苦味酸对大鼠急性疼痛模型的镇痛效果

IF 0.8 4区 医学 Q4 CHEMISTRY, MEDICINAL
A. L. Kovalenko, A. Yu. Petrov, N. A. Lycheva, Ye.A. Roshchina, Ye.B. Artyushkova, I. I. Bobyntsev, A. O. Vorvul
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引用次数: 0

摘要

柯美尼克酸(5-羟基-4-氧代-4H-吡喃-2-羧酸)被认为是一种新型镇痛剂。研究人员利用 Wistar 大鼠的急性疼痛模型,对柯美尼克酸(CA)进行了尾搔试验和热板试验。CA 在测试前 30 分钟进行一次肌肉注射。参照药物(INN 双氯芬酸)的剂量为 6.6 毫克/千克;试验药物(CA 溶液)的剂量为 20、40 和 60 毫克/千克。测试在 CA 给药前 15 分钟和给药后 30、45 和 60 分钟进行。研究结束时计算了每次试验的最大可能效应(MPE)。在尾闪试验中,各实验组之间没有发现明显的统计学差异。在热板试验中,试验组和参照药物组在所有时间点(给药后 30、45 和 60 分钟)的最大可能效应都明显高于对照组。研究发现,CA 对脊髓反射(弹尾试验)的形成影响较小,但对涉及脊髓上结构的试验(热板试验)却相当有效。没有发现毒性表现(根据临床观察和动物体重)和剂量依赖性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analgesic Effect of Comenic Acid in Acute Pain Models in Rats

Comenic (5-hydroxy-4-oxo-4H-pyran-2-carboxylic) acid is regarded as a new analgesic agent. Comenic acid (CA) was studied in acute pain models using Wistar rats in the tail-flick and hot-plate tests. CA was administered in a single intramuscular injection 30 min before the tests. The reference drug (INN diclofenac) was administered at a dose of 6.6 mg/kg; the test drug (CA solution), at doses of 20, 40, and 60 mg/kg. Tests were performed 15 min and immediately before CA administration and 30, 45, and 60 min after administration. The maximum possible effect (MPE) was calculated for each test at the end of the studies. No statistically significant differences were found between experimental groups in the tail-flick test. The MPE in the hot-plate test for the test and reference drug groups was significantly higher than that in the control group at all time points (30, 45, and 60 min after administration of the drugs). CA was found to have a lesser effect on the formation of a spinal reflex (tail-flick test) but was rather effective in tests involving supraspinal structures (hot-plate test). No toxic manifestations (according to clinical observation and animal body weight) and dose dependence were identified.

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来源期刊
Pharmaceutical Chemistry Journal
Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY
CiteScore
1.30
自引率
22.20%
发文量
226
审稿时长
3-8 weeks
期刊介绍: Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.
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