Pediatric Investigation最新文献_第4页

Dwell time and bloodstream infection incidence of umbilical venous catheterization in China 中国脐静脉置管停留时间与血流感染发生率

4区医学

Pediatric Investigation Pub Date : 2023-10-15 DOI: 10.1002/ped4.12403

Xu Zheng, Dan He, Zixin Yang, Lu Chen, Min Jiang, Yujie Qi, Fei Qin, Jie Yu, Yaguang Peng, Ling Liu, Mingyan Hei

{"title":"Dwell time and bloodstream infection incidence of umbilical venous catheterization in China","authors":"Xu Zheng, Dan He, Zixin Yang, Lu Chen, Min Jiang, Yujie Qi, Fei Qin, Jie Yu, Yaguang Peng, Ling Liu, Mingyan Hei","doi":"10.1002/ped4.12403","DOIUrl":"https://doi.org/10.1002/ped4.12403","url":null,"abstract":"ABSTRACT Importance Central line‐associated bloodstream infection (CLABSI) is one of the most serious complications of central venous access devices. Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long‐term prognosis. Objective To determine the dwell time and incidence of CLABSI of umbilical venous catheterization (UVC) for preterm infants in China. Methods Preterm infants with UVC admitted to 44 tertiary neonatal intensive care units in 24 provinces in China were enrolled. Study period was from November 2019 to August 2021. The end point of observations was 48 h after umbilical venous (UV) catheter removal. The primary outcomes were dwell time of UV catheter and UVC‐associated CLABSI. Data between infants with UV catheter dwell time ≤7 days and >7 days, and with birth weight (BW) ≤1000 g and >1000 g were compared. Results In total, 2172 neonates were enrolled (gestational age 30.0 ± 2.4 weeks, BW 1258.5 ± 392.8 g). The median UV catheter dwell time was 7 (6–10) days. The incidence of UVC‐associated CLABSI was 3.03/1000 UV catheter days. For infants with UV catheter dwell time ≤7 days and >7 days, the UVC‐associated CLABSI incidence was 3.71 and 2.65 per 1000 UV catheter days, respectively, P = 0.23. For infants with UVC dwell times of 3–6, 7–12, and 13–15 days, the UVC‐associated CLABSI rates were 0.14%, 0.68%, and 2.48% ( P < 0.01). The Kaplan–Meier plot of UV catheter dwell time to CLABSI showed no difference between infants with BW ≤1000 g and >1000 g ( P = 0.60). Interpretation The median dwell time of UV catheter was 7 days, and the incidence of UVC‐associated CLABSI was 3.03/1000 catheter days in China. The daily risk of UVC‐associated CLABSI and other complications increased with the dwell time.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136185286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of removal of ProSeal laryngeal mask airway in children in the supine versus lateral position in a deep plane of anesthesia: A randomized controlled trial 深平面麻醉下儿童仰卧位与侧卧位去除ProSeal喉罩气道的安全性:一项随机对照试验

4区医学

Pediatric Investigation Pub Date : 2023-09-26 DOI: 10.1002/ped4.12401

Shweta Dhiman, Anju R. Bhalotra, Kavita R. Sharma

{"title":"Safety of removal of ProSeal laryngeal mask airway in children in the supine versus lateral position in a deep plane of anesthesia: A randomized controlled trial","authors":"Shweta Dhiman, Anju R. Bhalotra, Kavita R. Sharma","doi":"10.1002/ped4.12401","DOIUrl":"https://doi.org/10.1002/ped4.12401","url":null,"abstract":"ABSTRACT Importance When a ProSeal laryngeal mask airway (PLMA) is removed with the child in a deep plane of anesthesia, the upper airway muscle tone and protective upper airway reflexes may be obtunded. Objective To determine whether the supine or lateral position is safer for the removal of a PLMA in deeply anesthetized children by comparing the incidence of upper airway complications. Methods This randomized single‐blind comparative trial was conducted at a tertiary care hospital between January 2020 and September 2020. Forty children of the American Society of Anesthesiologists class I/II of ages 1–12 years age undergoing surgery under general anesthesia with PLMA used as the definitive airway device were recruited. Patients were randomly allocated to lateral group or supine group for PLMA removal in a deep plane of anesthesia in the lateral or supine position. The primary outcome was the number of patients experiencing one or more upper airway complications and the secondary outcomes were incidence of individual respiratory adverse effects and of severe airway complications. Results The incidence of airway complications was 30% in the supine group and 20% in the lateral group ( P = 0.6641). Incidence of laryngospasm, immediate stridor, and excessive secretions were similar. Early stridor and oxygen desaturation were higher in the supine group ( P = 0.0374, P = 0.0183 respectively). Interpretation The overall incidence of upper airway complications was similar with the removal of a PLMA in the supine or lateral position in deeply anesthetized children. The incidence of oxygen desaturation and stridor were higher with PLMA removal in the supine as compared to the lateral position.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologics and oral small-molecule inhibitors for treatment of pediatric atopic dermatitis: Opportunities and challenges. 生物制品和口服小分子抑制剂治疗儿童特应性皮炎：机遇和挑战。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-09-14 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12400

Anqi Zhao, Chaolan Pan, Ming Li

引用次数: 0

A case of familial incontinentia pigmenti in infancy without hyperpigmented stage. 一例婴儿期无色素沉着期的家族性色素失禁。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-09-04 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12399

Yumeng Wang, Xinyi Wang, Ting Chen, Chaolan Pan, Ming Li

引用次数: 0

The update of treatment strategies in pediatrics with generalized pustular psoriasis in China. 中国儿科泛发性脓疱性银屑病治疗策略的更新。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-08-31 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12395

Yunliu Chen, Xin Xiang, Zhaoyang Wang, Chaoyang Miao, Zigang Xu

引用次数: 0

Rapid response with good toleration of sirolimus for life-threatening neonatal lymphatic malformations. 西罗莫司对危及生命的新生儿淋巴管畸形反应迅速，耐受性良好。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-08-30 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12397

Shixiao Dong, Li Li, Jiaosheng Xu, Zhonglong Han, Xia Zheng

引用次数: 0

Frequent detection of genetic aberrations reveals novel pathogenesis and treatment modalities in systemic juvenile xanthogranuloma. 对遗传畸变的频繁检测揭示了系统性青少年黄色肉芽肿的新发病机制和治疗模式。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-08-28 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12398

Jiaosheng Xu, Hongyan Ma, Xingfeng Yao, Xiaofeng Han, Yang Wen, Siwei Wang, Zigang Xu, Lin Ma

引用次数: 0

Rare case of secondary hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis. 播散性组织胞浆菌病患者继发性噬血细胞性淋巴组织细胞增多症的罕见病例。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-08-09 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12392

Hatem Alzahrani, Melanie Pancoast, Kody Finstad, Nicole Pele, Francisca Fasipe, Mohamed Elsaid

引用次数: 0

Clinical and genetic findings in 13 Chinese children with keratinopathic ichthyosis. 13例中国儿童角化性鱼鳞病的临床和遗传学研究。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-07-15 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12391

Zhou Yang, Zhe Xu, Rui He, Xin Xiang, Bin Zhang, Lin Ma

{"title":"Clinical and genetic findings in 13 Chinese children with keratinopathic ichthyosis.","authors":"Zhou Yang, Zhe Xu, Rui He, Xin Xiang, Bin Zhang, Lin Ma","doi":"10.1002/ped4.12391","DOIUrl":"10.1002/ped4.12391","url":null,"abstract":"Importance: Keratinopathic ichthyosis (KPI) represents a group of predominantly autosomal dominant genodermatoses resulting from mutations in the KRT1, KRT2, or KRT10 genes. In KPI, the relationship between genotype and phenotype is complex.Objective: To analyze the clinical manifestations and gene mutations in Chinese patients with KPI.Methods: Clinical data were collected from 13 children diagnosed with KPI, and peripheral blood DNA samples were extracted from both the patients and their parents Next-generation sequencing was performed using a congenital ichthyosis multi-gene panel, and the selected variants in the patients and their parents were further validated using the Sanger sequencing method.Results: Genetic analysis identified missense mutations in either KRT1 or KRT10 in ten patients exhibiting varying degrees of severity and distinct features of epidermolytic ichthyosis. A missense hotspot mutation in KRT2 was identified in one patient with superficial epidermolytic ichthyosis. Additionally, two truncation mutations in KRT10 were detected, leading to the development of generalized ichthyosiform erythroderma. Ear malformation and ectropion at birth, scalp involvement, and palmoplantar hyperkeratosis were observed as early signs of ichthyosis with confetti.Interpretation: We analyzed the genotype-phenotype correlations in KPI, revealing that the types and locations of different mutations are associated with distinct phenotypic characteristics. Oral acitretin could be considered a treatment option for severe patients at an appropriate dosage and timing.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 3","pages":"168-176"},"PeriodicalIF":1.9,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/3f/PED4-7-168.PMC10509410.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of topical gentamicin ointment in the treatment of Nagashima-type palmoplantar keratosis in children with a nonsense mutation. 应用庆大霉素软膏治疗无义突变儿童Nagashima型掌跖角化病。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-06-28 eCollection Date: 2023-09-01 DOI: 10.1002/ped4.12389

Shan Wang, Zhou Yang, Ying Liu, Huan Zhang, Zongyang Liu, Xiaoling Wang, Ying Li, Haihong Liu, Yonghong Yang, Lin Ma

{"title":"Application of topical gentamicin ointment in the treatment of Nagashima-type palmoplantar keratosis in children with a nonsense mutation.","authors":"Shan Wang, Zhou Yang, Ying Liu, Huan Zhang, Zongyang Liu, Xiaoling Wang, Ying Li, Haihong Liu, Yonghong Yang, Lin Ma","doi":"10.1002/ped4.12389","DOIUrl":"10.1002/ped4.12389","url":null,"abstract":"Importance: Nagashima-type palmoplantar keratosis (NPPK) is a hereditary dermatosis mostly caused by a nonsense mutation in SERPINB7. Despite the increasing interest in readthrough gentamicin treatment of NPPK, clinical evidence for this treatment is limited.Objective: This study aimed to provide further evidence for the use of topical gentamicin in the treatment of NPPK in children with nonsense mutations.Methods: We designed a bilaterally controlled study of topical gentamicin ointment. Children diagnosed with NPPK carrying nonsense mutations were enrolled in this study. A 0.1% gentamicin ointment was applied to one hand and an emollient to the other for 3 months. A bilateral comparison of the visual analog scale scores for clinical manifestations and safety was performed.Results: Ten children with NPPK were included in this study. In comparison with the emollient side, the topical gentamicin side showed significant improvements in hyperkeratosis, erythema, maceration, and desquamation after 1 and 3 months of treatment (P < 0.05). However, hyperhidrosis and odor did not improve significantly. No adverse events were observed during the systemic safety monitoring examinations.Interpretation: Topical gentamicin ointment showed good safety in the treatment of NPPK with nonsense mutations, indicating that it is a promising therapeutic choice in children with NPPK.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 3","pages":"163-167"},"PeriodicalIF":1.9,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/2d/PED4-7-163.PMC10509405.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41146108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0