Pharmaceutical Chemistry Journal最新文献_第2页

Long-Acting Hydrogel Eye Drops Composite Sequentially Releases Basic Fibroblast Growth Factor and Carbomer for Synergistic Promotion of the Repair of Corneal Epithelium 长效水凝胶滴眼液复合剂依次释放碱性成纤维细胞生长因子和卡波姆，协同促进角膜上皮的修复

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-18 DOI: 10.1007/s11094-024-03202-1

Wanling Chen, Kaiping Zhang, Chengyuan Zhang

{"title":"Long-Acting Hydrogel Eye Drops Composite Sequentially Releases Basic Fibroblast Growth Factor and Carbomer for Synergistic Promotion of the Repair of Corneal Epithelium","authors":"Wanling Chen, Kaiping Zhang, Chengyuan Zhang","doi":"10.1007/s11094-024-03202-1","DOIUrl":"https://doi.org/10.1007/s11094-024-03202-1","url":null,"abstract":"Corneal epithelial injury is a high-incidence corneal disease. The purpose of this research is to determine how basic fibroblast growth factors affect bFGF and Carbomer (CAR) long-acting hydrogel eye drops regarding the repair of corneal epithelial injury. Liposome hydrogel eye drops containing both bFGF and CAR were prepared by a thin film hydration method (bFGF-CAR-HED). Particle size, potential and transmission electron microscopy were used to characterize the performance. UV was used to calculate the encapsulation rate, drug loading, and in vitro release. The antioxidant capacity was detected by ABTS and FRAP. Safety was evaluated by cell assay. After parallel mechanical corneal epithelium injury in normal mice, the repair of corneal epithelium injury, sensitivity repair and the expression of inflammatory factors in the cornea were detected. bFGF-CAR-HED is a multilayer liposome with good stability with a particle size of 308.4 ± 7.25 nm, and a potential of 36.3 ± 6.27 mV. The encapsulation rate of bFGF in bFGF-CAR-HED was 92.01 ± 1.05%, the encapsulation rate of CAR was 91.94 ± 0.34%, the drug load of bFGF was 18.82 ± 0.35%, and the drug load of CAR was 19.97 ± 0.39%, which showed sustained release function, low cytotoxicity and good antioxidant capacity. Long-acting hydrogel eye drops can strengthen drug application performance and extend the time of drug action, effectively improving bFGF, eye absorbency and the function of CAR, effectively promoting corneal epithelium damage repair and restoring corneal sensitivity, thereby providing better strategies for promoting corneal epithelium damage repair.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"17 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Evaluation of the Neurotropic Activity of New β-Cycloketol Derivatives 合成和评估新的β-环酮醇衍生物的神经刺激活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-17 DOI: 10.1007/s11094-024-03200-3

S. L. Kocharov, H. A. Panosyan, L. S. Mirzoyan, I. M. Nazaryan, R. G. Paronikyan

引用次数: 0

An Update on the Green Synthesis of Benzimidazole Scaffolds as Antifungal Agents 苯并咪唑支架作为抗真菌剂的绿色合成最新进展

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-17 DOI: 10.1007/s11094-024-03210-1

Anchal Tyagi, Monika Chauhan, Sumitra Nain

引用次数: 0

Design, Synthesis, and Cardiotropic Properties of N1-Benzyl-N2-{2-[(2,3,4-Trimethoxybenzyl)Amino]-Ethyl}Ethane-1,2-Diamines N1-苄基-N2-{2-[(2,3,4-三甲氧基苄基)氨基]-乙基}乙烷-1,2-二胺的设计、合成和强心特性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03198-8

G. V. Mokrov, T. Yu. Vorobieva, V. E. Birukova, A. S. Pantileev, E. I. Barchukova, I. B. Tsorin, M. B. Vititnova, A. G. Rebeko, S. A. Kryzhanovskiy, T. A. Gudasheva, V. L. Dorofeev

引用次数: 0

Fullerene C60 Decreases Inflammation, Oxidative Stress and Apoptosis Induced by 7,12-Dimethylbenz[a]Anthracene (DMBA) in Muscle Tissue Via Caspase-3 and NRF-2 Protein Signaling Pathway 富勒烯 C60 通过 Caspase-3 和 NRF-2 蛋白信号通路降低 7,12-二甲基苯并[a]蒽 (DMBA) 在肌肉组织中诱导的炎症、氧化应激和细胞凋亡

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03207-w

Abdullah Aslan, Seda Beyaz, Ozlem Gok, Ibrahim Hanifi Ozercan, Can Ali Agca

{"title":"Fullerene C60 Decreases Inflammation, Oxidative Stress and Apoptosis Induced by 7,12-Dimethylbenz[a]Anthracene (DMBA) in Muscle Tissue Via Caspase-3 and NRF-2 Protein Signaling Pathway","authors":"Abdullah Aslan, Seda Beyaz, Ozlem Gok, Ibrahim Hanifi Ozercan, Can Ali Agca","doi":"10.1007/s11094-024-03207-w","DOIUrl":"https://doi.org/10.1007/s11094-024-03207-w","url":null,"abstract":"Fullerene C60 exhibits potent antioxidant anti-inflammatory activities as well as anticancer activities. In this study using 60 Wistar albino female rats (n = 60, 8 weeks old), they rats were divided into 4 groups, including 15 rats each. The groups were arranged as follows: (i) Control Group: Group fed with standard diet; (ii) C60 Group: C60 (1.7 mg/kg bw, oral gavage); (iii) DMBA (7,12-dimethylbenz[a]anthracene) Group: DMBA (45 mg/kg bw, oral gavage); (iv) C60 and DMBA Group: C60 (1.7 mg/kg bw, oral gavage) and DMBA (45 mg/kg bw, oral gavage) group. DMBA increased the malondialdehyde levels in muscle tissue, while decreasing GSH and CAT levels; however, treatment with fullerene C60 reversed these effects. In addition, the oral administration of fullerene C60 increased caspase-3 and Nrf-2 protein expression and significantly decreased Bcl-2, NF-κB, TNF-α, COX-2 and p38α (MAPK) protein expression in C60 + DMBA compared to the DMBA group. Moreover, histopathological imaging revealed that the oral administration of fullerene C60 decreases inflammatory cells, edema formation, and hydropic degeneration in the muscles. Taken together, the results of the present study indicated that fullerene C60 nanoparticle provides effective protection by preventing muscle tissue damage.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"117 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withanolides of the Aerial Part of Datura stramonium Growing in Uzbekistan and Cytotoxicity of Daturametelin H 生长在乌兹别克斯坦的曼陀罗药用部分的 Withanolides 和 Daturametelin H 的细胞毒性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03212-z

M. M. Makhmudova, B. A. Abdurakhmanov, R. M. Khalilov, I. D. Bobaev, Kh. M. Bobakulov, G. B. Sotimov, N. D. Abdullaev, E. O. Terent’eva

{"title":"Withanolides of the Aerial Part of Datura stramonium Growing in Uzbekistan and Cytotoxicity of Daturametelin H","authors":"M. M. Makhmudova, B. A. Abdurakhmanov, R. M. Khalilov, I. D. Bobaev, Kh. M. Bobakulov, G. B. Sotimov, N. D. Abdullaev, E. O. Terent’eva","doi":"10.1007/s11094-024-03212-z","DOIUrl":"https://doi.org/10.1007/s11094-024-03212-z","url":null,"abstract":"The extract obtained from the aerial part of Datura stramonium by treatment with EtOH (90%) was fractionated with various organic solvents. Use of extraction naphtha produced 0.28% (in percentage of the raw material mass) of the extracted substances; CHCl3, 2.24%; EtOAc, 1.19%; and n-BuOH, 12.43%. Six withanolides such as daturalactone (I), (22R)-7b,27-hydroxy-1-oxowitha-2,5,24-trienolide (II), daturataturin A (III), withastramonolide (IV), (22R)-27-hydroxy-7b-methoxy-1-oxovita-3,5,24-trienolide (V), and daturametelin H (VI) were isolated from the aerial parts of D. stramonium collected in the Fergana Region of Uzbekistan. Their structures were elucidated on the basis of vast data of IR, UV, and NMR spectroscopic studies. The presence of compounds II, III, and V in the aerial parts of D. stramonium growing in Uzbekistan was proven, while compound VI was isolated for the first time from aerial parts of D. stramonium. The cytotoxicity of chemically pure daturametelin H was studied on cancer cell lines such as cervical epithelial carcinoma HeLa, mammary adenocarcinoma HBL-100 (ATCC NTV 124), adenocarcinoma of the larynx HEp-2 (ATCC:CCL-23), and T-lymphoblastic leukemia CCRF-CEM (ATCC:CCL-19). Daturametelin H was found to exhibit pronounced cytotoxicity at a concentration of 100 mM only against T-lymphoblastic leukemia cells in vitro.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"32 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Ethylcellulose-Based Sorbent for Sample Preparation of Multicomponent Drugs Containing Salicylic Acid 使用乙基纤维素吸附剂制备含水杨酸的多组分药物样品

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03215-w

M. N. Kachalkin, A. V. Voronin, V. A. Kurkin

引用次数: 0

Synthesis and Analgesic Activity of 4-(3-Acyl-2-Aryl-4-Hydroxy-5-Oxo-2,5-Dihydro-1H-Pyrrol-1-yl)Benzoic Acids 4-(3-酰基-2-芳基-4-羟基-5-氧代-2,5-二氢-1H-吡咯-1-基)苯甲酸的合成与镇痛活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03199-7

V. L. Gein, D. V. Chalkov, A. V. Romanova, O. V. Bobrovskaya, S. V. Chaschina

引用次数: 0

Spatial Structure and Anti-Inflammatory Activity of 5-N-Arylaminocarbonyl-6-Aryl-4-Methyl-1,2,3,6-Tetrahydropyrimidine-2-Thiones 5-N-Arylaminocarbonyl-6-Aryl-4-Methyl-1,2,3,6-Tetrahydropyrimidine-2-Thiones 的空间结构和抗炎活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-14 DOI: 10.1007/s11094-024-03201-2

N. A. Buzmakova, T. M. Zamaraeva, I. P. Rudakova, M. V. Dmitriev

引用次数: 0

A Beneficial Role of Caffeic Acid on Cardiovascular Complication Associated with Type-1 Diabetes Mellitus in Rats 咖啡酸对 1 型糖尿病大鼠心血管并发症的有益作用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-14 DOI: 10.1007/s11094-024-03197-9

Ezaj Dadubhai, Nidhi N. Chauhan

{"title":"A Beneficial Role of Caffeic Acid on Cardiovascular Complication Associated with Type-1 Diabetes Mellitus in Rats","authors":"Ezaj Dadubhai, Nidhi N. Chauhan","doi":"10.1007/s11094-024-03197-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03197-9","url":null,"abstract":"The present study aimed to study the effect of caffeic acid (CA) on diabetic cardiac complications associated with Type-I diabetes mellitus (DM) in rats. Type-I DM in rats was induced by streptozotocin (STZ) injection once only [45 mg/kg, i.v]. The animals were divided into four groups, and treatment was given for 8 weeks with CA [25 mg/kg, PO and 50 mg/kg, PO] in two specified diabetic groups. After 8 weeks, serum and urine were collected and various serum and urine parameters were estimated. Animals were then sacrificed, and their hearts were removed for estimation of histopathological and oxidative parameters. STZ-induced diabetic rats showed significantly decreased albumin levels and increased MDA, collagen, and decreased activates of SOD and glutathione in their diabetic hearts. In the diabetic control, rats showed significantly increased serum cardiac parameters of CK, CRP, and LDH and also increased serum lipid profile parameters of LDL, cholesterol, and TG. Treatment with CA 25 mg/kg and 50 mg/kg showed significantly decreased CK, CRP, and LDH in diabetic-treated rats and decreased UA. Additionally, significantly decreased MDA, collagen, and increased activities of SOD and GSH were seen in the diabetic-treated rats. Histopathological findings also supported the beneficial effect of CA on the left ventricle of the heart. The present study revealed that the beneficial effects of CA on diabetic cardiovascular complications may be via anti-oxidative and anti-inflammatory actions.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"10 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0