Pediatric Investigation最新文献

{"title":"Outcomes of complete surgical repair versus palliative intervention in neonates with Tetralogy of Fallot.","authors":"Mohammed Hamzah, Hasan F Othman, Krystel Chedid, Mohammed Alsabri, Ibrahim Qattea, Hany Aly","doi":"10.1002/ped4.12348","DOIUrl":"10.1002/ped4.12348","url":null,"abstract":"<p><p>Using the US National Inpatient Sample dataset (2010 to 2018), we compared outcomes of neonates with Tetralogy of Fallot who had early primary surgical repair (1726 neonate) and those who had staged palliative intervention with transcatheter (1702 neonate) or surgical palliative shunt (2661 neonate).</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/ff/PED4-6-260.PMC9789930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rett syndrome with atrial tachycardia in a girl.","authors":"Juanli Wang, Duan Wang, Yanni Chen, Huan Li, Yanmin Zhang, Yue Wu","doi":"10.1002/ped4.12346","DOIUrl":"10.1002/ped4.12346","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/38/PED4-6-302.PMC9789929.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10446269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diversity of clinical manifestations of human monkeypox should be emphasized in practice.","authors":"Kaihu Yao","doi":"10.1002/ped4.12349","DOIUrl":"10.1002/ped4.12349","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/25/PED4-6-224.PMC9523799.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memory of Professor Pierluigi Cecchi.","authors":"Bo Hu, Xiaoying Nie","doi":"10.1002/ped4.12347","DOIUrl":"10.1002/ped4.12347","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/22/PED4-6-231.PMC9523804.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Staphylococcus lugdunensis</i> in children: A retrospective analysis.","authors":"Thomas Patrick Bowman, Ashutosh Deshpande, Alison Balfour, Kathleen Harvey-Wood","doi":"10.1002/ped4.12345","DOIUrl":"10.1002/ped4.12345","url":null,"abstract":"<p><strong>Importance: </strong><i>Staphylococcus lugdunensis</i> (<i>S. lugdunensis</i>) is a coagulase-negative staphylococcus (CoNS), found commonly as skin flora in humans. While most species of CoNS are clinically benign, <i>S. lugdunensis</i> can exhibit a similar virulence to that of <i>S. aureus</i>. However, there is scant data concerning <i>S. lugdunensis</i> infection in the pediatric population.</p><p><strong>Objective: </strong>To ascertain local <i>S. lugdunensis</i> infection rates and sensitivity patterns in the pediatric population.</p><p><strong>Methods: </strong>A retrospective analysis was undertaken of all <i>S. lugdunensis</i> isolates across a 6-year period from 2015 to 2020. Data were collected from electronic patient notes and laboratory records. Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.</p><p><strong>Results: </strong>Ninety-six isolates of <i>S. lugdunensis</i> were identified from 86 patients. Of these, 34 isolates were treated as an infection. Twenty-three (67.6%) were found to have skin as the primary source of infection. While the observed number was small, central nervous system (CNS) sources of <i>S. lugdunensis</i> infection appear to be a significant source: all three isolates cultured from cerebrospinal fluid were clinically managed as infection. All three were associated with ventriculoperitoneal (VP) shunt infection. No cases of <i>S. lugdunensis</i> infective endocarditis were identified. About 18.6% of <i>S. lugdunensis</i> isolates were resistant to flucloxacillin.</p><p><strong>Interpretation: </strong><i>S. lugdunensis</i> is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection, particularly when associated with VP shunts. Flucloxacillin is recommended locally as the first choice of antibiotic.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/f6/PED4-6-163.PMC9523813.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteremia tuberculosis among HIV-negative children in China.","authors":"Ping Chu, Jin Shi, Fang Dong, Hui Yang, Shunying Zhao, Gang Liu, Huyong Zheng, Jinrong Liu, Huimin Li, Jie Lu","doi":"10.1002/ped4.12342","DOIUrl":"10.1002/ped4.12342","url":null,"abstract":"<p><strong>Importance: </strong>Bacteremia tuberculosis (TB) is a severe form of extrapulmonary TB. Studies assessing bacteremia TB in children are limited, especially for HIV-negative children.</p><p><strong>Objective: </strong>To explore the detailed clinical features of the bacteremia TB in children under 18 years of age.</p><p><strong>Methods: </strong>We reviewed the clinical records of the patients retrospectively and collected the strains isolated from their blood cultures. We used mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) to characterize the bacterial genotypes and alamarBlue to determine their drug susceptibility profiles. Polymerase chain reactions and DNA sequencing were used to identify drug-resistant mutations.</p><p><strong>Results: </strong>There were 13 pediatric bacteremia TB patients, 10 of whom were diagnosed with Bacillus Calmette-Guérin (BCG) bacteremia TB. Thirteen patients aged from 0.30 to 11.58 years were enrolled, of whom 76.92% were boys. All had fevers before hospitalization, and 76.92% had respiratory symptoms. All had received BCG vaccinations, and 46.15% had adverse post-vaccination reactions. Compared with <i>Mycobacterium tuberculosis</i>, BCG bacteremia was more likely to appear in younger children. Patients with BCG bacteremia had primary immunodeficiency diseases, and lower CD4, IgA, and IgE levels.</p><p><strong>Interpretation: </strong>Bacteremia TB was rapidly fatal in a large proportion of the immunodeficient children. Because classic findings may not be diagnostically specific, a high level of clinical suspicion is required, especially for patients with certain types of immunosuppression. Studies are needed to develop rapid diagnostic tests and to determine the value of empirical therapy in childhood bacteremia TB.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/f9/PED4-6-197.PMC9523815.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33492386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instruction for Authors.","authors":"Support Editor","doi":"10.12777/ijse.3.2.39-40","DOIUrl":"https://doi.org/10.12777/ijse.3.2.39-40","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73225533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for early-onset neonatal sepsis on the Kaiser Permanente sepsis risk calculator could reduce neonatal antibiotic usage by two-thirds.","authors":"Michelle Fernandes, Lucinda Winckworth, Lyrille Lee, Madiha Akram, Simon Struthers","doi":"10.1002/ped4.12344","DOIUrl":"10.1002/ped4.12344","url":null,"abstract":"<p><strong>Importance: </strong>Effective screening strategies for early-onset neonatal sepsis (EONS) have the potential to reduce high volume parenteral antibiotics (PAb) usage in neonates.</p><p><strong>Objective: </strong>To compare management decisions for EONS, between CG149 National Institute for Health and Care Excellence (NICE) guidelines and those projected through the virtual application of the Kaiser Permanente sepsis risk calculator (SRC) in a level 2 neonatal unit at a district general hospital (DGH).</p><p><strong>Methods: </strong>Hospital records were reviewed for maternal and neonatal risk factors for EONS, neonatal clinical examination findings, and microbial culture results for all neonates born at ≥34 weeks' gestation between February and July 2019, who were (1) managed according to CG149-NICE guidelines or (2) received PAb within 72 h following birth at a DGH in Winchester, UK. SRC projections were obtained using its virtual risk estimator.</p><p><strong>Results: </strong>Sixty infants received PAb within the first 72 h of birth during the study period. Of these, 19 (31.7%) met SRC criteria for antibiotics; 20 (33.3%) met the criteria for enhanced observations and none had culture-proven sepsis. Based on SRC projections, neonates with '≥1 NICE clinical indicator and ≥1 risk factor' were most likely to have a sepsis risk score (SRS) >3. Birth below 37 weeks' gestation (risk ratio [RR] = 2.31, 95% confidence interval [CI]: 1.02-5.22) and prolonged rupture of membranes (RR = 3.14, 95% CI: 1.16-8.48) increased the risk of an SRS >3.</p><p><strong>Interpretation: </strong>Screening for EONS on the SRC could potentially reduce PAb usage by 68% in term and near-term neonates in level 2 neonatal units.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/09/PED4-6-171.PMC9523803.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10721952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated herpes zoster with mucosal involvement in an immunosuppressed child.","authors":"Chaoyang Miao, Rui He, Bin Zhang","doi":"10.1002/ped4.12338","DOIUrl":"10.1002/ped4.12338","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/80/PED4-6-226.PMC9523814.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An international study on implementation and facilitators and barriers for parent-infant closeness in neonatal units.","authors":"Nicole R van Veenendaal, Nanon H M Labrie, Silke Mader, Anne A M W van Kempen, Sophie R D van der Schoor, Johannes B van Goudoever","doi":"10.1002/ped4.12339","DOIUrl":"10.1002/ped4.12339","url":null,"abstract":"<p><strong>Importance: </strong>Parent-infant closeness and active parent participation in neonatal care are important for parent and infant health.</p><p><strong>Objective: </strong>To give an overview of current neonatal settings and gain an in-depth understanding of facilitators and barriers to parent-infant closeness, zero-separation, in 19 countries.</p><p><strong>Methods: </strong>Neonatal intensive care unit (NICU) professionals, representing 45 NICUs from a range of geographic regions in Europe and Canada, were purposefully selected and interviewed June-December 2018. Thematic analysis was conducted to identify, analyze and report patterns (themes) for parent-infant closeness across the entire series of interviews.</p><p><strong>Results: </strong>Parent-infant separation during infant and/or maternity care is very common (42/45 units, 93%), despite the implementation of family integrated care (FICare) practices, including parent participation in medical rounds (17/45, 38%), structured education sessions for parents (16/45, 36%) and structured training for healthcare professionals (22/45, 49%). NICU professionals encountered four main themes with facilitators and barriers for parent-infant closeness on and between the hospital, unit, staff, and family level: <i>Culture</i> (jointly held characteristics, values, thinking and behaviors about parental presence and participation in the unit), <i>Collaboration</i> (the act of working together between and within different levels), <i>Capacities</i> (resources and policies), and <i>Coaching</i> (education to acquire and transfer knowledge and skills).</p><p><strong>Interpretation: </strong>Implementing parent-infant closeness in the NICU is still challenging for healthcare professionals. Further optimization in neonatal care towards zero-separation and parent-infant closeness can be achieved by enforcing the 'four Cs for Closeness': <i>Culture, Collaboration, Capacities</i>, and <i>Coaching</i>.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/24/PED4-6-179.PMC9523817.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}