Pharmaceutical Chemistry Journal最新文献_第2页

Use of Ethylcellulose-Based Sorbent for Sample Preparation of Multicomponent Drugs Containing Salicylic Acid 使用乙基纤维素吸附剂制备含水杨酸的多组分药物样品

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03215-w

M. N. Kachalkin, A. V. Voronin, V. A. Kurkin

引用次数: 0

Synthesis and Analgesic Activity of 4-(3-Acyl-2-Aryl-4-Hydroxy-5-Oxo-2,5-Dihydro-1H-Pyrrol-1-yl)Benzoic Acids 4-(3-酰基-2-芳基-4-羟基-5-氧代-2,5-二氢-1H-吡咯-1-基)苯甲酸的合成与镇痛活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI: 10.1007/s11094-024-03199-7

V. L. Gein, D. V. Chalkov, A. V. Romanova, O. V. Bobrovskaya, S. V. Chaschina

引用次数: 0

Spatial Structure and Anti-Inflammatory Activity of 5-N-Arylaminocarbonyl-6-Aryl-4-Methyl-1,2,3,6-Tetrahydropyrimidine-2-Thiones 5-N-Arylaminocarbonyl-6-Aryl-4-Methyl-1,2,3,6-Tetrahydropyrimidine-2-Thiones 的空间结构和抗炎活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-14 DOI: 10.1007/s11094-024-03201-2

N. A. Buzmakova, T. M. Zamaraeva, I. P. Rudakova, M. V. Dmitriev

引用次数: 0

A Beneficial Role of Caffeic Acid on Cardiovascular Complication Associated with Type-1 Diabetes Mellitus in Rats 咖啡酸对 1 型糖尿病大鼠心血管并发症的有益作用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-14 DOI: 10.1007/s11094-024-03197-9

Ezaj Dadubhai, Nidhi N. Chauhan

{"title":"A Beneficial Role of Caffeic Acid on Cardiovascular Complication Associated with Type-1 Diabetes Mellitus in Rats","authors":"Ezaj Dadubhai, Nidhi N. Chauhan","doi":"10.1007/s11094-024-03197-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03197-9","url":null,"abstract":"The present study aimed to study the effect of caffeic acid (CA) on diabetic cardiac complications associated with Type-I diabetes mellitus (DM) in rats. Type-I DM in rats was induced by streptozotocin (STZ) injection once only [45 mg/kg, i.v]. The animals were divided into four groups, and treatment was given for 8 weeks with CA [25 mg/kg, PO and 50 mg/kg, PO] in two specified diabetic groups. After 8 weeks, serum and urine were collected and various serum and urine parameters were estimated. Animals were then sacrificed, and their hearts were removed for estimation of histopathological and oxidative parameters. STZ-induced diabetic rats showed significantly decreased albumin levels and increased MDA, collagen, and decreased activates of SOD and glutathione in their diabetic hearts. In the diabetic control, rats showed significantly increased serum cardiac parameters of CK, CRP, and LDH and also increased serum lipid profile parameters of LDL, cholesterol, and TG. Treatment with CA 25 mg/kg and 50 mg/kg showed significantly decreased CK, CRP, and LDH in diabetic-treated rats and decreased UA. Additionally, significantly decreased MDA, collagen, and increased activities of SOD and GSH were seen in the diabetic-treated rats. Histopathological findings also supported the beneficial effect of CA on the left ventricle of the heart. The present study revealed that the beneficial effects of CA on diabetic cardiovascular complications may be via anti-oxidative and anti-inflammatory actions.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"10 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A7, A Novel Analog of Curcumin, Induces Cell Apoptosis Through Suppressing TGF-βR/MEK/ERK Pathway in A549 Cells 姜黄素的一种新型类似物 A7 通过抑制 A549 细胞中的 TGF-βR/MEK/ERK 通路诱导细胞凋亡

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-14 DOI: 10.1007/s11094-024-03208-9

Pan Yu, Weiya Cao, Qianli Tang, Ruiqing Yan, Xinlan Tan, Zheyu Li

{"title":"A7, A Novel Analog of Curcumin, Induces Cell Apoptosis Through Suppressing TGF-βR/MEK/ERK Pathway in A549 Cells","authors":"Pan Yu, Weiya Cao, Qianli Tang, Ruiqing Yan, Xinlan Tan, Zheyu Li","doi":"10.1007/s11094-024-03208-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03208-9","url":null,"abstract":"Lung cancer is the leading cause of cancer death worldwide and curcumin is a natural polyphenol product with a diversity of antitumor activities. However, its clinical utility is limited due to its relatively low instability and poor bioavailability. This study evaluates the antitumor activity and the underlying mechanism of eight new curcumin analogs in A549 cells. Cell proliferation, migration and apoptosis were examined, respectively, through MTT assay, clone formation, wound healing, transwell, JC-1 staining, Bcl-2 activity, and caspase 3 activity. Protein levels of TGF-βR, MEK, and ERK were determined via western blotting. The binding mode of the ligand and the receptor was simulated by molecular docking studies. Compound A7 was found as the most potent analog (IC50 = 25.78 μM) compared to curcumin (IC50 = 42.30 μM). A7 exposure suppressed A549 cell migration and induced apoptosis with significant differences. Western blot and molecular docking studies demonstrated that the potential mechanism may relate to regulating the TGF-βR/MEK/ERK signaling pathway. Therefore, inhibiting this signaling pathway may provide a potential therapeutic strategy for lung cancer.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"47 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiproliferative Activity Compounds Isolated from the Marine Fungus Penicillium terrigenum 从海洋真菌青霉中分离出的抗增殖活性化合物

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-09-13 DOI: 10.1007/s11094-024-03204-z

Fan-ying Wu, Si-yuan Liu, Jie Feng

引用次数: 0

Modern Approaches to Mathematical Modeling of the Process of Direct Pressing of Tablets 直接压片工艺数学建模的现代方法

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-08-27 DOI: 10.1007/s11094-024-03194-y

V. B. Markeev, E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev, V. K. Alekseev

引用次数: 0

Determination of the Rosmarinic Acid Content in Mentha piperita L. Leaves by HPLC 用高效液相色谱法测定薄荷叶中的迷迭香酸含量

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-08-16 DOI: 10.1007/s11094-024-03191-1

V. A. Kurkin, M. A. Kazakova, A. R. Mubinov

引用次数: 0

Validated UV-Spectrophotometric Method for Pirfenidone Estimation in Bulk Drug, Marketed Tablet, and Nanoparticle Formulation 经验证的紫外分光光度法测定散装药物、上市片剂和纳米颗粒制剂中的吡非尼酮含量

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-08-16 DOI: 10.1007/s11094-024-03196-w

Kiran Dudhat, Janki Goswami, Dr. Harsha Patel

{"title":"Validated UV-Spectrophotometric Method for Pirfenidone Estimation in Bulk Drug, Marketed Tablet, and Nanoparticle Formulation","authors":"Kiran Dudhat, Janki Goswami, Dr. Harsha Patel","doi":"10.1007/s11094-024-03196-w","DOIUrl":"https://doi.org/10.1007/s11094-024-03196-w","url":null,"abstract":"The goal of the current research was to create an easy-to-understand, precise, and affordable UV-spectrophotometric method for measuring pirfenidone in bulk, in commercial formulations, and in nanoparticle form. The stock solution of pirfenidone was made using a phosphate buffer with a pH of 7.4, and the highest absorbance wavelength in the absorption spectrum was then identified. The standard curve was developed by preparing various working standard solutions from the aforementioned solution by dilution with the same diluents. This technique was also validated in accordance with International Council for Harmonization (ICH) guidelines. Pirfenidone showed the maximum absorptivity at 311 nm and the linearity range was found to be 10 – 50 μg/mL (R2 = 0.998). The limit of detection (LOD) and limit of quantification (LOQ) were 6.1140 μg/mL and 18.527 μg/mL respectively. The validity of all other parameters was determined to be acceptable. It was decided that the precision and accuracy were satisfactory. The developed processes were validated based on ICH standards. All of the validation parameters were found to be acceptable when compared with the standard values. Therefore, the suggested technique for pirfenidone determination in bulk drug and pharmaceutical formulation assays is applicable to everyday activities. The estimation of pirfenidone in pure form, commercial formulations, and nanoparticles was performed using an easy process that did not involve any potentially dangerous chemicals.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"4 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Acetaminophen Under Microwave Irradiation in the Presence of H-Clinoptilolite 微波辐照下在 H-Clinoptilolite 存在下合成对乙酰氨基酚

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-08-15 DOI: 10.1007/s11094-024-03193-z

G. H. Torosyan, P. A. Yesayan, H. H. Aleksanyan

引用次数: 0