Physiological Reports最新文献_第8页

The influence of sex on activity in voluntary wheel running, forced treadmill running, and open field testing in mice.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70246

Adam J Janowski, Giovanni Berardi, Kazuhiro Hayashi, Ashley N Plumb, Joe B Lesnak, Tahsin Khataei, Ben Martin, Christopher J Benson, Kathleen A Sluka

{"title":"The influence of sex on activity in voluntary wheel running, forced treadmill running, and open field testing in mice.","authors":"Adam J Janowski, Giovanni Berardi, Kazuhiro Hayashi, Ashley N Plumb, Joe B Lesnak, Tahsin Khataei, Ben Martin, Christopher J Benson, Kathleen A Sluka","doi":"10.14814/phy2.70246","DOIUrl":"10.14814/phy2.70246","url":null,"abstract":"Physical activity is commonly used for both measuring and treating dysfunction. While preclinical work has been historically biased towards males, the inclusion of both males and females is gaining popularity. With the increasing inclusion of both sexes, it is imperative to determine sex differences in common behavioral assays. This was a secondary analysis of healthy naïve mice to determine baseline sex differences in three activity assays: voluntary wheel running (32 mice), forced treadmill running (178 mice), and open field (88 mice). In voluntary wheel running, females showed greater distance run, running time, bout duration, and speed, but no difference in total bouts. In forced treadmill running, females showed greater time to exhaustion, but no difference in maximum speed attained. In open field, males showed greater active time but no difference in distance and speed over 30 min; however, male mice showed a downward trajectory in distance and speed over the final 20 min of testing, whereas females did not. These data suggest that male mice demonstrate comparable activity intensity to female mice but do not match females' duration of activity, especially for volitional tasks. Researchers utilizing these assays should account for sex differences as they could mask true findings in an experiment.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70246"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with TGF-β1.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70249

Tyrone L R Humphries, Soobin Lee, Aaron J Urquhart, David A Vesey, Aaron S Micallef, Clay Winterford, Andrew J Kassianos, Graham J Galloway, Ross S Francis, Glenda C Gobe

{"title":"Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with TGF-β1.","authors":"Tyrone L R Humphries, Soobin Lee, Aaron J Urquhart, David A Vesey, Aaron S Micallef, Clay Winterford, Andrew J Kassianos, Graham J Galloway, Ross S Francis, Glenda C Gobe","doi":"10.14814/phy2.70249","DOIUrl":"10.14814/phy2.70249","url":null,"abstract":"Tubulointerstitial fibrosis is a characteristic hallmark of chronic kidney disease (CKD). Metabolic perturbations in cellular energy metabolism contribute to the pathogenesis of CKD, but the chemical contributors remain unclear. The aim of this investigation was to use two dimensional 1H-nuclear magnetic resonance (2D-COSY) metabolomics to identify the chemical changes of kidney fibrogenesis. An in vitro transforming growth factor-β1 (TGF-β1)-induced model of kidney fibrogenesis with human kidney-2 (HK-2) proximal tubular epithelial cells (PTEC) was used. The model was validated by assaying for various pro-fibrotic molecules, using quantitative PCR and Western blotting. 2D-COSY was performed on treated cells. Morphological and functional changes characteristic of tubulointerstitial fibrosis were confirmed in the model; expression of fibronectin, collagen type IV, smooth muscle actin, oxidative stress enzymes increased (p < 0.05). NMR metabolomics provided evidence of altered metabolite signatures associated with glycolysis and glutamine metabolism, with decreased myo-inositol and choline, and metabolites of the oxidative phase of the pentose phosphate pathway with increased glucose and glucuronic acid. The altered PTEC cellular metabolism likely supports the rapid fibrogenic energy demands. These results, using 2D-COSY metabolomics, support development of a biomarker panel of fibrosis detectable using clinical magnetic resonance spectroscopy to diagnose and manage CKD.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70249"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of passive heating garments worn in temperate and cold conditions prior to simulated performance for male soccer substitutes.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70189

Gavin Cowper, Stuart Goodall, Kirsty M Hicks, Louise Burnie, Kai Fox, David Duffy, Marc A Briggs

{"title":"The influence of passive heating garments worn in temperate and cold conditions prior to simulated performance for male soccer substitutes.","authors":"Gavin Cowper, Stuart Goodall, Kirsty M Hicks, Louise Burnie, Kai Fox, David Duffy, Marc A Briggs","doi":"10.14814/phy2.70189","DOIUrl":"10.14814/phy2.70189","url":null,"abstract":"Lengthy periods of inactivity are experienced by substitutes during a soccer match, which can decrease muscle temperature, ultimately impacting performance. This study aimed to determine the effects of using a passive heat intervention in both a cold (2°C) and thermoneutral (18°C) environment on simulated soccer performance and perceptual responses. On four occasions, 14 trained male players, completed a pre-match warm-up, followed by 45 min of rest. After, players completed a half-time re-warm-up, followed by an additional 15 min of rest, simulating 60 min as a substitute. During these periods, players wore tracksuit bottoms (CON), or heated trousers (HEAT), over soccer attire. Once 60 min concluded, participants performed a Soccer Match Simulation (SMS) to assess physical performance. HEAT improved 15 m sprint performance in 2°C (2.8%; p < 0.001) and 18°C (2.6%; p < 0.001) conditions. Further, in HEAT, a significant trial and time effect on countermovement jump height and repeated sprint performance was observed in both 2 and 18°C. Upon match entry, participants felt warmer (p < 0.01), more comfortable (p < 0.01), and felt an increase in match readiness following HEAT, during both conditions. Applying heated garments before match entry for soccer substitutes positively impacts physical performance and match readiness in thermoneutral and cold environments.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70189"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of home-based exercise with or without a Mediterranean-style diet on adiposity markers in postmenopausal women: A randomized-control trial.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70239

Abbigail Tan, Gareth Dunseath, Rebecca L Thomas, Sarah L Prior, Richard M Bracken, Rachel Churm

{"title":"Effect of home-based exercise with or without a Mediterranean-style diet on adiposity markers in postmenopausal women: A randomized-control trial.","authors":"Abbigail Tan, Gareth Dunseath, Rebecca L Thomas, Sarah L Prior, Richard M Bracken, Rachel Churm","doi":"10.14814/phy2.70239","DOIUrl":"10.14814/phy2.70239","url":null,"abstract":"Advancing age and estrogen deficiency increases susceptibility of post-menopausal women (PMW) to abdominal obesity and manifestation of cardiometabolic disease. There is limited evidence on the effect of lifestyle interventions on adiposity markers within at-risk PMW. Therefore, this study aims to evaluates an 8-weeks of home-based, equipment-free, interval training (HEFIT) with or without Mediterranean-style diet (MD) on adiposity markers in physically inactive, postmenopausal women with overweight/obesity. Thirty PMW (56.7 ± 3.9 years, BMI: 30.5 ± 5.2 kg/m2) were randomly assigned to three groups: (i) Ex; HEFIT thrice weekly/week, (ii) EX + MD, or (iii) CTL; control. Visceral Adiposity Index (VAI), body weight, BMI, waist and hip circumference (WC; HC), visceral adipose tissue (VAT), total body fat percentage, leptin, and adiponectin were determined pre- and post-8-week intervention. There was no significant between group effect on VAI. Compared to CTL, a significant between group reduction was seen in weight, BMI, and WC in both EX and EX+D (p < 0.05). Leptin and adiponectin remained unchanged in all groups (p > 0.05). Adherence rates were 85% and 96% for EX and EX+MD, respectively, and 80% of EX+D of participants had optimal adherence to diet. Concluding HEFIT with or without dietary changes could improve adiposity in overweight/obese postmenopausal women.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70239"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcutaneous auricular vagus nerve stimulation inhibits mental stress-induced cortisol release-Potential implications for inflammatory conditions.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70251

Ely Cuberos Paredes, Domenica Goyes, Sadie Mak, Raffi Yardimian, Nickolas Ortiz, Ayana McLaren, Harald M Stauss

{"title":"Transcutaneous auricular vagus nerve stimulation inhibits mental stress-induced cortisol release-Potential implications for inflammatory conditions.","authors":"Ely Cuberos Paredes, Domenica Goyes, Sadie Mak, Raffi Yardimian, Nickolas Ortiz, Ayana McLaren, Harald M Stauss","doi":"10.14814/phy2.70251","DOIUrl":"10.14814/phy2.70251","url":null,"abstract":"Elevated glucocorticoid levels with reduced glucocorticoid responsiveness have been reported in chronic inflammatory conditions. Activation of neurons in the nucleus of the solitary tract by transcutaneous auricular vagus nerve stimulation (taVNS) may activate inhibitory pathways projecting to the hypothalamic paraventricular nucleus (PVN), thus inhibiting corticotropin-releasing hormone (CRH) release and improving glucocorticoid dysfunction in chronic inflammatory conditions. Healthy adults (n = 12) participated in experimental (taVNS) and control (sham-taVNS) sessions at least 4 days apart. A 30-min baseline recording was followed by 30 min of taVNS or sham-taVNS and 40 min of recovery. Ten minutes into taVNS or sham-taVNS, a mental arithmetic stress test (MAST) was conducted for 15 min. The MAST increased heart rate, low frequency (LF) heart rate variability (HRV), and the LF to high frequency ratio of HRV, confirming sympathetic activation. Salivary cortisol levels during the MAST were lower during taVNS (49.5 ± 48.0% from baseline; mean ± SD) compared to sham-taVNS (106.0 ± 81.1% from baseline; mean ± SD; p < 0.05). In a psoriasis patient, daily taVNS for 3 months reduced diurnal salivary cortisol levels from 58.2 ± 35.2 (ng/mL)*h (mean ± SD) to 34.9 ± 13.8 (ng/mL)*h (mean ± SD). While it is possible that taVNS inhibited CRH-releasing neurons in the PVN, our study design did not allow to confirm this potential mechanism.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70251"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the therapeutic potential of vagus nerve stimulation in autoimmune diseases: A systematic review.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70230

Eubi Chan, Ali R Mani

{"title":"Assessing the therapeutic potential of vagus nerve stimulation in autoimmune diseases: A systematic review.","authors":"Eubi Chan, Ali R Mani","doi":"10.14814/phy2.70230","DOIUrl":"10.14814/phy2.70230","url":null,"abstract":"Emerging evidence suggests that the vagus nerve can modulate the immune system in experimental settings. Vagus nerve stimulation (VNS), initially developed for managing epilepsy, is now being explored as a treatment for autoimmune diseases due to its potential immunomodulatory effects. This systematic review evaluates the therapeutic potential of VNS in autoimmune diseases by critically appraising findings from human clinical studies. This systematic review was conducted in accordance with the PRISMA guideline, with a comprehensive literature search performed in Ovid, Cochrane, and PubMed databases up to July 2024. Studies focusing on VNS in patients with autoimmune diseases were eligible, and the quality of study was assessed using the QualSyst tool. Of the 53 papers identified for full-text assessment, 19 studies met the eligibility criteria. Findings suggest that VNS is a promising adjunctive therapy for Crohn's disease and rheumatoid arthritis, showing potential to alleviate symptoms and modulate immune responses. The efficacy and safety of VNS vary widely across studies, highlighting the complex nature of autoimmune diseases and the diverse mechanisms of VNS action. Future research should prioritize large-scale, randomized controlled trials with standardized protocols to further elucidate the efficacy, long-term safety, and optimal parameters of VNS across various autoimmune conditions.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70230"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation properties and respiratory frequency of ECG-derived heart rate variability during multiple race-pace running intervals in female and male long-distance runners.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70177

Thomas Gronwald, Marcelle Schaffarczyk, Dominik Fohrmann, Olaf Hoos, Karsten Hollander

{"title":"Correlation properties and respiratory frequency of ECG-derived heart rate variability during multiple race-pace running intervals in female and male long-distance runners.","authors":"Thomas Gronwald, Marcelle Schaffarczyk, Dominik Fohrmann, Olaf Hoos, Karsten Hollander","doi":"10.14814/phy2.70177","DOIUrl":"10.14814/phy2.70177","url":null,"abstract":"Aim was to evaluate alterations of the non-linear short-term scaling exponent alpha1 of detrended fluctuation analysis (DFAa1) of heart rate (HR) variability (HRV) as a sensitive marker for assessing global physiological demands during multiple running intervals. As a secondary analysis, agreement of ECG-derived respiratory frequency (EDR) compared to respiratory frequency (RF) derived from the metabolic cart was evaluated with the same chest belt device. Fifteen trained female and male long-distance runners completed four running bouts over 5 min on a treadmill at marathon pace. During the last 3 min of each bout gas exchange data and a single-channel ECG for the determination of HR, DFAa1 of HRV, EDR and RF were analyzed. Additionally, blood lactate concentration (BLC) was determined and rating of perceived exertion (RPE) was requested. DFAa1, oxygen consumption, BLC, and RPE showed stable behaviors comparing the running intervals. Only HR (p < 0.001, d = 0.17) and RF (p = 0.012, d = 0.20) indicated slight increases with small effect sizes. In addition, results point towards inter-individual differences in all internal load metrics. The comparison of EDR with RF during running revealed high correlations (r = 0.80, p < 0.001, ICC3,1 = 0.87) and low mean differences (1.8 ± 4.4 breaths/min), but rather large limits of agreement with 10.4 to -6.8 breaths/min. Results show the necessity of EDR methodology improvement before being used in a wide range of individuals and sports applications. Relationship of DFAa1 to other internal load metrics, including RF, in quasi-steady-state conditions bears the potential for further evaluation of exercise prescription and may enlighten decoupling mechanisms during prolonged exercise bouts.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70177"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organogermanium: Potential beneficial effects on the cardiovascular system.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70234

Kunihiko Aizawa, Takashi Nakamura, Yasuhiro Shimada, Tomoya Takeda, Junya Azumi, Angela C Shore

{"title":"Organogermanium: Potential beneficial effects on the cardiovascular system.","authors":"Kunihiko Aizawa, Takashi Nakamura, Yasuhiro Shimada, Tomoya Takeda, Junya Azumi, Angela C Shore","doi":"10.14814/phy2.70234","DOIUrl":"10.14814/phy2.70234","url":null,"abstract":"Organogermanium, especially poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132), has been known to enhance immune-modulatory activities. However, the in vivo and in vitro evidence accumulated over the last 20 years reveals that Ge-132 has unique but underappreciated multi-functional properties that have a potential positive effect for the cardiovascular system. A hydrolysate of Ge-132, monomeric 3-(trihydroxygermyl)propanoic acid, forms a complex with a vicinal diol structure (i.e., having two adjacent hydroxyl groups such as the cis-diol and catechol groups) that exists in ribose (e.g., adenosine triphosphate), catecholamine (e.g., adrenaline), and saccharide (e.g., glucose). Additionally, Ge-132 enhances macrophage phagocytosis and the heme catabolic pathway by upregulating key enzymes that are responsible for producing cytoprotective molecules such as biliverdin and bilirubin during the process. These multi-functional properties exert pleiotropic physiological effects after an oral intake of Ge-132 such as anti-oxidation, anti-inflammation, anti-hypertensive, anti-glycation, and erythrocyte lifecycle enhancement, all of which appear to assist the cardiovascular system. Of those effects, the effects on the lifecycle of erythrocyte may have an important implication for maintaining optimal vascular function, augmenting the availability of oxygen by enhancing the elimination of senescent, and damaged erythrocytes as well as promoting erythropoiesis. Human studies are warranted to determine whether these beneficial effects observed in previous studies are translated into humans.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70234"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant activity and protective effect of phyto-active compounds of Crataegus azarolus berries decoction extract against acetic acid-induced hepatorenal injuries in male rats.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70240

Houcem Sammari, Anouar Abidi, Saber Jedidi, Nourhen Dhawefi, Hichem Sebai

{"title":"Antioxidant activity and protective effect of phyto-active compounds of Crataegus azarolus berries decoction extract against acetic acid-induced hepatorenal injuries in male rats.","authors":"Houcem Sammari, Anouar Abidi, Saber Jedidi, Nourhen Dhawefi, Hichem Sebai","doi":"10.14814/phy2.70240","DOIUrl":"10.14814/phy2.70240","url":null,"abstract":"The present study evaluated the hepato-nephronal protective properties of Crataegus azarolus berries decoction extract (CAB-DE) on acetic acid (AA)-induced oxidative stress and metabolic disorders in rats. Animals (60 rats) were randomly divided into six groups (n = 10), with groups 1 and 2 being controls and groups 3, 4, and 5 given increasing doses of CAB-DE, group 6 were given gallic acid until ulcerative colitis was induced and then intoxicated by an acute intra-rectal infusion of AA. Our results showed that CAB-DE-oral administration had no signs of toxicity or abnormal behavior in rats, with a LD50 higher than 3500 mg/kg bw. In addition, CAB-DE protected against AA-induced nephropathy and hepatic damage in rats, as determined by an increase in organ weights and an alteration in the renal and liver parameters and functions. Moreover, extract co-administration reduced AA-induced liver and kidney lipoperoxidation, maintained non-enzymatic contents such as sulfhydryl groups (-SH) and reduced glutathione (GSH), and restored antioxidant enzyme activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Finally, CAB-DE might have a possible protective effect against AA-oxidative stress and dysfunction in the rat liver and kidney, suggesting that Crataegus azarolus berries may be beneficial for people suffering from liver issues and nephropathy.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70240"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D and its relationship to performance and health during a competitive period in elite women's basketball and volleyball players.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70224

Álvaro Miguel-Ortega, Julio Calleja-González, Juan Mielgo-Ayuso

{"title":"Vitamin D and its relationship to performance and health during a competitive period in elite women's basketball and volleyball players.","authors":"Álvaro Miguel-Ortega, Julio Calleja-González, Juan Mielgo-Ayuso","doi":"10.14814/phy2.70224","DOIUrl":"10.14814/phy2.70224","url":null,"abstract":"Vitamin D [25(OH)D] is a key nutrient, although its level is often low in the general population. To investigate the relationship between vitamin D levels and muscle performance, and to analyze how vitamin D changes during a 16-week competitive season and its relationship to the performance tests performed. Participant characteristics: age 25.1 ± 4.7 years; height 1.8 ± 0.1 m, and body mass 73.9 ± 15.4 kg. Vitamin D levels (ng/mL) were at T1 (September): 33.7 ± 14.7 (n = 23), and at T2 (January): 26.1 ± 7.3 (n = 23). Over 16 weeks of competition, participants' blood was analyzed to determine their vitamin D levels. Their athletic abilities were evaluated through various tests: vertical jumps (standing jump and countermovement jump); 20-m sprint without direction changes; and intermittent endurance test; the vitamin D level decreased from T1 to T2 by -22. 40% [p < 0.05] but performance improved in all tests performed (SJ: 4.57%; CMJ: 6.94%; VO2max: 4.99% [p < 0.05]; 20 m: -1.83%). There is a relationship between vitamin D levels and physical performance in female indoor athletes. The results suggest that increased training load may also negatively affect vitamin D levels in elite female indoor athletes.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70224"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0