Pediatric Investigation最新文献_第10页

Upregulation of cadherin-11 contributes to cholestatic liver fibrosis. Cadherin-11的上调导致胆汁淤积性肝纤维化。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-03-22 eCollection Date: 2022-06-01 DOI: 10.1002/ped4.12317

Bo Wu, Xinbei Tian, Weipeng Wang, Jing Zhu, Ying Lu, Jun Du, Yongtao Xiao

{"title":"Upregulation of cadherin-11 contributes to cholestatic liver fibrosis.","authors":"Bo Wu, Xinbei Tian, Weipeng Wang, Jing Zhu, Ying Lu, Jun Du, Yongtao Xiao","doi":"10.1002/ped4.12317","DOIUrl":"10.1002/ped4.12317","url":null,"abstract":"Importance: Cadherin-11 (CDH11), a cell-to-cell adhesion molecule, is implicated in the fibrotic process of several organs. Biliary atresia (BA) is a common cholestatic liver disease featuring cholestasis and progressive liver fibrosis in children. Cholestatic liver fibrosis may progress to liver cirrhosis and lacks effective therapeutic strategies. Currently, the role of CDH11 in cholestatic liver fibrosis remains unclear.Objective: This study aimed to explore the functions of CDH11 in cholestatic liver fibrosis.Methods: The expression of CDH11 in BA livers was evaluated by database analysis and immunostaining. Seven BA liver samples were used for immunostaining. The wild type (Wt) and CDH11 knockout (CDH11-/- ) mice were subjected to bile duct ligation (BDL) to induce cholestatic liver fibrosis. The serum biochemical analysis, liver histology, and western blotting were used to assess the extent of liver injury and fibrosis as well as activation of transforming growth factor-β (TGF-β)/Smad pathway. The effect of CDH11 on the activation of hepatic stellate cell line LX-2 cells was investigated.Results: Analysis of public RNA-seq datasets showed that CDH11 expression levels were significantly increased in livers of BA, and CDH11 was correlated with liver fibrosis in BA. BDL-induced liver injury and liver fibrosis were attenuated in CDH11-/- mice compared to Wt mice. The protein expression levels of phosphorylated Smad2/3 were decreased in livers of CDH11-/- BDL mice compared to Wt BDL mice. CDH11 knockdown inhibited the activation of LX-2 cells.Interpretation: CDH11 plays an important role in cholestatic liver fibrosis and may represent a potential therapeutic target for cholestatic liver disease, such as BA.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"6 2","pages":"100-110"},"PeriodicalIF":1.9,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/27/PED4-6-100.PMC9218970.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient adaptation of high-quality international guidelines for Chinese children with primary immune thrombocytopenia. 为中国儿童原发性免疫血小板减少症患者有效调整高质量的国际指南。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-03-21 eCollection Date: 2022-06-01 DOI: 10.1002/ped4.12313

Yali Liu, Runhui Wu

引用次数: 0

Adapted guideline for the diagnosis and treatment of primary immune thrombocytopenia for Chinese children (2021). 中国儿童原发性免疫性血小板减少症诊断和治疗指南（2021 年）》。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-02-21 eCollection Date: 2022-06-01 DOI: 10.1002/ped4.12305

引用次数: 0

Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition. 接受全肠外营养的日本小学生回避型/限制型食物摄入障碍的特征和结果。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-12-13 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12293

Akira Tamura, Koichi Minami, Yuko Tsuda, Hiroshi Tsujimoto, Takayuki Ichikawa, Kazuhiro Mizumoto, Hiroyuki Suzuki

{"title":"Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition.","authors":"Akira Tamura, Koichi Minami, Yuko Tsuda, Hiroshi Tsujimoto, Takayuki Ichikawa, Kazuhiro Mizumoto, Hiroyuki Suzuki","doi":"10.1002/ped4.12293","DOIUrl":"10.1002/ped4.12293","url":null,"abstract":"The clinical outcomes of adolescents with avoidant/restrictive food intake disorder (ARFID) remain unclear. Furthermore, no report has compared the characteristics of ARFID and restricting-type anorexia nervosa (R-AN) in elementary-school students on total parenteral nutrition (TPN). This study retrospectively reviewed inpatients diagnosed with ARFID or R-AN between 2005 and 2019. Patients with ARFID (two boys and seven girls) and R-AN (13 girls) were hospitalized because of rapid physical deterioration, and nutrition therapy was continued without withdrawal. The ARFID group exhibited significantly lower body weights at admission than the R-AN group and gained an average of 6.5 kg during hospitalization; furthermore, the monthly weight gain during hospitalization was significantly higher, and no relapse was observed. Early physical improvement in ARFID resulted in good recovery. In conclusion, TPN can be easily introduced to patients with ARFID, in whom aversive eating is a concern, and is a suitable treatment for ARFID.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"5 4","pages":"293-298"},"PeriodicalIF":2.2,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/7c/PED4-5-293.PMC8666945.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral testosterone undecanoate is an effective treatment for micropenis therapy. 口服十一酸睾酮是治疗小阴茎症的有效方法。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-12-13 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12304

Paul Saenger, Margaret Steiner

引用次数: 0

Exploring the efficacy of testosterone undecanoate in male children with 5α-reductase deficiency. 探索十一酸睾酮对 5α 还原酶缺乏症男性儿童的疗效。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-12-13 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12302

Ying Liu, Lijun Fan, Xiaoling Wang, Chunxiu Gong

{"title":"Exploring the efficacy of testosterone undecanoate in male children with 5α-reductase deficiency.","authors":"Ying Liu, Lijun Fan, Xiaoling Wang, Chunxiu Gong","doi":"10.1002/ped4.12302","DOIUrl":"10.1002/ped4.12302","url":null,"abstract":"Importance: Children with 5-alpha-reductase deficiency (5α-RD) and hypospadias present with micropenis, which makes it difficult to obtain sufficient tissue for urethral reconstruction.Objective: We investigated the therapeutic effects of oral testosterone undecanoate and established a standard androgen treatment protocol for patients with 5α-RD with micropenis.Methods: Patients with 5α-RD were treated with oral testosterone undecanoate for 3 months as a course. All patients were treated with no more than 3 courses. If the penile length (PL) reached 2.5 cm (the minimum criterion for surgery) or greater than or equal to -2.5 standard deviations (SDs) (lower limit of normal), testosterone undecanoate was considered to be effective.Results: The median age of 90 patients with 5α-RD was 1.7 years (0.9, 3.1 years). The baseline PL was 1.9 ± 0.6 cm before treatment. At the end of the first course, the PL of 63 patients (70%) reached 2.5 cm, and 49 patients (54%) reached greater than or equal to -2.5 SDs. After two treatment courses, the PL of 81 patients (90%) reached 2.5 cm, and 90 patients (100%) reached greater than or equal to -2.5 SDs. After three courses, the PL of all patients reached 2.5 cm, and all patients reached a PL greater than or equal to -2.5 SDs. No abnormal increase was observed in height-SD score, weight-SD score, or ratio of bone age to chronological age during the 1-3-year follow-up.Interpretation: After 3-9 months of treatment, PL increased to the target length. No severe adverse reactions were observed during follow-up. Testosterone undecanoate was safe and effective in children with 5α-RD with micropenis.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"5 4","pages":"249-254"},"PeriodicalIF":2.2,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/2f/PED4-5-249.PMC8666940.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39749766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of problematic internet use with depression, impulsivity, anger, aggression, and social anxiety: Results of a national study among Lebanese adolescents. 有问题的互联网使用与抑郁、冲动、愤怒、攻击性和社交焦虑之间的关系：一项针对黎巴嫩青少年的全国性研究结果。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-12-13 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12299

Chadia Haddad, Diana Malaeb, Hala Sacre, Jad Bou Khalil, Wael Khansa, Roula Al Hajj, Nelly Kheir, Sylvia Saade, Sahar Obeid, Souheil Hallit

{"title":"Association of problematic internet use with depression, impulsivity, anger, aggression, and social anxiety: Results of a national study among Lebanese adolescents.","authors":"Chadia Haddad, Diana Malaeb, Hala Sacre, Jad Bou Khalil, Wael Khansa, Roula Al Hajj, Nelly Kheir, Sylvia Saade, Sahar Obeid, Souheil Hallit","doi":"10.1002/ped4.12299","DOIUrl":"10.1002/ped4.12299","url":null,"abstract":"Importance: Several studies conducted worldwide (mostly in Western countries) highlighted the negative effects of problematic internet use, particularly among adolescents aged 12 to 17, including depression, impulsivity, aggression, and social fear and avoidance. In Lebanon, literature on the prevalence and impact of problematic internet use among adolescents is limited.Objective: This study aim was to study the association between problematic internet use and depression, impulsivity, anger, aggression and social phobia among Lebanese adolescents.Methods: A cross-sectional study was performed on 1103 young adolescents (14-17 years), recruited from October 2017 till April 2018. The Internet Addiction Test (IAT) was used to evaluate the level of problematic internet use. Data were analyzed using the MANCOVA analysis. The main independent variable of interest was the IAT, while the dependent variables included the psychological scales.Results: The multivariate analysis taking the psychological scales as the dependent variables and the problematic internet use (IAT score) as an independent variable, showed that problematic internet use was associated with higher depression, impulsivity, aggression, anger, hostility and social anxiety.Interpretation: Problematic internet use has become an important health issue that should not be overlooked, particularly because of the increased use of the internet by adolescents. Educational programs on early exposure to the internet should be developed.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"5 4","pages":"255-264"},"PeriodicalIF":2.2,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/60/PED4-5-255.PMC8666947.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39749767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary central nervous system lymphoblastic B cell lymphoma located at cerebellum in a child: A case report and literature review. 位于儿童小脑的原发性中枢神经系统淋巴母细胞 B 细胞淋巴瘤：病例报告和文献综述。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-12-13 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12303

Xueliang Yang, Yanlong Duan, Chunju Zhou, Ling Jin, Ningning Zhang, Shuang Huang, Meng Zhang, Jing Yang, Yonghong Zhang

{"title":"Primary central nervous system lymphoblastic B cell lymphoma located at cerebellum in a child: A case report and literature review.","authors":"Xueliang Yang, Yanlong Duan, Chunju Zhou, Ling Jin, Ningning Zhang, Shuang Huang, Meng Zhang, Jing Yang, Yonghong Zhang","doi":"10.1002/ped4.12303","DOIUrl":"10.1002/ped4.12303","url":null,"abstract":"Introduction: Primary central nervous system lymphoma (PCNSL) is extremely rare in pediatric population. We reported a case of PCNSL in a 3-year-old girl and reviewed the literature in the past three decades.Case presentation: A 3-year-old girl presented with gait disturbance. A contrast-enhanced magnetic resonance image of the brain showed a solitary bulky mass in the left cerebellar hemisphere, hydrocephalus and cerebellar tonsillar hernia. Surgical resection was performed and the patient was diagnosed with primary central nervous system lymphoblastic B cell lymphoma. Then the patient received regular chemotherapy, including 6 cycles of chemotherapy containing high-dose methotrexate (HD-MTX). The patient remains alive 15 months after the diagnosis with no evidence of active disease, but suffered twice chronic subdural hematoma, which was treated by burr hole drainage.Conclusion: Lymphoblastic B cell lymphoma is a rare histologic subtype of pediatric PCNSL. Chemotherapy containing HD-MTX remains the most effective treatment. The patient should avoid head impact after surgical resection of the tumor to prevent chronic subdural hematoma.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"5 4","pages":"318-322"},"PeriodicalIF":2.2,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/40/PED4-5-318.PMC8666934.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent coagulopathy during Streptococcus pneumoniae sepsis and left foot abscess in a previously healthy infant revealed tyrosinemia. 一名先前健康的婴儿在肺炎链球菌败血症和左足脓肿期间出现持续性凝血病，并显示出酪氨酸血症。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-10-24 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12298

Bing Liu, Lingyun Guo, Xue Ning, Gang Liu

引用次数: 0

Severe hypertransaminasemia during mild SARS-CoV-2 infection: A pediatric case report and literature review. 轻度 SARS-CoV-2 感染期间的严重高转氨酶血症：儿科病例报告和文献综述

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2021-10-05 eCollection Date: 2021-12-01 DOI: 10.1002/ped4.12300

Alessandra Palpacelli, Gaia Martelli, Bianca Lattanzi, Alessandro Volpini, Salvatore Cazzato

引用次数: 0