Physiological Reports最新文献_第3页

Integrative bioinformatic analysis identifies an extracellular matrix gene signature linked to muscle adaptation to endurance and resistance training. 综合生物信息学分析确定了与肌肉适应耐力和阻力训练有关的细胞外基质基因特征。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70874

Muhammad Isman Sandira, Firman Hasan, Tsubasa Shibaguchi, Hanafi Idris, Mukti Mukhtar, Kazumi Masuda

{"title":"Integrative bioinformatic analysis identifies an extracellular matrix gene signature linked to muscle adaptation to endurance and resistance training.","authors":"Muhammad Isman Sandira, Firman Hasan, Tsubasa Shibaguchi, Hanafi Idris, Mukti Mukhtar, Kazumi Masuda","doi":"10.14814/phy2.70874","DOIUrl":"10.14814/phy2.70874","url":null,"abstract":"Skeletal muscle exhibits a remarkable adaptive capacity; endurance training enhances mitochondrial capacity, whereas resistance training improves mechanical strength. Despite these differences, both training impose repeated contractile and remodeling demands on skeletal muscle, suggesting a conserved transcriptional response that may underpin the muscle's capacity to endure long-term training. However, a systematic analysis of the universal gene signature common to both training types has not yet been conducted. We therefore reanalyzed microarray datasets from human skeletal muscle samples obtained before and after endurance and resistance training. We first identified differentially expressed genes in each dataset, then performed a cross-dataset comparison to determine reproducible transcriptional responses across heterogeneous training protocols. Our results identified extracellular matrix (ECM) remodeling-related genes as conserved transcriptional responses to both endurance and resistance training. Moreover, we observed modality-associated gene signatures: endurance training was associated with ECM-adhesion and matrix connectivity, whereas resistance training preferentially promoted ECM structural maturation and reinforcement. These findings suggest that ECM-centered transcriptional regulation is a conserved and reproducible feature of skeletal muscle responses to both endurance and resistance training. The central role of ECM remodeling in the plasticity of human skeletal muscle establishes a comprehensive framework for future mechanistic investigations into how exercise induces cellular adaptations.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70874"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues. 下丘脑外组织自分泌食欲能信号的生理意义。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70892

Jean Claude Hakizimana, Makinde Vincent Olubiyi, Abdullateef Isiaka Alagbonsi

{"title":"Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues.","authors":"Jean Claude Hakizimana, Makinde Vincent Olubiyi, Abdullateef Isiaka Alagbonsi","doi":"10.14814/phy2.70892","DOIUrl":"https://doi.org/10.14814/phy2.70892","url":null,"abstract":"Orexin-A and orexin-B, originally discovered as hypothalamic neuropeptides, have been detected in extra-hypothalamic tissues together with their receptors (OX1R and OX2R) since the early 2000s. This systematic review is the first to comprehensively synthesize evidence on the autocrine/paracrine effects of locally produced orexin across extra-hypothalamic tissues. Following PRISMA 2020 guidelines, a systematic search was conducted in PubMed, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Google Scholar. Eligible studies were original, full-text, peer-reviewed articles reporting primary data on prepro-orexin/orexin peptide and/or OX1R/OX2R expression in non-neuronal extra-hypothalamic tissues, with evidence of co-expression within the same cell/tissue or functional effects reasonably attributable to locally produced orexin. From the 10 eligible studies, autocrine orexinergic signaling was functionally demonstrated in the adrenal gland (steroidogenesis via Gq/PLC/IP3/Ca2+), male reproductive tract (testosterone secretion), adipose tissue (lipolysis/thermogenesis), heart (myocardial protection via PI3K/Akt/eNOS), pancreas (glucose-regulated insulin/glucagon modulation), and liver (lipogenesis via ERK1/2). OX1R primarily activates the Gq/PLC/IP3/Ca2+ pathway, resulting in ERK1/2 and p38 MAPK signaling (promoting secretion and proliferation), while OX2R couples to Gs/Gi, modulating cAMP and PI3K/Akt (favoring cytoprotection and anti-apoptosis). Autocrine orexinergic signaling constitutes a legitimate, compartment-autonomous regulatory mechanism in peripheral tissues, enabling rapid, tissue-specific responses insulated from central fluctuations.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70892"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transitional feeding in developing pigs: Effects of food texture modification on liquid swallowing behavior and epiglottic movements. 发育中猪的过渡喂养：食物质地修饰对液体吞咽行为和会厌运动的影响。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70878

Stephane J Montuelle, Donna R Scarborough, Hannah R Baker, Susan H Williams

{"title":"Transitional feeding in developing pigs: Effects of food texture modification on liquid swallowing behavior and epiglottic movements.","authors":"Stephane J Montuelle, Donna R Scarborough, Hannah R Baker, Susan H Williams","doi":"10.14814/phy2.70878","DOIUrl":"10.14814/phy2.70878","url":null,"abstract":"Food texture modifications facilitate the transition from suckling to chewing. We examined drinking and liquid swallowing in 2 groups of pigs: one group directly transitioned from liquids to solids (DT) and the other transitioned progressively (PT) from liquids to soft foods then to solids. Our study reports the typical outcome of maturation of oropharyngeal physiology in both groups with similarities in the behavioral aspects of liquid swallowing (swallows occur during ingestion cycles, similar cycle frequency). However, compared to DT pigs, PT pigs used fewer gape cycles and less time between swallows and initiated the swallow later in the gape cycle, which are characteristics of swallow in younger pigs. Swallows in PT pigs were also typically faster with shorter epiglottal descent duration to reach laryngeal vestibule closure (LVC) quicker, thus increasing LVC duration significantly relative to swallow duration. Furthermore, throughout the study, epiglottal descent duration decreased in PT pigs but increased in DT pigs, emphasizing how each transition strategy altered the maturation of a key component of the swallow. Our results expand our understanding of liquid swallowing behavior in mammals and showcase how food-texture modification during a critical period of development can impact the maturation of swallow physiology.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70878"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postweaning diet affects offspring metabolic outcomes more than maternal diet in male and female mice. 在雄性和雌性小鼠中，断奶后饮食比母体饮食更能影响后代的代谢结果。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70881

Adam Corken, Elizabeth C Wahl, James D Sikes, Keshari M Thakali

{"title":"Postweaning diet affects offspring metabolic outcomes more than maternal diet in male and female mice.","authors":"Adam Corken, Elizabeth C Wahl, James D Sikes, Keshari M Thakali","doi":"10.14814/phy2.70881","DOIUrl":"10.14814/phy2.70881","url":null,"abstract":"The pervasiveness of obesity necessitates expanded pursuits to understand mechanistic drivers of the condition. Maternal diet during conception and gestation can program offspring towards excessive weight gain. Furthermore, the association between obesity and hypertension suggests that maternal programming may impact offspring vascular reactivity. We investigated whether a maternal high fat+sucrose diet (HFD) prior and during pregnancy and lactation affected offspring body composition, metabolic parameters, and vascular reactivity. Using C57BLJ/6 mice, male and female offspring from control (low fat/sucrose) and HFD fed mothers were fed either a control or HFD for 14 weeks after weaning. After 14 weeks of postweaning diets, linear mixed effect modeling adjusting for sex and litter revealed that offspring HFD and sex were significant drivers of body composition changes, non-fasting serum insulin, serum leptin, and metabolic measures (respiratory exchange ratio, energy expenditure, and food intake). Offspring sex had significant effects on fasting glucose and non-fasting triglycerides. Neither maternal nor offspring diet or sex had significant effects on mesenteric artery contractility in the presence or absence of perivascular adipose fat. In conclusion, in our experimental paradigm, offspring diet and sex effects on body composition and metabolic parameters overshadowed maternal HFD programming in male and female offspring.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70881"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating elastin crosslinking desmosines are associated with arterial wall degradation in older adults with atherosclerosis. 在老年动脉粥样硬化患者中，循环弹性蛋白交联桥苷与动脉壁降解有关。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70854

Hana Inoue, Lisa Takahashi, Hirofumi Tomiyama, Arisa Araki, Toshitaka Nagao, Taishiro Chikamori, Toyonobu Usuki, Utako Yokoyama

{"title":"Circulating elastin crosslinking desmosines are associated with arterial wall degradation in older adults with atherosclerosis.","authors":"Hana Inoue, Lisa Takahashi, Hirofumi Tomiyama, Arisa Araki, Toshitaka Nagao, Taishiro Chikamori, Toyonobu Usuki, Utako Yokoyama","doi":"10.14814/phy2.70854","DOIUrl":"10.14814/phy2.70854","url":null,"abstract":"Elastin, an extracellular matrix component that contributes to vascular integrity, is progressively degraded during vascular injury including atherosclerosis. We assessed circulating desmosine (DES) and isodesmosine (IDES), elastin-specific crosslinking amino acids, as indicators of arterial elastin degradation by isotope-dilution liquid chromatography-tandem mass spectrometry. Thirty-eight patients with atherosclerotic ischemic heart disease (IHD) and 30 age- and sex-matched healthy controls were enrolled. Plasma concentrations of both DES and IDES were significantly higher in IHD patients than in controls. The area under the receiver operating characteristic curve for total desmosines (DES + IDES) was 0.763. Multivariable analysis revealed that traditional risk factors for atherosclerosis were not significantly associated with plasma concentrations of desmosines. These findings suggest that circulating desmosines reflect arterial wall degeneration in atherosclerosis and are independent of traditional risk factors.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 7","pages":"e70854"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiorespiratory coupling tightens with workload during graded exercise: A pilot study with adolescent athletes. 在分级运动中，心肺耦合随着工作量的增加而收紧：一项针对青少年运动员的初步研究。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70884

Lizeth Avila-Gutierrez, Eric Alonso Abarca-Castro, Ashuin Kammar-García, Otniel Portillo-Rodríguez, José Javier Reyes-Lagos

{"title":"Cardiorespiratory coupling tightens with workload during graded exercise: A pilot study with adolescent athletes.","authors":"Lizeth Avila-Gutierrez, Eric Alonso Abarca-Castro, Ashuin Kammar-García, Otniel Portillo-Rodríguez, José Javier Reyes-Lagos","doi":"10.14814/phy2.70884","DOIUrl":"https://doi.org/10.14814/phy2.70884","url":null,"abstract":"Cardiorespiratory coupling (CRC) reflects coordination between heart and lung function, but how it changes with increasing intensity during graded exercise remains unclear. We investigated CRC as real-time covariation between cardiac timing and breath-by-breath pulmonary oxygen uptake (VO2) to test whether coupling strengthens with workload in adolescent athletes. We conducted an observational, within-subject analysis of the ACTES cycling dataset. Eighteen adolescents cycled at 50, 110, and 140 W. Beat-to-beat RR intervals and pulmonary VO2 time series were examined in ultra-short 60 s segments. Fluctuations were summarized using SDRR/RMSSD and SDVO2/RMSSDVO2. CRC was measured using joint symbolic dynamics (JSD; Shannon entropy, SE, and Miller-Madow-corrected entropy, CSE) and the highest normalized cross-correlation (X-Corr). Mean RR decreased and mean pulmonary VO2 increased with workload (both p < 0.0001). SDRR and RMSSD were lower at 110 and 140 W versus 50 W; SDVO2 declined from 50 to 110/140 W, whereas RMSSDVO2 was unchanged. X-Corr increased from 50 to 110/140 W (p ≤ 0.0014). JSD indices decreased as workload increased (SE: global p = 0.139; CSE: global p = 0.029), suggesting tighter CRC. CRC becomes more pronounced with increased workload, aligning with reduced heart rate variability and reflecting vagal withdrawal and reflex responses that improve heart-lung integration in adolescent athletes.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70884"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID. 长冠状病毒成人亚极限运动时外周氧输送受损。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70873

Callum Thomas, Ruth E Ashton, Rebecca Owen, Ethan McNeil-Angopa, Jack Carr, Thomas Bewick, Mark A Faghy

{"title":"Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID.","authors":"Callum Thomas, Ruth E Ashton, Rebecca Owen, Ethan McNeil-Angopa, Jack Carr, Thomas Bewick, Mark A Faghy","doi":"10.14814/phy2.70873","DOIUrl":"https://doi.org/10.14814/phy2.70873","url":null,"abstract":"Long COVID (LC) is a multisystem condition that is linked to distinct pathologies including viral persistence, immunological dysfunction, endothelial damage, and mitochondrial dysfunction. To date, limited research has assessed peripheral tissue hypoxia to better understand LC symptom exacerbation. Forty-six people with LC and 10 controls (CON) completed two submaximal cardiopulmonary exercise tests (CPETs), separated by 24-h. Near-infrared spectroscopy (NIRS)-derived signals from the left gastrocnemius muscle were continuously monitored before, during, and after 2-day incremental CPET. CPET outcomes demonstrated impaired physical function on day 2 compared with day 1 for the LC cohort at rest and VT1. LC tissue saturation index (TSI%) remained elevated above rest for a shorter duration of exercise compared to CON on day 1 (2nd minute vs. 5th minute). On day 2, this response worsened for LC (Rest vs. 1st exercise minute: 63 ± 5% vs. 65 ± 5%; p < 0.05); meanwhile, CON exhibited sustained TSI% elevation throughout exercise above rest (Rest vs. 12th exercise minute: 62 ± 5% vs. 67 ± 4%; p < 0.05). LC TSI% remained elevated above rest for a shorter duration of exercise compared to CON, worsening for LC on day 2. LC showed rapid normalization of TSI%, suggesting impaired muscle oxygenation and recovery during repeated exercise.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70873"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between heart rate variability and estradiol, progesterone, and the estradiol/progesterone ratio across menstrual phases in healthy women. 健康女性经期心率变异性与雌二醇、黄体酮及雌二醇/黄体酮比值的相关性

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70887

Tara R Salih, Darya S Abdulateef

{"title":"Correlation between heart rate variability and estradiol, progesterone, and the estradiol/progesterone ratio across menstrual phases in healthy women.","authors":"Tara R Salih, Darya S Abdulateef","doi":"10.14814/phy2.70887","DOIUrl":"https://doi.org/10.14814/phy2.70887","url":null,"abstract":"Heart rate variability (HRV) is widely used to assess cardiac health, yet uncertainty persists regarding HRV variations across the menstrual cycle and their association with reproductive hormones. Few studies have evaluated the full spectrum of HRV parameters, and most estimated menstrual phases from the last menstrual period without considering individual cycle length. This study aimed to compare HRV parameters across three menstrual phase groups, using accurate cycle tracking based on the next menstrual period and actual cycle length, and to correlate HRV with estradiol, progesterone, and the estradiol/progesterone (E/P) ratio. In 112 healthy women with regular cycles, HRV parameters were measured using a heart rate sensor, and serum hormone levels were obtained. Menstrual phase groups were defined using back-extrapolation from the next cycle. Data from 99 participants were analyzed: menstruation (n = 38), periovulatory (n = 30), and premenstrual phase (n = 31). HF was significantly higher during the peri-ovulatory phase, while estradiol and progesterone peaked premenstrually. The E/P ratio was highest pre-ovulatory. Estradiol correlated with most HRV measures; however, only the mean RR-interval in the premenstrual phase was statistically significant, with estradiol emerging as a negative independent predictor. These findings conclude notable HRV variation across menstrual phases and suggest that estradiol fluctuations may influence autonomic regulation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70887"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brachial blood flow and pressure responses are unrelated to the greater isometric handgrip tolerance of females compared to males. 肱血流量和压力反应与女性比男性更大的等距握力耐受性无关。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70871

João L Marôco, Joseph Scangas, Megan Borges, Eric Bracken, Anton Pecha, Tracy Baynard, Bo Fernhall

{"title":"Brachial blood flow and pressure responses are unrelated to the greater isometric handgrip tolerance of females compared to males.","authors":"João L Marôco, Joseph Scangas, Megan Borges, Eric Bracken, Anton Pecha, Tracy Baynard, Bo Fernhall","doi":"10.14814/phy2.70871","DOIUrl":"10.14814/phy2.70871","url":null,"abstract":"Isometric handgrip (IHG) training lowers blood pressure (BP), but sex differences in fatigability may be confounding. We hypothesized that the greater time-to-fatigue during IHG in females would relate to preserved brachial blood flow, with males exhibiting reductions in flow. Fifteen females and 14 males (18-32 years) completed a fatiguing IHG at 30% of maximum voluntary contraction (MVC). Brachial diameter and blood velocity were assessed with B-mode and Doppler ultrasound, and BP via beat-to-beat finger photoplethysmography. Both sexes exhibited similar non-significant increases in brachial flow during IHG (ΔHG-rest = 30 mL min-1, p = 0.200). Post-exercise hyperemia was greater in males (Δ15spost-rest = 182 mL min-1, 95% CI: 130-233 mL min-1, p < 0.001) than in females (Δ15spost-rest = 89 mL min-1, 95% CI: 39-138 mL min-1, p < 0.001). Despite the mean arterial pressure response being greater in males (Δ = 30 mmHg, 95% CI: 24-37 mmHg, p < 0.001; vs. Δ = 17 mmHg, 95% CI: 10-23 mmHg, p < 0.001), conductance was similar between sexes during IHG (p = 0.470). Time-to-fatigue was greater in females (243-s vs. 181-s, p = 0.021) and unrelated to flow. Controlling for MVC, brachial diameter, or arm circumference did not affect results. Brachial flow and pressor responses were unrelated to the greater fatigue resistance of young females. The greater post-exercise hyperemia in males suggests a greater ischemic stimulus, independent of blood flow.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70871"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of long-term high-altitude residence on cardiopulmonary function in asymptomatic men: A cross-sectional study. 长期高原居住对无症状男性心肺功能的影响：一项横断面研究。

IF 2.2

Physiological Reports Pub Date : 2026-04-01 DOI: 10.14814/phy2.70864

Fengjiao Yang, Weixing Tan, Yajun Tian, Qin Wu, Xiaomei Feng, Gangwei Hu, Ou Li

{"title":"Impact of long-term high-altitude residence on cardiopulmonary function in asymptomatic men: A cross-sectional study.","authors":"Fengjiao Yang, Weixing Tan, Yajun Tian, Qin Wu, Xiaomei Feng, Gangwei Hu, Ou Li","doi":"10.14814/phy2.70864","DOIUrl":"10.14814/phy2.70864","url":null,"abstract":"To evaluate altitude-stratified differences in static lung function, aerobic capacity, and exercise physiology under standardized normoxic conditions, and identify multiple predictors of peak oxygen uptake (VO2) reduction among asymptomatic men after prolonged residence at varying altitudes. We conducted a cross-sectional study of 103 asymptomatic men stratified by residential altitude: low (<2500 m; n = 35), high (2500-3500 m; n = 32), and very high (>3500 m; n = 36). All underwent spirometry, fasting blood tests, and symptom-limited cardiopulmonary exercise testing (CPET) in normoxia. Multiple linear regression identified independent predictors of peak VO2/kg. Very high-altitude residents had significantly lower peak VO2/kg (-13.4 mL·min-1·kg-1 vs. low altitude, p < 0.001), reduced oxygen pulse, and impaired small-airway function (MMEF, FEF75; p < 0.05), despite preserved ventilatory efficiency (VE/VCO2 slope, p = 0.782). Hemoglobin was elevated at higher altitudes; triglycerides were higher only above 3500 m. Age (β = -0.285), regular exercise (≥3 sessions/week; β = +3.648), and very high-altitude residence (β = -13.370) independently predicted peak VO2/kg (all p < 0.001; R2 = 0.739). Residence above 3500 m causes persistent cardiopulmonary impairment driven by circulatory limitations and smoking, despite preserved ventilatory efficiency. Normoxic assessment identifies regular exercise (≥3 sessions/week) as a key countermeasure against altitude-induced deconditioning. Prioritizing smoking cessation and mandatory exercise programs is therefore recommended for long-term health in high-altitude personnel.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 8","pages":"e70864"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0