Shreenivas Deshpande, Manappa T. Mandalamari, Prasad V. Malagi, Chandrashekhar V. M.
{"title":"Synthesis, In Silico Analysis, Antibacterial, Radical Scavenging and Antidiabetic Activities of Certain Bis-Azetidinones and Bis-Thiazolidinones","authors":"Shreenivas Deshpande, Manappa T. Mandalamari, Prasad V. Malagi, Chandrashekhar V. M.","doi":"10.1007/s11094-024-03119-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03119-9","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacological Properties of Acetylsalicylic Acid and its Complex with Glycyrrhizic Acid as a Promising Dosage form (Review)","authors":"R. Khisamutdinova, L. Baltina, T. Sapozhnikova","doi":"10.1007/s11094-024-03115-z","DOIUrl":"https://doi.org/10.1007/s11094-024-03115-z","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. L. Belyanin, O. Borodin, T. P. Novozheeva, A. S. Podyablonskiy, M. V. Belousov, O. A. Subbotina, W. Ussov, N. L. Shimanovskiy
{"title":"Study of Organ Uptake of the New Hepatotropic Paramagnetic Contrast Agent, the Mn(II) Complex of 2-[2-Carboxymethyl-(4-Hexadecyloxyphenylcarbamoylmethyl)-Aminoethyl]-Aminoethyl-(4-Hexadecyloxyphenylcarbamoylmethyl)-Aminoacetic Acid (Mn-DTPA-GDOF), In Vivo in Some Experimental Models of Liver Damage ","authors":"M. L. Belyanin, O. Borodin, T. P. Novozheeva, A. S. Podyablonskiy, M. V. Belousov, O. A. Subbotina, W. Ussov, N. L. Shimanovskiy","doi":"10.1007/s11094-024-03117-x","DOIUrl":"https://doi.org/10.1007/s11094-024-03117-x","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Glycyrrhizic Acid on the Viability of Hela Cervical Adenocarcinoma Cell Line at Different Concentrations of Sex Steroid Hormones","authors":"M. S. Filimonova, N. L. Shimanovskiy","doi":"10.1007/s11094-024-03112-2","DOIUrl":"https://doi.org/10.1007/s11094-024-03112-2","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. A. Savel’ev, A. G. Mittenberg, T. I. Aref’eva, T. I. Oparina, S. V. Chepanov, S. A. Sel’kov
{"title":"Peptide Composition and Identification of a Peptide with Anti-Inflammatory and Antiplatelet Properties in Cattle Prostate Extract","authors":"S. A. Savel’ev, A. G. Mittenberg, T. I. Aref’eva, T. I. Oparina, S. V. Chepanov, S. A. Sel’kov","doi":"10.1007/s11094-024-03116-y","DOIUrl":"https://doi.org/10.1007/s11094-024-03116-y","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-Inflammatory and Analgesic Activity of Ethanolic Extract of Tubers and Different Fractions of Eulophia nuda Lindl.","authors":"Sonal Hada, Vishakha Sharma, Chetna Ameta, Dinesh Kumar Yadav, N. Kumari","doi":"10.1007/s11094-024-03122-0","DOIUrl":"https://doi.org/10.1007/s11094-024-03122-0","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140976128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. A. Semkina, O. M. Beloshapkina, M. A. Dzhavakhyan
{"title":"Prospects for Production of Microencapsulated Medicines Based on Plant Extracts (Review)","authors":"O. A. Semkina, O. M. Beloshapkina, M. A. Dzhavakhyan","doi":"10.1007/s11094-024-03121-1","DOIUrl":"https://doi.org/10.1007/s11094-024-03121-1","url":null,"abstract":"<p>Material devoted to the peculiarities of plant extract microencapsulation used for the development and production of drugs and active substances with pharmacological activity is reviewed. The advantages of some microencapsulation methods of plant extracts are shown: emulsification (dispersion), coacervation, ionic gelation, spray and freeze drying, solvent evaporation, extrusion, fluidized bed microencapsulation. The parameters for choosing an encapsulation method for plant extracts were determined. Possible prospects for microencapsulation technology of plant extracts were described. Domestic and foreign literature sources in the public domain were analyzed using the electronic databases PubMed, e-Library, and CyberLeninka and Google Scholar search engine.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140929854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. E. Krasheninnikov, V. V. Sepp, K. S. Bakulin, O. I. Arefieva, A. A. Karsanov
{"title":"Impact of Ultrasonic Vibrations on the Stability of Bovhyaluronidase Azoximer in Solution","authors":"A. E. Krasheninnikov, V. V. Sepp, K. S. Bakulin, O. I. Arefieva, A. A. Karsanov","doi":"10.1007/s11094-024-03127-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03127-9","url":null,"abstract":"<p>Changes in the quantitative content and specific activity of hyaluronidase enzyme after ultrasonic treatment of solutions of bovhyaluronidase azoximer were studied. Solutions of the finished dosage form of bovhyaluronidase azoximer (Longidase<sup>®</sup> lyophilizate for preparation of solution for injection, 3000 IE) and bovhyaluronidase azoximer drug substance (Longidase<sup>®</sup> substance-lyophilizate) were studied. The aim of the study was to determine the effect of ultrasound (US) on the stability of bovhyaluronidase azoximer determined from the measured quantitative content and enzymatic activity of the substance in solution. US at a radiation intensity of 61.4 W/L during treatment in an ultrasonic bath did not significantly affect the quantitative content of the bovhyaluronidase azoximer drug substance in solution, while the decrease in the enzymatic activity of the active substance in Longidase solution after 20 and 30 min of ultrasonic treatment was statistically significant. At the same time, the enzymatic activity of the active substance determined by a biochemical method differed significantly (residual activity from 99.70% to 59.27%) depending on the design features of the nebulizers and the nebulization time after nebulization of the bovhyaluronidase azoximer solution in mesh nebulizers from various manufacturers. Nebulization times of min were least associated with the risk of significant loss of stability of bovhyaluronidase azoximer.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140929628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. I. Gavrilov, E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev
{"title":"Formulating GML-1 Tablets Using the Harrington Desirability Function","authors":"D. I. Gavrilov, E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev","doi":"10.1007/s11094-024-03126-w","DOIUrl":"https://doi.org/10.1007/s11094-024-03126-w","url":null,"abstract":"<p>Features of using the generalized Harrington desirability function for the selection of a binder and lubricant for GML-1 (<i>N</i>-benzyl-<i>N</i>-methyl-1-phenylpyrrolo[1,2-<i>a</i>]pyrazine-3-carboxamide) tablets are considered. The factors affecting the characteristics of the finished dosage form are evaluated. Model formulations with different qualitative and quantitative compositions of disintegrant and lubricant excipients were developed. Their pharmaceutical and technological properties were studied. The factors having the greatest impact on indicators such as the mass loss on drying, strength, disintegration, and solubility of the tablets were identified. The type and amount of disintegrant and lubricant in the tablet that could produce a dosage form with the optimal pharmaceutical and technological characteristics were determined.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140929564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}