Pharmaceutical Chemistry Journal最新文献_第9页

Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways 作为血液肿瘤屏障强效调节剂的六种邻苯二甲酸酯类化合物可通过跨细胞和细胞外途径增加兼容化合物的跨膜转运

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03103-3

Xiao-jin Liu, Shu-yuan Shuai, Guo-song Zhang, Qin Zheng, Peng-yi Hu, Zi-qi Li, Ri-qun Liu, Shu-hua Xiao

{"title":"Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways","authors":"Xiao-jin Liu, Shu-yuan Shuai, Guo-song Zhang, Qin Zheng, Peng-yi Hu, Zi-qi Li, Ri-qun Liu, Shu-hua Xiao","doi":"10.1007/s11094-024-03103-3","DOIUrl":"https://doi.org/10.1007/s11094-024-03103-3","url":null,"abstract":"The treatment of brain tumors is greatly limited due to the presence of the blood tumor barrier (BTB). Our previous research has shown that the essential oil of chuanxiong promoted temozolomide entry into glioma cells and enhanced temozolomide-induced anticancer efficiency in vivo. Phthalides account for the largest proportion of essential oil and, therefore, this study was conducted to investigate the effects of six phthalides on the transmembrane transport of compatible compounds across the BTB and the mechanism. The results showed that different concentrations of senkyunolide H (SH), senkyunolide A (SA), ligustilide (LIG), butylidenephthalide (BP), n-butylphthalide (NBP) and neocnidilide (NOL) significantly increase the permeability from A (apical side) to B (basolateral side) (Papp(AB)) of fluorescein isothiocyanate 4000 (FITC4000), while NBP, NOL and SA could also significantly increase Papp(B→A). Western blot analysis indicated that these phthalides down-regulated expressions of claudin-5, occludin and ZO-1 to increase the permeability of BTB. LIG, SA, SH, NBP and NOL significantly increased Papp(AB) and the efflux ratio of the P-gp substrate rhodamine 123 attribute to down-regulate the expressions of P-gp. The expression of caveolin-1 was also down-regulated by the six phthalides. LIG, SA, SH, NBP and NOL acted as effective absorption enhancers in BTB via both the transcellular route and the paracellular route.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"184 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the Pressing Process of N-Butyl-N-Methyl-1-Phenylpyrrolo-[1,2-a]Pyrazine-3-Carboxamide (GML-3) Tablets Using Mathematical Modeling Techniques 利用数学建模技术研究 N-丁基-N-甲基-1-苯基吡咯并[1,2-a]吡嗪-3-甲酰胺（GML-3）片剂的压片工艺

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03107-z

V. B. Markeev, S. V. Tishkov, E. V. Blynskaya, K. V. Alekseev

引用次数: 0

Chemical Composition and Antioxidant Activity of Petroleum Ether Extract from Kaempferia galanga L. 山奈石油醚提取物的化学成分和抗氧化活性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03101-5

Zhaobao Xiang, Xueli Ping, Pengfei Chen, Linfeng You, Bin Zhou

{"title":"Chemical Composition and Antioxidant Activity of Petroleum Ether Extract from Kaempferia galanga L.","authors":"Zhaobao Xiang, Xueli Ping, Pengfei Chen, Linfeng You, Bin Zhou","doi":"10.1007/s11094-024-03101-5","DOIUrl":"https://doi.org/10.1007/s11094-024-03101-5","url":null,"abstract":"Kaempferia galanga L. (KGL) from Hainan, China was extracted by ultrasonic-assisted extraction with 90% ethanol solution, and then extracted with petroleum ether after the ethanol extract was recovered to be alcohol free. The antioxidant activity of the petroleum ether fraction of KGL was first tested using the ABTS method. GC-MS was used to analyze the chemical constituents of the petroleum ether fraction. The scavenging effect on ABTS free radicals of the petroleum ether fraction was weak, indicating that the antioxidant activity of the petroleum ether fraction was moderate. A total of 25 chemical components were identified by GC-MS analysis. The main components with higher content were 2,6,11-trimethyl dodecane, ethyl p-methoxy cinnamate, and ethyl cinnamate, which accounted for 81.64%. Furthermore, 11 kinds of constituents of the petroleum ether extract were obtained from KGL for the first time. This experiment clarifies firstly the main chemical composition of petroleum ether fraction from KGL, which provides some scientific basis for the further exploration and use of petroleum ether fraction from KGL and the comparative analysis of the chemical composition of KGL in different regions.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"20 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of Phytochemicals as Nutraceutical in the Prophylaxis of Dengue 利用植物化学物质作为预防登革热的保健品

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03105-1

Jyoti Baranwal, Swastika Singh, Smriti Kushwaha, Archana Jyoti

引用次数: 0

Prospects of Creating Collagen Substances Based on a Study of the Physical and Chemical Characteristics of Proteins of Hydrobiont Dermal Emulsions 根据对 Hydrobiont 皮肤乳液蛋白质的物理和化学特性的研究创建胶原蛋白物质的前景

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03108-y

S. S. Antipov, D. V. Tarasova, M. M. Borodina, M. V. Likhodzievskaya, D. A. Cherenkov, T. N. Khmelevskaya, L. V. Antipova, V. G. Artyukhov

{"title":"Prospects of Creating Collagen Substances Based on a Study of the Physical and Chemical Characteristics of Proteins of Hydrobiont Dermal Emulsions","authors":"S. S. Antipov, D. V. Tarasova, M. M. Borodina, M. V. Likhodzievskaya, D. A. Cherenkov, T. N. Khmelevskaya, L. V. Antipova, V. G. Artyukhov","doi":"10.1007/s11094-024-03108-y","DOIUrl":"https://doi.org/10.1007/s11094-024-03108-y","url":null,"abstract":"Proteins of the collagen family were identified in the dermal emulsion of a freshwater fish, the African clary catfish (Clarias gariepinus). Acumulative assessment of their physicochemical properties gave reason to consider the emulsion obtained using the developed method as a source of functional biopolymers, particularly collagen proteins. The fractional composition, charge state, molecular mass, and the ability for hydrolysis by Clostridium histolytica collagenase were experimentally determined. Evaluation of the amino-acid composition allowed the analogy and features of collagen proteins of animal and fish origin to be identified. The studied emulsions were shown to contain negatively charged proteins with molecular masses >100 kDa, the fractions of which contained predominantly collagen. The results supported the assumption that a significant part of the hydrobiont collagen was type I collagen, which made it possible to consider them in the future as a basis for various substances and served as a starting point for understanding the physicochemical functioning essentials and assessing the possibility of using them in pharmaceutical technologies.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"16 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Vitro Effect of Ammodaucus Leucotrichus Flower and Fruit Essential Oils on Nitric Oxide Production and Arginase Activity in Human Peripheral Blood Mononuclear Cells (PBMC) from Patients with Behçet Disease Ammodaucus Leucotrichus 花和果精油对白塞氏病患者外周血单核细胞（PBMC）一氧化氮生成和精氨酸酶活性的体外效应

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03104-2

Djamel Messaoudene, Nourelhouda Ghozali, Hayet Neghliz, Tarek Benabdelkader, Houda Belguendouz, Malika Terahi, Fifi Otmani, Chafia Touil-Boukoffa

{"title":"In-Vitro Effect of Ammodaucus Leucotrichus Flower and Fruit Essential Oils on Nitric Oxide Production and Arginase Activity in Human Peripheral Blood Mononuclear Cells (PBMC) from Patients with Behçet Disease","authors":"Djamel Messaoudene, Nourelhouda Ghozali, Hayet Neghliz, Tarek Benabdelkader, Houda Belguendouz, Malika Terahi, Fifi Otmani, Chafia Touil-Boukoffa","doi":"10.1007/s11094-024-03104-2","DOIUrl":"https://doi.org/10.1007/s11094-024-03104-2","url":null,"abstract":"Ammodaucus leucotrichus is an Algerian aromatic medicinal plant, widely known as “Oum-draiga or Kamoune-l’ibel”. In folk medicine, the flower and fruit of this plant are widely used for the treatment of cough, fever, diarrhea, colic, and cold. In this study, we describe for the first time the modulatory effects of flower and fruit essential oils (EOs) of A. leucotrichus subsp. leucotrichus on NOS and Arginase activities and their regulation during Behçet disease, an auto-inflammatory vasculitis of unknown etiology. The EOs were obtained by Clevenger-hydrodistillation and their chemical composition was analyzed by gas chromatography-mass spectrometry (GC-MS). The peripheral blood mononuclear cells of 20 patients and 15 control samples (PBMC) were cultured in RPMI-1640 and incubated with or without seeds and the flowers’ essential oil from A. leucotrichus was dissolved in DMSO (0.01%). Culture supernatants were harvested after 24 h of incubation. NO and urea measurements were, respectively, performed by modified Griess and Berthelot methods. Our results show that essential oils for both fruits and flowers significantly reduce the production of NO production in a concentration-dependent manner. In contrast, significantly increased urea was noted in treated PBMC of BD patients. Our study suggests that EOs extracted from the flower and fruit of A. leucotrichus could have potential immuno-modulatory effects characterized by a down-regulation and up-regulation of NO and urea, respectively, probably by NOS/Arginase balance regulation.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"153 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization and Biological Evaluation of Novel Benzimidazole Derivatives against Candida albicans 新型苯并咪唑衍生物对白色念珠菌的合成、表征和生物学评价

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03099-w

Monika Chauhan, Shivani Gupta, Sarvesh Paliwal, Sumitra Nain

引用次数: 0

Development of a Quantitative Determination Method for Polysorbate 80 in Biologicals by Size-Exclusion High-Performance Liquid Chromatography 利用尺寸排阻高效液相色谱法开发生物制品中聚山梨醇酯 80 的定量检测方法

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03110-4

O. B. Rounova, M. G. Korotkov, O. B. Ustinnikova

引用次数: 0

Synthesis of 5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3H)-thione] and Study of Its Anti-Inflammatory Activity 5,5′-(二硫二基)双[3-苯基-1,3,4-噻二唑-2(3H)-硫酮]的合成及其抗炎活性研究

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-16 DOI: 10.1007/s11094-024-03094-1

G. S. Shakirzyanova, L. Yu. Izotova, O. Kh. Kholbekov, F. Yu. Zhaloliddinov, G. G. Rakhmonova, B. N. Babaev

引用次数: 0

Acetaminophen and Thiosalicylic Acid Sensor Based on Carbon Paste Electrode Modified with Multi-Walled Carbon Nanotubes and Natural Deep Eutectic Solvent 基于多壁碳纳米管和天然深共晶溶剂修饰的碳浆电极的对乙酰氨基酚和硫代水杨酸传感器

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-16 DOI: 10.1007/s11094-024-03090-5

Ebrahim Zarei, Maryam Vafadar, Alireza Asghari

引用次数: 0