Physiological Reports最新文献_第3页

Assessment of ventilation heterogeneity in severe asthma using phase-resolved functional lung magnetic resonance imaging. 应用相位分辨功能肺磁共振成像评估重度哮喘患者通气异质性。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70423

Chuan T Foo, David Langton, Graham M Donovan, Bruce R Thompson, Peter B Noble, Francis Thien

{"title":"Assessment of ventilation heterogeneity in severe asthma using phase-resolved functional lung magnetic resonance imaging.","authors":"Chuan T Foo, David Langton, Graham M Donovan, Bruce R Thompson, Peter B Noble, Francis Thien","doi":"10.14814/phy2.70423","DOIUrl":"https://doi.org/10.14814/phy2.70423","url":null,"abstract":"Ventilation heterogeneity is a hallmark of asthma. This study examines the feasibility of phase-resolved functional lung magnetic resonance imaging (PREFUL MRI) in the evaluation of ventilation heterogeneity in severe asthma, its response to bronchodilator, and correlation with spirometry. Twenty-three patients with severe asthma and seven healthy volunteers completed PREFUL MRI and spirometry pre and post-bronchodilator. Ventilation heterogeneity was assessed using ventilation defect percentages (VDP) for regional ventilation (RVent) and flow-volume loop cross-correlation (FVL), interquartile distance (IQD), and inhomogeneity index (IHI). Patients exhibited a significantly higher pre-bronchodilator VDPRVent (19.9 ± 14.0 vs. 1.9 ± 1.9%, p < 0.001), VDPFVL (21.6 ± 15.9 vs. 1.7 ± 2.1%, p < 0.001), IQD (0.60 ± 0.25 vs. 0.30 ± 0.06, p < 0.001), and IHI (0.34 ± 0.12 vs. 0.18 ± 0.04, p < 0.001) compared to healthy volunteers. Post-bronchodilator, VDPRVent (14.7 ± 12.5 vs. 19.9 ± 14.0%, p = 0.02), IQD (0.51 ± 0.20 vs. 0.60 ± 0.25, p = 0.02), and IHI (0.30 ± 0.11 vs. 0.34 ± 0.12, p = 0.02) decreased significantly in patients but remained significantly higher than in healthy volunteers. Significant correlations were observed between pre-bronchodilator FEV1 and VDPRVent (ρ = -0.61, p < 0.001), VDPFVL (ρ = -0.73, p < 0.001), IQD (ρ = -0.57, p = <0.001), and IHI (ρ = -0.60, p < 0.001). PREFUL MRI derived markers of ventilation heterogeneity are worse in patients with asthma, improve post-bronchodilator, and correlate with the severity of airflow obstruction. These findings support the role of PREFUL MRI in assessing ventilation heterogeneity in asthma.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70423"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiopulmonary responses to acute exogenous ketosis at rest, and during submaximal and maximal exercise. 静息、亚极限和极限运动时对急性外源性酮症的心肺反应。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70397

Christopher D Crabtree, Justen Stoner, Alex Buga, Bradley Robinson, Drew Decker, Ashwini Chebbi, Xavier El-Shazly, Emily Murphy, Aydan Jordan, Teryn Bedell, Madison L Kackley, Tyler McClure, Yuchi Han, Orlando P Simonetti, Jeff S Volek

{"title":"Cardiopulmonary responses to acute exogenous ketosis at rest, and during submaximal and maximal exercise.","authors":"Christopher D Crabtree, Justen Stoner, Alex Buga, Bradley Robinson, Drew Decker, Ashwini Chebbi, Xavier El-Shazly, Emily Murphy, Aydan Jordan, Teryn Bedell, Madison L Kackley, Tyler McClure, Yuchi Han, Orlando P Simonetti, Jeff S Volek","doi":"10.14814/phy2.70397","DOIUrl":"10.14814/phy2.70397","url":null,"abstract":"Nutritional ketosis achieved through various methods in animals and humans has been shown to augment cardiac efficiency and function. However, this response during exercise has not been well characterized. Recreationally active adults (n = 12) completed a double blind, balanced, placebo-controlled, crossover study to examine the effects of bis-octanonyl (R)-1,3-butanediol (BO-BD) ingestion on cardiopulmonary function at rest and during a maximal oxygen consumption (V̇O2max) treadmill test (Bruce Protocol). Participants presented to the testing facility fasted. Capillary blood samples were obtained to measure glucose and beta-hydroxybutyrate (R-βHB) prior to consuming the BO-BD or a calorically matched placebo (PL) beverage. Metabolic and cardiovascular measures were collected every 15-30 min following beverage consumption. Participants began the V̇O2max test 120 min post-beverage ingestion. At rest, capillary R-βHB elevated rapidly after BO-BD ingestion and continued to steadily increase to 2.4 mM prior to the maximal exercise test. During the 120 min rest period, BO-BD increased resting heart rate (HR) (p = 0.001), ventilation (p < 0.001), and V̇O2 (p = 0.002) relative to PL. Although the total time to exhaustion was similar between conditions, V̇O2max was lower after BO-BD (p < 0.001). There were no differences in exercise lactate, RER, respiration, or rating of perceived exertion (RPE) between conditions. Compared to PL, BO-BD rapidly achieves nutritional ketosis, increases resting cardio-respiratory parameters, but somewhat paradoxically decreases peak aerobic exercise oxygen consumption despite achieving similar peak workloads.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70397"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between pulmonary artery pressure components in patients with advanced heart failure. 晚期心力衰竭患者肺动脉压各成分的关系。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70421

Denis Chemla, Antoine Beurnier, Marc Humbert, David Montani, Philippe Hervé

引用次数: 0

Gi-DREADD activation decreases Epithelial Na⁺ channel activity in renal principal cells. Gi-DREADD激活可降低肾主细胞上皮Na+通道活性。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70433

Tarek Mohamed Abd El-Aziz, Elena Mironova, James D Stockand, Lucia A Seale, Antonio G Soares

{"title":"Gi-DREADD activation decreases Epithelial Na+ channel activity in renal principal cells.","authors":"Tarek Mohamed Abd El-Aziz, Elena Mironova, James D Stockand, Lucia A Seale, Antonio G Soares","doi":"10.14814/phy2.70433","DOIUrl":"https://doi.org/10.14814/phy2.70433","url":null,"abstract":"The activity of the Epithelial Na+ Channel (ENaC) in renal principal cells (PC) fine-tunes sodium excretion and consequently affects blood pressure. G-coupled receptors play an important role in regulating ENaC activity. We previously explored the role of Gq and Gs in regulating ENaC activity by using the designer receptors exclusively activated by designer drugs (DREADD) technology. We demonstrated that pharmacogenetic activation of Gq (Gq-DREADD) exclusively in principal cells by Clozapine-N-oxide (CNO) reduced ENaC activity in renal tubules, promoting natriuresis that lowered elevated blood pressure in the DOCA-salt model of hypertension. In addition, by investigating the Gs-adenylyl cyclase-cAMP signal transduction pathway, we exhibited that treatment of PC-specific Gs-DREADD mice with CNO rapidly and significantly decreased urinary Na+ excretion. In this study, we investigate the role of Gi-DREADD in regulating ENaC activity. Our results showed that Gi-DREADD, expressed exclusively in renal principal cells, activated by CNO reduced ENaC activity and significantly increased urinary Na+ excretion compared to CNO-treated littermates. These findings provide for the first time that target activation of Gi signaling exclusively in PCs is sufficient to decrease ENaC activity and increase dependent urinary Na+ excretion in live animals.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70433"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The combined impact of chronic kidney disease and ulcer severity on incident cardiovascular events in patients with diabetes-related foot ulceration. 慢性肾脏疾病和溃疡严重程度对糖尿病相关足部溃疡患者心血管事件的综合影响

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70415

Nick S R Lan, Jonathan Hiew, Ivana Ferreira, J Carsten Ritter, Laurens Manning, P Gerry Fegan, Emma J Hamilton, Girish Dwivedi

{"title":"The combined impact of chronic kidney disease and ulcer severity on incident cardiovascular events in patients with diabetes-related foot ulceration.","authors":"Nick S R Lan, Jonathan Hiew, Ivana Ferreira, J Carsten Ritter, Laurens Manning, P Gerry Fegan, Emma J Hamilton, Girish Dwivedi","doi":"10.14814/phy2.70415","DOIUrl":"10.14814/phy2.70415","url":null,"abstract":"In patients with diabetes-related foot ulceration (DFU), ulcer severity and chronic kidney disease (CKD) portend worse outcomes. We evaluated the combined impact of a severe ulcer with CKD on major adverse cardiovascular events (MACE) in patients with DFU. Ulcer severity was defined using the SINBAD (site, ischaemia, neuropathy, bacterial infection, area, depth) classification, dividing into low (1-3) or high (4-6). CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2. Patients were categorized into four groups based on SINBAD and CKD category. MACE was defined as hospitalization for myocardial infarction, stroke or transient ischemic attack, or heart failure. Of 497 patients, 236 (47.5%) were SINBAD-low/CKD-absent, 80 (16.1%) SINBAD-high/CKD-absent, 127 (25.6%) SINBAD-low/CKD-present, and 54 (10.9%) SINBAD-high/CKD-present. The median follow-up was 410 (interquartile range 242-576) days for MACE and 387 (221-549) days for MACE or all-cause mortality. SINBAD-high/CKD-present was associated with significantly higher MACE (SINBAD-low/CKD-absent 4.2%; SINBAD-high/CKD-absent 7.5%; SINBAD-low/CKD-present 9.5%; SINBAD-high/CKD-present 33.3%; log-rank p < 0.001) and MACE or all-cause mortality (SINBAD-low/CKD-absent 5.5%; SINBAD-high/CKD-absent 13.8%; SINBAD-low/CKD-present 17.4%; SINBAD-high/CKD-present 53.7%; log-rank p < 0.001). SINBAD-high/CKD-present was associated with MACE (p < 0.001) and MACE or all-cause mortality (p < 0.001) after multivariate adjustment. Severe DFU with CKD amplifies the risk of MACE in patients with DFU, suggesting important implications for cardiovascular risk assessment.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70415"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incomplete reverse remodeling in pulmonary hypertension-induced right ventricular dysfunction in aged mice. 老年小鼠肺动脉高压引起的右心室功能障碍的不完全反向重构。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70422

Benjamin D McNair, Sushumna B Satyanarayana, Julian M Matthews, Sydney M Polson, Emma R Mehl, Joshua P Thornburg, Danielle R Bruns

{"title":"Incomplete reverse remodeling in pulmonary hypertension-induced right ventricular dysfunction in aged mice.","authors":"Benjamin D McNair, Sushumna B Satyanarayana, Julian M Matthews, Sydney M Polson, Emma R Mehl, Joshua P Thornburg, Danielle R Bruns","doi":"10.14814/phy2.70422","DOIUrl":"10.14814/phy2.70422","url":null,"abstract":"Right ventricular (RV) function is the strongest predictor of survival in pulmonary hypertension (PH) and age-related heart disease; however, no therapies improve RV function. Understanding how the RV undoes pathological remodeling (reverse remodeling) might aid in identifying therapies, particularly in aging populations in which RV failure is significant. Our objective was to determine if the aged RV can undergo reverse remodeling following the resolution of pathological afterload by pulmonary hypertension (PH). We exposed male and female aged (18-21 months) C57BL/6 mice to hypobaric hypoxia (HH) for 4 weeks to model PH before returning the mice to normoxia for three (WK3RR) or six (WK6RR) weeks. HH stimulated RV hypertrophy and fibrosis which were attenuated with WK3RR and WK6RR. Activation of autophagy and anti-fibrotic pathways likely underlie morphological reverse remodeling. However, HH decreased RV systolic function as assessed by fractional area change (FAC) and stroke volume (SV) that were not rescued with normoxia re-exposure. The aged RV can undergo morphological reverse remodeling following the removal of pathological load; however, RV function does not improve. Further investigation into the mechanisms of reverse remodeling may identify potential drug therapies for maladaptive RV remodeling with aging.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70422"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose ingestion increases passive absorption of a nutrient-sized solute, mannitol, in healthy young adults. 在健康的年轻人中，葡萄糖的摄入增加了营养大小的溶质甘露醇的被动吸收。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70427

G Patrick Lambert, Caroline Jachino, Liam Murphy, Katherine Krueger

{"title":"Glucose ingestion increases passive absorption of a nutrient-sized solute, mannitol, in healthy young adults.","authors":"G Patrick Lambert, Caroline Jachino, Liam Murphy, Katherine Krueger","doi":"10.14814/phy2.70427","DOIUrl":"10.14814/phy2.70427","url":null,"abstract":"Active glucose absorption increases passive, paracellular absorption of small solutes. Absorption of larger molecules by this mechanism has not been verified in humans under physiological conditions. The purpose of this study was to determine if ingestion of a glucose solution enhances absorption of mannitol in humans. Mannitol (182 Da) is a non-metabolizable molecule believed to be absorbed only via the paracellular route. Its urinary excretion therefore may serve as an index for paracellular absorption of similar-sized solutes, such as glucose (180 Da) and amino acids (average 138 Da). Eight healthy individuals (five females, three males; mean age = 22 +/- 1 yrs) ingested a 4% glucose/0.2% mannitol solution or a 4% fructose/0.2% mannitol solution using a randomized, balanced design. Urine was collected for 5 h and mannitol excretion determined. Ingestion of the glucose solution increased (p < 0.05) mannitol excretion (0.52 +/-0.27 g) compared to the fructose solution (0.39 +/-0.13 g), a 33% increase. These results indicate glucose promotes passive absorption of nutrient-sized solutes, likely via the paracellular route. This may explain how humans can absorb high amounts of glucose when maximal active transport is exceeded. Furthermore, other nutrients such as amino acids may utilize this route, thereby enhancing absorption.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70427"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study. 急性高多酚、高纤维膳食加或不加有氧运动对中老年人代谢的影响：一项初步研究。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70312

L J Ater, E K Plantz, T D Manning, J D Akers, E S Edwards, S P Kurti

{"title":"The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study.","authors":"L J Ater, E K Plantz, T D Manning, J D Akers, E S Edwards, S P Kurti","doi":"10.14814/phy2.70312","DOIUrl":"10.14814/phy2.70312","url":null,"abstract":"A high fat, high carbohydrate (HFHC) meal can induce adverse triglyceride (TRG), glucose, and metabolic load index (MLI; TRG + glucose) in middle-aged and older adults. A bout of exercise (EX) or an acute meal may attenuate these postprandial responses. This study aimed to determine whether a high polyphenol, high fiber meal with and without EX could reduce postprandial TRG, glucose, and MLI in this population. In a randomized crossover design, 10 healthy adults (56.9 ± 6.9 years, 6F, 4M) completed four conditions: (1) traditional HFHC, (2) T-HFHC + EX, (3) HFHC meal with polyphenols and fiber (P-HFHC), (4) a P-HFHC + EX. Each participant consumed 12 kcals/kg body mass. The P-HFHC was made with plant-based ingredients to match the macronutrient composition of the T-HFHC. EX, performed 30 min post-meal, expended 25% of kcals consumed. Blood TRG and glucose were measured for 6 h post-meal, and MLI was calculated. There was a significant time*condition interaction for TRG (p = 0.038), glucose (p = 0.001), and MLI (p = 0.026). The P-HFHC condition had lower TRGs at 4 and 5 h (p = 0.031, p = 0.050). These findings suggest that a minimally processed meal or EX may reduce CVD risk in middle-aged and older adults.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70312"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia? 高血压是否会加剧运动后肌肉缺血时动态运动引起的年龄相关性过度降压反应？

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70365

Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Kenichi Suijo, Masaki Mizuno, Norio Hotta

{"title":"Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia?","authors":"Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Kenichi Suijo, Masaki Mizuno, Norio Hotta","doi":"10.14814/phy2.70365","DOIUrl":"10.14814/phy2.70365","url":null,"abstract":"Hypertension is known to augment exercise blood pressure (BP). Aging also potentiates BP response to ischemic dynamic exercise. However, whether hypertension further enhances aging-induced augmented BP response to ischemic dynamic exercise has not yet been investigated. Therefore, we aimed to test the hypothesis that hypertension exacerbates the pressor response to ischemic dynamic exercise in older adults. The participants were classified into the following two groups: nonhypertensive (NHT, n = 13, 60-80 years) and hypertensive (HT, n = 10, 61-78 years). We compared the BP responses to very light-intensity rhythmic handgrip exercise during post-isometric handgrip exercise muscle ischemia (PEMI) simulated as ischemic dynamic exercise between the HT and NHT groups. Both systolic BP (SBP) and diastolic BP (DBP) responses to the rhythmic handgrip exercise during PEMI in the HT group (∆SBP: 48 ± 18 mmHg and ∆DBP: 28 ± 10 mmHg, p = 0.007) were significantly higher than those in the NHT group (∆SBP: 34 ± 17 mmHg and ∆DBP: 20 ± 6 mmHg, p = 0.003). Importantly, resting SBP was a significant independent determinant of DBP response to the rhythmic handgrip exercise during PEMI (β = 0.412, p = 0.047). These results suggest that hypertension further elevates the heightened BP response to ischemic dynamic exercise in older adults.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70365"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of body inclination on suprahyoid muscle activity during repetitive voluntary swallowing: A randomized crossover study. 反复自主吞咽时身体倾斜对舌骨上肌活动的影响：一项随机交叉研究。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70426

Yumiko Kubo, Hideyuki Fukami

{"title":"Effect of body inclination on suprahyoid muscle activity during repetitive voluntary swallowing: A randomized crossover study.","authors":"Yumiko Kubo, Hideyuki Fukami","doi":"10.14814/phy2.70426","DOIUrl":"https://doi.org/10.14814/phy2.70426","url":null,"abstract":"This study examined how body inclination affects swallowing dynamics by analyzing suprahyoid muscle activity during repetitive voluntary swallowing with minimal pharyngeal sensory stimulation. Fourteen healthy female volunteers participated. Surface electromyography (EMG) was recorded from suprahyoid muscles during repetitive voluntary swallowing with slow infusion (0.2 mL/min) of 0.3 M NaCl solution. Measurements were taken at four angles: upright (90°), reclined at 60°, reclined at 30°, and supine (0°). Body inclination significantly affected swallowing intervals (SI) and EMG burst duration. The upright position showed significantly shorter SIs compared to 60° reclined and supine positions. The 30° reclined position also demonstrated shorter swallowing intervals than supine. EMG burst duration was significantly shorter in the upright position compared to all reclined positions. No significant differences were observed in EMG amplitude across different angles. This study demonstrates that greater reclining angles (60° or more) make voluntary repetitive swallowing more difficult. Findings suggest that dysphagia rehabilitation should be conducted at positions elevated at least 30° from supine for optimal outcomes.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70426"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0