Pharmaceutical Chemistry Journal最新文献_第10页

Mechanical Inclusions in Ophthalmic Drugs 眼科药物中的机械夹杂物

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-16 DOI: 10.1007/s11094-024-03109-x

O. V. Gunar, A. V. Dorenskaya, N. G. Sakhno

引用次数: 0

The Prophylactic Effects of Isosteviol Aerosol Inhalation on Bronchial Asthma in Mice 吸入异十三醇气雾剂对小鼠支气管哮喘的预防作用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-15 DOI: 10.1007/s11094-024-03091-4

Haihua Guo, Meng Li, Yue Lin, Zizhao Zhai, Guanlin Wang, Suqing Zhao

{"title":"The Prophylactic Effects of Isosteviol Aerosol Inhalation on Bronchial Asthma in Mice","authors":"Haihua Guo, Meng Li, Yue Lin, Zizhao Zhai, Guanlin Wang, Suqing Zhao","doi":"10.1007/s11094-024-03091-4","DOIUrl":"https://doi.org/10.1007/s11094-024-03091-4","url":null,"abstract":"The diterpenoid isosteviol is one of the stevia derivatives that have reported various activities. In mice inhaling isosteviol, OVA- and ACh-induced bronchial asthma showed a dose-dependent improvement of a decline in the expression of inflammatory cytokines and the infiltration of basophils. Compared with inhalation of budesonide 0.6 mg/kg, sensitized mice inhaling 1.0 mg/kg dosage of isosteviol performed a higher tolerate against the ACh stimulation. In behavior tests, the 1.0 mg/kg isosteviol nebulization reached almost 80% of the level of budesonide with regard to the ameliorative effects on depression-like behavior and improvement in sport ability. In addition, lung and systemic inflammation were markedly prevented by isosteviol with a dosage of more than 0.6 mg/kg, which exhibited limited expression of IL-1β and TNF-α, less infiltration of basophils in lung tissues, and a low level of systemic immunocytes, which showed in hematoxylin and eosin staining, RT-PCR, and ELISA results. On the other hand, none of the abnormal pathology was found in both peripheral and central organs of all the administration groups. Generally, this study implicated that the mechanism could involve effects of isosteviol inhalation on the suppression of IL-1β and TNF-α to restrict a systemic upsurge of immunocytes and infiltration into the lung that prevents the occurrence of depression-like behavior and hypokinesia.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"29 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140560142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prospects of 5-Androstenediol and its Synthetic Derivatives as Novel Radioprotective Drugs 5-雄烯二醇及其合成衍生物作为新型辐射防护药物的前景

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-15 DOI: 10.1007/s11094-024-03088-z

M. E. Uspenskaya, T. A. Fedotcheva, A. N. Usenko, N. L. Shimanovsky

引用次数: 0

Imidazo[4,5-a]acridines and Pyrazolo[4,3-a]acridines as a New Class of Urease Inhibitors: Synthesis, In Vitro Interactions, and Molecular Docking Studies 咪唑并[4,5-a]吖啶和吡唑并[4,3-a]吖啶作为新型尿素酶抑制剂：合成、体外相互作用和分子对接研究

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-15 DOI: 10.1007/s11094-024-03097-y

Javad Mohammadi, Mehdi Pordel, Mohammad Reza Bozorgmehr

引用次数: 0

Recent Advancements and Biological Activities of Triazole Derivatives: a Short Review 三唑衍生物的最新进展和生物活性：简评

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-15 DOI: 10.1007/s11094-024-03096-z

Shobha Rani, Shiva Teotia, Sumitra Nain

引用次数: 0

Low Molecular Weight NGF Mimetic Enhances the Overall Plasma Antioxidant Capacity in Rats with Streptozotocin-Induced Diabetes 低分子量 NGF 拟态物质提高链脲佐菌素诱导糖尿病大鼠血浆的整体抗氧化能力

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-15 DOI: 10.1007/s11094-024-03089-y

S. V. Ivanov, R. U. Ostrovskaya, V. V. Olicheva, A. D. Savina, R. P. Terekhov, I. R. Ilyasov, I. A. Selivanova, T. A. Gudasheva

引用次数: 0

Synthesis and In Silico Prediction of the Molecular-Targeting Anti-EGFR Action of a Novel Dihydroacridinone 一种新型二氢吖啶酮的合成及分子靶向抗EGFR作用的硅学预测

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-13 DOI: 10.1007/s11094-024-03092-3

A. A. Epishkina, E. V. Bogoslovskaya, V. A. Pakina, A. I. Osipiantz, E. A. Kutorkina, E. A. Livin, O. M. Tumutolova, S. Ya. Skachilova, K. D. Blinov, E. V. Semeleva, D. N. Shimanovsky, I. V. Fedoseikin, M. V. Tolstov, E. V. Blinova, E. V. Shikh, D. S. Blinov

{"title":"Synthesis and In Silico Prediction of the Molecular-Targeting Anti-EGFR Action of a Novel Dihydroacridinone","authors":"A. A. Epishkina, E. V. Bogoslovskaya, V. A. Pakina, A. I. Osipiantz, E. A. Kutorkina, E. A. Livin, O. M. Tumutolova, S. Ya. Skachilova, K. D. Blinov, E. V. Semeleva, D. N. Shimanovsky, I. V. Fedoseikin, M. V. Tolstov, E. V. Blinova, E. V. Shikh, D. S. Blinov","doi":"10.1007/s11094-024-03092-3","DOIUrl":"https://doi.org/10.1007/s11094-024-03092-3","url":null,"abstract":"The synthesis and in silico prediction of the molecular-targeted anti-EGFR inhibitory activity of a novel dihydroacridinone derivative are reported. 9-Aminium-3,3-dimethyl-3,4-dihydroacridin-1(2H)-one L-2-hydroxybutanedioate (LHT-17-19) was obtained 99.8% pure by mixing and heating equimolar amounts of 9-amino-3,3-dimethyl-3,4-dihydroacridin-1(2H)-one and L-2-hydroxybutanedioic acid in 50% EtOH. Virtual molecular screening of the spectrum of effects of the compound revealed inhibitory properties against several intracellular targets, i.e., carcinogenesis drivers, among which the EGFR kinase domain had the highest probability. Docking of LHT-17-19 base to the EGFR kinase domain formed a molecular complex with a high affinity and bonding energy. The results suggested that LHT-17-19 had high antitumor activity against malignant neoplasms expressing EGFR.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"38 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140560123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic Effect of Comenic Acid in Acute Pain Models in Rats 苦味酸对大鼠急性疼痛模型的镇痛效果

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-03-25 DOI: 10.1007/s11094-024-03069-2

A. L. Kovalenko, A. Yu. Petrov, N. A. Lycheva, Ye.A. Roshchina, Ye.B. Artyushkova, I. I. Bobyntsev, A. O. Vorvul

{"title":"Analgesic Effect of Comenic Acid in Acute Pain Models in Rats","authors":"A. L. Kovalenko, A. Yu. Petrov, N. A. Lycheva, Ye.A. Roshchina, Ye.B. Artyushkova, I. I. Bobyntsev, A. O. Vorvul","doi":"10.1007/s11094-024-03069-2","DOIUrl":"https://doi.org/10.1007/s11094-024-03069-2","url":null,"abstract":"Comenic (5-hydroxy-4-oxo-4H-pyran-2-carboxylic) acid is regarded as a new analgesic agent. Comenic acid (CA) was studied in acute pain models using Wistar rats in the tail-flick and hot-plate tests. CA was administered in a single intramuscular injection 30 min before the tests. The reference drug (INN diclofenac) was administered at a dose of 6.6 mg/kg; the test drug (CA solution), at doses of 20, 40, and 60 mg/kg. Tests were performed 15 min and immediately before CA administration and 30, 45, and 60 min after administration. The maximum possible effect (MPE) was calculated for each test at the end of the studies. No statistically significant differences were found between experimental groups in the tail-flick test. The MPE in the hot-plate test for the test and reference drug groups was significantly higher than that in the control group at all time points (30, 45, and 60 min after administration of the drugs). CA was found to have a lesser effect on the formation of a spinal reflex (tail-flick test) but was rather effective in tests involving supraspinal structures (hot-plate test). No toxic manifestations (according to clinical observation and animal body weight) and dose dependence were identified.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"182 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140299471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs 一些含丁香酚和愈创木酚的希夫碱：尿素酶抑制和抗幽门螺旋杆菌活性与其偶氮类似物的比较

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-03-20 DOI: 10.1007/s11094-024-03074-5

Cihan Kantar, Nimet Baltaş, Şengül Alpay Karaoğlu, Selami Şaşmaz

引用次数: 0

Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic 4,10-二(2-乙氧基乙酰基)-2,6,8,12-四乙酰基-2,4,6,8,10,12-六氮aisowurtzitane--一种创新的非麻醉性镇痛药的现代化合成与抗炎活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-03-20 DOI: 10.1007/s11094-024-03068-3

引用次数: 0