Preparation, Physicochemical Properties, and Antibacterial Activity of Hydrogel Films Based on Starch and Poly(Vinyl Alcohol) with Added Ethonium

IF 0.8 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmaceutical Chemistry Journal Pub Date : 2024-09-18 DOI:10.1007/s11094-024-03213-y

T. V. Kryuk, T. I. Zavyazkina, T. G. Tyurina, G. P. Goncharuk, M. V. Buyanovskaya, V. A. Senenko

引用次数: 0

Abstract

Hydrogel films with a polymer base of corn starch and poly(vinyl alcohol) (50:50 wt%), citric acid as a crosslinking agent, and glycerin as a plasticizer were synthesized. Their physical and mechanical characteristics corresponded to the performance level of commercial wound dressings of the same type. The degree of swelling increased by ~30%, whereas the elastic modulus and water-vapor permeability decreased by ~60% when ethonium was introduced into the polymer matrix (from 1 to 5 wt% of the polymer weight). Drug release from the polymer matrix occurred within 90-105 min at drug contents of 2.5-5 wt%. The developed films inhibited the growth of the microorganisms E. coli and P. aeruginosa.

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基于淀粉和添加了乙醇的聚乙烯醇的水凝胶薄膜的制备、理化性质和抗菌活性

以玉米淀粉和聚乙烯醇（50:50 wt%）为聚合物基质，柠檬酸为交联剂，甘油为增塑剂，合成了水凝胶薄膜。它们的物理和机械特性与同类商用伤口敷料的性能水平相当。在聚合物基质中引入乙铵（占聚合物重量的 1 至 5 wt%）后，溶胀度增加了约 30%，而弹性模量和水蒸气渗透性则降低了约 60%。当药物含量为 2.5-5 wt% 时，药物可在 90-105 分钟内从聚合物基质中释放出来。所开发的薄膜抑制了微生物大肠杆菌和绿脓杆菌的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

1.30

自引率

22.20%

发文量

226

审稿时长

3-8 weeks

期刊介绍： Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.