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Development and Validation of a Gas-Chromatography–Mass-Spectrometry Method for Quantitative Determination of Ethylene Glycol and Diethylene Glycol in Solutions for Internal Use and Cough Syrups 气相色谱-质谱联用测定内服和止咳糖浆中乙二醇和二乙二醇的方法的建立和验证
4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2025-11-01 DOI: 10.1007/s11094-025-03472-3
N. A. Lezhnina, A. L. Khokhlov, N. A. Sidel’nikov, R. R. Galeev, D. V. Somov, I. A. Basalaeva
{"title":"Development and Validation of a Gas-Chromatography–Mass-Spectrometry Method for Quantitative Determination of Ethylene Glycol and Diethylene Glycol in Solutions for Internal Use and Cough Syrups","authors":"N. A. Lezhnina, A. L. Khokhlov, N. A. Sidel’nikov, R. R. Galeev, D. V. Somov, I. A. Basalaeva","doi":"10.1007/s11094-025-03472-3","DOIUrl":"https://doi.org/10.1007/s11094-025-03472-3","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"59 8","pages":"920-924"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Novel Pyrazolopyridine Analogs as Potential Anti-Hepatoma Agents by Suppressing the CXCR2/RAF/ERK Pathway 通过抑制CXCR2/RAF/ERK通路发现新的吡唑吡啶类似物作为潜在的抗肝癌药物
4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2025-06-01 DOI: 10.1007/s11094-025-03393-1
Weiya Cao, Pan Yu, Qizhu Feng, Shuhui Feng, Shilong Yang
{"title":"Discovery of Novel Pyrazolopyridine Analogs as Potential Anti-Hepatoma Agents by Suppressing the CXCR2/RAF/ERK Pathway","authors":"Weiya Cao, Pan Yu, Qizhu Feng, Shuhui Feng, Shilong Yang","doi":"10.1007/s11094-025-03393-1","DOIUrl":"https://doi.org/10.1007/s11094-025-03393-1","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"59 3","pages":"309-318"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Selective Fluorescent Probe for Quantitative Detection of Tiopronin Based on Fluorescence Enhancement 一种基于荧光增强的选择性荧光探针定量检测硫普罗宁
4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2025-05-01 DOI: 10.1007/s11094-025-03388-y
Yongfen Bao, Xingfeng Wang, Minjuan Wang, Shigang Shan, Mingjie Wei, Ya-Hui Ou
{"title":"A Selective Fluorescent Probe for Quantitative Detection of Tiopronin Based on Fluorescence Enhancement","authors":"Yongfen Bao, Xingfeng Wang, Minjuan Wang, Shigang Shan, Mingjie Wei, Ya-Hui Ou","doi":"10.1007/s11094-025-03388-y","DOIUrl":"https://doi.org/10.1007/s11094-025-03388-y","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"59 2","pages":"270-274"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ML385 Suppresses Hypoxia-Induced Drug Resistance and Cancer Stemness of Breast Cancer Cells by Blocking the Nrf2/HO-1 Pathway ML385通过阻断Nrf2/HO-1通路抑制缺氧诱导的乳腺癌细胞耐药和癌变
4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2025-01-01 DOI: 10.1007/s11094-025-03301-7
Huan Yang, Wentian Zheng, Hehua Lin, Hanxing Huang
{"title":"ML385 Suppresses Hypoxia-Induced Drug Resistance and Cancer Stemness of Breast Cancer Cells by Blocking the Nrf2/HO-1 Pathway","authors":"Huan Yang, Wentian Zheng, Hehua Lin, Hanxing Huang","doi":"10.1007/s11094-025-03301-7","DOIUrl":"https://doi.org/10.1007/s11094-025-03301-7","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"58 10","pages":"1506-1513"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Aloe-Emodin Decreases the Hypoxia-Induced Radioresistance by Interacting with Hypoxiainducible Factor-1 α in SU-DHL-4 Cells 芦荟-大黄素通过与缺氧诱导因子-1 α相互作用降低SU-DHL-4细胞缺氧诱导的辐射抗性
4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2025-01-01 DOI: 10.1007/s11094-025-03300-8
Lili Zhang, Xiaojie Wang, Yue Zhang, Hui Gao, Yu He, Mengmeng Liu
{"title":"Aloe-Emodin Decreases the Hypoxia-Induced Radioresistance by Interacting with Hypoxiainducible Factor-1 α in SU-DHL-4 Cells","authors":"Lili Zhang, Xiaojie Wang, Yue Zhang, Hui Gao, Yu He, Mengmeng Liu","doi":"10.1007/s11094-025-03300-8","DOIUrl":"https://doi.org/10.1007/s11094-025-03300-8","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"58 10","pages":"1498-1505"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening, Synthesis and Biological Evaluation of Novel Bruton’s Tyrosine Kinase Inhibitors 新型布鲁顿酪氨酸激酶抑制剂的筛选、合成及生物学评价
4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2024-11-01 DOI: 10.1007/s11094-024-03270-3
Q. Xu, Rongchen Li, Li Zhu, Wenjiang Ma, Yu-Ning Gao, Huiyu Chen, Zhenjiang Liu
{"title":"Screening, Synthesis and Biological Evaluation of Novel Bruton’s Tyrosine Kinase Inhibitors","authors":"Q. Xu, Rongchen Li, Li Zhu, Wenjiang Ma, Yu-Ning Gao, Huiyu Chen, Zhenjiang Liu","doi":"10.1007/s11094-024-03270-3","DOIUrl":"https://doi.org/10.1007/s11094-024-03270-3","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"58 8","pages":"1273-1284"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, Physicochemical Properties, and Antibacterial Activity of Hydrogel Films Based on Starch and Poly(Vinyl Alcohol) with Added Ethonium 基于淀粉和添加了乙醇的聚乙烯醇的水凝胶薄膜的制备、理化性质和抗菌活性
IF 0.9 4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2024-09-18 DOI: 10.1007/s11094-024-03213-y
T. V. Kryuk, T. I. Zavyazkina, T. G. Tyurina, G. P. Goncharuk, M. V. Buyanovskaya, V. A. Senenko
{"title":"Preparation, Physicochemical Properties, and Antibacterial Activity of Hydrogel Films Based on Starch and Poly(Vinyl Alcohol) with Added Ethonium","authors":"T. V. Kryuk, T. I. Zavyazkina, T. G. Tyurina, G. P. Goncharuk, M. V. Buyanovskaya, V. A. Senenko","doi":"10.1007/s11094-024-03213-y","DOIUrl":"https://doi.org/10.1007/s11094-024-03213-y","url":null,"abstract":"<p>Hydrogel films with a polymer base of corn starch and poly(vinyl alcohol) (50:50 wt%), citric acid as a crosslinking agent, and glycerin as a plasticizer were synthesized. Their physical and mechanical characteristics corresponded to the performance level of commercial wound dressings of the same type. The degree of swelling increased by ~30%, whereas the elastic modulus and water-vapor permeability decreased by ~60% when ethonium was introduced into the polymer matrix (from 1 to 5 wt% of the polymer weight). Drug release from the polymer matrix occurred within 90-105 min at drug contents of 2.5-5 wt%. The developed films inhibited the growth of the microorganisms <i>E. coli</i> and <i>P. aeruginosa</i>.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"10 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Changes in Enterosgel Structure in Case of Violation of Drug Storage Conditions 违反药物储存条件时肠溶凝胶结构变化的研究
IF 0.9 4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2024-09-18 DOI: 10.1007/s11094-024-03214-x
N. E. Kuz’mina, S. V. Moiseev, E. Yu. Severinova, V. M. Shchukin, N. D. Bunyatyan
{"title":"Study of Changes in Enterosgel Structure in Case of Violation of Drug Storage Conditions","authors":"N. E. Kuz’mina, S. V. Moiseev, E. Yu. Severinova, V. M. Shchukin, N. D. Bunyatyan","doi":"10.1007/s11094-024-03214-x","DOIUrl":"https://doi.org/10.1007/s11094-024-03214-x","url":null,"abstract":"<p>The structure of enterosgel before and after freezing (samples I and II, respectively) was comparatively analyzed by gravimetric analysis and NMR methods [PMR, <sup>13</sup>C NMR, diffusion-ordered NMR spectroscopy (DOSY)] to understand the reason for the negative effect of freezing on the adsorption capacity of enterosgel. The methylsiloxane moieties in samples I and II were shown to be magnetically equivalent by PMR and <sup>13</sup>C NMR methods. The molecular masses of samples I and II were estimated by the DOSY method and corresponded to the cyclic dimer of methylsilicic acid (MM 152 Da) for sample I and the linear dimer of methylsilicic acid (MM 170 Da) for sample II. It was hypothesized that the conformationally rigid cyclic dimer structure was destroyed upon freezing of enterosgel due to rupture of a siloxane bond. The adsorption capacity of enterosgel deteriorated because of the structure disruption and hydrophobicity change. Thermogravimetric analysis revealed that water did not participate in hydrogen bonding with enterosgel.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"19 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, In Vitro Antimycobacterial Activity of Some 2-((5-Amino-1,3,4-Thiadiazol-2-YL)Methyl)-6-Aryl-Tetrahydropyridazin-3-One Derivatives 一些 2-((5-氨基-1,3,4-噻二唑-2-YL)甲基)-6-芳基四氢哒嗪-3-酮衍生物的合成和体外抗霉菌活性
IF 0.9 4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2024-09-18 DOI: 10.1007/s11094-024-03203-0
Mamdouh Allahyani, Abdulaziz Alsharif, Mazen Almehmadi, Shivani Verma, Mohammad Asif
{"title":"Synthesis, In Vitro Antimycobacterial Activity of Some 2-((5-Amino-1,3,4-Thiadiazol-2-YL)Methyl)-6-Aryl-Tetrahydropyridazin-3-One Derivatives","authors":"Mamdouh Allahyani, Abdulaziz Alsharif, Mazen Almehmadi, Shivani Verma, Mohammad Asif","doi":"10.1007/s11094-024-03203-0","DOIUrl":"https://doi.org/10.1007/s11094-024-03203-0","url":null,"abstract":"<p>A series of 2-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-6-aryl-2,3,4,5-tetrahydro-pyridazin-3-one (<b>4a-e</b>) was synthesized and evaluated for its <i>in vitro</i> antimycobacterial activity. All the synthesized compounds were structurally confirmed by using physicochemical and spectral analysis such as melting point, <i>R</i><sub><i>f</i></sub> value, elemental analysis, IR, NMR and mass spectra. <i>In vitro</i> antimycobacterial activity was screened by the microplate Alamar Blue Assay (MABA) method against <i>Mycobacterium tuberculosis</i> H37Rv strain. Derivatives with 4-ethyl phenyl substitution (<b>4b</b>) and chloro phenyl substitution (<b>4e</b>) at the <i>p</i>-position of pyridazinone nuclei showed good antimycobacterial activity with a MIC value of 6.25 μg/ml compared to other aryl substitutions such as 4-methoxy phenyl (<b>4a</b>), 4-methyl phenyl (<b>4c</b>) with a MIC value of 25 and 12.5 μg/ml. The results of <i>in vitro</i> antimycobacterial activity revealed that the synthesized compounds have potential antimycobacterial action and can be further optimized and developed as lead compounds.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"203 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPLC Determination of Myricitrin in Leaves of Common Myrtle (Myrtus communis L.) 高效液相色谱法测定普通桃金娘叶（Myrtus communis L.）
IF 0.9 4区 医学
Pharmaceutical Chemistry Journal Pub Date : 2024-09-18 DOI: 10.1007/s11094-024-03211-0
V. A. Kurkin, V. D. Maslova, A. R. Mubinov
{"title":"HPLC Determination of Myricitrin in Leaves of Common Myrtle (Myrtus communis L.)","authors":"V. A. Kurkin, V. D. Maslova, A. R. Mubinov","doi":"10.1007/s11094-024-03211-0","DOIUrl":"https://doi.org/10.1007/s11094-024-03211-0","url":null,"abstract":"<p>A method for quantitative determination of myricitrin in common myrtle (<i>Myrtus communis</i> L.) leaves using high-performance liquid chromatograph (HPLC) was developed. The content of the dominant flavonoid myricitrin (myricetin 3-<i>O</i>-α-L-rhamnopyranoside) in common myrtle leaves varied from 0.98 ± 0.02% to 1.51 ± 0.07%. The error of a single determination and the average error of the myricitrin content determination in common myrtle leaves were ±15.81% and ±4.77%, respectively, with confidence probability 95%.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"36 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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