Physiological Reports最新文献_第4页

Text phrase-mining in identifying and classifying maternal proteins and genes across preeclampsia and similar pathologies.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70262

Jacqueline G Urdang, Stephanie Masters, Nneoma Edokobi, Chitra Mukherjee, Arnib Quazi, David A Liem, Monica Ahrens, Xuan Wang, Megan Whitham

{"title":"Text phrase-mining in identifying and classifying maternal proteins and genes across preeclampsia and similar pathologies.","authors":"Jacqueline G Urdang, Stephanie Masters, Nneoma Edokobi, Chitra Mukherjee, Arnib Quazi, David A Liem, Monica Ahrens, Xuan Wang, Megan Whitham","doi":"10.14814/phy2.70262","DOIUrl":"10.14814/phy2.70262","url":null,"abstract":"This study aims to demonstrate that text phrase-mining and natural language processing (NLP) can annotate huge quantities of obstetrics textual data for the discovery and evaluation of maternal protein/gene (MPG)-disease interactions involved in the preeclampsia pathway. We employ a phrase-mining/NLP pipeline to evaluate unique MPGs involved in six cardiovascular derangements with overlapping presentations during pregnancy. The diseases were matched with Medical Subject Headings. A textual corpus was developed from abstracts matched to these terms through PubMed. Fourty-four MPGs were identified with respect to the diseases. Processing was performed, with unique scores for each MPG-disease pair. Components of the score were calculated and weighted for distinctness, integrity, and popularity. Statistical analyses were conducted for the examination of protein-disease relationships. Fourty-four MPGs with known associations to cardiovascular disease and preeclampsia pathways were identified among the 6 diseases. MPGs shared across the greatest number of disease states were implicated in: (1) angiogenesis and vasoconstriction, (2) hemodynamic regulation, (3) hormonal regulation of metabolism, and (4) inflammation. NLP and text phrase-mining are successfully applied to Obstetrics abstracts with accuracy and speed. This approach holds promise in synthesizing large volumes of data for presenting trends in the Obstetric literature and for the identification of promising biomarkers.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70262"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal steroid hormone responses to exercise under thermal stress: Potential role for nonclassic congenital adrenal hyperplasia in heat illness susceptibility.

IF 2.2

Physiological Reports Pub Date : 2025-03-01 DOI: 10.14814/phy2.70272

Michael J Stacey, Carol House, Daniel Roiz de Sa, Stephen J Brett, Christopher Boot, Andrew Teggert, Adrian J Allsopp, David R Woods

{"title":"Adrenal steroid hormone responses to exercise under thermal stress: Potential role for nonclassic congenital adrenal hyperplasia in heat illness susceptibility.","authors":"Michael J Stacey, Carol House, Daniel Roiz de Sa, Stephen J Brett, Christopher Boot, Andrew Teggert, Adrian J Allsopp, David R Woods","doi":"10.14814/phy2.70272","DOIUrl":"10.14814/phy2.70272","url":null,"abstract":"We queried whether adrenal insufficiency attributable to non-classic congenital adrenal hyperplasia (21 hydroxylase deficiency, 21OHD) might contribute to heat illness susceptibility. Patients referred to a specialist heat illness clinic (n = 2 with prior hyponatremia; n = 16 lacking documentary evidence) and controls (n = 16) underwent laboratory Heat Tolerance Assessment (HTA: 60-90 min walking, 60% relative intensity, 34°C heat), synthetic adrenocorticotrophic hormone stimulation (heat illness only) and CYP21A2 genotyping (hyponatremic heat illness only). Copeptin, cortisol, 17-hydroxyprogesterone, and 21 deoxycortisol were assayed from blood at baseline and post-HTA, with precursor product [17-hydroxyprogesterone +21 deoxycortisol] expressed relative to cortisol. Saliva and urine were assayed for free cortisol (one hyponatremic case, controls). Versus controls, normonatremic heat illness exhibited greater (p < 0.05) serum cortisol across HTA, while hyponatremic heat illness showed blunted responses in aldosterone and free cortisol (salivary cortisol 1.6 and 1.6 vs. 6.0 [4.2, 19.4] and 4.2 [3.8, 19.2] nmol.L-1; urine cortisol 19 vs. 117 +/- 71 nmol.L-1). Hyponatremic heat illness demonstrated elevated precursor product consistent with 21OHD and multiple CYP21A2 mutations. One normonatremic case of heat illness also showed elevated precursor product. These data support the potential for 21OHD to precipitate heat illness under sustained physical stress and advance a case for targeted genetic screening.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 6","pages":"e70272"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between circulating amino acids and metabolic dysfunction-associated steatotic liver disease in individuals living with severe obesity.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70171

Ina Maltais-Payette, Jérôme Bourgault, Marie-Frédérique Gauthier, Laurent Biertho, Simon Marceau, François Julien, Patricia L Mitchell, Christian Couture, Francis Brière, Jacques Corbeil, Benoit J Arsenault, André Tchernof

{"title":"Associations between circulating amino acids and metabolic dysfunction-associated steatotic liver disease in individuals living with severe obesity.","authors":"Ina Maltais-Payette, Jérôme Bourgault, Marie-Frédérique Gauthier, Laurent Biertho, Simon Marceau, François Julien, Patricia L Mitchell, Christian Couture, Francis Brière, Jacques Corbeil, Benoit J Arsenault, André Tchernof","doi":"10.14814/phy2.70171","DOIUrl":"10.14814/phy2.70171","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) describes liver diseases caused by the accumulation of triglycerides in hepatocytes (steatosis) as well as the resulting inflammation and fibrosis. Previous studies have demonstrated that accumulation of fat in visceral adipose tissue compartments and the liver is associated with alterations in the circulating levels of some amino acids, notably glutamate. This study aimed to investigate the associations between circulating amino acids, particularly glutamate, and MASLD. In addition, we hypothesized that liver steatosis, concomitant with visceral adiposity, could contribute to the association between circulating glutamate and visceral obesity. We studied a sample of 150 patients living with severe obesity who were non-diabetic and selected to represent a wide range of MASLD severity. Liver histological features were determined by a pathologist from a biopsy sample obtained at the time of bariatric surgery. Bulk RNA sequencing measured the hepatic mRNA expression level of selected genes related to the urea cycle and glutamate metabolism. Fasting plasma amino acid levels were measured by liquid chromatography coupled with tandem mass spectrometry. Patients with more advanced steatosis had larger visceral adipocytes, higher levels of circulating tyrosine, glutamate, and alanine as well as lower levels of serine. MASLD severity was significantly associated with the hepatic mRNA expression of glutamate metabolism genes such as GLS1, GLUL (positively), and NAGS (inversely). In individuals living with obesity, MASLD severity is associated with visceral adipocyte hypertrophy, higher circulating glutamate as well as potential alterations of hepatic amino acid and nitrogen metabolism.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70171"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70135

Kunihiko Takahara, Noriyuki Ouchi, Tomonobu Takikawa, Yuta Ozaki, Lixin Fang, Hiroshi Kawanishi, Minako Tatsumi, Yoshimitsu Yura, Katsuhiro Kato, Mikito Takefuji, Toyoaki Murohara, Koji Ohashi

{"title":"Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice.","authors":"Kunihiko Takahara, Noriyuki Ouchi, Tomonobu Takikawa, Yuta Ozaki, Lixin Fang, Hiroshi Kawanishi, Minako Tatsumi, Yoshimitsu Yura, Katsuhiro Kato, Mikito Takefuji, Toyoaki Murohara, Koji Ohashi","doi":"10.14814/phy2.70135","DOIUrl":"10.14814/phy2.70135","url":null,"abstract":"Chronic kidney disease is a life-threatening disease worldwide. PPARα is a crucial transcriptional regulator of lipid metabolism and inflammation. Here, we examine whether a novel selective PPARα modulator, pemafibrate modulates renal injury in a model of unilateral ureteral obstruction (UUO). Administration of pemafibrate to wild-type (WT) mice led to reduction of renal dysfunction and fibrosis after UUO with accompanying increases in plasma levels of fibroblast growth factor (FGF) 21 and ketone body β-hydroxybutyrate (BHB). Treatment of WT mice with FGF21 or BHB precursor resulted in attenuation of renal fibrotic and inflammatory responses after UUO. Treatment of proximal tubular cells with FGF21 or BHB reduced expression of epithelial-mesenchymal transition markers. These findings suggest that pemafibrate could ameliorate renal damage, at least in part, by its abilities to increase the production of FGF21 and BHB.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70135"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of home-based hot bathing on exercise-induced adaptations associated with short-term resistance exercise training in young men.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70188

Ryosuke Takeda, Tsubasa Amaike, Taichi Nishikawa, Kohei Watanabe

{"title":"Effect of home-based hot bathing on exercise-induced adaptations associated with short-term resistance exercise training in young men.","authors":"Ryosuke Takeda, Tsubasa Amaike, Taichi Nishikawa, Kohei Watanabe","doi":"10.14814/phy2.70188","DOIUrl":"10.14814/phy2.70188","url":null,"abstract":"This study investigated whether home-based bathing intervention (HBBI) improve muscle strength gain and protect cardiovascular function by short-term resistance training (RT). Thirty-one healthy young men measured the maximum voluntary isometric contraction (MVC) of knee extensor, electrically evoked knee extension torque, and mean arterial pressure (MAP). Then, participants were divided into three groups with matching MVC: shower without bathing (control, n = 10), thermoneutral bathing (36°C-bathing, n = 10), and hot bathing (40°C-bathing, n = 11), and conducted 2 weeks of HBBI. Following familiarization for HBBI, participants completed 2 weeks of HBBI and acute RT (five sessions of three sets of 10 isometric knee extension at 60% MVC). Baseline neuromuscular and cardiovascular function was assessed again following completion of the 2 weeks of intervention. MVC was non-significantly increased after the RT period in 40°C-bathing with large effect size (partial η2 = 0.450). The electrically evoked knee extension torque (10/100-Hz ratio) was significantly increased after the RT period in control (p = 0.020). MAP did not alter due to bathing intervention and RT (all p > 0.05). HBBI improved muscle strength without RT-induced alteration of peripheral muscle condition. Shower without bathing reduced muscle strength gain but increased peripheral muscle condition. Short-term RT does not adversely affect the cardiovascular function, regardless of HBBI.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70188"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70232

Lokesh Sharma, Ravineel B Singh, Caden Ngeow, Rick van der Geest, Alexis M Duray, Nathanial J Tolman, Bryan J McVerry, Charles S Dela Cruz, John F Alcorn, William Bain, Keven M Robinson

{"title":"Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.","authors":"Lokesh Sharma, Ravineel B Singh, Caden Ngeow, Rick van der Geest, Alexis M Duray, Nathanial J Tolman, Bryan J McVerry, Charles S Dela Cruz, John F Alcorn, William Bain, Keven M Robinson","doi":"10.14814/phy2.70232","DOIUrl":"10.14814/phy2.70232","url":null,"abstract":"Influenza infections are often complicated by secondary bacterial infections such as MRSA pneumonia, which increase morbidity and mortality. Viral infections lead to an inflammatory response that includes elevated levels of IL-6 and interferons. IL-6 activates the JAK/STAT signaling pathway, amplifying downstream inflammation. Given the clinical efficacy of the JAK inhibitor baricitinib in reducing disease severity in COVID-19, we evaluated its impact in a murine model of influenza, MRSA, and post-influenza MRSA pneumonia. Additionally, because IL-6 inhibitory therapies have improved outcomes during COVID-19, we evaluated the impact of IL-6 deletion on post-influenza MRSA pneumonia. In our studies, baricitinib effectively inhibited the JAK/STAT pathway in the lungs, as demonstrated by decreased interferon-stimulated genes (ISGs) and STAT3 phosphorylation. Despite this inhibition, baricitinib did not cause a global suppression of cytokines. Notably, baricitinib treatment did not impair either antiviral or antibacterial host immunity, inflammatory cell recruitment, or lung tissue injury. IL-6 deficiency did not alter weight loss, inflammatory cell recruitment, or bacterial burden during post-influenza MRSA pneumonia. These findings suggest that both JAK inhibition via baricitinib and IL-6 deletion do not enhance host defense or limit tissue injury in murine models of influenza and post-influenza MRSA pneumonia.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70232"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining the predictors for post renal transplant left ventricular dysfunction in end-stage renal disease patients.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70198

Mahboobeh Sheikhani, Hoorak Poorzand, Mahnaz Ahmadi, Negar Morovatdar, Sara Afshar, Zahra Shahinfar

{"title":"Defining the predictors for post renal transplant left ventricular dysfunction in end-stage renal disease patients.","authors":"Mahboobeh Sheikhani, Hoorak Poorzand, Mahnaz Ahmadi, Negar Morovatdar, Sara Afshar, Zahra Shahinfar","doi":"10.14814/phy2.70198","DOIUrl":"10.14814/phy2.70198","url":null,"abstract":"Reduced left ventricular (LV) function predicts poor outcomes in end-stage renal disease (ESRD). This study aimed to identify the pre-renal transplantation echocardiographic parameters that can predict post-renal transplantation LV failure. This prospective longitudinal study was conducted on patients with ESRD who underwent renal transplantation during 1 year. All patients underwent echocardiography, including ejection fraction (EF), global longitudinal strain (GLS), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic diameter (LVEDD), interventricular septal (IVS) thickness, peak velocity of early diastolic transmitral flow (E), peak velocity of late transmitral flow (A), early diastolic myocardial relaxation (Em), E/A, E/Em, Left atrial volume (LAV) index, tricuspid regurgitation peak gradient (TRPG), systolic pulmonary artery pressure (SPAP), tricuspid annular plane systolic excursion (TAPSE), 1 week before and 1 month after renal transplantation. Fifty patients participated in the current study. All echocardiographic parameters improved after transplantation. Post-renal transplantation LV dysfunction was observed in 21 (42%) patients. Pre-renal transplantation echocardiographic parameters (LVEDV, LVESD, LVEDD, IVS, E/Em, TRPG, SPAP, and LAV index) could predict post-transplantation LV failure with high accuracy (AUC: 0.978).","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70198"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive operative risk assessment driving the application of major and emergency surgery in octogenarians.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70214

Francesco Puccetti, Alessandro Francesco Armienti, Stefano Turi, Lorenzo Cinelli, Riccardo Rosati, Ugo Elmore

引用次数: 0

Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH-promoting GAN diet and a high-fat diet.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70235

Katrine D Galsgaard, Emilie Elmelund, Jenna E Hunt, Mark M Smits, Trisha J Grevengoed, Christina Christoffersen, Nils J Færgeman, Jesper Havelund, Nicolai J Wewer Albrechtsen, Jens J Holst

{"title":"Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH-promoting GAN diet and a high-fat diet.","authors":"Katrine D Galsgaard, Emilie Elmelund, Jenna E Hunt, Mark M Smits, Trisha J Grevengoed, Christina Christoffersen, Nils J Færgeman, Jesper Havelund, Nicolai J Wewer Albrechtsen, Jens J Holst","doi":"10.14814/phy2.70235","DOIUrl":"10.14814/phy2.70235","url":null,"abstract":"Glucagon is secreted from the pancreatic alpha cells and regulates not only hepatic glucose production, but also hepatic lipid and amino acid metabolism. Thus, glucagon provides a switch from hepatic glucose and lipid storage towards lipid and amino acid breakdown fueling glucose production during fasting. However, the effects of genetic deletion of the glucagon receptor on lipid metabolism are unclear. We therefore assessed parameters of lipid metabolism in fasted and non-fasted male and female mice with permanent whole-body deletion of the glucagon receptor (Gcgr-/- mice). To investigate whether Gcgr-/- mice tolerated a diet promoting metabolic dysfunction-associated steatohepatitis (MASH) and steatosis, we fed female Gcgr-/- mice the Gubra Amylin Nonalcoholic steatohepatitis (GAN) diet and high-fat diet (HFD), respectively. We found that non-fasted Gcgr-/- mice fed standard chow showed hypercholesterolemia and increased liver fat (borderline significant in non-fasted male Gcgr-/- mice, but significant in the remaining groups). In the fasted state these changes were insignificant due to fasting-induced steatosis. When challenged with a GAN diet and HFD, female Gcgr-/- mice were prone to steatosis and dyslipidemia but resistant to weight gain. Taken together, our data highlight glucagon as an important physiological regulator of not just glucose, but also hepatic lipid metabolism.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 4","pages":"e70235"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.

IF 2.2

Physiological Reports Pub Date : 2025-02-01 DOI: 10.14814/phy2.70206

Mario Parstorfer, Gernot Poschet, Kirsten Brüning, Birgit Friedmann-Bette

{"title":"Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.","authors":"Mario Parstorfer, Gernot Poschet, Kirsten Brüning, Birgit Friedmann-Bette","doi":"10.14814/phy2.70206","DOIUrl":"10.14814/phy2.70206","url":null,"abstract":"Little is known about the exercise-induced adaptations of the metabolome in endurance and strength athletes in comparison with sedentary subjects. In order to analyze exercise-induced effects, quantitative, targeted metabolomics (Biocrates MxP® Quant 500) were performed in plasma samples before and after one bout of endurance or resistance exercise (RE) in 12 strength-trained weightlifters (ST), 10 endurance-trained runners (ET) and 12 sedentary controls (CG) at the end of each of three characteristic training phases. Performance and anthropometric data were significantly different between CG and athletes. A significant exercise-induced increase in lactate (Lac) was observed in all groups after all exercise tests. After endurance exercise (EE), there were significant increases in acetylcarnitine, arachidonic acid, and docosahexaenoic acid in CG and ET while aconitic acid, hippuric acid, glutamate, hexoses, xanthine were significantly increased in ET only. Only CG showed increases in several triglycerides following EE. RE, however, induced significant increases in Lac only. In summary, EE induces distinct increases in some metabolites of the fatty acid metabolism and the oxidative defense system in ET and CG. There are some indications for specific adaptations of the energy metabolism after long lasting endurance training with a distinct exercise-induced response of the metabolome in ET.","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 3","pages":"e70206"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0