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Sex differences in exercise-induced arterial hypoxemia and pulmonary edema following high-intensity exercise in highly trained endurance athletes. 训练有素的耐力运动员在高强度运动后运动引起的动脉低氧血症和肺水肿的性别差异。
IF 2.2
Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70190
Alanna S Hind, Reid A Mitchell, Olivia N Ferguson, Morgan Flynn, Satvir S Dhillon, Karine Badra, Kathryn M Milne, Danilo Iannetta, Michael S Koehle, Jordan A Guenette
{"title":"Sex differences in exercise-induced arterial hypoxemia and pulmonary edema following high-intensity exercise in highly trained endurance athletes.","authors":"Alanna S Hind, Reid A Mitchell, Olivia N Ferguson, Morgan Flynn, Satvir S Dhillon, Karine Badra, Kathryn M Milne, Danilo Iannetta, Michael S Koehle, Jordan A Guenette","doi":"10.14814/phy2.70190","DOIUrl":"10.14814/phy2.70190","url":null,"abstract":"<p><p>This study investigated sex differences in the development of pulmonary edema and exercise-induced arterial hypoxemia (EIAH) in well-trained endurance athletes during near-maximal exercise in a real-world setting. Twenty participants (10M vs. 10F; V̇O<sub>2</sub>peak: 69.3 (8.8) vs. 50.7 (4.1) ml∙kg<sup>-1</sup>∙min<sup>-1</sup>) underwent a maximal incremental treadmill test (visit 1) and a time trial on a steep trail (~2.5 km, ~800 m elevation gain) in North Vancouver (visit 2). Pulmonary edema was evaluated using handheld lung ultrasound ~10-15 min post-exercise and oxygen saturation (SpO<sub>2</sub>) was monitored using finger pulse oximetry. Males completed the time trial significantly faster than females (M: 31.5 (6.5) vs. F: 40.4 (7.5) min, p = 0.006), while females sustained a higher percentage of their visit 1 heart rate (M: 94 (1) vs. F: 96 (1) %max, p = 0.02). All participants developed EIAH, with no sex differences in end-exercise SpO<sub>2</sub> (M: 89 (4) % vs. F: 90 (3) %, respectively, p = 0.35). There was no evidence of pulmonary edema, assessed through ultrasound b-line scores, with no differences between sexes (M: 0.3 (1.0) vs. F: 0.5 (1.5), respectively, p = 0.60). Pulmonary edema is an unlikely contributor to EIAH in endurance athletes performing near-maximal time trial exercise in a real-world setting.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70190"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twin testosterone transfer hypothesis and the second-to-fourth digit ratio in females of same-sex and opposite-sex twin pairs: An exploratory study.
IF 2.2
Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70207
Moses Banyeh, Martha Nyewie, Abdul-Rafik Abdulai, Charles Nkansah, Gabriel Abbam, Thea Kangkpi, Kervin Edinam Zogli, Shafiat Omotoyosi Shittu, David Bure, Romarick Kofi Wemegah, Mikail Ihsan Azindow, Suleman Yakubu, Musah Seidu, Mohammed Madde Baba, Elisha Essoun, Nancy Owireduwaa, Augusta S Kolekang
{"title":"Twin testosterone transfer hypothesis and the second-to-fourth digit ratio in females of same-sex and opposite-sex twin pairs: An exploratory study.","authors":"Moses Banyeh, Martha Nyewie, Abdul-Rafik Abdulai, Charles Nkansah, Gabriel Abbam, Thea Kangkpi, Kervin Edinam Zogli, Shafiat Omotoyosi Shittu, David Bure, Romarick Kofi Wemegah, Mikail Ihsan Azindow, Suleman Yakubu, Musah Seidu, Mohammed Madde Baba, Elisha Essoun, Nancy Owireduwaa, Augusta S Kolekang","doi":"10.14814/phy2.70207","DOIUrl":"10.14814/phy2.70207","url":null,"abstract":"<p><p>The twin testosterone transfer (TTT) hypothesis posits that females with male co-twins (opposite-sex, OS) might develop male-typical traits due to higher prenatal testosterone exposure. This study explored whether females of OS have lower 2D:4D digit ratios and higher testosterone levels compared to females of same-sex (SS) twin pairs. Conducted in Tamale from January to December 2022, the study included 40 participants aged 18-27 years: 10 males of OS, 10 females of OS, and 20 females of SS twin pairs. Digit ratios (2D:4D) and serum testosterone levels were measured using computer-assisted analysis and ELISA, respectively. Results showed no significant differences in 2D:4D ratios between females of OS and SS twin pairs for either the right hand (0.960 ± 0.049 vs. 0.955 ± 0.042; p = 0.766) or the left hand (0.966 ± 0.048 vs. 0.968 ± 0.047; p = 0.908). Serum testosterone levels were lower in females of OS than females of SS twin pairs (0.4 ± 0.1 vs. 0.67 ± 0.34 nmol/L; p = 0.013), but this result was not significant after multiple testing corrections (p > 0.050). The findings indicate that the TTT hypothesis may not apply, or its effects on digit ratios and testosterone levels in females of OS twin pairs are weak and not statistically significant. Further studies involving larger samples are however, recommended.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 2","pages":"e70207"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PSTK exerts protective role in cisplatin-tubular cell injury via BAX/BCL2/Caspase3 pathway. PSTK通过BAX/BCL2/Caspase3通路在顺铂-小管细胞损伤中发挥保护作用。
IF 2.2
Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70162
Yifan Wu, Yuanyuan Xv, Limei Zhao, Ziqi Zhou, Miaomiao Wang, Jima Xi, Ying Liming, Jianling Gao, Bingqing Deng, Dong Zheng
{"title":"PSTK exerts protective role in cisplatin-tubular cell injury via BAX/BCL2/Caspase3 pathway.","authors":"Yifan Wu, Yuanyuan Xv, Limei Zhao, Ziqi Zhou, Miaomiao Wang, Jima Xi, Ying Liming, Jianling Gao, Bingqing Deng, Dong Zheng","doi":"10.14814/phy2.70162","DOIUrl":"10.14814/phy2.70162","url":null,"abstract":"<p><p>Cisplatin is a widely used anticancer drug, but its accumulation in renal tubular epithelial cells (TECs) can cause acute kidney injury. Phosphoseryl-tRNA kinase (PSTK) is an intermediate product produced under oxidative stress conditions. This study aimed to elucidate whether PSTK could protect TECs and its possible mechanisms. We found that PSTK levels decreased after cisplatin treatment, but PSTK overexpression using lentivirus vectors protected TEC viability. Overexpression of PSTK increased selenoprotein concentrations and reduced intracellular ROS levels. Additionally, PSTK overexpression inhibited the BAX/BCL2/Caspase 3 pathway after cisplatin stimulation, suggesting its potential role in preventing cell apoptosis. Taken together, this study suggests that PSTK could protect TEC viability from cisplatin-induced injury, possibly by inhibiting mitochondrial apoptosis. The study is significant for developing therapeutic strategies that could manipulate PSTK to delay AKI progression.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70162"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of time-restricted feeding and meal timing on an 8-week fat oxidation exercise training program-A randomized controlled trial. 限时进食和进餐时间对8周脂肪氧化运动训练计划的影响——一项随机对照试验
IF 2.2
Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70194
Florian Hofstätter, Martin Niedermeier, Linda K Rausch, Martin Kopp, Lydia Simpson, Justin S Lawley
{"title":"Effects of time-restricted feeding and meal timing on an 8-week fat oxidation exercise training program-A randomized controlled trial.","authors":"Florian Hofstätter, Martin Niedermeier, Linda K Rausch, Martin Kopp, Lydia Simpson, Justin S Lawley","doi":"10.14814/phy2.70194","DOIUrl":"10.14814/phy2.70194","url":null,"abstract":"<p><p>Time-restricted feeding (TRF) and aerobic exercise are lifestyle interventions to prevent or manage different metabolic diseases. How these interventions interact, including the impact of meal timing, is not well understood. The aim of this study was to examine the influence of TRF on fat oxidation during exercise, whereby participants performed an 8-week fat<sub>max</sub>-training program either in the fasted state or after a carbohydrate-based snack. 36 participants were randomized into three groups. (1) Training sessions were performed in the fasted state; (2) Training sessions were performed after consuming a standardized carbohydrate-based snack; (3) Exercise training with an ad libitum diet as a control group. Pre- and post-tests included anthropometric measurements and a fat<sub>max</sub>-cycle-ergometry protocol to measure substrate oxidation. Data were analyzed as workload-matched and maximal fat oxidation using a series of mixed ANOVAs. Workload-matched (p = 0.038) and maximal (p < 0.001) fat oxidation improved in all groups. No significant group × time interactions were found in substrate utilization. Time had a significant effect on body weight (p = 0.011), fat mass (p < 0.001), and muscle mass (p < 0.001). Results suggest that fat<sub>max</sub> exercise training leads to improvements in fat oxidative capacity independent of fed or fasted state.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 2","pages":"e70194"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise. 慢性肾脏疾病的运动限制:一项腿部和手臂运动的实验性初步研究。
IF 2.2
Physiological Reports Pub Date : 2025-01-01 DOI: 10.14814/phy2.70200
Helena Wallin, Eva Jansson, Ragad Said, Sigrid Lundberg, Pourya Zolfaghardidani, Maria J Eriksson, Anette Rickenlund, Patrik Sundblad
{"title":"Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise.","authors":"Helena Wallin, Eva Jansson, Ragad Said, Sigrid Lundberg, Pourya Zolfaghardidani, Maria J Eriksson, Anette Rickenlund, Patrik Sundblad","doi":"10.14814/phy2.70200","DOIUrl":"10.14814/phy2.70200","url":null,"abstract":"<p><p>Maximal oxygen uptake (VO<sub>2</sub>max) in healthy subjects is primarily limited by systemic oxygen delivery. In chronic kidney disease (CKD), VO<sub>2</sub>max is potentially reduced by both central and peripheral factors. We aimed to investigate the effect on VO<sub>2</sub>peak of adding arm exercise to leg exercise. Ten individuals with CKD stages 3-5 and 10 healthy controls, matched for age, sex, body size, and physical activity level, were included. Subjects performed two maximal exercise tests, one with legs only (L exercise) and one test where arm exercise was added to leg exercise (LA exercise). The increase in VO<sub>2</sub>peak, when comparing LA exercise with L exercise, was significantly higher in CKD (0.20 ± 0.18 L/min or 2.31 ± 1.78 mL/(kg·min)) than in controls (0.019 ± 0.12 L/min or 0.26 ± 1.62 mL/(kg·min); p = 0.02 and 0.01, respectively). The decrease in peak leg workload, when comparing L exercise with LA exercise, was larger in controls than in CKD, in absolute terms (p = 0.002) and relative to body weight (p = 0.01). VO<sub>2</sub>max in individuals with CKD is dependent on the active muscle mass, supporting a peripheral limitation to VO<sub>2</sub>max in CKD. By contrast, the control group appeared to have a more central limitation to VO<sub>2</sub>max.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 1","pages":"e70200"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zbtb7b defines a compensatory mechanism in MASLD-related HCC progression by suppressing H19-mediated hepatic lipid deposition. Zbtb7b通过抑制h19介导的肝脂质沉积,确定了masld相关HCC进展的代偿机制。
IF 2.2
Physiological Reports Pub Date : 2024-12-01 DOI: 10.14814/phy2.70160
Yinglin Han, Kaimin Wu, Xin Peng, Yinkun Fu, Wenyan Li, Jing Ma, He Jiang, Xu-Yun Zhao
{"title":"Zbtb7b defines a compensatory mechanism in MASLD-related HCC progression by suppressing H19-mediated hepatic lipid deposition.","authors":"Yinglin Han, Kaimin Wu, Xin Peng, Yinkun Fu, Wenyan Li, Jing Ma, He Jiang, Xu-Yun Zhao","doi":"10.14814/phy2.70160","DOIUrl":"10.14814/phy2.70160","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is a widely prevalent type of primary liver cancer. However, strategies for pretumor intervention are still limited. In this study, a liver-specific Zbtb7b knockout mouse model was used to evaluate the role of Zbtb7b in metabolic dysfunction-associated steatotic liver disease (MASLD)-related HCC development. We revealed that Zbtb7b was compensatively increased and restricted lipid deposition in the liver during MASLD progression, which protects against MASLD-related HCC initiation. Mechanistically, Zbtb7b suppresses the expression of the long noncoding RNA H19 to attenuate hepatic de novo lipogenesis and increase fatty acid oxidation, thereby preventing lipid accumulation in hepatocytes. As a result, the proliferation and migration abilities of HCC cells are reduced. Overall, we demonstrated that Zbtb7b serves as a tumor suppressor at an early stage of HCC, thus providing a promising target for the treatment of HCC at a premalignant stage.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"12 24","pages":"e70160"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle contractile properties and perceived fatigue in the general and diseased population. 一般人群和患病人群的肌肉收缩特性和感知疲劳。
IF 2.2
Physiological Reports Pub Date : 2024-12-01 DOI: 10.14814/phy2.70134
Isa H Mast, Neeltje A E Allard, Dominique Ten Haaf, Anouk A F Stoffels, Lando Janssen, Hieronymus W H van Hees, Silvie Timmers, Bregina T P Hijmans-Kersten, Maria T E Hopman, Laurien M Buffart
{"title":"Muscle contractile properties and perceived fatigue in the general and diseased population.","authors":"Isa H Mast, Neeltje A E Allard, Dominique Ten Haaf, Anouk A F Stoffels, Lando Janssen, Hieronymus W H van Hees, Silvie Timmers, Bregina T P Hijmans-Kersten, Maria T E Hopman, Laurien M Buffart","doi":"10.14814/phy2.70134","DOIUrl":"10.14814/phy2.70134","url":null,"abstract":"<p><p>Knowledge of muscle contractile properties, physical fitness, and their associations with perceived fatigue may provide insights into mechanisms inducing fatigue and treatment targets. We aimed to identify differences in contractile properties and physical fitness between populations, and examine associations with perceived fatigue. We pooled data on perceived fatigue, physical fitness, and contractile properties from six studies, including a control group (n = 90), cancer survivors (n = 27), patients with chronic obstructive pulmonary disease (COPD; n = 16), chronic myeloid leukemia (CML; n = 20), and statin users (n = 64). We evaluated differences between populations, and associations of contractile properties and physical fitness with perceived fatigue. Compared with the control group, we found differences in contractile properties of patients with COPD (larger muscle force decline: β = -10.5%, 95% CI = -16.7; -4.2, increase in early relaxation time (Rt): β = 84.4%, 95% CI = 51.7; 117.0, increase in half Rt: β = 83.1%, 95% CI = 45.5; 120.7, muscle force rise (MFR): β = 0.2%/ms, 95% CI = 0.1; 0.3, and decrease in MFR: β = -24.3%, 95% CI = -35.7; -13.0) and statin users (early Rt: β = -5.4 ms, 95% CI = -10.0; -0.8, increase in early Rt: β = 19.8%, 95% CI = 2.5; 37.1). Associations between contractile properties and perceived fatigue varied across populations. Longer relaxation times were associated with higher perceived fatigue in hemato-oncological populations. To conclude, contractile properties were impaired in patients with COPD and statin users. Associations between contractile properties and perceived fatigue varied across populations. In hemato-oncological populations, impaired muscle relaxation was associated with higher perceived fatigue.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"12 23","pages":"e70134"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoupling of muscle-tendon unit and fascicle velocity contributes to the in vivo stretch-shortening cycle effect in the male human triceps surae muscle. 肌肉-肌腱单元和肌束速度的解耦有助于男性三头肌表面肌的体内拉伸-缩短循环效应。
IF 2.2
Physiological Reports Pub Date : 2024-12-01 DOI: 10.14814/phy2.70131
Denis Holzer, Daniel Hahn, Ansgar Schwirtz, Tobias Siebert, Wolfgang Seiberl
{"title":"Decoupling of muscle-tendon unit and fascicle velocity contributes to the in vivo stretch-shortening cycle effect in the male human triceps surae muscle.","authors":"Denis Holzer, Daniel Hahn, Ansgar Schwirtz, Tobias Siebert, Wolfgang Seiberl","doi":"10.14814/phy2.70131","DOIUrl":"10.14814/phy2.70131","url":null,"abstract":"<p><p>During the shortening of stretch-shortening cycles (SSCs), muscle force output is enhanced compared with pure shortening (SHO), referred to as the SSC-effect. In general, muscle-tendon unit (MTU), muscle belly, muscle fascicle, and tendon length changes can be decoupled during contraction, which affects force generation and elastic recoil. We researched whether MTU decoupling contributes to the SSC-effect. Participants performed electrically stimulated submaximal fixed-end, SSC, and SHO plantar-flexions on a dynamometer at two velocities (40, 120°/s) and two ranges of motion (15, 25°). Fascicle and tendon length changes of the gastrocnemius medialis, and ankle joint kinematics were assessed by ultrasound and motion capture, respectively. During SSC shortening, ankle joint torque and work, MTU force and work, and fascicle force were increased by 12%-22% compared with SHO, confirming a SSC-effect. Further, fascicle length change and velocity during SSCs were significantly reduced compared with SHO condition, and SSC fascicle work was decreased by ~35%. Our results indicate that MTU decoupling leads to a reduction in fascicle shortening amplitude and velocity, thereby increasing the muscle's force capacity while reducing its work output during SSC shortening. MTU decoupling therefore contributes to the SSC-effect and underlines the limited transferability of joint work measurements to estimated muscle work.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"12 23","pages":"e70131"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing eccentric contraction duration enhances resistance exercise-induced inhibitory control improvement while reducing the exertion perception: A pilot study in young men. 增加偏心收缩持续时间增强阻力运动诱导的抑制控制改善,同时降低运动知觉:一项针对年轻男性的初步研究。
IF 2.2
Physiological Reports Pub Date : 2024-12-01 DOI: 10.14814/phy2.70103
Kento Dora, Takeshi Hashimoto, I Wayan Yuuki, Su Yang, Kousei Tachi, Kaito Hashimoto, Shumpei Fujie, Motoyuki Iemitsu, Shigehiko Ogoh
{"title":"Increasing eccentric contraction duration enhances resistance exercise-induced inhibitory control improvement while reducing the exertion perception: A pilot study in young men.","authors":"Kento Dora, Takeshi Hashimoto, I Wayan Yuuki, Su Yang, Kousei Tachi, Kaito Hashimoto, Shumpei Fujie, Motoyuki Iemitsu, Shigehiko Ogoh","doi":"10.14814/phy2.70103","DOIUrl":"10.14814/phy2.70103","url":null,"abstract":"<p><p>Low-intensity resistance exercise with slow movement and tonic force generation (LRST) effectively improves cognitive inhibitory control (IC) while heightening the subjective perception, which is a barrier to exercise adherence. Compared with concentric (CON) contractions, eccentric (ECC) contractions have greater brain activation related to cognitive functions while decreasing subjective perception. Therefore, we examined whether LRST with a longer duration of ECC contraction (ECC-LRST) could further enhance exercise-induced IC improvement while reducing the subjective perception, compared with traditional LRST. Fourteen healthy, young males performed both ECC-LRST and LRST, with 30% of their one-repetition maximum. The subjective perceptions of exertion and pain associated with exercise were assessed. IC was evaluated at baseline, immediately post-exercise, and 15-min post-exercise. IC improved immediately after both ECC-LRST and LRST (both Ps < 0.05). However, the improvement in IC persisted until 15 min post-exercise for ECC-LRST compared with baseline (p = 0.031) but not for LRST, which showed a significantly smaller improvement than ECC-LRST (p = 0.042). A lower perceived pain (p = 0.039) and a trend toward a lower perceived exertion (p = 0.078) were observed during ECC-LRST than during LRST. ECC-LRST is an effective resistance exercise protocol for improving IC while reducing the perception of exertion.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"12 23","pages":"e70103"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impressions on European physiology education and research-A quick view from the Portuguese experience. 对欧洲生理学教育与研究的印象——从葡萄牙的经验看。
IF 2.2
Physiological Reports Pub Date : 2024-12-01 DOI: 10.14814/phy2.70148
Luís Monteiro Rodrigues
{"title":"Impressions on European physiology education and research-A quick view from the Portuguese experience.","authors":"Luís Monteiro Rodrigues","doi":"10.14814/phy2.70148","DOIUrl":"10.14814/phy2.70148","url":null,"abstract":"<p><p>The Bologna Process and the European Higher Education Area (EHEA) are celebrating 25 years of free mobility and career opportunities. Despite its progress, disparities exist in the effectiveness of this initiative across EHEA countries. Physiology is a mandatory component of health science curricula but lacks standardized educational benchmarks, leading to limited societal awareness and professional opportunities. In contrast, there is a different dynamic in the USA, where physiology is a profession with growing opportunities. Within Europe, national scientific societies are actively promoting physiology education and research but societal awareness and physiology related knowledge and opportunities are still limited. A recent study on the Portuguese reality revealed that while physiology is taught at many institutions, there is significant variability in hands-on training between universities and technical colleges. Notably, only a small percentage of faculty have published in physiology journals, suggesting a diluted identity for the discipline. Challenges in harmonization and training reflect a need for stronger collaboration among scientific organizations to improve physiology teaching and research across Europe. By addressing these issues, the future of physiology can be strengthened, ensuring better recognition and professional development for physiologists in the EHEA.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"12 24","pages":"e70148"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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