Physiological Reports最新文献_第4页

The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study. 急性高多酚、高纤维膳食加或不加有氧运动对中老年人代谢的影响：一项初步研究。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70312

L J Ater, E K Plantz, T D Manning, J D Akers, E S Edwards, S P Kurti

{"title":"The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study.","authors":"L J Ater, E K Plantz, T D Manning, J D Akers, E S Edwards, S P Kurti","doi":"10.14814/phy2.70312","DOIUrl":"10.14814/phy2.70312","url":null,"abstract":"A high fat, high carbohydrate (HFHC) meal can induce adverse triglyceride (TRG), glucose, and metabolic load index (MLI; TRG + glucose) in middle-aged and older adults. A bout of exercise (EX) or an acute meal may attenuate these postprandial responses. This study aimed to determine whether a high polyphenol, high fiber meal with and without EX could reduce postprandial TRG, glucose, and MLI in this population. In a randomized crossover design, 10 healthy adults (56.9 ± 6.9 years, 6F, 4M) completed four conditions: (1) traditional HFHC, (2) T-HFHC + EX, (3) HFHC meal with polyphenols and fiber (P-HFHC), (4) a P-HFHC + EX. Each participant consumed 12 kcals/kg body mass. The P-HFHC was made with plant-based ingredients to match the macronutrient composition of the T-HFHC. EX, performed 30 min post-meal, expended 25% of kcals consumed. Blood TRG and glucose were measured for 6 h post-meal, and MLI was calculated. There was a significant time*condition interaction for TRG (p = 0.038), glucose (p = 0.001), and MLI (p = 0.026). The P-HFHC condition had lower TRGs at 4 and 5 h (p = 0.031, p = 0.050). These findings suggest that a minimally processed meal or EX may reduce CVD risk in middle-aged and older adults.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70312"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia? 高血压是否会加剧运动后肌肉缺血时动态运动引起的年龄相关性过度降压反应？

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70365

Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Kenichi Suijo, Masaki Mizuno, Norio Hotta

{"title":"Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia?","authors":"Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Kenichi Suijo, Masaki Mizuno, Norio Hotta","doi":"10.14814/phy2.70365","DOIUrl":"10.14814/phy2.70365","url":null,"abstract":"Hypertension is known to augment exercise blood pressure (BP). Aging also potentiates BP response to ischemic dynamic exercise. However, whether hypertension further enhances aging-induced augmented BP response to ischemic dynamic exercise has not yet been investigated. Therefore, we aimed to test the hypothesis that hypertension exacerbates the pressor response to ischemic dynamic exercise in older adults. The participants were classified into the following two groups: nonhypertensive (NHT, n = 13, 60-80 years) and hypertensive (HT, n = 10, 61-78 years). We compared the BP responses to very light-intensity rhythmic handgrip exercise during post-isometric handgrip exercise muscle ischemia (PEMI) simulated as ischemic dynamic exercise between the HT and NHT groups. Both systolic BP (SBP) and diastolic BP (DBP) responses to the rhythmic handgrip exercise during PEMI in the HT group (∆SBP: 48 ± 18 mmHg and ∆DBP: 28 ± 10 mmHg, p = 0.007) were significantly higher than those in the NHT group (∆SBP: 34 ± 17 mmHg and ∆DBP: 20 ± 6 mmHg, p = 0.003). Importantly, resting SBP was a significant independent determinant of DBP response to the rhythmic handgrip exercise during PEMI (β = 0.412, p = 0.047). These results suggest that hypertension further elevates the heightened BP response to ischemic dynamic exercise in older adults.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70365"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of body inclination on suprahyoid muscle activity during repetitive voluntary swallowing: A randomized crossover study. 反复自主吞咽时身体倾斜对舌骨上肌活动的影响：一项随机交叉研究。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70426

Yumiko Kubo, Hideyuki Fukami

{"title":"Effect of body inclination on suprahyoid muscle activity during repetitive voluntary swallowing: A randomized crossover study.","authors":"Yumiko Kubo, Hideyuki Fukami","doi":"10.14814/phy2.70426","DOIUrl":"10.14814/phy2.70426","url":null,"abstract":"This study examined how body inclination affects swallowing dynamics by analyzing suprahyoid muscle activity during repetitive voluntary swallowing with minimal pharyngeal sensory stimulation. Fourteen healthy female volunteers participated. Surface electromyography (EMG) was recorded from suprahyoid muscles during repetitive voluntary swallowing with slow infusion (0.2 mL/min) of 0.3 M NaCl solution. Measurements were taken at four angles: upright (90°), reclined at 60°, reclined at 30°, and supine (0°). Body inclination significantly affected swallowing intervals (SI) and EMG burst duration. The upright position showed significantly shorter SIs compared to 60° reclined and supine positions. The 30° reclined position also demonstrated shorter swallowing intervals than supine. EMG burst duration was significantly shorter in the upright position compared to all reclined positions. No significant differences were observed in EMG amplitude across different angles. This study demonstrates that greater reclining angles (60° or more) make voluntary repetitive swallowing more difficult. Findings suggest that dysphagia rehabilitation should be conducted at positions elevated at least 30° from supine for optimal outcomes.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70426"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pristine unused pulmonary surfactant isolated from human amniotic fluid forms highly condensed interfacial films. 从人羊水中分离的原始未使用的肺表面活性剂形成高度凝聚的界面膜。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70403

Juan Carlos Castillo-Sánchez, Ainhoa Collada, Emma Batllori-Badia, Alberto Galindo, Antonio Cruz, Jesús Pérez-Gil

{"title":"The pristine unused pulmonary surfactant isolated from human amniotic fluid forms highly condensed interfacial films.","authors":"Juan Carlos Castillo-Sánchez, Ainhoa Collada, Emma Batllori-Badia, Alberto Galindo, Antonio Cruz, Jesús Pérez-Gil","doi":"10.14814/phy2.70403","DOIUrl":"https://doi.org/10.14814/phy2.70403","url":null,"abstract":"Pulmonary surfactant is a lipid/protein complex that coats the alveolar air-liquid interface to minimize surface tension facilitating breathing mechanics. Native surfactant (NS) is typically obtained from lavages of animal lungs, where it has gone through structural alterations as a result of exposure to respiratory dynamics and highly oxidative environments. We have studied here the structure of interfacial films formed by human amniotic fluid surfactant (AFS), thought to maintain the structural and functional features of a fully operative still non-used surfactant, as it has not been subjected to breathing dynamics yet. The results show that AFS adsorbs better at the interface, to form films supporting higher compression rates, than NS upon spreading at comparable concentrations and amounts. Films formed by AFS exhibit condensed regions excluding fluorescently labeled lipids from the mere adsorption, while films formed by NS only showed segregation of ordered-like domains once subjected to compression-expansion dynamics. Finally, AFS films were consistent with the presence of solid-like highly ordered phases, while NS consisted under comparable conditions of a coexistence of liquid-disordered/liquid-ordered fluid phases. This indicates that operative surfactant films formed by freshly secreted surfactant could be much more condensed than previously supposed, likely providing maximal stability under breathing mechanics.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70403"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parenclitic network mapping predicts survival in critically ill patients with sepsis. 临床网络映射预测脓毒症危重患者的生存。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70407

Emily Ito, Tope Oyelade, Matthew Wikner, Jinyuan Liu, Watjana Lilaonitkul, Ali R Mani

{"title":"Parenclitic network mapping predicts survival in critically ill patients with sepsis.","authors":"Emily Ito, Tope Oyelade, Matthew Wikner, Jinyuan Liu, Watjana Lilaonitkul, Ali R Mani","doi":"10.14814/phy2.70407","DOIUrl":"10.14814/phy2.70407","url":null,"abstract":"Sepsis is a complex disease involving multiple organ systems. A network physiology approach to sepsis may reveal collective system behaviors and intrinsic organ interactions. However, mapping functional connectivity for individual patients has been challenging due to the lack of analytical methods for evaluating physiological networks using routine clinical and laboratory data. This study explored the use of parenclitic network mapping to assess organ connectivity and predict sepsis outcomes based on routine laboratory data. Data from 162 sepsis patients meeting Sepsis-3 criteria were retrospectively analyzed from the MIMIC-III database. Fifteen physiological variables representing organ systems were used to construct organ network connectivity through correlation analysis. Correlation analysis identified 7 interactions linked to 30-day survival. Parenclitic network analysis was used to measure deviations in individual patients' correlations between organ systems from the reference physiological interactions observed in survivors. Parenclitic deviations in the pH-bicarbonate axis (hazard ratio = 2.081, p < 0.001) and pH-lactate axis (hazard ratio = 2.773, p = 0.024) significantly predicted 30-day mortality, independent of the Sequential Organ Failure Assessment (SOFA) score and ventilation status. This study highlights the potential of parenclitic network mapping to provide insights into sepsis pathophysiology and differences in organ system connectivity between survivors and non-survivors independent of sepsis severity and mechanical ventilation status.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70407"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative fluid therapy impairs lymphatic pump function in male rats. 围手术期液体治疗损害雄性大鼠淋巴泵功能。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70389

Rebecca C Harlow-Adamek, Reetu Singh, Randolph H Stewart, Cristine L Heaps, Glen A Laine, Charles S Cox, Ranjeet M Dongaonkar

{"title":"Perioperative fluid therapy impairs lymphatic pump function in male rats.","authors":"Rebecca C Harlow-Adamek, Reetu Singh, Randolph H Stewart, Cristine L Heaps, Glen A Laine, Charles S Cox, Ranjeet M Dongaonkar","doi":"10.14814/phy2.70389","DOIUrl":"10.14814/phy2.70389","url":null,"abstract":"Because of its life-saving benefits, perioperative IV fluid therapy remains a cornerstone of medical treatment. However, it also induces sustained edemagenic stress. The resulting persistent interstitial edema-excessive fluid accumulation in the interstitium-significantly delays recovery and worsens patient outcomes. Therefore, to gain a detailed understanding of the lymphatic functional consequences of perioperative fluid therapy, this study aimed to test the hypothesis that perioperative IV fluid therapy compromises lymphatic pump function within 3 days after major surgery. Following a midline laparotomy, animals received IV fluid therapy over 48 h during recovery (FLTP). Three days post-surgery, mesenteric lymphatic vessels from FLTP and sham surgery (CTRL) animals were isolated, and lymphatic pump function was assessed in vitro. The transmural pressure-pump flow and circumferential length-wall tension relationships of FLTP vessels were altered-contraction frequency and normalized pump flow and active and passive wall tensions were significantly lower than CTRL. In vessels from another group of animals with surgically produced mesenteric venous hypertension to induce sustained edemagenic stress, only the pressure-pump flow relationship was altered similarly to FLTP. These results demonstrate the detrimental effects of perioperative fluid therapy on lymphatic pumping, which is essential for restoring interstitial fluid pressure and resolving edema and inflammation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70389"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and age differences in the association between heart rate variability and cardiac chronotropy: A replication-extension study. 心率变异性和心脏慢变性之间的性别和年龄差异：一项复制扩展研究。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70399

Luca Carnevali, Darcianne K Watanabe, Margherita Barbetti, Suzi Hong, DeWayne P Williams, Jordan Kohn, Julian Koenig, Julian F Thayer

{"title":"Sex and age differences in the association between heart rate variability and cardiac chronotropy: A replication-extension study.","authors":"Luca Carnevali, Darcianne K Watanabe, Margherita Barbetti, Suzi Hong, DeWayne P Williams, Jordan Kohn, Julian Koenig, Julian F Thayer","doi":"10.14814/phy2.70399","DOIUrl":"10.14814/phy2.70399","url":null,"abstract":"Using heart rate variability (vmHRV) as a proxy of cardiac vagal modulation, previous studies have hinted at sex differences in the vagal control of cardiac chronotropy in young adults, but little is known in older individuals. The current study aimed at investigating for the first time the moderating role of both sex and age in the relationship between vmHRV and cardiac chronotropy in younger (n = 106, mean age: 19.9 (3.5) years) and older (n = 109, mean age: 72.8 (2.6) years) individuals. Further, we explored the effects of hormone replacement therapy on such association in a sub-sample of post-menopausal women (n = 17). Resting measures of the average inter-beat interval (IBI, as index of cardiac chronotropy) and vmHRV were collected. The results indicate (i) stronger associations between vmHRV and IBI in young adults and post-menopausal women compared to age-matched men, (ii) a weaker or no association in older women and men, respectively, and (iii) no effects of hormone replacement therapy in post-menopausal women. This study provides evidence of sex and age differences in the association between vmHRV and cardiac chronotropy, offering novel insight into vagal mechanisms of cardiac chronotropic control that may inform our understanding of sex- and age-related vulnerability to negative health outcomes.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70399"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin blood flow and skin temperature 24 h after induced muscle damage. 肌肉损伤24 h后皮肤血流量和皮肤温度。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70410

Clara Carrión-González, Andrea Martínez-Santarrufina, Carlos Libio Escrivá-Estellés, Lukas Verderber, Inmaculada Aparicio-Aparicio, Jose Ignacio Priego-Quesada

{"title":"Skin blood flow and skin temperature 24 h after induced muscle damage.","authors":"Clara Carrión-González, Andrea Martínez-Santarrufina, Carlos Libio Escrivá-Estellés, Lukas Verderber, Inmaculada Aparicio-Aparicio, Jose Ignacio Priego-Quesada","doi":"10.14814/phy2.70410","DOIUrl":"10.14814/phy2.70410","url":null,"abstract":"Infrared thermography is a noninvasive tool to monitor muscle damage, though its effectiveness is debated, as some studies report no skin temperature changes 24-48 h post-damage. These findings are often attributed to skin blood flow, but there is a lack of studies assessing this outcome. This study aimed to assess baseline skin temperature and skin blood flow responses 24 h after an induced quadriceps damage protocol and to establish a possible relationship between both variables. The thigh skin temperature and skin blood flow, pain perception, serum creatine kinase, and height of countermovement jump were measured in 15 physically active adults over 4 days, on two consecutive days per week. The induced muscle damage protocol, based on 100 drop jumps, was performed on the third day. Higher serum creatine kinase and pain perception (p < 0.01, ES > 1.20) were found 24 h after muscle damage induction. Thigh skin temperature and skin blood flow were unaffected by the muscle damage protocol, and a moderate correlation was observed between both outcomes (r = 0.59). We conclude that muscle damage does not alter skin blood flow 24 h after the induction, and therefore, this also had no consequences on skin temperature.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 11","pages":"e70410"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review and meta-analysis of the effect of exercise training on asprosin in randomized controlled trials. 随机对照试验中运动训练对肾上腺素影响的系统回顾和荟萃分析。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70392

Mohammad Rahman Rahimi, Michael E Symonds, Hassan Faraji, Hadi Golpasandi

{"title":"Systematic review and meta-analysis of the effect of exercise training on asprosin in randomized controlled trials.","authors":"Mohammad Rahman Rahimi, Michael E Symonds, Hassan Faraji, Hadi Golpasandi","doi":"10.14814/phy2.70392","DOIUrl":"10.14814/phy2.70392","url":null,"abstract":"Asprosin, a protein that enhances insulin resistance by stimulating hepatic glucose secretion, is linked to obesity, metabolic disorders, and cardiovascular diseases. This systematic review and meta-analysis investigate the influence of exercise training (ET) on circulating concentrations of asprosin. A systematic search of PubMed, Web of Science, and Google Scholar databases was conducted for all randomized controlled clinical trials from January 2016 to November 2024. A total of 431 relevant articles were retrieved and screened according to the study population, intervention method, and study type, resulting in the selection of 14 articles for the meta-analysis. All statistical results were analyzed using Comprehensive Meta-Analysis Software version 2 (CMA2). The overall effect size, using Hedges' g, based on the random effects model for asprosin with ET, was -1.70 (95% CI -2.17 to -1.23, p = 0.0001). A decrease in asprosin concentration was observed with all types of ET including aerobic training (AT, H = -1.71, p = 0.0001), high-intensity interval training (HIIT, H = -1.81, p = 0.001), and resistance training (RT, H = -1.62, p = 0.0001). Furthermore, subgroup analysis showed differences in asprosin based on body mass index (Q-value = 11.09, df = 2, p = 0.004) and health status of the subjects (Q-value = 12.64, df = 2, p = 0.002); however, there were no differences based on sex (p = 0.67), types (p = 0.96), and duration (p = 0.34) of training. Our findings suggest that ET is associated with a decrease in circulating asprosin that could have a beneficial effect in preventing metabolic disease that is enhanced with obesity. Systematic review registration PROSPERO: CRD42023468813.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70392"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N95 masks increase brain blood velocity and parasympathetic outflow, yet worsen orthostatic symptoms in a healthy cohort. 在健康队列中，N95掩盖了脑血流速度和副交感神经流出的增加，但加重了直立性症状。

IF 2.2

Physiological Reports Pub Date : 2025-06-01 DOI: 10.14814/phy2.70402

Tania J Pereira, Heather Edgell

{"title":"N95 masks increase brain blood velocity and parasympathetic outflow, yet worsen orthostatic symptoms in a healthy cohort.","authors":"Tania J Pereira, Heather Edgell","doi":"10.14814/phy2.70402","DOIUrl":"https://doi.org/10.14814/phy2.70402","url":null,"abstract":"Mask wearing became commonplace in everyday life during the COVID-19 pandemic and masks are frequently used in certain professions. Masks can increase end-tidal CO2 and the cerebrovasculature is known to vasodilate in response to hypercapnia. Orthostatic intolerance (OI) is the inability to tolerate postural transitions due to the displacement of blood volume away from the cerebral circulation, and we hypothesized that wearing a mask would improve OI symptoms by increasing brain blood flow. Young, healthy participants (n = 27) completed 10 min of 70° head-up tilt while wearing/not wearing an N95 mask (randomized), while hemodynamics and blood velocity within the middle cerebral artery (MCAv) were measured. Systolic, diastolic, and mean blood pressure and mean and diastolic MCAv decreased during tilt in both conditions (all p < 0.05; Table 1). Systolic MCAV was elevated while wearing a mask (p < 0.05). Some OI symptoms were exacerbated during the mask trial (all p < 0.05) including the overall OI score (p = 0.002; Table 2). There appears to be a disconnect between the physiological response to mask wearing and OI symptoms, potentially indicating that there is a psychological component to mask wearing. While we have provided evidence that masking increases brain blood flow, the psychological effects may outweigh potential benefits to the cerebral circulation.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 12","pages":"e70402"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0