Physiological Reports最新文献_第3页

Corticomuscular and intermuscular coherence during evidence accumulation in sensorimotor decision-making.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70237

Yvonne F Visser, W Pieter Medendorp, Luc P J Selen

{"title":"Corticomuscular and intermuscular coherence during evidence accumulation in sensorimotor decision-making.","authors":"Yvonne F Visser, W Pieter Medendorp, Luc P J Selen","doi":"10.14814/phy2.70237","DOIUrl":"10.14814/phy2.70237","url":null,"abstract":"Evidence accumulation processes during decision-making are thought to continuously feed into the motor system, preparing multiple competing motor plans, of which one is executed when the evidence is complete. Previously, the state of this accumulation process has been studied by reading out the preparatory state of the motor system with evoked responses, once per trial. In this study, we aim to continuously track the sensorimotor decision during the trial using corticomuscular (CMC) and intermuscular coherence (IMC). We recorded EEG and EMG of healthy young adults (n = 34) who viewed random dot motion stimuli, with varying strengths across trials, and indicated their perceived motion direction by reaching towards one of two targets, requiring either flexion or extension of the elbow. Coherence was computed in the beta band. After stimulus presentation, both CMC and IMC show an initial phasic pattern, which is followed by sustained coherence patterns at a level that depends on stimulus strength for CMC. Prior to reach onset, the CMC for different stimulus strengths had a tendency to settle at similar levels. This tendency tentatively marks a stimulus-independent decision bound. We conclude that CMC, and to a lesser extent IMC, track the evidence accumulation process on a single trial.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70237"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70281

Guilherme F Speretta, Gaia Giuriato, Gianluigi Dorelli, Chiara Barbi, Anna Pedrinolla, Massimo Venturelli

{"title":"Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.","authors":"Guilherme F Speretta, Gaia Giuriato, Gianluigi Dorelli, Chiara Barbi, Anna Pedrinolla, Massimo Venturelli","doi":"10.14814/phy2.70281","DOIUrl":"10.14814/phy2.70281","url":null,"abstract":"Vascular responsiveness due to passive leg movement (PLM) on the brain remains unknown. This study aimed to evaluate the effects of cold-induced sympathetic activation (CPT) on femoral and ipsilateral and contralateral carotid arteries' vascular responsiveness evoked by PLM. Thirteen participants (seven males and six females; age: 27.0 ± 2.3 years) undertook a randomized session in which PLM was performed on the right leg at rest and during CPT. Right femoral (fBF) and right (ipsilateral) and left (contralateral) carotid (cBF) blood flows were measured by ultrasounds, and heart hemodynamics were assessed via photoplethysmography and impedance cardiograph. Systolic arterial pressure (SAP) time series were used to infer sympathetic modulation to the vessels. Femoral (fVC) and carotid (cVC) vascular conductance (BF/MAP) were calculated. CPT evoked changes in PLM on cBF, fBF, and fVC (interaction and time effect). cBF peak and cBF and cVC area under the curve were higher in the contralateral carotid in the two interventions. Low-frequency power of SAP was higher in PLM-CPT than in PLM; all p < 0.05. These results suggest that the CPT-induced increases in sympathetic modulation attenuate the vascular responsiveness in the femoral, but not the carotid, arteries. Also, the contralateral carotid increased blood flow during PLM, regardless of the CPT.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70281"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of myogenic vasoconstriction in human bone vasculature.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70278

Adina E Draghici, Matthew R Ely, Jason W Hamner

{"title":"Evidence of myogenic vasoconstriction in human bone vasculature.","authors":"Adina E Draghici, Matthew R Ely, Jason W Hamner","doi":"10.14814/phy2.70278","DOIUrl":"10.14814/phy2.70278","url":null,"abstract":"Despite the critical importance of blood flow for bone, mechanisms regulating bone vasculature are poorly understood. Myogenic vasoconstriction is an important regulatory mechanism that is engaged in most daily activities, but our understanding primarily derives from animal work and/or other vascular beds. In young healthy adults, we employed two levels of leg dependency to engage myogenic vasoconstriction. We measured tibial blood content via near-infrared spectroscopy (total hemoglobin, ΔtHb) and contrasted it to whole leg flow via popliteal blood flow velocity (LBV) via Doppler ultrasound. Myogenic vasoconstriction was engaged by lowering the leg below heart level (supine to upright to dependent), resulting in increased leg perfusion pressure as assessed by brachial mean pressure adjusted for the hydrostatic pressure from the heart to the tibia. Increased leg perfusion pressure in both positions (Δ30.1 ± 1.36 and Δ42.1 ± 1.16 mmHg; p < 0.01) was accompanied by graded declines in LBV (Δ-1.88 ± 0.21 and Δ-2.98 ± 0.27 cm/(s*beat); p < 0.01), indicating whole limb myogenic vasoconstriction. Tibial hemoglobin content did not change (ΔtHb: -0.28 ± 1.76 and 1.26 ± 2.33 μM; p > 0.5), indicating myogenic vasoconstriction was evident, but of lower magnitude compared to the whole leg. These results indicate that myogenic vasoconstriction plays an active role in regulating the tibial vasculature, but with a less robust response compared to the whole leg.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70278"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rest-to-work and work-to-rest transients of interstitial PO₂ in spinotrapezius muscle of young and old male rats.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70260

Aleksander S Golub, William H Nugent, Roland N Pittman, Bjorn K Song

{"title":"Rest-to-work and work-to-rest transients of interstitial PO2 in spinotrapezius muscle of young and old male rats.","authors":"Aleksander S Golub, William H Nugent, Roland N Pittman, Bjorn K Song","doi":"10.14814/phy2.70260","DOIUrl":"10.14814/phy2.70260","url":null,"abstract":"Muscle function declines with age. Since the primary energy source for contraction is aerobic, this study investigated age-related changes in muscle oxygenation dynamics to: characterize PO2 transients during rest-work transitions, identify age-specific differences in oxygen delivery/utilization balance, and examine the relationship between interstitial and arterial oxygen tension (PO2). Interstitial PO2 was measured with a high-resolution stroboscopic phosphorescence quenching technique to map intra-contractile dynamics during changes in muscle activity-rest-to-work (RtW) and work-to-rest (WtR) in rats aged three (young) and 23 (old) months. RtW (τw) and WtR (τr) PO2 transitions had lag periods and mono-exponential time constants. In young muscles, lag was 4 s, τw = 9.0 ± 3.7 s, and τr = 15.4 ± 3.9 s. For old, lag was also 4 s with increases to τw = 15.9 ± 3.5 s and τr = 41.4 ± 8.3 s. Resting PO2's were higher for young than for old (66.7 ± 13.7 vs. 60.2 ± 13.0 mmHg; p < 0.05). Work reduced PO2 with a greater effect on old (42.5 ± 14.0 vs. 28.3 ± 16.5 mmHg; p < 0.05). Intra-contractile measurements revealed a spike in PO2 (11 mmHg amplitude for >200 ms), which was absent in old. Further, sustained exercise in young showed a rising trend in PO2, while old remained at nadir. The missing PO2 spike in aged muscle contributes to reduced PO2 during work and may explain age-related loss of endurance.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70260"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural analysis of mitochondrial morphology and in the human rhabdosphincter: Insights into urinary incontinence.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70265

Shinro Hata, Mayuka Shinohara, Hiromitsu Mimata, Toshitaka Shin

{"title":"Ultrastructural analysis of mitochondrial morphology and in the human rhabdosphincter: Insights into urinary incontinence.","authors":"Shinro Hata, Mayuka Shinohara, Hiromitsu Mimata, Toshitaka Shin","doi":"10.14814/phy2.70265","DOIUrl":"10.14814/phy2.70265","url":null,"abstract":"Urinary incontinence increases with age, reducing the elderly quality of life. Understanding its mechanisms and developing treatments are urgent tasks. While healthy striated muscle maintains homeostasis through mitophagy, aging is thought to reduce autophagy activity. This study aimed to detect abnormal mitochondrial accumulation in the rhabdosphincter using transmission electron microscopy (TEM). We collected the rhabdosphincter samples from seven patients undergoing cystectomy and used the rectus abdominis as controls. Both tissues were examined with Hematoxylin and eosin (HE) staining and TEM. ImageJ software was used to measure the mitochondrial area, perimeter, and luminance. HE staining revealed that the rhabdosphincter had fewer muscle fibers and more stromal tissue than the rectus abdominis. TEM images showed more gaps in muscle bundles and signs of mitochondrial damage, vacuolation, and swelling in the rhabdosphincter. Quantitative analysis revealed a larger average mitochondrial area (0.21 μm2 vs. 0.063 μm2, p < 0.01), longer perimeter (1.83 μm vs. 0.94 μm, p < 0.01) and higher luminance (156.6 vs. 90.2, p < 0.01) than those of the rectus abdominis. The rhabdosphincter of elderly individuals showed significant mitochondrial morphological abnormalities, with increased swelling and vacuolation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70265"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ML-UrineQuant: A machine learning program for identifying and quantifying mouse urine on absorbent paper.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70243

Warren G Hill, Bryce MacIver, Gary A Churchill, Mariana G DeOliveira, Mark L Zeidel, Marcelo Cicconet

引用次数: 0

Fasting plasma C-peptide correlates with body mass index, hsCRP, apolipoprotein B, and other atherogenic lipids in healthy individuals.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70282

Per A Whiss, Evangelia Baldimtsi, Jeanette Wahlberg

{"title":"Fasting plasma C-peptide correlates with body mass index, hsCRP, apolipoprotein B, and other atherogenic lipids in healthy individuals.","authors":"Per A Whiss, Evangelia Baldimtsi, Jeanette Wahlberg","doi":"10.14814/phy2.70282","DOIUrl":"10.14814/phy2.70282","url":null,"abstract":"C-peptide has a complex role in human physiology, but its effects are not fully understood. Studies have shown a protective impact against diabetic complications, but also that C-peptide levels associate with cardiovascular events. Among the many applications to assess cardiovascular risk, circulating lipids are widely used, and one of the strongest biomarkers is apolipoprotein B. The aim of this investigation was to study the association of C-peptide with markers of metabolic, inflammatory, or cardiovascular alterations in a limited group of healthy individuals. Body mass index (BMI), lipids, and other plasma markers were studied in 28 consecutive healthy individuals within the age of 30-50 years. The results showed significant positive correlations between C-peptide and BMI (r = 0.498; p = 0.007); hsCRP (r = 0.530; p = 0.004); triglycerides (r = 0.530; p = 0.005); cholesterol (r = 0.507; p = 0.006), LDL-cholesterol (r = 0.550; p = 0.002), LDL/HDL ratio (r = 0.460; p = 0.014); apoB (r = 0.622; p < 0.001), apoB/apoA1 ratio (r = 0.563; p = 0.002); and non-HDL cholesterol (r = 0.566; p = 0.002). According to BMI values, 16 of the 28 individuals were overweight (BMI >25.0 kg/m2). If overweight individuals were excluded, C-peptide did only correlate with apoB (r = 0.636; p = 0.026). To conclude, C-peptide within normal levels associate with BMI and atherogenic lipids in healthy individuals, and apoB associate with C-peptide even at normal weight. These results suggest that C-peptide can be an early additional cardiovascular risk marker.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70282"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of popliteal artery flow-mediated dilation in the seated position.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70252

Taskina Akhter, Patrick B Wilson, J David Branch, Leryn J Reynolds

{"title":"Reliability of popliteal artery flow-mediated dilation in the seated position.","authors":"Taskina Akhter, Patrick B Wilson, J David Branch, Leryn J Reynolds","doi":"10.14814/phy2.70252","DOIUrl":"10.14814/phy2.70252","url":null,"abstract":"Flow-mediated dilation (FMD), a noninvasive measure of endothelial function, is commonly measured in the popliteal artery in the supine and upright body positions. However, reliability studies of the measurement in these positions are not well studied. This study aimed to examine the trial-retrial and visit-to-visit reliability of popliteal artery FMD in the seated position. Popliteal artery FMD was measured in 20 healthy adults across two visits in the seated and prone positions to assess visit-to-visit reliability. Two measurements were taken for each body position at each visit to assess trial-retrial reliability. %FMD was calculated as the percent change from baseline diameter to peak diameter. The reliability of FMD was assessed via the intraclass correlation coefficient (ICC). Popliteal artery %FMD shows moderate-to-good reliability in the seated position (ICC: 0.67-0.89) and poor-to-moderate reliability in the prone position (ICC: 0.25-0.74) within and between visits. There were no significant differences in baseline diameter or minimum diameter between body positions, visits, or trials (p > 0.05). %FMD and peak diameter following cuff deflation demonstrated no significant difference between body positions (p > 0.05). Popliteal artery FMD demonstrates good reliability in the seated position, supporting the development of a standardized measurement protocol.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70252"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fasciculation distribution in a healthy population assessed with diffusion tensor imaging. 利用弥散张量成像技术评估健康人群的筋束分布。

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70247

Linda Heskamp, Lara Schlaffke, Johannes Forsting, Boudewijn T H M Sleutjes, H Stephan Goedee, Martijn Froeling

{"title":"Fasciculation distribution in a healthy population assessed with diffusion tensor imaging.","authors":"Linda Heskamp, Lara Schlaffke, Johannes Forsting, Boudewijn T H M Sleutjes, H Stephan Goedee, Martijn Froeling","doi":"10.14814/phy2.70247","DOIUrl":"10.14814/phy2.70247","url":null,"abstract":"Fasciculations, a hallmark of motor neuron diseases, also occur in healthy individuals, highlighting the need to understand fasciculation intensity and distribution. Motor unit MRI (MUMRI) can assess fasciculations in large volumes but is not widely applied. We hypothesize that a more common MRI technique, diffusion tensor imaging (DTI), can also detect fasciculation when correcting for low signal-to-noise ratios and signal variability. We first systematically compared MUMRI and DTI in upper leg muscles of healthy subjects (n = 5). Secondly, we retrospectively determined fasciculation intensity and distribution in lower extremity muscles of 30 healthy subjects using DTI (n = 30). DTI and MUMRI had comparable sensitivity (75%) and precision (80%) to expert reviews. In our healthy cohort, fasciculations were more prevalent in the lower legs than upper legs (13.9 ± 11.5% vs. 9.8 ± 6.3%, p = 0.011), particularly in the soleus (9.3 ± 8.1%). This effect persisted after normalizing for muscle volume (7.2 ± 5.1%/dm3 vs. 2.9 ± 1.8%/dm3, p < 0.001). Lower leg fasciculations were larger compared to upper leg fasciculations (0.81 ± 0.31 cm3 vs. 0.54 ± 0.15 cm3, p < 0.001). Longitudinal analysis showed consistent fasciculation distribution over 8 months (n = 13, ICC = 0.803). In conclusion, muscle DTI detects fasciculations in all lower extremity muscles, enabling retrospective analysis of existing datasets and reducing the need for prospective MUMRI studies if muscle DTI is already acquired.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70247"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70277

Muneeb Iqbal, Edward Bliss, Eliza J Whiteside, Ben Hoffman, Dean E Mills

{"title":"The effects of volitional hyperpnea on biomarkers of respiratory muscle damage in healthy young men.","authors":"Muneeb Iqbal, Edward Bliss, Eliza J Whiteside, Ben Hoffman, Dean E Mills","doi":"10.14814/phy2.70277","DOIUrl":"10.14814/phy2.70277","url":null,"abstract":"High-intensity exercise hyperpnea places substantial demands upon the respiratory muscles, but whether this causes respiratory muscle damage is unknown. We investigated respiratory muscle damage following volitional hyperpnea (equivalent to 85% of participants maximum minute ventilation produced during a maximal incremental cycling test) using a skeletal muscle damage biomarker panel. Eight healthy men (33 + 2 years) underwent 10-min trials of volitional hyperpnea and rest (control) two weeks apart. Serum was collected before and at 1, 24, and 48 h after both volitional hyperpnea and control trials. Creatine kinase muscle-type (CKM), fast skeletal troponin I (sTnI) and slow sTnI were measured using enzyme-linked immunosorbent assay. Two-way analysis of variance revealed time × trial interaction effects for slow sTnI (p = 0.018), but not for CKM (p = 0.072) and fast sTnI (p = 0.140). Slow sTnI was significantly higher at +24 h post volitional hyperpnea (p < 0.001) as compared to the same time point of the control trial. These results indicate that high-intensity exercise hyperpnea may induce a small amount of respiratory muscle damage as evidenced by the increases in slow sTnI. Future studies including more time points, different respiratory muscle exercise protocols, and examining the differences between sexes could provide additional insights into the utility of blood biomarkers for identifying respiratory muscle damage.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70277"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0