Physiological Reports最新文献_第4页

Persistent endothelial dysfunction is associated with exercise intolerance in adults despite preserved myocardial work 3 years after SARS-CoV-2 infection. 持续的内皮功能障碍与成人运动不耐受相关，尽管在SARS-CoV-2感染后心肌工作保存了3年。

IF 2.1

Physiological Reports Pub Date : 2026-10-01 DOI: 10.14814/phy2.71103

Carla Cristina de Araújo Alves, Cássia da Luz Goulart, Luciana D'Ávila, Beatriz Helena Ernesto de Souza Silva, Igor Machado Alves, Brena Vitória Souza Aguiar, Claudia Conde, Ricardo Stein, Gerson Cipriano

{"title":"Persistent endothelial dysfunction is associated with exercise intolerance in adults despite preserved myocardial work 3 years after SARS-CoV-2 infection.","authors":"Carla Cristina de Araújo Alves, Cássia da Luz Goulart, Luciana D'Ávila, Beatriz Helena Ernesto de Souza Silva, Igor Machado Alves, Brena Vitória Souza Aguiar, Claudia Conde, Ricardo Stein, Gerson Cipriano","doi":"10.14814/phy2.71103","DOIUrl":"10.14814/phy2.71103","url":null,"abstract":"Long COVID is frequently associated with persistent exercise intolerance, although the relative contributions of peripheral vascular dysfunction and myocardial function remain unclear. We investigated whether persistent endothelial dysfunction and altered myocardial work (MW) contribute to exercise intolerance approximately 3 years after SARS-CoV-2 infection. This case-control study included adults with Long COVID (n = 10) and controls (n = 11) who underwent cardiopulmonary exercise testing (CPET), transthoracic echocardiography with global longitudinal strain (GLS) and MW analysis, and brachial artery flow-mediated dilation (FMD) with hyperemic shear assessment. Compared with controls, Long COVID participants exhibited lower peak V̇O2 (19.6 ± 2.5 vs. 24.3 ± 6.5 mL·kg-1·min-1, p = 0.04), percent-predicted peak V̇O2 (61.1 ± 8.3 vs. 77.0 ± 14.2%, p = 0.006), and V̇O2 at first ventilatory threshold (11.0 ± 1.4 vs. 13.7 ± 3.8 mL·kg-1·min-1, p = 0.04). Conventional echocardiographic parameters and MW indices did not differ between groups (all p > 0.05). In contrast, endothelial function was impaired in the Long COVID group, with lower FMD (p < 0.001), peak shear rate (p = 0.01), AUCSR (p = 0.04), and AUCmax (p = 0.001). FMD correlated positively with exercise capacity in the Long COVID group (peak V̇O2: r = 0.68, p = 0.03;percent-predicted peak V̇O2: r = 0.64, p = 0.04). In conclusion, 3 years after infection, Long COVID remains characterized by endothelial dysfunction and blunted hyperemic shear despite preserved MW, supporting a predominantly peripheral vascular basis for persistent exercise intolerance.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 19","pages":"e71103"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Handball participation and bone mineral accrual during growth: A 1-year longitudinal controlled study in young male athletes. 手球参与和成长过程中的骨矿物质积累：一项为期1年的年轻男性运动员纵向对照研究。

IF 2.1

Physiological Reports Pub Date : 2026-10-01 DOI: 10.14814/phy2.71133

Kawther Missawi, Maha Gasmi, Antonella Muscella, Tahir Volkan Aslan, Özgür Eken, Monira I Aldhahi, Mohamed Zouch

{"title":"Handball participation and bone mineral accrual during growth: A 1-year longitudinal controlled study in young male athletes.","authors":"Kawther Missawi, Maha Gasmi, Antonella Muscella, Tahir Volkan Aslan, Özgür Eken, Monira I Aldhahi, Mohamed Zouch","doi":"10.14814/phy2.71133","DOIUrl":"10.14814/phy2.71133","url":null,"abstract":"Multidirectional sports such as handball may provide beneficial mechanical stimuli, but longitudinal evidence in male children remains limited. This study examined one-year differences in bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) between male children engaged in regular handball practice and age-matched controls. This non-randomized longitudinal study included 72 healthy male children aged 10-12 years: handball group (HG, n = 36) and control group (CG, n = 36). Whole-body and regional bone outcomes were assessed using dual-energy X-ray absorptiometry. Between-group differences at follow-up were evaluated using ANCOVA, while longitudinal changes were examined using linear mixed-effects models. Handball players exhibited greater adjusted BMD at follow-up than controls, with the largest effect at the lumbar spine (adjusted mean difference = 0.034 g/cm2; 95% CI: 0.012-0.056; η2p = 0.14). Higher BMD was also observed at the whole body, total hip, lower limbs, femoral neck, and selected upper-limb sites. Adjusted BMC was greater at the lumbar spine, total hip, lower limbs, and selected radial regions. Increases in lean mass were positively associated with BMD gains at the whole body, hip, and femoral neck, whereas associations with BMC were more localized and those with BA were limited. These findings suggest that handball participation is associated with greater skeletal mineral accrual during growth.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 19","pages":"e71133"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ensemble-based label adjudication (EBLA): A method for validating continuous physiological measures against observer-dependent reference standards. 基于集合的标签判定（EBLA）：一种针对观察者依赖参考标准验证连续生理测量的方法。

IF 2.1

Physiological Reports Pub Date : 2026-10-01 DOI: 10.14814/phy2.71127

Guillermo Gutierrez, Fernando Papa

{"title":"Ensemble-based label adjudication (EBLA): A method for validating continuous physiological measures against observer-dependent reference standards.","authors":"Guillermo Gutierrez, Fernando Papa","doi":"10.14814/phy2.71127","DOIUrl":"10.14814/phy2.71127","url":null,"abstract":"Comparing a novel physiological measure against an observer-dependent reference standard creates uncertainty when results disagree because errors may arise from either method. We propose ensemble-based label adjudication (EBLA), a computational framework that uses agreement between two imperfect instruments to create a high-confidence training set for adjudicating discordant observations. EBLA was validated using the Wisconsin Breast Cancer Dataset (n = 569) with simulated label noise (10%-30%). Five classifiers were trained on concordant cases using stratified 5-fold cross-validation. In the primary 15%/15% noise scenario, majority-vote EBLA improved accuracy from 0.85 to 0.97, sensitivity from 0.87 to 0.98, and specificity from 0.84 to 0.97. Supermajority and unanimity thresholds did not improve accuracy and excluded 1.4% and 2.5% of cases. EBLA consistently outperformed Cleanlab across all noise conditions. Application to 281 paired Mechanical Ventilation Respiratory Distress Observation Scale (MV-RDOS) assessments and inspiratory effort measurements (PmusPTP) from 45 mechanically ventilated patients increased accuracy from 0.81 to 0.86, primarily by improving specificity from 0.88 to 0.94. EBLA provides a transparent, interpretable framework for sensitivity analysis when validating physiological measurements against imperfect observer-dependent reference standards.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 19","pages":"e71127"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between handgrip strength and symptoms of anxiety and depression among university students: A cross-sectional study. 大学生握力与焦虑、抑郁症状的关系：一项横断面研究

IF 2.1

Physiological Reports Pub Date : 2026-10-01 DOI: 10.14814/phy2.71143

Liyan Khadeeja, B K Manjunatha Goud, Rajani Dube, Subhranshu Sekhar Kar, Burhanuddin Murtaza Patanwala

{"title":"Association between handgrip strength and symptoms of anxiety and depression among university students: A cross-sectional study.","authors":"Liyan Khadeeja, B K Manjunatha Goud, Rajani Dube, Subhranshu Sekhar Kar, Burhanuddin Murtaza Patanwala","doi":"10.14814/phy2.71143","DOIUrl":"10.14814/phy2.71143","url":null,"abstract":"Handgrip strength is a simple and objective measure of muscle function, increasingly associated with physical and psychological health. However, data regarding its link to anxiety and depression in young adults remain limited. The aim of this study was to assess handgrip strength in healthy university students and examine its association with symptoms of anxiety and depression. This cross-sectional study included 216 undergraduate students (mean age: 20.6 ± 4.7 years). Handgrip strength of each participant was measured using a digital hand dynamometer. Symptoms of anxiety and depression were assessed using the GAD-7 (Generalized Anxiety Disorder-7) and the PHQ-9 (Patient Health Questionnaire-9), respectively. Pearson correlations and independent sample t-tests were used for statistical analysis. Handgrip strength showed a small but statistically significant negative correlation with PHQ-9 (left hand: r = -0.148, p = 0.030) and GAD-7 (left hand: r = -0.185, p = 0.006) scores. These associations were stronger in female participants. Anxiety and depression scores were strongly positively correlated (r = 0.705, p < 0.001). The results of this study indicate lower handgrip strength was associated with higher anxiety and depression symptoms in healthy university students, especially in female students. However, further longitudinal studies are needed to establish causality.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 20","pages":"e71143"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of aging on neck vasculature and brain biochemistry in female mice. 衰老对雌性小鼠颈部血管系统及脑生化的影响。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71059

Allison R Jones, Amin Jarrahi, Kylee Karpowich, EllaGrey Moody, Lily Renner, Lindsay P Brown, Caitlin M Tressler, A Colleen Crouch

{"title":"Impact of aging on neck vasculature and brain biochemistry in female mice.","authors":"Allison R Jones, Amin Jarrahi, Kylee Karpowich, EllaGrey Moody, Lily Renner, Lindsay P Brown, Caitlin M Tressler, A Colleen Crouch","doi":"10.14814/phy2.71059","DOIUrl":"10.14814/phy2.71059","url":null,"abstract":"Age-related changes in large-vessel biomechanics may contribute to neurovascular dysfunction and region-specific biochemical remodeling in the brain, with important implications for female health. This study investigated the impact of aging on neck vasculature and brain lipid biochemistry in female C57BL/6NHsd mice by comparing young (12 weeks; n = 10) and middle-aged (52 weeks; n = 10) cohorts using ultrasound imaging, histology, and mass spectrometry. In vivo ultrasound quantified carotid and jugular hemodynamics, including wall shear stress (WSS), circumferential cyclic strain (CCS), pulsatility index, and volumetric flow. Ex vivo assessments included spatial lipid mapping in vessels and brain, and histology staining to quantify elastin-to-collagen ratios. Middle-aged females exhibited reduced carotid systolic velocity, systolic WSS, and body weight-normalized carotid volumetric flow compared to young controls, while pulsatility index and CCS showed non-significant decreases. Histology revealed a reduction in the carotid elastin-to-collagen ratio, consistent with vascular remodeling. Lipidomic profiling identified age-dependent shifts in lipid headgroups, including decreases across multiple brain lipid classes, increased N-acylethanolamides, alongside increases in carotid cardiolipin and lysophosphatidylethanolamine. Hippocampal spectra showed clearer age-related separation than whole-brain analyses. Correlation analyses identified moderate to strong associations between vascular biomechanics and lipid features across tissues, supporting coordinated neurovascular and biochemical aging in female mice.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 17","pages":"e71059"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term imoxin treatment does not attenuate disease severity in dystrophic diaphragm of male mice. 长期伊莫辛治疗不能减轻雄性横膈膜营养不良小鼠的疾病严重程度。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71115

Ji Heun Lee, Morgan E Vorwald, Melissa Roths, Joshua T Selsby, Rudy J Valentine

{"title":"Long-term imoxin treatment does not attenuate disease severity in dystrophic diaphragm of male mice.","authors":"Ji Heun Lee, Morgan E Vorwald, Melissa Roths, Joshua T Selsby, Rudy J Valentine","doi":"10.14814/phy2.71115","DOIUrl":"10.14814/phy2.71115","url":null,"abstract":"Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle injury and degeneration. We discovered activation of protein kinase R (PKR; EIF2AK2), a regulator of the integrated stress response, in dystrophic muscle; however, its role in DMD remains unknown. We hypothesized that the PKR inhibitor imoxin (IMX) would improve muscle force and attenuate fibrosis, inflammatory signaling, and ER stress in diaphragms from mdx mice. C57 and mdx mice were treated with vehicle or IMX for ~24 wks (0.5 mg/kg, subcutaneous, 5 times/wk). Specific force was decreased (p < 0.001), and dynamic passive force was increased (p = 0.001) by disease, but there were no IMX effects. Disease-increased fibrotic area was decreased by IMX (p = 0.038); however, IMX failed to reduce fibronectin, collagen, or TGF-β1 signaling proteins. PKR and phosphorylated (p)PKR (thr446) were increased in mdx (p < 0.001) and maintained despite IMX treatment. Similarly, PKR regulators (total PACT, pPACT (ser18), TRBP, and PP1α), and PKR substrates (total eIF2α and peIF2α (ser51)) were also increased with disease (p < 0.001), but unaffected by IMX. Likewise, IMX did not attenuate disease-mediated elevations in inflammatory signaling and ER stress markers. Overall, the dose of IMX was insufficient to attenuate PKR activation and failed to improve muscle function or prevent pathology in dystrophic skeletal muscle.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 18","pages":"e71115"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lag-sensitive cross-correlation analysis of mother-infant HF-HRV synchrony during free interaction: An exploratory feasibility study. 自由互动中母婴HF-HRV同步的滞后敏感交叉相关分析：一项探索性可行性研究。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71116

Aoi Sakurai, Kunihiro Koide, Yoshiyuki Kasahara, Yasuka Nakamura, Toyoko Yoshizawa

{"title":"Lag-sensitive cross-correlation analysis of mother-infant HF-HRV synchrony during free interaction: An exploratory feasibility study.","authors":"Aoi Sakurai, Kunihiro Koide, Yoshiyuki Kasahara, Yasuka Nakamura, Toyoko Yoshizawa","doi":"10.14814/phy2.71116","DOIUrl":"10.14814/phy2.71116","url":null,"abstract":"Caregiver-infant interaction involves coordinated behavioral and physiological processes. Heart rate variability (HRV) may provide a physiological index of these interactions. This study preliminarily evaluated an analytical approach for characterizing mother-infant HRV synchrony with temporal lags. Electrocardiograms were simultaneously recorded during free interaction. Thirty sessions were obtained from 15 mother-infant dyads, and 16 analyzable sessions from 10 unique dyads were included in the final analysis. Normalized cross-correlation analysis of high-frequency HRV was performed using MATLAB R2022b. Highly correlated intervals accounted for a mean of 75% of the analyzed interaction time, and positive and negative lags occurred in nearly equal proportions. Observed synchrony exceeded the session-specific surrogate distribution in 13 of 16 sessions based on the empirical p-value criterion. These findings support the feasibility of a lag-sensitive, surrogate-informed approach for preliminarily describing putative mother-infant HRV coordination during free interaction.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 18","pages":"e71116"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute high-protein feeding induces hepatic amino acid accumulation in diabetic male mice prior to transcriptional adaptation. 急性高蛋白喂养诱导糖尿病雄性小鼠在转录适应之前肝脏氨基酸积累。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71117

Hiroaki Sumioki, Eisuke Tomatsu, Yusuke Seino, Shihomi Hidaka, Shinji Ueno, Sayumi Kanie, Koki Nishida, Takuya Haraguchi, Naoya Murao, Haruki Fujisawa, Takeshi Takayanagi, Yoshihisa Sugimura, Yoshitaka Hayashi, Atsushi Suzuki

{"title":"Acute high-protein feeding induces hepatic amino acid accumulation in diabetic male mice prior to transcriptional adaptation.","authors":"Hiroaki Sumioki, Eisuke Tomatsu, Yusuke Seino, Shihomi Hidaka, Shinji Ueno, Sayumi Kanie, Koki Nishida, Takuya Haraguchi, Naoya Murao, Haruki Fujisawa, Takeshi Takayanagi, Yoshihisa Sugimura, Yoshitaka Hayashi, Atsushi Suzuki","doi":"10.14814/phy2.71117","DOIUrl":"10.14814/phy2.71117","url":null,"abstract":"Glucagon plays a pivotal role in hepatic amino acid metabolism; acute high-protein diet feeding and diabetic condition both induce enhanced glucagon secretion. However, it remains unknown whether these two conditions alter hepatic amino acid metabolism through the same or different pathways. In this study, streptozotocin-induced diabetic (STZ-D) and nondiabetic (ND) mice received liquid normal control (LNC) or liquid high-protein (LHP) diet. Plasma and hepatic parameters were analyzed 2 h post-feeding. LHP increased plasma essential amino acids in both groups. Hepatic amino acid accumulation in LHP-fed STZ-D mice was increased compared to that in LNC-fed STZ-D mice but not in ND mice. In addition, LHP reduced hepatic glycogen while the expression of amino acid metabolism and urea cycle genes remained unchanged both in ND and STZ-D mice. Compared with ND mice, STZ-D mice showed upregulation of genes involved in gluconeogenesis and amino acid metabolism, together with an accumulation of early glycolytic intermediates and glycogen. These findings indicate that acute high-protein intake induces non-transcriptional regulation of amino acid metabolism within 2 h. The altered hepatic amino acid profile in STZ-D mice is likely to be driven by increased hepatic amino acid uptake and accelerated gluconeogenesis.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 18","pages":"e71117"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149063666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bedtime tetrahydrocannabinol ingestion reduces morning orthostatic cardiovascular reactivity in adults: An exploratory study. 睡前摄入四氢大麻酚可降低成人晨位性心血管反应：一项探索性研究。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71076

Joshua E Gonzalez, Alicia V Stewart, LaTroy D Robinson, Noal A Clemons, Omar H Ordaz, Jonathan S Emens, Saurabh S Thosar, Steven A Shea, Nicole P Bowles

{"title":"Bedtime tetrahydrocannabinol ingestion reduces morning orthostatic cardiovascular reactivity in adults: An exploratory study.","authors":"Joshua E Gonzalez, Alicia V Stewart, LaTroy D Robinson, Noal A Clemons, Omar H Ordaz, Jonathan S Emens, Saurabh S Thosar, Steven A Shea, Nicole P Bowles","doi":"10.14814/phy2.71076","DOIUrl":"10.14814/phy2.71076","url":null,"abstract":"Acute cannabis use and its primary psychoactive constituent tetrahydrocannabinol (THC) can induce postural dizziness, indicating increased risk of orthostatic instability. However, it is unknown if vulnerabilities persist the morning after bedtime THC consumption. This study investigated the influence of bedtime THC consumption on cardiovascular variables during an orthostatic challenge. Nine individuals with no cannabis use and eight individuals who regularly use cannabis participated in a tilt table test associated with a 3-day in-laboratory stay. Participants underwent an acclimatization day, followed by a placebo dosing day, and a 10 mg THC dosing day. Placebo and THC pills were given 1 h before a participant's habitual bedtime, and the tilt table test was performed ~1 h upon awakening. Participants were instrumented with an electrocardiogram and an automated sphygmomanometer. Fluid intake and output were measured throughout the study. The morning after THC administration, individuals with no cannabis use reported a higher frequency of dizziness and exhibited a significant reduction in both diastolic blood pressure and heart rate reactivity to tilt (reactivity = tilt - baseline) compared to the morning after placebo. Our results indicate a potential increased risk for orthostatic instability the morning after cannabis consumption in individuals with no cannabis use history.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 17","pages":"e71076"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature-driven modulation of factors influencing full-Marathon time in male recreational runners. 男性休闲跑者全程马拉松时间影响因素的温度驱动调节。

IF 2.1

Physiological Reports Pub Date : 2026-09-01 DOI: 10.14814/phy2.71096

Koshiro Inoue, Akihiko Yamaguchi, Yoshiharu Nabekura, Toru Ishihara, Takemune Fukuie

{"title":"Temperature-driven modulation of factors influencing full-Marathon time in male recreational runners.","authors":"Koshiro Inoue, Akihiko Yamaguchi, Yoshiharu Nabekura, Toru Ishihara, Takemune Fukuie","doi":"10.14814/phy2.71096","DOIUrl":"10.14814/phy2.71096","url":null,"abstract":"The weather during full-marathon events is expected to become warmer due to global warming, making heat preparations a key challenge for runners. To gain insight into this challenge, we examined whether associations between full-marathon finish time and selected factors differed across the Tsukuba Marathon 2023 and 2022, and the Hokkaido Marathon 2023, which represent optimal, moderate, and extreme temperatures, respectively. Questionnaire-based measurements of full-marathon personal best (PB), age, running experience (career), body mass index (BMI), weekly running distance and frequency, longest running distance, and finish time were analyzed using hierarchical multiple regression analysis, followed by simple slope analyses for significant interactions. The analysis included 1938 male runners. Event-based ambient temperature conditions independently explained approximately 11% of the variance in finish time. Temperature conditions significantly modulated the relationships between finish time and PB, age, career, and BMI, whereas no such effect was observed for running distance, frequency, and longest run. Specifically, the temperature-related increase in finish time tended to be greater in runners characterized by faster PB time, older age, lower career values, and higher BMI. Running capacity, age, running experience, and BMI may serve as key targets in strategies to counteract heat-related marathon performance decline in male recreational runners.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"14 17","pages":"e71096"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0