Pediatric Investigation最新文献

筛选
英文 中文
Evaluating anger in Chinese adolescents: Psychometric validation and clinical sensitivity of the Chinese version of the Children's Inventory of Anger. 评估中国青少年的愤怒:中文版儿童愤怒量表的心理测量验证和临床敏感性。
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-10-11 eCollection Date: 2026-04-01 DOI: 10.1002/ped4.70024
Xinyue Zhang, Liping Ma, Chi-Son Kuan, Xinli Chi, Yuan Cao, Suhong Wang, Chao Yan, W Michael Nelson
{"title":"Evaluating anger in Chinese adolescents: Psychometric validation and clinical sensitivity of the Chinese version of the Children's Inventory of Anger.","authors":"Xinyue Zhang, Liping Ma, Chi-Son Kuan, Xinli Chi, Yuan Cao, Suhong Wang, Chao Yan, W Michael Nelson","doi":"10.1002/ped4.70024","DOIUrl":"https://doi.org/10.1002/ped4.70024","url":null,"abstract":"<p><strong>Importance: </strong>Accurately assessing anger in Chinese adolescents is crucial. Uncontrolled anger among adolescents can manifest in externalizing and internalizing problems. However, there are limited assessments specifically designed to measure anger in Chinese adolescents.</p><p><strong>Objective: </strong>This study aimed to evaluate the psychometric properties of the Chinese version of the Children's Inventory of Anger (ChIA-C).</p><p><strong>Methods: </strong>We enrolled 1790 adolescents aged 11-18 years from five middle schools (mean age of 14.56 ± 1.71 years, 57.9% female). Of these, 901 participants (mean age of 13.95 ± 1.66 years, 59.2% female) completed a retest survey after 9 months. Psychometric assessments comprised factor structure analysis, reliability testing, validity examination, and measurement invariance analysis. Furthermore, we recruited 50 pairs of depressed adolescents and healthy controls to evaluate the clinical sensitivity of the ChIA-C.</p><p><strong>Results: </strong>Factor analysis confirmed a robust four-factor structure with favorable fit indices (<i>χ<sup>2</sup>/df</i> = 3.35, Root Mean Square Error of Approximation = 0.05, Comparative Fit Index = 0.92, and Tucker-Lewis Index = 0.91). Internal consistency reliability (Cronbach's α = 0.76-0.92) and test-retest reliability (<i>r</i> = 0.38-0.50, <i>P</i> < 0.001) were satisfactory. Positive correlations between ChIA-C scores and those of the Anger Expression Scale for Children (<i>r</i> = 0.28-0.49, <i>P</i> < 0.001) supported moderate convergent validity. Concurrent and predictive validity were confirmed by significant positive correlations between ChIA-C and Children's Depression Inventory scores at wave one and wave two, respectively (<i>r</i> = 0.13-0.34, <i>P</i> < 0.001). Moreover, measurement invariance across age and partial measurement invariance across sex were supported. Depressed adolescents showed significantly higher scores than healthy controls in the ChIA-C and its authority relationship and physical aggression subscales.</p><p><strong>Interpretation: </strong>The ChIA-C exhibits robust psychometric properties, establishing its reliability and validity as a tool for assessing anger in Chinese adolescents.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"10 2","pages":"147-158"},"PeriodicalIF":2.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 15-year population-based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy. 意大利儿童炎症性肠病发病率和疫苗接种覆盖率的15年人群研究
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-09-18 eCollection Date: 2025-12-01 DOI: 10.1002/ped4.70023
Francesca Fortunato, Angelo Campanozzi, Michele Di Toma, Alessandra Marinari, Domenico Martinelli
{"title":"A 15-year population-based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy.","authors":"Francesca Fortunato, Angelo Campanozzi, Michele Di Toma, Alessandra Marinari, Domenico Martinelli","doi":"10.1002/ped4.70023","DOIUrl":"10.1002/ped4.70023","url":null,"abstract":"<p><strong>Importance: </strong>The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, particularly after the coronavirus disease 2019 pandemic. As children with IBD are at higher risk of infection, adherence to vaccination schedules is essential. However, data on the incidence of IBD and vaccination coverage in Italian children remain limited.</p><p><strong>Objective: </strong>To assess the incidence of IBD in children aged 0-14 years in the Apulia region of Italy (2009-2023) and to evaluate their vaccination coverage for both mandatory and recommended vaccines.</p><p><strong>Methods: </strong>A retrospective population-based study was conducted using hospital discharge records and a user fee exemption registry to identify incident IBD cases. Vaccination history was obtained from the regional immunization system. Age-standardized incidence rates (SIRs) were calculated. Vaccination coverage was assessed based on the receipt of all age-appropriate vaccines according to regional immunization schedules.</p><p><strong>Results: </strong>Between 2009 and 2023, 1044 incident pediatric IBD cases were identified, with an average annual SIR of 12.7/100 000. A significant increase in incidence occurred after 2020 (<i>P</i> < 0.001), peaking in the 10-14 age group. Among the 259 patients assessed for vaccination coverage, the rates were high for hexavalent (100.0%) and pneumococcal vaccines (99.2%), moderate for rotavirus (82.5%) and meningococcal vaccines (79.9%), and lower for human papillomavirus (66.3% in females and 52.1% in males) and diphtheria-tetanus-acellular pertussis and inactivated polio vaccines (dTap-IPV) booster (30.2%). Influenza coverage in 2023/24 was 18.9%. Children with complex chronic conditions had lower uptake of measles, mumps, and rubella and dTap-IPV boosters.</p><p><strong>Interpretation: </strong>The incidence of pediatric IBD is increasing in Apulia, whereas vaccination coverage remains below optimal levels. Targeted strategies are needed to enhance immunization in this vulnerable population.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 4","pages":"383-393"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, regional, and national burden of brain and central nervous system cancer in children and adolescents, 1990-2021: A systematic analysis of the Global Burden of Disease study 2021. 1990-2021年儿童和青少年脑和中枢神经系统癌症的全球、区域和国家负担:2021年全球疾病负担研究的系统分析
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-09-11 eCollection Date: 2025-12-01 DOI: 10.1002/ped4.70018
Yafang Deng, Qiang Gao, Wei Zhang
{"title":"Global, regional, and national burden of brain and central nervous system cancer in children and adolescents, 1990-2021: A systematic analysis of the Global Burden of Disease study 2021.","authors":"Yafang Deng, Qiang Gao, Wei Zhang","doi":"10.1002/ped4.70018","DOIUrl":"10.1002/ped4.70018","url":null,"abstract":"<p><strong>Importance: </strong>Brain and central nervous system (CNS) cancers are the most common pediatric solid tumors, significantly affecting the patients' life expectancy and quality.</p><p><strong>Objective: </strong>To examine the disease burden of brain and CNS cancer in children and adolescents from 1990 to 2021 across various age groups, sexes, and socio-demographic index levels, at the global, regional, and national levels.</p><p><strong>Methods: </strong>Data, including the incidence, mortality, and disability-adjusted life years (DALYs) of brain and CNS cancer in children and adolescents, were obtained from the 2021 Global Burden of Diseases, Injuries, and Risk Factors Study. Temporal trends were evaluated using the Joinpoint regression model. The relationship between disease burden and socioeconomic development, as well as health inequality, was examined.</p><p><strong>Results: </strong>In 2021, the global age-standardized incidence rate of brain and CNS cancers among patients aged 0-20 years was 1.55 per 100 000 population. From 1990 to 2021, the global age-standardized mortality rate (ASMR) declined from 1.14 to 0.76 per 100 000, and the age-standardized DALY rate (ASDR) decreased from 94.29 to 62.79 per 100 000. Over the past three decades, most regions and countries and territories have shown declining trends in ASMR and ASDR. Global inequality of disease burden persists, with regions possessing higher socioeconomic statuses exhibiting lower ASMR, ASDR, and mortality-to-incidence ratio.</p><p><strong>Interpretation: </strong>The decline in ASMR and ASDR of pediatric brain and CNS cancer indicates improvements in disease management and patient outcomes. Enhancing diagnostic and therapeutic strategies, improving life quality, and promoting health equity are crucial directions for future research.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 4","pages":"325-336"},"PeriodicalIF":2.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between dietary preferences and asthma among first-grade primary school children. 小学一年级儿童饮食偏好与哮喘的关系
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-09-04 eCollection Date: 2025-12-01 DOI: 10.1002/ped4.70021
Xinyue Zhang, Xiaosa Wen, Tao Liu, Yongquan Yu, Liujie Zhu, Yingzi Chen, Dan Yu, Su Xu, Zengliang Ruan
{"title":"Association between dietary preferences and asthma among first-grade primary school children.","authors":"Xinyue Zhang, Xiaosa Wen, Tao Liu, Yongquan Yu, Liujie Zhu, Yingzi Chen, Dan Yu, Su Xu, Zengliang Ruan","doi":"10.1002/ped4.70021","DOIUrl":"10.1002/ped4.70021","url":null,"abstract":"<p><strong>Importance: </strong>Asthma is a chronic condition characterized by airway inflammation. Dietary habits have been associated with allergic respiratory disorders, but the specific dietary preferences linked to childhood asthma remain unclear.</p><p><strong>Objective: </strong>To investigate the relationship between dietary preferences and childhood asthma in Minhang District, Shanghai, China.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in 13 sub-districts/towns of Minhang District, Shanghai, in 2014. First-grade primary school students were surveyed during their annual physical examinations. Data on dietary preferences and health status were collected through questionnaires completed by the children's primary caregivers. Logistic regression analysis was used to assess the relationship between dietary preferences and asthma. Stratified analyses were conducted by sex and body mass index groups.</p><p><strong>Results: </strong>A total of 8412 children, with an average age of 6.64 ± 0.29 years, participated in the survey. After adjusting for potential confounders, children who reported a preference for pickled and smoked foods exhibited a significantly elevated risk of asthma (odds ratio [OR] = 1.81; 95% confidence interval [CI]: 1.16-2.82). Subgroup analysis further revealed that girls with a preference for fried foods were at a higher risk of developing asthma (OR = 14.72; 95% CI: 1.89-114.65).</p><p><strong>Interpretation: </strong>Our findings suggest that certain dietary preferences, particularly for pickled and smoked foods, may be significant risk factors for childhood asthma.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 4","pages":"313-324"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The possibly neglected victims: Re-examining the involvement of children in the chikungunya epidemic. 可能被忽视的受害者:重新审视儿童在基孔肯雅热流行病中的参与情况。
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-08-31 eCollection Date: 2025-09-01 DOI: 10.1002/ped4.70022
Ran Wang, Kevin C Kain, Zhengde Xie
{"title":"The possibly neglected victims: Re-examining the involvement of children in the chikungunya epidemic.","authors":"Ran Wang, Kevin C Kain, Zhengde Xie","doi":"10.1002/ped4.70022","DOIUrl":"10.1002/ped4.70022","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 3","pages":"234-240"},"PeriodicalIF":2.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric human immunodeficiency virus infection in the modern era: A systematic review of recent advances and their implications. 儿童人类免疫缺陷病毒感染在现代时代:最近的进展及其意义的系统回顾。
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-08-25 eCollection Date: 2025-12-01 DOI: 10.1002/ped4.70019
Klaudia Nowak, Krzysztof Łupina, Dominika Lorek, Aleksandra Jabłońska, Alicja Radomska, Tymon Choromański, Jakub Janczura
{"title":"Pediatric human immunodeficiency virus infection in the modern era: A systematic review of recent advances and their implications.","authors":"Klaudia Nowak, Krzysztof Łupina, Dominika Lorek, Aleksandra Jabłońska, Alicja Radomska, Tymon Choromański, Jakub Janczura","doi":"10.1002/ped4.70019","DOIUrl":"10.1002/ped4.70019","url":null,"abstract":"<p><strong>Importance: </strong>Pediatric human immunodeficiency virus (HIV) infection continues to pose a significant global health burden, especially in low- and middle-income countries. Despite advances in antiretroviral therapy (ART), children living with HIV face unique clinical, developmental, and systemic challenges.</p><p><strong>Objective: </strong>To systematically review recent developments in pediatric HIV care, with a focus on treatment innovations, complications, and the transition from pediatric to adult care.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted across PubMed, Scopus, EMBASE, and the World Health Organization databases, covering studies published between 2012 and 2025. Inclusion criteria focused on original research, clinical trials, and guidelines addressing pediatric ART, long-acting therapies, prevention strategies, treatment complications, and transitional care.</p><p><strong>Results: </strong>Early ART initiation was associated with improved neurodevelopment and reduced disease progression. Current pediatric ART regimens favor simplified combinations and weight-based dosing, but pharmacokinetic variability, toxicity, and adherence remain concerns. Long-acting injectable therapies, such as cabotegravir/rilpivirine and investigational agents like lenacapavir and islatravir, show promise for adolescents. Prevention of mother-to-child transmission has significantly reduced pediatric HIV incidence, largely through maternal ART and pre-exposure prophylaxis. However, stigma, poor awareness, and healthcare disparities hinder broader impact. Children on lifelong ART face increased risks of metabolic, cardiovascular, renal, and neurocognitive complications. Transitioning to adult care remains a vulnerable period with high rates of treatment disengagement.</p><p><strong>Interpretation: </strong>Advances in pediatric HIV care are substantial but uneven. Continued investment in age-appropriate therapies, psychosocial support, and implementation research is essential to close persistent gaps and ensure equitable, lifelong care for children and adolescents living with HIV.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 4","pages":"394-404"},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical guideline for postoperative nutrition support in neonates with enterostomy (2024). 新生儿肠造口术后营养支持临床指南(2024)。
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-08-01 eCollection Date: 2025-09-01 DOI: 10.1002/ped4.70016
{"title":"Clinical guideline for postoperative nutrition support in neonates with enterostomy (2024).","authors":"","doi":"10.1002/ped4.70016","DOIUrl":"10.1002/ped4.70016","url":null,"abstract":"<p><p>This is an evidence-based guideline for postoperative nutritional management of neonates with enterostomy. There were 10 clinical questions in enteral nutrition management, parenteral nutrition management, and post-discharge follow-up (including the closure of fistula). The Grading of Recommendations Assessment, Development and Evaluation method was used for constructing the recommendations. Domestic and international literature were systematically searched and reviewed. There were 22 recommendations in this guideline.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 3","pages":"221-233"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-dose versus high-dose methylprednisolone for children with severe Mycoplasma pneumoniae pneumonia (MCMP): A randomized controlled trial. 低剂量甲基强的松龙与高剂量甲基强的松龙治疗重症肺炎支原体肺炎(MCMP):一项随机对照试验
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-07-24 eCollection Date: 2025-09-01 DOI: 10.1002/ped4.70014
Baoping Xu, Ling Cao, Yunxiao Shang, Liping Liu, Liwei Gao, Ju Yin, Jun Liu, Ruohua Yan, Bo Peng, Yong Feng, Zhiying Han, Yao Yao, Wenhui Guo, Nan Yang, Jie Chang, Yiqin Song, Hao Wang, Xirong Wu, Xinyu Wang, Ning Chen, Xiaojuan Zhang, He Zhang, Anxia Jiao, Adong Shen, Keqing Zhang, Yan Yang, John S Ji, Xiaoxia Peng, Kunling Shen
{"title":"Low-dose versus high-dose methylprednisolone for children with severe <i>Mycoplasma pneumoniae</i> pneumonia (MCMP): A randomized controlled trial.","authors":"Baoping Xu, Ling Cao, Yunxiao Shang, Liping Liu, Liwei Gao, Ju Yin, Jun Liu, Ruohua Yan, Bo Peng, Yong Feng, Zhiying Han, Yao Yao, Wenhui Guo, Nan Yang, Jie Chang, Yiqin Song, Hao Wang, Xirong Wu, Xinyu Wang, Ning Chen, Xiaojuan Zhang, He Zhang, Anxia Jiao, Adong Shen, Keqing Zhang, Yan Yang, John S Ji, Xiaoxia Peng, Kunling Shen","doi":"10.1002/ped4.70014","DOIUrl":"10.1002/ped4.70014","url":null,"abstract":"<p><strong>Importance: </strong>Although macrolides combined with glucocorticoid therapy have demonstrated efficacy in preventing long-term pulmonary lesions of severe <i>Mycoplasma pneumoniae</i> pneumonia (MPP), evidence regarding glucocorticoid dose is lacking.</p><p><strong>Objective: </strong>To evaluate the effects of low- and high-dose methylprednisolone on the risk of long-term pulmonary lesions for children with severe MPP when combined with azithromycin.</p><p><strong>Methods: </strong>This randomized, parallel-controlled, multicenter clinical trial was conducted in mainland China and enrolled pediatric patients hospitalized with severe MPP. A total of 424 enrolled patients were randomized (allocation ratio of 1:1) to azithromycin combined with either a low-dose [2 mg/(kg·d)] or a high-dose [10 mg/(kg·d)] methylprednisolone treatment for 3 d followed by tapering over 12 d. The primary outcome was the incidence of composite adverse outcomes, including atelectasis, bronchiectasis, or bronchiolitis obliterans 6 months after treatment.</p><p><strong>Results: </strong>A total of 118 (27.8%) developed adverse pulmonary lesions at 6 months after treatment; 66 of 211 (31.3%) in the high-dose methylprednisolone group and 52 of 213 (24.4%) in the low-dose group, respectively. The risk ratio of long-term pulmonary lesions in a high-dose group to those in a low-dose group was 1.28 (95% confidence interval [95% CI]: 0.94-1.75). In addition, the risk of hypertension in the high-dose group (8.1%, 17 of 211) was higher than that in the low-dose group (1.4%, three of 213), with a risk ratio of 5.72 (95% CI: 1.70-19.23).</p><p><strong>Interpretation: </strong>Azithromycin combined with low-dose methylprednisolone demonstrates non-inferior efficacy in reducing pulmonary lesions at 6-month follow-up compared to combined with high-dose methylprednisolone while exhibiting a more favorable safety profile.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 3","pages":"251-261"},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of new European Respiratory Society/American Thoracic Society bronchodilator reversibility interpretation on asthma diagnosis in children. 新的欧洲呼吸学会/美国胸科学会支气管扩张剂可逆性解释对儿童哮喘诊断的影响。
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-07-16 eCollection Date: 2025-09-01 DOI: 10.1002/ped4.70017
Natalie Blyth, Joe Madge, Erol A Gaillard, David K H Lo
{"title":"Impact of new European Respiratory Society/American Thoracic Society bronchodilator reversibility interpretation on asthma diagnosis in children.","authors":"Natalie Blyth, Joe Madge, Erol A Gaillard, David K H Lo","doi":"10.1002/ped4.70017","DOIUrl":"10.1002/ped4.70017","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 3","pages":"300-303"},"PeriodicalIF":2.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific associations between hypertensive disorders in pregnancy and fetal and placental weight. 妊娠期高血压疾病与胎儿和胎盘体重之间的性别特异性关联。
IF 2 4区 医学
Pediatric Investigation Pub Date : 2025-07-11 eCollection Date: 2025-12-01 DOI: 10.1002/ped4.70015
Alexandra R Sitarik, Ganesa Wegienka, Christine C Johnson, Raminder Khangura, Jennifer K Straughen, Andrea E Cassidy-Bushrow
{"title":"Sex-specific associations between hypertensive disorders in pregnancy and fetal and placental weight.","authors":"Alexandra R Sitarik, Ganesa Wegienka, Christine C Johnson, Raminder Khangura, Jennifer K Straughen, Andrea E Cassidy-Bushrow","doi":"10.1002/ped4.70015","DOIUrl":"10.1002/ped4.70015","url":null,"abstract":"<p><strong>Importance: </strong>Hypertensive disorders in pregnancy (HDPs) are common and increase the risk of maternal and fetal morbidity and mortality. HDPs may impact fetal growth; however, sex-specific effects have been understudied.</p><p><strong>Objective: </strong>To examine whether sex-specific differences exist in the association between HDPs and birthweight and placental weight.</p><p><strong>Methods: </strong>A birth cohort based in Detroit, Michigan, was utilized (<i>n</i> = 1258). HDPs and birthweight were abstracted from medical records; placental weight was obtained from placental pathology reports. Linear regression was used to model sex-specific associations, after multiple imputation, confounder adjustment, and inverse probability weighting to account for selection bias.</p><p><strong>Results: </strong>The primary analysis included all pregnancies (<i>n</i> = 853), while the secondary analysis included those sent for placental pathology, reflective of complicated pregnancies (<i>n</i> = 165). In the primary analysis subset, males of mothers with gestational hypertension had birthweight Z-scores that were on average 0.90 standard deviations higher, but this association was not found among females (interaction <i>P</i> = 0.019; male β [95% confidence interval {CI}]: 0.90 [0.28, 1.52]; female β [95% CI]: -0.12 [-0.65, 0.41]). However, in the subset of complicated pregnancies, female mothers with gestational hypertension also had reduced birthweight (interaction <i>P</i> = 0.013; male β [95% CI]: 1.50 [0.15, 2.86]; female β [95% CI]: -1.14 [-2.13, -0.16]). For fetoplacental weight ratio, any HDP was associated with a lower ratio among females only (interaction <i>P</i> = 0.028; male β [95% CI]: -0.04 [-0.71, 0.64]; female β [95% CI]: -0.95 [-1.57, -0.33]).</p><p><strong>Interpretation: </strong>Male fetuses may prioritize growth, whereas females may prioritize placental development when exposed to HDPs.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"9 4","pages":"372-382"},"PeriodicalIF":2.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书