-human models of endogenous Ang II signaling antagonism-is associated with hypotensive/antiremodeling effects. 尽管髓细胞RGS2敲除不会影响angii诱导的小鼠高血压/器官损伤，但在Gitelman/Bartter综合征（内源性angii信号拮抗的人类模型）中，高RGS2与降压/抗重塑作用有关。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71110

Lorenzo A Calò, Martina Cacciapuoti, Paul A Davis

引用次数: 0

Prospective echocardiographic characterization of postnatal cardiac development in C57BL/6 mice: Strain analysis between birth and adulthood. C57BL/6小鼠出生后心脏发育的前瞻性超声心动图特征：出生和成年之间的品系分析。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71113

Sehjin Jo, George Spyropoulos, Logan G Hart, Taylor A Covington, Arvind K Pandey, Thomas Michel, Fotios Spyropoulos

{"title":"Prospective echocardiographic characterization of postnatal cardiac development in C57BL/6 mice: Strain analysis between birth and adulthood.","authors":"Sehjin Jo, George Spyropoulos, Logan G Hart, Taylor A Covington, Arvind K Pandey, Thomas Michel, Fotios Spyropoulos","doi":"10.14814/phy2.71113","DOIUrl":"10.14814/phy2.71113","url":null,"abstract":"Echocardiography is critical for characterizing murine models of cardiovascular disease, yet normative data for the early postnatal period, particularly advanced functional metrics like myocardial strain, remain undefined. This developmental window features rapid cardiac maturation and is central to modeling congenital and neonatal heart disease. To establish normative, sex-specific trajectories of cardiac structure and function between birth and adulthood, we performed prospective high-frequency echocardiography in C57BL/6 mice at postnatal day 0 (P0), P8, P21, and week 8 (Wk8). Somatic growth and left ventricular structural dimensions increased progressively from P0 to Wk8. This structural maturation was accompanied by lower ejection fraction and fractional shortening, attributable to geometric remodeling. In contrast, speckle-tracking strain analysis revealed that intrinsic myocardial deformation, including global circumferential and radial strain, remained stable throughout postnatal development. Importantly, we identified sexual dimorphism emerging during late adolescence; by Wk8, males exhibited significantly greater longitudinal and radial strain magnitudes than females. This study provides the first prospective, myocardial strain-based echocardiographic characterization of murine cardiac development between birth and adulthood, identifying P21-Wk8 as a critical window for sex-specific cardiac mechanics. These normative trajectories provide a translational framework for interpreting cardiac phenotypes in preclinical models of congenital, pediatric, and developmental cardiovascular disease.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 18","pages":"e71113"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal temperature of elite and recreational adult runners during a 100-mile ultramarathon under heat exposure. 精英和休闲成年跑步者在热暴露下100英里超级马拉松期间的胃肠温度。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71089

Loïs Mougin, Richard Stennett, Brett R Ely, Baptiste Morel, Larry O'Neill, Chris Esh, William M Adams, Daniel P Longman, Richard C Blagrove, Lee Taylor, Stephen A Mears

{"title":"Gastrointestinal temperature of elite and recreational adult runners during a 100-mile ultramarathon under heat exposure.","authors":"Loïs Mougin, Richard Stennett, Brett R Ely, Baptiste Morel, Larry O'Neill, Chris Esh, William M Adams, Daniel P Longman, Richard C Blagrove, Lee Taylor, Stephen A Mears","doi":"10.14814/phy2.71089","DOIUrl":"10.14814/phy2.71089","url":null,"abstract":"This study examined gastrointestinal temperature (TGI) during and body mass (BM) changes pre/post the Western States Endurance Run 100 (WSER), a 100-mile ultramarathon in hot conditions. Thirty-nine participants ingested a telemetric pill 30-90 min before the WSER start, and BM was measured pre- and post-race. Environmental conditions were recorded every 30 min at 15 locations along the course. In-race TGI data were obtained from 23 finishers (54%; 7 females; 42 ± 11 years), including 2 podium finishers and an additional top-10 finisher. Participants finished in 14-18 h (n = 4), 19-25 h (n = 6), and 26-30 h (n = 13). Peak TGI averaged 38.90°C ± 0.55°C (range 37.76°C-40.09°C) with 9 runners exceeding 39°C and 2 exceeding 40°C. Faster finish times were associated with higher peak TGI (r = -0.57, p = 0.004). Seven runners (30%) reached peak TGI in the final 2% of the race. Mean BM change was -1.8% ± 3.1% (range -7.4% to +6.4%), with no associations observed between BM change and peak TGI or finish time. Ambient temperature ranged 5°C-39.6°C and was associated with higher TGI (r = 0.80, p = 0.008). Despite ambient temperatures approaching 40°C, TGI >40°C were rare and transient. Faster runners experienced greater thermal strain, likely reflecting higher metabolic heat production and exposure to the hottest course segments. Hyperthermia risk may be highest near the race finish and during the most demanding segments.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 17","pages":"e71089"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young adults. 青年成人急性联合传统或高强度战术训练后血清代谢组学特征。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71094

Zachary A Graham, Khyatiben V Pathak, Krystine Garcia-Mansfield, Kaleen M Lavin, Anakaren R Torres, Jeremy S McAdam, Timothy Broderick, Patrick Pirrotte, Marcas M Bamman

{"title":"Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young adults.","authors":"Zachary A Graham, Khyatiben V Pathak, Krystine Garcia-Mansfield, Kaleen M Lavin, Anakaren R Torres, Jeremy S McAdam, Timothy Broderick, Patrick Pirrotte, Marcas M Bamman","doi":"10.14814/phy2.71094","DOIUrl":"10.14814/phy2.71094","url":null,"abstract":"Alternative exercise prescriptions and doses would be expected to result in distinct signatures due to differences in duration and intensity. We tested two novel combined endurance and resistance exercise regimens to understand how differing prescriptions alter the timecourse of metabolomics response. Serum metabolomics for n = 37 untrained individuals was completed following traditional combined exercise [TRAD; n = 20 (11M/9F)] or high-intensity tactical training [HITT; n = 17 (8M/9F)] before (pre), and immediately (h0), 3 and 24 h post-exercise (h3 and h24, respectively). We found minimal metabolites had a group by time interaction (4 with FDR-adjusted q values <0.10; 9 with nominal p < 0.01), but both stimuli resulted in large-scale within-group changes to the circulating metabolome. TRAD had greater numbers of differentially abundant metabolites (FDR <0.10) compared to HITT at h0 (451 vs. 358), h3 (446 vs. 348) and h24 (183 vs. 86). The metabolite classes altered were related to key energy substrates for both groups at h0 and energy replenishment for h3 and h24. In summary, our data describe the acute changes in the circulating metabolome following combined endurance and resistance exercise. Additionally, we show the two distinct doses of combined exercise led to generally similar patterns of responses.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 18","pages":"e71094"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological changes in the arterial pressure waveform following hemodynamic therapies in critical care: A clinical proof-of-concept study in older adults. 危重监护血流动力学治疗后动脉压波形的形态学改变：老年人临床概念验证研究

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71032

F M de Raat, M P Mulder, A J R De Bie Dekker, A R Bouwman, L J Montenij, D W Donker

{"title":"Morphological changes in the arterial pressure waveform following hemodynamic therapies in critical care: A clinical proof-of-concept study in older adults.","authors":"F M de Raat, M P Mulder, A J R De Bie Dekker, A R Bouwman, L J Montenij, D W Donker","doi":"10.14814/phy2.71032","DOIUrl":"10.14814/phy2.71032","url":null,"abstract":"Clinical management of hemodynamic instability remains challenging as underlying mechanisms are complex. A recent in-silico study showed that peripheral arterial waveform analysis can differentiate deficits in preload, afterload, and contractility. This study explores the clinical applicability of these findings. In this prospective observational study, continuous peripheral arterial blood pressure recordings were obtained from patients during and after cardiac surgery. Retrospectively, we identified isolated therapeutic events with expected physiological effects on preload (fluid bolus), afterload (norepinephrine), or contractility (dobutamine). Waveform morphology was characterized by 23 features. 132 patients were included; 92 fluid boluses, 91 norepinephrine, and 35 dobutamine administrations. Four waveform features differed significantly between the three types of events: augmented pressure (systolic peak minus anacrotic notch, p = 0.001), diastolic/systolic area ratio (p < 0.001), relative systolic downstroke time (p = 0.002), and relative diastolic time (p = 0.004). Fluid boluses increased the systolic component, norepinephrine increased the diastolic component, and dobutamine decreased augmented pressure by -3.0 (95% CI -4.5 to -1.6) mmHg (p < 0.001). Distinct morphological alterations of the peripheral arterial waveform were observed following a fluid bolus, norepinephrine, and dobutamine, providing a basis for future studies.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 15","pages":"e71032"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13415750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirst and blood pressure regulation in a novel angiotensin II receptor type 1a knockout rat. 新型血管紧张素II受体1a型敲除大鼠的口渴和血压调节。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71042

Caroline B Ferreira, Sean D Stocker

{"title":"Thirst and blood pressure regulation in a novel angiotensin II receptor type 1a knockout rat.","authors":"Caroline B Ferreira, Sean D Stocker","doi":"10.14814/phy2.71042","DOIUrl":"10.14814/phy2.71042","url":null,"abstract":"Angiotensin II (AngII) plays a pivotal role in body fluid balance through AngII type 1 receptors (Agtr1) expressed in circumventricular organs to stimulate thirst. Blockade of central Agtr1 attenuates thirst to hypotension but not acute hypernatremia. Data in genetic knockout models are limited as systemic AngII does not stimulate thirst in mice, and Agtr1a-/- mice are severely hypotensive. Therefore, we generated a novel Agtr1a-/- rat using CRISPR-Cas9 to produce an 11-bp frame-shift deletion in exon 3. Baseline mean arterial blood pressure (ABP) was approximately 10 mmHg lower in Agtr1a-/- vs. wild-type (WT) rats with no differences in heart rate. Depressor responses to ganglionic blockade, vasopressin receptor blockade, or angiotensin converting enzyme inhibition were not different between strains. Systemic AngII (40 ng/min, IV) significantly increased water intake and mean ABP in WT rats, but these responses were absent in Agtr1a-/- rats. Hypotension-induced thirst produced by the vasodilator diazoxide (25 mg/kg, IV) stimulated water intake in WT but not in Agtr1a-/- rats. In contrast, water intake stimulated by hypernatremia (2 M NaCl, IV) or overnight water deprivation was not different between strains. These findings support a critical role for Agtr1a in thirst induced by AngII and hypotension but not by hypernatremia or overnight water deprivation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 15","pages":"e71042"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratracheal interleukin-10 administration reduces acute lung injury induced by sulfur dioxide exposure in mice. 气管内给予白细胞介素-10可减少二氧化硫暴露引起的小鼠急性肺损伤。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71079

Amy J Nelson, Todd A Wyatt, Bradley W Richmond, Belinda Diaz, Angela M Gleason, Michael J Duryee, Geoffrey M Thiele, Ted R Mikuls, Jill A Poole

{"title":"Intratracheal interleukin-10 administration reduces acute lung injury induced by sulfur dioxide exposure in mice.","authors":"Amy J Nelson, Todd A Wyatt, Bradley W Richmond, Belinda Diaz, Angela M Gleason, Michael J Duryee, Geoffrey M Thiele, Ted R Mikuls, Jill A Poole","doi":"10.14814/phy2.71079","DOIUrl":"10.14814/phy2.71079","url":null,"abstract":"Therapies capable of reducing acute high-consequence airborne chemical exposure-induced lung disease are lacking. This study seeks to determine the therapeutic potential of interleukin (IL)-10 administered following acute sulfur dioxide (SO2) exposure in mice. C57BL/6 male and female mice were exposed to SO2 gas at 125 ppm for 4 h and subsequently treated 2-3 h later with IL-10 (1 μg) or vehicle control by intratracheal instillation for a total of 3 doses over 2 days with comparisons to sham-treated mice (N = 20 mice/group). IL-10 treatment reduced SO2-induced weight loss with corresponding reductions in SO2-induced circulating markers of inflammation (pentraxin-2 and fibrinogen). IL-10 reduced SO2-induced markers of lung cell permeability (surfactant protein-D and protein), and cell death (lactate dehydrogenase [LDH]). SO2-induced lung infiltrates of neutrophils and activated macrophages were reduced with IL-10 treatment. IL-10 reduced SO2-induced increases in total protein, Substance P, apoptotic cells, post-translational citrullinated and malondialdehyde-acetaldehyde-modified proteins, and vimentin. Compared to female mice, SO2 exposure led to greater increases in serum pentraxin-2, fibrinogen, LDH levels, and lavage fluid cells in males. In conclusion, short-term, intratracheal IL-10 therapy administered after acute SO2 exposure favorably modulates acute lung injury consequences to suggest a therapeutic potential to decrease adverse systemic and lung effects.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71079"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent exogenous ketosis increases erythropoietin in healthy adults: A randomized, placebo-controlled study with preliminary sex-specific observations. 间歇性外源性酮症增加健康成人的促红细胞生成素：一项随机、安慰剂对照研究，初步性别特异性观察。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71041

Henrik Holm Thomsen, Birgitte Sandfeld-Paulsen, Lise Nørkjær Bjerg, Jesper Nørgaard Bech

{"title":"Intermittent exogenous ketosis increases erythropoietin in healthy adults: A randomized, placebo-controlled study with preliminary sex-specific observations.","authors":"Henrik Holm Thomsen, Birgitte Sandfeld-Paulsen, Lise Nørkjær Bjerg, Jesper Nørgaard Bech","doi":"10.14814/phy2.71041","DOIUrl":"10.14814/phy2.71041","url":null,"abstract":"Exogenous ketosis may stimulate erythropoietin (EPO), yet its impact on erythropoiesis, iron metabolism, and potential sex-specific responses in humans remains unknown. We investigated these effects in healthy adults using oral β-hydroxybutyrate ketone monoester (KE) to induce intermittent ketosis. Acute EPO responses to a single dose of KE were assessed in 16 healthy adults (pre-post), followed by a 2-week randomized study (KE twice daily vs. placebo). After 2 weeks, EPO levels with intermittent ketosis were approximately 30% higher (95% CI 6, 60), p = 0.01, an effect more evident in females (9.7 IU/L (95% CI 6.0, 13.5) vs. 6.4 IU/L (95% CI 4.0, 8.8), p = 0.008) than in males (10.7 IU/L (7.2, 14.2) vs. 9.6 IU/L (6.3, 12.9), p = 0.46). Ferritin was elevated in females with KE vs. placebo (42 μg/L vs. 16 μg/L, p < 0.001). Hemoglobin and red blood cell count were unaffected at 2 weeks. Over 2 weeks, intermittent exogenous ketosis was associated with a modest increase in erythropoietin levels, with a stronger signal in females. Although hemoglobin and red blood cell count did not change significantly, females showed higher ferritin levels and a trend toward increased hematocrit, suggesting subtle effects on erythropoietic stimulation and iron handling.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 15","pages":"e71041"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagic responses to vigorous endurance exercise in men vary by training status but are similar in PBMCs and skeletal muscle: A pilot study. 男性对剧烈耐力运动的自噬反应因训练状态而异，但在pbmc和骨骼肌中是相似的：一项初步研究。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71064

Jonathan W Specht, Jeremy B Ducharme, Alyssa R Bailly, Michael R Deyhle

{"title":"Autophagic responses to vigorous endurance exercise in men vary by training status but are similar in PBMCs and skeletal muscle: A pilot study.","authors":"Jonathan W Specht, Jeremy B Ducharme, Alyssa R Bailly, Michael R Deyhle","doi":"10.14814/phy2.71064","DOIUrl":"https://doi.org/10.14814/phy2.71064","url":null,"abstract":"Vigorous exercise triggers signaling cascades that activate autophagy markers like the degradation of sequestosome 1 (p62) and accumulation of Light Chain 3 II (LC3II). Limited human data exist on autophagic responses across different local and systemic tissues and how training status affects these relationships. This study investigates the vigorous exercise-induced changes in p62 and LC3II expression in peripheral blood mononuclear cells (PBMCs) and skeletal muscle between endurance-trained and untrained men. Twelve men (endurance-trained n = 7, untrained n = 5) completed 60 min of cycling at their second ventilatory threshold. Skeletal muscle biopsy samples and PBMCs were collected pre- and 3-h post-exercise and analyzed for p62 and LC3II protein expression. We found significant interaction effects of time and training status for p62 (p < 0.001) and LC3II (p = 0.002). In untrained men, p62 decreased in PBMCs (FC = 0.50 ± 0.14; p < 0.001) and skeletal muscle (FC = 0.57 ± 0.21; p < 0.001), while LC3II increased in both tissues (FC = 1.74 ± 0.79; p = 0.019 for PBMCs; FC = 1.69 ± 0.47; p = 0.033 for skeletal muscle). No changes were observed in endurance-trained men (all p > 0.05). These results suggest that a bout of vigorous endurance exercise increased autophagy-related markers in both skeletal muscle and PBMCs in the untrained men only, suggesting a diminished autophagic response in the trained men.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71064"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventricular arrhythmogenesis in pulmonary hypertension: From right ventricular remodeling to clinical implications. 肺动脉高压的室性心律失常：从右心室重构到临床意义。

IF 2.1

Physiological Reports Pub Date : 2026-08-01 DOI: 10.14814/phy2.71067

Abdulkadir Kiris, Peng Zhang, Peter Bronk, Bum-Rak Choi, Gaurav Choudhary

{"title":"Ventricular arrhythmogenesis in pulmonary hypertension: From right ventricular remodeling to clinical implications.","authors":"Abdulkadir Kiris, Peng Zhang, Peter Bronk, Bum-Rak Choi, Gaurav Choudhary","doi":"10.14814/phy2.71067","DOIUrl":"https://doi.org/10.14814/phy2.71067","url":null,"abstract":"Pulmonary hypertension (PH) results in chronic pressure overload of the right ventricle, leading to progressive structural, metabolic, neurohumoral, and electrophysiological remodeling. Although right ventricular failure is the major determinant of outcomes in PH, these remodeling processes may also create a substrate for ventricular arrhythmogenesis, thereby contributing to poor outcomes. While atrial arrhythmias are more common, ventricular arrhythmias (VAs) have also been reported in PH and may have important clinical implications. However, their epidemiology, mechanisms, and optimal management remain incompletely understood. This review summarizes pathophysiological mechanisms of VAs in PH by integrating findings from preclinical and clinical investigations. Available data show that premature ventricular contractions and non-sustained ventricular tachycardia are the most frequently reported VAs, whereas sustained ventricular tachycardia and ventricular fibrillation appear to be uncommon. Arrhythmia susceptibility in PH is associated with several mechanisms that provide possible therapeutic targets. These include changes in specific ion channels in the right ventricle, abnormalities in calcium handling, structural remodeling characterized by hypertrophy, fibrosis and gap junction alterations, autonomic nervous system imbalance, myocardial ischemia, inflammation, and oxidative stress. We discuss the translational implications of these findings and highlight gaps in knowledge to guide future research on the epidemiology, targeted management, and prognostic significance of VAs in PH.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 16","pages":"e71067"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0