Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs

IF 0.8 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmaceutical Chemistry Journal Pub Date : 2024-03-20 DOI:10.1007/s11094-024-03074-5

Cihan Kantar, Nimet Baltaş, Şengül Alpay Karaoğlu, Selami Şaşmaz

引用次数: 0

Abstract

To improve and develop our monotherapeutic approach for Helicobacter pylori infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, and Anti-Helicobacter pylori effect were investigated and compared with azo analogs in the literature. All Schiff base compounds have been found to have both stronger urease enzyme inhibitory and more effective Anti-Helicobacter pylori properties than its azo analogs. In particular, the antimicrobial effect of Schiff bases containing eugenol increased dramatically when compared to their azo analogs.

查看原文本刊更多论文

一些含丁香酚和愈创木酚的希夫碱：尿素酶抑制和抗幽门螺旋杆菌活性与其偶氮类似物的比较

为了改进和发展我们治疗幽门螺旋杆菌感染的单一疗法，我们合成了一些含有丁香酚和愈创木酚的席夫碱化合物，并研究了它们的抗氧化能力、脲酶抑制作用和抗幽门螺旋杆菌效果，并与文献中的偶氮类似物进行了比较。研究发现，与偶氮类似物相比，所有希夫碱化合物都具有更强的抑制脲酶酶和更有效的抗幽门螺旋杆菌的特性。与偶氮类似物相比，含有丁香酚的席夫碱化合物的抗菌效果尤其显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

1.30

自引率

22.20%

发文量

226

审稿时长

3-8 weeks

期刊介绍： Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.